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DepartmentofPopulationMedicine

POPM*3240–EpidemiologyWinter2018

CourseCoordinator/Instructor

Dr.AndriaJones-BittonDepartmentofPopulationMedicineOVCStewartBuilding,Room2525

GraduateTeachingAssistants

MayKamleh(PhDCandidate) BrianaHagen(PhDStudent) CONTACTINFORMATION:Email:teachepi@uoguelph.caOfficeHours(startJan.15th)–inOVCStewartBuilding(www.uoguelph.ca/campus/map/stewart/)

Day Time Who PlaceWednesdays 3:00–4:00pm Kamleh/Hagen Room2527Mondays 9:30–10:30am Jones-Bitton Room2525*AdditionalOfficeHourstobeheldaroundmidtermandfinalexaminations–dates/timeswillbeannouncedonCourselink

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Classschedule:Mondays,Wednesdays,Fridays–8:30to9:20amClasslocation:AlexanderHall,Room200(ALEX200)Calendardescription:Thiscoursepresentsthebasicconceptsofhealthanddiseaseinpopulations.Methodsusedin descriptive and analytic epidemiological studies, including the design, analysis andinterpretationofresultsforobservationalstudiesandfieldtrialsarepresented.Coursegoals:Thegoalsofthiscoursearetopresenttheepidemiologicalprinciplesandconceptsrequiredforthecollection,analysis,andinterpretationofhealthdataatthepopulationlevel.Coursecoordinator’sgoals:Tohelpfosterexcitementandinterestinepidemiology,inaclassroomenvironmentthatispositive,engagingandintellectuallychallenging.Courseobjectives:Attheendofthiscourse,thelearnershouldbeableto:

1. Describetheapplicationofepidemiologytodiseasecontrol,outbreakinvestigation,healthresearch,andcurrentpublichealth,animalhealthandOneHealthissues;

2. Identify, define, calculate, and interpret common measures of association (riskdifference,attributableriskexposed,populationattributablerisk,relativerisk,oddsratios) and measures of disease frequency (prevalence, risks, rates) used inepidemiologicalresearch,andcitetheirstrengthsandlimitations;

3. Describe how to select appropriately-sized samples from populations for surveysandobservationalstudies;

4. Discuss disease causation, statistical associations and causal inference, and rankcommonstudydesignsbytheirabilitytoestablishcausality;

5. Discuss the use of screening tests, identify the criteria used to evaluate tests, andexplain epidemiological sensitivity, specificity, predictive values and agreement,includinghowtocalculatethesemeasures;

6. Discuss thedesign,methodologyand strengths/limitationsof eachof the commonobservationalandexperimentalstudytypesinepidemiology;

7. Identify and discuss the potential effects of common biases observed inepidemiological research, including various selection biases, misclassification andconfounding;

8. Explain the concepts of incubation and latent periods, state transition models,effectiveandbasicreproductivenumbers,andgiveexamplesofstrategiestoreducethelatterfordiseasecontrol.

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Evaluationmethods: PercentageofFinalGradeOnlineQuizzes 10MidtermExam1 25MidtermExam2 25FinalExam 40§ Online Quizzes (5 quizzes, each 2%, for a total of 10% of final grade; quizwithlowestmark[includingmissedquiz]willbedropped)

These quizzes are short, multiple choice quizzes available on Courselink during thefollowingtimeperiods,andcoveringthefollowingtopics:

