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Point-of-care medical diagnostics for improved healthcare outcomes

Emtech India 2010 Conference, Bangalore

Dhananjaya Dendukuri, CEO & Co-Founder, Achira Labs Pvt. Ltd.

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Background & Motivation

The problem of inaccessible medical DxHigh costs and infrastructure neededCentralized testingCorrelation of resultsDrug resistant strainsSpread of epidemics

The solution - (POC) testsFaster, simpler, cheaperMultiplexed, sensitive, automated and integrated

Disease Annual Deaths

HIV 2.9 million

TB 1.6 million

Malaria 2 million

Other IDs

> 2 million

Yager et al., Ann. Rev. Biomed. Eng. 2008

Microfluidics – a tool for sample processing and fluid manipulation

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Chip

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Microchannel architecture - fabrication enabled by IC technologies. Reagent storage on chip simplifies testing

Multiplexing – novel IP enabled manufacturing methods for chip loading with multiple reagents (patents filed)

High sensitivity - enabled by newly engineered materials and sensitivity

                                                     

                                        

                                                         

  Test 1  Test 2  Test 3  Test 4

b0.1 mm

Dendukuri et al, Lab Chip (2007)

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Reader

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Characteristics Highly sensitive optical detection

techniques - sub nM sensitivity Optimized internal electronics for

high signal-to-noise ratio measurements

Automated with fluid control algorithms

Future Plans Field testing on protein panels

over the next 12 months Commercial Release 2012

2.2nM

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Acknowledgements

04/12/235

Achira Labs is part of Group Lifespring Investors – Nadathur Chairman, Achira Labs – Suri Venkatachalam Connexios Life Sciences Advisors at MIT – Patrick S. Doyle & T. Alan Hatton Team at Achira Labs

www.achiralabs.com