Department of Neurology · The Department of Neurology has a sustained commitment to excellence in...
Transcript of Department of Neurology · The Department of Neurology has a sustained commitment to excellence in...
Department of Neurology University of Pittsburgh School of Medicine
University of Pittsburgh Physicians
2017 Annual Report
Annual Report for the Period July 1, 2016 through June 30, 2017
TABLE OF CONTENTS
Department Overview/Mission/Activities 1
Department Educational and Clinical Activities 6
Department Division Activities 13
Department Institutes and National Center Affiliations 26
Research and Scholarly Activities 32
Faculty Summaries by Division
Cognitive and Behavioral Neurology 33
Epilepsy 34
General Neurology 41
Headache Division 45
Movement Disorders 48
Neurocritical Care 54
Neuroimmunology/MS 56
Neuromuscular Diseases 58
Neuro-Oncology 61
Research Division 62
Vascular Neurology 70
St. Margaret’s/McKeesport 75
Northshore – Erie 76
Heritage Valley 78
Faculty Service on Study Sections and Advisory Committees 80
Department Grant Activity 93
Grant and Funding Information 94
Faculty Research Collaborations 102
Faculty Honors, Editorial Service and Professional Affiliations 114
Faculty Mentoring and Teaching Contributions 139
Members of the Faculty 140
House Officers 142
Research Mentoring 146
Graduate Level Teaching, Mentorships, and Service 154
Medical School Teaching, Mentorships, and Service 156
Grand Rounds and Special Lectures 162
Bibliography 168
Financials 220
Department Overview, Mission and Activities
Introduction
The Department of Neurology continues to advance its mission, capabilities, and reputation for academic, clinical
and research activities. We strive to foster a working environment that supports and encourages the development
and growth of our faculty and staff's professional careers. From July 1, 2016 through June 30, 2017, there were 63
faculty members with primary appointments in Neurology and we expect additional faculty to join us next year. The
Department welcomed Drs. Erin Canale, Cynthia Kenmuir, Karuna Mandava, Robyn Massa, Ajitesh Ojha, Athur
Sonberg, Cosmin Sandulescu, and Ahmed Yassin with a variety of specialties in General Neurology, Epilepsy, and
Neuromuscular. Secondary appointments are held by Bing Wang, MD, PhD, Mary Ganguli, MD, William Klunk,
MD, PhD, Robert Sweet, MD, Cheryl Bernstein, MD, James Becker, PhD, Nancy Minshew, MD, Brian Jankowitz,
MD, Udai Pandey, PhD, and Charles Reynolds, MD in recognition of their clinical and research interactions with
the Department of Neurology. Many faculty members maintain secondary appointments throughout the University
providing clinical and research collaborations.
The Department continues to make significant advances in patient care, teaching, and clinical and basic research,
consistent with the mission of the Neurology Department, the School of Medicine, and University of Pittsburgh
Physicians (UPP). Key areas of excellence include the UPMC Stroke Institute; the UPMC Headache Center; the
Alzheimer’s disease Research Center (ADRC); the Pittsburgh Institute for Neurodegenerative Diseases (PIND); and
the American Parkinson Disease Association Advanced Center for Parkinson’s Research. The Neuromuscular,
Epilepsy, Headache, Cognitive and Behavioral Neurology, Stroke, Movement, Neuro-immunology/Multiple
Sclerosis, Women’s Neurology and General Neurology divisions provide key clinical diagnosis and treatment.
We are committed to providing compassionate, comprehensive, timely and high quality service to our patients. Our
clinical faculty receives a large number of referrals for sub-specialty care from community neurologists, other
community specialists, and other clinical department faculty physicians.
Our clinical and research faculty value the role of providing education and support for future physicians and
researchers. We provide our residents, medical students, graduate students and postdoctoral student researchers with
an enriched and supportive professional environment that creates a high-value educational experience. The
Department conducts weekly Neurology Grand Rounds; our program in 2016-2017 featured 34 lectures, 3 of whom
were Visiting Professors from other institutions. We also had 3 Neurology & Neurosurgery Combined Grand
Rounds, 14 Resident Presentations, 9 In-House presentations and 5 presentations from other departments at
UPMC. In addition, multiple conferences and lectures were overseen by our clinical divisions or research centers.
The department also co-sponsors special lectures through PIND, the ADRC and in conjunction with the Department
of Medicine and Neurosurgery.
Clinical research activities benefit our current patients, allow access to cutting-edge therapeutic trials, and provide
significant advances in the overall field of clinical neurology and our clinical research programs have grown
significantly. We develop, maintain, and promote innovative and integrated research programs that promote
fundamental discoveries in basic science areas.
The Department of Neurology faculty and staff are very involved with medically related organizations on the local,
national, and international levels. This involvement extends beyond the medical realm to groups providing support
to patients and caregivers, organizing and supporting fundraising efforts for voluntary health organizations and
raising awareness of neurological diseases. Many of our faculty members and staff have national leadership positions
on NIH advisory or research review committees, in voluntary health organizations, and professional societies.
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Leadership
Lawrence Wechsler, M.D., Chair of the Department of Neurology is professor of Neurology and
Neurological Surgery at the University of Pittsburgh School of Medicine and is former director of the
University of Pittsburgh Medical Center (UPMC) Stroke Institute. He also serves as Vice President
for Telemedicine in the Physician Services Division. Prior to assuming the chair position, Dr.
Wechsler served as Vice Chair for Clinical Affairs and maintained oversight of all clinical operations
within the department. Under his direction the neurology department has continued to expand both
its clinical operations and research activities. Dr. Wechsler’s interests include acute stroke therapy, imaging
and telemedicine. He has participated in many clinical trials of treatments for stroke as an investigator or member
of the steering committee. He was Editor in Chief of the Journal of Neuroimaging from 1999-2007. Dr. Wechsler
holds memberships in several organizations, including the American Neurological Association, American Stroke
Association, American Society of Neuroimaging and the American Academy of Neurology. Dr. Wechsler has
authored or co-authored numerous articles related to stroke and stroke therapy. At UPMC, Dr. Wechsler developed
and implemented the telemedicine program for acute stroke assessment. Beginning in 2006, telemedicine has been
implemented in all UPMC system hospitals to provide access to acute stroke assessment and treatment by faculty of
the UPMC Stroke Institute. Additionally, several other non UPMC facilities are now utilizing telemedicine similarly
for stroke care.
There are 4 vice chairs in the Department of Neurology:
Steven H. Graham, M.D., Ph.D. is Professor of Neurology and Vice Chair for Research. He directs
the operations of the Research Division. Chief among his responsibilities is recruiting world-quality
researchers to an expanding basic science program. Dr. Graham is an accomplished researcher in
neuronal cell death following ischemic injury. He is Associate Chief of Staff for Research for the
Pittsburgh VA Healthcare System and is the Director of the Geriatric Research Educational and
Clinical Center, the major focus of which is cerebrovascular disease.
Paula Clemens, M.D. is Professor of Neurology and Vice Chair for Veterans Affairs. She is Chief
of the Neurology Service at the Pittsburgh VA Healthcare System, responsible for clinical care and
teaching at the VA. She is also an accomplished researcher in clinical and basic studies of treatments
for disorders of skeletal muscle, one of an elite group of researchers who utilize gene therapy in the
experimental treatment of neuromuscular diseases.
Tim Greenamyre, MD, PhD is Professor of Neurology and Vice Chair for Academic Affairs, UPMC
Endowed Chair in Movement Disorders and Director of the Pittsburgh Institute for Neurodegenerative
Diseases. Dr. Greenamyre’s research focuses on the cause of Parkinson’s disease and he is the
Director of an NINDS Program Project Grant entitled “Mitochondrial Proteins in Parkinson’s Disease”
Maxim Hammer, MD is Associate Professor of Neurology and Vice Chair of Clinical Affairs and
Director of Inpatient Services, which involves oversight of inpatient neurological care at many UPMC
hospitals, and Director of Stoke Services at UPMC Mercy Hospital. Dr. Hammer oversees all aspects
of inpatient and outpatient clinical care. His research interests lie predominantly in novel approaches
to acute stroke.
Additional leadership is provided by the Executive Committee: the Department Chair; Vice Chairs; the Division
Chiefs; and Patrick Conway, Department Executive Administrator; Leslie Dunn, Academic Administrator; and Mary
Ann Mirzabeigi, Clinical Administrator.
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Research Activities
The Department of Neurology has a sustained commitment to excellence in the three major components of
academic medicine: teaching, clinical care and research that advances medical knowledge and therapy. Research
funding for clinical, basic, and translational studies in the department has increased steadily over the past few
years and in FY 2017 the department received $14,534,661 in Extramural Research Grant Support and $1,094,550
in Industry Clinical Trial Support.
Basic Research
The Department of Neurology has a strong basic science research program that aims to understand the molecular
mechanisms of neurological diseases and develop new treatment strategies for these disorders. The department’s
basic research program includes the Pittsburgh Institute for Neurodegenerative Disorders, the Alzheimer’s Disease
Research Center and the Geriatric Research Education and Clinical Center. Other areas of focus include
neuromuscular disorders, traumatic brain injury and epilepsy.
Neurology faculty secured funding for a number of new research projects in FY17, including:
• Dr. Edward Burton received funding for a seed grant from the Aging Institute of UPMC Senior Services to
study the pathophysiology underlying age-related neurological diseases such as Parkinson’s disease.
• Dr. Jun Chen received funding for an R01 from NINDS. The project, “Inducible DNA Repair in Cerebral
Ischemia” will test the hypothesis that enhancement of FEN1-dependent DNA repair activity improves long-
term neurological outcomes after cerebral ischemia by promoting the repair process of injured neurons and
white matter.
• Dr. Roberto DiMaio received funding from RIMED Foundation. Selective NOX2 Inhibitor in the Prevention
of Parkinson Disease-Related Neurodegeneration and Movement Disorder to explore and define the role of
NOX2/mitochondria interplay in iPD and models thereof.
• Dr. Steven Graham received funding from the NIH NIHDS for a new R01. The project explores the role
of the neuron specific ubiquitin ligase/hydrolase protein UCHL1 in axonal function and repair in traumatic
brain injury. Novel brain permeable UCHL1 TAT fusion proteins that repair axons will be tested in vitro
and in vivo.
• Dr. Timothy Greenamyre received funding Biogen Pharmaceuticals for Testing Parkinson’s Therapeutics
in Novel Animal Model to study the hypothesis that a brief exposure to a pesticide, like rotenone, such as
one might get occupationally, or even with intensive home gardening, might set off a cascade of pathological
events that could lead – after a prolonged period of neurological normalcy – to development of PD.
• Dr. Timothy Greenamyre received funding from the Blechman Foundation for Clenbuterol Project to
develop proof-of-concept for the prioritized hit, the β2AR-agonist clenbuterol, in a novel progressive model
of endogenous synucleinopathy and Parkinsonism.
• Dr. Timothy Greenamyre received funding for an R21 from NINDS. A Slowly Progressive, Endogenous
Synucleinopathy Model of Parkinson’s Disease to characterize and further develop a novel, progressive
model of Parkinson’s disease.
• Dr. Milos Ikonomovic received funding for an R01 from NIA. Development of a PET Tracer Selective for
Cerebral Amyloid Angiopathy to design, produce, and characterize novel compounds for labeling toxic
deposits of amyloid-beta peptide in brain blood vessels, for use in future imaging studies in living patients.
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• Dr. Emily Rocha received funding from the Parkinson’s Foundation. Loss of Glucocerebrodidase Increase Dopaminergic Neuronal Vulnerability by Impairing Autophagic Flux to test the hypothesize that reduced
GCase activity causes autophagic impairment and is implicated in the pathogenesis of PD. This project will
provide insight into the mechanism that impairs autophagic flux and promotes α-synuclein accumulation in
PD and test the translational potential of GCase.
• Dr. Shanshan Song received funding from American Heart Association, Targeted Knockout of Microgial
Na+/H+ Exchanger-1 in Mice Improves Neurological Function Recovery After Stroke to investigate effects
of selective deletion of microglial Nhe1 in Cx3cr1-CreER;Nhe1f/f mice on neuroinflammation and tissue
repair after ischemic stroke.
• Dr. Dandan Sun received funding from NINDS for a new R01, Liberation of Intracellular Zinc and Neuronal
Cell Death. The project tests the hypothesis that interfering with a cellular process that trigger the Kv2.1-
mediated apoptotic K+ current surge may provide an effective, highly specific therapeutic strategy for
neuroprotection in stroke and related injury.
Clinical Research
Clinical research in the Department of Neurology continues to expand and significant numbers of patients with
neurologic diseases are enrolled in ongoing clinical trials. This is an invaluable resource for continued development
of research in the department, and attracts patients to our medical center. The clinical research program includes
two major research centers: The UPMC Stroke Institute and the NIA-funded Alzheimer’s Disease Research Center
(ADRC). Other areas of clinical research concentration include epilepsy, multiple sclerosis, headache and
neuromuscular disorders.
• Dr. Sara Berman is the site project director for the Dominantly-Inherited Alzheimer’s Network (DIAN)
NIA grant and is the site project director for the first DIAN treatment trial in FY 17. She continued this work
with the Grifols multicenter, randomized, controlled study to evaluate the efficacy and safety of short-term
plasma exchange followed by long-term plasmapheresis with infusion of human albumin combined with
intravenous immunoglobin in patients with mild-moderate Alzheimer’s disease and initiated a new trial with
Lundbeck in patients with mild to moderate AD.
• Drs. Paula Clemens and Larry Wechsler are the Directors of the University of Pittsburgh site in the
NINDS-funded NeuroNEXT, a national clinical trials network established to coordinate Phase 1-2
neuroscience clinical trials and Stroke Net.
• Dr. Paula Clemens is the site project director for the Pompe Study. The purpose of this study is to deterimine
if co-administration of investigational new drugs ATB200 and AT2221 is safe in adults with Pompe disease.
• Dr. Paula Clemens is the site project direct for the AMICUS study, “Open-label, Ascending-Dose, First-in-
Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Intravenous Infusions of ATB200
Alone and ATB200 Co-administered with Oral AT2221 in Adult Subjects with Pompe Disease who were
Previously Treated with Alglucosidase alfa”.
• Dr. Paula Clemens received funding from TRiNDS LLC for a Phase II, Dose Finding Study to Access the
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NS-065/NCNP-01 in Boys with Duchenne
Muscular Dystrophy. University of Pittsburgh is the coordinating center..
• Dr. Islam Zayden is the site P.I. for the Open-Label, multicenter, expanded access program for Ocrelizumab
in patients with primary progress Multiple Sclerosis study. The purpose of this study is to collect safety data
and to monitor the clinical conditional of patients with PPMS who are taking ocrelizumab based on MRI,
EDSS score, or clinical judgment.
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• Dr. Oscar Lopez is the Director of the NIA-funded Alzheimer Disease Research Center (ADRC), which has
been successfully renewed through 2020. He completed a project examining amyloid deposition, vascular
disease and clinical progress of AD. He is also the project leader on a PiB PET imaging Program Project
Grant. In FY 15 he completed a trial (Cytox) comparing the functional integrity of the mTOR pathway with
the PET scan amyloid status (positive or negative) in subjects with a diagnosis of MCI. Several
pharmaceutical trials to improve function in patients with AD are being conducted. New studies have been
initiated in FY 15 with Avid and studies conducted under the NIA-funded Alzheimer’s Disease Cooperative
Study.
• Dr. Oscar Lopez, Co-I, received funding from Cleveland Clinic for a U01. Biomarkers for the Lewy Body
Dementia. This study enrolls subjects that have a baseline evaluation and at least two years of follow up data
and biofluid collection. The study will evaluate motor and behavioral evaluations.
• Dr. Oscar Lopez is the site PI for the ADNI 3 study. This study continues the previously funding ADNA-1,
ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia
and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical
biomarker characteristics of the entire spectrum of Alzheimer’s disease (AD). The overall goal of the study
is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in
AD research.
• Dr. Oscar Lopez and Dr. Beth Snitz received funding for an R01 from NIA. Role of Midlife Cardiovascular
Disease on Alzheimer’s Pathology and Cerebrovascular Reactivity in the Young-Old to further the
understanding of the relationship between AD pathology and neurodegeneration, cerebrovascular reactivity
and midlife CaVD.
• Dr. Ayra Puwanant received funding from MDA. Sub Regional Body Composition and Clinical Endpoint
in Myotonic Dystrophy to test the hypothesis that sub-regional LTM in the preferentially affected muscles
may provide a sensitive endpoint that can be bridged to meaningful clinical outcomes for clinical trials in
DM. The study cohort involves 20 individuals with DM1 and 20 individuals with DM2, and 20 age-matched
healthy individuals.
• Dr. Beth Snitz received funding from NIH for an R01. Alzheimer Neuroimaging-Biomarkers in Pre-Clinical
Cognitive Decline from a Population-Based Study to will investigate in vivo brain imaging of the two
neuropathological hallmarks of Alzheimer Disease (AD) in older adults evidencing pre-clinical cognitive
decline. Appling these imaging tools to a carefully selected and characterized group of recruited participants,
leveraging at least four years of serial, annual cognitive data from a population-based study to define pre-
clinical cognitive decline.
• Dr. Beth Snitz, Co-I, received funding on R01 from NIH. Connectomics of Brain Aging and Dementia to
implement the HCP LifeSpan imaging protocol, and will use the HCP behavioral and cognitive assessments.
• Valerie Suski is the site P.I. for the RESTORE study (a clinical study of patients with symptomatic
neurogenic orthostatic hypotension to assess sustained effects of Droxidopa therapy). The purpose of this
study is to evaluate the time to treatment in patients with PD, MSA, PAF, NDAN, or DBH Deficiency who
have been previously stabilized with droxidopa therapy for symptoms of orthostatic hypotension.
• Lawrence Wechsler is the Director of the University of Pittsburgh NINDS funded Stroke Trials Network as
a Regional Coordinating Center (RCC). The primary goals of the StrokeNet are to maintain a dynamic,
collaborative and sustainable administrative structure to rapidly implement stroke clinical trials, enroll
patients across a wide range of adult and pediatric populations to promote the career development of the next
generation of clinical-investigators in the neurosciences.
• Lawrence Wechsler is the P.I. for the Sanbio Stem Cell Trial study. The SanBio Stem Cell trial is a Double-
Blind, Controlled Phase 2b Study of the Efficacy of Modified Stem Cells (SB623) in Patients with Chronic
Motor Deficit from Ischemic Stroke.
• Dr. Zongqi Xia received funding from NINDS for an R01. Integrating Electronic Health Records and
Genomics to Predict Multiple Sclerosis Drug Response to gain insights into the factors that determine
treatment response and enable physicians to match an individual MS patients clinical and genomic profile
with uniquely tailored therapy to maximize effectiveness, delay disease progression and reduce overall costs.
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Educational Activities
The Adult Neurology Residency Training Program
The Neurology Residency Training Program continues to attract outstanding physicians from the United States and
around the world for state-of-the-art training in the diagnosis and treatment of diseases of the nervous system.
Twenty-eight residents train in the four-year program, which begins with one year of internal medicine residency
and then proceeds for three years of fulltime training in neurology. Resident trainees receive detailed instruction and
practical daily experience in the technique of the neurological examination, localization of abnormalities in the
nervous system, differential diagnosis, and neurological investigation and therapeutics. For a solid underpinning of
basic neuroscience for their clinical training, our residents are taught neuroanatomy, neurophysiology,
neurochemistry, neuroradiology, neuropathology, neuropharmacology as well as retrieval and analysis of current
medical information. There has been an increased emphasis on the fundamentals and application of evidence-based
neurology with special emphasis on the use of online data for decision-making assistance. Under the direction of
an outstanding faculty of attending neurologists, residents assume progressive oversight of patient care during the
course of their training. During the last two years of training, ample elective time allows each resident to develop
skills and expertise tailored to his or her particular interests, while the core curriculum assures a high degree of
competency in general neurology. The residents are given multiple opportunities to teach via formal lectures, small
group conferences and grand rounds presentations, activities which begin to prepare them for careers in academic
neurology, which most pursue. The vast majority of the graduating residents pursue fellowship training.
Neurology Boot Camp: Incoming PGY2 residents are greeted by an innovative and unique method of introducing
trainees to the rapidly growing field of neurology. This experience, termed “Neurology Boot Camp,” immerses our
junior trainees in a month-long fulltime intensive experience fashioned to provide a strong base of knowledge and
understanding upon which the remainder of their experience will build. This introductory course makes use of
extensive case studies, case simulations, an intensive Basic Neurologic Life Support lecture series, a series of
interactive neuroradiology-neuroanatomy correlation sessions, and hands-on rapid medical information retrieval.
Experience in initial training fosters the achievement of a high level of core clinical competency earlier in the course
of training, and lays an even stronger foundation of skills for ongoing lifelong self-education. The program continues
with a renewed emphasis on functional neuroanatomy, localization, and exercises in clinical neuroanatomy mainly
the neurological examination.
Introductory lectures are given in EEG, EMG, and neuroimaging and lectures are also provided about neurologic
emergencies, neurologic tactics.
Dr. John Doyle co-directs the Neurology Residency Program with Dr. Robert Kaniecki and Dr. Ajitesh Ojha is
Assistant Program Director.
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Advanced Neurological Fellowships
Advanced training fellowships in Clinical Neurophysiology, Stroke, Endovascular Neurology and Movement
Disorders are offered through the Department of Neurology. In July 2002, the Stroke fellowship here was one of
the first in the county to receive ACGME approval. Fellows enter these highly competitive positions after
completing a full neurology residency.
Clinical Neurophysiology fellowships emphasize electroencephalography, peripheral neuromuscular physiology,
epilepsy, and neuromuscular disease. Fellows select either an EEG-epilepsy or EMG-neuromuscular track, but have
broader exposure to clinical neurophysiology. There are two funded positions, but the program is accredited for up
to four fellows.
Stroke fellowships provide comprehensive training encompassing the whole spectrum of the rapidly evolving field
of vascular neuroscience. Stroke fellows gain extensive experience with clinical management of complex disorders,
advanced neuroimaging techniques, intravenous and endovascular reperfusion therapies, telestroke, secondary
stroke prevention strategies including endovascular and surgical options for large vessel stroke, advanced diagnostic
and therapeutic options for cardioembolic stroke and evidenced based medical management for stroke prevention.
In addition, fellows are expected to participate in clinical trials addressing all facets of stroke diagnosis and
management. Independent research projects leading to publication in peer review journals are strongly
encouraged. The Stroke fellowship has been expanded to include exposure to interventional and open
neurosurgical given the close integration between the stroke and interventional services. Three ACGME accredited
fellowship positions are offered yearly. Endovascular Neurology: The UPMC neuroendovascular center is one of the highest volume centers in the country.
Fellowship includes training in the whole gammut of neurointerventional procedures such as diagnostic
angiography, stroke intervention, extra and intracranial stenting, aneurysm coiling avm.a-v fistula embolization
and spinal diagnostic angiography and interventions. CAST accreditation is expected to be in place during
2015. Fellows are trained by an interventional team comprised by two vascular neurologists and two vascular
neurosurgeons. The UPMC neuroendovascular fellowship has a strong track record of training neurologists and is
multidisciplinary being fully integrated within neurology and neurosurgery. Considerable experience is obtained
from an extremely active acute stroke service and a busy vascular neurosurgery practice. One fellowship position
is offered yearly.
Movement Disorders Fellowship
Overview
The Movement Disorders Fellowship Program at the University of Pittsburgh brings together resources of the
University of Pittsburgh, Pittsburgh Institute of Neurodegenerative diseases (PIND) and the University of
Pittsburgh Medical Center (UPMC) to provide a unique educational environment with extensive resources
available for clinical and research training in the field of movement disorders. The fellowship program seeks
candidates committed to an academic career in the neurosciences with specialization in Movement disorders.
Consequently, this program emphasizes both clinical and research training in a 1 or 2-year training program.
All fellows will be thoroughly trained in clinical evaluation and management of Movement Disorders. In
addition to developing clinical expertise to become a Movement Disorder Specialist, each fellow will also
participate in one of three individualized research tracks: a Clinical research track, a basic science research track,
or a translational research track which combines elements of clinical and basic science research.
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The description that follows serves only as a guide, as each fellowship will be individualized based on the
applicants interests and goals.
Fellowship Goals and Objectives
1. To be prepared for a career in academic neurology as a movement disorders specialist.
2. To gain clinical expertise in the recognition and treatment of all Movement disorders including Parkinsonian
disorders, Huntington disease, Dystonia, tremor, Tourette Syndrome, chorea, athetosis, tardive
dyskinesia/medication-related movement disorders, ballism, myoclonus, tics, spasticity, rigidity, restless
legs syndrome, gait disorders, ataxia and other movement disorders.
3. To understand the pathophysiology (biochemical, pharmacologic, genetic and physiologic mechanisms) of
movement disorders
4. To learn how to employ pharmacologic, surgical, physiotherapeutic and other treatment approaches to
movement disorders. This includes learning techniques in botulinum toxin injections and programming for
deep brain stimulation.
5. To become familiar with counseling patients and families with movement disorders
6. To acquire skills in clinical, basic science or translational research essential to research methodology of
interest to the applicant. Examples include critical appraisal of relevant literature, clinical rating scales in
the assessment of movement disorders, grant and manuscript writing skills, the conduct of clinical trials,
study design, secondary data analysis or laboratory techniques for a particular project.
7. To develop and present results of clinical, basic science and/or translational research in movement disorders.
This may take the form of a peer-reviewed publication and/or presentation at a scientific meeting.
Fellowship activities
The above goals are accomplished by an experience organized around the following areas:
Clinical Activities
Each fellow will gain expertise in outpatient management of movement disorders under supervision of faculty.
Our faculty represents a diverse range of interests in movement disorders and is committed to teaching fellows.
In addition to outpatient clinics with a wide range of movement disorder patients, specific opportunities exist in
the following fellowship experiences:
a. Comprehensive Movement Disorders Clinic: Every two weeks, all faculty and fellows meet for
movement rounds, which is either a live patient discussion of an interesting case or video rounds. There
is also a clinic in which all movement faculty see patients and a physical therapist is on site to assist in
evaluating and treating movement disorders.
b. Huntington disease Clinic: Once a month, this multidisciplinary clinic serves individuals with
Huntington disease. This includes patient visits with a movement specialist, social worker and genetic
counselor.
c. Dystonia/Botulinum toxin Clinic: Every two weeks, patients with dystonia are evaluated and treated,
many with botulinum toxin injections.
d. Tourette Syndrome Clinic: Once a month, this multidisciplinary clinic at Children’s Hospital evaluates
pediatric movement disorders, primarily tic disorders. This includes an adult movement disorders
specialist, pediatric neurologist and a psychologist.
e. Deep Brain Stimulation: Our clinic is involved in pre-surgical evaluations and postoperative
programming and management of a large number of patients treated surgically with deep brain
stimulation. We work closely with neurosurgery and have bimonthly interdisciplinary meetings with
neurology, neurosurgery, and neurophysiology to discuss cases as well as clinical/scientific aspects of
DBS therapy.
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Research Activities
An individualized program for each fellow will be developed in consultation with faculty in one of three research
tracks:
Clinical research track: Clinical research may include a wide range of topics with any movement disorder
including epidemiology, observational studies, clinical trials, retrospective case reviews, phone surveys,
physiology or other areas of clinical research.
Basic Science research track: Basic science research opportunities exist within any of the wide variety of
laboratories associated with the PIND and the University of Pittsburgh neuroscience community, encompassing
work on in vitro/in vivo disease modeling, pathology, and neurophysiology as well as genetic, molecular,
biochemical, and behavioral aspects of neurodegenerative diseases and other movement disorders
Translational research track: This track emphasizes applying basic science concepts to clinical research.
Examples of translational research include investigations of biomarkers, genetic studies or pilot studies for novel
diagnostic or treatment interventions.
Fellowship Curriculum
Regardless of the track selected, the goal of the Fellowship program is two-fold: (1) To become an expert in
the clinical management of movement disorders, and (2) To successfully develop an area of research expertise.
Fellows are expected to complete at least one research project from conception to publication by the end of
fellowship (typically two years). Because clinical experience informs research activities, fellows will have an
initiation period of the first several months engaged in mostly outpatient movement disorders clinics
(approximately six half-days a week). The remainder of the time during this period is to be used to develop
plans for research. By the end of the initiation period, a project and mentor(s) should be identified, at which
point more time will be reserved for research for the remainder of the fellowship (clinic time may range from
2-5 half-days a week). The duration of the initiation period has an estimated range of 3-6 months. These
numbers are meant to serve only as a guideline to give applicants and idea of what to expect as research and
clinical time will vary based on individual interests, needs and goals.
Learning experiences There are a variety of learning experiences during the course of the Movement disorders fellowship. In addition
to mentorship and faculty supervision during outpatient movement disorder clinics, there are Movement disorder
rounds every two weeks. During these sessions, faculty or fellows present a patient or videos to review with
the faculty from the Movement Division, house staff and medical students. A Movement disorder fellow
organizes these sessions. There is also a movement disorders lecture series given by faculty. Fellows may also
wish to attend grand rounds and review our collection of videos of movement disorders. Each fellow will have
access to a video camera to document movement disorders seen in clinic and then review them with faculty so
that each new patient is discussed in detail. Research methodologies specific to the fellows project will be
reviewed, and a timeline for clinical and research activities will be established at the beginning of fellowship to
ensure goals are accomplished in a timely fashion. Fellows will receive feedback regularly on their progress,
and fellowship program activities will be flexible to cater to individual needs. It is expected that fellows will
attend at least one relevant scientific meeting per year and present their research project at such a venue and/or
in a peer-reviewed publication.
Resources
The University of Pittsburgh, PIND and UPMC provide a rich and unique academic environment for career
development in the neurosciences. The Movement Disorders division is comprised of six faculty, clinical staff
and research associates who specialize in clinical care of movement disorders and have a broad range of
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research interests spanning basic, translational and clinical research. The division also has a digitized movement
disorder video database as a learning and research tool. Additionally, the PIND movement disorder research registry is a rapidly expanding resource of patients who have expressed interest in participating in clinical
research, and have been consented to be contacted for research activities. PIND also has several basic science
opportunities for research and we have ongoing collaborations with the Departments of medicine, psychiatry
and epidemiology at the University of Pittsburgh. Fellows have access to all of these resources during their
Movement disorder fellowship at the University of Pittsburgh.
Headache Medicine - fellowship is a 1-year UCNS accredited fellowship which accepts one applicant each year.
Headache fellows are exposed to the spectrum of headache conditions with intense clinical training under the
supervision of 5 faculty members. Outpatient and inpatient management of headache is emphasized, with additional
training in botulinum toxin injections and pericranial nerve blockade provided. Opportunities exist for elective time
in neuro-otology, neuro-ophthalmology, pain, pediatrics, and head trauma/concussion subspecialties.
Epilepsy - Fellowship provides one year of balanced educational and clinical experience in diagnosing and treating
the most complex forms of epilepsy, including expertise in presurgical evaluation and treatment of the most
challenging cases, along with the use of VNS, RNS and diets. In short, the Program is focused on the training of
academic epileptologists and includes the amount of clinical research that may be escalated commensurate with the
candidates’ aspirations. Currently, the program is undergoing an ACGME accreditation and required structural
changes.
Neurology Medical Student Clerkship
Dr. Laurie Knepper is the director of the University of Pittsburgh School of Medicine Neurology Clerkship and
the Neurology fourth year electives. Sara Carter is the medical student coordinator and administrator. The
Clinical Neurology clerkship is a third-year core clerkship. Students are scheduled per preference in one of six
clinical sites: the inpatient ward service, the inpatient consults service, the VA medical center, Shadyside
Hospital, Children’s Hospital, and neurology outpatient clinics. Students who are on the inpatient service are
also scheduled one half day weekly in the outpatient clinic, as are students who are rotating at Children’s
Hospital.
Each Wednesday students attend a total of nine case-based didactic lectures given by neurology faculty and
residents. These include Neuroradiology, Peripheral Nerve Diseases, Stroke, Movement Disorders, Seizures,
Headache, Multiple Sclerosis, and an NBME subject examination review. Neurology residents have also put
together four neurologic emergency cases which they take turns presenting as one of the student didactics.
Students attend a pediatric Neurology case conference via teleconference at Children’s Hospital at 1pm on
Tuesdays. Students perform an OSCE neurologic exam on a standardized patient at the end of their first week
as a formative exercise; they receive feedback on professionalism and accuracy/ completion of components.
They also attend a two-hour Neuropathology small group session which includes gross sections of brain and
review of neuropathology. Finally, the students take an evening of stroke night call until 11pm with the senior
resident. This enables the students to observe the patient sign-out process and the acute evaluation and
management of stroke patients.
The main educational emphasis of the clerkship is on being able to perform a complete and organized
neurologic examination by the end of their rotation. This is demonstrated by Dr. Knepper at orientation and the
OSCE neurologic exam is at the end of the first week. The students receive a hard copy of a syllabus, which is
also available online on the UPSOM Navigator System. This outlines the clerkship goals and
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objectives and how these are assessed. It also includes information about required forms and conferences, as
well as a list of suggested neurology texts and websites available either online or through the Scaife Health
Science Library. The neurology faculty have also put together a topical syllabus that contains a chapter for each
of the major neurologic disorders, which the students are encouraged to read as they progress through their
rotation. Each student is also loaned a copy of the book Neurology Blueprints.
The students are evaluated in several ways throughout the clerkship. A mid-clerkship evaluation of each student
is done by faculty or a resident and includes feedback as well as student self-reflection on their progress. Faculty
and residents also observe a complete patient history and physical exam for each student and fill out a form
that is signed by students and preceptors. This year there is a redesigned an EMR note review exercise. Each
student is now required to submit one note in the middle of the rotation, for which they receive formative
feedback, and a second note at the end, on which they are graded by one of five reviewers per a standardized
form. Students maintain an online learning log detailing patients they encounter, reviewed weekly by the course
director. The standard UPSOM clinical evaluation form is distributed through Medhub to all faculty, fellows
and residents with whom each student has worked and they submit them as they see fit. This evaluation
encompasses clinical knowledge, clinical skills, data reporting (oral and written, clinical reasoning, problem
solving, and differential diagnosis), professionalism and communication. The students are graded as follows:
clinical evaluations: 50%; the Neurology NBME exam: 25%; the observed patient history and exam: 10%;
EMR note review: 10%, Professionalism: 5%.
Dr. Knepper serves on the Curriculum, Retention, and Promotions Committees. She also leads the Department
of Neurology Medical Education Curriculum Committee.
Future Initiatives
Plans for the Department of Neurology include initiatives in the clinical, research, and teaching areas of our mission.
The department continues to expand with resultant improvement in clinical patient diagnosis and treatment activities.
The department continues to expand the MyUPMC access to include electronic registration and Care Anywhere to
afford patients autonomy and flexibility as active consumers of healthcare services. The department will continue
optimization of the Electronic Health Record (EHR) and review existing workflows to provide further efficiency
and streamlining as faculty and staff has become engaged participants of the upgrades. Additionally, we continue
to improve our self check-in kiosks and biometric screening device workflow to ensure efficiency and patient
satisfaction. The Department will utilize meaningful use data to report quality measures indicative of a fully
integrated EHR. Additionally, the department will work with Press Ganey to obtain and promote patient satisfaction
and best practices amongst all divisions as the department continues to expand to various locations within the
community.
With the expansion of the clinical research, residency, and fellowship programs, the department will focus on
streamlined patient throughput in clinical and administrative space to improve workflow and access to necessary
resources. The project will encompass all clinical and administrative staffing to provide timely and appropriate care
in patient friendly locations utilizing sufficient resources from clinic, multi-disciplines, and community resources.
Neurology’s research program continues to grow. Our researchers have specific plans to increase funding for basic,
clinical and translational research. The department has become one of the top nationwide for NIH research funding
and will strive to achieve more funding. The firm establishment and expansion of the clinical and translational
research programs in neurodegenerative diseases will receive increased attention and resources.
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The education of medical students, residents, and fellows continues to be a high priority. The department will
continue to improve and further develop the didactic programs for neurology residents under the direction of
residency director John Doyle, M.D. Fellowships will be organized and further developed in Vascular Neurology,
Movement Disorders, Neurobehavioral, and Neuromuscular Disease.
The administrative functions of the department are continuously reviewed and improvements made whenever
appropriate. The roles of our Division Chiefs have been expanded to support department administrative efforts. The
Executive Committee consists of the 10 Division Chiefs and the Vice Chairs for Research, Academic, Clinical
Affairs and VA Affairs. The Executive Committee has expanded with the addition of a Director of Inpatient Services
to lead a neurohospitalist division. The Executive Committee will continue to regularly review Department
operations and initiate improvements, modify policy, and advise expansion of clinical, research and teaching
programs as appropriate.
Clinical Activities
The 2015-2016 academic year saw continuing growth in the diagnosis and treatment services of the clinical practice
in the Department of Neurology (University of Pittsburgh Physicians–Neurology). The Department includes the
Divisions of Epilepsy, General Neurology, Headache, Movement Disorders, Neuromuscular Disorders,
Neuroimmunology/Multiple Sclerosis, Cognitive and Behavioral Neurology, and Vascular Neurology The
continued growth of the Alzheimer Disease Research Center in Neurology has expanded services in behavioral
neurology and memory disorders. Each division maintains a distinct mix of patient care, clinical research, and
teaching activities.
Neurology maintains a highly visible presence at several locations throughout Western Pennsylvania. The majority
of clinical activity takes place in the Oakland health system facilities, as well as meeting the needs in other
geographical areas. The Department has a state-of-the-art headache center located in Oakland. The Monroeville-
Oxford Drive, UPMC Shadyside, and UPMC Passavant offices offer general neurology and sleep appointments, as
well as Electromyograms (EMG) in an outpatient setting. UPMC Mercy also offers a full spectrum of outpatient
services including a fully accredited sonography laboratory. The Northshore Neurology practice encompasses a vast
array of outpatient services including general neurology, EEG, EMG, and acupuncture. The department continues
to provide services in St. Margaret’s, McKeesport, West Mifflin and Monaca which provides patient access to
general neurology, EMG and Botox therapy to patients located in these communities. Additionally, the department
also expanded services to Seneca which provides general neurology services as well as telemed patient services for
stroke, movement disorders, and MS.
Faculty members continue to be very active in community programs relating to their subspecialties, such as the MS
Society; National Parkinson’s Foundation; Pittsburgh Parkinson’s Foundation; the ALS Society; the National
Headache Society; Epilepsy Foundation of America; Muscular Dystrophy Association; Myasthenia Gravis
Association; Huntington’s Disease Society of America; and the Alzheimer’s Association. This includes serving on
community or professional advisory boards, and national boards of directors.
Financially, the Neurology clinical practice continues to maintain strong controls over expenditures and consistent
efforts at revenue enhancement including further expansion of clinical practice locations. Clinic operations and
staffing patterns are continuously monitored to ensure optimum return on financial investments. The growing
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presence of physician extenders and multi-disciplinary clinics provides a multitude of services and ensures timely
handling of all areas of care thus increasing efficiency and patient satisfaction. Faculty members are encouraged to optimize their clinic time and to fully and efficiently utilize the time they spend in the clinic. With the optimization
of electronic medical records, faculty is afforded the ability to access records on-demand in clinic and from remote
locations while improving patient care. The patient population continues to grow and clinic accessibility has
expanded to meet the demand. Neurology clinic accessibility has been significantly enhanced with new faculty,
appointment time management, and appropriate utilization of support staff.
Department Clinical Divisions
Division of Cognitive and Behavioral Neurology
Oscar Lopez, MD, Chief of the Cognitive and Behavioral Neurology Division directs the NIA-funded
Alzheimer’s Disease Research Center (ADRC) and is Co-Leader of the ADRC Clinical Core and conducts both
NIH and industry-sponsored experimental therapeutic studies of Alzheimer’s disease. Dr. Lopez’s main area
of concentration is Alzheimer’s disease research, and other related dementias. He led an NIH-funded study
examining predictors of Alzheimer’s disease in mild cognitive impairment (MCI) until April 2013. Dr. Lopez
is currently conducting studies, as principal investigator and co-investigator, of the factors that modulate the
transition from normal to mild cognitive impairment (MCI) and to dementia in relationship to cerebral amyloid
deposition. These studies examine how cardiovascular and cerebrovascular factors create a vulnerability state
for Alzheimer’s disease and neurodegeneration, and how they affect physiologically relevant compensatory
mechanisms in the brain using MRI, FDG-PET, and Pittsburgh Compound B (PiB) and tau ligand technologies.
Dr. Lopez has published, as first author or co-author, 18 peer-reviewed manuscripts between July 2016 and
June 2017. The Division of Cognitive and Behavioral Neurology has a paper published or accepted for
publication every week and a half.
Beth Snitz, PhD is a neuropsychologist with a clinical and research focus on mild cognitive impairment in
aging and early detection and prediction of Alzheimer’s disease. Her research interests also include cognitive
correlates of beta-amyloid, as measured by Pittsburgh Compound B (PiB) – PET and tau deposition, as
measured with [18F]AV1451 PET imaging. Dr. Snitz is involved 6 NIH-funded grants. She has published 9
peer-reviewed articles between July 2016 and June 2017.
She is leading the project entitled ‘Subjective cognitive complaints, longitudinal cognitive decline, and beta-
amyloid deposition in non-demented older adults.’ This research investigated subjective cognitive complaints
as a potential facet of early beta-amyloid-associated, sub-clinical neuronal dysfunction, along with subtle
cognitive deficits and gradual cognitive decline. She was awarded an R01 from the NIA for the project entitled
“Alzheimer Neuroimaging-biomarkers in pre-clinical cognitive decline from a population based study.
Dr. Snitz involved in multiple NIH-funded projects. 1) She is the leader of the Clinical Core of the NIA-funded
program project grant ‘Imaging Pathophysiology in Aging and neurodegeneration (PI: Klunk); 2) she is a co-
investigator on ‘Mild Cognitive Impairment: A prospective community study’ (PI: Ganguli), a population study
of predictors and outcomes of MCI in small-town Southwestern Pennsylvania. 3) She is the
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Clinical Core leader of Alzheimer’s Disease Research Center (PI: Lopez); 4) She is the clinical Core leader of
the Human Connectome Project (PI: Becker). She actively collaborates with colleagues Drs. Ganguli, Klunk,
and Lopez on epidemiologic and clinical studies of cognitive aging, MCI and PiB-PET imaging, including a
longitudinal study of normal aging and beta-amyloid deposition; and a study of cognitive correlates of early
striatal beta-amyloid deposition in early onset familial AD.
In addition to her clinical and research pursuits she is actively involved in Medical Student education at the
University where she is involved in clinical teaching, and mentoring medical students.
Epilepsy Division
During the 2016-2017 academic year, the Epilepsy Division staff included: Anto Bagić, MD, PhD, FACNS
(Professor of Neurology and Neurosurgery, the Division Chief, and Director of the Epilepsy Center, EMU, and
MEG Epilepsy Program), Arun Antony, MD (Assistant Professor Neurology; Director of Continues EEG Service),
Gena Ghearing, MD (Assistant Professor of Neurology; Director, EEG Laboratory and Clinical Neurophysiology
Fellowship; until 12/31/2016), Rick Hendrickson, PhD (Assistant Professor of Neurology, Neuropsychologist;
until 05/01/2017), Jullie W. Pan, MD, PhD (Professor of Neurology), Alexandra Urban, MD (Assistant Professor
of Neurology, Medical Director, Epilepsy Surgery Program; Director of EEG Laboratory and Clinical
Neurophysiology Fellowships since 01/01/2017), and Naoir Zaher, MD (Assistant Professor of Neurology). Maria
Baldwin, MD (Assistant Professor Neurology) and Anne C. Van Cott, MD (Associate Professor of Neurology,
Neurology Service/VA Pittsburgh Healthcare System) are academic members of the Epilepsy Division. Additional
clinical care has been provided by Jill Bischoff, CRNP. Our staff specializes in the comprehensive evaluation and
treatment of patients with all forms of epilepsy including those that are very difficult to diagnose or manage.