Quiz DateAvailable

(asof9:30am)DateDue

(by11:59pm)SessionsCovered

1 WednesdayJan.17

TuesdayJan.23 1to5inclusive

2 FridayJan.26

ThursdayFeb.1 6to9inclusive

3 MondayFeb.5

SundayFeb.11 10to13inclusive

4 FridayMar.2

ThursdayMar.8 14to21inclusive

5 MondayMar.12

SundayMar.18 22to25inclusive

6 MondayMar.26

SundayApr.1 26to31inclusive

The quizzes are open-book (i.e. feel free to use your notes/text) but are independentassessments(i.e.theyaretobedoneonyourown).Note:doingordiscussingthequizzeswithothers,screen-capturingorrecordingquizquestionsviaothermeans,and/orsharingthequizquestionswithothersisprohibitedandconsideredAcademicMisconduct.NOTE:Be sure to save every answer as younavigate througheachquiz. Thatway, youranswerswill be on record should you have a technical problem that prevents you fromfinishingyourquiz. Ifyoudohavea technicalproblem,youmustemail thecourseemailaccount(teachepi@uoguelph.ca)immediatelytoinformusoftheproblem.NOTE:TherewillbeNOopportunitytowriteamissedonlinequiz.OnlyFIVEquizzeswillcounttowardsyourfinalgrade- thequizwiththe lowestmark(includingnon-completedquiz)willbedroppedandnotcounttowardsyourfinalgrade.

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§ MidtermExam1(25%offinalgrade)–SaturdayFebruary10–3:30pmto4:30pminMacNaughton105&113

This examination covers material from Sessions 1-13 inclusive. Be sure to bring yourUniversity of Guelph Student ID, own pen, pencil, eraser, and calculator - sharing ofcalculatorswillNOTbepermittedandcalculatorswillNOTbeprovidedtoyou.Thisexamwillconsistofmultiplechoice,shortanswer,andshortcalculationquestions.§ MidtermExam2(25%offinalgrade)–FridayMarch9–6:30pmto7:30pminRichardsBuilding2520&2529

This examination covers material mainly from Sessions 14-23 inclusive, but previousmaterialmayalsostillbetested.BesuretobringyourUniversityofGuelphStudentID,ownpen, pencil, eraser, and calculator - sharing of calculators will NOT be permitted andcalculatorswillNOTbe provided to you. This examwill consist ofmultiple choice, shortanswer,andshortcalculationquestions.§ FinalExam(40%offinalgrade)–FridayApril20–11:30amto1:30pm.RoomTBA*Thisexaminationwill covermaterial spanningall sessionsof the course.BesuretobringyourUniversityofGuelphStudentID,pen,pencil,eraser,andcalculator-sharingofcalculatorswillNOTbepermittedandcalculatorswillNOTbeprovidedtoyou.Thisexamwillconsistofmultiplechoice,shortanswer,andshortcalculationquestions.*PleasecheckWebAdvisor,asitisprovidesofficialUniversityexamscheduling

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Coursetextbook(stronglyrecommended):Epidemiology5thedition,byLeonGordis,ElsevierSaundersCompany,Philadelphia:2014.ISBN:978-1-4557-3733-8.- Available in University Bookstore. Note: Purchase also allows online access &

interactiveextras- AlsoonReserveinUniversityofGuelphlibrary- Yes,olderversionsarefine–chapters/pagenumberswilldifferthough

OtherRecommendedReferences(onreserveinUniversityLibrary):

• MedicalEpidemiology,4thedition;GreenbergRS,DanielsSR,FlandersWD,EleyJW,BoringJR.LangeMedicalBooks/McGraw-Hill,NewYork,NY:2005

• VeterinaryEpidemiology:PrinciplesandMethods:MartinSW,MeekAH,WillebergP.IowaStateUniversityPress,Ames,IW:1987

• Veterinary Epidemiological Research, 2nd edition: Dohoo IR,Martin SW, Stryhn H.VERInc.,Charlottetown,PEI:2009

• Population Health: Concepts and Methods, 2nd edition, by Young, TK. (OxfordUniversityPress,NewYork,NY:2005).

• ADictionaryofEpidemiology,4thedition;Last JMeditor. (OxfordUniversityPressNewYork,NY:2001).

