Development of the Pharyngeal Arches - Temple University · PDF fileDevelopment of the...
Transcript of Development of the Pharyngeal Arches - Temple University · PDF fileDevelopment of the...
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Development of the Pharyngeal Arches
Thomas A. Marino, Ph.D.Temple University School of Medicine
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Competencies: Upon completion of this section of the course, the student must be able to:
1. Recall the embryonic precursors that give rise to the adult structures of the head and neck.
2. Describe how these precursors, especially the pharyngeal arches, form the different structures in the head and neck.
3. Determine how the congenital abnormalities thyroglossal duct cysts, and cervical fistulas would occur.
4. Compare and contrast the development of the different pharyngeal pouches, clefts, arches, mesoderm, nerves, and connective tissues.
5. Use this information to figure out the cause of other congenital defects that you might see clinically.
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Introduction • The origin of tissues that will give rise to head structures.
• Introduce pharyngeal or branchial arches.
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Pharyngeal Arches
• Appear at 4 - 5 weeks. • Play important role in the formation of
the face and neck structures.
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27 days, 29 days, 35 days
1 2
1 2 3
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1st arch
2nd arch
3rd arch
4th arch
1st pouch artery
1st cleft
cartilage
nerve
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1st arch
2nd arch
3rd arch
4th arch
1st pouch artery
1st cleft
cartilage
nerve
• Arches have: • Ectoderm externally • Mesenchymal core • Endoderm internally
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Primitive Pharynx
• Each arch separated by: • a Pharyngeal Cleft
(Groove) on the outside • a Pharyngeal Pouch on
the inside • together they can make
up a Pharyngeal Membrane
• Each arch consists of: • cartilage • aortic arch • cranial nerve • mesenchyme
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Pharyngeal Arches
• Each arch has its own blood supply.
• These are the aortic arches.
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Neural crest cells
• migrate into: • pharyngeal arches - from midbrain, hindbrain • Form pharyngeal arch skeletal structures
• form bones of the face and the skull • form hyoid cartilage (from 2nd arch) • plus cartilage, bone, dentin, tendon, dermis,
meninges, sensory neurons and glandular stroma
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• The early brain has three segments • Forebrain • Midbrain • Hindbrain
• On either side are somatomeres rather than somites.
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Rhombomeres
midbrain
R8 R7 R6 R5 R4 R3 R2 R1
midbrainforebrain
IV III II IHoxa2
Hoxb2Hoxb1
Hoxb3Hoxb4
Hoxb5Hoxb6
Otx2 Msx Dlx
Barx
• The hindbrain can be further subdivided into rhombomeres
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1. Neural crest cells from different regions of the brain stem migrate into the different pharyngeal arches. (1) rhombomeres.
(1) R1 and R2 to Arch 1 (2) R4 to Arch 2 (3) R6 and R7 to Arch 3 (4) R8 to Arch 4
(2) Midbrain (1) Face
midbrain
R8 R7 R6 R5 R4 R3 R2 R1
midbrain
forebrain
IV III II I
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• Neural crest cells migrate into the head region and the pharyngeal arches.
• Hox genes are not expressed anterior to rhombomere 3.
• Otx2, Msx, Dlx, Barx are expressed during development of cephalic structures
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Neural crest cells and head development
• Epithelial mesenchymal interactions important. • Sonic Hedgehog • Fibroblast growth factor • Bone morphogenetic proteins
• Chemoattraction factors • TBX1 • Twist • Vegf • FGF receptor 1
• Inhibitory factors • Cilia and ciliary proteins are important
• Ciliary dysfunction is present in some syndromes • Kinesin-like protein implicated in the dysfunction of cilia • This affects polarized growth and cell shape • Shortened mandibles end up being present !
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Ectodermal Placodes & Neural Crest
• Ectodermal Placodes & Neural Crest form neurons of: • 5th, 7th, 9th and 10th sensory ganglia • Neurons migrate into each arch. • Each arch has its own nerve supply.
midbrain
R8 R7 R6 R5 R4 R3 R2 R1
midbrain
forebrain
IV III II I
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• Stomadeum is the future oral cavity.
• Bounded posteriorly by the buccopharyngeal membrane (oral plate).
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Pharyngeal Arches• At 5 weeks:
• Stomadeum (S) is present
• Surrounded by the 1st arch.
• Ectoderm surrounds the stomodeum.