In addition to the Department of Neurology, clinical and research activities of the Epilepsy Division take place in
the context of the University of Pittsburgh Comprehensive Epilepsy Center (UPCEC) which is a Level 4
National Association of Epilepsy Centers (NAEC) Epilepsy Center that provides state-of-the-art diagnostic and
treatment services to adults and children with epileptic seizures and related paroxysmal disorders. It is a joint
program combining the resources of the University of Pittsburgh School of Medicine, the University of Pittsburgh
Medical Center (UPMC), Presbyterian University Hospital (PUH) and Children's Hospital of Pittsburgh (CHP).
Established in 1986, among one of the first dozen specialized epilepsy centers in the Country- over the last 30 years
(1986-2016), it has been providing regional referral and consultation services to Pennsylvania, Ohio, West Virginia,
and beyond.
Some Clinical Highlights: Our center remained at the forefront of medical technology, with the most modern digital
video-EEG equipment, latest imaging capabilities (PET, SPECT, MRI, fMRI, and PET-MRI), including a state-of-
the-art magnetoencephalography (MEG) facility, and the EMU equipped with automatic remotely-controlled
SPECT injectors. We improved further by upgrading one more room with new equipment for invasive monitoring.
These advanced diagnostic capabilities, coupled with sustained and comprehensive efforts providing the optimal
care for the hardest-to-treat epilepsy patients with medically uncontrolled seizures, in concert with the Adult
Epilepsy Surgery Program, resulted in a continuation of the large surgical volume and consistently filled the EMU,
continuation of implantation of the RNS Stimulators and adoption of laser ablation in our routine treatment options.
Thus, we remain among one of the leading Epilepsy Centers in the Country.
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Expanding Diagnostic Options for Surgical Candidates: Stereo EEG (SEEG) evaluation is a novel technique
adopted by UPMC in 2013 for localization of seizure onset and analysis of seizure spread. Although a widely-used
method in Europe, only the most capable centers in the United States have the capability of performing this
complicated procedure. SEEG evaluation samples the brain in a 3D space by placing electrodes stereotactically in
the desired locations even when the regions are deep inside the brain. In addition to sampling of the structures deep
inside the brain (i.e. insula, interhemispheric region, orbitofrontal region, operculum, hippocampus) SEEG
evaluation is indicated in patients with multiple seizure foci in both cerebral hemispheres, patients with a network
involvement and those who failed a previous evaluation using subdural grids. After electrode placement in the brain,
cutting edge software allows co-registration of the electrode positions on to the patient’s MRI to pinpoint the location
of abnormal wave forms in all planes of intracranial space. Further analysis of the waveforms during and in between
seizures aims to determine the “epileptogenic zone”, which is the smallest region of the brain that should be resected
to render the patient seizure free. Electrical stimulation of the electrode contacts in the brain is performed to map
cortical functions and to induce seizures for analysis. SEEG evaluation avoids the need for a craniotomy, which is
necessary in a subdural grid evaluation, thereby decreasing pain while offering better aesthetic appeal. Over the last
year, the majority of our patients needing invasive monitoring underwent SEEG as oppose to subdural grid
placement.
Expanding Therapeutic Options for Patients with Pharmacoresistant Epilepsy: The UPMC UPCEC remains
among the top tier of the USA epilepsy centers that offer the full spectrum of all available and evidence-supported
treatment options for drug resistant epilepsy, including Responsive Neurostimulation (RNS) and newly adopted laser
ablation. However, the limiting factor, as it was emphasized in the 2012 IOM Report (“Epilepsy Across the
Spectrum: Promoting Health and Understanding”), is not the availability of treatment options, but the timely referral
for their appropriate consideration without unacceptable delays.
Leading the System-Wide Optimization of Clinical Care: In an attempt to optimize the patient care for epilepsy
patients system-wide, the Epilepsy Service Line was established through the Neurological Institute. The UPCEC
leadership is proposing a new UPMC System-wide Epilepsy Program and suggests the specifics of the organizational
concept and corresponding needs. The key strategic orientation is to improve an access to the specialized care as the
bottleneck of epilepsy care countrywide. While our internal logistics improved considerably over the last five years,
their further optimization is a part of the overall plan for the UPMC System. It is expected that this will lead not
only to standardization but also optimization of care in terms of timeliness, medication choices, utilization of
expertise and resources, and ultimately translate into better outcomes.
In summary, clinical facilities at the center and the expertise of the staff result in definitive diagnoses in patients
with seizures of uncertain origin and medication regimens for optimal seizure control and minimal side-effects.
Patients with medication-resistant seizures can be evaluated for all surgical treatment alternatives including the most
complex surgeries, a Vagal Nerve Stimulator (VNS), RNS implantation and laser ablation. Patients also have access
to neuropsychological evaluations, medication response monitoring, rehabilitation, psychosocial services, referrals
and the possibility of participating in promising clinical drug trials.
Research conducted at the UPCEC had contributed to the introduction of multiple new antiepileptic drugs over the
past decades. Currently, in addition to multiple smaller studies, the major ongoing multicenter trails include: The
ROSE (Radiosurgery vs Lobectomy for Temporal Lobe Epilepsy) Trail (NIH-funded, completed), MONEAD
(Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs) study (NIH-funded), the Established
Status Epilepticus Treatment Trial (ESETT), and “ASCEND: Vagus Nerve Stimulation Titration Protocol to
Improve Tolerance and Accelerate Adaptation” (aka the E-40 Study).
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New Line of Research at UPMC: Since joining the University of Pittsburgh April 2013, the laboratory of Jullie W.
Pan, MD, PhD has focused on studying and identifying the metabolic dysfunction that is commonly seen in
medically intractable epilepsy. As many of their projects are highly translational, they use and develop advanced
imaging methods including MR spectroscopic imaging (MRSI) to achieve this. The group has identified networks
of brain dysfunction in epilepsy and has found that outcomes of localization-related epilepsy (temporal and extra-temporal) patients are significantly related to concordance between MRSI abnormalities with surgical resection.
Currently, as a part of their NIH-supported project (R01 EB-011639), the group is collaborating with NYU (New
York University) to further develop and evaluate the role of MR spectroscopic imaging in surgical epilepsy. The
team remains very active in forging national and international collaborations.
General Neurology Division
Currently, physicians from the Division of General Neurology see outpatients at the Kaufmann Building in Oakland,
UPMC Monroeville, and UPMC Passavant. Members of the division also see inpatients at UPMC Presbyterian,
Magee Woman’s Hospital, and UPMC Passavant. The Division Chief is John Doyle, MD who is also director of
the residency program. Other members of the division are Dr. Angela Lu, Dr. Simin Khavandgar, and Dr. Kelly
Kay.
Dr. Doyle sees general neurology outpatients in the Neurology Division, Kaufmann Clinic where he supervises eight
neurology residents in neurology continuity clinic. Dr. Angela Lu sees out-patients at the Kaufmann Clinic and
provides EMG services at UPMC Passavant. She also provides EEG interpretation services at UPMC Presbyterian.
Dr. Kelly Kay conducts a general neurology clinic and electrodiagnostic (EMG) testing at the
UPMC Monroeville satellite center. Dr. Simin Khavandgar sees general neurology patients and patients with sleep
disorders at UPMC Monroeville, and performs EMG studies at that site.
The General Neurology Division is integral to the training of both medical students and neurology residents. Several
members work closely with medical students during required neurology rotations. Dr. Doyle directs the neurology
continuity clinics for neurology residents, and is assisted by Dr. Angela Lu. During resident training, the neurology
resident must conduct a half-day clinic each week, and follow the patients seen there for the remainder of the training
period. Extensive instruction in clinical neurology, the use of online information retrieval during patient encounters,
neuroimaging, and effective patient management and communication is provided. Resident responsibility
progressively increases during the three-year period of residency. The out-patient clinics prepare residents for
clinical practice at the completion of their training.
Headache Division
Robert Kaniecki MD, Laurie Knepper MD, Barbara Vogler MD, Josif Stakic MD, Claire Yanta MD
Kimberly McGonigle PA-C, Katie Marlin PA-C
Our group continues to provide outpatient clinical services at the Headache Center situated in central Oakland.
Annual clinical volumes at the Headache Center continue to expand to over 12,000 visits per year. In addition to
typical clinical assessments the clinicians provide emergency parenteral therapies, nerve blocks and trigger point
injections, and botulinum toxin administration to appropriate patients with severe or chronic headaches. In addition
to outpatient responsibilities, Drs. Vogler and Yanta spend time on the Neurology Consult service and Drs. Kaniecki
and Knepper on the Neurology Ward service at Presbyterian University Hospital; residents and medical students are
supervised on both services. Dr. Stakic and Dr. Yanta attend at Shadyside Hospital. Lectures
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on headache and pain are delivered by Dr. Kaniecki to the first, second and third-year medical students and to
residents and graduate students in Neurology, Psychiatry, Internal Medicine, Family Practice, Pharmacology, and
Pain Medicine. Drs. Knepper and Stakic also lecture to the medical students. All faculty members supervise resident
and medical student rotations though the Headache Center while all physicians assist in the fellowship training
program.
In 2012 Dr. Kaniecki was named Director of the Headache Fellowship program, and in 2013 Assistant Director of
the Neurology Residency program. Dr. Kaniecki serves as chairman of the Scientific Review Committee, as a
member of the residency selection, residency curriculum, and compensation committees, and the executive
committee for the Department of Neurology. Dr. Kaniecki remains on the editorial board and acts a co-editor of the
Abstracts and Citations section for the journal Headache. In 2012 the Headache Division’s fellowship program in
Headache Medicine was initially accredited by the United Council for Neurological Subspecialties, and in June 2014
received notice of 5-year accreditation status. In 2016 Dr. Kaniecki was again awarded the Excellence in Clinical
Teaching Award in the residency program.
In 2016 Dr. Knepper was named Director of the Neurology Clerkship. She also serves on the Pediatric Neurology
milestone committee, the Promotions committee, the Retention committee, and the Neurology Medical Student
Curriculum committee. She serves as Chair of imaging task force curriculum committee.
She also is a member of the Women in Neurology Core Group.
Dr. Stakic is participating in the Masters in Education program here at the University of Pittsburgh. In 2016 he was
part of a University of Pittsburgh team charged with the development of a neuroscience curriculum for the Republic
of Kazakhstan’s Nazarbayev University newly established School of Medicine
Dr. Yanta was named assistant Director of the Neurology Clerkship in 2016. She continues to expand her capacity
in this role.
Dr. Andrew Levin accepted a position in our fellowship program from the 2017-2018 academic year. He has also
accepted a subsequent faculty position to begin in July 2018.
Dr. Kaniecki continues to conduct clinical research and publish in the field of Headache, and supervises student and
resident research projects resulting in poster presentations at scientific meetings. Drs. Kaniecki, Vogler, Knepper,
Stakic, and Yanta have all received board certification in Headache Medicine from the United Council for
Neurological Subspecialties. The Headache Center is planning to continue the expansion of clinical and research
services and its educational programs for medical students, Neurology residents, and Headache fellows.
Movement Disorders Division
The Movement Disorders Division is directed by J. Timothy Greenamyre, M.D., Ph.D. and includes Drs. Sarah
Berman, Ed Burton, Franca Cambi, Houman Homayoun, Valerie Suski and Amber Van Laar. Additional
clinical services are provided by Jessica Kappel, PA-C. The Movement Disorders Division has three broad
objectives: (i) to provide subspecialty care in Parkinson’s disease and other movement disorders; (ii) provide
education in movement disorders for medical students, graduate students, residents and fellows; and (iii) carry out
research in basic and clinical aspects of movement disorders. The American Parkinson Disease Association (APDA)
has designated the Division as a Center for Advanced Research, one of only 9 such centers in the nation. The
Division currently provides subspecialty care to patients with movement disorders through the Comprehensive
Movement Disorders Clinic, with participation by faculty and staff from the Departments of Physical Medicine and
Rehabilitation, Otolaryngology and Neurological Surgery. Many individuals seen in the clinic also volunteer to
participate in clinical trials of new treatments and in studies supported by the NIH and the VA Healthcare
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System. Clinical programs have grown steadily over the last few years and include the continued expansion of deep
brain stimulation as a treatment for advanced Parkinson disease (in collaboration with the Department of
Neurological Surgery) and a Dystonia/Botulinum Toxin Clinic. The Huntington Disease Clinic continues to grow
and is a Huntington Study Group research site and has been designated by the Huntington’s Disease Society of
America as a Center of Excellence.
During the past year, the Movement Disorders faculty continued to provide bedside and didactic teaching to
undergraduates, medical students and residents. Once a month there is a clinical conference for faculty, residents,
fellows and students at which interesting or difficult-to-diagnose cases are presented. There is a regular lecture
series for residents, and the Movement Disorders lecture series for the first year medical students has been revised
and has received excellent evaluations.
As it expands, the Division continues to have a vigorous and well-funded research program that investigates both
clinical and basic aspects of movement disorders. Each of the faculty has been successful in obtaining extramural
funding for their projects. Several new collaborative projects have begun, which cross traditional boundaries of
scientific discipline and academic department.
Neurocritical Care Division
The Neurocritical Care (NCC) Division of the Department of Neurology was established in July 2012 in a
collaborative effort with the Department of Critical Care Medicine (CCM). The past year has seen further academic
development of our core faculty; growth in NCC related research activities, and expansion of the NCC Fellowship
with the addition of new training opportunities.
The clinical focus of NCC is on the 20 bed Neurovascular and 10 bed Neurotrauma ICU at UPMC Presbyterian
hospital. Unit based, disease specific patient management protocols have been developed to optimize the basic
foundation of clinical care. In addition, a number of unit based, multidisciplinary quality improvement projects with
other members of the NCC team (advanced practice providers, nurses, pharmacists and therapists) have been
completed. These projects included development of a nursing driven fever management algorithm, introduction of
pupillometry, and use of phenobarbital to manage alcohol withdrawal.
Faculty updates include Lori Shutter, MD being selected as a Hedwig van Ameringen Executive Leadership in
Academic Medicine (ELAM) Fellow by the University of Pittsburgh. This program is a year-long part-time
fellowship for women faculty that is dedicated to developing the professional and personal skills required to lead
and manage in today's complex health care environment, with special attention to the unique challenges facing
women in leadership positions. She continues to excel as an educator and was named for the 2nd year in a row as
CCM Faculty of the Year by the critical care fellows in 2016. Her research focus is the area of traumatic brain injury
and advanced monitoring in neurocritical care. Bradley Molyneaux, MD, PhD is an Assistant Professor,
Departments of Neurology, Critical Care Medicine and Neurosurgery. He assists with the fellowship program, is
introducing multiple new clinical management protocols, and establishing his research lab. His research interests
include mechanisms of injury and repair of the cerebral cortex. to identify new mechanisms of neuroprotection and
plasticity after injury. Sherry Chou, MD is an Associate Professor, Critical Care Medicine, Neurology and
eurosurgery. She serves as a clinical research mentor for residents and fellows, collaborates with Neurosurgery on
neuro-monitoring and biomarkers studies in subarachnoid hemorrhage, and is developing the Neurocritical Care
Research Biorepository. Ruchira Jha, MD is an Assistant Professor, Critical Care Medicine, Neurology and
Neurosurgery. She holds a University of Pittsburgh Clinical and Translational Science Institute KL2 career
development award, and collaborates with Neurosurgery and the Safar Center for Resuscitation on research
involving the SUR-1 receptor and brain edema after brain trauma.
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The educational mission of the division continues to expand. The residents are active members of the Neurovascular
ICU during their required rotation, and we have seen increased interest of the neurology residents in NCC
fellowships. The UPMC NCC fellowship has a 5 year accreditation by the United Council of Neurological
Subspecialties (UCNS) and now has 3 accredited tracks for training opportunities within the Multidisciplinary
Critical Care Training Program of the Department of Critical Care Medicine. The tracks consist of the traditional 2-
year training program, a 1 year track for physicians who have obtained critical care training through another medical
specialty, and a 1 year track for Neurosurgery residents who desire specialty training in NCC. Now in its fourth year,
the program has had two graduates, both of whom took academic positions as leaders in development of NCC
programs. Josh Keegan, MD will be starting his second year of fellowship in July 2016, and is following a career
development track in clinical leadership and administration. The 1st year incoming fellow as of July 2016 will be
Namir Khandker, MD, who completed his Neurology residency at Case Western.
Research activities for the Division of NCC focus on efforts to understand the pathophysiology of neurological
injury and clinical management of critically ill neurology patients. There are a number of ongoing clinical trials with
NCC faculty in leadership roles and additional projects are being considered.
In summary, the Division of Neurocritical Care continues to show successful growth in all aspects of the academic,
clinical, educational, and research missions.
Neuroimmunology/Multiple Sclerosis Division
The Neuroimmunology Division includes faculty Drs. Rock Heyman, Islam Zaydan, and Zongqi Xia. Division
physician assistants are Ryan Orie, Jennifer Bajek and Lauren Tankesley. This active division has a
comprehensive outpatient clinical program that has earned awards for its excellence. The MS program is designated
as a Comprehensive MS Care Center by the National MS Society, recognizing comprehensive clinical, research, and
educational programs. Clinical Supervisor Margie O’Leary, Speech Pathologist and Ryan Orie PA-C are board
certified in MS care. Kathleen Brandfass, MS, PT, Director of Neurologic Physical therapy, Center for
Rehabilitation Services is on site with our team. The program includes comprehensive care for all aspects of care
with close affiliations with many services at UPMC and throughout the region to meet the needs of people with MS
at all levels of disease severity. Clinical nurses include Margie O’Leary and Mary Skoff. The infusion center nurses
are Jennifer Victoria Young, Ann Caputo-Dunlap, and Melina Badanich. Many patients with other immunologic
conditions such as neuromyelitis optica (NMO), Sjogren's syndrome or sarcoidosis involving the central nervous
system are seen by this division in support of regional physicians. Ardrena Hill assist with clinical care, Jenna Pyle
provides administrative support for the division.
Division research continues and includes involvement in multi-center studies of oral or infusion therapies for MS
and NMO. Some of the agents used in current protocols are daclizumab, Ibudilast, and ocrelizumab. Other research
projects regarding MS and gastrointestinal dysfunction, MS related ataxia measures, and studies of the genetics of
myelin disorders are underway. The research coordinator, Kerry Oddis, and assistant, Darlene Punjack, provide
organization and support for these trials. Sandra Alhaj manages our Registry for MS and Related Disorders, which
has been supported by the Ethel Vincent Charitable Trust. This registry aids in the recruitment for multiple different
studies. With the addition of Dr. Xia, translational research done in our division and at UPMC and the University of
Pittsburgh is expanding.
Educational programs by division staff are directed towards people with MS, caregivers, allied health professionals,
medical students, residents, and physicians. Medical students and neuroscience students are
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frequently present in the office with our professionals and student nurses off work with our infusion Center nurse
staff. Division personnel frequently lecture to the numerous support groups throughout the region and often
nationally. Recent presentations by divisional professional staff at the CMSC meeting encompassed many areas of
MS care. Division educational conferences occur every Thursday morning. The division also works with regional
health insurance organizations to better organize and access the evolving MS care landscape. We work closely with
the National Multiple Sclerosis Society to provide education and care.
Neuromuscular Diseases Division
The Neuromuscular Division is directed by David Lacomis, MD. Dr. Lacomis and division members, Paula
Clemens, MD, Araya Puwanant MD, and Sasa Zivkovic, MD provide care for neuromuscular patients including
those seen in the affiliated Muscular Dystrophy Association Clinic and MDA-ALS Center (UPMC-Presbyterian
campus). Dr. Clemens also treats patients at the Pittsburgh VA Medical Center in Oakland including a
multidisciplinary clinic for veterans with ALS. Drs. Puwanant and Zivkovic also treat patients at UPMC-Shadyside.
The division trains fellows in clinical neurophysiology and provides electrodiagnostic services (electromyography
and autonomic testing) at UPMC-Presbyterian (Lacomis, Zivkovic, and Puwanant) and UPMC-Shadyside (Zivkovic
and Puwanant). Dr. Puwanant also performs single fiber EMG at UPMC-Presbyterian. Dr. Lacomis performs needle
muscle biopsies and is in charge of the neuromuscular pathology services in the Neuropathology Division. Dr.
Clemens works with trainees through her research program and oversees the neurology residency training program
at the VA Pittsburgh Healthcare System as Neurology Division Chief there.
Dr. Clemens conducts an active research program that includes both basic and clinical studies. Basic research
projects include characterization of the molecular pathology of mouse models of muscle wasting in muscular
dystrophy, muscle injury, idiopathic inflammatory myopathy and nerve injuries, and several methods of modulation
of NF-B signaling pathways for amelioration of the skeletal muscle phenotype in these disorders and modulation
of the immunity. Dr. Clemens is the elected Medical Director of a multi-center academic trials group, the
Cooperative International Neuromuscular Research Group (CINRG) devoted to natural history studies and treatment
trials for Duchenne muscular dystrophy (DMD) and other forms of muscular dystrophy. She chairs 2 multi-center
studies for this group with ongoing funding from the Department of Defense and NIH and she participates as a co-
site PI with Dr. Hoda Abdel-Hamid for other CINRG studies. Dr. Clemens is the chair for a multi-center DMD
treatment trial for a new dissociative steroid that is funded in part by an NIH Small Business Innovations Research
grant as well as other sources. Furthermore, Dr. Clemens is the chair for a multi-center DMD treatment trial for exon
53 skipping therapy, sponsored by NS Pharma, Inc. Dr. Clemens is also contributing Pompe disease patient
information to the Lysosomal Storage Diseases registry at UPMC (Dr. David Finegold, PI) and as a member of the
Pompe Registry Board of Advisors for Sanofi/Genzyme. She is site PI for a recently initiated treatment trial for
adult-onset Pompe patients sponsored by Amicus, Inc. Dr. Clemens is co-director of the University of Pittsburgh
NeuroNEXT clinical study site (funded by NINDS). Dr. Clemens serves on the Data Safety Monitoring Board for a
study sponsored by Pfizer and 2 studies sponsored by the NIH. Dr. Clemens is a steering group member of a group
organized by the Centers for Disease Control to update the Care Considerations for DMD.
Another major area of research involves ALS including participation in multicenter studies of serial biomarkers as
well as DNA banking and gene discovery. Drs. Zivkovic are developing a transcranial magnetic stimulation program
for ALS and using this methodology as part of a multicenter study of mexiletine. Dr. Lacomis provides subjects and
tissues for induced skin pluripotent stem cell research (with Drs. Carlisle, Friedlander, and Donnelly) and also serves
as the Director of Clinical Research in the Live Like Lou Center for ALS Research in the
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University of Pittsburgh Brain Institute directed by Dr. Peter Strick, and he works in close collaboration with Dr.
Christopher Donnelly. The expanding Center is dedicated to all types of ALS research and Neurotechnology
development leading to improved quality of life for patients. An ongoing project is development of an internal
biofluid repository.
Dr. Lacomis is a member of the Adjudication Committee for a study of “Tocilizumab in the Treatment of Refractory
Polymyositis and Dermatomyositis”, directed by Chester Oddis, MD from Rheumatology, and he is also working
on a Scleroderma Myopathy project with Drs. Medsger and Domsic from that division. Last, Dr. Lacomis is a section
co-editor for “What’s in the Literature.” published in the Journal of Clinical Neuromuscular Disease and serves on
its editorial board.
Dr. Zivkovic served as a site-investigator for the International Study of Guillain-Barre syndrome outcomes (IGOS)
and is site-investigator for the study “Expanded Access Protocol for Patisiran” for treatment of transthyretin amyloid
neuropathy. He is a member of IGOS GBS Electrodiagnosis Expertise Group. He is also a member of Brighton
Collaboration working group on immunization-associated events, including vasculitis and vasculitic neuropathy. He
is also working with Dr Soman from Cardiology and Dr Sehgal from Hematology as a part of TTR-Amyloidosis
working group. Dr Zivkovic also serves on AANEM Quality Improvement Committee and AAN. Subspecialty
Quality Advisors Group.
Dr. Puwanant is the Principal Investigator of the study “Sub-regional Body Composition and Clinical Endpoint in
Myotonic Dystrophy”, funded by the Muscular Dystrophy Association (MDA). Dr. Puwanant is the Executive
Committee Member of the NINDS-funded Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)
at the University of Pittsburgh. She is a member of Medical Scientific Advisory Board of the Myasthenia Gravis
Foundation of America. Dr. Puwanant also serves as a reviewer for European Journal of Neurology, European
Neurology, and Journal of the Neurological Sciences.
Research activities for 2017-18 include continued participation in ongoing ALS studies. Drs. Clemens and Abdel-
Hamid continue with muscular dystrophy trials through participation in CINRG, a multi-site academic clinical trials
network. Dr. Clemens takes an active role in CINRG, as Medical Director and study chair for 4 multi-center
protocols. Drs. Zivkovic and Lacomis will be site investigators in a treatment trial of mexiletene for ALS with
monitoring of cortical excitability via transcranial magnetic stimulation (TMS) as well as other outcome measures.
Dr. Lacomis will be the site PI for a new biomarker and deep phenotyping study of ALS using TMS, threshold
tracking, motor unit number estimation, and biofluid collection. The study will assess lower motor neuron burden
and also cognitive function. Dr. Puwanant will be the PI of the new MDA-funded study for myotonic dystrophy.
The study will evaluate sub-regional body composition, measured by DXA estimates, as a novel imaging biomarkers
for disease progression in myotonic dystrophy and the enrollment process will start in the summer of 2017.
Neurooncology Program
The Adult Neurooncology Program is the major regional referral center for patients with central nervous system
tumors, cancer metastatic to the nervous system, and patients with neurologic complications of cancer. Frank
Lieberman, MD (Professor of Neurology, Neurosurgery, and Medical Oncology and Director of the Adult
Neurooncology Program) provides inpatient consultation care for inpatients at the UPMC Shadyside and
Presbyterian campuses. Dr. Jan Drappatz serves as Associate Director of the Adult Neurooncology Program and
is Associate Professor of Neurology and Medical Oncology. The Adult Neurooncology program is committed to
expanding access of brain tumor patients to promising phase I and II clinical trials of novel anticancer agents,
molecularly targeted drug therapies for malignant and low grade gliomas, and primary central nervous system
lymphoma. The faculty of the Neuro-oncology Program provides the neurologic neurooncology expertise for the
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Neuro-oncology Specialty Care Center within the UPMC Hillman Cancer Center on the Shadyside campus. The
SCC is comprised of neurology, neurosurgery, and radiation oncology faculty, all combining to provide coordinated
multispecialty care to patients with primary and metastatic brain, skull base, and spinal tumors. The Neuro-oncology
Program faculty also provide expert consultation and management of non-metastatic neurologic complications of
cancer, including management of seizure disorders, cancer related pain syndromes, neurologic side effects of
chemotherapy and radiation therapy, and paraneoplastic neurologic disorders. Neuro-oncology faculty members
administer chemotherapy for patients with primary brain tumors and oversee and care for patients participating in
clinical trials through the University of Pittsburgh Cancer Institute.
On June 30, 2017, Dr. Megan Mantica, after completing her neurology resident as one of the chief residents in the
Department of Neurology, will be the first neurooncology fellow in our newly approved UCNS Neurooncology
Fellowship program. Dr. Mantica will be participating in patient care both inpatient and outpatient as well as our
translational clinical trial program.
The neuro-oncology program participates in a number of varied studies:
• The translational brain clinical trials program focuses on molecularly targeted drug trials of novel agents for
malignant gliomas. With the reconfiguration of the national cancer clinical trial consortia, Dr. Lieberman has
maintained a leadership role in Adult Brain Tumor Consortium and the NRG Consortium and in the
Experimental Imaging and Biomarker committees of ECOG-ACRIN. Dr. Drappatz is a member of the CNS
Tumor Committee for the Alliance for Clinical Trials in Oncology consortium.
• Through our participation in the ABTC, the Neuro-oncology Program provides patients with access to clinical
trials focused on novel molecularly targeted drugs in phase1 development. The Alliance, ECOG, and NRG
Consortia will be focusing on phase 2 and 3 clinical trials. The range of options for patients therefore spans
novel drugs in early phase development to more mature therapeutics being compared to current standards in
terms of efficacy.
o Our current NCI sponsored clinical trials portfolio includes multicenter trials of molecularly
targeted drugs, novel viral vector based therapeutics, vaccine trials, and immune checkpoint
inhibitor trials. We are participating in an ongoing trial of molecularly targeted drugs for patients
with recurrent or progressive meningiomas with specific mutations.
• We also participate in industry sponsored clinical trials evaluating novel pharmaceuticals, viral vectors
targeting tumor vasculature, and were one of the major US sites for the phase III trial which demonstrated
the efficacy of tumor treating fields for patients with newly diagnosed GBM.
In collaboration with Ajay Naranjan and Dade Lunsford in the Department of Neurosurgery, the Neuro-oncology
Program are conducting an industry sponsored trial evaluating gamma knife radiosurgery combined with
bevacizumab treatment in patients with recurrent glioblastoma. This study is actively accruing patients. The Adult
Neuro-oncology Program is collaborating with other members of the Adult Brain Tumor Consortium to evaluate
novel MRI and PET imaging techniques in assessing treatment response to molecularly targeted therapies, including
the use of 7T MRI to monitor the effects of anti-angiogenic therapies on the vascular anatomy of malignant gliomas.
Dr. Hoby Hetherington, Professor of Radiology, is leading a project imaging tumor metabolites using 7T MRI. In
collaboration with Dr. James Mountz, Dr. Lieberman and colleagues are evaluating a novel PET tracer which
selectively identifies apoptotic cells as a potential tool for determining whether malignant gliomas are responding
to treatment before there is a change in tumor size:
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• Dr. Nduka Amankulor, Assistant Professor of Neurosurgery, is investigating the interactions between
different mutational profiles in glioblastomas and the immune response. Dr. Amankulor is developing models
for elucidating the mechanisms through which IDH1 mutations in human gliomas affect gliomagenesis and
provide targets for molecular therapy.
• In collaboration with Colin Champ, Assistant Professor of Radiation Oncology, we are planning a phase I
clinical trial to address safety and dose-finding for 2-deoxyglucose in conjunction with a restricted ketogenic
diet for patients with newly diagnosed GBM. This is the first step in evaluated this metabolic therapy in
patients with malignant gliomas.
• Dr. Lieberman is currently serving as a member of the Biomarker Committee of the ECOG-ACRIN
consortium, which is tasked with developing the clinical trial infrastructure to evaluate advanced quantitative
imaging technologies to the evaluation of tumor treatment response. From 2012-2013, Dr. Lieberman chaired
the Clinical Trial Design Working Group of the Quantitative Imaging Network, following a year as co-chair
with Brenda Kurland, now a faculty member in the Department of Biostatistics in UPGSPH.
• With the recruitment of Dr. Gary Kohenbash, we are expanding an active immunotherapy clinical trials
program for high and low grade gliomas. Our institution conducted the first vaccine trials for low grade
gliomas. We are participating in the ABTC 16-024 study evaluating anti-LAG3 or CD137 (urelumab) alone
and in combination with nivulomab for patients with recurrent GBM. This is one of the first trials to combine
different classes of immune checkpoint inhibitors for treatment of GBM.
• With the recruitment of Dr. Sameer Agnahotri, we are establishing a laboratory program employing
molecularly engineered animal models of malignant brain tumors to explore the molecular pathways required
for malignant behavior. Dr. Agnahotri is also using these animal models to evaluate potential molecularly
targeted therapeutic drugs to optimize the choice of candidate drugs for human clinical trials.
• Drs. Jonathan Engh and Nduka Amankulor, director and co-director of the neurooncologic neurosurgery
division in the Department of Neurosurgery are collaborating in an UPMC Cancer Center collaboration to
establish tumors, derived from patient tumor tissue removed during surgery, in mice. This project will also
provide test systems for evaluating novel therapeutic agents and also have the potential to personalize
therapeutic testing by matching potential therapeutic agents to a specific patient’s tumor model.
• In collaboration with Dr. Lieberman, Marina Nikoforova and Ronald Hamilton in the Department of
Pathology are using micro-dissection based genetic analysis of brain tumor specimens removed at surgery to
better characterize molecular subgroups of glioblastoma, oligodendroglioma, anaplastic astrocyoma, and low
grade astrocytoma’s with different prognosis and response to therapy. Dr. Nikoforova is applying genome
wide SNIP analysis to paraffin embedded specimens. The molecular neuropathology program at UPMC is
one of the few centers in the world with CLIA certified deep sequencing technology and the neuro-oncology
program is currently participating in the development of a genetic profiling data base in which the genetic
profiling information obtained during clinical diagnostic testing can be used to provide patients with specific
tumor genetic profiles access to clinical trials with molecularly targeted agents aimed at the relevant genetic
abnormalities.
• The development of more effective therapies for patients with skull base and spinal tumors continues to be a
major focus of the Adult Neuro-oncology Program. In collaboration with Neurosurgery faculty Jonathan
Engh, Paul Gardner, and head and neck surgeon Carl Snyderman, Drs. Lieberman and Drappatz and Hussein
Tawbi (Division of Hematology/Oncology) care for patients with complex skull base meningioma’s, and
skull base and spinal chordomas.
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• In collaboration with Paula Sherwood (School of Nursing) the neurooncology program is participating in
studies of caregiver stress in families of brain tumor patients.
• The adult neurooncology faculty collaborate with neuropsychologist Dr. Robert Ferguson, newly recruited
to the Behavioral Oncology Program, in the evaluation of patients with cognitive problems associated with
cancer therapy. Dr. Ferguson is evaluating cognitive rehabilitation strategies for this group of patients
Quality Improvement:
o Neuro-Onc Task Force Initiative: development of hospital system wide multidisciplinary care guidelines to
optimize care of high-grade glioma patients.
Clinical Operations:
o Implementation of the Glio-Pilot project, a clinical pathway for neuro-oncology patients utilizing patient
navigators to improve patient experience and optimize utilization of support services
The Adult Neuro-oncology Program also provides training in neurooncology for neurology residents, neurosurgery
residents, hematology/oncology fellows, and medical students. Residents and fellows attend the neurooncology
clinics at the Hillman Center as well as participate in the neurooncology inpatient consultation service at UPMC
Shadyside. Dr. Lieberman directs a weekly multidisciplinary Neurooncology tumor board which guides the
treatment of complex cases throughout the UPMC Cancer Center network.
The neurooncology program faculty is also involved in continuing medical education at the national level. Dr.
Lieberman serves on the exam committee of the UCNS for neurooncology. This year, Drs. Drappatz and Lieberman
prepared the Neurooncology coursework for the Oakstone Board Review Course in Hematology and Oncology, in
which Hematology Oncology Division faculty are the featured faculty.
Teleneurology (Telemedicine)
Under the direction of Dr. Wechsler, the Department of Neurology began using telemedicine technology in 2008 for
the treatment of stroke patients within the UPMC system. Since that time, the stroke telemedicine network has
expanded to include more than 23 facilities both within and without the UPMC hospital system, and in 2015 has
begun preparations for a stroke telemedicine connection with hospitals in China. In addition, 2014 and 2015 saw
the expansion of this system to include inpatient general neurologic consultations in 2 hospitals.
Our department has been expanding its teleneurology relationships into the outpatient environment. We have
established telestroke clinics whereby Drs. Jovin and Jadhav provide outpatient consultations for potential
neurointerventional cases. In addition, Dr. Valerie Suski, from the Movement Disorders division, and Dr. Islam
Zaydan, from the Neuroimmunology/MS division, provide telemedicine outpatient consultation clinics in their
respective specialties.
Vascular Neurology
The Division is synonymous with the UPMC Stroke Institute and its activities are described under the Stroke Institute
activities.
Women’s Neurology
The Division of Women’s Neurology is directed by Janet Waters, MD, MBA. It is the newest division in the
Department of Neurology and was established in July 2011. This unique interdisciplinary program bridges
neurology with obstetrics, gynecology, obstetrical anesthesia, gynecological oncology, and women’s medicine, and
focuses on gender differences in medical evaluation, diagnosis, and implementation of treatment and care. Its
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specialists consider how hormonal and reproductive changes throughout a woman’s lifespan, including pregnancy
and menopause, as well as the use of oral contraceptives and assisted reproduction, impact neurological health and
disease. In 2015, a number of subspecialists joined the Division of Women’s Neurology while continuing to practice
within the division of their subspecialty. The following physicians have been welcomed into the Division of
Women’s Neurology; Dr. Araya Puwanant, MD of Neuromuscular Disease, Dr. Islam Zayden, MD of Neuro-
Ophthamology and Neuroimmunology, Dr. Robert Kaniecki, MD of the Headache Center, Dr. Valerie Suski, DO,
of Movement Disorders, Dr. Anto Bagic, MD and Dr. Alexandra Urban, MD of the Division of Epilepsy, and Dr.
Tudor Jovin, MD and Dr. Matthew Starr, MD of the Stroke Institute. There are three areas of emphasis: clinical
care, development of research, and patient and physician education. The division offers a clinical program where patients can see physicians specializing in clinical evaluation of the female neurological patient. The Obstetrical
Neurology Clinic offers Neurology services to women with neurologic disease during pregnancy and the post-
partum period and is the only program of its kind in Pennsylvania. Similar services are provided to inpatients on the
obstetrical service at Magee Women’s Hospital. This year, an Epilepsy Monitoring Room was established in the
Obstetrical ICU. Pregnant women with seizure disorders who are admitted to this unit can undergo continuous EEG
and video monitoring while under the close care of the obstetrical team. Inpatient neurologic consultation is also
provided to patients with breast and gynecological cancer with central and peripheral nervous system involvement.
A unique aspect to the division is the clinical and research collaboration with physicians at Magee Women’s Hospital
and the neuro-obstetrical concentration. With over 10,000 deliveries a year, Magee is one of the largest obstetrical
hospitals in the country and houses the extensive Magee Obstetric Medical and Infant (MOMI) research database
with information on more than 100,000 deliveries since 1995. These resources are unlike those anywhere else in
the country and can be used to answer clinical questions regarding women and neurological illness.
In 2016, a study was initiated using the Magee database to determine whether pregnant women with Arnold Chiari
One malformation may safely undergo vaginal delivery.
Due to persistent collaborative efforts through the Women’s Neurology Division, the UPMC became a part of the
two cardinal NIH-funded multicenter observational studies: 1. Women with Epilepsy: Pregnancy Outcomes and
Deliveries (WEPOD that is focused at examining the patterns of fertility among women with epilepsy (WWE)
compared to an age matched group of women without epilepsy (WWoE), and 2. Maternal Outcomes and
Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) that aims to establish the relationship between
antiepileptic drug (AED) exposure and outcomes in the mother and child as well as describe and explain the
variability in AED exposure and response.
Dr. Janet Waters was invited to speak at the American Academy of Neurology Meeting in April of 2016 on the topic
of Neurologic Issues in Pregnancy. She was also a primary editor of the recently published textbook, Neurologic Illness in Pregnancy, Principles and Practice.
In October of 2016, the Division of Women’s Neurology at UPMC will join forces with the Division of Women’s
Neurology at Harvard University to establish the first annual Obstetrical Neurology Conference. Course Directors
will be Janet Waters, MD, MBA and Angela O’Neal, MD, Division Chief of Neurology at the Brigham and
Women’s Hospital in Boston. This will be a multidisciplinary presentation to Neurologists, Obstetricians and Family
Practitioners that will include topics where the fields of Neurology and Obstetrics intersect. Speakers from both
institutions have accepted invitations to present and include members of the Departments of Neurology,
Neurosurgery, Obstetrical Anesthesia, and the Magee Women’s Institute.
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Department Institutes and National Center Affiliations
Alzheimer Disease Research Center (Director: Oscar Lopez)
The ADRC at the University of Pittsburgh, currently directed by Oscar Lopez, MD, was
established in 1985 by a grant from the National Institute on Aging (NIA) and has been
successfully renewed through 2020. The center initially focused on behavioral,
neuropsychological and neuropsychiatric changes over the course of the disease and has
evolved into a broadly based, full-service dementia research center, fulfilling its missions to
conduct clinical, basic, and translational research; provide excellent patient care and follow-up, and educate students,
residents, fellows, faculty, community physicians, and the lay community. Areas of research specialization include
neuroimaging and new neuroimaging modalities, neuropsychiatric symptoms and manifestations in Alzheimer’s
disease and other dementias, neuropathology, genetics, examination of factors that can alter the clinical course of
the disease, and the overlap of Alzheimer’s disease with other neurodegenerative disorders. A wide range of basic
and clinical research studies within the University community are supported by the patient registry, data, biological
materials, or expert consultation from the ADRC. The ADRC has one of the richest databases in the country for the
study of dementia. The ADRC cohort comprises of more than 5,000 patients and the brain bank has more than 650
brains.
The ADRC continues with multiple active research projects and scientific collaborations. During 2016, it has
provided clinical, radiological, genetic, and blood/plasma information to 51 federal- industry-, and foundation-based
grants, and to 28 different principal investigators. In addition, it has conducted 27 national, 12 international, and 11
local collaborative projects. We participate in several national consortia including the Alzheimer’s Disease
Cooperative Study (ADCS), Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Alzheimer’s Disease
Genetics Initiative (ADGI), and the National Alzheimer’s Collaborative Center (NACC) and the Dominantly
Inherited Alzheimer Network (DIAN). It has participated of 11 industry-based trials and projects, and supports two
research studies on African Americans: The influence of African dancing on neurocognitive decline and Novel
multiplexing proteonomics to study the periphery in AD.
Current research studies funded by the ADRC include:
• The identification of amyloid pathology more than 15 years prior to the onset of symptoms in early onset AD
• The examination of the factors that may promote or delay the progression of mild cognitive impairment to
very early AD
• The examination of aging effects on microglia and their role in the early pathology of AD
• Learning new fact knowledge through a basal ganglia reinforcement-learning system
• The exploration of cerebrovascular dynamics in the presence of cerebral amyloid.
• The standardization of synaptic density ligands.
• Head-to-head studies with two tau protein ligands.
• The analysis of synapse loss in AD using a novel Beta Amyloid peptide sensor.
• The genetics of behavioral symptoms in Alzheimer’s disease.
• The standardization of tau ligands for the diagnosis of neurodegenerative disorders.
• The psychiatric impact of disclosing an abnormal amyloid scan to individuals with MCI.
The clinical research component of the ADRC includes an evaluation and treatment program for individuals
experiencing memory impairment. Accurate diagnoses are established through an interdisciplinary approach with
evaluations in neurology, psychiatry, neuropsychology, medicine and social work. After diagnosis, eligible subjects
are followed longitudinally and participate in additional ADRC research studies. Currently, cutting-edge
neuroimaging studies and several experimental therapeutic trials are ongoing in Alzheimer’s disease and related
dementias.
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The PITT ADRC has been taken the necessary steps to ensure robust and unbiased results following strict scientific
methodology since its inception in 1985. Our research plan ensures that each core and project generates high quality,
reproducible, diagnostic evaluations, neuropsychological, and behavioral assessments to ensure robust and unbiased
results when our subjects are included in local, national, and international studies. For example, each participant in
our center is independently examined by a neurologist and a psychiatrist. After the initial examination, the final
diagnosis is reached at a consensus conference where all the neurologists, psychiatrists, neuropsychologists, and
clinicians discussed the clinical, laboratory, and neuroimaging features of each study participant. Because of this
carefully designed process, our diagnostic accuracy has been uniformly high, historically over 93% for AD
diagnosis.