OtherSuggestedReferences(forthereallykeen):

• Methods in Epidemiologic Research: Dohoo I, Martin W, Stryhn H. (VER Inc.,Charlottetown,PEI:2012)

• Critical Appraisal of Epidemiological Studies and Clinical Trials, by Elwood M.(OxfordUniversityPress,NewYork,NY:2002)

• Epidemiology - an introductory text, 2nd edition, byMausner JS&Kramer S. (WBSaunders:Toronto;1985).

• Epidemiology inMedicine,byHennekensCH&Buring JE. (Little&Brown,Boston:1987)

• EpidemiologyKeptSimple:anIntroductiontoClassicandModernEpidemiology,byGerstmanBB.(Wiley,NewYork,NY:1998)

• Epidemiology:anIntroduction,byRothmanKJ.(OxfordUniversityPress,NewYork,NY:2002)

• ClinicalEpidemiology:aBasicScienceforClinicalMedicine,2ndedition,bySackettDL,HaynesRB,GuyattGH,andTugwellP.(Little&Brown,Toronto:1991)

• PDQ Epidemiology, 2nd edition, by Streiner DL & Norman GR. (Mosby, Toronto:1996)

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Course&universitypoliciesRecordingofMaterialsPresentationswhicharemade in relation to coursework—including lectures—cannotberecorded or copied without the permission of the presenter, whether the instructor, aclassmateorguestlecturer.Materialrecordedwithpermissionisrestrictedtouseforthatcourseunlessfurtherpermissionisgranted.E-mailcommunicationAsperuniversityregulations,allstudentsarerequiredtochecktheirUniversityofGuelph<uoguelph.ca> e-mail account regularly. E-mail is the official route of communicationbetweentheUniversityanditsstudents.WhenyoucannotmeetacourserequirementWhen you find yourself unable to meet an in-course requirement because of illness orcompassionatereasons,pleaseadvisethecourseinstructor(ordesignatedperson,suchasateaching assistant) in writing, with your name, id#, and e-mail contact. See theundergraduate calendar for information on regulations and procedures for AcademicConsideration:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-ac.shtmlRe-gradingpolicyThefollowingpolicyisinplaceforALLrequestsforre-grading(NOexceptions):Marking schemes will be made available on Courselink for all midterm exams andassignments.Consult themarkingschemeandcarefully/thoughtfully reviewyouranswersandmarksreceived.Ifyoubelieveanerrorwasmade,writeashortandspecificstatementindicatingwhyyouthinkthereisanerror(i.e.youmustclearlyjustifythere-grading).Attach the statement to the original exam/assignment, and re-submit this to Dr. Jones-Bittonbydelivering it toherofficemailbox in thePopulationMedicinemainofficeof theOVC Stewart Building within one week (i.e. by 12:30pm on 7th calendar day) after theassignments/midtermsarereturnedin-class.Note:allre-gradingwillbedonebyDr.Jones-Bitton;materialswillbere-gradedinentiretyandallappropriateadjustmentsmade.StudentswillbenotifiedthroughCourselinkonthestatusoftheirre-graderequest.

