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The NIH Guide announces scientific initiatives and provides poliq and administrative infomiation t o indivi duals and organizationswho need to be kept informed ofopponunities. requiremenn. and changes in extra mural p r o p m s administered b!. the National Insrltutes o f Health V o l . 18, NO. 39 November 3, 1989

Vol. 18, No. 39, November 3, 1989

DATED ANNOUNCEMENTS (RFPs AND RFAs)

TRIAL OF CALCIUM SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF W'

PREECLAMPSIA AND PRETERM BIRTH (RFP) ........................................ 1 National Institute of Child Health and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

THE DATA COORDINATING CENTER FOR THE NICHD TRIAL OF CALCIUM SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF PREECLAMPSIA AND PRETERM BIRTH (RFP) ..................................................... 1 National Institute of Child Health and Human DevelopmentIndex: CHILD HEALTH, HUMAN DEVELOPMENT

IN VIVO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV (RFP) . . . . . . . . . . 2 National Institute of Allergy and Infectious DiseasesIndex: ALLERGY, INFECTIOUS DISEASES

IN VITRO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST HIV (RFP) ......... 2 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES

NOTICE - CLAUDE D. PEPPER GERIATRIC RESEARCH AND TRAINING CENTERS (RFA) . . . . . 3 National Institute on AgingIndex: AGING

ONGOING PROGRAM ANNOUNCEMENTS

INVESTIGATIONS INTO METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS USED IN RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS ......................... 3 National Institutes of HealthAlcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTES OF HEALTH

ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION

DATED ANNOUNCEMENTS (RFPs AND RFAs)

TRIAL OF CALCIUM SUPPLEMENTATION IN PREGNANCY FOR THE PREVENTION OF PREECLAMPSIA AND PRETERM BIRTH

R F / 9LAILABL'. . NICHD-PRP-90-06

P.T. 34; K.W. 0715160, 0745027, 0710095, 0715115, 0755015

N a t i o n a l I n s t i t u t e o f Chi ld Heal th and Human Development

The N a t i o n a l I n s t i t u t e o f Chi ld Heal th and Human Development h a s a requirement f o r a c l i n i c a l t r i a l t o determine i f calcium supplementat ion d u r i n g pregnancy h a s a p r e v e n t i v e e f fec t on t h e inc idence o f pregnancy-induced h y p e r t e n s i o n (PIHI and pre te rm b i r t h . T h i s p r o j e c t w i l l c o n s i s t o f a double-bl ind randomized t r i a l and i s t o be c a r r i e d o u t by 2-4 c l i n i c a l c e n t e r s and a d a t a c o o r d i n a t i n g c e n t e r . An a t tempt w i l l be made t o r e c r u i t a t l e a s t 5,400 e l i g i b l e women so t h a t t h e r e w i l l be a f i n a l s t u d y sample of a t l e a s t 3,600. O f f e r o r s w i l l be expec ted t o i n c l u d e p l a n s f o r t h e r e c r u i t m e n t o f e l i g i b l e m i n o r i t y women f o r t h i s s t u d y . The d a t a necessary f o r t h i s p r o j e c t w i l l be c o l l e c t e d through q u e s t i o n n a i r e s , i n t e r v i e w s , and c l i n i c a l and l a b o r a t o r y examinat i o n s .

T h i s announcement f o r t h e c l i n i c a l c e n t e r s t o perform t h e t r i a l s is a new s o l i c i t a t i o n . S o l i c i t a t i o n f o r p r o p o s a l s f o r t h e d a t a c o o r d i n a t i n g c e n t e r for t h i s p r o j e c t w i l l be announced under a d i f f e r e n t Request f o r Proposa ls (RFP).T h i s i s s u a n c e o f t h e c l i n i c a l t r i a l RFP w i l l be on o r about November 6 , 1989,and t h e p r o p o s a l s are due by 4:OO pm (Local T i m e ) , January 10 , 1990. Those o r g a n i z a t i o n s d e s i r i n g a copy o f t h e above RFP may send t h e i r w r i t t e n r e q u e s t with two s e l f - a d d r e s s e d m a i l i n g l a b e l s t o :

Mrs. Lynn S a l o , Cont rac t S p e c i a l i s t N I C H D , OGC, CMS Execut ive P l a z a North, Room 515 9000 R o c k v i l l e P ike Bethesda, Maryland 20892

A l l r e s p o n s i b l e s o u r c e s may submit a proposa l for c o n s i d e r a t i o n . T h i s adver t i sement does n o t commit t h e Government t o award a c o n t r a c t .