American Parkinson Disease Association Center for Advanced Research
The University of Pittsburgh School of Medicine was designated an American Parkinson
Disease Association Center for Advanced Research in 2006. The APDA is the nation’s largest
grassroots Parkinson’s organization and has been providing patient and caregiver support, free
educational materials and scientific research support for 45 years. As an
Advanced Center, Pitt is part of a network of nine APDA centers at major universities and
healthcare centers across the country. Dr. Tim Greenamyre, the Love Family Professor and Vice-Chair of Neurology,
Chief of the Movement Disorders Division, and Director of the Pittsburgh Institute for Neurodegenerative Diseases,
directs the Pitt APDA Center for Advanced Research.
MDA-ALS Center; Live Like Lou Center for ALS Research
The University of Pittsburgh Center for ALS Research was designated by
Dr. Arthur Levine in 2006 with Robert Bowser, PhD (Pathology) as the
founding director and David Lacomis, MD (Neurology) as the founding
medical director. In 2011 following Dr. Bowser’s departure, Dr. Lacomis
assumed the leadership role in collaboration with colleagues in Neurosurgery (Dr. Robert
Friedlander), Neurology and Neuropathology (Julia Kofler, MD). In 2015, the Center was
incorporated in the newly formed Live Like Lou Center for ALS Research in the University
of Pittsburgh Brain Institute directed by Dr. Peter Strick. Dr. Lacomis serves as the Director
of Clinical Research, and the clinical arm extends to the MDA-ALS Center and
multidisciplinary clinic. The Center recruited a leading ALS researcher (Christopher Donnelly) and we are working
together on developing an institutional biofluid and tissue repository and expanding pluripotent skin stem cell
studies. Long-term goals are to implement clinical trials, spark innovation, and improve quality of life via
neurotechnology. Other ongoing collaborative projects include identification of cerebrospinal fluid and serum
biomarkers and DNA banking. The pluripotent stem cell study will allow examination of human motor neurons and
glia from patients and controls with ALS. In addition, Dr. Kofler maintains a large brain and spinal cord tissue bank
that will be utilized for future investigations. Patients seen in the MDA-ALS Center are able to participate in the
research noted above as well as in a clinical trial of mexiletene and an upcoming trial of a compound that may
ameliorate cramps. They also benefit from seeing multiple experts [including neurologists (Lacomis, Zivkovic,
Puwanant), a nurse practitioner (Rebecca Molczan, CRNP), physical and occupational therapist, dietician, social
worker, swallow and speech therapists, an MDA patient care representative, and an ALSA social worker] in a
multidisciplinary setting.
Geriatric Research Education and Clinical Center
The Geriatric Research Education and Clinical Center (GRECC) is funded by the
Department of Veterans Affairs and provides an integrated program of basic
biomedical, clinical and health services research, education of trainees and
practitioners, and clinical demonstration projects designed to advance knowledge
regarding care of the elderly, with an emphasis on stroke. The research component
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of the GRECC consists of three elements; (1) basic science, (2) health services research, and (3) rehabilitation
research. The basic science component is focused on the identification of novel genes whose products play a role in
regulating cell death after ischemia, and the development of strategies to reduce expression of neurotoxic response
genes or enhance expression of neuroprotective gene products in response to stroke. Health services research is
directed at addressing inappropriate prescribing and the overuse of medications in the elderly VA population
(geriatric polypharmacy). Rehabilitation research includes studies designed to determine the optimal parameters for
rehabilitation of aphasia resulting from stroke, to determine the degree that hearing impairment contributes to
cognitive dysfunction in the elderly, to develop a quality-of-life instrument for stroke survivors, develop innovative cardiac rehabilitation strategies and to address pain assessment and treatment in the elderly. The GRECC faculty
expended over $4.8M in direct costs from federally funded research during the federal Fiscal Year (FY) 2017 in
addition to the GRECC’s $1.9M VA core funding.
The education component of the GRECC is designed to ensure that existing knowledge in geriatrics and new research
findings are integrated into clinical practice and disseminated locally, regionally and nationally, and consists of two
elements; (1) postgraduate fellowship training in geriatrics for physicians, clinical rotations for internal medicine
residents and medical students, and clinical and didactic offerings for trainees in associated
health science fields, and (2) continuing medical education in geriatrics for physicians and other health service
practitioners. There were 141 GRECC trainees (including fellows, residents, medical students, and associated health
trainees) during FY2016 and approximately 929 attendees at GRECC CME activities.
There were fouractive GRECC clinical demonstration projects: 1) The Pittsburgh Intensive Residential Aphasia
Treatment and Educational program (PIRATE) is a novel residential outpatient aphasia rehabilitation program.
PIRATE provides a 21-day program of intensive aphasia treatment for veterans who reside at the John Heinz
Community Living Center in Aspinwal during treatment. 2) The Dementia Telemedicine Clinic that provides
comprehensive geriatric, neurological, psychiatric and social work services for Veterans with dementia including
telehealth services for patients at regional VA Medical Centers and Community Based Outpatient Clinics. These
clinical demonstration projects are intended to pilot novel ways of delivering care to elderly veterans. 3) A new
inpatient and outpatient cardiac rehabilitation (CR) program was developed that employees a large multi-disciplinary
team consisting of a cardiologist, geriatrician, nutritionist, psychologist, social worker, pulmonologist, nurse,
physical therapist, pharmacist, and specialists in sleep, pain management, smoking cessation, diabetes care, yoga,
and tai chi. The CR program stands out as a model of care that can accommodate patients with a range of medical
complexities as well as the logistic challenges associated with living far from the VA campus. 4) A new Geriatric
Polypharmacy E-consult program was developed that consists of a team of a geriatric pharmacist, geriatrician, and
project coordinator to provide e-consults to rural primary care providers at multiple Community Based Outpatient
Clinics (CBOCs) affiliated with the VAPHS for Veterans >65 and taking 10 or more regularly scheduled
prescriptions and non-prescription medications or who were taking any high risk medications.
Dr. Steven Graham, Professor and Vice chair of Neurology, is Director of the GRECC. Other Neurology faculty
members in the GRECC are Jun Chen, MD, Edward Burton MD, J. Timothy Greenamyre MD, Milos
Ikonomovic, MD, Guodong Cao, PhD, Xiaoming Hu, PhD, and Dandan Sun MD, PhD. Faculty from the
Department of Medicine, Divisions of Geriatric Medicine and General Internal Medicine, Neurological Surgery and
Communications Sciences Departments in the School of Rehabilitation Sciences are also members of the GRECC.
Pittsburgh Institute for Neurodegenerative Diseases
It is estimated that approximately one in four Americans will suffer from a
neurodegenerative disease, and virtually all of us will have a family member
with one of these conditions. Unfortunately, the underlying mechanisms of
neurodegeneration – and how they lead to disease – are not well understood.
The complexity of these diseases makes it impossible for any single
28
scientist to find the cause or cure. Instead, it will require an integrated, collaborative, interdisciplinary approach –
involving interactive groups of scientists and clinicians – to make headway towards cures. This was the vision behind
the creation of the Pittsburgh Institute for Neurodegenerative Diseases (PIND).
Ultimately established at the University of Pittsburgh with generous one-time gifts from the Scaife Family
Foundation and the DSF Charitable Foundation, the PIND brings together in one place scientists and clinician-
scientists from diverse disciplines and perspectives – and several School of Medicine departments (Neurology,
Neurobiology, Pharmacology, Pathology & Structural Biology) – to collaborate on studies of neurodegenerative
disorders.
By virtue of both philosophy and architecture, the PIND is a center where there are no walls between individual
scientists, and where there are no barriers between basic scientific inquiry and translation of the latest findings into
new treatments. As such, the mission of the PIND is to transform cutting-edge science into novel therapies and
diagnostics that directly benefit individuals affected by neurodegenerative diseases, such as Parkinson’s disease,
Alzheimer’s disease, stroke, Huntington’s disease, multiple sclerosis (MS) and amyotrophic lateral sclerosis (Lou
Gehrig’s disease). The PIND’s research portfolio spans from basic laboratory studies of molecular and cellular
mechanisms of neurodegeneration all the way to clinical trials, including gene therapy in individuals with
Parkinson’s disease.
The mission of the PIND is bolstered by and integrated with clinical programs in the Department of Neurology,
including the Alzheimer’s Disease Research Center, the Comprehensive Movement Disorders Clinic, the UPMC
Stroke Institute, and the Muscular Dystrophy Association ALS Center. As such, we are actively engaged in clinical
research in neurodegenerative diseases, coordinating or participating in therapeutic trials in Parkinson’s disease,
Alzheimer’s disease, Huntington’s disease, stroke, MS and ALS, and we are a site for trials for both the Parkinson
Study Group and the Huntington Study Group. We have been designated by the American Parkinson Disease
Association as an Advanced Center for Parkinson Disease Research, the only one in the Commonwealth of
Pennsylvania. Additionally, we have been designated as a Center of Excellence by the Huntington’s Disease Society
of America.
Together, the PIND and its associated clinical programs are making sure and steady progress in addressing the
multiple challenges that neurodegenerative diseases present. The PIND is directed by J. Timothy Greenamyre, MD,
PhD.
The UPMC Stroke Institute
The UPMC Stroke Institute was the first stroke center in Western Pennsylvania to receive
The Joint Commission (TJC) designation as a Primary Stroke Center in 2004 and achieved
Comprehensive Stroke Center designation in 2013. The Stroke Institute continues to lead
as a major referral center, provider of high quality acute stroke management, and contributes
to the advancement in the field by participating in and leading enrollment to the most
pertinent clinical research trials for the field. The program focuses on quality patient care
using a multi-disciplinary team approach, flourishing clinical research program, and ongoing educational efforts for
health professionals and the community at large. Tudor Jovin, MD is the Director of the UPMC Stroke Institute.
The Stroke Institute is comprised of a cerebrovascular specific clinical service that provides in person coverage at
three hospitals (UPMC Presbyterian, UPMC Mercy, and UPMC Shadyside) resulting in over 2000 cerebrovascular
inpatients seen annually. In addition, an extensive telestroke network is in place providing remote stroke care at 28
hospital facilities throughout Western Pennsylvania and 1 site in Maryland. The outpatient Stroke clinic is staffed
by the stroke specialists, fellows, and nurse practitioners. Multiple medical and ancillary services are
29
coordinated to provide the patient with a comprehensive approach to care and to promote the best outcome for the
patient. Ashutosh Jadhav serves as the Fellowship Director for the UPMC Stroke Institute, an ACGME
neurovascular fellowship, which accommodates 3 stroke fellows yearly. In addition, an interventional neurology
fellowship is fully integrated within the Stroke Institute. The fellows, residents, medical students and visiting
physicians from abroad enjoy a rich educational experience supported by resources and experts from other
disciplines interested in cerebrovascular disease and research.
Our faculty, Drs. Marcelo Rocha, Ashutosh Jadhav, Matt Starr, Cynthia Kenmuir, Tudor Jovin, Greg Walker, and
Lawrence Wechsler all neurologists with additional training in vascular neurology provide patient care and support
the fellows, residents and medical students during their medical training while actively involved in research either
through participation in multicenter clinical trials or through pursuit of internal research projects. Dr. Jadhav has
assumed leadership of stroke services at the UPMC Mercy and Shadyside campus’ and continues to staff the outpatient stroke office there. Dr. Tudor Jovin and Ashutosh Jadhav continue to expand the scope of the neuro-
interventional practice through the clinical services they provide in addition to research.
Throughout the year the Stroke Institute faculty and staff provide education for health professionals and the
community at large. An annual CME program, Stroke Update, is offered with the goal of providing physicians
(locally and nationally) current information on medical, interventional, and surgical management of the stroke
patient and updates on scientific advances in stroke and clinical trial activity. Additionally, the 10th annual all day
nursing conference with continuing education credits focusing on stroke was provided this year. The Institute
supports community programs and provides stroke education in many local settings. Both faculty and staff are
active on the local, state and national level providing education and participating in legislative activities to promote
stroke care. In addition, Stroke Institute faculty occupy leadership position as Principal Investigators or steering
committee members on several national and international trials pertaining to the field of acute stroke interventions
or recovery. The ongoing commitment to research by Stroke Institute faculty and fellows has materialized into over
15 stroke institute initiated study papers presented at major national or international meetings as well authorship in
over 20 peer-reviewed papers.
The unique UPMC hospital system allows the faculty and staff to work with all UPMC community-based hospitals,
improving the standards of stroke care. Telemedicine equipment for 24/7 stroke assessment has also been introduced
at UPMC Passavant/Passavant-Cranberry, UPMC St. Margaret, UPMC McKeesport, UPMC Magee, UPMC
Horizon, and UPMC Northwest and UPMC Bedford. In 2008, the Institute began to expand services to non-UPMC
affiliated hospitals and now provides telemedicine to regional hospitals such as Monongahela Valley Hospital,
Meritus Hospital in Hagerstown, MD, The Washington Hospital, Washington, PA, Jameson Hospital, and Heritage
Valley Medical Center – Beaver Valley campus, Uniontown Hospital, Armstrong County Memorial Hospital, Excela
health system with Westmoreland, Latrobe, and Frick hospitals, and Mon General Hospital in Morgantown West
Virginia. Since implementation of telemedicine within UPMC, over 3500 urgent stroke consults have been
conducted via telemedicine and over 1300 patients have been treated with IV thrombolytics. Depending on the site
capability, patients are either transferred to UPMC PUH for ongoing specialty stroke care or remain at the local
hospital for post thrombolytic stroke care.
Veterans Administration Neurology Service
The VA Neurology Service is a busy clinical in-patient consult and out-patient service
within the Medical Service Line at the VA Pittsburgh Healthcare System (VAPHS). It
provides out-patient and in-patient services to veterans with dementia, movement
disorders, headache, epilepsy, stroke, multiple sclerosis, neuromuscular disorders, neurological complications of
medical diseases and other neurological conditions. Physicians perform out-patient lumbar punctures for diagnosis
and botulinum toxin injections for the treatment of focal dystonias and there is a TOUCH program for natalizumab
infusions. We provide management of vagal nerve stimulators for the treatment of epilepsy and of deep brain
stimulators for the treatment of movement disorders.
30
The clinical services of VAPHS include out-patient clinics at University Drive and Heinz VAMC facilities, in-
patient consultations at the University Drive and Heinz VAMC facilities and an EEG Laboratory at the University
Drive VAMC facility. The VAPHS is a referral center for VAMC facilities in Erie, Butler, and Altoona, PA and
Clarksburg, WV. We also provide electronic consults as part of an expanding telemedicine program at VAPHS. The
VAPHS EEG Laboratory is accredited by the American Board of Registration of Electroencephalographers and
Evoked Potential Technologists (ABRET).
The VA neurology service is fortunate to have a group of expert sub-specialists from the department of neurology
who work together as VA neurologists. Dr. Edward Burton directs our local movement disorders center, which
participates in the central VA Parkinson's Disease, Research, Education and Clinical Center (PADRECC). Dr.
Burton is a movement disorders specialist in the VA Neurology Service. He was joined in March 2014 by Dr.
Houman Homayoun and in July 2014 by Dr. Franca Cambi. Dr. Islam Zaydan joined the VA neurology service
during 2016 and now leads our clinical program in multiple sclerosis. Dr. Steven Graham is director of the Geriatrics
Research, Education and Clinical Center (GRECC), a VA institute focused on multi-disciplinary aspects of geriatrics
care and research. The VA neurology division participates in the education component of the GRECC as a clinical
training site for geriatric psychiatry fellows throughout the year. We also serve as a training site for the geriatrics
fellowship programs at UPMC and St. Margaret’s Hospitals. Dr. Anne Van Cott directs the VAPHS epilepsy services
and participates in the VA Epilepsy Centers of Excellence. She was joined in July 2015 by epilepsy specialist, Dr.
Maria Baldwin. In addition to out-patient clinical care and EEG interpretation, Dr. Baldwin is focusing on providing
neurology telehealth care through video-facilitated remote access visits and electronic consults. She will also be
providing an ambulatory EEG service. Dr. Paula Clemens leads a multi-disciplinary clinic for ALS patients.
The VA Neurology Service is a principal training site for our neurology residency program. On a rotating basis, two
residents are stationed at the VA to provide in-patient and out-patient care on an academic teaching service attended
by one of our attending neurologists. A third resident position is filled by a senior resident doing an out-patient clinic
rotation. The residents also benefit from the contributions to the didactic training program provided by VA
physicians, especially including instruction in EEG reading by Dr. Anne Van Cott. The VA neurology service further
contributes to the educational mission of the neurology department by serving as a clinical rotation site for medical
students in their third year of training and for acting interns in their fourth year of training. Dr. Van Cott directs the
VA clinical rotation site for medical students on their neurology rotation.
The majority of the neurologists on the VA service are engaged in clinical and basic research in addition to their
clinical and educational endeavors. Several VA neurologists held VA research grants during the year as described
in their individual faculty descriptions.
The VA Neurology Faculty for 2016-2017 was comprised of Dr. Paula Clemens, Chief of Service; and Drs. Maria
Baldwin, Ed Burton, Franca Cambi, Kathy Gardner, Steven Graham, Houman Homayoun, Eric Ogren, Anne Van
Cott and Islam Zaydan.
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32
Research and Scholarly Activities
Cognitive and Behavioral Neurology Division
Oscar Lopez, MD
Professor of Neurology
Chief, Cognitive and Behavioral Neurology
Dr Lopez continues actively involved in research. He is the Director of the University of
Pittsburgh Alzheimer’s Disease Research Center (ADRC); the ADRC was recently funded for
the cycle 2016-2020. In addition, he is the principal investigator of 4 NIH-funded grants, and he
is co-investigator in 7 NIH- and 1 DOD-funded projects.
Dr. Lopez is currently conducting studies, as principal investigator and co-investigator, of the
factors that modulate the transition from normal to mild cognitive impairment (MCI) and to dementia in relationship
to cerebral amyloid deposition. These studies examine how Dr Lopez continues actively involved in research. He
is the Director of the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC); the ADRC was
recently funded for the cycle 2016-2020. In addition, he is the principal investigator of 4 NIH-funded grants,
and he is co-investigator in 8 NIH- and 1 DOD-funded projects.
Dr. Lopez is currently conducting studies, as principal investigator and co-investigator, of the factors that
modulate the transition from normal to mild cognitive impairment (MCI) and to dementia in relationship to
cerebral amyloid deposition. These studies examine how cardiovascular and cerebrovascular factors create a
vulnerability state for AD and neurodegeneration, and how they affect physiologically relevant compensatory
mechanisms in the brain using MRI, FDG-PET, and Pittsburgh Compound B (PiB) and tau ligand technologies.
In collaboration with Dr. Janssen from Harvard University, he is examining the overall function of HDL,
specifically apoAI, ApoJ, and apoE concentrations of HDL with and without apoCIII, in relationship to amyloid
deposition in the brain, and incident dementia. We found that these proteins, rather than being broadly
distributed across the entire population of HDL, define subpopulations of HDL that each comprise a minority
of HDL particles. The central hypothesis of the study is that apolipoproteins form new discoverable HDL
subspecies that contain more value for risk prediction than the present homogenous measures of HDL levels.
In collaboration with Dr Sekikawa from University of Pittsburgh, he is examining the presence of amyloid
deposition in the brain of a Japanese population in the city of Osaka, Japan. This study will examine whether
a population with a different lifestyle from Western populations has different patterns of amyloid deposition.
The findings in the Japanese cohort will be compared to The Mayo Clinic Aging Study and to the Program
Project Grant at the University of Pittsburgh.
Dr. Lopez continues involved in the study of genetics and behavioral manifestations of dementing disorders. He
has been member of the panel assembled by the American Psychiatric Association to provide the guidelines for the
use of antipsychotic medication in patients with dementia [The American Psychiatric Association Practice
Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients with Dementia. American Journal of Psychiatry. 2016 May 1; 173(5): 543-546].
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Beth Snitz, PhD
Assistant Professor of Neurology
Associate Director - Alzheimer Disease Research Center Outreach, Recruitment and
Education Core
Associate Director - Alzheimer Disease Research Center Clinical Core
Dr. Snitz is a neuropsychologist with a clinical and research focus on mild cognitive impairment
in aging and early detection and prediction of Alzheimer’s disease (AD). Her research interests
also include cognitive correlates of beta-amyloid deposition as measured by Pittsburgh
Compound B (PiB) – PET imaging; subjective memory complaints; and epidemiology of
cognitive aging.
This past academic year Dr. Snitz began work on a newly funded R01 grant, ‘ALZHEIMER NEUROIMAGING-
BIOMARKERS IN PRE-CLINICAL COGNITIVE DECLINE FROM A POPULATION-BASED STUDY’. The
project will investigate in vivo brain imaging of the two neuropathological hallmarks of AD in older adults
evidencing subtle cognitive decline, specifically: Pittsburgh Compound-B (PiB)-PET to image amyloid-beta (Aβ)
plaque deposition, and [F-18]AV-1451 to image aggregated tau pathology. The study will investigate the sequence
of pathologic events early in AD and thereby inform prevention strategies regarding the timing of interventions
Dr. Snitz is PI of an Alzheimer Disease Research Center (ADRC) Project investigating subjective memory decline
with neuroimaging, psychological and cognitive assessments. She is Director of the Clinical Core of the NIA-funded
program project grant ‘In Vivo PiB PET Amyloid Imaging: Normals, MCI & Dementia’ (Klunk, PI). She is a clinical
neuropsychologist in the ADRC, and co-investigator on ‘Mild Cognitive Impairment: A prospective community
study’ (Ganguli, PI), a population study of predictors and outcomes of MCI in small-town Southwestern
Pennsylvania. She leads the Clinical Team of the newly funded U01, ‘BRAIN CONNECTOMICS IN AGING’, a
Human Connectome Project grant (Becker, PI). Dr. Snitz collaborates closely with colleagues Drs. Ganguli, Klunk,
Lopez and Becker on epidemiologic, clinical and neuro-imaging studies of cognitive aging, MCI and AD.
Epilepsy Division
Anto Bagić, MD, MSc, PhD
Professor of Neurology and Neurosurgery
Chief, Epilepsy Division
Director, Epilepsy Monitoring Unit (ECU)
Chief Scientific Advisor, MEG research
Director, UPMC MEG Epilepsy Program
Director, University of Pittsburgh Comprehensive Epilepsy Center (UPCEC)
Director, Epilepsy Fellowship
Founding Director, Center for Advanced Brain Magnetic Source Imaging (CABMSI;
2005-2009)
President, American Clinical MEG Society (ACMEGS), 2012 – 2015
Immediate Past President, ACMEGS, 2015
Dr. Bagić conducted an Outpatient Epilepsy Clinic, had major attending responsibilities in the EMU, continued to
solely provide interpretations of MEG-EEG studies of epilepsy patients and maintained a monthly Vagal Nerve
Stimulator (VNS) Clinic. Under his direction, the EMU reached a record number of admissions; the MEG Epilepsy
Program sustained its annual volume of MEG-EEG epilepsy studies, while continued Epilepsy Division team efforts
in concert with Adult Epilepsy Surgery Program and Children’s Hospital of Pittsburgh Pediatric Epilepsy Program
resulted in a Level 4 NAEC designation for both Programs (PUH and CHP). The Adult UPCEC team has been
offering the RNS® System among the leading Level IV epilepsy centers in the Country. During the
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past year, a laser ablation became a treatment option available for the selected patients with epilepsy at UPMC.
Working collaboratively with the PUH leadership, he secured the funding for another expansion of the EMU from
6 to 8 fully-equipped beds that comes with the Hospital support for 4 fully-funded epilepsy fellowship positions
annually. Dr. Bagić’s continued responsibility is to further expand the Epilepsy Program that has already grown to
include six sub-specialized adult epileptologists while continuing to direct and further develop the UPMC MEG
Epilepsy Program. UPMC Neurological Institute Epilepsy Subservice Line is the latest organizational framework
through which the PUH Epilepsy Program headed by Dr. Bagić is taking a lead in organizing, standardizing and
overall improving epilepsy care UPMC-wide.
Nationally, Dr. Bagić continued to be very active within the American Clinical MEG Society (ACMEGS) where he
is a founding member, served on the Board of Directors, as a treasurer, President and now in the role of Immediate
Past President he is working on two national surveys focused on the practice (USA MEG Centers are surveyed) and
use (NAEC Epilepsy Centers are surveyed). He is increasingly active on the Board of the National Association of
Epilepsy Centers where he is taking the lead on various specific projects.
Internationally, Dr. Bagić continues his activities within the International Society for Advancement of Clinical MEG
(ISACM) and the Magnetoencephalography International Consortium for Alzheimer’s Disease (MAGIC-AD). He
is a Chair of the upcoming international Program (“Quo Vadis Clinical MEG Worldwide?”) at the 31st International
Congress of Clinical Neurophysiology (ICCN 2018; May 1-6, 2018, Washington, DC, USA) where the very first
dialogue between the leading MEG societies (Japan, USA and Europe) will take place. During the past academic
year, Dr. Bagić presented on the major international meetings, where he also chaired various sessions, published
several articles in major journals, and has a few related articles in review and several in preparation. Recently, he
spearheaded efforts of the ACMEGS on publishing its second Position Statement (“The Value of
Magnetoencephalography (MEG)/Magnetic Source Imaging (MSI) in Noninvasive Presurgical Mapping of
Eloquent Cortices of Patients Preparing for Surgical Interventions”) in Journal of Clinical Neurophysiology.
Dr. Bagić’s research is focused on applications of MEG in studying epilepsy, language, cognition and brain
plasticity. Dr. Bagić is a co-investigator or consultant on multiple MEG-based studies ongoing at UPMC, including
NIH-funded R01 grants. Additionally, he is a site Principal Investigator on three multicenter clinical studies: The
ROSE (Radiosurgery vs Lobectomy for Temporal Lobe Epilepsy) Trail (NIH-funded), MONEAD (Maternal Outcomes
and Neurodevelopmental Effects of Antiepileptic Drugs) study (NIH-funded), and “ASCEND: Vagus Nerve Stimulation
Titration Protocol to Improve Tolerance and Accelerate Adaptation” (aka the E-40 Study, funded by the
Cyberonics/LivaNova).
Currently, the most active MEG research efforts are on studying dementia, music and brain plasticity. Over the last
few years, in the context of EMU and Surgical Epilepsy Program, research interactions with the Brain Modulation
Laboratory (Department of Neurosurgery, directed by R. Mark Richardson, MD, PhD) intensified, yielded a few
upcoming publications.
During the next year, Dr. Bagić will focus on advancing and/or finalizing some of his ongoing studies, starting new
epilepsy projects that involve connectivity analyses and combining MEG and EEG source localization in studying
intractable epilepsy, accelerating the surgical epilepsy program and expanding the Epilepsy Division. Academically,
Dr. Bagić will continue his teaching roles within the Residency Program, Epilepsy Fellowship, Clinical
Neurophysiology Fellowship, MS1 Neuroscience Course, MS4 Clinical Pharmacology, and Epidemiology Course.
Some of Dr. Bagić’s short-term goals are: ensuring sustained recruitment of fellows for epilepsy fellowship at UPMC
and organizing all Pittsburgh researchers studying any aspect of epilepsy in Pittsburgh Epilepsy Research Special
Interest Group. His clinical efforts during the next year will be centered on optimizing patient flow in the expanded
EMU, fostering the growth of the outpatient epilepsy program, including particular attention to transition and transfer
of epilepsy patients from pediatric to adult epileptologists, starting epilepsy support groups for specific
subpopulations such as patients who have undergone epilepsy surgery and intensifying divisional activities through
the Epilepsy Foundation of America.
One of Dr. Bagić’s standing goals is to engage all physician members of Epilepsy Division in various epilepsy
advocacy activities.
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Puja Aggarwal, MD
Clinical Assistant Professor
Dr. Aggarwal has been a member of the neurology faculty since 2014. She completed her
neurology residency at Ohio State University and a fellowship in Clinical Neurophysiology at
Cornell University New York Presbyterian Hospital. She continues to be an active member of
the American Academy of Neurology and American Epilepsy Society. She continues to evaluate
and treat patients with Epilepsy along with managing Vagus Nerve Stimulators. Dr. Aggarwal
Dr. Aggarwal has been a participant in overseeing fellows through overseeing fellow during the
Continuous EEG rotation.
Arun Antony, MD
Assistant Professor of Neurology
Dr. Antony joined the Epilepsy Division in 2013 after completing two years of subspecialty
fellowship training in Epilepsy, EEG and clinical Neurophysiology at the Cleveland Clinic
(Cleveland, OH). He is board certified in Neurology, Clinical Neurophysiology and Epilepsy.
Dr. Antony helped design the implantation schema templates, streamline work flow and helped
with waveform analysis in the stereo EEG (SEEG) program for seizure localization at UPMC.
Dr. Antony has special interest in treating patients with seizures not responding to medications, spells of unknown
etiology and surgical treatment of epilepsy. In addition to his Outpatient Epilepsy clinic, Dr. Antony has attending
responsibilities in Ambulatory (24-48 hour) EEG review, Continuous EEG monitoring and the Epilepsy monitoring
unit where prolonged EEG monitoring is performed to confirm if a known spell is an epileptic seizure, to diagnose
the type and frequency of seizures and to evaluate for epilepsy surgery.
His research is focused on functional connectivity in epileptogenesis, seizure spread and treatment of epilepsy.
Joanna Fong, MD
Assistant Professor of Neurology
Dr. Fong joined the Department of Neurology in September 2013 and came to us from
Cleveland Clinic where she was a clinical assistant professor in Department of Neurology
in the Epilepsy and Sleep Medicine Division. Dr. Fong received her MD in 2005 from Ohio
State University Medical Center and completed her neurology residency, epilepsy
fellowship, and sleep medicine fellowship at Cleveland Clinic in 2011. Her main focus is
the medical management of patients with epilepsy, non-epileptic behavioral spells, sleep
apnea, insomnia, sleep related movement disorders, and hypersomnia.
Dr. Fong’s activities this year included serving as attending on the continuous video EEG monitoring service
in multiple UPMC hospitals and reading all ambulatory EEG studies from UPMC Presbyterian hospital. She
works with medical students and epilepsy fellows on the epilepsy outpatient clinics. Dr. Fong also presented
multiple didactic lectures to family residents, sleep medicine residents and fellows, and neurology residents
in the past few years.
Dr. Fong has been actively participating in EEG reading at various hospital, including UPMC Shadyside,
Passavant, Presbyterian, Magee, and Mercy hospital. She also reads sleep studies from UPMC Montefiore
and Monroeville sleep lab.
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Gena Ghearing, MD
Assistant Professor of Neurology
Dr. Ghearing has been continuing to work to increase the activity of the adult surgical epilepsy
program which is now averaging approximately one surgery each week. Many of these cases
have been complicated cases which require prolonged extraoperative intracranial EEG
monitoring and cortical stimulation studies. The program is also incorporating subtraction ictal
SPECT, MEG, PET, 3T MRI and functional MRI into the evaluation with the cooperation of
colleagues. We have continued the weekly epilepsy surgery conference. This has allowed the
exchange of information and facilitated advances among those interested in epilepsy who work
in neurology, neuropsychology, neurosurgery, MRI, nuclear medicine, MEG, and other interested groups.
Dr. Ghearing’s activities this year included serving as attending on the Epilepsy Monitoring Unit service, the
Neurology Ward service and the Neurology Consult service, as well as seeing patients in the epilepsy clinic. These
rotations include teaching medical students, neurology residents, clinical neurophysiology fellows, and occasional
medicine, neurosurgery, and psychiatry residents. Dr. Ghearing also presented multiple lectures to neurology
residents on topics related to seizures as well as giving other lectures on epilepsy to other audiences including
medical students, critical care fellows, psychiatry residents, and the neurology and neuropsychiatry departments.
Dr. Ghearing continues to be the director of the EEG lab at Presbyterian Hospital, which includes 6 ambulatory EEG
machines for prolonged outpatient recordings and 12 Video EEG machines, which can be utilized for monitoring in
the ICU. We also perform upper and lower extremity evoked potentials, brainstem auditory evoked responses, and
visual evoked potentials. The video continuous ICU services perform 180-190 of studies each month at Presbyterian
and Montefiore hospitals. In addition, the EEG lab at Presbyterian Hospital continues to be a site for training
neurology residents, clinical neurophysiology fellows, epilepsy fellows, and EEG technicians.
Rick Hendrickson, PhD
Assistant Professor of Neurology
Neuropsychologist, Epilepsy Division
Dr. Hendrickson provided clinical neuropsychological services for the Epilepsy Division. His
cognitive assessments are part of comprehensive pre-surgery evaluations for patients with
epilepsy referred to the Department of Neurosurgery for improved seizure control via surgical
alternatives. He also evaluated patients with difficult to control seizures referred to the Epilepsy
Monitoring Unit for differential diagnosis and treatment planning.
In the last year, Dr. Hendrickson’s research contributed to a paper that he authored on patients
with epilepsy and non-epileptic behavioral seizures. He also co-authored a paper that evaluated the neurocognitive
outcomes of patients shortly after an anterior temporal lobectomy that was recently submitted. In addition, he co-
authored a presentation assessing the utility of simultaneous scalp and intracranial EEG in patients with intractable
seizures.
He continued to provide neuropsychological services for a collaborative study of Neurosurgery and Neurology for
patients with temporal lobe epilepsy. Dr. Hendrickson is a co-investigator on Dr. Popescu’s study of cognitive and
psychological functioning of patients with epilepsy and non-epileptic spells.
For the next year, he plans to analyze a database of psychological and neuropsychological variables for an additional
paper of patients with epilepsy and non-epileptic behavioral seizures. He will again provide neuropsychological
services with his main clinical responsibilities addressing the needs of the Epilepsy Division, primarily performing
inpatient assessments.
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Jullie Pan, PhD
Professor of Neurology
Since joining University of Pittsburgh April 2013, our laboratory has continued to work on
developments and applications of advanced MR imaging for the better understanding of epilepsy.
With the 7T human scanner, we have implemented a highly sensitive transceiver array to provide
homogeneous, high contrast and high resolution imaging. In collaboration with the Cleveland
Clinic, we have established a better than 750um isotropic resolution 3D imaging acquisition, for
which an example from an epilepsy patient is shown below (Figure 1). This increased resolution
and contrast will be examined with our team’s image processing expertise to ascertain the added information
available from the ultra-high field images. We have also advanced our ability to rapidly acquire high resolution
spectroscopic imaging at 3T and 7T, based on rosette strategies with k-space coverage. Currently, high consistency
data at a spatial resolutions of 8x8x10mm (0.64cc) covering a frontal-parietal region 48mm thick can be achieved
at 3T in 6-10min, will allow realistic and accurate whole brain MRSI with conventional imaging durations. Aspects
of this work have been presented at the 2015 International Society for Magnetic Resonance in Medicine Toronto
Canada and 2015 American Epilepsy Society meeting Seattle WA. This work is funded by R01-EB011639 and R01-
NS090417 (PI, JW Pan).
Our group has also made progress with rodent studies of epileptogenesis. With the goal of understanding the
metabolic pathophysiology that arises from prolonged seizures (status epilepticus), we have implemented a modified
Hellier Dudeck chemoconvulsant status model to generate a variable injury condition. This condition is of interest
as human epidemiology studies have found that one of the factors in status epilepticus that can influence the
subsequent development of epilepsy is seizure complexity including duration. In initial work studying
epileptogenesis following a 1.5hr and 3hr status epilepticus period, we have found many changes in several
metabolites including N-acetyl aspartate, glutamine, myo-inositol as well as T2 relaxometry. An example of this
work is also shown below (Figure 2) showing the T2 relaxometric changes and a typical spectrum from the CA3
region of the hippocampus. This work showed a metabolomics perspective on the neuronal and astrocytic changes
in the post-status time period and is currently in press with the Journal of Cerebral Blood Flow and Metabolism
2015. This work is funded by R21-NS083035 (PI, JW Pan).
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Figure 1. Ultra-high field 7T
imaging: MP2RAGE T1
weighted imaging dataset with
750um isotropic resolution from
a patient who has right sided
schizencephaly and intractable
epilepsy.
Note dpi quality of image has
been downsampled for ease of
transfer.
Alexandra Urban, MD
Assistant Professor of Neurology
Program Director for the Epilepsy Fellowship
Director of Clinical Neurophysiology Fellowship
Director of the PUH EEG Laboratory
Alexandra Popescu MD joined the Epilepsy Division in 2009 after completing a clinical
neurophysiology fellowship focused on EEG and Epilepsy at Vanderbilt University in
Nashville, Tennessee. At the conclusion of her fellowship, Dr. Popescu was awarded with the
“Clinical Neurophysiology Fellowship Award” for exceptional skills in clinical neurophysiology.
She was appointed Medical Director of Adult Epilepsy Surgery Program at UPMC in 2013. Dr. Urban also has
coordinated the Responsive Neuro Stimulation (RNS) clinic since 2015. She serves as the Medical Director of the
PUH EEG laboratory – the central EEG Laboratory for the entire UPMC System of 32 hospitals. In this position,
she leads, guides and develops clinical programs and quality studies ensuring that the laboratory meets the latest
standards of care and implements policies and procedures based on latest clinical practice guidelines (CPG).
Dr. Urban was appointed as the Assistant Program Director of the Epilepsy Fellowship in 2016 and Program Director
in January 2017, guiding 2-4 fellows per year.
Recently, Dr. Urban took the lead in the preparing the successful application for ACGME accreditation of the
epilepsy fellow which was approved for four positions annually. The ACGME Epilepsy fellowship application,
includes over 80 pages of Epilepsy fellowship policies and procedures, skills and competencies, milestones,
fellowship structure and evaluations. ACGME accreditation is a very important milestone in keeping the UPMC
Comprehensive Epilepsy Program at the forefront of the field nationally.
Dr. Urban was also elected Program Director for Clinical Neurophysiology Fellowship in January 2017.
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Figure 2. Rodent model of
epilepsy. T2 relaxometry from
hippocampal slice, (A) control
and (B) kainate treated rat. In the
kainate rate, there is increased
T2 in the amygdala, piriform
cortex with a smaller ventricle
reflecting the edematous brain.
(C) MR spectroscopy
measurement (2mm isotropic)
from CA3 region of
hippocampus showing
metabolites as indicated.
Significant changes between
kainate and control rats are
found in N-acetyl aspartate,
glutamine and myo-inositol.
Anne C. Van Cott, MD, FAAN
Neurology Service/ VA Pittsburgh Healthcare System
Associate Professor of Neurology
In the past academic year, Dr. Van Cott has continued her clinical and research work in epilepsy.
Dr. Van Cott continues to collaborate with a University of Pittsburgh colleague on a project
examining traumatic brain injury in veterans. She is the principal investigator at the VA for Dr.
Hetherington’s (Director of the Magnetic Resonance Research Center) NIH funded study to
assess metabolic changes in veterans exposed to blast injury using Multiplexed Multiband 7T
MR technology. She is collaborating with Dr. Amy Wagner on a project examining the genetic
influences on epileptogenesis and bio-susceptibility to Post-Traumatic Epilepsy.
She enjoys caring for veterans with epilepsy. She continues to serve as the director of the EEG laboratory at the VA
Pittsburgh Health Care System which is accredited by the American Board of Electroencephalographic and Evoked
Potential Technologists (ABRET) and has expanded the services provided by the laboratory.
As an Associate Professor of Neurology, she is an active member of the Neurology Department’s Medical Student
Curriculum Committee and works at the education coordinator at the VA. In the Spring of 2017, she was a Faculty
Facilitator for the Integrated Case Studies Course for the School of Medicine and served as a Neuroscience
Facilitator for the School of Medicine. She shares the organizational responsibilities for the University Department’s
Women in Neurology organization. She continues to play an active role in the education of residents, specifically
with regards to electroencephalography interpretation. She enjoys serving as a mentor to several residents and a
PhD candidate.
Dr. Van Cott also is a member in several national organizations. She is an active member of the VA Epilepsy Center
of Excellences (ECoE), serves on the Southeast ECoE Steering Committee and serves as the ECoE Chair of the
Women Veterans with Epilepsy Workgroup. Locally, she serves as a member of the Clinical Systems Improvement
Task Committee at the Pittsburgh VA.
Naoir Zaher, MD
Assistant Professor of Neurology
Dr. Zaher has been a member of the neurology faculty since 09/2015. He completed neurology
residency at Henry ford Hospital and Neurophysiology/epilepsy track fellowship at Vanderbilt
University. He is an attending in the epilepsy monitoring unit, where patients with refractory
epilepsy are admitted for evaluation of seizure focus and potential epilepsy surgery. He also
has an epilepsy clinic in which he evaluates and treats patients with seizures. During the
academic year 2016-2017, Dr. Zaher expanded his clinical work to involve more critical care
EEG monitoring
In addition to his clinical responsibilities, Dr. Zaher is interested in clinical research. He is planning to start a
retrospective study looking at the value of continuous EEG in predicting outcome in patients with intracranial
hemorrhage. He also teaches medical students rotating through epilepsy clinic, and residents and fellows in the
Neurophysiology lab at the University of Pittsburgh.
In the coming year, Dr. Zaher will continue to care for patients with epilepsy and teach medical students, residents
and fellows. He intends to expand his clinical duties by taking the role of the Director of critical care EEG, and
planning to mentor fellows interested in doing critical care EEG track fellowship.
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General Neurology Division
John J. Doyle, MD
Associate Professor of Neurology
Chief, General Neurology Division
Director, Residency Training
Dr. Doyle became Residency Program Director for the Department of Neurology in October,
2006. He has supervised resident recruitment since, and all available positions have been
successfully filled with excellent applicants. He directs the course entitled “An introduction
to clinical neurology” (“boot camp”) each year for PGY-2 residents as they start formal
neurology training. The resident complement for the program has been increased to seven adult neurology residents
per year.
Dr. Doyle was the recipient of the Program Director’s Recognition Award from the American Academy of
Neurology in 2016. The Award was presented at the meeting of the American Academy of Neurology in Vancouver,
Canada.
Dr. Doyle’s chief interests lie in clinical neurology and neurologic education. He sees patients in the outpatient clinic
where most of his clinical sessions include neurology residents who are fulfilling training requirements for continuity
clinics. The goals in the clinic are to foster the clinical application of basic neurologic science, the mastery of clinical
neurology, including the interpretation and judicious use of neurologic diagnostic tests, and to offer effective
treatment where available, Dr. Doyle anticipates that by the time the residents complete their training, they will be
competent to enter practice. At the present time, he supervises seven neurology residents on a weekly basis.
Dr. Doyle instructs neurology residents and residents in other disciplines such as psychiatry and physical medicine,
and medical students on the neurology in-patient consultation service. His commitment is six to eight weeks per
year. On average, more than 60 consultations are seen each week.
Dr. Doyle participates in didactic medical student education; he is co-director of the Neuroscience Course for the
PMS1 Medical Students. He lectures extensively in the course and participates in multiple small group case-based
sessions. He is intimately involved in planning the curriculum for the course.
Dr. Doyle has received three “Neurology Resident Teaching Awards” (2002, 2006, and 2010); the “Preceptor of the
Year Award” from third-year medical students (2010) and a national award for “Excellence in Neurologic
Education” from the American Academy of Neurology (2010). In addition, Dr. Doyle has received the “Program
Director’s Recognition Award” from the American Academy of Neurology (2016).
Dr. Doyle is board certified in Neurology and Electrodiagnostic Medicine.
Neil A. Busis, MD
Clinical Professor of Neurology
Director, Community Neurology
Chief, UPP Department of Neurology – Shadyside
Director, Neurodiagnostic Laboratory – UPMC Shadyside
Dr. Busis provided leadership for the UPP Neurology Service at UPMC Shadyside. He directed
an outpatient and consultation service with other neurologists, two physician assistants, and
internal medicine and family practice resident physicians. The active teaching service also
included third and fourth year medical students. As Director of the
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Neurodiagnostic Laboratory at UPMC Shadyside Dr. Busis worked with administration, staff and other providers to
ensure that high quality outpatient and inpatient EEGs and EMGs were provided in a timely fashion. He coordinated
routine, STAT and continuous EEG reading at UPMC Shadyside with the EEG specialists at UPMC Presbyterian-
Shadyside and coordinated EMG services with physicians from the Department of Physical Medicine &
Rehabilitation. He coordinated general neurology activities at UPMC Shadyside with the UPMC Stroke and Neuro-
Oncology Services.
