Diagnosis and Treatment of Diseases and Disorders · PDF fileDiagnosis and Treatment of...
Transcript of Diagnosis and Treatment of Diseases and Disorders · PDF fileDiagnosis and Treatment of...
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Diagnosis and Treatment of Diseases and Disorders
CausingDesquamative Gingivitis
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Terry D. Rees DDS, MSD
•• Professor, Department Professor, Department of Periodonticsof Periodontics
•• Director, Stomatology Director, Stomatology CenterCenterBaylor College of Baylor College of DentistryDentistryTexas A&M Health Texas A&M Health Science CenterScience CenterDallas, TexasDallas, Texas
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Desquamative Gingivitis
• A clinical manifestation of several diseases and disorders featuring gingival erythema, sloughing ofgingival epithelial tissues and potentially painful erosive gingival lesions.
• Mostly caused by mucocutaneous diseases with the most common being lichen planus, mucous membrane pemphigoid and pemphigus vulgaris. Other causes include hypersensitivity reactions to various oral hygiene products and dental materials.
• Confirmed diagnosis may require histopathological examination and direct immunofluorescence testing.
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Phases of TherapyPhases of Therapy
Diagnostic phaseDiagnostic phaseControl phaseControl phaseConsolidation phaseConsolidation phaseMaintenance phaseMaintenance phase
Modified from:Modified from:Brystryn, 1988Brystryn, 1988Sciubba, 1996Sciubba, 1996
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Accuracy of Dentists in Clinical diagnosis of Oral lesions
Kondon I, Mottlin RW, Laskin DM Quintessence Int 2011;42:575-577
• 976 oral biopses reviewed
• 43% were incorrect• Malignant lesions
clinicallymisdiagnosed 5.6%
Incorrect
• General dentists 46%• Oral Surgeons 42.8%• Endodontists 42.2%• Periodontists 41.2%
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Diagnostic PhaseDiagnostic Phase
•• Past historyPast history
•• Clinical appearanceClinical appearance
•• BiopsyBiopsy–– HistologyHistology
–– Direct immunofluorescenceDirect immunofluorescence
•• Indirect immunofluorescenceIndirect immunofluorescence
•• Culture/smearCulture/smear
•• Ancillary tools?Ancillary tools?
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Biopsy Site SelectionBiopsy Site Selection
•• Choose an area of intact epitheliumChoose an area of intact epithelium
•• Include perilesional tissueInclude perilesional tissue
•• Select normal appearing tissue for some Select normal appearing tissue for some immunofluorescence testingimmunofluorescence testing
•• When possible avoid gingival biopsiesWhen possible avoid gingival biopsies
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PostPost--Surgical ManagementSurgical Management
•• MonselMonsel’’s Solution (ferric subsulfate)s Solution (ferric subsulfate)
•• Synthetic collagenSynthetic collagen
•• GelfoamGelfoam
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ShipmentShipment
Formaldehyde for histopathologic evaluationFormaldehyde for histopathologic evaluation
Ambient temperature transport media Ambient temperature transport media (Michelle(Michelle’’s solution) for DIF s solution) for DIF
Obtain each from pathology lab or Obtain each from pathology lab or immunology lab, usually without chargeimmunology lab, usually without charge
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Control PhaseControl Phase
•• Intense therapy to suppress disease in Intense therapy to suppress disease in days or weeksdays or weeks
•• Efficacy versus safety versus patient Efficacy versus safety versus patient acceptanceacceptance
•• Avoid patient disenchantment over Avoid patient disenchantment over multiple daily treatment yet minimal multiple daily treatment yet minimal results.results.
•• Prevent side effects such as candidiasis.Prevent side effects such as candidiasis.
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Control Phase AlternativesControl Phase Alternatives
•• AggressiveAggressive therapy with very high therapy with very high potency topical or systemic corticosteroidspotency topical or systemic corticosteroids
•• ModerateModerate therapy with high potency therapy with high potency topical corticosteroids combined with topical corticosteroids combined with intralesional injections when indicatedintralesional injections when indicated
•• MildMild therapy with medium or low potency therapy with medium or low potency topical corticosteroids and carrier (Kenalog topical corticosteroids and carrier (Kenalog in Orabase, denture adhesive, patches in Orabase, denture adhesive, patches etc.)etc.)
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Consolidation Phase
• Maintain required type and dose of medications until bulk of lesions have healed
• Weeks not months• If lesions are slow to heal intensity of
therapy may be inadequate
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Therapeutic Endpoints (Perio Workshop 1996)
RemissionSuppression of symptoms
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Maintenance Phase
• Gradually taper frequency of medication use and/or potency of medication
• Goal is to achieve complete remission or to determine lowest dosage necessary to prevent new lesions
• Sustain periodontal health with frequent recall intervals, oral antimicrobials, etc.
