Differential Gene Expression between Han Chinese and Japanese

13
Differential Gene Expression between Han Chinese and Japanese Yuan Yuan Prof. Shuhua Xu’s group Population genomic group PICB

TAGS:

description

Differential Gene Expression between Han Chinese and Japanese. Yuan Yuan Prof . Shuhua Xu’s group Population genomic group PICB. Chinese and Japanese are very similar in phenotype. Expression variation among Chinese and Japanese individuals. - PowerPoint PPT Presentation

Transcript of Differential Gene Expression between Han Chinese and Japanese

Page 1: Differential Gene Expression between Han Chinese and Japanese

Differential Gene Expression between Han Chinese and Japanese

Yuan YuanProf. Shuhua Xu’s group

Population genomic groupPICB

Page 2: Differential Gene Expression between Han Chinese and Japanese

Chinese and Japanese are very similar in phenotype.

Page 3: Differential Gene Expression between Han Chinese and Japanese

Expression variation among Chinese and Japanese individuals

Differentlyexpressed

Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached.

Page 4: Differential Gene Expression between Han Chinese and Japanese
Page 5: Differential Gene Expression between Han Chinese and Japanese
Page 6: Differential Gene Expression between Han Chinese and Japanese

Genome locations of 768 DE genes

Page 7: Differential Gene Expression between Han Chinese and Japanese

Functional enrichment of 768 DE genes

Page 8: Differential Gene Expression between Han Chinese and Japanese

Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference

Population

Cis: # genes(snps)

Trans: # genes(snps)

CHB 39 (306) 271 (4544)

JPT 68 (648) 92 (1216)

Page 9: Differential Gene Expression between Han Chinese and Japanese

Distribution of cis-associations(SNPs) relative to the transcription start site (TSS)

Page 10: Differential Gene Expression between Han Chinese and Japanese

Genetic contributions to total expression variation for 11 cis-genes

Page 11: Differential Gene Expression between Han Chinese and Japanese

Cis-gene vs GWAS trait

Page 12: Differential Gene Expression between Han Chinese and Japanese

CTSS vs cis-SNPs

Page 13: Differential Gene Expression between Han Chinese and Japanese

Acknowledgment

Dr. Shuhua Xu

Yang ling, Lu dongsheng, Shi meng, Lou haiyi

Jin wenfei, Pankaj

All in population genomics group


Japanese Language Courses - Amazon S3s3.amazonaws.com/zanran_storage/€¦ · Japanese Language Courses Conversation Business Japanese Japanese Language Proficiency Test ... Japanese

Japanese Language Courses - Amazon S3s3.amazonaws.com/zanran_storage/€¦ · Japanese Language Courses Conversation Business Japanese Japanese Language Proficiency Test ... Japanese

jafia.kyushu-u.ac.jpjafia.kyushu-u.ac.jp/japanese/jfia/contents/14_2/JFIA1997V0014P... · differential-pulse voltammetry ... spectrometry-determination of cadmium and lead in sea

jafia.kyushu-u.ac.jpjafia.kyushu-u.ac.jp/japanese/jfia/contents/14_2/JFIA1997V0014P... · differential-pulse voltammetry ... spectrometry-determination of cadmium and lead in sea

Han-Modular Contents Page - HARTING USA Page Description of the Han-Modular ... Han® D-Sub module . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Han-Modular Contents Page - HARTING USA Page Description of the Han-Modular ... Han® D-Sub module . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Differential Use of Reactive Tokens in Japanese In Turn ... · linguistic features, such as hedges in Japanese, differences are not clearly observed. These and other issues make gender-based

Differential Use of Reactive Tokens in Japanese In Turn ... · linguistic features, such as hedges in Japanese, differences are not clearly observed. These and other issues make gender-based

The Han Institutions and the Great Early Han Expansion

The Han Institutions and the Great Early Han Expansion

The Japanese CinderellaTThe Japanese Cinderellahe Japanese ...

The Japanese CinderellaTThe Japanese Cinderellahe Japanese ...

Caffeine & Nicotine Diani AmaranathShareen Han Diani Amaranath & Shareen Han.

Caffeine & Nicotine Diani AmaranathShareen Han Diani Amaranath & Shareen Han.