THE DATA COORDINATING CENTER FOR THE N I C H D TRIAL OF CALCIUM SUPPLEMENTATION I N PREGNANCY FOR THE PREVENTION OF PREECLAMPSIA AND PRETERM BIRTH

RFP AVAILABLE: NICHD-PRP-90-07

P.T. 34; K.W. 0715160, 0745027, 0710095r 0715115, 0755015, 0755058

N a t i o n a l I n s t i t u t e o f Chi ld Heal th and Human Development

The N a t i o n a l I n s t i t u t e of Child Heal th and Human Development is s e e k i n g o r g a n i z a t i o n s t h a t a r e smal l b u s i n e s s e s t o c o o r d i n a t e a c l i n i c a l t r i a l o f Calcium Supplementat ion i n Pregnancy for t h e Prevent ion o f Preeclampsia and Preterm B i r t h . T h i s p r o j e c t c o n s i s t s o f a double-bl ind, randomized t r i a l and i s t o be c a r r i e d o u t by 2-4 c l i n i c a l c e n t e r s and a d a t a c o o r d i n a t i n g c e n t e r . An a t tempt w i l l be made t o r e c r u i t a t l eas t 5,400 e l i g i b l e women so t h a t t h e r e w i l l be a f i n a l s t u d y sample o f a t l e a s t 3,600. The Data Coordina t ing Center must be c a p a b l e o f p r o v i d i n g d a i l y a s s i s t a n c e t o t h e c l i n i c a l i n v e s t i g a t o r s a t t h e d a t a c o l l e c t i o n si tes, i n s u r i n g t h a t t h e p r o t o c o l is fol lowed, a s s u r i n g t h e q u a l i t y o f d a t a c o l l e c t e d , and p r o v i d i n g feedback t o t h e s t e e r i n g committee o r t h e P r o j e c t Officer on s t u d y p r o g r e s s w i t h i n a s h o r t t u r n around t i m e .

T h i s announcement f o r t h e Data Coordina t ing Center i s a new s o l i c i t a t i o n . The c l i n i c a l t r i a l s p r o j e c t w i l l be announced under a d i f f e r e n t Request f o r Proposa ls (RFP). The i s s u a n c e o f t h e Data Coordina t ing Center RFP w i l l be on o r about November 6 , 1989, and t h e p r o p o s a l s a r e due by 4:OO pm (Local T i m e ) , January 10, 1990. Those o r g a n i z a t i o n s d e s i r i n g a copy o f t h e above r e f e r e n c e d RFP may send t h e i r w r i t t e n r e q u e s t wi th two s e l f - a d d r e s s e d mai l ing l a b e l s t o :

Mrs. Lynn S a l o , Cont rac t S p e c i a l i s t N I C H D , OGC, CMS Execut ive P l a z a North. Room 515 9 0 0 0 R o c k v i l l e P ike Bethesda, Maryland 20892

Vol. 18, No. 39, November 3, 1989 - Page 1

(THIS I S A 100% SET-ASIDE FOR SMALL BUSINESS, SIC 7379-- Computer r e l a t e d s e r v i c e s n o t o t h e r w i s e c l a s s i f i e d . ) A l l r e s p o n s i b l e smal l b u s i n e s s s o u r c e s maysubmit a p r o p o s a l which w i l l be c o n s i d e r e d . T h i s adver t i sement does n o t commit t h e Government t o award a c o n t r a c t .

