Diabetes Products and Services First Draft: 03, 2007.

Diabetes Products and Services

First Draft: 03, 2007

Client Brief

1. Summarize the science and scientific developments in the diabetes area

2. Track patents and emerging technologies for solutions to help pre-diabetics and diabetics

3. Track products and services currently available for diabetics (and pre-diabetics) in the market

4. Provide ongoing monitoring and updates for developments in the area

Dolcera Approach

Data collection and mining

1. Scientific and technological trend data collection2. Product categorization3. Demographic, market and regional trend data



Scientific knowledge mapping

1. Develop thorough understanding of the science of the condition2. Map current scientific and product developments on to the knowledge map



Idea development

1. Test technical feasibility of ideas2. Create implementation strategies3. Develop ideas and make them lab-ready4. Create excitement for new ideas

Idea development


Continuous updates

Trend analysis and new idea generation

1. Correlate technical trends with scientific research results 2. Identify successful compositions 3. Find the white spaces based on scientific data and generate new ideas



Dolcera Approach

The Dolcera team• Collects and categorizes a large amount of data from diverse

sources around the world including scientific publications, patents, market surveys, blogs and images

• Develops a knowledge map of the science and maps current

developments on to the knowledge map

• Analyzes the trends and identifies white spaces and innovation opportunities

• Generates new ideas based on the trends and helps implement new ideas

Data Collection and Mining

Scientific Data Collection

Science and medicine sources• Patent databases worldwide • SCIRUS• Google Scholar• Medline, PubMed, Medscape and

other medical databases• Clinical trial data from FDA and

commercial agencies

Product formulation and chemical structure sources• Product surveys• Dietary research• STN

Product Categorization

Products existing in the market will be categorized by• Prescription medication• Over-the-counter medication• Foods: natural and synthetic• Food additives

For each category, the following information will be collected

• Medication substance or active ingredient• Substance action• Effect of substance on the body• Delivery process (e.g. devices)

Social, Market and Regional Trends

Sociocultural trends• Consumer trend surveys• Dietary trends• Data sources: Google, Flickr and Blogs

Market trends• Market surveys (AC Nielsen etc.)• Data from related markets such as pharmaceutical industry• Branded diet plans

Regional trends• Identify local products, local traits, and local preferences • Traditional products such as herbal medicines• Dietary preferences by geography

Knowledge Map of Science

Knowledge Map Development

Overview• Types of diabetes• Signs, symptoms, risk factors

Biochemistry• Molecular biology• Metabolic pathways analysis• Hormonal influences

Mechanisms of action• Effect of mature on metabolic pathways and on hormones• Predicted effect of experimental compositions• Potential white spaces

Trend Analysis and New Idea Generation

Example of Trends

Mechanism of action of currently available products

• Increase insulin • Increase sensitivity to

insulin • Delay absorption of

glucose • Decrease the amount of

glucose released from the liver

• Slow gastric emptying• Lower glycemic index

Whitespace Analysis Example

Current areas of focus• Medication• Diet regulation

Diet regulation approach• Increase low glycemic substitute for the existing food products

and altering the taste and flavor to adjust for the same• Delay glucose absorption by delaying digestion by adding more

soluble fibers in the diet• Use low Glycemic Index (GI) substitutes• Hypothesize methods to decrease the GI of common food

products

Idea Implementation Strategy

Idea Implementation Strategy

Dolcera team will provide• List of compositions and food products• Provide patents and publications to support new ideas• Develop the “virtual products” that could be marketed• Identify technical and market challenges for the “virtual products”

Continuous Updates

Interesting findings

1. Drinking Coffee Helps Lower the Chance of Getting of Type 2 Diabetes - 12-18-2006

2. Eating a Diet High in Fiber Helps Prevent Gestational Diabetes - 10-31-2006

3. Coffee and Green Tea May Help Prevent Type 2 Diabetes - 05-24-2006

Dolcera Approach









Idea development


Idea development


Continuous updates





Key ingredient of Oreo cookies

• Base cake dough• High fructose corn syrup• Dutch cocoa (processed with alkali)• Pure chocolate liquor• Wheat flour• Niacin• Reduced iron• Thiamin mononitrate [vitamin B1]• Riboflavin [vitamin B2]• Folic acid• Partially hydrogenated soybean oil• Baking soda• Cornstarch• Salt• Soy lecithin (emulsifier)• Vanillin - an artificial flavor

Substitutes for High fructose corn syrup

High fructose corn syrup• Contains 55 percent sucrose, which requires insulin to metabolize.