Dr. Busis was again named among the Top Doctors by Pittsburgh Magazine and in Best Doctors and Top Doctors
nationally. Dr. Busis served on the Board of Directors and the Meeting Management Committee of the American
Academy of Neurology and the Coding Subcommittee of the Medical Economics and Management Committee. He
is the principle investigator of the American Academy of Neurology’s research studies on burnout, career
satisfaction and well-being in U.S. neurologists (four publications so far). He serves on the American Medical
Association’s (AMA) Current Procedural Terminology (CPT) Advisory Committee as the alternate representative
from American Academy of Neurology. He is on the steering committee of the National Academy of Medicine
Action Collaborative on Clinician Well-being and Resilience and is co-lead of its Messaging and Communications
Working Group. He has been deeply involved in neurological practice management issues including coding, billing,
payment, regulation and the move from fee-for-service to value based reimbursement. He had two publications in
Neurology this past academic year.
He lectured on a variety of topics locally, regionally, and nationally including coding, billing, reimbursement, quality
measures and burnout/career satisfaction and well-being. He was an organizer of the UPMC Neurology CME course.
He lectured on neurologist well-being and burnout at the University of Rochester and the Clerkship and Program
Directors Conference: Wellness and Burnout During Training at the American Academy of Neurology Annual
Meeting. He gave several other lectures at the American Academy of Neurology Fall Conference and Annual
Meeting on coding and billing, career choice, well-being and burnout.
Dr. Busis participated in the UPMC Shadyside Total Quality Council, helping to develop and present quality
programs in stroke, EMG, and EEG. A program to reduce venous thromboembolism on neurology inpatient services
has been successfully implemented. A program to assess and reduce neurology resident burnout is being developed.
Kelly Kay, DO
Clinical Assistant Professor of Neurology
Dr. Kay joined the Department of Neurology in 2011. She received her Doctor of Osteopathic
Medicine degree from Lake Erie College of Osteopathic Medicine in 2004 and completed her
residency in neurology at Allegheny General Hospital in Pittsburgh in 2008, followed by a
fellowship in clinical neurophysiology. Dr. Kay practices general neurology and performs
EMG/nerve conduction studies in the Monroeville office. Dr. Kay also rounds on the inpatient
neurology and consultation service on the Oakland campus and enjoys working with the
neurology residents and medical students.
Simin Khavandgar, MD
Clinical Assistant Professor of Neurology
Dr. Khavandgar is primarily focused on outpatient clinical neurology and sleep medicine
practice. She sees patients in the neurology and sleep medicine clinics at UPMC Monroeville
center. She has a special interest in the interface of neurology and sleep medicine, including
diagnosis and treatment of sleep disorders associated with movement disorders such as
Parkinson’s disease, cerebrovascular disorders, and multiple sclerosis as well as other sleep
disorders including narcolepsy, central and obstructive sleep apnea. In addition, she has
42
subspecialty training in clinical neurophysiology and performs diagnostic electromyography for patients with a
range of neuromuscular disorders. Dr. Khavandgar also participates in a range of educational activities including
didactic lectures for medical students and residents, and precepting rotating neurology residents and
neurophysiology fellows. She continues to expand the scope of her educational activities at various levels, especially
as it pertains to sleep neurology. She is also looking forward to participate in clinical research opportunities on sleep
disorders in neurological disorders.
Erek Lam, MD Clinical Assistant Professor of Neurology
Dr. Lam is a general neurologist with subspecialty interest in sleep medication who practices at
UPMC Passavant and sees both inpatients and outpatients. His specialty includes sleep disorders,
specifically narcolepsy, restless legs syndrome, REM sleep behavior disorder, and other
abnormal behaviors during sleep. He has a special interest in sleep disorders in patients with
neurologic disease. Dr. Lam is board certified in neurology and sleep medicine. He interprets
sleep studies at UPMC Passavant. He continues to instruct medical students and is involved in
teaching at the University of Pittsburgh Medical School where he gives annual lectures on sleep
physiology and sleep disorders. He also provides lectures and informational sessions to the North Hills community
and UPMC. He has published several peer reviewed papers pertaining to sleep medicine and neurology previously.
Angela Lu, MD
Clinical Associate Professor of Neurology
Dr. Lu is a general neurologist who focuses on out-patient clinical care. Her practice is at the
primary office in Oakland.
Dr. Lu completed her fellowship training in clinical neurophysiology at the University of
Pittsburgh Medical Center in 2008. She utilizes this expertise in performing EMG studies at
UPMC Passavant, and interpreting EEG studies at multiple UPMC hospitals.
Dr. Lu actively participates in both medical student and resident teaching activities. She
precepts several neurology residents in their weekly out-patient continuity clinics. She also frequently works with
medical students & internal medicine residents in the out-patient clinic setting during their neurology clerkships/
rotations. She lectures to medical students on peripheral neuropathy and leads small group clinical neuroscience
sessions. She also instructs neurology residents and fellows in EEG interpretation.
Eric Ogren, MD
Assistant Professor of Neurology
Dr. Ogren continues to provide inpatient and outpatient neurological services for the Pittsburgh
and Butler Veterans Administration Healthcare Systems. During the week, he sees patients at the
Oakland VA Hospital, the H. John Heinz III Progressive Care Center and the Butler VA Hospital.
He supervises house-staff in the Monday and Tuesday Oakland VA Neurology Clinics. He is
part of the Neurobehavioral program at the H. John Heinz III VA and he’s also a consultant to
the Poly-trauma team for veterans with traumatic brain injury.
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Ajitesh Ojha, MD
Clinical Assistant Professor of Neurology
Assistant Program Director, Neurology Residency Program
During the 2016-2017, Dr. Ojha started his first year as faculty in the Department of
Neurology. He spent most of his time serving as a neurohospitalist and was actively involved
in the neurology consult and general neurology inpatient teams. As a result, he worked
extensively both with neurology residents as well as medical students, psychiatry residents
and medicine residents. A significant portion of his time was spent in clinical education of
both residents and medical students.
He also spent his clinical time at UPMC Passavant, seeing consults there on a regular basis. On his off service
weeks, he performed EMGs at UPMC Shadyside and UPMC Presbyterian, interpreted EEGs at multiple UPMC
hospitals and interpreted autonomic studies at UPMC Presbyterian.
In addition to the time spent on his clinical/educational duties, Dr. Ojha was significantly invested in neurology
resident mentoring and career growth, serving as the Assistant Program Director of Neurology. He was
involved in resident feedback/evaluation meetings, recruitment of future residents during interview season as
well as helping with initiation of quality improvement projects for the residents. His contributions to medical
education also consist of giving lectures to 1st year medical students and serving as a facilitator in their small
group sessions. In terms of research, he completed a project focusing on EMG use in ICU patients with
neuromuscular diseases which is currently under review for publication.
In the upcoming year, he plans to continue his active clinical duties while continuing to play a significant role
in both medical education and resident mentoring. He will be taking a more prominent role in recruitment of
future residents and will be serving as an interviewer while continuing his role as the Assistant Program
Director. On the clinical side, he will also be involved in the general teleneurology initiative that is scheduled
to start near the end of 2017.
Janet Waters, MD
Clinical Assistant Professor of Neurology
Chief, Women’s Neurology Division
Dr. Waters joined the Department of Neurology in July 2010. She completed her medical
training at The George Washington University School of Medicine and her neurology residency
at Mount Sinai Medical Center in New York City. She also earned an MBA at the Nance School
of Business at Cleveland State University. She is board certified in Neurology. Dr. Waters is
Chief of the Division of Women’s Neurology. She sees women with neurologic disease in
pregnancy and in the postpartum period. She also sees women with breast and gynecologic
cancer with neurologic manifestations of their disease. Together with faculty from Harvard University, she directed
the first Obstetrical Neurology Conference in Pittsburgh in October of 2016.
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Headache Division
Robert G. Kaniecki, MD
Assistant Professor of Neurology
Chief, Headache Division
Founder and Director, The Headache Center, University of Pittsburgh
Director, Headache Fellowship
Assistant Director, Neurology Residency Program
During the academic year 2015-2016 Dr. Kaniecki continued his role as Director of the
outpatient Headache Center which he founded in 2000. He remains clinically active in the
evaluation and management of headache patients, personally scheduling 300-400 patients each
month. The Headache Center at the University of Pittsburgh has developed into one of the largest headache programs
in the country with over 13,000 outpatient visits per year. It is staffed by 5 physicians and 2 physician assistants at
a state-of-the-art 3700 square-foot outpatient facility. A Headache fellow is receiving training during the 2017-2018
academic year. The Center continues to provide an assortment of medical options for the management of headache,
as well as interventional procedures of neural blockade and botulinum toxin delivery.
Dr. Kaniecki also oversees inpatient headache management program and continues to recruit for additional faculty
to staff the Headache program. In 2017, for the 7th consecutive year, Dr. Kaniecki was named to the Best Doctors
in Pittsburgh list. In 2016, for the 5th time in 14 years, Dr. Kaniecki received the Excellence in Teaching Award from
the neurology residents.
In addition to his clinical responsibilities, Dr. Kaniecki continues to participate in clinical research. Since 2006 he
has served as chairman of the scientific review committee for the Department of Neurology. He sits on the Editorial
Board for the journal Headache and since 2008 he has served as Abstracts Editor for the journal.
Since 2012 Dr. Kaniecki has served as the Director of the Headache Fellowship Training Program and since 2013
he has acted as Assistant Director of the Neurology Residency program. He serves on the residency selection
committee, the quality improvement committee, the compensation committee, and the executive committee for the
Department of Neurology. Dr. Kaniecki remains active in medical education. He delivers the headache and pain
pharmacology lectures for the first-year medical students and also participates in didactic and clinical education of
second, third, and fourth-year medical students. Lectures in the medicine, pain, and neuropharmacology programs
were also delivered again this academic year. Many residents participate in preceptorships at the Headache Center,
and Dr. Kaniecki is an active teacher on rounds, in lecture, and with journal club venues. Outside the University of
Pittsburgh system Dr. Kaniecki remains active in continuing medical education, delivering multiple invited CME
presentations during the 2016-2017 academic year. He acted as a key contributor to recent editions of the MKSAP-17 (Internal Medicine) and Continuum (Neurology) continuing education programs and in 2017 is completing work
on MKSAP-18.
During the upcoming academic year Dr. Kaniecki expects to continue his active clinical duties and participation in
medical educational programs. He intends to expand the educational opportunities in headache for the neurology
residents at the University of Pittsburgh. Plans for participation in a major multi-center clinical trial are also in
progress, and he will continue to participate in single institutional clinical studies involving the diagnosis and
treatment of patients with headache. He mentored medical student, neurology resident, and headache fellow research
projects which generated poster presentations at national scientific meetings.
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Kathy Gardner, MD
Assistant Professor of Neurology
Dr. Gardner's research is focused on the genetics of both common and rare hemiplegic forms of
migraine. She has an ongoing cohort of migraine families and hemiplegic migraineurs for
linkage and mutation analysis. Dr. Gardner also has a study ongoing at the Children’s Hospital
NF clinic to characterize headache types and frequency in subjects of all ages with NF-1 titled
“Headaches in Neurofibromatosis-1.” She is an advisor and board member for the local chapter
of the Neurofibromatosis Clinics Association and is Co-Director of the Children’s Hospital
Neurofibromatosis Clinic.
Laurie Knepper, MD
Associate Professor of Neurology
For the past 1 ½ year I have been the 3rd year Neurology Clerkship Director. We have made
many updates and revisions to our clerkship. Most importantly our end of the year evaluations,
this year note that 94% of students felt the clerkship was well organized and that they received
clear learning objectives. 90% reported that we met those goals. 90% of students rated the
overall quality of the clerkship outstanding and 92% noted that it provided an adequate
experience in Neurology. 85 - 88% felt that overall teaching was of good quality.
Students still feel they need feedback. A continued emphasis was placed on case based didactics – many attendings
and fellows took time to provide this for the 3-hour weekly student didactic sessions. Review of these case based
didactics have been excellent. This year 4 residents revised Neurology emergency cases and different residents gave
this didactic session each month. It was well received by the students. I continue to do the end of rotation NBME
board exam review with an average of 4.7/5 on my student evaluations. I also moderate, with the students via
teleconference, the pediatric neurology weekly case conference. This year our students continued to four points
above the national neurology NBME exam score. This past year, fourth year medical students matched in adult
neurology residency programs including: Mayo Clinic, University of Michigan, Mt Sinai and MGH/Brigham
Women’s. 3 students also chose pediatric neurology for their residencies. I wrote letters of recommendation for
three of these students and advised them before and during the application and interview process. This year Dr.
Kenmuir codirected and ran the four-week Stroke mini elective, it again received 4.8 /5 evaluation scores. It filled
within minutes of the course opening online for these first year UPSOM students. I presented the Neurology
Clerkship Entrustable Professional Activities Student Project at the AAMC Learn Serve and Lead conference,
November 2016. This project enabled us to address the skills our students felt they were not
learning well during their neurology Clerkship. We are now in our second year of addressing and assessing four of
the Entrustable activities with a graded EMR note review with written feedback to each student mid clerkship and
after clerkship completion. Last year, Dr. Claire Yanta and Dr. Andrew Levin assisted with this time intensive
project. This next year Dr. Stakic and Dr. Ohja are joining the note review group. We have recorded one of our
neuroanatomy online modules on the UPSOM Navigator site – Dr. Wilson Heredia designed this and recorded this.
We have been working on 2 more neuroanatomy review modules and pediatric neurology modules, these will soon
be recorded. I also teach small groups in the first-year neuroscience course, the advanced physical exam course and
4 morning sessions in the second-year Integrated Case Studies course. I have already met with students interested
in applying for neurology residency this up coming year.
I also continue to precept 2 residents in clinic and I am a resident mentor for one resident each year. I moderated
morning report every 4-6 weeks this past year.
46
As a core member of the WIN neurology group, I have organized the annual new resident/fellow/faculty neurology
picnic in July and help to organize several yearly informal events. Clinical duties are unchanged. I see patients in
the outpatient headache center six half days each week. I rotate on the inpatient ward, eight weeks each year. I
enjoy teaching both residents and medical students during these times.
Josif Stakic, MD
Assistant Professor of Neurology
Dr. Stakic has been a member of the neurology faculty since 2012. He completed a headache
fellowship training at University of Pittsburgh in 2012. Currently Dr. Stakic sees patients at the
department of neurology headache center where he uses medications, natural measure strategies
and innovative injectable therapies in managing episodic and chronic headache patients. His
inpatient responsibilities included 8 weeks of service seeing general neurology patients at
Shadyside campus. Dr. Stakic enrolled in the masters program in medical education offered by
University of Pittsburgh Institute for Clinical Research Education in 2015. In 2015-2016 academic year Dr. Stakic
participated in the neuroscience curriculum mentoring project through University of Pittsburgh School of Medicine
and Nazarbayev University School of Medicine. In the following academic year Dr. Stakic will continue to care for
headache and neurology patients in the headache clinic and inpatient setting. He will continue to take classes working
towards the completion of the masters program. In addition, he plans to assist in running the first year neuroscience
course at University of Pittsburgh School of Medicine. He will continue his involvement in medical student and
resident education through didactic lectures and clinical precepting.
Barbara Vogler, MD
Clinical Assistant Professor of Neurology
Dr. Vogler joined the Department of Neurology at the UPP Headache Center in August 2006.
Since that time, she has worked with numerous University of Pittsburgh medical students and
neurology residents both in the outpatient and inpatient setting.
In addition to her clinical responsibilities, Dr. Vogler is director of the clinical research section
of the Headache Center.
Claire Yanta
Clinical Instructor of Neurology
During the 2016-2017 academic year, Dr. Yanta continued to evaluate and treat patients in the
Headache Center and acted as attending physician for the neurology consult services at both the
Presbyterian and Shadyside campuses. She also acted as a supervising physician in the outpatient
resident clinic and on the inpatient consult service on the Presbyterian campus. In addition, she
continued in her role as course director for the neurology component of the Advanced Physical
Examination course for the medical students and delivered a cognitive neurology lecture in the
neuroscience course. She also continued in her role as assistant clerkship director for the UPSOM-MSIII/IV
neurology rotation.
In the coming year, she is looking forward beginning her first year as a dual faculty member for both UPMC and
UPSOM. She will continue to act as a supervising physician in outpatient resident clinic as well as on the inpatient
neurology consult service. She will continue in her position as course instructor for the neurology component of the
APE course and as assistant clerkship director for the neurology clerkship. She will also be continuing her role as a
FAST advisor to the medical students.
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Movement Disorders Division
J. Timothy Greenamyre, MD, PhD
Love Family Professor and Vice-Chair for Academic Affairs
Chief, Movement Disorders Division
Director, Pittsburgh Institute for Neurodegenerative Diseases
Scientific Director, University of Pittsburgh Tsinghua University Scholars Program
Dr. Greenamyre is Chief of the Movement Disorders Division, Love Family Professor and
Vice-Chair of Neurology. Dr. Greenamyre established the Comprehensive Movement
Disorders Clinic, which serves as the focal point for clinical care, research and teaching of
disorders, such as Parkinson’s disease, Huntington’s disease, tremor and dystonia. The
Movement Disorders Division consists of 7 clinician-investigators, a nurse, a medical assistant and 2 clinical
coordinators. Dr. Greenamyre maintains an active clinical practice and is an investigator in several clinical studies.
Since 2009, Dr. Greenamyre has been named as one of America’s Top Physicians and as one of the Best Doctors in
America. In 2015, Dr. Greenamyre was inducted into the Association of American Physicians, an honor extended to
individuals with outstanding credentials in biomedical science and/or translational biomedical research.
Dr. Greenamyre is Director of the Pittsburgh Institute for Neurodegenerative Diseases (PIND), an interdepartmental,
interdisciplinary institute that occupies the 7th floor of the new Biomedical Science Tower 3. The PIND consists of
approximately 100 faculty, postdocs, students and staff in an open-lab, collaborative environment – and is dedicated
to the study of neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s diseases, as well as
ALS, MS and other related disorders. In the PIND, there is an emphasis on defining disease mechanisms with the
ultimate goal of developing new diagnostic and therapeutic modalities.
In terms of teaching, Dr. Greenamyre serves on several PhD thesis committees and as the primary mentor on K-
awards for junior faculty, and he is the supervisor of several postdoctoral research fellows. He has mentored 25
postdoctoral fellows and his previous trainees have been very successful. Most have remained in academia, where
they range from Full Tenured Professor (and Residency Director) to Assistant Professor, tenure track. Other trainees
have gone into industry (Roche, Merck, Organon, and Shire) or taken ‘non-traditional’ positions, including CEO of
the Michael J. Fox Foundation. He has also mentored 3 MD-PhD students.
Dr. Greenamyre is engaged in both clinical and basic laboratory research. His work is funded by NINDS, NIEHS,
the American Parkinson Disease Association, the Parkinson’s Disease Foundation and the Michael J. Fox
Foundation. He is an investigator in the Huntington Study Group and the Parkinson Study Group. His laboratory
investigates basic mechanisms of neurodegeneration. He is a member of the Scientific Advisory Board of the
Michael J. Fox Foundation and the Parkinson’s Disease Foundation and the Advisory Board of the Neurological
Institute “C. Mondino” in Pavia, Italy. He is Editor-in-Chief of Neurobiology of Disease and MedLink Neurology
and a member of the editorial boards of several other scientific journals, including the Journal of Clinical Investigation.
Sarah B. Berman, MD, PhD
Assistant Professor of Neurology
Dr. Berman has been a member of the neurology faculty since 2005, after completing neurology
residency and fellowship training at the Johns Hopkins University. She continues to be an
active member of the Movement Disorders Division and treats patients with Parkinson’s
disease and other movement disorders as part of the Comprehensive Movement Disorders
Clinic. In addition, she continues to evaluate and manage patients with deep brain stimulators
(DBS) implanted for Parkinson’s disease, tremor, and dystonia.
48
She oversees management and programming of stimulators, other aspects of treatment, and evaluations and referrals
for new patient candidates. Since 2008, she also evaluates patients at the Alzheimer’s Disease Research Center.
Dr. Berman is also a principal investigator with the Pittsburgh Institute for Neurodegenerative Diseases (PIND),
where she continues to be engaged in an active research program focusing on the role of mitochondria in
neurodegenerative diseases, particularly Parkinson’s disease (PD). Dr. Berman’s research focuses on the role of
mitochondrial dynamics in neurodegenerative diseases. Mitochondria, the energy-producing organelles in cells, are
dynamic in neurons, undergoing frequent division (fission) and fusion, and being transported in a regulated fashion.
These processes are critical for synapse function and formation, programmed cell death mechanisms, and protection
of mitochondrial DNA, and specific defects in mitochondrial fusion genes cause neurodegenerative diseases.
Mitochondrial dynamics have been increasingly implicated in neurodegenerative diseases, particularly PD, but these
mitochondrial processes have been very difficult to study directly, particularly in the brain. Using novel
methodology, Dr. Berman’s laboratory directly studies the role of mitochondrial dynamics in neurotoxicity of PD
models and aging, and her results have suggested that neurotoxicity can be affected by altering mitochondrial
dynamics. This year, Dr. Berman has five-year funding from the NIH National Institute of Neurologic Disorders
and Stroke and funding from the Parkinson Disease Foundation (PDF) for a collaborative project with Dr. Edward
Burton in the PIND, as well as PDF postdoctoral support for a separate project.
Dr. Berman continued as an active participant in the clinical training of residents and medical students this year
through lectures for neurology residents, and for the third-year medical student neurology lecture series. In addition,
she has continued to provide lectures around the academic community. She also provided clinical teaching to
residents and medical students during inpatient attending duties and outpatient clinics. She currently mentors two
postdoctoral fellows as well both an undergraduate and medical student.
Dr. Berman also continued her involvement in service to the PD patient community and sits on the Board of Directors
of the National Parkinson Foundation chapter, the Parkinson Foundation of Western Pennsylvania. This past year,
she worked with the Foundation to establish the monthly presence of the Foundation’s outreach director in the
Movement Disorders clinic, in order to provide information about available services and programs to any interested
patients with PD. She has also continued to serve on the United Mitochondrial Disease Foundation grant review
committee as well.
Over the course of the academic year Dr. Berman will continue to expand her research into mitochondrial
involvement in neurodegenerative diseases and will continue to publish and present her findings. She will continue
her clinical activities and expansion of the deep brain stimulator program in the Movement Disorders Division. She
will continue her work with the Alzheimer’s Disease Research Center. She plans to continue resident and medical
student teaching activities, and community service activities through involvement with the local Parkinson’s patient
advocacy group, the United Mitochondrial Disease Foundation, and educational outreach forums with local patient
support groups.
Edward A Burton, MD, DPhil, FRCP
Associate Professor of Neurology
Associate Professor of Molecular Genetics and Biochemistry
UPMC Endowed Chair in Movement Disorders
Dr. Burton is a movement disorders neurologist specializing in the diagnosis and
management of Parkinson’s disease (PD), progressive supranuclear palsy (PSP) and
dystonia. The central aim of Dr. Burton’s research work is to understand the mechanisms
underlying pathogenesis in these conditions and to develop more effective therapies to
control symptoms and mitigate disease progression. The Burton lab has taken two
complementary approaches to investigating the pathogenic mechanisms underlying these conditions:
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1. The zebrafish has many potential advantages for the study of neurological diseases and is especially
suitable for screening approaches to identify genetic and chemical modifiers, and to study gene-
environment interactions. In addition, zebrafish provide opportunities to carry out in vivo imaging studies,
since larvae are translucent. Dr. Burton’s group has identified and characterized the zebrafish homologues
of human synucleins and torsins implicated in PD and dystonia, generated transgenic and knockout
zebrafish models that replicate many of the biochemical and pathological features of PD, PSP, and
dystonia, and developed high-throughput neurobehavioral assays suitable for drug discovery applications
in these models.
2. Recombinant viral vectors can be used to deliver genetic material, including short RNA sequences that
reduce expression of genes involved in disease pathogenesis, to the brain. Dr. Burton’s group developed
a viral vector that targets the SNCA gene implicated in Parkinson’s disease; the vector reduces expression
of α-synuclein in the mammalian brain in vivo after intra-cerebral inoculation. In collaboration with J.
Timothy Greenamyre MD, PhD, Dr. Burton’s group showed that α-synuclein knockdown prevents motor
abnormalities and neurodegeneration in a rat model of Parkinson’s disease caused by exposure to an
agricultural pesticide implicated in the etiology of sporadic PD. These exciting results suggest that
therapies targeting α-synuclein may be useful in preventing the progression of PD.
Franca Cambi, MD, PhD
Professor of Neurology
Dr. Cambi joined the Department of Neurology at the University of Pittsburgh in June 2014.
Dr. Cambi’s research is focused on the functional, biochemical, molecular and clinical
underpinnings of myelin disorders. Her work has ranged from investigations on the basic
mechanisms that regulate oligodendrocyte differentiation and myelin formation to the
understanding of how disruption of their regulation leads to human myelin disease. In the
academic year 2016-17, her research group has shown that GSK3b is a regulator of
oligodendrocyte apoptosis using two experimental models of demyelination, toxic (cuprizone) and immune
mediated (Experimental Allergic Encephalomyelitis or EAE). Apoptosis is recognized as the main mechanism of
oligodendrocyte loss in Multiple Sclerosis caused either by immune mediated injury or a direct degenerative process.
The cuprizone is a model of degenerative oligodendrocyte loss and the EAE is a model of immune mediated
oligodendrocyte loss. By using a novel inducible conditional knockout (cKO) of GSK3b in mature OL, we have
shown that depletion of GSK3b protects OL from cell death induced by cuprizone and reduces demyelination.
Specifically, we show that GSK3b-deficient OLs are protected against caspase-dependent apoptosis resulting in
higher number of surviving mature OL and reduced activation of astrocytes and microglia. At peak of demyelination,
there is significant preservation of myelinated axons in the GSK3bcKO. These data demonstrate that GSK3b is pro-
apoptotic for caspase-dependent of oligodendrocytes and its depletion is sufficient to promote survival of
oligodendrocytes and attenuate myelin loss (manuscript in preparation). In preliminary studies with the MOG
induced EAE, we show that depletion of oligodendrocytic GSK3b attenuates the clinical course of motor deficits,
reduces OL loss and is associated with less demyelination. To gain an understanding of early molecular changes that
may mediate this protection and identify genes that are differentially expressed in the GSK3b cKO vs. controls, we
have performed gene-profiling studies by RNA Seq. We have found increased expression of “protective genes”
involved in apoptosis, survival and mitochondrial function in the GSK3bcKO and these represent targets for drug
development. These studies have discovered a novel previously unexplored function of GSK3b in OL cell death and open a new area of research aimed at target identification.
To determine the role of oligodendrocytes in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), we have
focused on a gene FUS, which is mutated in inherited and sporadic ALS and in Frontotemporal Lobe Dementia. We
have generated a cKO in which FUS is depleted in oligodendrocytes. The initial phenotypic characterization of the
FUS OL cKO has revealed an interesting behavioral phenotype consistent with hyperactivity and impulsivity.
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We have characterized motor function and activity longitudinally in the same cohorts of FUS fl/fl (FUS littermates)
and FUS OL cKO mice. Statistically significant interactions between genotype and age were identified in the FUS
OL cKO vs. FUS littermates for vertical time. Because vertical activity represents an exploratory behavior, the
greater vertical activity would suggest hyperactivity. Furthermore, the time spent in the center of the open field was
higher for the FUS OL cKO vs. FUS fl/fl littermates. Exploration of the center over periphery is an indication of
reduced anxiety-like behavior and would suggest impulsivity in the FUS OL cKO mice. Our collaborator Dr. Zhu
at the University of Kentucky has generated a cKO in which FUS is depleted in motor neurons where to examine
the role of FUS in motor neuron degeneration and loss.
Dr. Cambi has participated in residents teaching and clinical training during resident’s rotation in the neurology
outpatient and inpatient services. In addition, she has worked with one of the Movement Disorders Fellows in her
outpatient clinic.
In Academic year 2017-2018, we will perform molecular studies to examine the mechanisms by which GSK3b
protects oligodendrocytes against immune and non-immune apoptosis with the goal of identifying targets that can
be engaged in treatment strategies. We will characterize the spatial and temporal expression of selected genes
identified by RNA Seq in both models of demyelination. We will correlate their temporal and spatial expression
with OL cell loss and glial activation. These genes may represent novel targets for potential therapeutic interventions
in MS.
The initial characterization of FUS cKO in oligodendrocytes has revealed an unanticipated phenotype consistent
with hyperactivity and impulsivity. These findings are clinically relevant to the cognitive and behavioral defects
caused by FUS mutations in human disease and suggest that FUS deficient OL may contribute to cognitive deficits.
We will characterize further the behavioral defects by testing anxiety, exploratory and sociability behaviors in FUS
OL cKO and littermates. We will elucidate the neuroanatomical substrate by examining cortical and hippocampal
neuron number and their dendrite arborization. We will examine whether age-dependent motor neuron loss occurs
in the FUS cKO.
Dr. Cambi plans to continue her involvement with resident teaching and training in clinical settings and formal
lectures.
Eric K. Hoffmann, PhD
Research Assistant Professor of Neurology
Pittsburgh Institute for Neurodegenerative Diseases
Eric K. Hoffman, PhD, is conducting investigations to develop cell culture models of the
neurodegenerative processes associated with Parkinson’s disease (PD). Research efforts are
focusing on the use of CRISPR/Cas9 gene editing technology to generate knockout and knock-
in cell lines targeting genes linked to PD. Specific genes under investigation include the
LRRK2 kinase gene and the alpha synuclein gene. Point mutations in these genes have been
increasingly implicated in familial PD. Ongoing studies are characterizing mutations in the alpha synuclein gene
and how these alterations may influence aggregation of this protein. Also under investigation are cell lines containing
PD associated mutations in the LRRK2 gene. These lines are currently being characterized to determine the effect
these mutations have on kinase activity. Future studies will involve the use of these cell culture models under
conditions of oxidative stress to better understand how this factor contributes to the process of neurodegeneration.
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In the coming academic year, Dr. Hoffman plans to continue his research efforts on the mechanisms of oxidative
stress and neurodegeneration in Parkinson’s disease. Studies will focus on the use of CRISPR/Cas9 genome editing
methods as a means to further define the function of proteins that have been implicated in the etiology of Parkinson’s
disease.
In the coming academic year, Dr. Hoffman plans to continue his research efforts on the mechanisms of oxidative
stress and neurodegeneration in Parkinson’s disease. Studies will focus on antioxidant gene expression in response
to oxidative stress and the use of CRISPR/Cas9 genome editing methods as a means to further define the function
of proteins that have been implicated in the etiology of Parkinson’s disease.
Houman Homayoun, MD
Assistant Professor of Neurology
Dr. Homayoun is interested in clinical aspects of various movement disorders. His primary
interest is in chronic management of patients with Parkinson’s disease, atypical
parkinsonism, essential tremor, dystonia, tic disorders and Tourette Syndrome, Huntington’s
disease, medication-induced dyskinesia, myoclonus, blepharospasm, hemifacial spasm,
cerebellar ataxia, as well as uncommon movement disorders. He has a special interest in
the surgical treatment of movement disorders through deep brain stimulation. Dr.
Homayoun is the medical director of the multidisciplinary deep brain stimulation program at University of
Pittsburgh Medical Center and participates in pre-surgical assessment and post-surgical management of deep
brain stimulation therapy for patients with Parkinson’s disease, essential tremor, and dystonia. In this regard,
his main role is in patient selection and post-surgical programming of deep brain stimulation. This area is also
a focus of his clinical research interests as well. In addition, Dr. Homayoun is participating in the treatment of
patients with different movement disorders, primarily dystonia, with Botulinum Toxin injection. When needed,
he uses electromyogram (EMG) guidance for botulinum toxin injection into limbs and neck. Along with his
clinical duties, Dr. Homayoun also has a great interest in teaching neurology to residents and medical students
in both outpatient and inpatient settings and participate in didactic courses for neurology and internal medicine
residents.
Samay Jain, MD
Assistant Professor of Neurology
Clinical Director, Movement Disorders Division
Dr. Jain is Clinical Director of the Movement Disorders Division and Assistant Professor of
Neurology. He works in the Comprehensive Movement Disorders Clinic at University of
Pittsburgh Medical Center. Dr. Jain received a B.A. in Cognitive Science and M.D. from the
University of Virginia. He then went to the Cleveland Clinic for his Residency in Neurology,
followed by a Movement Disorders fellowship in the Neurological Institute at Columbia
University in New York City.
Dr. Jain is interested in developing accurate and early clinical diagnosis techniques and therapy for movement
disorders, as well as complications later in disease. He has presented research pertaining to Parkinson disease,
Tourette syndrome, essential tremor, dystonia, myoclonus, encephalitic movement disorders, historical neurology
and pediatric movement disorders. Currently he is investigating the non-motor features of Parkinson disease with
funding from the National Institutes of Health. This project aims to improve diagnosis and treatment of Parkinson
disease with assessments of non-motor features using clinical and physiologic measures. He is also site investigator
for a trial of exercise in Parkinson disease patients. Dr. Jain is also coordinating studies about Parkinson disease with
the Department of Epidemiology in the University of Pittsburgh Graduate School of Public Health. He has received
funding for his work from the NIH, Michael J. Fox Foundation, National Science Foundation, Tourette Syndrome
Association, and pharmaceutical companies.
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Dr. Jain has also established a movement disorder research registry for patients and a protocol for videographing
movement disorder patients. These videos are archived in a database where they are used for clinical, teaching and
research purposes. He coordinates Movement disorder video rounds for faculty, staff, medical education and health
care personnel. These rounds serve as a platform for discussion of movement disorders seen in clinic, helping
establish a collaborative and educational environment for patient care and education. Dr. Jain also regularly teaches
medical students, and helps coordinate a rotation for residents in the Movement disorders division. Dr. Jain is
director of the University of Pittsburgh Movement Fellowship.
In 2014, Dr. Jain lead team SPark which won the Pitt Innovation Challenge. SPark is a smartphone / smartwatch for
Parkinson disease. SPark uses motion sensors in smartphones and smartwatches, to detect and predict motor
problems and their relation to medication dose. It then optimizes medication schedules, which can be reviewed by
clinicians and sent to patients for real-time monitoring and efficient, easy communication.
Valerie Renee Suski, DO
Clinical Assistant Professor of Neurology
Clinical Director – Movement Division
Co-Director – Movement Disorders Fellowship Program
Dr. Suski joined the Department of Neurology in January 2008 after completing her Neurology
residency at Virginia Commonwealth University Health System/Medical College of Virginia
and a clinical Movement Disorders fellowship at Duke University.
Dr. Suski is an active member of the Movement Disorders Division providing evaluation and
treatments including botulinum toxin and deep brain stimulator programming to patients with a wide variety of
movement disorders.
She has been the director of the UPMC Huntington's Disease Clinic since July 2009. Since 2015, Dr. Suski was
awarded the Huntington’s Disease Society of America (HDSA) Center of Excellence and a grant that enabled her to
build this clinic. Now, the clinic is a multidisciplinary, including specialists in neurology, social work, genetic
counseling, physical therapy, occupational therapy, speech therapy, nutrition and clinical trials. It provides care for
both patients with Huntington's disease and their families in a ‘one-stop-shop’ fashion. She is a member of the
Huntington’s Study Group and is currently participating in 5 Huntington’s disease clinical trials.
Dr. Suski provides the services of the Movement Disorders Clinic through Telemedicine once a month to a remote
community location where this subspecialty is needed. She is especially interested in non-motor complications in
Parkinson's disease, atypical Parkinsonism, dystonia, tremor and Huntington's disease. She is also extremely active
in service to the Parkinson Support Group and Huntington Support Group community in the Western Pennsylvania
region.
Dr. Suski has been active in the clinical training of Neurology residents via the outpatient clinics, inpatient
Neurology ward and consultation services. She will be supervising the weekly Neurology Resident Continuity
Clinic. She also participates in medical student education, teaching them in the outpatient clinics and during the
inpatient services. In 2017, she became the Clinical Director of the Movement Disorder and co-Director of the
Movement Disorders Fellowship.
Over the course of the 2017-2018 academic year, Dr. Suski plans to continue her clinical activities and involvement
in the Comprehensive Movement Disorders Clinic. Other plans include curriculum development for the Movement
Disorders fellows and neurology residents with clinical skills teaching and assessment and deeper involvement in
medical student teaching, and academic writing.
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Neurocritical Care
Lori Shutter, MD, FCCM, FNCS
Professor, Critical Care Medicine, Neurology and Neurosurgery
Vice Chair of Education, Department of Critical Care Medicine
Director, Neurocritical Care Fellowship Program
Medical Director, Neurovascular & Neurotrauma ICUs
Dr. Shutter is the Vice Chair for Education in the Department of Critical care Medicine, directs
the Multidisciplinary Critical Care Fellowship Training Program, serves as medical director of
the Neurovascular and Neurotrauma ICUs, and leads development of the Neurocritical Care
(NCC) Program. Her clinical work is primarily in the Neurovascular and Neurotrauma ICUs where she cares for
patients with stroke, subarachnoid hemorrhage, status epilepticus, and traumatic brain injury.
During the past academic year Dr. Shutter has been participating in the Hedwig van Ameringen Executive
Leadership in Academic Medicine (ELAM) Fellowship. This prestigious and highly competitive program provided
her with intensive leadership training that included extensive coaching, networking and mentoring opportunities
aimed at expanding the national pool of qualified women candidates for leadership in academic medicine, dentistry
and public health. For the second year in a row she received a Presidential Citation from the Neurocritical Care
Society, and was named Faculty of the Year by the fellows in the Department of Critical Care Medicine.
She has lead efforts to strengthen collaborative relationships between critical care and the neurosciences through
educational activities, creation of clinical practice guidelines, and facilitating quality improvement and research
activities. Dr. Shutter continues her work with the Neurology Residency Curriculum Committee, as well as the
educational training and rotations in NCC for the Neurology Residency Training Program. She continues to actively
mentor neurology residents who are interested in NCC fellowship training.
NCC research activities occur both on an individual level and through collaborations with Neurosurgery, Neurology
and Emergency Medicine. Current projects in which Dr. Shutter has a leadership role include SHINE to evaluate
glucose control methods after stroke, Neurological Emergencies Treatment Trial (NETT) Network , and a study
looking at goal-directed management of neurocardiac injury after subarachnoid hemorrhage.
Sherry Chou, MD, MSc, FNCS
Visiting Associate Professor
Dr. Chou is a board-certified neurologist with subspecialty training and board certifications in
critical care and vascular neurology. Dr. Chou’s clinical practice focuses on patients with
critical injuries to their central nervous system. Her research focuses on the use of human
molecular biomarkers to probe mechanisms and predict outcomes in acute brain injury
conditions such as subarachnoid hemorrhage (SAH) and hypoxic ischemic brain injury from
cardiac arrest. She is funded with a K23 award, and the goals of this work include: 1) to better
define human pathophysiology of SAH-related vasospasm and brain injury using molecular
biomarkers, 2) to develop novel diagnostic molecular biomarkers in SAH, and 3) to define novel molecular
therapeutic targets for secondary brain injury in SAH. Dr. Chou also participates as co-investigator in multicenter
clinical trials in acute brain injuries including ischemic stroke, intracerebral hemorrhage, SAH, and traumatic brain
injury.
Dr. Chou has published over 50 papers, reviews and book chapters, and has received numerous honors for her
research and scholarly work contributions.
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Bradley Molyneaux, MD, PhD
Assistant Professor of Neurology
Dr. Molyneaux has been a member of the neurology faculty since 2013. He completed
neurology residency and neurocritical care fellowship at Massachusetts General Hospital and
Brigham and Woman’s Hospital at Harvard University. He shares an appointment in the
Department of Critical Care Medicine and is an attending neurointensivist in the Neurovascular
and Neurotrauma Intensive Care Units, where the patients he cares for include those with stroke,
subarachnoid hemorrhage, status epilepticus, and traumatic brain injury. He is also a member of
the Post Cardiac Arrest Service, providing consultative neurocritical care to patients after cardiac arrest.
Dr. Molyneaux is the site principal investigator for several multicenter clinical trials initiated during the past year,
including ATACH-II, which is testing whether early, intensive antihypertensive treatment is beneficial in
intracerebral hemorrhage, and GAMES-RP, which is testing whether glyburide can ameliorate malignant edema
after large ischemic strokes. As a member of the Post Cardiac Arrest Service, he is engaged in collaborative research
focused on optimizing the management of patients after cardiac arrest to improve outcome.
As a principal investigator in the Pittsburgh Institute for Neurodegenerative Diseases (PIND), Dr. Molyneaux’s
laboratory is investigating mechanisms of injury and repair of the cerebral cortex. By purifying individual subtypes
of projection neurons from the developing neocortex and sequencing their transcriptomes, he has identified
transcription factors that play critical roles in cortical projection neuron development, discovered novel noncoding
RNA’s that are unique to individual subtypes of neurons, and gained new insight into the complexity of the cortical
transcriptome. He is applying similar methods to identify new mechanisms of neuroprotection and plasticity after
injury.
Dr. Molyneaux teaches medical students, residents, and fellows who rotate in the neurocritical care units at the
University of Pittsburgh Medical Center. He is also the faculty advisor for the weekly Neurovascular and
Neurocritical Care lecture series, teaches in the medical student first year basic neuroscience course, and gives
lectures as part of the Critical Care Medicine Fellowship core lecture series.
In the coming year, Dr. Molyneaux will continue to care for patients in the Neurovascular and Neurotrauma Intensive
Care Units and teach medical students, residents and fellows. He will continue developing his basic and clinical
research program investigating mechanisms of neuroprotection and repair in the setting of stroke and traumatic brain
injury.
Ruchira Menka Jha, MD
Clinical Instructor Critical Care Medicine
Dr. Jha’s research focus is on cerebral edema using traumatic brain injury as a model under the
mentorship of Dr. Patrick Kochanek at the Safar Center for Resuscitation Research. Her specific
interest is on a pathway involving sulfonylurea receptor-1 and evaluating the role of this pathway
from multiple translational angles in human subjects as well as animal models. She is also
exploring this and related pathways in other neurological diseases that involve cerebral edema
such as cardiac arrest, ischemic stroke, and subarachnoid hemorrhage. Her current work is
supported by the NIH KL2 TR001856 grant.
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Research Projects over the past year:
▪ Characterization of the role of Sulfonylurea Receptor (SUR1) in cerebral edema in a combined injury mouse
model of controlled cortical impact and hemorrhagic shock.
This project involves evaluation of attenuation of cerebral edema by SUR1 blockade using the existing FDA
approved medication, Glyburide/Glibenclamide. A temporal-spatial map of SUR1 expression is also being
generated.
▪ Investigating whether SUR1 is measurable/quantifiable in human cerebrospinal fluid from patients with severe
traumatic brain injury. We have demonstrated that it is feasible to quantify SUR1 protein in human CSF in
traumatic brain injury. Levels are undetectable in controls, and elevated in traumatic brain injury. The trajectory
of Sur1 appears to correlate with measures of cerebral edema. Current studies are ongoing in a larger cohort of
patient to validate our findings.
▪ Investigating the impact of genetic polymorphisms in the SUR1 gene (ABCC8) on the development of cerebral
edema in patients with severe traumatic brain injury. Our work has revealed multiple single nucleotide
polymorphisms (SNP) that are associated with measures of cerebral edema and outcomes. The goal of this
project is to explore the potential functional significance of these SNPs.
