Dermatology 911
Transcript of Dermatology 911
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Dermatology 911Life threatening rashes and what to do
Steven T. Chen, MD MPH MS-HPEdAssistant Professor, Harvard Medical School
Attending in Dermatology and Internal Medicine
@DrStevenTChen
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Disclosures
Served on Pfizer advisory board for digital media.
Many of the treatments/medications discussed today are in the setting of off-label usage.
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Objectives for this session
• Evaluate and properly initiate management a new potentially severe cutaneous eruption in the hospitalized patient.
• Understand the salient clinical features to avoid missing a severe rash, such as SJS/TEN, DRESS, AGEP, purpura fulminans, etc.
• Formulate a framework for when dermatology consultation may be necessary or advised.
• Analyze available patient characteristics and data to identify culprit drugs when faced with an adverse skin reaction to medication.
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What do you think of when you hear dermatology?
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The Merits/Truths of Dermatology
• One of the few organ systems in which you can actually see disease
• Easily tested and biopsied for analysis (for patient care and for research)
• A large immunologic organ• The skin doesn’t lie!
– Start with the physical exam, and then take a pertinent history
• Difficult to generate a differential unless you know what the diagnoses are
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Some Review on Morphology
• Macule – flat, <1 cm
• Patch – flat, >1 cm
• Papule – raised, <1 cm
• Plaque – raised, > 1 cm
• Vesicle – fluid filled, <1 cm
• Bulla – fluid filled, >1 cm
• Pustule – pus filled
• Nodule
• Tumor
• Wheals
“Maculopapular”
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A different approach
• Red Flags– Painful
– Target lesions
– Mucosal involvement
– Systemic involvement
– Certain blisters/bullae
– Erythroderma
– A rash in an immunosuppressed patient
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Case 1
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HD 2
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HD 2 → HD 3
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Nikolsky Sign
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Patient History
• 69M with follicular lymphoma on bendamustine and rituximab who was started on trimethoprim/sulfamethoxasole for PCP prophylaxis.
• Has been on trimethoprim/sulfamethoxasole for 2 weeks. Presented to clinic with subjective fevers, myalgias, and skin eruption as pictured.
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Audience Question
• Your physical exam reveals erythroderma with focal duskiness and skin sloughing with + nikolskyonly on the pictured lower extremity. What is your diagnosis at this exact moment in time?
• A: Stevens Johnson Syndrome
• B: Toxic Epidermal Necrolysis
• C: SJS/TEN overlap syndrome
• D: Bullous Pemphigoid
• E: Linear IgA
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Audience Question
• Your physical exam reveals erythroderma with focal duskiness and skin sloughing with + nikolskyonly on the pictured lower extremity. What is your diagnosis at this exact moment in time?
• A: Stevens Johnson Syndrome
• B: Toxic Epidermal Necrolysis
• C: SJS/TEN overlap syndrome
• D: Bullous Pemphigoid
• E: Linear IgA
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Stevens Johnson Syndrome
• Macular, atypical targetoid lesions with duskiness, mucosal involvement/sloughing, and positive nikolsky with <10% BSA epidermal detachment or pending detachment. Conjunctival injection and hemorrhagic lips are common.
• >30% - Toxic Epidermal Necrolysis
• 10-30% - SJS-TEN overlap syndrome
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Chen ST, Velez NF, Saavedra AP. Adverse Cutaneous Drug Reactions. Ch 145, Principles and Practice of Hospital Medicine, 2nd ed.
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Target versus targetoid
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https://my.clevelandclinic.org/health/diseases/17656-stevens-johnson-syndrome
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18https://app.figure1.com/rd/images/578387610d39995a44b253f7
https://adc.bmj.com/content/98/12/998
https://www.infectiousdiseaseadvisor.com/infectious-diseases/stevens-johnson-syndrometoxic-epidermal-necrolysis/article/610572/
https://cdemcurriculum.files.wordpress.com/2015/09/ten.png
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www.mghcme.orgCourtesy of Dr. Art Saavedra
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Prognostication can be calculated with SCORTEN
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Bastuji-Garin S, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000 Aug;115(2):149-53.
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SJS/TEN
• A new study last year was the first to study an American cohort (all prior studies were in European cohorts) with interesting findings.– Trimethoprim/sulfamethoxasole was the most
common culprit– Overall survival was better than predicted than
SCORTEN– Prognosis worsened drastically with BSA > 40%– No convincing data regarding treatment options
• Overall, the study is largely exploratory and hypothesis generating.
21 Micheletti et al. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter
Retrospective Study of 377 Adult Patients from the United States
Journal of Invest Dermatol. Nov 2018, 138:11, 2315–2321.
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SCORTEN updated → ABCD-10
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ABCD-10
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• Age > 50 1 pt
• Bicarb < 20 mmol/L 1 pt
• Cancer (active) 2 pts
• Dialysis 3 pts
• 10% BSA 1 pt
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After 4 days:
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Progression to TEN
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3 weeks later…
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A word on treatment
• Discontinuation of offending agent (4-21 days prior to rash)
– Antibiotics, Antiepileptics, NSAIDs most common
• Good wound care (consider burn unit)
• Antibiotics only if necessary (sepsis given open skin)
• No debridement
• Consider Ophthalmology, GYN/Urology consult
• Consult Dermatology to guide possible immunosuppressive therapy to halt progression
– Etanercept
– Cyclosporine
– Intravenous Immunoglobulin
– Steroids
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What else is in the differential?