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DropdateThelastdatetodropone-semestercourses,withoutacademicpenalty,isthe40thclassday(forWinter2018, this isFridayMarch 9, 2018).Refer to theGraduateCalendar for thecompletescheduleofdates:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c03/index.shtmlFor regulations and procedures for Dropping Courses, see the Undergraduate Calendar:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-drop.shtmlAccessibilityTheUniversity of Guelph is committed to creating a barrier-free environment. Providingservicesforstudentsisasharedresponsibilityamongstudents,faculty,andadministrators.Thisrelationshipisbasedonrespectof individualrights,thedignityoftheindividualandthe University community’s shared commitment to an open and supportive learningenvironment.Studentsrequiringserviceoraccommodation,whetherduetoan identified,on-goingdisabilityorashort-termdisabilityshouldcontactStudentAccessibilityServices(SAS),formerlytheCentreforStudentswithDisabilities,assoonaspossible.Formoreinformation,contactSASat519-824-4120ext.56208oremailcsd@uoguelph.caorseethewebsite:https://www.uoguelph.ca/csd/AcademicMisconductThe University of Guelph is committed to upholding the highest standards of academicintegrityandit istheresponsibilityofallmembersoftheUniversitycommunity–faculty,staff, and students – to be aware ofwhat constitutes academicmisconduct and to do asmuch as possible to prevent academic offences from occurring. University of Guelphstudents have the responsibility of abiding by the University's policy on academicmisconduct regardless of their location of study; faculty, staff and students have theresponsibilityofsupportinganenvironmentthatdiscouragesmisconduct.Studentsneedtoremain aware that instructors have access to and the right to use electronic and othermeansofdetection.Please note: Whether or not a student intended to commit academic misconduct is notrelevant for a finding of guilt. Hurried or careless submission of assignments does notexcuse students from responsibility for verifying the academic integrity of their workbeforesubmittingit.Studentswhoare inanydoubtastowhetheranactionontheirpartcouldbeconstruedasanacademicoffenceshouldconsultwithafacultymemberorfacultyadvisor.TheAcademicMisconductPolicyisdetailedintheUndergraduateCalendar:https://www.uoguelph.ca/registrar/calendars/undergraduate/current/c08/c08-amisconduct.shtml

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Formoredetails,youarestronglyencouragedtoconsulttheUniversity’sAcademicIntegritytutorial,ashortbuthighlyusefulonlinetutorialtohelpinformandclearcommonmisconceptionsregardingacademicmisconduct:http://www.academicintegrity.uoguelph.ca/ResourcesThe Graduate Calendar is the source of information about the University of Guelph’sprocedures,policiesandregulationsthatapplytograduateprograms:http://www.uoguelph.ca/registrar/calendars/graduate/current/

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POPM*3240LectureScheduleWinter2018(Maybesubjecttochange)

Continuednextpage…

Session Date Topic&Notes

Lecturer

1 Jan.8 IntroductiontoCourse Dr.Jones-Bitton2 Jan.10 IntroductiontoEpi&HistoricalApproaches Dr.Jones-Bitton3 Jan.12 FoundationsinHealth&DiseaseTransmission Dr.Jones-Bitton4 Jan.15 FoundationsinHealth&DiseaseTransmission Dr.Jones-Bitton5 Jan.17 StatisticalAnalysisofEpidemiologicalData Dr.Jones-Bitton6 Jan.19 SamplingI Dr.Jones-Bitton7 Jan.22 SamplingII Dr.Jones-Bitton8 Jan.24 Screening&DiagnosticTestsI Dr.Jones-Bitton9 Jan.26 Screening&DiagnosticTestsII Dr.Jones-Bitton10 Jan.29 EpidemiologyinPublicHealth Dr.Papadopoulos11 Jan.31 Bias&CausationI Dr.Jones-Bitton12 Feb.2 Bias&CausationII Dr.Jones-Bitton13 Feb.5 Bias&CausationIII Dr.Jones-Bitton14 Feb.7 MeasuresofAssociation&EffectI Dr.Jones-Bitton15 Feb.9 IndependentStudyformidtermonSaturday ---- Feb.10 MIDTERMI

3:30pmto4:30pm[MACN105&113]

Dr.Jones-Bitton

16 Feb.12 MeasuresofAssociation&EffectII Dr.Jones-Bitton17 Feb.14 Cross-SectionalStudies M.Kamleh18 Feb.16 CohortStudiesI Dr.Jones-Bitton-- Feb.19-

23WINTERBREAK–NOCLASS

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19 Feb.26 CohortStudiesII Dr.Jones-Bitton20 Feb.28 InterventionStudies:RandomizedControlledTrialsI Dr.D.Kelton21 Mar.2 InterventionStudies:RandomizedControlledTrialsII Dr.D.Kelton22 Mar.5 Case-ControlStudiesI Dr.Jones-Bitton23 Mar.7 Case-ControlStudiesII Dr.Jones-Bitton24