Neuroimmunology/Multiple Sclerosis
Rock Heyman, MD
Associate Professor of Neurology
Chief, Division of Neuroimmunology/Multiple Sclerosis
Dr. Rock Heyman provides direct clinical care for over 1600 people with Multiple Sclerosis
(MS) and related disorders. He has a system for comprehensive care which includes not only on
site and in system multi-disciplinary care, but also integrates support services from many other
health and community programs including innovative programs to address domestic violence
issues and even support for companion animals of people with MS. He has developed the
department of neurology’s on-site infusion center, where both FDA approved and investigational
agents are given.
Dr. Heyman is an active advocate for people with MS as well as health care professionals treating and researching
MS. He devotes his efforts at the national level to working with the National MS Society (NMSS), serving on their
Medical Advisory Board (executive committee) and various task forces. He is a core member of the Comprehensive
Care Center Affiliation committee. Regionally Dr. Heyman serves the Allegheny District Chapter of the NMSS on
the Board of Trustees (executive committee), medical advisor, research advocate, and chairman of the Healthcare
Advisory Committee. Dr. Heyman also is a member of the Consortium of MS Centers abstract review committee.
Dr. Heyman’s educational efforts also center on Multiple Sclerosis. He lectures to the University of Pittsburgh
medical, physical therapy, and occupational therapy students as well other regional health care professionals. Dr.
Heyman is the lecturer for the medical school’s classes on MS and related disorders and teaches in the first year
medical school neuroscience small group sessions and problem based learning sessions. He has assisted in the
development of course materials for the Neuroscience Course. He has presented numerous CME programs
regionally and nationally as well as producing enduring CME materials for physicians and other health care
professionals as well as educational works (brochures, videos) for patients nationally. The clinical care he provides
at the Kaufmann Building site usually also involves teaching medical students, neurology residents, and fellows in
clinical MS care and spinal cord injury medicine. Dr. Heyman believes strongly in patient education and he supports
numerous patient support and education groups throughout the region and assists with both regional and national
media issues regarding MS.
Dr. Heyman is involved in all of the division’s multi-center research trials, as either a principle or co-investigator.
He currently supports research activities related to MS and Neuroimmunology in the department of Genetics
(leukodystrophy) as well as with Children’s Hospital White Matter Disorders program. He serves as either a
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treating physician or blinded examiner in trials of MS and is certified in the use of the EDSS and MSFC rating
scales. He has developed a Lumbar Puncture Clinic which assists patients, referring physicians, and research trials
with efficient acquisition of spinal fluid using state of the art techniques.
Dr Heyman plans continued expansion of his and his division’s services in all aspects of his mission, clinical care,
education, research, and advocacy.
Zongqi Xia, MD, PhD
Assistant Professor of Neurology and Biomedical Informatics
Dr. Xia joined the Department of Neurology in 2016 and holds a secondary appointment in the
Department of Biomedical Informatics. He is a core faculty member in the Pittsburgh Institute
for Multiple Sclerosis Care and Research and a principal investigator in the Pittsburgh Institute
of Neurodegenerative Diseases. He completed clinical training at Harvard-affiliated Partners
Neurology Residency Program (at Brigham and Women’s Hospital and Massachusetts General
Hospital) in 2009 and post-doctoral fellowship at the Brigham and Women’s Hospital, Harvard
Medical School and Broad Institute of Harvard University and Massachusetts Institute of Technology in 2013.
Dr. Xia leads the Laboratory of Translational Neurology and Neuroinflammation. His collaborative interdisciplinary
research team harnesses multi-dimensional patient-derived information (genomics, transcriptomics, epignomics,
microbiomes, immune profiling, electronic health records, biometric measurements, neuroimaging, cognitive
performance, and social structure) and deploys integrative quantitative science approaches to gain insights into the
underlying disease process and translate these findings into the clinical arena. The overall mission of his research
program is to bring precision medicine to multiple sclerosis (MS) and other related disorders of neuroinflammation
and neurodegeneration by providing individualized risk prediction,
prevention, and management.
Currently, there are three ongoing research initiatives. First, the research group is participating in a multi-centered,
prospective cohort study of individuals at risk for MS. Investigating the risk factors of MS and mapping the sequence
of events leading to the onset of disease will pave the way to ultimately test primary prevention strategies in high-
risk individuals. Second, the research group is conducting a longitudinal prospective cohort study to investigate the
biological and clinical predictors of disease course and treatment response in MS. Gaining insights into the factors
that influence the variable patient response to treatment and the diverse trajectories of disease progression in MS
will be the key to provide individually tailored therapy. Third, the research group is developing computational
approaches to ascertain treatment response and testing algorithms that predict treatment response using electronic
health records data. Tools that leverage real-life clinical data for outcome prediction in chronic neurological
disorders have the potential for widespread dissemination at the point of care.
Dr. Xia currently receives funding from two NIH grants: K08 and R01. In addition, Dr. Xia is the site PI of the
International Multiple Sclerosis Microbiome Study (iMSMS). The goal of this consortium project is to investigate
the gut microbial profiles characteristic of multiple sclerosis patients through the use of genetic and molecular
biology techniques and study the extent to which an individual’s genetics affect the gut microbiome. Finally, Dr.
Xia is the site PI of two multi-center clinical trials: (1) PCORI-funded trial called “Discontinuation of Disease
Modifying Therapies (DMTs) in Multiple Sclerosis (MS)”; (2) University of Texas Southwestern-sponsored trial
called “Multi-center, randomized, double-blinded assessment of Tecfidera in extending the time to a first attack in
radiologically isolated syndrome (RIS) (ARISE)”.
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Dr. Xia has published five peer-reviewed articles, including one first author research article in JAMA Neurology,
two senior author articles in Neurology and an editorial in the NEJM.
Islam Zaydan, MD
Assistant Professor of Neurology
Dr. Zaydan joined the Department of Neurology in October 2010. He completed his Internal
Medicine training in Egypt and in Marshall University SOM. His medicine training was
followed by a Neurology residency and a clinical Neuro-Ophthalmology fellowship at Virginia
Commonwealth University Health System/Medical College of Virginia. He was on the faculty
at Virginia Commonwealth University Health Systems for 4 years following his training.
Dr. Zaydan is an active member of the Comprehensive UPMC Multiple Sclerosis Center
providing evaluation and treatments of patient with central demyelinating disease. This is a multidisciplinary center
consisting of physicians, social workers, physical therapists, and clinical trial coordinators that provides care for
both patients with Multiple Sclerosis, Devic’s disease and their families. He was a board member of the Virginia
Chapter of the MS society and is currently participating in several Multiple Sclerosis clinical trials.
Dr. Zaydan is a fellowship trained neuro-ophthalmologist and holds a joint appointment at the UPMC
Ophthalmology Department (UPMC Eye and Ear Institute)/Neuro-Ophthalmology Division where he provides
evaluations and treatments of various neuro-ophthalmologic problems including ocular motility disturbances, optic
nerve diseases, and visual field/perception disturbances. He has written several chapters on the striate cortex and
cerebellum and has presented at the North American Neuro-Ophthalmology Society annual meetings.
Dr. Zaydan is especially interested in optic nerve diseases, as well as ocular motor and visual perception
complications of MS and is active in service to the Multiple Sclerosis Support Group community in the Western
Pennsylvania region.
Neuromuscular Diseases
David Lacomis, MD
Professor of Neurology and Pathology
Chief, Division of Neuromuscular Diseases
Director of Clinical Research, Live Like Lou Center for ALS Research
Co-Director, Clinical Neruophysiology Fellowship Program
Dr. Lacomis is the director of the Muscular Dystrophy Association Clinic and MDA-ALS Center
and the Director of Clinical Research for the Live Like Lou Center for ALS Research in the
University of Pittsburgh Brain Institute, specializing in amyotrophic lateral sclerosis (ALS),
myasthenia gravis, and muscle diseases. He is the co-director of the EMG Laboratory at UPMC
Presbyterian and the director of the Autonomics Laboratory, and he also serves as an assistant director of the Clinical
Neurophysiology Fellowship Program in charge of the EMG component. He is in charge of the Neuromuscular
Pathology Service. He remained active in teaching medical students in the Neuroscience Course and housestaff from
Neurology and Pathology. Dr. Lacomis was again named among the Top Doctors by Pittsburgh Magazine and in
Best Doctors and Top Doctors nationally.
Dr. Lacomis has been involved in a number of major ALS research projects in the past year. He is the site principal
investigator (PI) for an ongoing multi-center study for the discovery and validation of biomarkers obtained by serial
assays. Biofluid acquisition is complete, and projects are ongoing. He is also the site PI of a DNA banking study in
collaboration with investigators from the Mayo Clinic Jacksonville. He is a site Co-PI in a study of mexiletine in
ALS and the site PI in another biomarker study with deep phenotyping and comprehensive
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evaluation of the disease course including measures such as transcranial magnetic stimulation and motor unit number
estimation. With ALS investigator Christopher Donnelly, he is developing an institutional DNA and biofluid
repository for ALS research. Along with collaborators from the Brain Institute, he is developing an induced
pluripotent skin stem cell program. Dr. Lacomis continues to collaborate with colleagues from the division of
Rheumatology in studying autoimmune myopathies and serves on the Adjudication Committee for the study of
“Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis” with Chester V. Oddis, Sponsor
Investigator.
Dr. Lacomis also worked with former fellows David Avila and Diana Mnatsakanova on several projects resulting in
a case presentation entitled, “Quadriceps sparing weakness in a young woman”, at the AANEM annual meeting,
an AANEM case report on thoracic outlet syndrome for CME, and book chapters on topics including thoracic outlet
syndrome, GNE myopathy, and the use of diagnostic testing in neuromuscular disease.
Dr. Lacomis held a workshop on “When is Muscle Biopsy Useful in Evaluation and Management of Myopathy?” at
the annual American College of Rheumatology meeting, presented a lecture on “Repetitive Nerve Stimulation in
Neuromuscular Junction Disorders” at the ASET Annual Conference, and lectured on “Electrodiagnostic Approach
to Weakness in the ICU setting,” at the Twenty-sixth Annual Electrodiagnostic Medicine Course, UPMC Health
System.
Dr. Lacomis serves on the Scientific Advisory Committee for the Myasthenia Gravis Foundation of America, and is
on the editorial board of the Journal of Clinical Neuromuscular Diseases. He co-authors a section on “What’s in the
Literature” for each edition of the Journal of Clinical Neuromuscular Disease.
William Musser, MD
Clinical Assistant Professor
Dr. Musser is a Clinical Assistant Professor in the Department of Psychiatry at the University of
Pittsburgh School of Medicine. He teaches neurology to psychiatry residents in their longitudinal
course. He also serves as a consultant in Forensic Neurology cases in Western Pennsylvania.
Araya Puwanant, MD Assistant Professor of Neurology
Dr. Puwanant pursues clinical research focused on myotonic dystrophy, myasthenia gravis, and
neurologic channelopathies. The genetics, pathophysiology, and developing new approaches to
treatment of myotonic dystrophy is her primary area of interest. This includes investigations of
biomarkers as well as optimal outcome measures and clinical trials. She was a past recipient of
the Muscular Dystrophy Association (MDA) Clinical Research Training Grant and was an
investigator for the NIH-funded Wellstone Muscular Dystrophy Cooperative Research Center.
Currently, she is PI on a longitudinal study of Sub-Regional Body Composition and Clinical
Endpoints in Myotonic Dystrophy, funded by the MDA. She serves as a site PI on a PCORI-funded study for
Comparative Effectiveness of Disease-Modifying Treatments for Myasthenia Gravis. Furthermore, she is co-
investigator in ALS DNA and biomarkers study and an open-label clinical trial of intravenous infusion of ATB200
co-administered with oral AT2221 in adult subjects with Pompe Disease. Dr. Puwanant also serves on the Advisory
Committee for the NINDS funded NeuroNEXT Clinical Research Site at the University of Pittsburgh and the
Medical and Scientific Advisory Board of the Myasthenia Gravis Foundation of America (MGFA).
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Dr. Puwanant evaluates patients in the Neuromuscular Clinic and ALS Multidisciplinary Clinic, sponsored by the
MDA, at the Kaufman Medical Building. She provides electromyography (EMG) service at UPMC Presbyterian
and Shadyside and performs single fiber EMG at the Presbyterian EMG Lab. She directs Neuromuscular Clinic and
provides inpatient consultation service at UPMC Shadyside Hospital. The active teaching service also comprises
medical students and residents. In addition, she teaches a didactic course for first year medical students on Muscle
Cellular and Pathologic Basic of Disease and offers multiple lectures in the Neuromuscular Lecture Series for
neurology residents and fellows.
In the coming year, Dr. Puwanant will continue working on her MDA and PCORI funded studies, developing her
clinical research program on myotonic dystrophy, as well as collaborating with other investigators. She will serve
on the Advisory Committees for the NeuroNEXT Clinical Research Site at the University of Pittsburgh and the
MGFA. She is planning to submit the NINDS career development award (K23) in 2018. She will complete and
submit 2 manuscripts related to outcome measures in myotonic dystrophy. In addition, she will continue her clinical
activities as a neuromuscular and EMG specialist at UPMC Presbyterian and Shadyside.
Saša Živković, MD, PhD
Associate Professor of Neurology
In the academic year July 1, 2016 through June 30, 2017, Dr Zivkovic continued his clinical and
research work focusing on amyotrophic lateral sclerosis, peripheral neuropathy and neurologic
complications of organ transplantation.
Dr. Zivkovic specializes in the treatment of patients with neuromuscular disorders and
participates in the work of the MDA Neuromuscular Clinic and MDA-ALS Multidisciplinary
Clinic. He evaluates patients in neuromuscular clinic and performs electrodiagnostic testing at
Presbyterian and UPMC Shadyside hospitals EMG labs and performs approximately 400 EMG
and nerve conduction studies annually. Dr. Zivkovic remains active in clinical research as a member of the North-
Eastern ALS Consortium (NEALS), and Inflammatory Neuropathy Consortium (INC). He is a site investigator on
a multicenter study treatment of familial amyloid neuropathy with patisiran.
As a working group member of Brighton Collaboration (Working groups on vasculitis and vasculitic neuropathy),
he has co-authored four studies studies on association of vaccination with SLE, vasculitis and vasculitic neuropathy
in Vaccine. Drs Zivkovic, Ali and El-Dokla have also contributed a chapter on spinal cord organization to Conn’s
Translational Neuroscience, edited by Dr Michael Conn. In collaboration with Dr Mnatsakanova, Dr Zivkovic has
published a review on iatrogenic amyloid neuropathy after domino liver transplantation in World Journal of
Hepatology. In collaboration with Drs Gonzalez and Puwanant, he co-authored a manuscript on myasthenia gravis
triggered by immune checkpoint inhibitors in Neuromuscular Disorder. He also continued his clinical research on
the evaluation of neuromuscular function and peripheral neuropathy in the elderly in collaboration with Dr. Else
Strotmeyer, Graduate School of Public Health which resulted in 2 publications.
Dr Zivkovic actively participates in the education of medical students at the University of Pittsburgh, and teaches in
the course Neuroscience and Clinical Neuroscience Clerkship. He has also been teaching neurology and PM&R
residents and clinical neurophysiology fellows in EMG lab, outpatient clinics and inpatient neurology service at
UPMC Presbyterian, and has received the award for Excellence in Clinical Teaching in Neurology residency
program at UPMC. Dr Zivkovic was selected again by his peers as one of Best Doctors in America (Best Doctors,
Inc.). He serves as an editorial advisory board member for World Journal of Hepatology. He also served as an ad
hoc reviewer for journals Muscle and Nerve, Neurology, Transplantation and Transplantation International.
In academic year 2017-2018, Dr. Zivkovic will participate in clinical treatment trials of ALS at UPMC with Dr.
David Lacomis, and will continue clinical research on peripheral neuropathy, and on decline of peripheral nerve
function in elderly. He will serve as site PI for Pittsburgh site of multicenter study on treatment of ALS with
mexiletine and as site PI for Pittsburgh site of multicenter study on treatment of familial amyloid neuropathy with
patisiran. He will also continue clinical research on inflammatory neuropathies and neurologic complications of
organ transplantation.
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Neuro-Oncology
Frank S. Lieberman, MD
Professor of Neurology and Medical Oncology
Director Adult Neuro-Oncology Program UMPC Cancer Center
Dr. Lieberman is director of the adult neuro-oncology program at UPMC Cancer Centers. His
clinical and research efforts encompassed both the treatment of primary CNS tumors and the
neurological complications of cancer. Brain tumor translational investigations focus on the
application of molecular genetic techniques and functional imaging techniques to develop
strategies for individually optimized molecularly targeted treatment of patients with malignant
gliomas, the most common brain tumors in adults.
Dr. Lieberman serves as institutional principal investigator for UPMC in the Adult Brain Tumor Consortium He is
the institutional representative for CNS tumor committees for the NRG, and ECOG-ACRIN oncology clinical trials
consortia. He serves on the Experimental Imaging and Biomarkers committees for ECOG-ACRIN and is the
former chair of the Clinical Trials Design and Development committee for the Quantitative Imaging Network.
Dr. Lieberman is a member of the phase 1 and phase 2 centers in UPMC Cancer Center and one of the faculty
directing institutional participation in the NCI Experimental Therapeutics National Clinical Trials Network.
In collaboration with Jan Drappatz (co-director Neurooncology Program), Ron Hamilton, and Marina Nikaforovna,
Dr. Lieberman is applying Next Generation Sequencing techniques to the development of individualized molecular
therapies for patients with malignant gliomas. UPMC is one of an elite group of cancer centers with CLIA approved
NGS for use in patients undergoing resection for cancer. Drs. Lieberman and Drappatz are the neurooncology
program investigators in UPCI’s molecular pathology database program in which patients whose tumors are
analyzed by NGS participate in a database associated with the UPCI Phase 1 Trials Center. This allows for
identification of potential subjects for molecularly targeted therapeutic clinical trials across tumor types.
Dr. Lieberman has a national leadership role in the development of vaccines for treatment of gliomas. In
collaboration with Dr. Hideho Okada, Dr. Lieberman served as principal investigator for one of the first dendritic
cell vaccine trials for low grade gliomas and coinvestigator for similar trials in high grade gliomas. Despite Dr.
Okada’s relocation to University of California, San Francisco, these collaborations have continued, and the arrival
of Dr. Gary Kohenbash in January 2017 begins a new collaboration testing immunotherapeutic strategies for patients
with glioblastoma.
Dr. Lieberman is also collaborating with Dr. Sameer Agnahotri, recruited in October, 2016, to expand the molecular
genetics program begun in collaboration with Dr. Nikaforovna to include intracranial mouse models of glioblastoma
and medulloblastoma. Dr. Agnahotri’s will be using these models to test candidate molecularly targeted therapeutic
agents in preclinical studies to optimize the choice of agents for human clinical trials.
Dr. Lieberman Previously served as the chairperson of the Clinical Trials Design working group for the Quantitative
Imaging Network and continues collaborations with Dr. James Mountz in the development of novel PET tracers for
assessing tumor response in clinical trials for glioblastoma. In collaboration with Dr. Mountz, Dr. Kohenbash, Dr.
Ashok Panigrahy, and Dr. Carolyn Anderson, Dr. Lieberman is exploring novel techniques for monitoring delivery
of effector T cells and tumor response in clinical trials of Chimeric Antigen Recptor T Cells.
Dr. Lieberman continues to collaborate in projects, led by Paula Sherwood, addressing caregiver stress in families
of patients with primary brain tumors.
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Dr. Lieberman directs the clinical Neuro-Oncology program for UPMC Hillman Cancer Center, is director of the
neuro-oncology rotation at UPMC Hillman-Shadyside for neurology residents and fellows and is an attending for
Neurology house staff morning report. He provides neuro-oncology consultation service for UPMC Presbyterian,
Magee, and Shadyside hospitals. He directs the Neuro-Oncology Tumor Board; a weekly CME category 1 approved
academic teaching case management conference and a monthly Neuro-Oncology Tumor Board conference at UPMC
Shadyside which is a case presentation and topic review format for the oncology community. He also serves on the
bioethics committee at UPMC Shadyside.
Dr. Lieberman is a member of the Society for Neuro-Oncology and the Neurooncology Section of the American
Academy of Neurology. He currently serves on the committee administering the subspecialty neurooncology board
examination for the United Council of Neurologic Specialities. He is a member of the American Association of
Cancer Researchers and American Society of Clinical Oncology.
Dr. Lieberman has a long interested in the intersection between religion and medical practice, and the application of
the principles of Jewish religious law to clinical bioethics. He is a member of a working group of faculty in the
University of Pittsburgh School Of Medicine, the law school, and the Religious Studies Program, aspiring to develop
a program for religion and medicine at University of Pittsburgh. He is the director of a new clinical case conference
addressing how religious faith affects the care of patients form both patient and physician perspectives.
Jan Drappatz, MD
Associate Professor of Neurology
Associate Director, Adult Neurooncology Program
As a board- certified neurologist specializing in the field of neuro-oncology, my primary areas
of research involve the development of novel agents for the treatment of glioblastoma, central
nervous system lymphoma, and other primary and metastatic brain tumors. I have served as the
principal investigator of numerous clinical trials to identify effective therapies for patients with
brain tumors and other neurological ailments associated with cancer.
Research Division
Guodong Cao, PhD
Associate Professor of Neurology
Dr. Cao and his group continue his projects to investigate the effect of nicotinamide
phosphoribosyl transferase (NAMPT) on white matter restoration and neurovascular remodeling
after brain ischemia funded by NIH and the Department of Veteran Affair. Recently he
established a novel approach to convert reactive astrocytes surrounding infarct core into
oligodendrocytes in situ in brain ischemia. This approach will not only convert detrimental
astrocytes into beneficial oligodendrocytes, which can restore damaged white matter, but also
prevent the formation of astrocytic scar. This novel finding has been funded by the Department of Veteran Affair.
Dr. Cao is also investigating whether reprogrammed oligodendrocytes will enhance cognitive functional
improvement following brain ischemia as well as white matter and neurological restoration in traumatic brain injury.
Dr. Cao has served on the Editorial Board for 16 journals.
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Jun Chen, MD
Professor of Neurology and Pharmacology
Dr. Chen’s laboratory studies the cellular and molecular mechanisms underlying neuronal
degeneration and brain repair in models of cerebral ischemia or traumatic brain injury (TBI). A
number of publications from this lab have had major influence on the field and are among the
most cited manuscripts in journals. Having been engaged in the field for 25 years, the most
significant contributions from Dr. Chen’s laboratory include the findings on: 1) the role of
mitochondrial signaling pathways in neuronal death and brain dysfunction in various neuronal
injury models; 2) the role of oxidative DNA damage and repair in ischemic brain injury and
recovery; 3) the role of microglial/macrophage polarization as a double-edged sword in ischemic brain injury and
repair; and 4) the role of microglia and oligodendrocytes in white matter repair after stroke or TBI. The current focus
of Dr. Chen’s laboratory is three-fold. The first focus is to determine the role & mechanism of endothelial
dysfunction and immunological responses (microglial/macrophage polarization, infiltration and reprogramming of
circulation immune cells) in the pathogenesis of blood brain barrier damage, neurovascular dysfunction and
neurological deficits after stroke. The second focus is to investigate how white matter injury and repair may
contribute to long term neurological deficits & recovery after stroke or TBI, with particular focus on demyelination
and remyelination mechanisms. The third focus is to extend the long term research on the base excision repair (BER)
pathway of DNA repair into an exciting new era, i.e. studying the role of DNA repair (through the newly discovered
long-patch BER pathway) in functional recovery after stroke.
Dr. Chen has actively participated in teaching graduate students. He is a training faculty member of the CNUP and
MD/PhD programs and a dissertation advisor for graduate students. Dr. Chen teaches two different graduate study
courses (Cell and Molecular Neurobiology MSNBIO 2100 and Neuropharmacology MSMPHL 3375). He has been
a PhD advisor of the neuroscience program at Fudan University since 2004.
Dr. Chen has continued to serve at national and international levels. He is a member of study sections NIH, AHA,
and VA, and also serves as a reviewer or consul member for various international science foundations. He is the
current Treasurer of the International Society of Cerebral Blood Flow and Metabolism. He serves as an editorial
board member for 13 professional journals, including Journal of Neuroscience, Journal of Cerebral Blood Flow and
Metabolism, Stroke, Neurobiology of Disease, and Progress in Neurobiology, etc.
Paula R. Clemens, MD
Professor of Neurology
Chief, Division of Veterans Affairs
During the academic year from July 1, 2016 to June 30, 2017, Dr. Clemens provided leadership
for the Neurology Service at the VA Pittsburgh Healthcare System (VAPHS) and served as a
Vice Chair for the Department of Neurology. She directed an out-patient and consultation service
with 9 part-or full-time neurologists and 3 neurology resident physician positions at VAPHS.
The active teaching service also comprised third and fourth year medical students, geriatrics
fellows and geriatric psychiatry fellows during the course of the year. More information on the
VAPHS Neurology Service is included elsewhere in this annual report. Dr. Clemens chairs the Institutional Biosafety
Committee at VAPHS.
Dr. Clemens pursues basic and clinical research focused on discovering and improving treatment of skeletal muscle
diseases. Her basic research projects include characterization of the molecular pathology of mouse models of muscle
wasting in muscular dystrophy, muscle injury, idiopathic inflammatory myopathy and nerve injury. The Clemens
Laboratory explores the modulation of NF-B signaling pathways for amelioration of the skeletal muscle phenotype
and modulation of immunity in these disorders. Human clinical research studies directed by Dr.
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Clemens include leadership as the Medical Director of a multi-center academic trials group devoted to the study of
therapeutic agents for patients with muscular dystrophy, the Cooperative International Neuromuscular Research
Group (CINRG). Dr. Clemens serves on the Data Safety Monitoring Board for a study sponsored by Pfizer, Inc. and
2 studies sponsored by the NIH.
Dr. Clemens co-directs an NIAMS-funded P50 Center of Research Translation of Systemic Exon Skipping for
Muscular Dystrophy and an NINDS-funded NeuroNEXT clinical study site. NeuroNEXT is a nationwide clinical
trials network established to conduct neuroscience clinical trials. The University of Pittsburgh is an active enrolling
site in ongoing NeuroNEXT trials. She also leads a Department of Defense-funded clinical treatment trial in
muscular dystrophy. Dr. Clemens is the chair for a multi-center DMD treatment trial for a new dissociative steroid
that is funded in part by an NIH Small Business Innovations Research grant as well as other sources. Furthermore,
Dr. Clemens is the chair for a multi-center DMD treatment trial for exon 53 skipping therapy, sponsored by NS
Pharma, Inc.
Dr. Clemens leads the clinical and research activities in late-onset Pompe disease at the University of Pittsburgh.
She manages lumizyme infusion therapy for patients with late-onset Pompe disease. She is the University of
Pittsburgh site investigator for the Pompe Registry and also serves on the Pompe Registry Board of Advisors. She
is site PI for an industry-sponsored treatment trial in adult-onset Pompe disease.
Dr. Clemens precepts third and fourth year medical students rotating on the VAPHS Neurology Service. She is a
career advisor for students in the Medical Scientist Training Program (MSTP) and the Physician Scientist Training
Program (PSTP).
Dr. Clemens is a member of a steering group organized by the Centers for Disease Control to update the Care
Considerations for DMD that will be published during the coming year, and she also participated as a working group
member to prepare a comprehensive document of ‘Management of Cardiac Impairment in Neuromuscular Disease’
for the American Heart Association.
In the coming year, Dr. Clemens will continue her basic and clinical research program in the treatment of
neuromuscular disease. She will continue her clinical activities as a neuromuscular specialist, her involvement in
the neurology residency clinical training program, and her leadership of the neurology service at VAPHS.
Steven H. Graham, MD, PhD
Connolly Family Chair in the Stroke Institute
Professor and Vice-chairman for Research
Director, Geriatric Research Educational and Clinical Center
Associate Chief of Staff for Research, VA
Dr. Graham’s research focuses on the mechanisms by which neurons die after stroke and brain
trauma. Ongoing research projects address the role of the the protein, UCH-L1 also known as
Parkin 5 in stroke, traumatic brain injury and neurodegeneration. UCHL1 activity is required
to maintain axonal transport and synaptic function. New findings this year have shown that
axonal injury in mice with traumatic brain injury may be reduced by treatment with a novel protein fusing UCHL1
and elements of the prothrombin domain of the HIV capsid protein TAT. This novel protein readily enters the brain
and neurons when given systemically. These and other findings lead to the funding of new R01 award from NIH
NINDS to explore the role of UCHL1 in the pathogenesis and treatment of TBI.
Dr. Graham is the Director of the Geriatric Research, Educational and Clinical Center (GRECC) at the VA. The
GRECC is a multidepartmental center that aims to develop new treatments, educate providers and students and pilot
new methods of delivering clinical care for elderly Veterans. The research foci of the GRECC includes stroke,
traumatic brain injury, Alzheimer’s disease, communication disorders, and cardiac rehabilitation. Dr.
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Graham is also serving as Associate Chief of Staff for Research at the VA. As Vice-chair for Research of the
Department of Neurology he oversees the rapidly growing research program of the Department. Dr. Graham
precepts medical students and residents on the inpatient services at the VA. He is also a staff neurologist at the VA
with a special interest in stroke and dementia.
Dr. Graham will continue his ongoing NIH-funded studies regarding the mechanisms by which UCHL1 restores
axonal function in stroke and TBI. As GRECC Director, he plans to recruit new faculty and further develop its
research program in cerebrovascular disease and geriatrics.
Teresa G. Hastings, PhD
Associate Professor of Neurology
Pittsburgh Institute for Neurodegenerative Diseases
Dr. Hastings is a member of the Pittsburgh Institute for Neurodegenerative Diseases (PIND).
Her research examines the role of dopamine oxidation, ROS formation, protein modification,
and mitochondrial dysfunction in the selective vulnerability of dopaminergic neurons. The goal
of her work is to identify therapeutic agents to prevent neurodegeneration associated with
Parkinson’s disease, drugs of abuse, and aging in general. Using proteomic techniques, Dr.
Hastings’ laboratory is identifying mitochondrial and intracellular proteins that show changes
in expression, oxidative modification, or aggregation following exposure to dopamine and other oxidative stressors.
This is an important step in linking alterations in critical protein structure and function to the death of the neuron.
New projects in the lab include examining the neuroprotective effect of dietary selenium and the role of
mitochondrial selenoproteins in preventing neurotoxicity.
Dr. Hastings is active in the Center for Neuroscience (CNUP) Graduate Program. This year she served on 8 graduate
student committees. She is the Director of and a lecturer in Block 1 of the CNUP graduate course Cellular and
Molecular Neurobiology. She also lectures in other courses. This year, Dr. Hastings is mentoring two postdoctoral
fellows, one graduate student, and one undergraduate student in the laboratory, and serves as the career advisor for
four MSTP students. She serves as training faculty on two institutional training grants including “NIH Medical
Scientist Training Program (R. Steinman, Director) and "NIH Predoctoral Training in Basic Neuroscience" (A.F.
Sved, Director). Dr. Hastings is also the Co-Director of the Honors College Health Sciences Undergraduate Summer
Research Program.
Dr. Hastings is a member of the MSTP/CNUP Admissions/Recruitment Committee, the Department of Neurology
Promotions Committee and the Tenure Stream Review Committee and the Executive Committee for the Pittsburgh
Institute for Neurodegenerative Diseases (PIND). She is also a member of the Steering Committee for the NIH
Institutional Predoctoral Training Grant, the Medical Scientist Training Program (MSTP) Steering Committee, the
Competitive Medical Research Fund (CMRF) Standing Review Committee, and the University Council on Graduate
Study. This year, Dr. Hastings was named as an Honors College Faculty Fellow with the University of Pittsburgh
Honors College.
Xiaoming Hu, MD
Research Assistant Professor of Neurology
Dr. Hu’s core research interests are to explore the immune-related mechanisms of ischemic
stroke and neurodegenerations, and to develop immunotherapies to treat these conditions. Last
year, her main research directions were on 1) exploring the protective effect of regulatory T
cells (Tregs) in models of stroke, and 2) exploring “recovery-enhancing drugs” that not only
promote gray matter integrity but also enhance white matter recovery after stroke.3)
Characterize microglia/macrophage polarization after stroke and identify the molecular switches
in microglia/macrophages that control phenotypic change.
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Milos D. Ikonomovic, MD
Associate Professor of Neurology
Over the past academic year, Dr Ikonomovic and his research team have made several major
advances in studies examining the pathobiology of two inter-related neurodegenerative
conditions, chronic traumatic brain injury (TBI) and Alzheimer’s disease (AD). Dr. Ikonomovic
received new R01 award to design, produce, and characterize novel radioligands for labeling
toxic deposits of amyloid-beta (Aβ) peptide in brain blood vessels, for use in future PET imaging
studies in living AD patients. He is also Principal Investigator on a project funded by the
Department of Veterans Affairs’ RR&D, to examine AD related pathology changes during
chronic periods after blast injury in transgenic PSEN1dE9 mice and how these changes are associated with axonal
pathology imaged in vivo, a collaborative project with investigators from VA Iowa City Medical Center. Dr.
Ikonomovic is also Principal Investigator on a VA MERIT Review Award “Novel multifunctional rehabilitative
therapy to reduce Alzheimer pathology after TBI”. He also leads a project within the NIA-funded PPG
“Neurobiology of Mild Cognitive Impairment” (PI Dr. Elliott Mufson, Barrow Neurological Institute), examining
alterations in Aβ metabolism, synaptic integrity and cholinergic function in mild cognitive impairment (MCI) and
early AD. New study from Dr. Ikonomovic’s laboratory demonstrated that brain amyloid deposits detectable using
PET ligand [C-11]PiB are associated with loss of dendritic spines in the precuneus neocortex, possibly reflecting
synaptic dysfunction and cognitive impairment during the progression of PET-detectable pathology (findings were
presented at the ADPD 2017 conference). Dr. Ikonomovic also leads a project within the NIH-funded PPG “In Vivo
PET Amyloid Imaging: Normals, MCI, and Dementia” (PI Dr. William Klunk, Department of Psychiatry). On this
project, Dr. Ikonomovic’s laboratory characterized neuropathological substrates for binding of PiB and a novel tau
PET ligand AV-1451, by conducting postmortem histological and biochemical analyses of Aβ and tau and
correlating this pathology with PET measures recorded in the same subjects antemortem.
Dr. Ikonomovic continued to work as Co-Investigator on several projects, including collaboration with Dr. Robert
Sweet (Department of Psychiatry), examining if changes in cortical soluble Aβ and tau concentrations can
differentiate AD patients with psychoses relative to AD patients without psychoses. Dr. Ikonomovic also
collaborates with Dr. Chester Mathis (Department of Radiology) and Dr. William Klunk (Department of
Psychiatry) on a project funded by the Michael J. Fox Foundation, to design and test novel compounds selective
for alpha-synuclein aggregates. Dr. Ikonomovic is Co-Investigator on several other studies, with Dr. David
Okonkwo (Department of Neurosurgery) on the Department of Defense study to develop an in vivo
neuroimaging biomarker panel for chronic traumatic encephalopathy; with Dr. Ben Handen (Psychiatry) on a
PET, MRI, and plasma biomarker study of adults with Down syndrome; and with Dr. C. Edward Dixon on an
R01 study evaluating alpha-synuclein and synaptic dysfunction after TBI.
During the next academic year, Dr. Ikonomovic will continue to work on his current studies, collaborations, and
several new research investigations. He will continue to train fellows and students in his laboratory. He serves on
the VA Research Scientific Evaluation Committee, and provides consultant services to Neuropathology Core of
the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC) and to GE Healthcare. He also serves
as an associate editor for the journal Cardiovascular Psychiatry and Neurology, and Review Editor for the journal
Neurotrauma. He is a grant reviewer for the Alzheimer Association’s International Research Grant Program and an
ad-hoc grant reviewer for NIH and VA Scientific Review groups.
Hao Liu, MD, PhD
Research Assistant Professor
Dr. Liu’s research interest focuses on the molecular mechanisms underlying neuronal cell injury
after stroke and brain trauma and potential novel therapeutic approaches. Specifically, Dr. Liu
and his colleagues, supervised by Dr. Steven H. Graham, are studying the role of cyclopentenone
prostaglandins (CyPGs) and some important enzymatic proteins in post-
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ischemic and post-traumatic neuronal injury. Their work has shown that the generation of CyPGs is highly increased
after stroke and trauma. This excessive CyPG production induces neuronal cell death by adducting and unfolding
many essential proteins. One of the CyPGs’ targets is UCH-L1, which is an abundant protein expressed strictly
within the neuronal system and it’s mutation and modifications have been linked to many neurodegenerative diseases
such as Parkinson’s disease. Dr. Liu’s other ongoing projects address the role of UCH-L1 in neuronal cell survival
and axonal repair under a variety of pathological conditions, including hypoxia and trauma. To facilitate their
research, two knock-in transgenic mice lines carrying mutations in UCH-L1 gene have been made. A TAT-fusion
protein has been generated to delivery UCH-L1 into the brain. Recently, their research has demonstrated that a
specific point mutation in UCH-L1 can significantly attenuate stroke- or trauma- induced brain damage. In addition,
in vivo delivery of TAT-UCH-L1 protein is protective against stroke- and trauma- induced neuronal injury. Dr. Liu
is a member of Society for Neurosciences (SFN) and International Society for Cerebral Blood Flow and Metabolism
(ISCBFM), and he is an ad-hoc reviewer for some journals including APMIS, Cellular Physiology and Biochemistry,
Molecular Medicine Reports, and he also served as a reviewer for the international academic conference: Brain &
BrainPET -2017.
Ruth AnnStetler, PhD
Assistant Professor of Neurology
Dr. Stetler’s research has been focused on mechanisms supporting tissue protection against and
cellular recovery from cerebral ischemia. She has been actively pursuing the influence of DNA
repair in white matter recovery following ischemic injury. In addition, several other projects
are under development, including the role of mitochondrial dynamics in ischemic
neuroprotection. Major publications include the following:
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics
GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter and neurological function
after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567, doi:10.1073/pnas1606226113
Stetler RA, Leak RK, Jing Z, Hu X, Gao Y, Cao G, Chen J. The interplay between white matter, mitochondria and
neuroprotection. In: Vascular Mechanisms in CNS Trauma. Eds: Lo EH, Lok JM and Whalen M, Springer: New
York. 2014;539-554.
Stetler RA, Leak RK, Gan Y, Li P, Hu X, Jing Z, Chen J, Zigmond MJ, Gao Y. Preconditioning provides
neuroprotection in models of CNS disease: Paradigms and clinical significance. Progress in Neurobiology,
2014;114:58-83.
Stetler RA, Leak RK, Gao Y, Chen J. The dynamics of the mitochondrial organelle as a potential therapeutic target.
J Cereb Blood Flow Metab. 2013;33:22-32.
Stetler RA, Leak RK, Yin W, Zhang L, Wang S, Gao Y, Chen J. Mitochondrial biogenesis contributes to ischemic
neuroprotection afforded by LPS preconditioning. J Neurochem. 2012;123(Suppl. 2):125-137.
Stetler RA, Gao Y, Zhang L, Weng Z, Zhang F, Hu X, Wang S, Vosler, Cao G, Sun D, Graham SH, Chen J.
Phosphorylation of HS27 by Protein Kinase D is essential for mediating neuroprotection against ischemic neuronal
injury. J Neurosci. 2012;32(8):2667-2682.
Stetler RA, Gan Y, Zhang W, Liou AK, Gao Y, Cao G, Chen J. Heat shock proteins: Cellular and molecular
mechanisms in the CNS. Progress in Neurobiology, 2010;92(2):184-211.
Stetler RA, Gao Y, Zukin RS, Vosler PS, Zhang L, Zhang F, Cao G, Bennett MVL, Chen J. The
apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. PNAS. 2010;107(7):3204-3209.
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Dandan Sun, MD, PhD
Professor of Neurology
Dr. Sun’s laboratory is interested in understanding the role of ion transporter proteins (Na+-K+-
Cl- cotransporter, Na+/H+ exchanger, and Na+/Ca2+ exchangers) in ionic dysregulation and
neurodegeneration associated with stroke and hypoxic ischemic encephalopathy. In particular,
we study how changes of cytosolic ionic concentrations (Na+, H+, Ca2+) as well as organelle
Ca2+ (ER and mitochondria) cause nerve cell death and proinflammatory responses in ischemic
brains. With respect to Glioblastoma multiforme (GBM) brain tumor, we study how the ion
cotransporters function in regulating tumor tissue microenvironment and cell volume. These proteins are targets for
therapeutic intervention.
During the academic year July 2016 – June 2017, Dr. Sun’s laboratory made major research progress and published
the following scientific papers:
1. Y. Yin, G. Sun, E. Li, K. Kiselyov, Dandan Sun. ER stress and impaired autophagy flux in neuronal
degeneration and brain injury. Ageing Research Reviews 2016, pii: S1568-1637(16)30169-6. doi:
10.1016/j.arr.2016.08.008. 2. J. Zhang, G. Gao, G. Begum, J. Wang, A. R. Khanna, B. E. Shmukler, G. Daubner, P.Heros, P. Davies,
J. Varghese, M. I. H. Bhuiyan, J.J Duan, J. Zhang, D. Duran, S. L. Alper, Dandan Sun, S. J. Elledge,
D. R. Alessi, K. T. Kahle. Functional kinomics establishes a critical node of volume-sensitive cation-
Cl− cotransporter regulation in the mammalian brain. Scientific Reports, 2016, 6:35986. doi:
10.1038/srep35986
3. M. I. H Bhuiyan, S. Song, H. Yuan, G. Begum, J. Kofler, K. T Kahle, S-S Yang, S-H Lin, S. L Alper,
A. R Subramanya and Dandan Sun. WNK-Cab39-NKCC1 signaling increases the susceptibility to
ischemic brain damage in hypertensive rats. JCBFM. 2016, pii: 0271678X16675368. NIHMS 840430 4. Y. Yin, E. Li, G. Sun, H. Q. Yan, L. M. Foley, L. A. Andrzejczuk, I. Y. Attarwala, T. K. Hitchens, K.
Kiselyov, C. E. Dixon, Dandan Sun. Effects of DHA on hippocampal autophagy and lysosome
function after traumatic brain injury. Mol Neurobiol. 2017. NIHMS 864940
Kejie Yin, MD, PhD
Assistant Professor of Neurology
Dr. Kejie Yin has been an Assistant Professor in the Department of Neurology since September
2015. Dr. Kejie Yin earned his MD from Yangzhou University Medical College, MS in
Neuroanatomy from Nanjing Medical University, and PhD in Neurobiology from Shanghai
Medical University. After completing his postdoctoral training at College of Medicine University
of Saskatchewan in Canada, Dr Yin joined in the Department of Neurology in the Washington
University School of Medicine as a Research Associate and a Research Instructor. Dr. Yin was a
Research Assistant Professor in the University of Michigan before his recruitment to the University of Pittsburgh
School of Medicine.
As a principal investigator in the Pittsburgh Institute for Brain Disorders and Recovery (PIBDR), Dr. Yin’s research
interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural
dysfunction after ischemic stroke, traumatic brain injury and Alzheimer's disease by using state-of-the-art cell
biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal
approaches. His major research focuses on investigating the functional importance and molecular mechanisms of
non-coding RNAs (microRNAs, long non-coding RNAs) and Krüppel-like transcription factors in the
cerebrovascular endothelial pathophysiology (BBB disruption, Vascular and parenchymal inflammation,
Angiogenesis) following ischemic stroke and traumatic brain injury. Currently Dr. Yin’s research is supported by
two NIH R01 and one R21 grants.