I N VIVO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST H I V

RFP AVAILABLE: NIH-NIAID-DAIDS-90-24

P.T. 34; K . W . 0745005, 0755010, 0715008, 0755060

N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

The Developmental T h e r a p e u t i c s Branch o f t h e Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases ( N I A I D ) , N I H , h a s a requirement f o r c o n t r a c t a s s i s t a n c e t o p r o v i d e i n v i v o t e s t systems f o r s c r e e n i n g combinat ions o f t h e r a p i e s a g a i n s t H I V . E v a l u a t i o n systems may use H I V o r o t h e r animal r e t r o v i r u s sys tems. These model systems w i l l be used by t h e D i v i s i o n o f AIDS o f t h e N I A I D i n i ts e f f o r t s t o assist i n t h e development o f a n t i - i n f e c t i v e drugs and t h e r a p i e s , t o b e t t e r unders tand i n t e r a c t i o n s between t h e r a p e u t i c a g e n t s (synergy, adverse effect , e t c . ) , and t o opt imize a d m i n i s t r a t i o n o f combined t h e r a p i e s ( r o u t e , schedule , e t c . ) . The model systems t o be i n v e s t i g a t e d should re f lec t t h e c l i n i c a l , immunological and v i r o l o g i c a l a s p e c t s of H I V i n f e c t i o n i n humans. It i s a n t i c i p a t e d t h a t t h i s in format ion w i l l pe rmi t t h e improved t r e a t m e n t o f H I V i n f e c t i o n s i n humans.

T h i s i s an announcement f o r an a n t i c i p a t e d Request f o r P r o p o s a l s ( R F P ) . RFP-NIH-NIAID-DAIDS-90-24 s h a l l be i s s u e d on o r about November 3, 1989, w i t h a c l o s i n g d a t e t e n t a t i v e l y s e t f o r January 11, 1990. The I n s t i t u t e e x p e c t s t o make approximately two awards from t h i s s o l i c i t a t i o n .

Requests f o r t h e RFP should be d i r e c t e d i n w r i t i n g t o :

Mary Anne G l i t z Contrac t Management Branch Contro l Data B u i l d i n g , 6003 Execut ive Blvd. , Room 214P N a t i o n a l I n s t i t u t e of A l l e r g y and I n f e c t i o u s D i s e a s e s N a t i o n a l I n s t i t u t e s o f Heal th Bethesda, Maryland 20892 Telephone: (301) 496-1642

To r e c e i v e a copy o f t h e RFP, p l e a s e supply t h i s o f f i c e w i t h 2 s e l f - a d d r e s s e d m a i l i n g l a b e l s . A l l i n q u i r i e s must be i n w r i t i n g . A l l r e s p o n s i b l e s o u r c e s may submit a p r o p o s a l which w i l l be c o n s i d e r e d .

T h i s adver t i sement does n o t commit t h e Government t o award a c o n t r a c t .

I N VITRO TEST SYSTEMS FOR COMBINED CHEMOTHERAPIES AGAINST H I V

RFP AVAILABLE: NIH-NIAID-DAIDS-90-23

P.T. 34; K.W. 0745005, 0755010, 0715008, 0755060

N a t i o n a l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

The Developmental T h e r a p e u t i c s Branch o f t h e N a t i o n a l I n s t i t u ’ s o f A l l e r g y and I n f e c t i o u s D i s e a s e s ( N I A I D ) , N I H , h a s a requirement f o r contracl : a s s i s t a n c e t o provide i n v i t r o t e s t systems f o r s c r e e n i n g combinat ions of t h e r l p i e s a g a i n s t H I V . E v a l u a t i o n systems must be a s t a n d a r d i z e d c e l l - b a s e d a s s a y u s i n g H I V i n f e c t i o n o f t -ce l l l i n e s , macrophages and f r e s h p e r i p h e r a l blood lymphocytes; e v a l u a t i o n s m a s t i n c l u d e e f f i c a c y and c y t o t o x i c i t y measures. A d d i t i o n a l e v a l u a t i o n s i n c l u d e c e l l uptake, mechanisms o f antagonism o r synergy, c e l l u l a r metabolism, immunological effects , and e f f i c a c y a g a i n s t d r u g - r e s i s t a n t s t r a i n s o f v i r u s . These model systems w i l l be used by t h e D i v i s i o n o f AIDS o f t h e N I A I D i n i ts e f f o r t s t o assist i n t h e development o f a n t i - i n f e c t i v e d r u g s and t h e r a p i e s , t o b e t t e r unders tand i n t e r a c t i o n s between t h e r a p e u t i c a g e n t s (synergy, a d v e r s e e f fec t , e t c . ) , and t o unders tand mechanisms o f a c t i o n o f t h e r a p e u t i c a g e n t s . The model systems should be r e l e v a n t t o t h e r a p i e s d i r e c t e d a g a i n s t H I V i n f e c t i o n i n humans and p r o v i d e informat ion t h a t w i l l permi t t h e improved t r e a t m e n t o f p a t i e n t s i n f e c t e d w i t h H I V .