• Ectoderm is found anterior to the tonsillar fossa
S1st arch
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2126 day embryo
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Fate of Pharyngeal Clefts
1st arch
2nd arch
3rd arch
4th arch
1st pouch artery
1st cleft
cartilage
nerve
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First Pharyngeal Arch
• First arch develops into 4 prominences: • Two maxillary
prominences • Two mandibular
prominences • First Cleft
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Development of the External Auditory Meatus
■First Pharyngeal Cleft gives rise to the external auditory meatus. ■1st and 2nd arches give rise to external ear
1st arch
2nd arch
3rd arch
4th arch
1st pouch
external auditory meatus
auditory tube
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1st arch
2nd arch
3rd arch
4th arch
1st pouch
external auditory meatus
auditory tube
cervical sinus
• The region between the 2nd arch and the 3rd, 4th and 6th arches is called the cervical sinus.
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Fate of the Ectoderm
• 1st Arch • skin over maxilla, mandible, some around
the ear and external auditory meatus • salivary glands • enamel of teeth • epithelium of buccal cavity • epithelium over anterior body of the tongue
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Ectoderm
• Second Arch • epithelium over part of external auditory
meatus • some epithelium behind the ear
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Ectoderm
• Third Arch • epithelium around the ear
• Fourth Arch • epithelium around the ear
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Fate of Pharyngeal Pouches
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Development of the Pharyngeal Pouches
• First pouch gives rise to: • middle ear cavity • auditory tube
First Arch
Second Arch
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Development of the Tonsils
• Second pouch endoderm and mesoderm gives rise to: • Palatine tonsillar
fossa. • Secondarily lymphatic
tissue is incorporated into the pouch.
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Development of the Thymus
• Endoderm of the third pouch proliferates and gives rise to the thymus during week 4.
• First start as endodermal tubes.
• This tissue envades the mesoderm.
3rd Pouch
Thymus
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Development of the Thymus
• Thymic tissue then loses connection with the pharynx.
• Thymus descends during weeks 4 - 7.
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Thyroid
Thymus
The thymus migrates into the superior mediastinum
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Development of the Thymus• Thymus cortical epithelium is derived from ectoderm. • Thymus medullary epithelium is derived from endoderm. • Lymphoid tissue infiltrates later.
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Development of the Parathyroids
• Inferior parathyroids develop from the third pouch at week 5.
• Detach from pharynx and descend.
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Development of the Parathyroids
• End up at the inferior pole of the dorsum of the thyroid by week 7.
Inferior parathyroids
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Development of the Parathyroids
• Superior parathyroids develop from the fourth pouch at week 5.
• Detach from pharynx and descend.
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Development of the Parathyroids
• End up at the superior pole of the dorsum of the thyroid by week 7.
Superior parathyroids
Inferior parathyroids
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Parathyroid
• Chief cells • Parathyroid hormone:
• Increase Calcium concentration in blood
• Decrease Phosphate concentration in blood
• Oxyphil cells • ??
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Development of the Thyroid• The thyroid develops as a diverticulum from the
foramen cecum. • Foramen cecum is located between the tuberculum
impar and the hypobranchial eminence.
1st arch2nd arch3rd arch4th arch hypobranchial
eminence
epiglottal swelling
tuberculum impar
1st cleft
lingual swelling artery
cartilage
Foramen Cecum
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Development of the Thyroid• The thyroid develops as a diverticulum from
the foramen cecum. • Foramen cecum is located between the
tuberculum impar and the hypobranchial eminence.
1st arch2nd arch3rd arch4th arch hypobranchial
eminence
epiglottal swelling
tuberculum impar
1st cleft
lingual swelling artery
cartilage
Foramen Cecum
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Development of the Thyroid• The thyroid develops as a diverticulum from the
foramen cecum. • Foramen cecum is located between the tuberculum
impar and the hypobranchial eminence.
1st arch2nd arch3rd arch4th arch hypobranchial
eminence
epiglottal swelling
tuberculum impar
1st cleft
lingual swelling artery
cartilage
Foramen Cecum
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Development of the Thyroid
• The thyroid descends in front of the pharynx.
Thryoglossal Duct
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Development of the Thyroid
• The thyroid gland remains in contact with the pharynx for a period of time by a narrow duct called the thyroglossal duct.
Thryoglossal Duct
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Development of the Thyroid
• The thyroid gland descends to the region of the junction of the trachea and the larynx.
Thryoglossal Duct
Tongue
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Development of the Thyroid
• Path of migration of the thyroid.
• From base of tongue
• In front of hyoid • In front of
thyroid cartilage
Thyroid gland
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Development of the parafollicular cells of the thyroid
• Parafollicular cells of the thyroid are the C cells that produce calcitonin.
• They develop from the 4th (5th) Pouch (Ultimobranchial body)
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• Thyroid • Follicles filled with thyroglobulin • Follicle secretes:
• Thyroxine (T4) and Triiodothyronine (T3) • Parafollicular cells of thyroid
• Calcitonin – protection against excess bone resorption
Follicle
FollicleFollicle
Parafollicular cells
Follicular cells