• Determine apropriate recall intervals
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Department of PeriodonticsStomatology Center
Baylor College of DentistrySeptember 1, 2011
Number of Patients: 7385
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Disease Frequency7856 Patients (BCD) (September 2012)
• Erosive lichen planus/ lichenoid drug reaction (1015) 12.9%• Xerostomia (839) 10.7%• Chronic candidiasis (767) 9.0%.
Aphthae & other ulcerations (521) 6.6%• Sjögren’s syndrome (447) 5.7%• Allergic reactions (325) 4.1%• Burning mouth syndrome (313) 4.0%• Mucous membrane pemphigoid (213) 2.7%• Hyperkeratosis (176) 2.2%• Migratory glossitis (143) 1.8%• Oral malignancies (74) 0.9%• Pemphigus vulgaris (58) 0.7%_______________________________________________________________________
__________TOTAL (4891) 62.2%
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Other Disorders Causing Desquamative Gingivitis
(BCD) (September 2012)
• Graft vs. host disease 33• Lupus erythematosus 16• Erythema multiforme 14• Leukemic/lymphocytic gingivitis 9
9• Scleroderma 9• Psoriasis 8• Chronic ulcerative stomatitis 8• Sarcoidosis 8
• Lichen planus/Pemphigoides 7 • Gingival histiocytosis X 4• Epidermolysis bullosa 4• Wegener's granulomatosis 3• Pyostomatitis vegetans 3• Actinomycosis 2• Gingival histoplasmosis 2• Ehlers-Danlos syndrome 2
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Mucocutaneous DiseasesMucocutaneous Diseases
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Oral Lichen Planus Types
• Papular• Reticular• Plaque-like• Atrophic
• Ulcerative• Bullous
Andreasen 1968
Reticulated
Erythematous
ErosiveEisen 1993
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ELP Concomitant Findings (BCD)(04/05)
• Skin 12.2%• Genitalia 1.6%
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Vulvo-Vaginal Gingival Lichen Planus Syndrome
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EROSIVE LICHEN PLANUSLABORATORY CONFIRMATION
(September 2012)
Biopsy 72.6%Direct IF 69.5%
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Treatment
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OLP Treatment Options
• Topical corticosteroids• Oral retinoids• Phototherapy• Prednisone• Oral cyclosporin 2.5-5
mg.kg/d in 2 divided doses• Mycophenolate mofetil 0.5-
1.0 g 2x daily• Azathioprine 1-2.4 mg/kg/d
in 1-2 divided doses• Methotrexate 2.5-7.5 mg
once weekly• Griseofulvin microsize 500
mg/d for 2-4 weeks
• Metronidazole 500 mg 2/d for 2 months
• Sulfasalazine 1.5 g/d increase by 0.5 g/d every week for 4-16 weeks. Maximum 4 g/d
• Alefacept• Tetracycline• Aloe vera gel or benzydamine
rinse• Topical calcineurin inhibitors
– Tacrolimus topical (0.03% or 0.1%) 2x daily
– Pimecrolimus topical 15 2x daily
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High Potency Topical Corticosteroids
• 0.25% Desoximetasone (Topicort)• 0.20% Fluocinolone (Synalar HP)• 0.05% Fluocinonide (Lidex)• 0.50% Triamcinolone Acetonide
(Aristocort, Kenalog)Monitor quantity used and do not exceed
15 grams within two weeks
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Highest Potency Topical Corticosteroids
• Betamethasone dipropionate (Diprolene) 0.05% gel, cream, ointment
• Clobetasol (Temovate) 0.05% gel,cream, ointment
• Halobetasol (Ultravate) 0.05% cream, ointment
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Immune Suppression
• Oral application of fluocinonide resulted in no detectable systemic uptake. (Plemons et al 1990)
• Application of large quantity of topical clobetasol to skin resulted in significant systemic uptake. Effect was dose related. (Allen, 2002)
• Oral use of topical clobetasol 1.5 gm daily for 2 weeks resulted in a small but detectable systemic uptake .(IADR abs.- Ezzo and Plemons, 1993)
• To date no adverse systemic efects have been reported related to oral use of topical corticosteroids
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Intralesional Corticosteroids
• Deliver high concentration to diseased site with minimal systemic absorption
• Use alone or in combination with other therapy• Triamcinolone acetonide injectable (Kenalog
10mg/ml or 40 mg/ml)• Tuberculin syringe (27 gauge)• Inject 1mg/cm2
• Repeat at 1-2 week intervals if needed up to 4 times
• Primarily use- buccal, labial mucosa, or tongue
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Potential Adverse Effects
• Xerostomia• Candidiasis• Epithelial atrophy• Systemic effects
– Adrenal suppression– Hypertension– Blurred vision– Elevated blood glucose– GI hemorrhage
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Steroid Carrier Trays
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Disadvantages to Carrier Trays
• Insertion and removal may initiate gingival desquamation
• Risk of increased systemic uptake• Risk of gingival epithelial thinning
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Other Treatments