• It has very high glycemic index

Substitutes Sources Taste Sources

Stevia rebaudiana South American shrub Sweet Source

Amasake Traditional Japanese product Sweet Source

Barley malt Slow-digesting sweetener made from sprouted barley

Rich, roasted taste Source

Brown rice syrup Naturally processed sweetener, made from sprouted brown rice

Sweet and mild, buttery flavor

Source

Date sugar Powder made from dried, ground dates Sweet Source

FruitSource® Grape juice concentrate and rice syrup Sunny, bright taste Source

Maple syrup Boiled sap of sugar maple trees Sweet Source

Sucanat® Branded ingredient made from evaporated sugar cane juice

Rich sweet taste Source

Substitutes for wheat flour

Wheat flour• Powdery substance derived by grinding or mashing the whole wheat grain

• White flour contains diabetes-causing contaminant alloxan Source

Substitutes Application Fiber content Sources

Barley, oats, rye Substantially Lower Type 2 Diabetes

High in soluble fiber Source

Coconut Flour Low-Carb, Gluten-Free Higher fiber content (insoluble and soluble fiber)

Source

Buckwheat Gluten-Free High soluble fiber Source

Amaranth Gluten-Free 3 time higher fiber content Source

Ground flaxseeds High in Omega 3 fatty acids, fibre and manganese.

High soluble fiber content Source

Whole grain flours Low glycemic index – contains wheat bran

Soluble fibers Source

Super Seed™ Improve glucose tolerance Abundant in mucilaginous soluble fiber

Source

Mitigation - High fructose corn syrup

High fructose corn syrupIncreased consumption of high-fructose corn syrup resulting in depletion of chromium in the body, which is important in helping glucose pass from the bloodstream into the cells

Mitigators Application Food type Source

Chromium Helps cells respond properly to naturally produced insulin

Cookies Source

Dilution approach Cost effective and low glycemic index

Bakery products, pastas, rice, snacks, potatoes, sauces, gravies, beverages, soups, casseroles and candies

Source

Condensed 6-O-.alpha.-D-glucopyranosyl-fructofu- ranose (palatinose)

Reduced digestion and low glycemic index

Milk products, baked goods, sandwich spreads, margarine products, cooking oils, instant products, beverages, chocolates, hard caramels, soft caramels, chewing gum, coated tablets, fondant products, jelly products, etc.

Source

Gamma-cyclodextrin Reduce insulin intolerance and postprandial insulin secretion

Snacks, cookies Source

Wheat flourIngredients can be combined with regular wheat four mitigating its adverse effects by lowering glycemic index and slowing digestion

Mitigators Application Food type Source

Crosslinked or inhibited starch with sodium trimetaphosphate (STMP) and/or sodium tripolyphosphate (STPP)

Slowly digestible Crackers, breads, muffins, bagels, biscuits, cookies, pie crusts, and cakes; bars, pizza, pasta, dressings, pie fillings, sauces, gravies; lite syrups; puddings; custards; yogurts; sour creams; beverages, including dairy-based beverages; glazes; condiments, confectioneries and gums; and soups.

Source

Soluble viscous fiber in a solid crisp matrix (guar gum)

Delays stomach emptying, and thus delays or limits glucose absorption

Snack or meal Source

Glucomannan, xanthan gum, and alginate

Low glycemic index, Promoting satiety, promoting weight loss

Food product (dietary supplement or meal replacement)

Source

Xanthan, carragenan, acetan, guar, or xyloglucana

Slow digestion, reducing blood glucose, reducing postprandial blood glucose

Food such as a biscuit Source

Mitigation – Wheat flour

Products substitute for High fructose corn syrup

Company name Product Key ingredient Image Diabetic application

Fenwicks Inc Cookies Splenda sweetener, a sucralose derived from white sugar.

Does not affect the blood sugar levels

Sun-Rype Products Ltd

FruitSource® Grape juice concentrate and rice syrup

Promote heart health and reduce the risk of diabetes and stroke

Wholesome Sweeteners In

Sucanat® Evaporated sugar cane juice

Lower blood pressure, prevent and reverse diabetes

Products substitute for wheat flour

Company name Product Key ingredient ImageDiabetic

application

Fabes Oatmeal Cookies Whole grain barley flour

Substantially Lower Type - 2 Diabetes

Garden of Life Super Seed™ Organic seeds, sprouted grains and legumes, abundant in soluble fiber

Improve glucose tolerance

Dixie Carb Counters

Coconut Macaroonie Cookie Mix

Coconut flour -higher fiber content (insoluble and soluble fiber)

Low-Carb, Gluten-Free

Diabetes Products and Services First Draft: 03, 2007.

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Transcript of Diabetes Products and Services First Draft: 03, 2007.