T h i s is an announcement f o r an a n t i c i p a t e d Request f o r Proposa l (RFP).RFP-NIH-NIAID-DAIDS-90-23 w i l l be i s s u e d on o r about November 3, 1989, w i t h a c l o s i n g d a t e t e n t a t i v e l y set f o r January 10, 1990. The I n s t i t u t e e x p e c t s t o make approximately t h r e e awards from t h i s s o l i c i t a t i o n .

Vol. 18, No. 39, November 3, 1989 - Page 2

Requests f o r t h e RFP s h a l l be d i r e c t e d i n w r i t i n g t o :

Mary Anne G l i t z Contrac t Management Branch Contro l Data B u i l d i n g , 6003 Execut ive Blvd . , Room 214P Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

"4 Nat iona l I n s t i t u t e s o f Heal th Bethesda, Maryland 20892 Telephone: (301) 496-1642

To r e c e i v e a copy o f t h e RFP, p l e a s e supply t h i s o f f i c e wi th 2 s e l f - a d d r e s s e d m a i l i n g l a b e l s . A l l i n q u i r i e s must be i n w r i t i n g . A l l r e s p o n s i b l e s o u r c e s may submit a p r o p o s a l which w i l l be c o n s i d e r e d .

T h i s adver t i sement does n o t commit t h e Government t o award a c o n t r a c t .

NOTICE - CLAUDE D . PEPPER GERIATRIC RESEARCH AND TRAINING CENTERS

P.T. 04, 44; K.W. 0710010, 0720005, 0710030

RFA: AG-89-06

A p p l i c a t i o n Receipt Date: February 15, 1990

N a t i o n a l I n s t i t u t e on Aging

The N a t i o n a l I n s t i t u t e on Aging's Geriatric Research and T r a i n i n g C e n t e r s g r a n t program (P301, announced i n t h e N I H Guide f o r Grants and C o n t r a c t s , Vol. 18, No. 27, August 11, 1989, i s r e t i t l e d t h e Claude D . Pepper Geriatric Research and T r a i n i n g C e n t e r s g r a n t program a s a t r i b u t e t o t h e memory of S e n a t o r Pepper.

A copy o f t h e complete Request f o r A p p l i c a t i o n s and t h e Geriatr ic Research and T r a i n i n g C e n t e r s G u i d e l i n e s may be o b t a i n e d from:

S t a n l e y L . S l a t e r , M . D . D i r e c t o r , Geriatric Research and T r a i n i n g ProgramG e r i a t r i c s Branch N a t i o n a l I n s t i t u t e on AgingB u i l d i n g 31, Room 5C27 9000 R o c k v i l l e P ike Bethesda, Maryland 20892 Telephone: ( 3 0 1 1 496-6761

O N G O I N G PROGRAM ANNOUNCEMENTS

INVESTIGATIONS INTO METHODS THAT REPLACE OR REDUCE VERTEBRATE ANIMALS USED I N RESEARCH, OR LESSEN THEIR PAIN AND DISTRESS

P.T. 34; K.W. 0755020, 0780010, 0780015, 0780020

N a t i o n a l I n s t i t u t e s o f Heal th Alcohol , Drug Abuse, and Mental Heal th Adminis t ra t ion

A p p l i c a t i o n Rece ip t Dates: February 1, June 1, October 1

BACKGROUND

The Nat iona l I n s t i t u t e s o f Heal th ( N I H ) and t h e Alcohol , Drug Abuse, and Mental Heal th Adminis t ra t ion i n v i t e s g r a n t a p p l i c a t i o n s f o r i n v e s t i g a t i o n si n t o r e s e a r c h methods t h a t do n o t use an imals , use fewer an imals , o r t h a t produce l e s s p a i n and d i s t r e s s i n an imals used f o r r e s e a r c h .