• Topical tacrolimus (Protopic)- FDA warning• Topical pimecrolimus (Elidel)- FDA warning• Plaque control• Topical cyclosporine A- expense • Soft “plumper” mouthguards- prevent cheek, lip
and tongue irritation• Replace faulty restorations or restorations
causing a contact lichenoid reaction• Doxyclycline monohydrate 100 mg daily for 3
weeks (Ronbeck, 1990)
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Potential New Treatment
• Tacrolimus capsule 1mg dissolved in 1000 ml sterile water– Rinse with 1 tsp 4 times daily– One report describes 20% complete
remission, 70% improvement» Valeric et al Arch Dermatol 2002» Gould A. Am Acad Oral Max-Fac Path 2012 (Oral
presentation)
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Alternative Systemic Therapy
• Cyclosporine• Dapsone• Azathioprine• Tetracycline• Retinoids (Temarotene)• Griseofulvin• Psoralen and ultraviolet light• Others
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Periodontal Status in Patients with Chronic Gingival Erosive
Lichen PlanusAristidis Pontikas
Master of Science ThesisMay 2003
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Relationship between chronicgingival ELP and periodontal
health1 study documented that effective plaque control improves OLP lesions.
Holmstrup et al 1990
1 study found that presence of OLP had no significant effect on periodontal health
Ramon-Fluixa et al 1999
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Materials and Methods
• Periodontal indices were measured in 40 individuals with biopsy confirmed gingival erosive lichen planus
• 40 patients without lichen planus served as age and sex matched controls
• Measurements included Gingival Index, probing pocket depth, clinical attachment level, recession, bleeding on probing, Plaque Index, presence or absence of periodontitis (Machtei et al)
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Results
• Individuals with gingival erosive lichen planus were found to have statistically significant increases in;– Plaque retention– Bleeding on probing– Gingival inflammation
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Results (Cont.)
– Grade I furcation defects– Clinical attachment loss– Gingival recession– Periodontitis(2 or more sites with CAL >6mm and 1 or more
sites with probing depth >5mm)
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Possible Etiology
• Inadequate oral hygiene and plaque induced inflammation
• Effects of drugs causing immune suppression
• Thinning of gingiva associated with use of topical corticosteroids
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Conclusions
• Consider lichenoid drug or contact reactions• Treatment should be progressive:
– High potency steroids– Very high potency steroids– Intralesional steroids (less effective on gingiva)– Carrier trays for gingival OLP– Short term systemic corticosteroids (2 to 3 weeks)– Referral or long term systemic corticosteroids?
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Conclusions (Cont.)
• Periodontal disease is more frequent and severe in patients with gingival erosive LP
• Ideally gingival LP lesions should be controlled before definitive periodontal Rx
• Patients with gingival lesions can tolerate periodontal RX-lesions will worsen temporarily then improve
• Consider use of low dose doxycycline or local delivery antimicrobial agents
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International Oral Lichen Planus Support Group
• Oral lichen planus support group-TAMHSC
• Iolp dallas• www.tambcd.edu/lichen/
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Mucous Membrane Mucous Membrane PemphigoidPemphigoid
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� Dr. Terry Rees
Mucous Membrane Mucous Membrane Pemphigoid (MMP)Pemphigoid (MMP)
� Autoimmune disorder� Oral &/or other mucous
membranes affected� Mean age of onset = 50� Females > Males
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� Dr. Terry Rees
MMPMMPClinical Sites Clinical Sites (09/2011)(09/2011)
Gingiva 93.0%Mucosa 19.8%Palate 10.6%Tongue 3.1%Pharynx 1.1%
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MMP Clinical Sites (September 13, 2012)
Gingiva 89.5%Mucosa 24.4% Palate 10.5%Tongue 7.2%Pharynx 1.1%
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� Dr. Terry Rees
MMPMMPDiagnosisDiagnosis
� Clinical appearance� Histopathological examination� Immunofluorescence
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MMP Laboratory Confirmation
�155 patients• DIF 90.6%• Histopathology 78.7%
�11 patients diagnosed by H&E alone� 5 patients diagnosed by DIF alone
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Treatment
• Steroids similar to oral lichen planus• Plaque control• Low dose doxycycline?• Others
– Dapsone– Methotrexate– Azathioprine– Mycophenolate mofetil (CellCept)– Cyclophosphamide
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Periodontal Status in Patients with Gingival MMP
• Markedly significant increase in plaque and gingival indices.