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Dr. Yin teaches graduate students and postdoctoral fellows in the PIBDR and CNUP at the University of Pittsburgh
Medical Center. He also gives lectures at the departmental lecture or seminar series. He performs laboratory-based
research tutoring and teaching to Post-doctoral fellows, graduate students, and clinical fellows in his laboratory as
well.
In the coming year, Dr. Yin will continue to work on his NIH-funded basic and translational research programs
investigating mechanisms of neuroprotection and repair in the setting of stroke.
Feng Zhang, MD, PhD
Assistant Professor of Neurology
Pittsburgh Institute of Brain Disorders and Recovery
Dr. Zhang joined the faculty of Neurology in November of 2009. His research interest
focuses on experimental cerebral ischemia and neuroprotection using small molecular
proteins, chemical compounds or ischemic preconditioning. His projects include the
neuroprotective effects of synthetic triterpenoids, hypothermia, ischemic preconditioning
and omega-3 fatty acids, which are rich in fish oil. He is also interested in the mechanisms
responsible for the protection of these approaches, including various signaling pathways and antioxidative
enzymes. His recent researches focus on Nrf2 pathway in neuroprotection mediated ischemic preconditioning,
which is supported by a NIH R01 grant. Dr. Zhang serves as an editorial board member for the NS &
Neurological Disorders‐Drug Targets and Austin Journal of Cerebrovascular Disease & Stroke, and as ad-hoc
referee for a number of journals, including Neurobiology of Disease, CNS Neuroscience & Therapeutics, Brain
Research, Translational Stroke Research, Plos One, Journal of Visualized Experiments, Molecular
Neurobiology, Pharmacology, Neuroscience and Scientific Reports.
Michael Zigmond, PhD
Professor of Neurology
Pittsburgh Institute for Neurodegenerative Diseases
Over the past year Dr. Zigmond and his research team have continued their studies of cellular
and animal models to examine Parkinson's disease (PD) and aging. A major focus of the lab is
finding ways to arrest the motor decline associated with PD. They hypothesize that a loss of
trophic factor support is involved in these motor deficits and that this leads to a decline in the
activation of survival kinases such as ERK1/2 and Akt and a consequent deterioration of
dopaminergic signaling. Their evidence indicates that the expression of neurotrophic factors,
including GDNF and BDNF, can be enhanced by physical exercise and that this in turn can stimulate kinases and
reduces the vulnerability of dopamine to neurotoxins and to the effects of aging.
The Zigmond lab is also interested in the impact of stressors on the vulnerability of dopamine neurons to subsequent
cellular stress. These studies have involved both in vivo and in vitro models. For example, they have found in
preliminary studies that several stressors – including maternal separation, traumatic brain injury, and restraint stress
– can make rats more vulnerable to 6-hydroxydopamine. On the other hand, exposure to a subtoxic concentration of
6-hydroxydopamine, methamphetamine, or MG132 (an inhibitor of proteasomal function) greatly
reduced the vulnerability of dopaminergic cells to a subsequent challenge; a phenomenon termed “preconditioning.”
Indeed, exercise may reflect a type of in vivo preconditioning by virtue of the mild increase in cellular stress that it
provokes.
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Vascular Neurology
Tudor Jovin, MD
Associate Professor of Neurology and Neurosurgery
Division Chief, Vascular Neurology
Director, UPMC Center for Neuroendovascular Therapy
Director, UPMC Stroke Institute
Chair, UPMC Stroke System of Care
Dr. Jovin is an expert in interventional and non-interventional treatments for the entire spectrum
of cerebrovascular disorders, including ischemic hemorrhagic stroke, and is the leader of UPMC
Stroke Institute, one of the highest volume centers in the country.
He serves as principal investigator for the ongoing REVASCAT study, a randomized trial in Spain of endovascular
therapy versus medical therapy for stroke due to large artery occlusion within 8 hours, as well as principal
investigator for DAWN, a multicenter, international, randomized trial of endovascular therapy versus medical
therapy in the beyond 8-hour time window. He is a member of the executive/steering committee for several
multicenter national and international trials, and he is site principal investigator/co-investigator for several local or
multi-center clinical trials. He has published more than 150 articles in peer-reviewed journals or book chapters.
As the former UPMC Stroke Fellowship Program Director and UPMC Neurointerventional Fellowship Program
Director, positions he has held for over five years, Dr. Jovin has significant experience in mentoring young
neurologists or neurosurgeons who, in addition to acquiring the necessary clinical and procedural skills for
successful clinical practice, have authored numerous publications in leading peer-reviewed cerebrovascular disease
journals.
Dr. Jovin serves as president of the Society of Vascular and Interventional Neurology and serves on several other
committees or boards of national and international societies (American Academy of Neurology, American Society
of Neuroimaging, Society of Neurointerventional Surgery) and editorial boards of medical journals within his area
of expertise (Stroke, Journal of Neuroimaging). Dr. Jovin’s clinical and research activities are focused on the care
of patients with cerebrovascular disorders. Investigator/Co-investigator on several local or multi-center clinical
trials, he brings the experience to successfully design and carry out clinical studies. As the former UPMC Stroke
Fellowship Program Director and UPMC Neurointerventional Fellowship Program Director, positions he has held
for over 5 years Dr. Jovin has significant experience in mentoring young neurologists or neurosurgeons who in
addition to acquiring the necessary clinical and procedural skills for successful clinical practice have authored
numerous publications in leading peer-reviewed cerebrovascular disease journals.
Maxim Hammer, MD
Associate Professor of Neurology
Vice-Chairman, Clinical Affairs
Director, Inpatient Neurology
Director, Vascular Neurology Fellowship Program
Director, Neurosonology Laboratory
UPMC Presbyterian Hospital
Staff Stroke Neurologist, The Stroke Institute
UPMC Mercy Hospital
Director, Stroke Services
A graduate of Dartmouth College, Dr. Hammer did his Neurology Residency at the Cleveland Clinic, then his
Vascular Neurology Fellowship at UPMC under Dr. James Gebel. He joined the Neurology faculty in 2003. He is
Board certified in Neurology as well as in Vascular Neurology and is interested in clinical practice, clinical research
and teaching.
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Dr. Hammer has been the Director of Stroke services at UPMC Mercy Hospital since 2008, where he has overseen
the development of a busy inpatient stroke practice. The Stroke Program at Mercy has been given multiple awards
by the American Heart Association during the time of his directorship. He has also has helped develop the
department’s Stroke Clinic at UPMC Mercy. He founded and directs the department’s Neurosonology lab, which
provides outpatient services as well as inpatient services to UPMC Mercy and Presbyterian hospitals, using carotid
duplex and transcranial ultrasonography. Dr. Hammer continues to attend hospital service at UPMC Presbyterian,
Shadyside and Mercy, and contributes to providing telemedicine stroke services to multiple hospitals in and out of
the UPMC system.
Dr. Hammer’s research interests lie predominantly in novel approaches to acute stroke, and he has contributed to
national clinical research studies including SENTIS (Safety and Efficacy of NeuroFlo Technology for Ischemic
Stroke), for example, and has participated in multiple other industry sponsored as well as NIH sponsored clinical
trials. However, Dr. Hammer prefers mentoring medical students in their research endeavors, usually focused on
quality improvement, and many of these projects have blossomed into significant publications.
Dr. Hammer has been involved with teaching since joining the department, beginning with didactic and bedside
teaching of residents and fellows. Since 2009, he has been involved with teaching at the Medical School’s
Neuroscience course both as lecturer and preceptor and in 2013 was asked to join the course’s curriculum
development committee. Dr. Hammer has been part of the Neurology Residency Curriculum Development
committee since 2006. He has been the director of the department’s Vascular Neurology Fellowship program since
2012, having mentored three fellows per year since that time.
Dr. Hammer assumed administrational roles within the Department, starting in 2014, when he became the Director
of Inpatient Services, involving oversight of inpatient neurologic care at many UPMC hospitals. In 2015, he became
Vice Chairman of Clinical Affairs for the Department, and now oversees all aspects of inpatient and outpatient
clinical care. In 2015-16, he completed the Marshall W. Webster Physician Leadership Training Program and has
been accepted into the first class of the newly-created Katz-UPMC Executive MBA in Healthcare program.
Ashutosh Jadhav, MD, PhD
Assistant Professor of Neurology
UPMC Stroke Institute
UPMC Center for Neuro-endovascular Therapy
Director, Stroke Services, UPMC, Shadyside Campus and Mercy Campus
Associate Director, Vascular Neurology Fellowship Program
Director, StrokeNet Fellowship Program
Dr. Jadhav is Assistant Professor of Neurology and Neurosurgery. He completed his
undergraduate and graduate studies at Harvard University after which he completed his medical studies at Harvard
Medical School. He is dually trained in the medical and endovascular care of stroke patients. He is a member of
the UPMC Stroke Institute and Center for Neuro-endovascular Therapy where he has performed over 2000 neuro-
interventional procedures. He also services as director of stroke services at UPMC-Shadyside campus. He actively
participates in resident and fellow education with weekly lectures. His teaching efforts have been recognized twice
with the Neurology resident Faculty Teaching Award. Additionally, he services on the curriculum committee for
the Neurology residency and Vascular Neurology fellowship. He actively participates in nursing and EMS education
with monthly lectures. He serves on the UPMC Stroke Institute CME course planning committee. Dr. Jadhav is an
active member of several societies, including the American Stroke Association where he serves as an abstract grader
for the annual International Stroke Conference. As a member of the Society of
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Vascular and Interventional Neurology, Dr. Jadhav is a board member and an associate editor of the quarterly
newsletter. Additionally, Dr. Jadhav serves as a reviewer for several journals including: Neurology, Journal of
Neuro-Interventional Neurosurgery, Journal of Neuroimaging. He has published over 70 articles in peer-reviewed
journals or book chapters. He serves as a sub-investigator on over a dozen clinical trials and serves as local principal
investigator on six global clinical trials (ARISE II, Atlas, DAWN, Rhapsody, STRATIS and Trevo Registry). His
research interests focus on the natural history and management of cerebrovascular occlusive disease and
endovascular approaches to acute ischemic stroke.
Name: James R. McLaughlin D.O. FACP, FAAN, FAHA
Clinical Assistant Professor of Neurology
Dr. McLaughlin has been affiliated with the UPMC Neurology Department since October 2006
and a faculty member since January 2016. Completed a general internal medical residence at
Geisinger Medical Center in 1987 and a Neurology residency at St. Louis University in 1990.
He subsequently joined the medical staff at Franklin Regional Medical Center in 1990 and
started a Primary Stroke Care Program in 1995 which has continued to date. He is currently
board certified in general internal medicine, neurology, vascular neurology and clinical
neurophysiology.
Dr. McLaughlin is the medical director for the Primary Stroke Care Program, Clinical Neurophysiology Lab and
Telemedicine services at UPMC Northwest. He practices general neurology as well as subspecialty care in vascular
neurology and clinical neurophysiology for both the inpatient and outpatient department at UPMC Northwest.
During his tenure as medical director of the stroke program it has received JCH certification as a primary stroke care
center and multiple awards from the ASA/AHA for quality of stroke care. Previously a member of the American
Stoke and Heart Association Telemedicine Committee, he continues these efforts locally through UPMC Northwest
telemedicine and active involvement in EMS education and assessment of triage mechanisms in the community.
Dr. McLaughlin is also actively involved in educating nursing, radiology technician and medical students through
attendance at the inpatient bi-weekly multi-disciplinary stroke care meeting and as preceptor for nursing and medical
students in the office setting.
This past year through Dr. McLaughlin’s direction the hospital implemented a tele ophthalmology consult service
utilizing a digital retinography system in conjunction with the University Eye & Ear Institute. This will allow 24/7
availability for ophthalmologic emergencies and effective triage for both adult and pediatric patients.
In the coming year, we will continue to develop the program as described above and plan the development of an
inpatient tele neurology consult and rounding service in conjunction with UPMC Stroke institute and UPMC Hamot
Department of Neurology which will ensure consistent care and appropriate triage of patients in Dr. McLaughlin’s
absence. Through Dr. McLaughlin’s oversight, we are currently proceeding with development of an ICU tele consult
service in conjunction with Dr. Al-Khafaji and the Department of Critical Care Medicine. With Dr. McLaughlin’s
supervision, the Emergency Room EMS representative and an Emergency Room stroke nurse representative are
currently educating local EMS crews and coordinating a follow-up assessment of the deficiencies identified in the
rural community EMS poster presented at the International Stroke Conference 2017.
There is ongoing discussion and planning to ultimately implement a field telemedicine triage plan for stroke patients
regionally.
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Vivek Reddy, MD
Assistant Professor of Neurology
Dr. Reddy is involved in a variety of clinical and educational activities as part of the department
of neurology. His clinical work involves outpatient services, focusing on the continuing care and
evaluation of patients with cerebrovascular disease. He also is very involved in the inpatient
clinical stroke service, focusing on standardization of clinical practice and approach to stroke
care. He has been very involved in the creation and enhancement of
stroke order sets and protocols at UPMC Presbyterian and UPMC Shadyside, which have served
as the basis of order sets for other UPMC hospitals.
In addition to his clinical work, Dr. Reddy is the Chief Medical Information Officer, Physician and Hospital Services.
His role extends across all the UPMC facilities and involves guiding the direction, improving utilization of electronic
medical records to improve quality of care. He has been involved in several implementations of electronic medical
records across the system.
Dr. Reddy provides educational supervision to residents and medical students and gives several lectures to medical
students and residents during the academic year.
Mareclo Rocha, MD, PhD
Assistant Professor of Neurology
Dr. Rocha was awarded an UPP Foundation Research Grant for the study of
mitochondrial based biomarker development in acute strokes due to large vessel
occlusion during the 2016-2017 academic year. This funding has been renewed for the
2017 – 2018. The plan is to generate preliminary data for submission of career
development grants from professional organizations (AHA, AAN), private foundations
(Welcome Borrows Fund) and NIH K-award applications in the upcoming grant
cycles.
Dr. Rocha published two first author articles in the two of the widely-read journals in our field (Rocha M
and Jovin TG, Stroke 2017 and Rocha M et al., Journal of Neurointerventional Surgery, in press).
Dr. Rocha submitted Research Abstract to the International Stroke Conference to take place in January
2018 (AHA): Rocha M, Desai S, Jadhav A and Jovin T. Distribution and Incidence of Fast Versus Slow
Progressors of Infarct Growth in Large Vessel Occlusion Stroke. This abstract will lead to the publication of
another first author publication in the next academic year. It also will form the basis for two other related
clinical research projects which I expect will lead to additional first or last author manuscripts.
Dr. Rocha renewed a University of Pittsburgh IRB Study: Characterization of Infarct Growth Rate in
Acute Ischemic Stroke due to Large Vessel Occlusion. This study will lead to the publication of
important clinical retrospective studies as a continuation of work on the characterization of different sub-
types of ischemic stroke that will pave the way for translational research in future potential
neuroprotective therapies in stroke.
Dr. Rocha lectured in the multiple academic and community health care settings:
• Secondary Stroke Prevention. Neurology Residency Boot Camp. July 2017, University of
Pittsburgh Medical Center.
• Malignancy and Ischemic Stroke. UPMC Northwest Stroke Symposium. May 2017,
Franklin, PA.
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• Pathophysiology of Acute Cerebral Large Vessel Occlusion: Emerging Trends. Grand
Rounds Lecture, Department of Neurology, University of Pittsburgh Medical Center,
September 2016, Pittsburgh, PA.
• Drugs of Abuse and Stroke. UPMC Telestroke International Lecture, July 2016, Pittsburgh,
PA and Xuanwu Hospital, Beijing, China.
Matthew Starr, MD
Assistant Professor of Neurology
Dr. Starr created and maintains a database of basilar artery occlusion patients treated with
intraarterial therapy. Information from his database was used in collaboration with
physicians at Emory University on a paper published this year. Dr. Starr is working with
Dr. Samir Saba in the department of Cardiology on some projects dealing with
cardioembolic stroke, paroxysmal atrial fibrillation and left atrial appendage morphology.
Dr. Starr created a database to review efficacy of loop recorders in detecting occult
paroxysmal atrial fibrillation in our stroke patients. He is collaborating with Dr. Kormos in CT surgery
department on a project about LVAD and stroke. Dr. Starr was also the PI of the PRISMS trial looking at IV
TPA for minor strokes and we were the 5th leading enrollers in the study. He is the medical management
physician for the CREST 2 study and the blinded site PI for Actissima stem cell trial. He will be the PI in an
upcoming StrokeNet study managing Embolic Stroke of Unknown Source. Dr. Starr is a sub-I on multiple
stroke clinical trials.
Lawrence R. Wechsler, MD
Chair, Department of Neurology
Henry B. Higman Professor of Neurology / Neurosurgery
Vice President of Telemedicine, PSD
Lawrence Wechsler, MD, Professor of Neurology at the University of Pittsburgh School of
Medicine is Henry B. Higman Professor and Chair of the Department of Neurology. He also
serves as Vice President for Telemedicine in the Physician Services Division.
Dr. Wechsler’s interests include acute stroke therapy, imaging and telemedicine. He is a leader in the field of
vascular neurology and has participated on steering committees, advisory boards, or as a DSMB member for
numerous national and international clinical trials that have impacted practice and improved outcomes for stroke
survivors. Dr. Wechsler along with Dr. Kondziolka of the Department of Neurosurgery spearheaded the first clinical
trials of cellular therapy for treatment of stroke. Dr. Wechsler holds memberships in several organizations, including
the American Neurological Association, American Stroke Association, American Society of Neuroimaging and the
American Academy of Neurology. He is past Chair of the Stroke Systems Work Group at the American Academy
of Neurology and past President of the American Society of Neuroimaging. Dr. Wechsler has authored or co-
authored numerous articles related to stroke and stroke therapy.
Dr. Wechsler developed and implemented the telemedicine program for acute stroke assessment at UPMC. He was
an early proponent of telestroke program development, and currently oversees a network of 21 hospitals in the
western Pennsylvania area. Since the inception of the Telestroke service at UPMC, over 2,013 stroke patients have
been evaluated with outcomes the same as expected for patients treated face-to-face. In addition to Telestroke,
UPMC has expanded telemedicine to 35 specialty services lines across multiple locations and has active Teleconsult
centers across 3 locations in Western Pennsylvania where patients can be scheduled to have a virtual visit with a
specialist from Pittsburgh.
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St. Margaret/McKeesport
Stuart Silverman, MS, MD, FAAN
Clinical Associate Professor of Neurology
Stuart Silverman, MS, MD, FAAN, is board-certified in neurology and a Fellow of the American
Academy of Neurology. He has special interests and more than 25 years of experience in
multiple sclerosis, spinal diseases, and neuroimaging. He sees inpatients and outpatients for all
adult clinical neurology.
Dr. Silverman received his medical degree from Georgetown University School of Medicine in
Washington, D.C. He then completed his neurology residency at Georgetown University
Hospital.
Through the year I will continue to teach residents at both UPMC St. Margaret Hospital and UPMC McKeesport
Hospital to insure our consult service. I will also continue our MS Clinic and increase our neuroimaging practice.
Edward Mistler, MD
Clinical Assistant Professor of Neurology
Dr. Edward Mistler joined the Department of Neurology on January 1, 2014. Prior to joining,
he was in private practice for 10 years in Pittsburgh. He is primarily a clinical neurologist who
sees patients at 3 offices throughout Allegheny County; West Mifflin, Mckeesport and
Aspinwall.
Dr. Mistler has a special interest in NCS/EMG and botulinum toxin administration which he
performs at all offices. He serves on the Medical Executive Council for Mckeesport Hospital.
He is also responsible for all neurology consults at UPMC-Mckeesport Hospital and is the Stroke Medical Director
for UPMC Mckeesport. Duties as Stroke Director include a monthly meeting with the interdisciplinary team, and
weekly meeting with the clinical coordinator. UPMC Mckeesport Hospital is accredited by JACHO as a Primary
Stroke Center. Dr. Mistler also gave a presentation at UPMC Mckeesport Hospital Nursing Education lecture series
on June 13, 2017.
Dr. Mistler is responsible for neurological education for the medicine and family practice residents at Mckeesport
Hospital, and serves as the Neurologic Education director. This involves a 5-lecture series for the residents and 1
grand rounds per year of didactic lectures. He gave one grand rounds lecture on Stroke at Mckeesport Hospital
August 16, 2016. There are also small group sessions at least once per month and at least one resident from each
specialty is on the Neurology team each month and is directly supervised by Dr. Mistler. Dr. Mistler also supervises
one St. Margaret’s Family Practice Resident every Wednesday in the outpatient setting.
In addition to his outpatient duties and UPMC Mckeesport Hospital coverage, Dr. Mistler provides inpatient care to
patients at UPMC St. Margarets Hospital at least once per week. He covers both hospitals one week per month on
call.
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Northshore – Hamot Erie
James DeMatteis, MD
Division Chief of Neurology - Hamot
Medical Director Stroke Center – Hamot
Dr. DeMatteis specializes in stroke and neurovascular disease, Parkinson's disease, and
neurological rehabilitation. He is presently a staff neurologist at UPMC Hamot (formerly
known as Hamot Medical Center). He is the medical director for neuro rehabilitation at
HealthSouth Rehabilitation Hospital, Erie Pennsylvania. He is very actively involved in
education and patient care. He has won several awards; the one most cherished is the best
teacher award. He is also very actively involved in education. He is the annual course director
for Hamot Neurosciences. He has several board certifications in Neurology, Internal Medicine, Neurological
Rehabilitation, EMG, and Neurovasculaar Disease.
Dr. DeMatteis has been on the medical staff at UPMC Hamot since July 1984. In the past, he has been involved in
several phase 3 drug studies. To name a few, these have been Avail, Capture 2, Optima, Atlantis stroke study, and
ProFESS study. Presently he is involved in MARISS and NAVIGATE ESUS.
Jeffrey J. Esper, DO, MS (Med Ed)
Professor of Internal Medicine/Neurology, LECOM
UPMC Hamot Neurology Residency Program Director
UPMC Hamot Osteopathic Director of Medical Education
Dr. Esper is the neurology residency director at UPMC Hamot where he supervises 9 neurology
residents. He also serves as an instructor for the residents of emergency medicine at UPMC
Hamot and for the psychiatry, internal medicine and ophthalmology residents from Millcreek
Community Hospital. He is also the director of the EMG laboratory at UPMC Hamot. He has
successfully completed a Master’s degree in Health Services Administration in
May of 2017. He also serves as the director of the Muscular Dystrophy Clinic in Erie, Pa. Dr. Esper is clinical
course director for the neurosensory system at LECOM. This system runs from March until May each year where
Dr. Esper gives 25 lecture hours each year to the medical students. This duty also requires writing new test questions
for each lecture. Dr. Esper also develops case scenarios and differential diagnosis exercises for the students. Dr.
Esper teaches medical students in the classroom setting and in the clinical setting, both office and hospital settings.
Dr. Esper continues to serve as LECOM curriculum committee chairman. Dr. Esper also is an active participant and
examiner in the ACONP oral board certifying examinations each spring. He has participated in research projects
and case study posters and publications with the neurology residents. He is coauthoring, with a couple of the
neurology residents, a neurology related chapter in a neurosurgery textbook.
Erica Grazioli, DO, M.S. Med Ed
Neurologist
Director, UPMC Hamot MS Fellowship Program
Director, UPMC Hamot MS Center of Excellence
Medical Director UPMC Hamot Infusion Center
Dr. Grazioli is involved clinically in the care of patients with multiple sclerosis and sleep
disorders and is the director of the UPMC Hamot Multiple Sclerosis Center. The UPMC
Hamot Multiple Sclerosis Center is recognized as a Comprehensive Care Center by the
National Multiple Sclerosis Society and, as part of this relationship, a weekly
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multidisciplinary shared clinic is conducted at UPMC Northshore Neurology with representation from the local
National Multiple Sclerosis Society. Dr. Grazioli also completed the book chapter entitled Temporal and Clinical
Course of Multiple Sclerosis in Primer on Multiple Sclerosis, Second Edition, Oxford University Press, 2016.
Dr. Grazioli is active in medical education. Dr. Grazioli continues to regularly supervise neurology residents during
a one month multiple sclerosis rotation during the fourth postgraduate year as well and on EMG rotation. She is
active in resident didactics, lecturing monthly on sleep medicine and multiple sclerosis topics. She is also a lecturer
on multiple sclerosis for the Lake Erie College of Osteopathic Medicine. Additionally, Dr. Grazioli provides regular
“lunch and learn” seminars for the neurology advanced practice providers.
Daniel Kinem, DO
Chief of the Division of Neurology, UPMC Hamot
Neurohospitalist, UPMC Hamot
Medical Director, UPMC Hamot Neurophysiology Department
Dr. Kinem serves as the Chief of the Division of Neurology for UPMC Hamot. He also serves
as the lead neurohospitalist, Medical Director of the Neurophysiology Department and of the
UPMC Hamot Neurology floor. His duties include representing the neurology division in
hospital affairs, credentialing of physicians and other health care providers, peer review and
quality assurance for the neurology division, and the development and improvement of the acute stroke program.
As lead neurohospitalist, Dr. Kinem is charged with scheduling and coordinating hospital coverage.
Very active in teaching, Dr. Kinem directly mentors medical students, ED, IM, and psychology residents. In
addition, he has significant training and educational responsibilities for the UPMC Hamot Neurology Residency
Program. Dr. Kinem is also active in stroke rehabilitation as an admitting and consulting physician at Health South
Rehabilitation Hospital.
Lazarus Mayoglou, DO
Medical Director of Epilepsy Services in Neurology
Dr. Mayoglou has been working to set up a continuous ICU-EEG monitoring program, as well as
an epilepsy monitoring unit. Lecturing Neurology residents
Dimitrios Nacopoulos
Clinical Assistant Professor
Twice monthly Movement Disorders lectures for UPMC-Hamot Neurology residents and
rotating medical students has been part of the curriculum and will continue to grow, with plans
to incorporate quarterly video series for teaching purposes to trainees and faculty. Recently
appointed as assistant program director for the UPMC-Hamot Neurology residency program with
plans to expand teaching opportunities for faculty as well as incorporate new teaching strategies
for the residency program, such as clinical examination teaching. Working with program director
in identifying gaps in transition to ACGME accredited program. Providing mentorship to rotating medical students
through outpatient clinical experience. Continuing to grow the presence of UPMC’s neurology division through
public relations and events in the Parkinson’s community of Northwest Pennsylvania and the greater Tri-State
region. Collaboration with Dr. R. Mark Richardson, MD, PhD – neurosurgery UPMC-Presbyterian, in
multidisciplinary DBS clinic with plans on collecting data for future research.
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Jingzi Shang, MD
Neurologist
Director UPMC Sleep Disorder Center
Dr. Shang’s practice is primarily focused on caring for patients with sleep disorders and
headache. In addition she cares for patients general neurological problems as well. She does
Botox injection for chronic migraine patient. Dr. Shang also read polysomnogram and
electroencephalogram at UPMC Hamot – Erie.
Michelle Stevens, DO
Neurologist
Co-Director, MDA Clinic of Northwest PA Northshore Practices
Dr. Stevens is co-director of the Muscular Dystrophy Association Clinic of NWPA and
specializes in Neuromuscular disorders. She primarily sees patients with myasthenia gravis,
muscle diseases, and peripheral nerve disorders. She also has an interest in headache and
general neurology. She performs EMG studies in the UPMC Hamot EMG laboratory. Dr.
Stevens is active in Neurology resident and LECOM medical student education, mentoring
students on a nearly daily basis in the clinic and EMG lab.
Heritage Valley – UPMC
Erin Canale, MD
Clinical Assistant Professor of Neurology
During the academic year 2016 – 2017, Dr. Canale joined the providers at Heritage Valley-
UPMC Multispecialty Group Inc. in Monaca, Pennsylvania. This busy practice in Beaver County
was acquired by UPMC in 2015 and is staffed by 2 physicians and 2 physician assistants at a
stand-alone outpatient facility. Providers see all aspects of outpatient general neurology. Dr.
Canale also sees patients one day per week in Calcutta, OH in a neurologically underserved area.
In addition to general neurology outpatient responsibilities, Dr. Canale participates in reading EEGs for the
Continuous (ICU/CC) EEG Service based out of UPMC Presbyterian Shadyside, as well as reading outpatient EEGs
for Heritage Valley Beaver.
During the coming academic year, Dr. Canale will continue active clinical duties including teaching residents and
fellows in EEG.
Arthur R. Sonberg, MD
Clinical Assistant Professor of Neurology
During the academic year 2016-17, Dr. Sonberg continued to provide outpatient care at the
Heritage Valley UPMC Multispecialty Group facility in Monaca, PA. The facility serves the
Beaver County and surrounding areas as well as drawing patients from Ohio, West Virginia and
more distant areas of Pennsylvania. He has continued providing EEG and EMG services at
Heritage Valley Beaver. Dr. Sonberg also supervises the Monaca office, overseeing two
physician assistants and collaborating with the other office neurologists (as well as covering her
portion of the practice during maternity leave).
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Dr. Sonberg’s plans for the comoing 2017-18 timeframe include continuing practice in the Monaca/Beaver County
area and to continue working on a book which he would like to have published within the next few years. He
anticipates some additional pressure from the local practitioners for seeing more patients due to the impending
retirement of one of the other area neurologists who has been in practice in that area for many years.
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Study Sections and Advisory Committee Memberships
Anto Bagic, MD, PhD
Advisory Committee
Coordinator, American Epilepsy Society (AES) MEG SIG
Coordinator, American Clinical Neurophysiology Society (ACNS) NEG SIG
Member, Annual Meeting Program Committee, ACNS
Executive Committee Member, International Society for the Advancement of Clinical MEG
Board Member, National Association of Epilepsy Centers (NAEC)
Palatucci Advocacy Leadership Forum, American Academy of Neurology
AES Epilepsy Fellowship Program Director’s Committee
The German Federal Ministry of Education and Research and the ERA-NET NEURON (the NEURON Joint
Call Secretariat) the funding initiative “European Research Projects on Neurodevelopmental Disorders
Maria Baldwin, MD
Advisory Committee
Epilepsy Task Force (UPMC) – committee member assisting in development of status guidelines for the
hospital
Sarah B. Berman, MD, PhD
Study Section/Grant review
Parkinson Disease Foundation 2014-Present
United Mitochondrial Disease Foundation
Advisory Committees
Medical Advisory Board, Parkinson Foundation of Western Pennsylvania
Member, Outreach Program Committee, Parkinson Foundation of Western PA
Member, Advisory/Admissions/Steering Committees, Physician Scientist Training Program, UPSOM
Medicine
Member, Steering Committee, Neuroscience Area of Concentration, UPSOM
Member, Admissions/Recruiting Committee, Medical Scientist Trainign program/Center for Neuroscience at
UPSOM
Ad hoc interviewer, faculty recruitment, Department of Neurology UPMC
Edward Burton, MD, DPhil, FRCP
Advisory Committee
Cure PSP
Neil Busis, MD
Advisory Committees
UPMC
UPMC Patient Education Governance Committee
System-Wide Neurodiagnostic Committee
Data Governance Community
Data In/Data Out Workgroup
80
University of Pittsuburgh Physicians
Physician Services Division (PSD) Physician Clinical Quality Leadership Committee
Helping to pilot an educational module on physician communication to enhance patient satisfaction and
improve physician’s Press Ganey scores
UPMC Health Plan
UPMC Health Plan Specialty Care Work Group
UPMC Shadyside
Total Quality and Patient Safety Committee
Credentials Committee
UPMC Enterprises
Clinical Advisor to UPMC Enterprises
Department of Neurology
Chair, Value-Based Reimbursement Committee
Director, Neurodiagnostic Laboratory, UPMC Shadyside
Chief, Section of Neurology, Division of Medicine, UPMC Shadyside
Executive Committee, UPP Department of Neurology and Department of Neurology
Reviewer of Press Ganey data for outpatient services for UPP neurologists at UPMC Shadyside
Reviewer of HCAHPS and other Crimson data for UP neurologists performing inpatient services at UPMC
Presbyterian Shadyside
Planning Committee for 2nd Annual Neurology for the Medical Practioner Conference
UPP Department of Neurology Incentive Plan Committee
Leading Department of Neurology quality improvement project to decrease venous thromboembolism rates
on neurology inpatient services
Franca Cambi, MD, PhD
Advisory Committees
Scientific Advisory Board of the PMD Foundation
Guodong Cao, PhD
Study Sections
American Heart Association study section – IRG
Jun Chen, MD
Study Sections
VA RCS/Promotion Committee
Regular Member, NIH BINP Study Section
Ad hoc Reviewer: NIH Special Emphasis Review Panels; NIH Program Project Special Review
Panels; Department of Veterans Affairs Merit Review
Advisory Committees
Member, Board of Directors, International Society of Cerebral Blood Flow and Metabolism
Chair of the Membership Committee, International Society of Cerebral Blood Flow and Metabolism
University of Pittsburgh Department of Neurology, Recruitment Committee
Scientific Committee, Pittsburgh VA Health Care System
Program Committee, International Stroke Conference, American Heart Association
Steering Committee, American Heart Association Stroke Consul
81
Paula R. Clemens, MD
Study Sections
NIAMS Arthritis and Musculoskeletal and Skin Diseases Clinical Trials (AMSC) Review Committee
Advisory Committees
External
Member, Scientific Advisory Committee, NIH-sponsored National Registry for Myotonic Dystrophy and
Facioscapulohumeral Muscular Dystrophy Patients and Family
Chair, CINRG Publications Committee
Medical Director, Cooperative International Neuromuscular Research Group (CINRG)
Member, External Training Committee for the Ohio State University Muscle Group Training Program
Consultant, Reveragen
Member, Scientific Advisory Board for U01: Development of Novel Upper Extremity Outcome
Measures Using 3D-Vision Technology; PI: Jay Han, University of California Davis
Member, Pfizer DSMB
Member, North American Pompe Registry Board
Member, NIAMS DSMB University of Pittsburgh School of Medicine
Member, Molecular Genetics and Developmental Biology Graduate Training Program
Member, Cellular and Molecular Pathology Graduate Training Program
Member, MSTP and PSTP Student Advisory Committee, University of Pittsburgh
Member, PSTP Student Advisory Committee
Department of Neurology
Member, Executive Committee, Department of Neurology
Member, Neurology Faculty Promotions Committee, University of Pittsburgh
Co-Chair, Neurology Grand Rounds Committee
James DeMatteis, MD, FACP, FAAN
Advisory Committees
Education Committee for American Society of Neuro Rehabilitation
John Doyle, MD
Advisory Committees
Milestones Committee, University of Pittsburgh Department of Neurology
Jan Drappatz, MD
Study Section -
Neuro-Oncology Section, Alliance for Clinical Trials in Oncology, Committee member
Neuro-Oncology Task Force Development of Neuro-Oncology Pathways for high grade Glioma patients at
UPMC
ViaOncology, Neuro-Oncology Pathway Development, Brain Committee Chair
Advisory Committee
University of Pittsburgh
Committee Member, Neuro-Oncology Task Force, University of Pittsburgh
Internal Review Board, University of Pittsburgh
82
Data Safety Management Committee, University of Pittsburgh
Institutional Review Board
UPMC Neuro-Oncology Pathway Committee
Other
American Academy of Neurology
Alliance for Clinical Trials in Oncology – Neuro-Oncology Commmittee
American Association for Cancer Research
Charter member – BRAIN
Charter member – International Meningioma Society
International Primary CNS Lymphoma Collaborative Group
Society for Neuro-Oncology
Jeffrey Esper, DO, MS (Med Ed)
Advisory Committee
Committee on Medicine-Neurology, Bureau of Osteopathic Medicine and Surgery for POMA
Kathy Gardner, MD
Advisory Committees
Children’s Hospital of Pittsburgh
Co-Director, Neurofibromatosis Clinic
Adult Neurologist for the Tuberous Sclerosis Clinic
Pittsburgh
Advisor and board member, local Neurofibromatosis Clinics Association
REiNS (Response evaluation in neurofibromatosis and schwannomatosis) PRO Committee member
Gena Ghearing, MD
Advisory Committees
Clinical Neurophysiology Fellowship Committee
Neurology Residency Selection Committee
Residency Curriculum Committee
Clinical Competency Committee
Women in Neurology, University of Pittsburgh
Neurocritical Care Fellowship Selection Committee
American Clinical Neurophysiology Society Resident and Fellow Education
Graduate Medical Education Committee
Steven H. Graham, MD, PhD
Advisory Committees
University of Pittsburgh School of Medicine
Chair, Promotions Committee, Department of Neurology
Member, Executive Committee, Neurology Department
Department of Veterans Affairs
Member, VA VISN 4 Research Roundtable
Member, VA VISN 4 Academic Affairs Committee
Member, VA Pittsburgh Healthcare System, Medical Executive Board
Member, VA Pittsburgh Healthcare System, Executive Leadership Board
Treasurer, Veterans Research Foundation of Pittsburgh Board of Directors GRECC Director’s Association
83
Erica Grazioli, DO
Advisory Committees
Clinical Advisory Committee, National MS Society, Allegheny Chapter
J. Timothy Greenamyre, MD, PhD
Advisory Boards
National Advisory Boards
Member, Scientific Advisory Board, Parkinson’s Action Network
Member, Scientific Advisory Board, Cure Parkinson’s Foundation
Member, Scientific Advisory Board, Parkinson’s Disease Foundation
Executive Advisory Committee, Parkinson’s Disease Foundation
Member, Advisory Board, C. Mondino Institute of Neurology, Pavia, Italy
Member, Scientific Advisory Board, American Parkinson Disease Association
Member, Executive SAB, Michael J. Fox Foundation
Member, Neuroscience Therapeutic Area Scienfic Advisory Panel (TASAP), Pfizer
University of Pittsburgh
Co-Director, Huntington’s Disease Society of America Center of Excellence
School of Medicine MSTP Steering Committee
School of Medicine Committee for Tenured Faculty Promotions and Appointments (TFPA)
School of Medicine Health Sciences Research Advisory Committee
Department of Neurology, Executive Committee
Department of Neurology, Promotions Committee
Department of Neurology, Recruitment Committee
Max Hammer, MD
Advisory Committees
Member, Vascular Neurology Residency Program Interview Committee, Department of Neurology
Member, Residency Task Force Committee, Department of Neurology
Member, Professional Practice Evaluation Committee, Mercy Hospital
Member, Telestroke Executive Council
Member, Stroke Task Force Committee
Director, UPP Neurology Inpatient Services
Director of Stroke Services, UPMC Mercy Hospital and Shadyside Hospital
Director of Neurosonology Laboratory, Department of Neurology
Teresa Hastings, PhD
Advisory Committees
MSTP Steering Committee
MSTP/CNUP Admissions/Recruitment Committees
MSTP Program Evaluation Committee
University Council on Graduate Study
Promotions Committee - Department of Neurology
Tenure Stream Review Committee - Department of Neurology
Steering Committee, NIH/NIMH Institutional Predoctoral Training Grant
Executive Committee for PIND
84
Rock Heyman, MD
Advisory Committees
National Committees
National Multiple Sclerosis Society
Clinical Affiliations Committee
Medical Advisory Board, Executive Committee
National Council of Clinical Advisory Committee (CAC), Chairman
Member, Consortium of Multiple Sclerosis Centers
National Multiple Sclerosis Society, Keystone Chapter
Keystone Chapter Board of Trustees, executive committee
Chairman, Regional Clinical Advisory Committee, Chairman
University and School of Medicine Committees
UPMC Committees
Member, Epicare Record Implementation, Physician Leader
Director, Multiple Sclerosis Center
University of Pittsburgh School of Medicine
Member, Executive Committee, Neurology Department
Chief, Division of Neuroimmunology
Houman Homayoun, MD
Advisory Committee
Neurology Committee Member, MKSAP18, American College of Physicians
Xiaoming Hu, MD
Study Section
American Heart Association, Brain 3 study section
Milos Ikonomovic, MD
Study Section
NIH/CSR Brain Injury and Neruovascular Pathologies (BINP) Study Section, 2017/06
VA 2017/05 RRDI Brain Injury, TBI & Stroke, Special Emphasis Panel
VA RR&D Small Projects in Rehabilitation Research (SPiRE)
ZNS1 SRB-C(02), NINDS Special Emphasis Panel, November 2016
Ashutosh Jadhav, MD, PhD
Advisory Committees
Chairman, Vascular Neurology Fellowship Clinical Competency Committee
Member, University of Pittsburgh Neurology Residency Curriculum Committee
Member, Neurovascular & Neurocritical Care Conference Planning Committee
Member, UPMC Cerebrovascular Strategic Planning Committee
Society for Vascular and Interventional Neurology, BSLS committee
Society for Vascular and Interventional Neurology, Registry committee
85
Samay Jain, MD
Advisory Committees
National Organizations
Member, Parkinson Study Group, Other Non-motor Features Working Group
Member, Cardiovascular Health Study Neurology Working Group
University of Pittsburgh School of Medicine
Ad hoc Interviewer for Resident and Faculty Recruits
UPMC Institutional Review Board
Ruchira Menka Jha, MD
Advisory Committees
Neurocritial Care Team Coordination Committee
Neurocritical Care Fellowship Recruitment/Interview Committee
Neurology Vascular/Stroke Fellowship Recruitment and Interview Committee
Tudor Jovin, MD
Study Sections
Basilar Occlusion Chinese Endovascular Stroke (BAOCHE) Study – Co-PI
Member: Executive committee, Randomized Trial Comparing Transfer to the Closest Local Stroke Center vs.
Direct Transfer to Endovascualr Stroke Center of Acute Stroke Patients with Suspected Large Vessel
Occlusion in the Catalan Territory (RACECAT) Study
Chair: Neuroendovascular Surgery Advisory Council (NESAC), Committee on Advance Subspecialty Training
(CAST) Society of Neruological Surgeons
Advisory Committees
Founding Board Member, Society of Vascular and Interventional Neurology
Board of Directors Member, American Society of Neuroimaging
Executive Committee, IMS 3
SWIFT PRIME, Steering Committee
Carotid Revascularization Endarterectomy vs. Stent 2(CREST 2) trial, Interventional Credentialing Committee
ESCAPE, Steering Committee
Covidien Vascular, Global Advisory Board
Executive Committee, American Academy of Neurology, Interventional Neurology Section
American Heart Association, Board of Directors
NIH Stroke Trial Network, Interventional Advisory Committee
Chair: Neuroendovascular Surgery Advisory Council (NESAC), Committee on Advance Subspecialty Training
(CAST) Society of Neruological Surgeons
Robert Kaniecki, MD
Study Sections
American Academy of Neurology, Head and Facial Pain Section
American Headache Society, Refractory Headache Section
86
Advisory Committees
Chairman, Department of Neurology Scientific Review Committee
Member, Executive Committee, Department of Neurology
Member, Department of Neurology Residency Selection Committee
Member, Department of Neurology Quality Improvement Committee
Member, Department of Neurology Compensation Committee
Member, Neurology Value-Based Reimbursement Committee
Daniel Kinem, DO
Advisory Committees
University of Pittsburgh Medical Center Hamot
Member, Stroke Process Committee
Member, Ethics Committee
Laurie Knepper, MD
Advisory Committees
University of Pittsburgh and Medical School
Chair, Imaging Task Force UPSOM Curriculum Committee
Director of Neurology Clerkship Curriculum Committee
Women in Neurology Core Group, Department of Neurology
Curriculum Committee
Retention Committee
Promotions Committee
Child Neurology Clinical Competency Committee
Neurology Resident Milestone Committee
David Lacomis, MD
Advisory Committees
National Advisory Boards
Member, Scientific Advisory Board, Myasthenia Gravis Foundation of America
Member, North East Amyotrophic Lateral Sclerosis Consortium (NEALS)
Member, NEALS, cIRB MCTA Site Selection Metrics Committee
Member, ALS Research Group
University of Pittsburgh Physicians
Member, Epicare Oversight Committee, Neurology Department
Member, Executive Committee, Neurology Department
Member, Incentive Committee, Neurology Department
University of Pittsburgh School of Medicine
Member, Promotions Committee, Neurology Department
Erek Lam, MD
Advisory Committees
Stroke Certification Physician Liaison and Inpatient Stroke Quality, UPMC Passavant
87
Frank Lieberman, MD
Advisory Committees
Vice Chair, IRB (Oncology/Neuroscience)
University of Pittsburgh School of Medicine
Member, Bioethics Committee, UPMC Shadyside
Member, Protocol Initiation Committee, Scientific Review Committee (SRC) for Neuro-Radiology,
Member, Oncology Quality Improvement Council, University of Pittsburgh Cancer Institute
Oscar Lopez, MD
Study Sections
NIH, National Institute of Neurological Disorders and Stroke Special Emphasis Panel: ZNS1-SRB-G(68)
Advisory Committees
University of Pittsburgh School of Medicine
Department of Neurology Scientific Committee
Department of Psychiatry Scientific Committee
UPPA Credentialing Committee
Lewy Body Dementia Association, Scientific Advisory Committee
Working Group for the American Academy of Neurology Guidelines for the Diagnosis of
Mild Cognitive Impairment
Geriatric Research Education and Clinical Center (GRECC) Advisory Committee. VA Pittsburgh Healthcare
System, Pittsburgh, PA
National Heart, Lung, and Blood Institute (NHLBI): Consultant and Member of the Atherosclerosis Risk in
Communities Studies (ARIC) Monitor Board, Bethesda, MD
Cardiovascular Health Study Publications & Presentations Committee. National Heart, Lung and Blood
Institute (NHLBI).