Encyclopedia of Japanese History version 0.3 · 2005-08-27 · ishikawa takuboku jo 1222 jo 1652 jomon kaishinto kasugayama-han kawabata yasunari kobu gattai kodoha kokuryukai kotoku

Encyclopedia of Japanese History version 0.3 · 2005-08-27 · ishikawa takuboku jo 1222 jo 1652 jomon kaishinto kasugayama-han kawabata yasunari kobu gattai kodoha kokuryukai kotoku

Essence of Japanese Culture and the Foundation of Business J.D. Han.

Essence of Japanese Culture and the Foundation of Business J.D. Han.

Myae Han - hdfs.udel.edu€¦ · Web viewMyae Han - hdfs.udel.edu

Myae Han - hdfs.udel.edu€¦ · Web viewMyae Han - hdfs.udel.edu

A Basic Course in Partial Differential Equations · 2019-02-12 · This is a textbook for an introductory graduate course on partial differential equations. Han focuses on linear

A Basic Course in Partial Differential Equations · 2019-02-12 · This is a textbook for an introductory graduate course on partial differential equations. Han focuses on linear

Han Pagtuha han Ginoo han Ngatanan

Han Pagtuha han Ginoo han Ngatanan

Differential replication efficiencies between Japanese ...agritrop.cirad.fr/590159/1/journal.pntd.0007046.pdfAuthor summary Japanese encephalitis virus (JEV) causes encephalitis in

Differential replication efficiencies between Japanese ...agritrop.cirad.fr/590159/1/journal.pntd.0007046.pdfAuthor summary Japanese encephalitis virus (JEV) causes encephalitis in

Haring Industrial Connectors Han - Han K 3/0, K 3/2, …...Han HC Modular 14. 02 Han® K 3/0, Han® K 3/2 Features • Only to be used with Han® 24 HPR special hoods and housings

Haring Industrial Connectors Han - Han K 3/0, K 3/2, …...Han HC Modular 14. 02 Han® K 3/0, Han® K 3/2 Features • Only to be used with Han® 24 HPR special hoods and housings

Genomic insights into the relationship between Neolithic ... · between Neolithic Japanese hunter-gatherer, Jomon, and modern East Eurasians ... Ainu Ryukyuan Mainland Japanese Han

Genomic insights into the relationship between Neolithic ... · between Neolithic Japanese hunter-gatherer, Jomon, and modern East Eurasians ... Ainu Ryukyuan Mainland Japanese Han

Han-Brid Contents Page - Steven Engineeringstevenengineering.com/Tech_Support/PDFs/13INDCON_HAN-BRID.pdf · Han- Brid 19. 02 Han-Brid® Features Features General Description The Han-Brid®

Han-Brid Contents Page - Steven Engineeringstevenengineering.com/Tech_Support/PDFs/13INDCON_HAN-BRID.pdf · Han- Brid 19. 02 Han-Brid® Features Features General Description The Han-Brid®

A Basic Course in Partial Differential Equations · A Basic Course in Partial Differential Equations Qing Han American Mathematical Society Providence, Rhode Island Graduate Studies

A Basic Course in Partial Differential Equations · A Basic Course in Partial Differential Equations Qing Han American Mathematical Society Providence, Rhode Island Graduate Studies

Han-Modular Contents Page - Mouser Electronics · 2013-03-21 · Han Modular Han-Modular® Contents Page ... Series Han DD® Quick Lock module Han® DDD module Han® High Density

Han-Modular Contents Page - Mouser Electronics · 2013-03-21 · Han Modular Han-Modular® Contents Page ... Series Han DD® Quick Lock module Han® DDD module Han® High Density

Differential Privacy in Control and Network Systemscarmenere.ucsd.edu/jorge/publications/data/2016_CoDuHaLeMiPa-cdc.pdfJorge Cort´es Geir E. Dullerud Shuo Han Jerome Le Ny Sayan Mitra

Differential Privacy in Control and Network Systemscarmenere.ucsd.edu/jorge/publications/data/2016_CoDuHaLeMiPa-cdc.pdfJorge Cort´es Geir E. Dullerud Shuo Han Jerome Le Ny Sayan Mitra

The 22nd Annual Meeting of Japanese Society for Alternatives to Animal Experiments - asas · 2019. 6. 16. · Soon Young Han 1,2 1KoCVAM Director, 2Toxicological Evaluation and Research

The 22nd Annual Meeting of Japanese Society for Alternatives to Animal Experiments - asas · 2019. 6. 16. · Soon Young Han 1,2 1KoCVAM Director, 2Toxicological Evaluation and Research