Descriptive Epidemiology of Childhood Leukaemia...Leukaemia is a malignancy of the bone marrow. It...
Transcript of Descriptive Epidemiology of Childhood Leukaemia...Leukaemia is a malignancy of the bone marrow. It...
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Descriptive Epidemiology of
Childhood Leukaemia
C.MagnaniCPO Piemonte and University of Eastern
Piedmont
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Leukaemia is a
malignancy of the bone
marrow.
It affects the cells that
produce white blood
cells.
The main types of
childhood leukaemia
are acute lymphoblastic
(ALL) and acute non
lymphoblastic (ANLL).
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ALL are classified according to immunophenotype:
T-cell 9.5%
B-cell 4.1%
preB / common 86.2%.
ANLL are classified according to the FAB classification.
M1-M2 acute myeloid 32.1%
M3 promyelocitic 35.7%
M4 myelomonocitic 17.9%
M5 monocitic 7.1%
Other 7.2%
Childhood Cancer Registry of Piedmont, 1998-2002:
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ICCC
I Leukemia (a) Lymphoid Leukemia - Acute lymphocytic leukemia (ALL)
- Lymphoid excluding ALL
(b) Acute non-lymphocytic leukemia
(c) Chronic myeloid leukemia
(d) Other specified leukemia
(e) Unspecified leukemia
Current classification in epidemiology is the
ICCC-2
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ICCC-3, based on ICD-O-3
I Leukemias, myeloproliferative diseases, and myelodysplastic dise
(a) Lymphoid leukemias
(a.1) Precursor cell leukemias
(a.2) Mature B-cell leukemias
(a.3) Mature T-cell and NK cell leukemias
(a.4) Lymphoid leukemia, NOS
(b) Acute myeloid leukemias
(c) Chronic myeloproliferative diseases
(d) Myelodysplastic syndrome and other myeloproliferative disease
(e) Unspecified and other specified leukemias
II Lymphomas and reticuloendothelial neoplasms
(a) Hodgkin lymphomas
(b) Non-Hodgkin lymphomas (except Burkitt lymphoma)
(b.1) Precursor cell lymphomas
(b.2) Mature B-cell lymphomas (except Burkitt lymphoma)
(b.3) Mature T-cell and NK-cell lymphomas
(b.4) Non-Hodgkin lymphomas, NOS
(c) Burkitt lymphoma
(d) Miscellaneous lymphoreticular neoplasms
(e) Unspecified lymphomas
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Accis, EJC 2006
Leukemia, age 0-14
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Accis, EJC 2006
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Leukemia incidence in Europe
Accis 1988-1997
0
5
10
15
20
25
30
35
40
45
Europe British I. East North South West
A.S
.In
cid
en
ce
(x
mil
lio
n)
ALL
ANLL
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Time trends in incidence
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Incidence by age and gender
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Figure 2. Acute Lymphoblastic Leukaemia. Incidence rates by year of age and period
0,0
20,0
40,0
60,0
80,0
100,0
120,0
140,0
160,0
180,0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Age at diagnosis (years)
Incid
en
ce R
ate
(p
er
millio
n)
75-79
80-84
85-89
90-94
95-98
CCR Piedmont
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ALL incidence in Europe, 1970-1999. ACCIS database
E. Steliarova_Foucher et al. Lancet 2004
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Eur J Cancer, 2006; 42:78-83.
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Leukaemia 0-14
0
1
2
3
4
5
1970 1975 1980 1985 1990 1995 2000
year of death
std
. ra
tes (
eu
r.p
op
.) x
100,0
00
Males
Females
Mortality for leukaemia age 0-14, Italy
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Survival for ALL age 0-14, Italy
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Survival for ANLL age 0-14, Italy
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