Mar.9

MIDTERMII6:30pmto7:30pm[RICH2520&2529]

40thClassDay–lastdaytodropone-semestercourses

Dr.Jones-Bitton

25 Mar.12 InterpretingMultivariableModels

Dr.Jones-Bitton

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Session Date Topic&Notes

Lecturer

26 Mar.14 CriticalAppraisal B.Hagen27 Mar.16 InfectiousDiseaseModelling R.Milwid28 Mar.19 MeasuresofDiseaseFrequencyI Dr.Jones-Bitton29 Mar.21 MeasuresofDiseaseFrequencyII Dr.Jones-Bitton30 Mar.23OutbreakInvestigationsI Dr.Jones-Bitton31 Mar.26 OutbreakInvestigationsII Dr.Jones-Bitton32 Mar.28 EcosystemApproachestoHealth Dr.S.Harper-- Mar.30 HOLIDAY–NOCLASS --33 Apr.2 DiseaseSurveillance A.Swirski34 Apr.4 SystematicReviews&Meta-Analysis Dr.JanSargeant35 Apr.6 Review Dr.Jones-Bitton-- Apr.20 FINALEXAM

11:30amto1:30pmRoomTBAonWebAdvisor

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Readings

AnoteregardingReadings:“needtoknow”topics(i.e.thosethatwillbeincludedinexaminations)arethosecoveredinclass.Thetextbookreadingsaremeanttohelpsolidifyorextendyourlearningandenableapplicationofthatmaterial.Assuch,theyarestronglyrecommended.Topicsthatarecoveredinthereadingsthatwerenottoucheduponinlecturewillnotbeconsidered“testable”material.

Session Topic&Notes Readings

1 IntroductiontoCourse CourseSyllabus2 IntroductiontoEpi&HistoricalApproaches Chapter1,Gordistext3 FoundationsinHealth&DiseaseTransmission Chapter2,Gordistext4 FoundationsinHealth&DiseaseTransmission5 StatisticalAnalysisofEpidemiologicalData Reviewprevious

STAT*2040/otherSTATnotes

6 SamplingI Chapter8,Gordistext(uptop.160)7 SamplingII

8 Screening&DiagnosticTestsI Chapter5,Gordistext9 Screening&DiagnosticTestsII10 EpidemiologyinPublicHealth --11 Bias&CausationI Chapters14&15,Gordis

text12 Bias&CausationII13 Bias&CausationIII

14&16 MeasuresofAssociationIMeasuresofAssociationII

Chapters11&12,Gordistext

15 MIDTERM1 --

17 Cross-SectionalStudies p.210–212,Gordistext18 CohortStudiesI Chapter9,Gordistext19 CohortStudiesII20 InterventionStudies:RandomizedControlledTrialsI Chapters7&8,Gordis

text21 InterventionStudies:RandomizedControlledTrialsII22 Case-ControlStudiesI Chapter10

(top.202)&Chapter13,Gordistext

23 Case-ControlStudiesII

24 MIDTERM240thClassDay–lastdaytodroponesemestercourses

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25 InterpretingMultivariableModels

Tripepietal.,2011(onCourselink)

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26 CriticalAppraisal Young&Solomonpaper(onCourselink)

27 InfectiousDiseaseModelling TBD-SeeCourselink28 MeasuresofDiseaseFrequencyI Chapter3,Gordistext29 MeasuresofDiseaseFrequencyII30 OutbreakInvestigationsI Reingoldpaper

(onCourselink)31 OutbreakInvestigationsII32 EcosystemApproachestoHealth TBD-SeeCourselink33 DiseaseSurveillance

TBD-SeeCourselink

34 SystematicReviews&Meta-Analysis TBD-SeeCourselink35 Review --