• Significant increases in class 1 molar furcation involvement and gingival recession
• Periodontal index not significantlyincreased
Tricamo, Melissa et al J. Periodontol 2006:77:398.
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Periodontal status in patients with mucous membrane pemphigoid:
a 5 year follow-up(Schellinck, AE et al 2009)
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• 10 of the same MMP and age, sex and smoking matched control patients compared 5 years later.
• MMP patients had higher gingival index and lingual gingival recession
• Both groups exhibited significant increases in attachment loss but no difference between groups
• Conclusion: MMP patients appear at no greater risk of increased progression of periodontal disease.
Schellinck AE et al. J Periodontol 2009;80:1765-1773.
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NonNon--surgical periodontal therapysurgical periodontal therapy
•• Removal of plaque and calculus is essential but Removal of plaque and calculus is essential but avoid impingement on biologic width.avoid impingement on biologic width.–– RecommendRecommend serial fullserial full--mouth debridementmouth debridement, allowing , allowing
22--3 weeks between treatment sessions to achieve 3 weeks between treatment sessions to achieve partial resolution of tissue inflammation and exposure partial resolution of tissue inflammation and exposure of subgingival calculus.of subgingival calculus.
–– Hand instrumentsHand instruments may be preferred to insure minimal may be preferred to insure minimal tissue traumatissue trauma
–– Consider use of Consider use of subgingival controlled release subgingival controlled release antimicrobial agentsantimicrobial agents
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� Dr. Terri Rees
MMP (04/05)MMP (04/05)Results of Treatment, 102 Patients Results of Treatment, 102 Patients
Treatment RemissionComplete Partial
Topical steroids only 15 44 Topical+short term systemic 12 10Topical+long term systemic 6 4Topical+Dapsone 3 2Topical+antibiotics 4 2
Total number 41 61percent 40.2 59.8
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Therapy Issues
• It is not known whetherasymptomaticlesions should be treated
• Therapeuticendpoints required to prevent progression have not been established
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Pemphigus Vulgaris
� Dr. Terri Rees
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Pemphigus Vulgaris(BCD) (September 13, 2012)
• Females 69.0% average age 48.1 years• Males 31.0% average age 44.9 years• Combined average age 47.1 years
� Dr. Terry Rees
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Skin Lesions
• Bullae• Erosions• Can lead to fluid loss and electrolyte
imbalance• Septicemia
� Dr. Terri Rees
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Oral Sites
• Mucosa 60.4%• Gingiva 43.4 %• Tongue 35.9%• Palate 26.4%• Lips 26.4%
• Mucosa only 11.3%• Gingiva only 7.6%• Tongue only 5.7%
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Treatment
• Topical corticosteroids- rare (Endo et al J Periodontol 2005;76:154-160)
• Topical carrier trays for gingival lesions (Endo et al J Periodontol 2005, 2007)
• Intralesional steroid injections• Short and long term systemic
corticosteroids
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Alternative Treatment
• Methotrexate• Aziathioprine• Dapsone• Mycofenolate mofetil• IV immune globulin• Retuximab (monoclonal antibody)• Plasmophoresis• Others
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Oral Allergic Reactions
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Types of Allergic Reactions Types of Allergic Reactions (BCD)(9/12)(BCD)(9/12)
•• Lichenoid DrugLichenoid Drug 5959
•• Dental Restorative Materials 51Dental Restorative Materials 51
•• Cinnamon/Toothpaste 50Cinnamon/Toothpaste 50
•• Erythema Multiforme 14Erythema Multiforme 14
•• Foods and others 11Foods and others 11
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Contact Stomatitis versus Contact Dermatitis
• Allergic/irritant stomatitis requires longer period of contact
• Saliva dilutes or removes sensitizers and may exert a buffer or neutralizing effect
• Mucosal vascularity may induce rapid dispersion and absorption
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Contact Hypersensitivity Reactions
327 Patient (September 13, 2012)
• Female 285 (87.2%)• Male 42 (12.8%)
• Average age– Female 48.8 years– Male 46.8 years– Combined 48.4 years
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Signs of Dentifrice Allergy
• Generalized or localized gingivitis• Mucositis/glossitis• Cheilitis• Lip edema• Perioral dermatitis
Lamey, Rees, et al. Br Dent J 1990;168:115
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Investigations
• Mucosal biopsy=8• Patch test=13• Rechallenge=10
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Toothpaste Hypersensitivy
• Sensitivity to tarter control and other toothpaste usually involves the flavoring agents, especially cinnamic aldehyde
• Adverse reactions, although uncommon, should be considered in the differential diagnosis of oral or gingival edema, erythema or ulceration
• Oral biopsy and patch testing are important in confirming such reactions and the etiologic agent involved.