Biomedical r e s e a r c h w i l l be most e f f e c t i v e l y advanced by t h e cont inuous a p p l i c a t i o n o f a combinat ion o f models i n a complementary and i n t e r a c t i J e manner, r a t h e r t h a n by c o n c e n t r a t i n g on any one o r a few k i n d s o f model systems. Each system, whether mammalian o r nonmammalian, h a s i t s own uniqueadvantages and l i m i t a t i o n s . Because of a cont inued , wide i n t n r e s t i n t h e development o f nonmammalian models f o r biomedical r e s e a r c h , t h . p. ProgramAnnouncement, i s s u e d i n A p r i l 1988, is be ing r e i s s u e d t o encour , iea p p l i c a t i o n s i n t h i s area.

.I P r o p o s a l s f o r t h e s t u d y o f i n v e r t e b r a t e s , lower v e r t e b r a t e s , microorganisms,c e l l and t i s s u e c u l t u r e systems, o r mathematical approaches should be regarded as having t h e same p o t e n t i a l r e l e v a n c e t o biomedical r e s e a r c h as p r o p o s a l s f o r

Vol. 18, No. 39, November 3, 1989 - Page 3

work on systems t h a t a r e p h y l o g e n e t i c a l l y more c l o s e l y r e l a t e d t o humans. Experience i n d i c a t e s t h a t in format ion y i e l d e d by such systems can i n c r e a s e s u b s t a n t i a l l y t h e knowledge o f human f u n c t i o n .

Animals a r e e s s e n t i a l t o t h e advancement o f knowledge i n t h e biomedical s c i e n c e s . Nonmammalian r e s e a r c h methods can, and do, provide a d d i t i o n a l o p p o r t u n i t i e s t o advance our unders tanding o f b i o l o g i c a l p r o c e s s e s . For example, b i o l o g i c a l models o r model systems d e r i v e d from, o r c o n s i s t i n g o f ,nonmammalian organisms, o r c e l l and t i s s u e c u l t u r e systems, may providev a l u a b l e i n s i g h t s i n t o mechanisms o f b i o l o g i c a l f u n c t i o n s t h a t are more d i f f i c u l t t o o b t a i n from s t u d i e s o f whole v e r t e b r a t e an imals . Such t e c h n o l o g i e s o f t e n permi t s t u d i e s t h a t o t h e r w i s e would be imposs ib le t o perform. Mathematical modeling i s a n o t h e r u s e f u l i n v e s t i g a t i o n a l s t r a t e g ywhen c l o s e l y coupled t o b i o l o g i c a l exper imenta t ion , and t h e r e are o p p o r t u n i t i e s f o r mathematical modeling i n many a r e a s o f biomedical r e s e a r c h . Non-invasive exper imenta l t e c h n i q u e s , such as t h o s e commonly used f o r human s u b j e c t s , which permi t s t u d i e s of b i o l o g i c a l p r o c e s s e s i n i n t a c t an imals , can reduce t h e number o f exper imenta l an imals s i n c e m u l t i - s t e p phenomena can be observed i n a s i n g l e s u b j e c t .

Many s t r a t e g i e s a r e c u r r e n t l y i n p l a c e t o reduce t h e p a i n and d i s t r e s s of l a b o r a t o r y an imals ; however, new methods and t e c h n o l o g i e s are encouraged.

RESEARCH GOALS

Grant a p p l i c a t i o n s are r e q u e s t e d f o r p r o j e c t s t h a t w i l l i n c r e a s e t h e e x t e n t and depth o f knowledge needed t o develop methods o f biomedical r e s e a r c h t h a t :

o do n o t r e q u i r e t h e u s e of v e r t e b r a t e an imals o reduce t h e number o f v e r t e b r a t e an imals used i n r e s e a r c h o produce l e s s p a i n and d i s t r e s s i n v e r t e b r a t e an imals t h a n methods c u r r e n t l y used o v a l i d a t e o r demonstrate t h e r e l i a b i l i t y of non-animal methods o expand n o n - v e r t e b r a t e animal r e s e a r c h methods t h a t have been found v a l i d and r e l i a b l e