• Stevens Johnson Syndrome/Toxic Epidermal Necrolysis
• Acute Stage IV GVHD
• Pemphigus vulgaris
• Staph Scalded Skin Syndrome
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Stage IV GVHD
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• Clinically very difficult to distinguish
• Patient’s history most helpful (medications and ?BMT)
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Pemphigus Vulgaris
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• Also + Nikolsky
• No targetoid lesions
• No duskiness
(meaning no cell
death)
• Systemically not ill
• More commonly
gingiva involved,
NOT lips
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Staphlococcal Scalded Skin Syndrome
• From bloodborne staph toxin that causes cleavage of Desmoglein, protein that holds skin together.
• Desquamation is more superficial than SJS/TEN.
• Skin is not as painful.• Adult patients should
have renal failure!• Jelly Roll!
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http://www.odermatol.com/odermatology/32013/22.SSSS-OishiT.pdf
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Erythema Multiforme
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Let’s Compare
SJS/TEN EM Pemphigus S IV GVHD SSSS
Morphology Targetoid, dusky, and flat (macule)
Target, and raised (papule)
Less inflammatory, no duskiness
Dusky, macular or papular
Erythema/ superficial sloughing
Nikolsky + - + + +
Skin Pain ++ +/- + ++ +/-
Important history
New drug Recent infection
n/a BMT ?exposure and AKI/CKD
Treatment location
Inpatient management
Usually observation
Outpatient management
ICU Level care Inpatient management
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Call Dermatology!!!
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Case 2
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Look at all those
angular and
stellate edges!
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HPI
• 44M who walked into the ED with flu-like symptoms and headache. Was bitten by his dog the day prior.
• Rash developed suddenly while patient was getting a CT scan.
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Purpura Fulminans
• Microvascular occlusion in skin with platelet-fibrin thrombi
• No inflammation seen on biopsy (purely vascular)
• “DIC in the skin”
• A true emergency!
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Differential Diagnosis
• Purpura Fulminans Differential
– Infection
• Bacterial – Staph, Strep, encapsulated organisms
• Viral (VZV, CMV)
• Tick-borne illness (Rickettsial, babesia)
• Malaria
– Catastrophic antiphospholipid syndrome
– Protein C/S deficiency (in pediatric population)
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History continued
• What other historical questions might you ask the patient or family?– History of splenectomy
• Increased risk of encapsulated organism sepsis– Meningococcus
– Pneumococcus
– Hemophilus Influenza
– Capnocytophaga
» History of dogbites
– Immunization history
– Travel
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Continued hospital course
• Blood Cultures – grew Capnocytophaga canimorsus
• We recommended supportive wound care to minimize shearing of necrosed skin
• Patient continued to have refractory shock to multiple pressors, with need for amputation of all four limbs.
• Family members decided to make patient CMO. Patient passed away ~ 72 hours after onset of symptoms.
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A brief detour on COVID-19
• Many skin manifestations have been reported in COVID-19. Most (such as “covid-toes”) are associated with mild disease.
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Freeman et al. JAAD, May 30 2020.
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A brief detour on COVID-19
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Freeman et al, JAAD June 30, 2020.
• In the inpatient population, the critically ill tend to show sequela of thrombotic
processes.
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Case 3
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HPI
• 72F with recent lap→ open cholecystectomy, with nonhealing ulcers. Ulcers are exquisitely tender.
• What is the most likely diagnosis?
– Before you answer, let’s do a full skin exam and see if there are any other clues….
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On the left shin:
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Did that help?
• What is the most likely diagnosis?
– A – bacterial infection
– B – burn injury
– C – factitial dermatosis
– D – neutrophilic dermatosis
– E – who knows? I need a biopsy to tell!
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Did that help?
• What is the most likely diagnosis?
– A – bacterial infection
– B – burn injury
– C – factitial dermatosis
– D – neutrophilic dermatosis
– E – who knows? I need a biopsy to tell!
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Neutrophilic Dermatoses
• Group of diseases where neutrophils create violaceous ulcers, nodules, plaques, in the skin.
– Pyoderma Gangrenosum
– Sweets Syndrome
– Behcet’s Syndrome
• Pathergy is a hallmark of these diseases
– Need to stop surgery from debriding!!
• There are diagnostic criteria, but usually a diagnosis of exclusion
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Pyoderma gagrenosum
• In this case, our clinical diagnosis was that of pyoderma gagrenosum.
• Classic exam findings.
• Classic history of pathergy worsening the skin eruption.
• Treatment requires immunosuppression.
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How do you mitigate risk of infection
• Often, we will perform a biopsy for both H+E and tissue culture, to rule out infectious processes.
• Co-administration of immunosuppressant and antibiotics is a reasonable option to start, with further adjustment based on clinical course.
• Dosing usually starting at equivalent of prednisone 1mg/kg
• What if the patient requires another surgical procedure?
• What if a patient with a h/o PG requires a surgical procedure?
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Discuss with surgeon, but may need some steroid or CsA.
Expectant management may be reasonable.
Xia et al, JAAD, 2/2018.
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Another example of effect of immunosuppression
• Started on Prednisone 60 mg PO QD
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Take home points
• Beware of the dangerous rashes and red flags
– Painful skin
– Systemic involvement
– Immunosuppressed patient
– Target lesions and positive Nikolsky on exam
• Always feel free to call your dermatology consultant if you need help.
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@DrStevenTChen
Thank you!