Design, Syntheses, and Antitumor Activity of Novel Chromone and Aurone Derivatives.
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2007 Benzopyran derivatives R 0350 Design, Syntheses, and Antitumor Activity of Novel Chromone and Aurone Deriv- atives. — Aurone analogues bearing a cyclic tertiary amine moiety such as (III) (6 examples) and chromone analogues bearing a heteroaryl thioether moiety such as (V) (7 examples) are prepared in higher yields and shorter reaction times under micro- wave irradiation than by conventional heating. The products are tested for their antitu- mor activity against 4 kinds of human solid tumor cell lines. The most active candidates are found among (III). — (HUANG, W.; LIU, M.-Z.; LI, Y.; TAN, Y.; YANG*, G.-F.; Bioorg. Med. Chem. 15 (2007) 15, 5191-5197; Key Lab. Pestic. Chem. Biol., Coll. Chem., Cent. China Norm. Univ., Wuhan 430079, Peop. Rep. China; Eng.) — Klein 44- 131
Transcript of Design, Syntheses, and Antitumor Activity of Novel Chromone and Aurone Derivatives.
2007
Benzopyran derivativesR 0350 Design, Syntheses, and Antitumor Activity of Novel Chromone and Aurone Deriv-
atives. — Aurone analogues bearing a cyclic tertiary amine moiety such as (III) (6 examples) and chromone analogues bearing a heteroaryl thioether moiety such as (V) (7 examples) are prepared in higher yields and shorter reaction times under micro-wave irradiation than by conventional heating. The products are tested for their antitu-mor activity against 4 kinds of human solid tumor cell lines. The most active candidates are found among (III). — (HUANG, W.; LIU, M.-Z.; LI, Y.; TAN, Y.; YANG*, G.-F.; Bioorg. Med. Chem. 15 (2007) 15, 5191-5197; Key Lab. Pestic. Chem. Biol., Coll. Chem., Cent. China Norm. Univ., Wuhan 430079, Peop. Rep. China; Eng.) — Klein
44- 131