MECHANISM OF SUPPORT

The suppor t mechanism f o r t h i s program w i l l be t h e t r a d i t i o n a l ,. i n v e s t i g a t o r - i n i t i a t e d r e s e a r c h p r o j e c t g r a n t . Under t h i s mechanism, t h e

a p p l i c a n t w i l l p l a n , d i r e c t , and c a r r y o u t t h e r e s e a r c h program. The p r o j e c tp e r i o d d u r i n g which t h e r e s e a r c h w i l l be conducted should a d e q u a t e l y r e f l ec t t h e t i m e r e q u i r e d t o accomplish t h e s t a t e d g o a l s and be c o n s i s t e n t w i t h t h e p o l i c y f o r g r a n t s u p p o r t . Support w i l l be provided f o r up t o f i v e y e a r s(renewable f o r subsequent p e r i o d s ) s u b j e c t t o t h e a v a i l a b i l i t y o f funds and p r o g r e s s achieved .

Research g r a n t a p p l i c a t i o n s may b e submi t ted by both n o n p r o f i t and prof i t -making o r g a n i z a t i o n s and i n s t i t u t i o n s , S t a t e o r l o c a l governments and t h e i r a g e n c i e s , and e l i g i b l e a g e n c i e s of t h e Federa l Government.

APPLICATIONS AND REVIEW PROCEDURES

A p p l i c a t i o n s i n response t o t h i s s o l i c i t a t i o n w i l l be a p p r o p r i a t e l y p e e rreviewed f o r s c i e n t i f i c and t e c h n i c a l mer i t . They w i l l be judged on t h e o v e r a l l s c i e n t i f i c merit o f t h e proposed r e s e a r c h , p o t e n t i a l s i g n i f i c a n c e of t h e r e s e a r c h f i n d i n g s , adequacy of methodology, a v a i l a b i l i t y of n e c e s s a r yf a c i l i t i e s , and t h e q u a l i f i c a t i o n s o f t h e r e s e a r c h team. A secondary review f o r p o l i c y and program r e l e v a n c e t o t h e r e s e a r c h needs and miss ions o f t h e Bureau, I n s t i t u t e , o r D i v i s i o n t o which t h e p r o p o s a l i s a s s i g n e d w i l l be made by t h e r e s p e c t i v e N a t i o n a l Advisory Counci l s .

A p p l i c a t i o n s should b e completed u s i n g PHS Form 398, "Appl ica t ion f o r P u b l i c Heal th S e r v i c e Grant". Send t h e o r i g i n a l and s i x c o p i e s of t h e a p p l i c a t i o n

D r

t o t h e D i v i s i o n o f Research Grants , N I H , as d e s c r i b e d i n PHS Form 398.

It is important t h a t a p p l i c a n t s e n t e r "NONMAMMALIAN RESEARCH METHODS" on l i n e 2 f o r t h e response t o s p e c i f i c program announcement.

A p p l i c a n t s a r e encouraged t o c o n t a c t D r . R a m m a t t h e a d d r e s s below p r i o r t o s u b m i t t i n g an a p p l i c a t i o n :

D r . Louise E . Ramm B i o l o g i c a l Models and M a t e r i a l s Resources Program, DRRINIH Westwood Bui ld ing , Room 853 5333 Westbard Avenue Bethesda, Maryland 20892

Vol. 18, No. 39, November 3, 1989 - Page 4

.W

FOR FURTHER INFORMATION CONTACT:

Div is ion o f Research Resources D r . Louise E . Ramm B i o l o g i c a l Models and M a t e r i a l s Resources ProgramWestwood Bui ld ing , Room 853 Bethesda, Maryland 20892 Telephoner (301) 496-5175

Nat iona l Cancer I n s t i t u t e D r . J . A . R . Mead Chief , Grants and C o n t r a c t s Opera t ions Branch Developmental T h e r a p e u t i c s ProgramD i v i s i o n of Cancer Treatment Execut ive P l a z a North, Room 832 Bethesda, Maryland 20892 Telephone: (301) 496-8783

N a t i o n a l Center f o r Nursing Research D r . J a n Heinr ich D i r e c t o r , Extramural ProgramsB u i l d i n g 3 8 A , Room 2BE17 Bethesda, Maryland 20892 Telephone: (301) 496-0523

N a t i o n a l Eye I n s t i t u t e D r . Michael Oberdorfer Program D i r e c t o r , Amblyopia and V i s u a l Process ing Bui ld ing 31, Room 6A47 Bethesda, Maryland 20892 Telephone: (301 ) 496-5301