Angela Lu, MD
Advisory Committee
Medical Student Neurology Clerkship Curriculum Committee
Neurology Resident Curriculum Committee
James McLaughlin, DO
Advisory Committees
ICU Committee
Physician Recuritment Committee
Quality Improvement Committee
UPMC Telemedicine Oversight Committee
UPMC Stroke QA Committee – System wide
Bradley Molyneaux, MD, PhD
Advisory Committees
Critical Care Medicine Fellowship selection interviews, University of Pittsburgh
Stroke Fellowship selection interviews, University of Pittsburgh Department of Neurology
Neurocritical Care Society – Annual meeting abstract reviewer and scientific program committee member
88
Ajitesh Ojha, MD
Advisory Committees
Neurology Rotation Curriculum Committee – UPMC
Neurology Curriculum Committee – UPC
Neurology Residency Selection Committee
Neurology Medical Student Education Committee
Jullie Pan, MD, PhD
Study Sections
NIH CSR Chartered member, Medical Imaging Study Section 2012-2016
Araya Puwanant, MD –
Study Sections
Advisory Committee for the NINDS NeuroNEXT clinical Research Site
Medical and Scientific Advisory Board for the Myasthenia Gravis Foundation of America
Marcelo Rocha, MD, PhD
Study Section
2016-17 participated in multi-disciplinary task force focused to reducing length of stay in patients admitted to
stroke servie at UPMC Presbyterian, Mercy and Shadyside hospitals.
Lori Shutter, MD, FCCM, FNCS
Study Section --
NIH SBIR Review Panel
Advisory Committee Membership
University of Pittsburgh Medical Center: Hospital
GME Committee
Special Institutional Education Programs Committee (SIEP)
University of Pittsburgh Medical Center: Department
CCM Fellowship Program Directors Committee
CCM Education Committee
Safer Symposium Annual Program Committee
Neurology Executive Committee, UPMC
Neurology Residency Curriculum Committee
Neurology Grand Rounds Planning Committee
UPSOM Non-Tenured Faculty Promotions and Appointments Committee
Stuart Silverman, MS, MD, FAAN
Advisory Committee Membership
Director, MS Service Society Tristate
Member MS Consortium Centers
89
Beth Snitz, PhD
Study Section
Reviewer, Western Psychiatric Institute and Clinic Research Committee
Ad hoc reviewer – Swiss National Science Foundation
NIA-NIH Special Emphasis Panel Reviewer
Pitt ADRC pilot proposal program
Dandan Sun, MD, PhD
Study Sections
NIH ZRG1 CMBG study section, regular member
Advisory Committees
Department of Veterans Affairs DVA Review Committee, Member (Neurobiology C)
AHA Peer Review Committee, Member, Brain 3
American Neurological Surgery Society Resident Research Fellowship Review Committee (Regular Member)
Valerie Suski, DO
Advisory Committees
Neurology Incentive Committee
Neurology Peer Review Committee
Alexandra Urban, MD
Study Sections
AAN Epilepsy Section, awareness of epilepsy and patient education
Practice Management Committee, American Epilepsy Society
Advisory Committees
LKB Neurology Clinic Improvement Committee
Women in Neurology
Clinical Neurophysiology Fellowship Clinical Competency Committee
Clninical Neurophysiology Fellowship Program Evaluation Committee
System Wide Neurodiagnostic Committee
Epilepsy Fellowship Clinical Competency Committee
Epilepsy Fellowship Program Evaluation Committee
Anne Van Cott, MD
Advisory Committees
National
Member of VA/DoD Quality Indicators for Epilepsy Treatment in the VA (QUIET-VA) Expert Panel
Chair, Women Veterans with Epilepsy VA National Epilepsy Centers of Excellence Workshop Group
University and Medical School
Neurology Medical Student Curriculum Committee
Neurology Promotions Committee
VA Professional Committees
VA Epilepsy Consortium VAPHS Medical and Surgical Clinic Expansion Committee
90
VA Research Committee
Member of VA Southeast Epilepsy Center of Excellence Steering
Member of VA Northeast Epilepsy Center of Excellence Advisory Committee
Local
Professional Advisory Board of the Epilepsy Foundation of Western/Central PA, Member
Janet Waters, MD
Advisory Committees
Neurology Resident Selection Committee
Incentive Committee – UPMC Dept of Neurology
Executive Committee – UPMC Dept of Neurology
Lawrence Wechsler, MD
Advisory Committees
National
Chair, Telemedicine Committee, American Stroke Association
Chair, American Society of Neuroimaging Foundation Board
Chair, DSMB Biogen ACTION I and II trials
Member, American Academy of Neurology, Vascular Neurology Task Force
Member, American Academy of Neurology, Representative to Brain Attack Coalition
Member, ATA Telestroke Guideline Committee
Member, Board of Directors, American Society of Neuroimaging
Member, Stroke System Work Group, American Academy of Neurology
Member, Telemedicine Work Group, American Academy of Neurology
Member, McKinney Award Committee, American Society of Neuroimaging
Member, ASN Program Committee
Steering Committee, ACT 1 Trial
University of Pittsburgh
Vice President for Telemedicine, UPMC
Co-director, Neuroscience service line
Member, Department of Neurology Executive Committee
Member, Department of Neurology Promotions Committee
University of Pittsburgh Physicians
Member, UPP Clinical Operations Committee
Kejie Yin, MD, PhD
Advisory Committee
Member, American Heart Association Brain-Stroke Basic Science 2 Peer Review Committee
Naoir Zaher, MD
Advisory Committee
Epilepsy Fellowship PEC (Program Evaluation) Commmittee
Feng Zhang, MD, PhD
Study Section
NSFC, China
91
Advisory Committee
University of Pittsburgh Institutional Animal Care & Use Committee
Michael J. Zigmond, PhD
Advisory Committees
National Advisory Boards:
Chair, Columbia University Udall Center Research Program on Parkinson's disease: Pathogenesis of
Dopamine Neuron Death (Robert Burke, PI)
Scientific Advisory Board, The Michael J. Fox Foundation for Parkinson’s
Scientific Advisory Board, Center for Biomedical Research Excellence, University of Puerto Rico
Chair, Program Advisory Committee, NINDS Specialized Neuroscience Research Program
University Central Del Caribe
Scientific Advisory Committee, Keystone Symposia
American Association for the Advancement of Science
AAAS Committee on Sections member
Neuroscience Section, Secretary
Society for Neuroscientists of Africa – Program Committee
Saša Živković, MD, PhD
Advisory Committees
Member, AAN Subspecialty Qualigy Advisors Group AAN
Member, Quality Improvement Committee, AANEM
Member, Vasculitis Working Group, Brighton Collaboration
Risk Management Review Committee, Department of Neurology, University of Pittsburgh
92
93
Research Grants and Contract Activity
LAST NAME FIRST
NAME AGENCY NAME TITLE OF GRANT
ANNUAL
DC
ANNUAL
IDC TOTAL
Federal Grants: Public Health Service Program Project Grants
K AWARDS
Xia Zongqui NATIONAL INSTITUTES
OF HEALTH
Leveraging genetics and environment to
predict presymptomatic multiple sclerosis $172,076.26 $13,766.08 $185,842.34
$185,842.34
PROGRAM PROJECTS
Clemens Paula Children’s Research
Institute P50 Project 3 $7,116.66 $3,665.09 $10,781.75
Clemens Paula Children’s Research
Institute P50 Admin Core A $1,204.86 $620.50 $1,825.35
Clemens Paula Children’s Research
Institute P50 Project 3 Patient Care Costs $561.49 -$384.59 $176.90
Greenamyre John NATIONAL INSTITUTES
OF HEALTH
Pittsburgh Older Americans Independence
Center $9,198.29 $4,967.03 $14,165.32
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Project 3 $165,693.21 $89,474.32 $255,167.53
Ikonomovic Milos St. Joseph’s Hospital Neurobiology in Mild Cognitive Impairment
in the Elderly $239,013.29 $127,592.39 $366,605.68
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH ADRC – Admin Core A $179,991.48 $96,972.61 $276,964.09
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Alzheimer’s Disease Research Center –
Clinical Core B $415,065.48 $224,135.37 $639,200.85
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH ADRC Core F (Pat Kethchel) $9,323.75 $5,034.83 $14,358.58
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Core A $62,042.94 $33,503.21 $95,546.15
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Project 1 $128,981.04 $37,910.99 $166,892.03
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Project 2 $31,614.20 $16,006.03 $47,620.23
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Project 4 $19,583.04 $10,574.83 $30,157.87
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH ADRC – Admin Project 2 $2,506.13 $1,353.32 $3,859.45
Sanders Laurie NATIONAL INSTITUTES
OF HEALTH ADRC Pilot 2 $8,892.66 $4,802.02 $13,694.68
Snitz Beth NATIONAL INSTITUTES
OF HEALTH ADRC – Core E $76,093.66 $41,090.64 $117,184.30
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Alzheimer’s Disease Research Center –
Project 1 $59,069.30 $19,384.47 $78,453.77
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Imaging Pathophysiology in Aging and
Neurodegeneration Core B $62,051.91 $33,431.09 $95,483.00
Snitz Beth NATIONAL INSTITUTES
OF HEALTH ADRC – Core A $24,812.86 $13,398.97 $38,211.83
$ 2,266,349.37
94
U AWARDS
Bagic Anto Emory University Connections of Brain Aging and Dementia
(CBAD) $3,095.00 $1,671.30 $4,766.30
Bagic Anto Washington University Maternal Outcomes and Neurodevelopment
Effects of Antiepileptic Drugs $16,829.57 $9,088.00 $25,917.57
Berman Sarah NATIONAL INSTITUTES
OF HEALTH DIAN Study $77,443.68 $27,105.35 $104,549.03
Clemens Paula NATIONAL INSTITUTES
OF HEALTH
VBP15, An Innovative Steroid-like
Intervention on DMD: Vision-DMD $38,743.73 $20,921.67 $59,665.40
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Neurodegeneration in Aging in Down
Syndrome (NiAD): A Longitudinal Study of
Cognition and Biomarkers of Alzheimer’s
Disease
$16,852.28 $9,100.22 $25,952.50
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Neurodegeneration in Gaining Down
Syndrome (NiAD) $2,764.33 $1,492.75 $4,257.08
Jadhav Ashutosh Massachusetts General
Hospital NN104/Rhapsody $127,679.37 $58,829.67 $186,509.04
Jankowitz Brian John Hopkins University
Minimally Invasive Surgery =+rt-PA for
Intracerebral hemorrhage evacuation –
MISTIE III
$21,838.87 $5,217.19 $27,056.06
Lopez Oscar HRSA Geriatric Workforce Enhancement Program $17,134.35 $1,370.76 $18,505.21
Lopez Oscar University of Southern
California
A Phase 2a Multi-Center Study of 18F-FDG
PET, safety and tolerability of AZD0530 in
Mild Alzheimer’s Disease
$31,856.30 $4,389.36 $36,245.66
Lopez Oscar University of Southern
California
Alzheimer’s Disease Neuroimaging Imitative
2 (ADNI2) $9,115.32 $318.10 $9,433.42
Lopez Oscar University of Washington NACC Minimum Data Set (MDS) Project $6,741.92 $3,640.60 $10,382.52
Lopez Oscar University of Southern
California
Alzheimer’s Disease Cooperative Study – A4
Study $14,452.85 $4,335.85 $18,788.70
Reddy Vivek NATIONAL INSTITUTES
OF HEALTH Point Project $4,428.67 $2,325.06 $6,753.73
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Connections of Brain Aging and Dementia
(CBAD) $104,394.66 $56,373.15 $160,767.81
Suski Valerie Massachusetts General
Hospital
Phase 3 trial of inosine for Parkinson’s
Disease CCC (SURE PD) $11,851.07 $3,555.33 $15,406.40
Suski Valerie NATIONAL INSTITUTES
OF HEALTH NeuroNEXT Ibudilast Study $6,985.25 $619.53 $7,604.68
Suski Valerie Massachusetts General
Hospital NeuroNEXT NN105 STAIR Study $2,233.48 $637.72 $2,871.20
Urban Alexandria University of Michigan Established Status Epilepticus Treatment
Trial $3,868.76 $2,089.13 $5,957.89
Wechsler Lawrence NATIONAL INSTITUTES
OF HEALTH
Network of Excellence in Neuroscience
Clinical Trials $185,883.23 $95,729.86 $281,613.09
Wechsler Lawrence NATIONAL INSTITUTES
OF HEALTH
Stroke Trials Network – Regional
Coordinating Stroke Center (STN-UP) $200,696.69 $98,214.49 $298,911.18
Wechsler Lawrence NATIONAL INSTITUTES
OF HEALTH
Neurological Emergencies Treatment Trial
(NETT) Network Pittsburgh Clinical Hub $8,431.35 $4,342.13 $12,773.48
Wechsler Lawrence University of Michigan SHINE Project Year 2 $1,169.41 $613.94 $1,783.35
Wechsler Lawrence May Clinic Jacksonville
CREST II Carotid Revascularization and
Medical Management for Asymptomatic
Carotid Stenosis Trial
$28,120.42 $12,165.89 $40,286.31
$ 1,366,757.61
95
R AWARDS
Berman Sarah NATIONAL INSTITUTES
OF HEALTH
Neuronal regulation of mitochondrial
dynamics in models of Parkinson’s Disease $217,339.71 $117,298.14 $334,637.85
Berman Sarah NATIONAL INSTITUTES
OF HEALTH
PINK1 Regulation of Neuronal and
Mitochondrial Homeostasis $10,151.59 $5,481.88 $15,633.47
Burton Edward NATIONAL INSTITUTES
OF HEALTH
Development of zebrafish taupoathy models
for translational research $2,908.26 $1,526.84 $4,435.10
Burton Edward NATIONAL INSTITUTES
OF HEALTH
Pathogenic mechanisms of gene-environment
interactions in Parkinson’s Disease $256,084.39 $138,285.64 $394,370.03
Burton Edward NATIONAL INSTITUTES
OF HEALTH
ROS driven mitochondrial-telomere
dysfunction during environmental stress $9,558.52 $4,918.66 $14,477.18
Cao Guodong NATIONAL INSTITUTES
OF HEALTH White Matter Protection in Cerebral Ischemia $238,323.15 $111,416.60 $349,739.75
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Neuroprotection in Models of Cerebral
Ischemia $81,765.64 $42,109.34 $123,874.98
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Mechanisms of Neurovascular Injury in
Cerebral Ischemia $197,627.14 $97,586.52 $295,213.66
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Na+K+Cl Contransporter in Cerebral
Ischemia $7,923.15 $4,278.51 $12,201.66
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Antidote for inhaled CO poisoning based on
mutationally engineered neuroglobin $7,923.15 $4,278.51 $12,201.66
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Role of CyPgs UCH-L1 in Ischemic Injury
and Recovery $38,031.51 $20,537.07 $58,568.58
Chen Jun NATIONAL INSTITUTES
OF HEALTH
White matter restoration and functional
recovery after experimental stroke $241,311.20 $129,408.12 $370,719.32
Chen Jun NATIONAL INSTITUTES
OF HEALTH
Molecular therapies to promote white matter
restoration after traumatic brain injury $299,270.90 $88,525.98 $387,796.88
Chen Jun NATIONAL INSTITUTES
OF HEALTH MicroRNAs and post-stroke angiogenesis $109,481.39 $47,109.07 $156,590.46
Chen Jun NATIONAL INSTITUTES
OF HEALTH Inducible DNA repair in cerebral ischemia $136,384.46 $67,842.06 $204,226.52
Clemens Paula Children’s Research
Institute
Biomarker Discover and Validation in a
Duchenne Dystrophy Natural History Study:
Agreement 2
$463.91 $243.56 $707.47
Graham Steven NATIONAL INSTITUTES
OF HEALTH
Role of CyPgs UCH-L1 in Ischemic Injury
and Recovery $165,985.07 $89,319.43 $255,304.50
Greenamyre John NATIONAL INSTITUTES
OF HEALTH
MtDNA Damage as a Biomarker for
Environmental Mitochondrial Toxicity $41,068.14 $21,150.09 $62,218.23
Greenamyre John NATIONAL INSTITUTES
OF HEALTH
MtDNA Damage as a Biomarker for
Environmental Mitochondrial Toxicity –
Supplement
$180,212.71 $58,326.62 $238,539.33
Greenamyre John NATIONAL INSTITUTES
OF HEALTH
Alpha-synuclein inhibition of mitochondrial
protein import $309,144.56 $165,836.37 $474,980.93
Greenamyre John NATIONAL INSTITUTES
OF HEALTH
A slowly progressive, endogenous
synucleinopathy model of Parkinson’s disease $19,289.34 $10,176.34 $29,465.68
Greenamyre John University of Texas Health
Science Center
Effects of Insulin-like signaling, aging, and
ubiquinone on C. Elegnas muscle $5,893.04 $3,093.86 $8,986.90
Hu Xiaoming NATIONAL INSTITUTES
OF HEALTH
Immunomodulation of white matter integrity
after stroke $213,182.90 $111,263.93 $324,446.83
Hu Xiaoming NATIONAL INSTITUTES
OF HEALTH
Regulatory T Cell as a restorative therapy for
ischemic stroke $168,147.66 $84,760.73 $252,908.39
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Alpha-synuclein and synaptic vesicle
dysfunction after traumatic brain injury $8,063.98 $4,354.55 $12,418.53
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Development of a PET Tracer Selective for
cerebral amyloid angiopathy $94,504.07 $49,920.38 $144,424.45
Ikonomovic Milos NATIONAL INSTITUTES
OF HEALTH
Natural History of Amyloid Deposition in
Adults with Down Syndrome $9,847.97 $5,317.92 $15,165.89
96
Jovin Tudor Stanford University Imaging of Collaterals in Acute Stroke
(iCAS) $14,231.20 $7,684.85 $21,916.05
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Resilience to Mobility Impairment: Neural
Correlates and Protective Factors $557.37 $287.04 $844.41
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Ultra-high field neuroimaging in elderly after
a two-year exercise intervention $11,016.58 $5,948.97 $16,965.55
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Omega-3, isoflavones & amyloid deposition
in cognitively normal elderly Japanese $4,875.05 $2,632.56 $7,507.61
Lopez Oscar NATIONAL INSTITUTES
OF HEALTH
Role of midlife cardiovascular disease on
Alzheimer’s Pathology and cerebrovascular
reactivity in the young-old
$44,577.32 $24,071.77 $68,649.09
Lopez Oscar University of California San
Diego Characterizing Cognitive Decline in Late Life
Depression – the ADNI-D Project
$14,547.44 $4,364.26 $18,911.70
Lopez Oscar Harvard University Novel lipoprotein particles, brain
abnormalities and risk of dementia and stroke
$13,096.17 $7,071.94 $20,168.11
Lopez Oscar University of Southern
California
Characterizing Cognitive Decline in Late Life
Depression – the ADNI-D Project $6,830.57 $383.28 $7,213.85
Pan Jullie NATIONAL INSTITUTES
OF HEALTH
Multiplexed Multiband MR at 7T: Studies of
Mild Traumatic Brain Injury $2,456.09 $1,289.45 $3,745.54
Pan Jullie NATIONAL INSTITUTES
OF HEALTH
Localization of Surgical Epilepsy: MR
Spectroscopic Imaging $528,613.54 $78,220.18 $606,833.72
Popescu Alexandra NATIONAL INSTITUTES
OF HEALTH
Inside the social perception network:
dynamics, connectivity and stimulation $3,094.95 $1,671.27 $4,766.22
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Amyloid pathology and cognition in normal
elderly $19,210.22 $10,373.54 $29,583.76
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Mild cognitive impairment: A prospective
community study $14,189.20 $7,662.13 $21,851.33
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Role of midlife cardiovascular disease on
Alzheimer’s Pathology and cerebrovascular
reactivity in the young-old
$3,431.54 $1,853.07 $5,284.61
Snitz Beth NATIONAL INSTITUTES
OF HEALTH
Alzheimer neuroimaging-biomarkers in pre-
clinical cognitive decline from a population-
based study
$108,752.13 $43,912.40 $152,664.53
Stetler Ruth NATIONAL INSTITUTES
OF HEALTH DNA repair promotes stroke recovery $11,516.27 $5,249.49 $16,765.76
Sun Dandan NATIONAL INSTITUTES
OF HEALTH
Na-K-CL contransporter (NKCC1) in
Gilioblastoma Multiforme $161,502.65 $54,961.03 $216,463.68
Sun Dandan NATIONAL INSTITUTES
OF HEALTH
Na-K-CL contransporter (NKCC1) in
Gilioblastoma Multiforme – Supplement $8,659.03 $0.00 $8,659.03
Sun Dandan NATIONAL INSTITUTES
OF HEALTH
Liberation of Intracellular zinc and neuronal
cell death $10,388.49 $5,609.81 $15,998.30
Sun Dandan NATIONAL INSTITUTES
OF HEALTH Na-K-Cl cotransporter in cerebral ischemia $268,976.65 $131,835.38 $400,812.03
Sun Dandan NATIONAL INSTITUTES
OF HEALTH Targeting ER stress in TBI $146,807.40 $75,877.18 $222,684.58
Sun Dandan NATIONAL INSTITUTES
OF HEALTH
Novel long non-coding RNAs in neuronal
survival in focal cerebral ischemia $8,570.50 $4,628.08 $13,198.58
Sun Dandan NATIONAL INSTITUTES
OF HEALTH
The role on Na/H exchanger in cerebral
ischemia $124,107.27 $66,897.20 $191,004.47
Sun Dandan NATIONAL INSTITUTES
OF HEALTH White matter protection in cerebral ischemia $8,310.77 $4,487.83 $12,798.60
Suski Valerie NATIONAL INSTITUTES
OF HEALTH
Neural substrates of deterministic decision
making $645.31 $348.47 $993.78
Wechsler Lawrence Rutgers University CREST $6,317.71 $1,516.22 $7,833.93
Xia Zongqi NATIONAL INSTITUTES
OF HEALTH
Integrating electronic health records and
genomics to predict Multiple Sclerosis drug
response
$73,139.88 $39,028.05 $112,167.93
97
Yin Kejie NATIONAL INSTITUTES
OF HEALTH
Long non-coding RNAs and cerebrovascular
endothelial cell pathology in ischemic stroke $90,833.26 $49,050.01 $139,883.27
Yin Kejie NATIONAL INSTITUTES
OF HEALTH MicroRNAs and post-stroke angiogenesis $168,333.85 $81,596.65 $249,930.50
Yin Kejie NATIONAL INSTITUTES
OF HEALTH Kruppel-like factor 11 and ischemic stroke $201,847.36 $108,969.15 $310,816.51
Zhang Feng NATIONAL INSTITUTES
OF HEALTH
A novel mechanism of neurovascular
protection in ischemic tolerance $252,269.16 $136,225.38 $388,494.54
Zigmond Michael NATIONAL INSTITUTES
OF HEALTH
Mechanisms of exercise-induced protection
and rescue in models of dopamine loss $5,974.62 $3,076.94 $9,051.56
Zigmond Michael NATIONAL INSTITUTES
OF HEALTH
Building international research ethics capacity
in China $257,042.16 $20,563.44 $277,605.60
Zigmond Michael NATIONAL INSTITUTES
OF HEALTH
Selective Glucocorticoid action in the
developing brain $13,889.93 $7,500.56 $21,390.49
Zigmond Michael Case Western Reserve
University
Role of GDNF and ER stress in effects of
acupuncture in models of Parkinsonism $89,709.45 $48,336.42 $138,045.87
Zigmond Michael Case Western Reserve
University
Reposition Gilptins for Parkinson’s disease
treatment $14,482.66 $0.00 $14,482.66
$ 8,310,241.98
Commonwealth Grants
Greenamyre John
Commonwealth of
Pennsylvania Department of
Education
Pittsburgh Institute for Neurodegenerative
Diseases $637.89 0 $637.89
$ 637.89
Other Federal Grants
Burton Edward National Science
Foundation
Towards Assessing and Mitigating the
Toxicity of Metal Nanoparticles $1,501.19 $792.86 $2,303.05
Clemens Paula Children’s Hospital of
Pittsburgh
Clinical trial of Coenzyme Q10 and
Prednisone in Duchenne M.D. $82,851.57 $20,712.95 $103,564.52
Clemens Paula Children’s Research
Institute
Establishing Minimal Clinically Important
Differences for Current Clinical Trial
Endpoints and Composite Outcome Measure
in Duchenne Muscular Dystrophy Agreement
7
$2,856.53 $1,499.69 $4,356.22
Clemens Paula ReveraGen BioPharma, Inc. Phase IIa Study of VBP15 for the Treatment
of Duchenne Muscular Dystrophy $42,578.82 $22,992.58 $65,571.40
Ikonomovic Milos U.S. Army In Vivo Neuroimaging Biomarker Panel for
Chronic Traumatic Encephalopathy $786.81 $424.86 $1,211.67
Lopez Oscar Department of Defense Chemogenics Systems Pharmacology
approach for TBI and AD Research $14,544.11 $7,853.80 $22,397.91
Lopez Oscar Ohio State University Women Health Initiative – Regional Center $2,013.11 $1,087.09 $3,100.20
Sun Dandan U.S. Army Chemogenics Systems Pharmacology
approach for TBI and AD Research $9,349.70 $5,048.87 $14,398.57
$216,903.54
98
Society and Foundation Funding
Andolina Laurie Bumpus Foundation
Mitochondrial DNA damage: screening tool
and novel therapeutic target for Parkinson’s
Disease
$13,776.60 $0.00 $13,776.60
Andolina Laurie Michael J. Fox Foundation Lrrk2 kinase activity and mitochondrial DNA
dame in Parkinson’s Disease $16,995.71 $1,699.57 $18,695.28
Burton Edward UPMC
Neuronal mitochondrial quality control in
vivo: live imaging of mitophagy in dopamine
neurons during aging and age
$19,117.48 $0.00 $19,117.48
Clemens Paula Muscular Dystrophy
Association
CINRG Becker Natural History Study –
Travel Funding $1,145.30 $114.54 $1,259.84
Clemens Paula Foundation to Eradicate
Duchenne, Inc.
Use of Microsoft Bands as an outcome
measure in boys with DMD – Parallel study
to Clinical Study Protocol VBP15
$10,661.17 $2,665.39 $13,326.56
DiMaio Roberto RiMED Foundation Cannabinoids therapeutic potential in the
prevention of chronic epilepsy $121,314.91 $36,248.83 $157,563.74
Greenamyre John American Parkinson’s
Disease Association
PET, Posturographic and Clinical Marker of
Early PD $39,810.20 $0.00 $39,810.20
Greenamyre John DSF Charitable Foundation Research on Mitochondria in
Neurodegenerative Disease $63,694.84 $0.00 $63,694.84
Hu Xiaoming AHA DHA post-treatment alleviates white matter
injury after cerebral ischemia $48,777.08 $4,877.74 $53,654.82
Lacomis David Massachusetts General
Hospital
A Multicenter Study for the Discovery and
Validation of Serial ALS Biomarkers $30,509.54 $4,576.43 $35,085.97
Lopez Oscar University of Southern
California
Alzheimer’s Disease Neuroimaging Initiative
3 (ADNI 3) $9,730.46 $2,919.14 $12,649.60
Lopez Oscar University of Southern
California
Longitudinal Evaluation of Amyloid Risk and
Neurodegeneration – the LEARN Study $22,773.53 $2,277.37 $25,050.90
Rocha Emily American Parkinson’s
Disease Association
Defining the role of glucocerebrosidase and
TFEB in Parkinson’s Disease $21,168.50 $0.00 $21,168.50
Rocha Emily PDF
Loss of glucocerebrodidase increase
dopaminergic neuronal vulnerability by
impairing autophagy flux
$54,962.44 $0.00 $54,962.44
Shi Yejie AHA Heat Shock Proteins and Neurovascular
Protection in Cerebral Ischemia $25,258.09 $0.00 $25,258.09
Song Shanshan AHA
Targeted knockout of microglial Na+/H+
exchanger-1 in mice improves neurological
function recovery after stroke
$22,777.82 $0.00 $22,777.82
Starr Matthew Duke University
Patient-Centered Research into Outcomes
Stroke Patients Prefer and Effectiveness
Research
$1,250.00 $500.00 $1,750.00
Suski Valerie CHDI Foundation, Inc
Enroll-HD: A Prospective Registry Study in
Global Huntington’s Disease Cohort A CHDI
Foundation Project
$61,641.89 $9,246.26 $70,888.15
Van Laar Amber American Brain Foundation
Parkin overexpression and the role of
neuroprotection clinician-scientist
development award
$77,140.98 $0.00 $77,140.98
Zivkovic Sasa GBS/CIDP Foundation
International
International Guillain-Barre Syndrome
Outcome Study (IGOS) $379.50 $199.26 $578.76
$ 728,210.57
Veterans Administration Medical Center Grants
Burton Edward US Department of Veterans
Affairs IPA Jianming Chen $34,810.52 $0.00 $34,810.52
Cao Guodong US Department of Veterans
Affairs IPA F. Chen $21,076.97 $0.00 $21,076.97
99
Chen Jun US Department of Veterans
Affairs IPA Zhongfang Weng $18,830.97 $0.00 $18,830.97
Chen Jun US Department of Veterans
Affairs IPA Sulaiman Hassan $43,804.22 $0.00 $43,804.22
Chen Jun US Department of Veterans
Affairs IPA Feng Zhang $27,235.95 $0.00 $27,235.95
Chen Jun US Department of Veterans
Affairs IPA Qing Ye $35,592.45 $0.00 $35,592.45
Chen Jun US Department of Veterans
Affairs IPA Yejie Shi $13,431.64 $0.00 $13,431.64
Clemens Paula US Department of Veterans
Affairs IPA Daniel Reay (CPPF) $23,206.26 $0.00 $23,206.26
Clemens Paula US Department of Veterans
Affairs IPA Daniel Ready (GREC) $15,565.19 $0.00 $15,565.19
Graham Steven US Department of Veterans
Affairs VA Contract Marie Rose $10,494.80 $0.00 $10,494.80
Graham Steven US Department of Veterans
Affairs IPA Marie Rose $31,484.44 $0.00 $31,484.44
Ikonomovic Milos US Department of Veterans
Affairs IPA Zhiping Mi $63,922.73 $0.00 $63,922.73
Ikonomovic Milos US Department of Veterans
Affairs IPA William Paljug $35,645.11 $0.00 $35,645.11
Sun Dandan US Department of Veterans
Affairs IPA Victoria Pigott $35,812.04 $0.00 $35,812.04
Sun Dandan US Department of Veterans
Affairs IPA Karen Carney $26,726.84 $0.00 $26,726.84
Sun Dandan US Department of Veterans
Affairs IPA Shanshan Song $5,029.58 $0.00 $5,029.58
$ 442,669.71
Industry Research Funding
Bagic Anto Persyst Development Corp
Multi-reader marked adult seizure EEG
dataset: comparison of human expert
assessments to Persyst automated seizure and
spike detection results
$18,975.00 $11,195.25 $30,170.25
Berman Sarah Quintiles
A Phase II/III randomized, double-blind,
placebo-controlled, multicenter study of 3
potential disease modify (DIAN-TU)
$173,293.88 $43,323.64 $216,617.52
Clemens Paula Genzyme Global Acid-Alfa-Glucosidase Treatment
Sustainability Program (GATS) $53.25 $0.00 $53.25
Clemens Paula Genzyme
A Prospective Safety Sub-Registry to Assess
Anaphylaxis and Severe Allergic Reactions
and Severe Cutaneous and Systemic
Immune-Mediated Reactions with
Alglucosidase Alfa Treatment
$1,480.89 $370.24 $1,851.13
Clemens Paula Children’s Research
Institute NS Pharma Phase 2 Project set-up $7,899.33 $4,858.10 $12,757.43
100
Clemens Paula ReveraGen BioPharma Phase IIa Study of VBP15 for the Treatment
of Duchenne Muscular Dystrophy $3,712.00 $2,004.50 $5,716.50
Clemens Paula Children’s Research
Institute
A multi-center collaborative study on the
clinical features, expression profiling, and
quality of life of infantile onset
facioscapulohumeral muscular dystrophy
$647.61 $194.29 $841.90
Clemens Paula TRiNDS
A Phase II, Dose Finding Study to Assess the
Safety, Tolerability, Pharmacokinetics, and
Pharmacodynamics of NS-065/NCNP-01 in
Boys with Duchenne Muscular Dystrophy
$533.72 $328.23 $861.95
Clemens Paula Genzyme Lysosomal Disorders Registry $7,604.26 $1,901.08 $9,505.34
Greenamyre John Merck
Development of a rodent model of GBA1
mutant carriers in sporadic Parkinson’s
Disease
$34,188.55 $19,939.64 $54,128.19
Greenamyre John Sanofi-Aventis
Screening of LRRK2 therapeutics for
Parkinson's disease based on a mitochondrial
phenotype (LRRK2 screening)
$4,297.30 $2,642.84 $6,940.14
Greenamyre John Sanofi-Aventis
Screening of LRRK2 therapeutics for
Parkinson's disease based on a mitochondrial
phenotype (Assay validation)
$15,599.03 $9,593.12 $25,192.15
Greenamyre John Biogen Testing Parkinson's therapeutics in an novel
animal model $57,149.86 $35,147.17 $92,297.03
Ikonomovic Milos General Electric
Assessing the influence of cored and diffuse
Ab plaquest on CN-Flutemetamol
fluorescence signal in histological sections
from Alzheimer’s disease brains
$6,779.32 $3,999.82 $10,779.14
Jain Samay Voyager Therapeutics
An Open-label Safety and Efficacy Study of
Escalating Doses of AAV2-hAADC
Administered by MRI-Guided Convective
Infusion into the Putamen of Participants with
Parkinson’s Disease with Fluctuating
Responses to Levodopa
$42,160.06 $14,756.04 $56,916.10
Lopez Oscar University of California Anti-Amyloid Treatment in Asymptomatic
Alzheimer’s Disease (Study A4) $2,323.99 $581.00 $2,904.99
Lopez Oscar University of California
A Phase 2 multi-center, randomized, double
blind, placebo controlled, parallel group study
to evaluate the efficacy and safety of T-
817MA in patients with mild to moderate
Alzheimer's Disease (US202)
$69,056.14 $17,264.12 $86,320.26
Lopez Oscar University of Southern
California
Anti-Amyloid Treatment in Asymptomatic
Alzheimer's Disease $131,404.85 $61,650.67 $193,055.52
Wechsler Lawrence Sunovion Pharmaceuticals
A double-blind controlled Phase 2B Study of
the Safety and Efficacy of Modified Stem
Cells (SB623) in patients with Chronic Motor
Deficit from Ischemic Stroke (Sanbio 2 Un-
blinded)
$2,956.56 $886.97 $3,843.53
Wechsler Lawrence Sunovion Pharmaceuticals
A double-blind controlled Phase 2B Study of
the Safety and Efficacy of Modified Stem
Cells (SB623) in patients with Chronic Motor
Deficit from Ischemic Stroke (Sanbio 2 Un-
blinded)
$15,928.40 $4,778.54 $20,706.94
Wechsler Lawrence SanBio
A Phase 1/2A Study of the safety and efficacy
of modified stromal cells in patients with
stable ischemic stroke
$137,473.43 $48,115.68 $185,589.11
$ 1,017,048.37
$ 14,534,661.38
101
Faculty Research Collaborations
Arun Antony, MD
Murat Akcakaya, PhD University of Pittsburgh Department of Engineering
Brian Hanrahan, MD Chippenham Hospital, Richmond, VA, Department of Internal Medicine
Pulkit Grover, PhD Carnegie Mellon, Department of Engineering
Burak Erem, PhD Northwestern University, Boston, MA, Department of Electrical
Engineering
Rebecca Mackenzie, PhD University of Minnesota, Department of Chemistry
Anto Bagic, MD, PhD
James Becker, PhD University of Pittsburgh Department of
R. Mark Richardson, MD, PhD University of Pittsburgh Department of Neurosurgery
Jullie Pan, MD, PhD University of Pittsburgh Department of Neurology
Fernando Maestu, PhD Aalto University, Helsinki, Finland
Wei Wang, MD, PhD University of Pittsburgh Department of Bioengineering, Physical
Medicine and Rehabilitation
Gustavo Sudre, PhD NIMH, NIH, Bethesda, MD
Douglas Weber, PhD University of Pittsburgh Department of Bioengineering
Mark Scheuer, MD Persyst Development Corporation, Prescott, AZ
Xin Li, PhD Carnegie Mellon University Department of Electrical and Computer
Engineering
Michael Cole, PhD Rutgers University Center for Molecular & Behavioral Neuroscience
Richard Randall, PhD Carnegie Mellon University School of Music
Julie Fiez, PhD University of Pittsburgh Department of Neuroscience
Rita Hari, MD, PhD, Aalto University, Helsinki, Finland
Sarah Berman, MD, PhD
Edward Burton, MD, Phil University of Pittsburgh Department of Neurology
J. Timothy Greenamyre, MD, PhD University of Pittsburgh Department of Neurology
Valerie Suski, DO University of Pittsburgh Department of Neurology
Laurie Sanders, PhD University of Pittsburgh Department of Neurology
Kenneth Hallows, MD, PhD University of Pittsburgh Medicine and Cell Biology & Physiology
Alexander Sorkin, PhD University of Pittsburgh Department of Cell Biology
Julia Kofler, PhD University of Pittsburgh Department of Neuropathology
Claudette St. Croix, PhD University of Pittsburgh Department of Environmental and Occupational
Health
Simon Watkins, PhD University of Pittsburgh Center for Biologic Imaging
Charleen Chu, MD, PhD University of Pittsburgh Department of Neuropathology
R. Mark Richardson, MD University of Pittsburgh Department of Neurosurgery
Michael Palladino, PhD Univeristy of Pittsburgh Department of Pharmacology
Yvette Conley, PhD University of Pittsburgh School of Nursing
Douglas Kondziolka, MD University of Pittsburgh Department of Neurosurgery
Kari Fladmark, PhD University of Bergen, Norway
Ole Isacson, PhD Harvard Medical School
J. Marie Hardwick, PhD Johns Hopkins University
Fernando Pineda, PhD Johns Hopkins University
102
Edward Burton, MD, DPhil, FRCP
J. T. Greenamyre, MD, PhD University of Pittsburgh Department of Neurology and PIND
Sarah Berman, MD, PhD University of Pittsburgh Department of Neurology and PIND
Simon Watkins, PhD University of Pittsburgh Center for Biologic Imaging
Goetz Veser, PhD University of Pittsburgh Department of Chemical Engineering
Claudette St. Croix, PhD University of Pittsburgh Center for Biologic Imaging
Oliver Bandmann, MD, PhD University of Sheffield, UK
Bennet Van Houten, PhD University of Pittsburgh Department of Phamacolog and Chemical
Biology and UPCI
Patricia Opresko, PhD University of Pittsburgh, Department of Environmental and Occupational
Health and UPCI
Marcel Bruchez, PhD Carnegie Mellon University
Franca Cambi, MD, PhD
Haining Zhu, PhD
University of Kentucky, Department of Biochemistry
Quasar Padiath, PhD University of Pittsburgh, Department of Human Genetics
Mandy McGeachy, PhD University of Pittsburgh, Department of Medicine
Guodong Cao, PhD
Xiaoming Hu, MD University of Pittsburgh Department of Neurology
Rehana Leek Duquesne University
Feng Zhang University of Pittsburgh Department of Neurology
Yanqin Gao University of Pittsburgh Department of Neurology
Jun Chen, MD University of Pittsburgh Department of Neurology
Dandan Sun University of Pittsburgh Department of Neurology
Yumin Luo Capital Medical Univeristy, China
Edward Dixon Univeristy of Pittsburgh
Jian Xiao Wenzhou Medical University, China
Xunming Ji Capital Medical University, China
Jun Chen, MD
Steven Graham, MD, PhD University of Pittsburgh Department of Neurology
Tim Greenamyre, MD, PhD University of Pittsburgh Department of Neurology
Dandan Sun, MD, PhD University of Pittsburgh Department of Neurology
Yanqin Gao, MD Fudan University, State Key Laboratory of Medical Neurobiology
Xunming Ji, MD, PhD Beijing Capital Medical University, Xunwu Hospital
Yun Xu, MD, PhD Nanjing University, Department of Neurology
Guodong Cao, PhD University of Pittsburgh Department of Neurology
C. Edward Dixon, PhD University of Pittsburgh Department of Neurosurgery
Robert M. Friedlander, MD University of Pittsburgh Department of Neurosurgery
Stephen F. Badylak, DVM, PhD, MD University of Pittsburgh Department of Pathology
Jailing Liu, PhD University of California at SF
Rehana Leak, PhD Duquesne University
Baoliang Sun, MD Shangdong University
Michael Bennett, D.Phil Albert Einstein College of Medicine
103
Paula Clemens, MD
Paul Robbins, PhD The Scripps Research Institute, Jupiter, Florida
Hoda Abdel-Hamid, MD University of Pittsburgh Department of Pediatric Neurology
Sasa Zivkovic, MD University of Pittsburgh Department of Neurology
Denis Guttridge, PhD Ohio State University Department of Molecular Virology, Immunology &
Medical Genetics
CINRG investigators Children’s National Medical Center and other institutions
Dana Ascherman, MD, PhD University of Florida, Miami, Florida
Eric Hoffman, PhD Children’s National Medical Center, Washington, DC
Kanneboyina Nagaraju, PhD Children’s National Medical Center, Washington, DC
Yetrib Hathout, PhD Binghamton Univrsity, Minghamton, NY
Araya Puwanant, MD University of Pittsburgh, Department of Neurology
Roxanna Bendixen, PhD University of Pittsburgh, Department of Occupational Therapy
Jan Drappatz, MD
Nduka Amankulor, MD University of Pittsburgh Department of Neurosurgery
Johnathan Engh, MD University of Pittsburgh Department of Neurosurgery
Paula Sherwood University of Pittsburgh School of Nursing
Brian Alexander, MD, MPH Dana-Farber Cancer Institute, Harvard University
Kathy Gardner, MD
Catalina Cleves, MD Children’s Hospital of Pittsburgh
Inna Vaisleib, MD Children’s Hospital of Pittsburgh
Amy Goldstein, MD Children’s Hospital of Pittsburgh
Monica Naik, MD Children’s Hospital of Pittsburgh
Robert Kaniecki, MD University of Pittsburgh Department of Neurology Headache Center
Barbara Vogler, MD University of Pittsburgh Department of Neurology Headache Center
Claire Yanta, MD University of Pittsburgh Department of Neurology Headache Center
Michael Barmada, PhD University of Pittsburgh Department of Human Genetics
Steven H. Graham, MD, PhD
Jun Chen, MD University of Pittsburgh Department of Neurology
Patrick Kohanek, MD University of Pittsburgh Department of Critical Care Medicine
C. Edward Dixon PhD University of Pittsburgh Department of Neurology
Sam Poloyak, PhD University of Pittsburgh School of Pharmacy
Valerian Kagan, PhD
University of Pittsburgh Department of Occupational and Environmental
Health
Robert Clark, MD University of Pittsburgh Department of Critical Care Medicine
Robert Hickey MD University of Pittsburgh Department of Pediatrics
German Barrioneuva University of Pittsburgh Department of Neuroscience
J. Timothy Greenamyre, MD PhD
Sarah Berman University of Pittsburgh Department of Neurology
Teresa Hastings University of Pittsburgh Department of Neurology
104
Teresa Hastings, PhD
Jun Chen, MD University of Pittsburgh Department of Neurology
Sarah Berman, MD, PhD University of Pittsburgh Department of Neurology
Edward Burton, MD, DPhil, FRC University of Pittsburgh Department of Neurology
J. T. Greenamyre, MD, PhD University of Pittsburgh Department of Neurology
Guodong Cao, PhD University of Pittsburgh Department of Neurology
Valerian Kagan, PhD University of Pittsburgh Department of Environmental and
Occupational Health
Charleen Chu, MD, PhD University of Pittsburgh Department of Pathology
Rock Heyman, MD
Christopher Chermansky University of Pittsburgh Department of Urology
Quasar S. Padiath University of Pittsburgh Department of Human Genetics
Gulay Alper University of Pittsburgh Department of Pediatrics
David Levinthal University of Pittsburgh Department of Medicine (Gastroenterology)
Eric Hoffman, PhD
Emily Rocha, PhD University of Pittsburgh Department of Neurology
Roberto DiMaio, PhD University of Pittsburgh Department of Neurology
Chris Bodle, PhD University of Pittsburgh Department of Neurology
Xiaoming Hu, MD
Yanqin Gao Fudan University, State Key Laboratory of Medical Neurobiology and
Institute of Brain Sciences
Rehana Leak, PhD Duquesne University, Myland School of Pharmacy
Binfeng Lu, PhD University of Pittsburgh, Department of Immunology
Angus W. Thomson, PhD University of Pittsburgh, Starzl Transplantation Institute, Department
of Surgery
Jun Chen, MD University of Pittsburgh, Department of Neurology
Michael VL. Bennett, D.Phil Albert Einstein College of Medicine, Department of Neuroscience
Frank Faraci, PhD University of Iowa Carver College of Medicine, Department of Internal
Medicine and Pharmacology
105