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Dentifrices
IngredientsFlavoring(cinnamic aldehyde)Coloring agentsAbrasivesSoaps or detergentsBase materialsPreservatives
SensitizationCommon
RareRareRareRareCommon
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Flavoring Agents
• Cinnamon oil• Cinnamic aldehyde• Menthol (also in
peppermint)• Mint/spearmint• L-carvone• Anethole
• Essential oils– Eugenol
(eucalyptus oil)– Peppermint– Wintergreen
(methylsalicylate)
– Clove oil
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Cinnamon-Induced Contact Stomatitis (BCD)
• 37 patients (32 female, 5 male)• Age range 20-80 years• Mean age 48.4 years
Endo, Rees, et al. Comp Cont Ed Dent 2006;27:403-410.
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Symptoms/Signs
• Symptoms: Burning/soreness 43%• Signs:
– Erythema 84%– White plaque 24%– Fissured tongue 14%– Ulcerations 8%
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Clinical Sites
• Gingiva 60%• Oral mucosa 40%• Tongue 30%• Lips and perioral 24%
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Diagnostic Methods
• Clinical appearance (11) 30%• Biopsy (18) 49%• Patch test (14) 38%
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Biopsy Findings (18 patients)
• Chronic gingivitis/mucositis (18) 100%• Granulomatous reaction (5) 28%• Psoriasiform inflammation (3) 17%• Lichenoid features (1) 6%
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Patch Test Results (14 patients)
• Positive (11) 79%• Negative (3) 21%• Allergen:
– Cinnamic aldehyde (10) – Cinnamic acid (1)
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Exposure Medium
• Toothpaste (27) 62%• Food products (8) 19%• Chewing gum/mints (8) 19%
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Treatment
• Discontinue exposure and avoid further contact with the allergen.
• Results:– Complete remission: 15 of 16– Partial remission: 1
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The Role of Dental Restorative Materials in the Etiology of Oral
Mucosal Diseases
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Allergy to Dental Metals
Nickel SilverMercury Titanium
(Rare)Gold CopperChromium BeryliumCobaltPalladium/Platinum ( cross reactive
with nickel)
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Nickel Allergy
• Nickel is found in bobby pins, needles, pins, metal lipstick holders, watch backs, earring studs, stainless steel (orthodontic bands and wires), metallic dental restorative material.
• Approximately 6% of Americans are allergic to nickel.
• 10% of women are allergic.
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Titanium Hypersensitivity
• Titanium is readily dispersed into adjacent tissues and serum
• The material is extremely biocompatible but occasional hypersensitivity has been reported
• Effectiveness of patch testing has not been fully validated
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Allergy to Non-Metallic Restorations
Allergic reactions may be more common than previously recognized.
Reactions are most often to residual methyl methacrylate monomer or its degenerative products:FormaldehydeBenzoyl peroxideDebutyl phthalate
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Allergy to Non-Metallic DentalRestorations (cont.)
• Some reactions are due to irritant effect rather than allergy.
• Auto-polymerizing acrylic resins release more residual chemicals and are more likely to precipitate adverse reactions.
• Typical allergic reactions include surface erythema and lichenoid changes.
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Resins, Epoxy and Acrylates
• Found in:– Dental composites– Pit and fissure sealants– Orthodontic adhesives– Glazes– Root canal sealants– Bonding agents– Veneers– Temporary crowns
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The Role of Metallic Dental Restorations in the Etiology of Mucosal
and Periodontal Diseases
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Patients Evaluated
• Lichen planus 178• Burning mouth 125• Allergic stomatitis 54• Hyperkeratosis 37• Restoration related
gingivitis/periodontitis 44Total patients 438
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Diseases Associated with Metals Allergy
• Gingivitis/periodontitis 9• Lichenoid reactions 5• Allergic stomatitis 3• Burning mouth 1
Total 18(4.1%)