Nat iona l I n s t i t u t e of A l l e r g y and I n f e c t i o u s Diseases D r . Luz A . F r o e h l i c h Deputy D i r e c t o r , Extramural A c t i v i t i e s ProgramWestwood Bui ld ing , Room 703 Bethesda, Maryland 20892 Telephone: (301) 496-7688

Nat iona l I n s t i t u t e on AgingD r . D e W i t t Hazzard Head, Resource DevelopmentBiomedical Research and C l i n i c a l Medicine Bui ld ing 31, Room 5C21 Bethesda, Maryland 20892 Telephone: (301) 496-6402

N a t i o n a l I n s t i t u t e of A r t h r i t i s and Musculoske le ta l and Skin Diseases D r . S teven J . Hausman Deputy D i r e c t o r , Extramural ProgramWestwood Bui ld ing , Room 403 Bethesda, Maryland 20892 Telephoner (301) 496-7495

Nat iona l I n s t i t u t e of Chi ld Heal th Ms. Hildegard TopperS p e c i a l A s s i s t a n t Office o f t h e D i r e c t o r B u i l d i n g 31, Room 2A04 Bethesda, Maryland 20892 Telephone: (301 ) 496-0104

and Human Development

Nat iona l I n s t i t u t e of Diabetes and D i g e s t i v e and Kidney Diseases D r . Walter S t o l z D i r e c t o r , D i v i s i o n of Extramural A c t i v i t i e s Westwood Bui ld ing , Room 657 Bethesda, Maryland 20892 Telephone: (301) 496-7277

Nat iona l I n s t i t u t e of Dental Research D r . G . Wayne WrayDeputy D i r e c t o r , Extramural ProgramWestwood Bui ld ing , Room 502 Bethesda, Maryland 20892 Telephoner (301 ) 496-7748

Vol. 18, No. 39, November 3, 1989 - Page 5

N a t i o n a l I n s t i t u t e of Environmental Heal th S c i e n c e s D r . J e r r v Robinson S c i e n t i f i c Programs Branch D i v i s i o n o f Extramural Research and T r a i n i n g P.O. Box 12233 Research T r i a n g l e Park, North C a r o l i n a 27729 Telephone: ( 9 1 9 ) 541-7724 o r

(FTS NUMBER) 8-629-7724

N a t i o n a l I n s t i t u t e o f General Medical S c i e n c e s D r . David Wolff Deputy A s s o c i a t e D i r e c t o r f o r Program A c t i v i t i e s Westwood Bui ld ing , Room 955 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-7063

N a t i o n a l H e a r t , Lung, and Blood I n s t i t u t e-D r . Henry G . Roscoe Deputy D i r e c t o r , D i v i s i o n of Extramural Affairs Westwood B u i l d i n s , Room 7A17 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-7225

N a t i o n a l I n s t i t u t e of Neurologica l D i s o r d e r s and S t r o k e D r . Eugene S t r e i c h e r D i r e c t o r , D i v i s i o n o f Fundamental Neurosciences Federa l B u i l d i n g , Room 916 Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-5745

N a t i o n a l I n s t i t u t e on Alcohol Abuse and Alcoholism D r . Helen Chao Acting Deputy D i r e c t o r , D i v i s i o n of Basic Research Parklawn B u i l d i n g , Room 14C-10 5600 F i s h e r s Lane R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-2530

N a t i o n a l I n s t i t u t e on Drug Abuse D r . Roger Brown Chief , Neuroscience Research Branch D i v i s i o n o f P r e c l i n c i a l Research Parklawn B u i l d i n g , Room 1 OA-31 5600 F i s h e r s Lane R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-6975

N a t i o n a l I n s t i t u t e of Mental Heal th D r . Ronald Schoenfeld Act ing Chief , Neurosciences Research Branch 5600 F i s h e r s Lane, Room 11-105 R o c k v i l l e , Maryland 20857 Telephone: ( 3 0 1 ) 443-3948

Vol. 18 , No. 39 , November 3, 1989 - Page 6 *U. S. C O V E R N M N T P R I N T I N G 0Ff ICE:1989-261-138 :'3332'