Ed Burton University of Pittsburgh Department of Neurology
Robert Friedlander University of Pittsburgh Department of Neurosurgery
Don DeFranco University of Pittsburgh Department of Pharmacology
Charleen Chu University of Pittsburgh Department of Neuropathology
Max Hammer, MD
Tudor Jovin, MD University of Pittsburgh, Department of Neurology
Marlene Behrman, MD Carnegie Mellon, Neuropsychology
Kees Polderman, MD University of Pittsburgh, Department of Critical Care
Milos Ikonomovic, MD
Robert Sweet, MD, PhD
University of Pittsburgh Department of Psychiatry
William Klunk, MD, PhD University of Pittsburgh Department of Psychiatry
Chester Mathis, PhD University of Pittsburgh Department of Radiology
Patrick Kochanek, MD, PhD
University of Pittsburgh Department of Anesthesiology
Edward Dixon, PhD University of Pittsburgh Department of Neurosurgery
Katsuyoshi Mizukami, MD University of Tsukuba Department of Psychiatry, Japan
Elliott Mufson, PhD Rush University Medical Center Department of Neurological Sciences
Stephen Scheff, PhD University of Kentucky
Teresa Gomez-Isla, MD Massachusetts General Hospital, Department of Neurology
Bernardino Ghetti, MD Indiana University School of Medicine, Department of Pathology
Anthony Kline, PhD University of Pittsburgh Department of PhysMed and Rehabilitation
Ben Handen, PhD University of Pittsburgh Department of Psychiatry
Matthew Harper, PhD Iowa City VA Medical Center, Neurobiology
Alberto Valzquez, PhD Univeristy of Pittsburgh Department of Radiology
Ashutosh Jadhav, MD, PhD
Tudor Jovin, MD University of Pittsburgh Department of Neurology
Maxim Hammer, MD University of Pittsburgh Department of Neurology
Lawrence Wechsler, MD University of Pittsburgh Department of Neurology
Matthew Starr, MD University of Pittsburgh Department of Neurology
Bradley Molyneaux, MD, PhD University of Pittsburgh Department of Neurology
Brian Jankowitz, MD University of Pittsburgh Department of Neurosurgery
Brad Gross, MD University of Pittsburgh Department of Neurosurgery
Chris Martin-Gill, MD University of Pittsburgh Department of Emergency Medicine
Frank Guyette, MD University of Pittsburgh Department of Emergency Medicine
Samay Jain, MD
Tim Greenamyre, MD, PhD University of Pittsburgh Department of Neurology
Stuart Steinhauer University of Pittsburgh Department of Psychiatry
S. Studenski University of Pittsburgh Department of Medicine
David Lacomis, MD University of Pittsburgh Department of Neurology
Elsa Strotmeyer University of Pittsburgh Department of Epidemiology
Anne Newman University of Pittsburgh Department of Epidemiology
Hazem Samy University of Pittsburgh Department of Ophthalmology
Peter Gianaros University of Pittsburgh Department of Psychiatry
Max Levine Siena College Department of Psychology
Thanh Ton University of Washington Department of Epidemiology
Will Longstreth University of Washington Department of Neurology
Elan D. Louis Neurological Institute, Columbia University Medical Center
Evan Thacker University of Washington Department of Epidemiology
106
Sirwan Darweesh University Medical Center Rotterdam
Seo Young Park University of Pittsburgh Department of Medicine
Dorothy K. Sit University of Pittsburgh Western Psychiatric Institute
Danielle Normolle University of Pittsburgh
David Goldstein National Institutes of Health
Peter LeWitt Henry Ford Hospital
Margaret Schenkman University of Colorado Denver Department of Physical Medicine and
Rehab
Douglas Landsittel University of Pittsburgh Center for Research on Health Care Data
Thomas H. Mosley, Jr. University of Mississippi Medical Center
Sudha Seshadri Boston University
Alvaro Alonso University of Minnesota
Mary Lou Biggs University of Washington
Honglei Chen National Institutes of Health
Joseph C. Delaney University of Washington
Sam Frank Boston University
Daniel Corcos University of Illinois at Chicago
Robert Hauser University of South Florida
Alexa Beiser Boston University
Tudor Jovin, MD
Lawrence Wechsler, MD University of Pittsburgh Department of Neurology
David Lacomis, MD
Christopher Donnelly University of Pittsburgh Brain Institute
Andrew Schwartz University of Pittsburgh Brain Institute
Peter Strick University of Pittsburgh Brain Institute
Chester Oddis University of Pittsburgh Department of Rheumatology
Robert Friedlander University of Pittsburgh Department of Neurosurgery
Diane Carlisle University of Pittsburgh Department of Neurosurgery
Rohit Aggarwal University of Pittsburgh Division of Rheumatology
Steve Meriney University of Pittsburgh Department of Neuroscience
Frank Lieberman, MD
Paula Sherwood University of Pittsburgh Department of Acute Tertiary Nursing
James Mountz University of Pittsburgh Department of Radiology
Hideho Okada University of Pittsburgh Department of Neurological Surgery
Ian Pollack University of Pittsburgh Department of Neurological Surgery
Hao Liu, MD, PhD
Steven H. Graham, MD, PhD University of Pittsburgh Department of Neurology
Robert W. Hickey, MD University of Pittsburgh, Department of Pediatrics
107
Oscar Lopez, MD
Cyrus Raji University of California-Los Angeles, Department of Radiology
Paul Thompson University of California-LA Departments of Radiology and Neurology
Debby Tsuang University of Washington, Seattle
Merce Boada i Rovira Fundació ACE, Barcelona, Spain
Annette Fitzpatrick University of Washington, Seattle
James Leverenz Cleveland Clinic
Sudha Seshardi Boston University
Lenore Launer National Institute on Aging
Maike Janssen Harvard University
Lazarus Mayoglou, DO
Sasha Dionisio, md Mater Center for Neurosciences, S Brisbane, QLD
Sung-Min Cho, MD
Bradley Lega, MD, PhD UT Southwestern Medical Center
David Prime, BEng
Patrick Flanigan, MD Neurological Surgery, Greensburg, PA
Richard Leahy, MD, PhD Univeristy of Souther California, Los Angeles
Jorge Gonzalez-Martinez, MD, PhD Cleveland Clinic
Dileep Nair, MD Cleveland Clinic
John Mosher, PhD Cleveland Clinic
Bradley Molyneaux, MD, PhD
Jon Rittenberger, MD
University of Pittsburgh Emergency Medicine
Taylor Kimberly, MD, PhD Massachusetts General Hospital
Clifton Callaway, MD, PhD University of Pittsburgh Emergency Medicine
Dimitrios Nacopoulos, MD
ZA Ahmed
S. John
N. Papesh
D. Levine
C. Bamford
Jullie Pan, PhD
Ruben Kuzniecky, MD New York University School of Medicine
Oded Gonen, PhD New York University School of Medicine
T. Kevin Hitchens, PhD Carnegie Mellon University
Araya Puwanant, MD
Paula Clemens, MD University of Pittsburgh Department of Neurology
Robert Griggs, MD University of Rochester Department of Neurology
Charles Thornton, MD University of Rochester Department of Neurology
Susan Greenspan, MD University of Pittsburgh Department of Medicine
Cynthia Britton, MD University of Pittsburgh Department of Radiology
108
Gwendolyn Sowa, MD, PhD University of Pittsburgh Department of Physical Medicine and
Rehabilitation
Sara Piva, PhD Univeristy of Pittsburgh, School of Health and Rehabilitation Sciences
Peggy Nopoulos, MD University of Iowa, Department of Psychiatry
Ami Mankodi, MD NIH/Neurogenetics Branch
Vivek Reddy, MD
Maxim Hammer, MD University of Pittsburgh Department of Neurology
Tudor Jovin, MD University of Pittsburgh Department of Neurology
Marcelo Rocha, MD, PhD
Jun Chen, MD University of Pittsburgh Department of Neurology
Tudor Jovin, MD University of Pittsburgh Department of Neurology
Kejie Yin, MD, PhD Univeristy of Pittsburgh Department of Neurology
Sherry Chou, MD University of Pittsburgh Department of Neurology
Bradley Molyneaux, MD, PhD University of Pittsburgh Department of Neurology
Sruti Shiva, PhD University of Pittsburgh Department of Pharmacology
Clifton Callaway, Md, PhD University of Pittsburgh Department of Emergency Medicine
Timothy Greenamyre, MD, PhD University of Pittsburgh Department of Neurology
Lori Shutter, MD, FCCM, FNCS
David Okonkwo, MD, PhD
University of Pittsburgh Department of Neurology
Cliff Callaway, MD University of Pittsburgh Department of Emergency Medicine
Jon Rittenberger, MD University of Pittsburgh Department of Emergency Medicine
Marilyn Hravnak, PhD, RN University of Pittsburgh, School of Nursing
Beth Snitz, PhD
Oscar Lopez, MD University of Pittsburgh Department of Neurology
William Klunk, PhD, MD University of Pittsburgh Department of Psychiatry
Mary Ganguli, MD University of Pittsburgh Department of Psychiatry
James Becker, PhD University of Pittsburgh Department of Psychiatry
Chester Mathis, PhD University of Pittsburgh Department of Radiology
Howard Aizenstein, MD, PhD University of Pittsburgh Department of Psychiatry
Neelesh Nadkarni, MD University of Pittsburgh Department o fMedicine,Geriatric Medicine
Division
Joyce Chang, PhD University of Pittsburgh Department of Medicine
Josif Stakic, MD
Ajitesh Ojha, MD University of Pittsburgh Department of Neurology
Robert Kaniecki, MD University of Pittsburgh Department of Neurology
Matthew Starr, MD
Ashu Jadhav, MD University of Pittsburgh Department of Neurology
Tudor Jovin, MD University of Pittsburgh Department of Neurology
Samir Saba, MD University of Pittsburgh Department of Cardiology
Robert Kormos, MD University of Pittsburgh Department of Cardiology
109
Ruth Anne Stetler, PhD
Rehana K. Leak, PhD Duquesne University
Yanqin Gao, MD Fudan University
Michael Bennett, PhD Albert Einstein
Jana Kainerstorfer, PhD Carnegie Mellon Univeristy
Michelle Stevens, DO
Erica Grazioli, DO University of Pittsburgh Medical Center - Hamot
Dandan Sun, MD, PhD
Ed Dixon, PhD University of Pittsburgh
Elias Aizenman, PhD University of Pittsburgh
Jun Chen, MD, PhD University of Pittsburgh
Seth Alper, MD, PhD Harvard Medical School
Kevin Hutchins, PhD Carnegie Mellon University
Vitorrio Gallo, PhD National Children’s Hospital
Guodong Cao, PhD University of Pittsburgh Department of Neurology
John Kuo, MD, PhD University of Wisconsin-Madison
Kris Kahle, MD, PhD Harvard Medical School
Jane Wang, PhD University of Pittsburgh
Xiangqun Xie, PhD University of Pittsburgh
Tija Jacob, PhD University of Pittsburgh
Anders Persson, PhD University of California – San Fransisco
Gary Kohanbash University of Pittsburgh
Maria Castro University of Michigan
Eric Delpire, PhD Vanderbilt University
Alexandra Urban, MD
Jon Rittenberg, MD, MS University of Pittsburgh Department of Emergency Medicine
Anto Bagic, MD, MS University of Pittsburgh Department of Neurology
Jullie Pan, MD, PhD University of Pittsburgh Department of Neurology
Arun Antony, MD University of Pittsburgh Department of Neurology
Rick Hendrickson, PhD University of Pittsburgh Department of Neurology
Maria Baldwin, MD University of Pittsburgh Department of Neurology
Gena Ghearing, MD University of Pittsburgh Department of Neurology
Mark Richardson, MD University of Pittsburgh Department of Neurosurgery
A. Ghuman, PhD University of Pittsburgh Department of Neurosurgery
Jonathan Elmer, MD University of Pittsburgh Department of Emergency Medicine
Anne Van Cott, MD
Mary Jo Pugh, RN, PhD University of Texas Health Science Center
Hoby Hetherington, MD University of Pittsburgh Amy Wagner, MD University of Pittsburgh
110
Zongqi Xia, MD, PhD -
Sergio Baranzini, PhD International Multiple Sclerosis Microbiome Study Consortium
Philip De Jager, MD, PhD Brigham and Women’s Hospital, Broad Institute
Daniel Reich, MD, PhD National Institute of Neurological Disorders and Stroke
Amar Dhand, MD, DPhil Brigham and Women’s Hospital
Guergana Savova, PhD Boston Children’s Hospital
Tianxi Cai, ScD Harvard School of Public Health
David Whitcomb, MD, PhD University of Pittsburgh, Department of Cell Biology and Physiology
Shyam Visweswaran, MD, PhD University of Pittsburgh, Department of Biomedical Informatics
Kayhan Batmanghelich, PhD University of Pittsburgh, Department of Biomedical Informatics
Joseph Mettenburgh, MD, PhD University of Pittsburgh, Department of Radiology
Ashok Panigraphy, MD University of Pittsburgh, Department of Radiology
Bennett Landsman, PhD Vanderbilt University
Brian Kolowitz, DSc, MSc, MBA University of Pittsburgh Medical Center Enterprise
Tingting Zhang, PhD Brown University
Helen Tremlett, PhD University of British Columbia
John Corboy, MD University of Colorado Denver
Darren Okuda, MD University of Texas Southwestern
Tamer Ibrahim, PhD Univeristy of Pittsburgh
Lawrence Wechsler, MD
Robert Hobson, MD University of Medicine and Dentistry New Jersey
Daniel Hanley, MD Johns Hopkins University
Paula Clemens, MD University of Pittsburgh School of Medicine Department of Neurology
Clifton Callaway, MD, PhD University of Pittsburgh School of Medicine Department of
Emergency Medicine
Maarten Lansberg, MD, PhD Stanford University Medical Center
Kejie Yin, MD, PhD
Eugene Chen, MD, PhD University of Michigan Vascular Medicine
Jun Chen, MD University of Pittsburgh Department of Neurology
Bruce A. Freeman, PhD University of Pittsburgh Department of Pharmacology
Naoir Zaher, MD
Arun Antony, MD Univeristy of Pittsburgh Department of Neurology
Alexandra Urban, MD University of Pittsburgh Department of Neurology
Islam Zaydan, MD
Robert Friedlander, MD University of Pittsburgh Department of Neurosurgery
Juan Fernandez-Miranda, MD University of Pittsburgh Department of Neurological Surgery
Gabrielle Bonhomme, MD University of Pittsburgh Department of Ophthalmology
Feng Zheng, MD, PhD
Jun Chen, MD University of Pittsburgh Department of Neurology
Guodong Cao, PhD University of Pittsburgh Department of Neurology
111
Yanqin Gao, PhD Fudan University State Key Lab of Neurobiology
R. Anne Stetler, PhD University of Pittsburgh Department of Neurology
Rehana K. Leak, PhD Duquesne University School of Pharmacy
Baoliang Sun, MD, PhD Tanshan Medical University
Richard F. Keep, PhD University of Michigan, Department of Neurosurgery
Xunming Ji, MD, PhD Xuanwu Hospital, Capital Medical University
Michael Zigmond, PhD
Judy Cameron, PhD University of Pittsburgh Department of Psychiatry
Barry Hoffer, PhD Case Western Reserve University
Jun Chen, MD University of Pittsburgh Department of Neurology
Jan Cavanaugh, PhD Duquesne University
Beth Fischer, PhD University of Pittsburgh Department of Family Medicine
Adrian Michael, PhD University of Pittsburgh Department of Chemistry
Karoly Mirnics, MD Vanderbilt University
Richard Smeyne, PhD St. Jude Children’s Hospital
Sasa Zivkovic, MD
Prem Soman, MD, PhD University of Pittsburgh, Division of Cardiology
Elsa Strotmeyer, PhD University of Pittsburgh Graduate School of Public Health
Michal Vytopil, MD, PhD Lahey Hospital and Medical Center, Burlington, MA
Ahmed El-Dokla, MD Texas Tech University
Suzanne Lentzsch, MD PhD Pittsburgh Cancer Institute
Elsa Strotmeyer, PhD University of Pittsburgh Graduate School of Public Health
112
Faculty Honors, Editorial Service, and Professional Affiliations
Puja Aggarwal, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Epilepsy Society
Arun Antony, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Epilepsy Society
Society for Neuroscience
Anto Bagic, MD, PhD
Editorial Service
Editorial Board Member: Journal of Clinical Neurophysiology
Ad hoc reviewer
American Journal of Neuroradiology Epilepsy & Behavior Brain Research Epilepsy Research
Case Reports in Neurology Journal of Neuroimaging
Clinical Neurophysiology Journal of Clinical Neurophysiology Croatian Medical Journal Seizure
Epilepsia
Membership in Professional and Scientific Societies
National and International
American Academy of Neurology (AAN)
American Clinical MEG Society (ACMEGS)
American Clinical Neurophysiology Society (ACNS)
American Epilepsy Society (AES)
American Medical Association
International Society for the Advancement of Clinical MEG (ISACM) Executive Committee
National Association of Epilepsy Centers, Board of Directors,
University and Medical School
Clinical Neurophysiology Fellowship Committee, Department of Neurology
Clinical Productivity Incentive Plan Committee, Department of Neurology
Clerkship Committee, Department of Neurology
Sarah Berman, MD, PhD
Honors
Selected Best Doctors of America 2017
Editorial Service
Ad hoc reviewer
American Journal of Pathology Journal of Neurochemical Research
Antioxidants & Redox Signaling Journal of Vestibular Research Autophagy Journal of Visualized Experiments
Biochimica et Biophysica Acta – Molecular Basis of Disease Mitochandrion
113
Cell Death and Differentiation Molecular Cell
Human Molecular Genetics Nature Reviews - Neuroscience
Journal of Biological Chemistry Neurobiology of Disease
Journal of Neurochemistry Neuroscience Journal of Neuroscience Neuroscience Letters
PLOS One
Membership in Professional and Scientific Societies
American Academy of Neurology
American Neurological Association
Movement Disorders Society
Parkinson Study Group
Society for Neuroscience
Edward Burton, MD, DPhil, FRCP
Honors
2017 Pittsburgh Magazine, Listed as one of the Top Doctors in the region for neurology
Editorial Service
Ad hoc reviewer
PLOS One
Brain Human Molecular Genetics
Neurobiology of Disease
The Journal of Neuroscience Reviewing Editor starting in 2015
The Journal of Biological Chemistry
Membership in Professional and Scientific Societies
American Neurological Association-Fellow
American Society for Biochemistry and Molecular Biology
Association of British Neurologists
Movement Disorders Society
Royal College of Physicians of London-Fellow
The Society for Neurosciences
Neil Busis, MD
Editorial Service
Editorial Board, Medscape Reference, Neurology (wwwURL:http://emedicine.medscape.com/neurology)
Editorial Board, Neurology Today
Ad hoc reviewer
Archives of Neurology Medscape General Medicine
Clinical Neurophysiology Muscle & Nerve
European Journal of Neurology Neurology
Journal of Neurology, Neurosurgery, and Psychiatry Neurology: Clinical Practice Journal of the American Medical Association The Neurologist
Journal of the Neurological Sciences
114
Memberships in Professional and Scientific Societies
Allegheny County Medical Society (PA)
American Academy of Neurology
American Association for the Advancement of Science
American Association of Neuromuscular & Electrodiagnostic Medicine
American Clinical Neurophysiology Society
American College of Physicians / American Society of Internal Medicine
American Medical Association
American Medical Informatics Association
Neurocritical Care Society
Neurohospitalist Society
PA Medical Society
PA Neurological Society
Stroke Council of the American Heart Association
Society for Neuroscience
The Internet Society
World Muscle Society
Franca Cambi, MD, PhD
Editorial Service
Grant Review
European Leukodystrophy Association (ELA Foundation)
Ministere de la Recherche, France
French National Research Agency (ANR)
National Multiple Sclerosis Society (NMSS)
National Science Foundation
Ad hoc reviewer
American Journal of Medical Genetics Journal of Neurological Sciences
Annals of Neurology Journal of Neuroscience
Current Medicinal Chemistry Journal of Pediatrics European Journal of Human Genetics Neurology
Experimental Journal of Human Genetics Plos One
Glia Human Mutation
Membership in Professional and Scientific Societies
American Academy of Neurology
American Society for Neurochemistry
Nominated American Neurological Association
Society for Neuroscience
Erin Canale, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Epilepsy Society
115
Guodong Cao, PhD
Editorial Service
Editorial Boards
Aging and Disease Annals of Neurological Surgery
Asian Journal of Neuroscience
Austin Aging Research Brain Circulation
Current Research in Stem Cell and Regenerative Medicine Geriatric Medicine & Palliative Care (GMPC)
International Journal of Neurology and Neurological Disorders
Journal of Cerebral Blood Flow and Metabolism Journal of eNeurologicalSci
Journal of Neurology and Experimental Neural Science
Neurological Disorders & Epilepsy Journal
Open Access Journal of Neurology
Prime Research in Neurological Disorders SM Neurodegenerative Disorders
SRL Brain Disorders & Therapy
Reviewer Committee, Neural Regeneration Research
Ad hoc reviewer
Advance in Neuroscience Annals of Neurology Neurobiology of Disease
Brain Research Neuroscience Letters
Cell Death and Differentiation Neurochemical International CNS Neuroscience and Therapeutics Neurochemical Research
Critical Care Medicine Neuropharmacology Drug Delivery Letters Neurochemistry International
European Journal of Pharmacology Neuroscience
Journal of Cerebral Blood Flow and Metabolism Neurotoxicity Research Journal of Neuroscience Pediatric Research
Journal of Neurochemistry PLOS One
Journal of Neurological Science Progress in Neurobiology Molecular Biology Reports Stem Cell
Neural Regeneration Research The Open Drug Discovery Scientific Report Translational Stroke Research
Molecular Therapy
Membership in Professional and Scientific Societies
International Society for Cerebral Blood Flow & Metabolism
Society for Neuroscience
Jun Chen, MD
Honors -
RK Mellon Endowed Chair for Cerebrovascular Disease Research, University of Pittsburgh 2008-
Sr Research Career Scientist Award, VA Medical Center
Changjiang Chair Professorship, Chinese Education Commission
Outstanding Oversea Researcher, Chinese Natural Science Foundation, China
116
Editorial Service
Editorial Board Member
Editor-in-Chief: Journal of Cerebral Blood Flow and Metabolism
Associate Editor, Translational Stroke Research Associate Editor, CNS Neuroscience & Therapeutics
Associate Editor and Handling Editor: Scientific Reports
Associate Editor and Handling Edior: Neurobiology of Disease CNS Neurological Disorders – Drug Targets
CNS Neurological Disorders – Clinical Drugs Journal of Cerebral Blood Flow and Metabolism
Neurobiology of Disease
Neurotherapeutics Progress in Neurobiology
Stroke Guest Editor and handling: Special Issue in Progress in Neurobiology
Guest Editor and handling: Special Issue in Neurobiology of Disease
Ad hoc reviewer American Journal of Pathology
Annals of Neurology
Bio Techniques Brain Research
Cell Death and Differentiation Circulation
Circulation Research
European Journal of Neuroscience European Journal of Pharmacology
Experimental Neurology Gene Therapy
Glia
Journal of Biological Chemistry Journal of Cell Biology
Journal of Cerebral Blood Flow and
Metabolism Journal of Clinical Investigation
Journal of Neurochemistry
Journal of Neuroscience
Molecular Brain Research Molecular Neurobiology
Molecular Therapy Nature Medicine
Nature Neuroscience
Neurobiology of Aging Neurobiology of Disease
Neurochemistry International Neuroscience
Neuroscience Letters
Neuroscience Research Nucleotide Acid Research
PNAS USA
Progress in Neurobiology Stroke
Membership in Professional and Scientific Societies -
American Heart Association Stroke Counsul
International Society for Cerebral Blood Flow and Metabolism
International Society of Translational Stroke Research
Society for Neuroscience
Professional Affiliations
Treasurer, International Society of Cerebral Blood Flow & Metabolism
Paula Clemens, MD
Editorial Service
Ad hoc reviewer
American Journal of Human Genetics Molecular Therapy Annals of Neurology Muscle & Nerve
BBA Molecular Basis of Disease Nature Biotechnology
117
Gene Therapy Neurology
Genome Research Neuroscience
Human Gene Therapy PLOS One Journal of Genetic Counseling Science Translational Medicine
Journal of Neurological Sciences The Journal of Gene Medicine
Kidney International Lancet Neurology
Membership in Professional and Scientific Societies
American Academy of Neurology
American Neurological Association
James DeMatteis, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Society of Neuro Rehabilitation
John Doyle, MD
Honors
Honored at the Honors Convocation University of Pittsburgh for Leadership in Medical Education 2017
Membership in Professional and Scientific Societies
American Academy of Neurology
Jan Drappatz, MD
Honors
Above and Beyond Award, UPMC, 2016
Best Doctors, 2017
Best of Pittsburgh, 2017
Castel Connolly Top Doctors, 2017
Compassionate Caregiver Award, Vitals, 2016
Editorial Service
Abstract Reviewer – Society of Neuro-Oncology Meeting
Ad Hoc Reviewer-
BMC Cancer International Journal of Radiation Oncology, Biology,
British Journal of Cancer Physics
Clinical Cancer Research Journal of Clinical Oncology Drug Discovery Today Journal of Neuro-Oncology
Drug Target Insights Medical Science Monitor Expert Reviews of Anticancer Therapy Neuro-Oncology
Future Oncology Neuropsychiatric Disease and Treatment
Membership in Professional and Scientific Societies-
Alliance for Clinical Trials in Oncology
American Academy of Neurology
American Association for Cancer Research
American Society of Clinical Oncology
International Primary Central Nervous System Lymphoma Collaborative Group
Society for Neuro-Oncology
118
Jeffrey Esper, DO, MS, (Med Ed)
Membership in Professional and Scientific Societies
American Association of Neuromuscular and Electrodiagnostic Medicine, Fellow
American College of Osteopathic Neurology and Psychiatry
Joanna Fong, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Academy of Sleep Medicine
American Epilepsy Society
Kathy Gardner, MD
VAPHS Service
Scan Echo Project for Headache Teaching Slides
Joint Pain Education Program/Defense & Veterans Center for Integrative Pain Management; Tier 2
teaching slides and headache expert reviewer
VA Women’s Health Choosing Wisely Taskforce member developing headache teaching slides
Membership in Professional and Scientific Societies
American Academy of Neurology
American Headache Society
American Society of Human Genetics
International Headache Society
Society of Neuroscience
Gena Ghearing, MD
Editorial Service
Ad hoc reviewer
Epilepsia
International Journal of Neural Systems
Neurology
Membership in Professional and Scientific Societies
Allegheny County Medical Society
American Academy of Neurology
American Clinical Neurophysiology Society
American Epilepsy Society
American Medical Association
Pennsylvania Medical Association
Steven Graham, MD, PhD
Editorial Service
Editorial Board
J. Cerebral Blood Flow and Metabolism
119
Ad hoc reviewer
Annals of Neurology Molecular Brain Research
Brain Research Molecular Neurobiology Brain Pathology Neurobiology of Disease
European Journal of Neuroscience Neuroscience
Experimental Neurology Neuroscience Letters F.A.S.E.B. Journal Neurochemical Research
Gene Therapy Neurochemistry International
Journal of Histochemistry and Cytochemistry Progress in Neurobiology Journal of Neurochemistry Stroke
Journal of Neuroscience Journal of Neurotrauma
Journal of Pharmacology and Experimental Therapeutics
Grant Review -
National Institute of Health, Center for Scientific Review, BINP Study Section
Membership in Professional and Scientific Societies
American Academy of Neurology, Stroke Council
Gerontological Society of America
National Stroke Council, American Heart Association
Society for Neuroscience
Erica Grazioli, DO
Membership in Professional and Scientific Societies
American College of Osteopathic Neurologists and Psychiatrists
American Academy of Neurology
American Osteopathic Association
Consortium of Multiple Sclerosis Centers
J. Timothy Greenamyre, MD, PhD
Honors
Listed, Top Doctors in Pittsburgh, Castle Connolly 2017
Listed, Best Doctors in America 2017
Chair, Gordon Research Conference on Parkinson’s disease
Editorial Service
Editor-in-Chief, Neurobiology of Disease Editor-in-Chief, Medlink Neurology (www.medlink.com) online clinical resource
Consulting Editor for Journal of Clinical Investigation
Advisory Board, Functional Neurology Reviewing Editor, ASN-Neuro
Editorial Board, Journal of Parkinson’s Disease
Editorial Board, Neuropharmacology
Editorial Board, Basal Ganglia
Interspecialty Associate Editor, Neurosurgery
120
Ad hoc reviewer
American Journal of Human Genetics Journal of Neuroscience
American Journal of Physiology Journal of Neuroscience Research Annals of Neurology Journal of Neurophysiology
Archives of Neurology Journal of the Neurological Sciences
Behavioral Pharmacology J. Pharmacology and Experimental Therapeutics Biochemical Pharmacology The Lancet
Biochim Biophys Acta Life Sciences
Biological Psychiatry Mechanisms of Aging and Development Brain Molecular and Chemical Neuropathology
Brain Pathology Molecular Pharmacology Brain, Behavior and Immunity Molecular Therapeutics
Brain Research Movement Disorders
Cell Nature Cell Metabolism Nature Medicine
Clinical Neuropharmacology Nature Neuroscience
EMBO Molecular Medicine Neurobiology of Aging
Endocrinology Neurobiology of Disease
Epilepsy Research Neurodegeneration European Journal of Neuroscience Neurology
Experimental Brain Research Neuron
Experimental Neurology Neuropharmacology Free Radical Biology & Medicine Neuroscience
Human Molecular Genetics Neuroscience Letters Journal of Alzheimer’s Disease Neuro Toxicology
Journal of Biological Chemistry Parkinson’s Disease
Journal of Cell Science Physiology & Behavior Journal of Cerebral Blood Flow and Metabolism Proc. Natl. Acad. Of Science (U.S.A.)
Journal of Clinical Investigation Psychobiology Journal of Comparative Neurology Science
Journal of Experimental Medicine Science Translational Medicine
Journal of Neural Transmission Trends in Molecular Medicine Journal of Neurochemistry Trends in Pharmacological Sciences
Nature Reviews Neuroscience Analytical Chemistry
Cell Research
Ad hoc Grant Reviews
Alzheimer’s Association
Medical Research Council of Canada
Hereditary Disease Foundation
Huntington’s Disease Society of America
The Ontario Mental Health Foundation (Canada)
Alberta Heritage Foundation for Medical Research
U.S. Army / BioReview (NETRP-97)
North Carolina Biotech Center Science and Technology Development Program
Parkinson’s Disease Society, London, UK
121
Membership in Professional and Scientific Societies -
American Academy of Neurology
American Neurological Association
Association of American Physicians
Huntington Study Group
Movement Disorders Society
Parkinson Study Group
Society for Neuroscience
Maxim Hammer, MD
Editorial Service
Ad Hoc Reviewer
Stroke
Membership in Professional and Scientific Societies
American Academy of Neurology
American Heart Association Stroke Council
Teresa Hastings, PhD
Editorial Service
Handling Editor, Editorial Board Member for Journal of Neurochemistry
Editorial Board Member for Experimental Neurology
Ad hoc reviewer
Biochimica et Biophysica Acta Journal of Neurochemistry Experimental Neurology Journal of Neuroscience
Free Radical Biology and Medicine Neurobiology of Disease
Journal of Neurochemistry
Membership in Professional and Scientific Societies
American Academy for Advancement of Science
International Society for Neurochemistry
New York Academy of Sciences
Society for Free Radical Biology and Medicine
Society for Neuroscience
Rock Heyman, MD
Honors/Recognition
Best Doctors in America, Woodard/White, Inc.
Membership in Professional and Scientific Societies
American Academy of Neurology, Multiple Sclerosis Section
Consortium of Multiple Sclerosis Centers
Editorial Service
Ad hoc reviewer
International Journal of MS Care
122
Houman Homayoun, MD
Editorial Service
Ad hoc Reviewer
Brain Research Bulletin Neuropsychopharmacology Biological Psychiatry Neuroscience
International Journal of Neuropsychopharmacology Neuropharmacology Journal of Pharmacology and Experimental Therapeutics Psychopharmacology
Neurobiology of Disease
Membership in Professional and Scientific Societies
American Academy of Neurology
International Parkinson and Movement Disorder Society
Parkinson Study Group
Society for Neuroscience
Xiaoming Hu, MD, MS, PhD
Membership in Professional and Scientific Societies
American Heart Association
American Neurological Association
Society for Neuroscience
The International Society of Cerebral Blood Flow and Metabolism
Editorial Board
Journal of Clinical & Experimental Neuroimmunology
Editorial Service
Ad hoc reviewer
Annals of Neurology Journal of Neuroinflammation
Brain Research Neurobiology of Disease
CNS Neuroscience & Therapeutics Nutrition Research Journal of Cell & Molecular Medicine Stroke
Journal of Neuroinflammation The Journal of Cerebral Blood Flow & Metabolism
Translational Stroke Research Pro Natinal Academic Sci USA
Reviewer:
Internaitonal Symposiium on Cerebral Blood Flow, Metabolism and Function
Internaional Stroke Conference
Milos Ikonomovic, MD
Honors
January 2017 received The Christopher Clark Award – for continuing advancement in the field of human
amyloid imaging
Editorial Service
Associate Editor - Cardiovascular Psychiatry and Neurology
Review Editor - Neurotrauma
123
Ad hoc reviewer
Acta Neuropathologica Journal of Gerontology
Alzheimer’s & Dementia Journal of Neuropathology & Exper Neurol American Journal of Pathology Journal of Neurotrauma
Alzheimer Disease and Associated Disorders Nature
Annals of Neurology Neurobiology of Aging Archives of Neurology Neurotrauma
Brain Neurimage Clinical
Experimental Neurology Neurology Frontiers in Neurology Neuroscience
Journal of Alzheimer’s Disease PNAS Journal of Comparative Neurology
Grant reviewer
The Alzheimer’s Association International Research Grant Program
University of Pittsburgh Alzheimer Disease Research Center pilot grant review
Department Psychiatry Internal Review
VA Geriatric Research Education and Clinical Center (GRECC) Scientific Review
Membership in Professional and Scientific Societies
American Academy of Neurology
International Society to Advance Alzheimer Research and Treatment
National Neurotrauma Society
New York Academy of Sciences
Researchers Against Alzheimer’s
Society for Neuroscience & International Brain Research Organization
Ashutosh Jadhav, MD, PhD
Editorial Service
Associate Editor – Society for Vascular and Interventional Neurology Newsletter
Abstract Reviewer
American Stroke Association, International Stroke Conference
Ad hoc reviewer
Canadian Journal of Neurology
Journal of Neuroimaging Journal of Neurointerventional Surgery
The Neurologist
Membership in Professional and Scientific Societies
American Academy of Neurology
American Stroke Association
Society of Vascular and Interventional Neurology
Samay Jain, MD
Editorial Service
Guest Editor
Neurobiology of Disease
124
Ad Hoc Grant Reviews
VISN 4 Competitive Pilot Project Fund Medical Research Council
Western Psychiatric Institute and Clinic Research Committee
Editorial Board
The Neurohospitalist
Journal of the American Geriatrics Society Ad hoc reviewer
Case Reports and Clinical Practice Review Journal of American Geriatrics Society
Clinical Neurology and Neurosurgery Journal of Pediatric Neurology European Journal of Neurology Movement Disorders
Expert Review of Neurotherapeutics The American Journal of Managed Care International Journal of Psychophysiology The Neurohospitalist
Tremor & Other Hyperkinetic Movements Neuropsychiatric Disease and Treatment
Journal of Parkinson’s Disease Journal of Gerontology: Medical Sciences Journal of Parkinsonism & Restless Leg Syndrome Journal of Visualized Experiments
Journal of Geriatric Psychiatry and Neurology Journal of Human Hypertension
Journal of Neurology, Neurosurg & Psychiatry Parkinsonism & Related Disorders
Acta Neruologica Scandinavica Expert Opinion On Investigational Drugs
Membership in Professional and Scientific Societies
American Academy of Neurology
Movement Disorders Society
Ruchira Menka Jha, MD
Memberships in Professional and Scientific Societies
American Academy of Neurology
American Heart Association
Massachusetts Medical Society
Neurocritical Care Society
Society of Critical Care Medicine
Society for Neuroscience
Tudor Jovin, MD
Honor
Society of Vascular and Interventional Neurology Presidential Service Award
Editorial Service
Member, Editorial Board, Journal of Neuroimaging
Member, Editorial Board, Stroke
Member, Editorial Board, Interventional Neurology
Ad hoc reviewer Annals of Neurology Lancet Neurology
Circulation Neurology Journal of Endovascular Therapy Neurosurgery
Journal of Neuroimaging NINDS grant submissions
Journal of Neurointerventional Surgery Stroke Journal of Neurology Neurosurgery and Psychiatry
125
Membership in Professional and Scientific Societies
American Academy of Neurology
American Association of Neurological Surgeons
American Heart Association – Stroke Council
American Neurological Association
American Society of Neuroimaging
Society of Vascular and Interventional Neurology
World Stroke Organization
Robert Kaniecki, MD
Editorial Service
Assistant Editor, Headache Abstracts Editor, Headache
Ad hoc reviewer
Cephalalgia
Membership in Professional and Scientific Societies
American Academy of Neurology
American Headache Society
International Headache Society
Kelly Kay, DO
Membership in Professional and Scientific Societies
American Academy of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
Pennsylvania Medical Society
Allegheny County Medical Society
Simin Khavandgar, MD
Membership in Professional and Scientific Societies
American Association of Sleep Medicine
American Academy of Neurology
Daniel Kinem, DO
Membership in Professional and Scientific Societies
American Academy of Neurology
American Osteopathic Association
Laurie Knepper, MD
Honors
2017 - Castle Connolly – Exceptional Women in Medicine
Best Doctors in Pittsburgh, Pittsburgh Magazine – 2017
Editorial Service
Reviewer - Journal of Stroke and Cerebrovascular Diseases Ad hoc Reviewer
Headache
126
Membership in Professional and Scientific Societies
American Academy of Medical Colleges (AAMC)
American Academy of Neurology
Headache subsection
Stroke subsection
American Headache Society
EMR/clinical informatics subsection
Headache Cooperative of New England
International Headache Society
David Lacomis, MD
Honors
“Top Doctors,” Pittsburgh Magazine, 2016
“America’s Top Doctors,” Castle Connolly Medical Ltd., 2016
“Best Doctors in America” (Woodward/White, Inc.), 2016
“America’s Most Honored Professionals Award – Top 5%,” American Registry, 2016
Editorial Service
Member, Editorial Board, Journal of Clinical Neuromuscular Diseases Section Editor, “What’s in the Literature?” Journal of Clinical Neuromuscular Diseases
Ad hoc reviewer:
Annals of Neurology Muscle and Nerve
Neurology
Membership in Professional and Scientific Societies -
American Academy of Neurology, Active Member, Fellow
American Association of Electrodiagnostic Medicine, Fellow
American Neurological Association, Fellow
Erek Lam, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Academy of Sleep Medicine
Mayo Clinic Alumni Association
Frank Lieberman, MD
Editorial Service
Ad hoc reviewer
Annals of Neurology Cancer Chemotherapy and Pharmacology
Clinical Cancer Research Journal of Neuroimaging
Lancet
Membership in Professional and Scientific Societies
American Association of Cancer Research
American Academy of Neurology – Neuro-Oncology Section
127
American Society of Clinical Oncology
Collaborative Ependymoma Research Network
ECOG-ACRIN: Biomarker Committee – CNS Tumor Committee
Radiation Therapy Oncology Group-CNS Tumors Committee
Society for Neuro-Oncology
Hao Liu, MD, PhD
Editorial Service
Ad hoc reviewer
Journal of Neuroscience Methods
PLOS One
Membership in Professional and Scientific Societies
American Society for Biochemistry and Molecular Biology (ASBMB)
International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
Society for Neurosciences (SFN)
Oscar Lopez, MD
Honors
Endowed Chair: Levidow-Pittsburgh Foundation Endowed Chair in Alzheimer’s Disease and Dementia
Disorders
Honoree, University of Pittsburgh 41st Honors Convocation (2017)
Pittsburgh Magazine; Best Doctors in Town, Pittsburgh, PA (2017)
Editorial Service
Editorial Board, Neuropsychology Review, Associate Editor
Alzheimer’s & Dementia Translationa Research & Clinical Interventions
Alzheimer’s and Dementia. The Journal of the Alzheimer’s Association
European Neruology, Basel, Switzerland
Ad hoc reviewer
Alzheimer’s & Dementia
Annals of Neurology Biological Psychiatry
Circulation: Cardiovascular Quality & Outcomes
Cochrane DTA Human Brain Mapping
International Journal of Geriatric Psychiatry JAMA-Neurology
Journal of Alzheimer’s Disease
Journal of the American Geriatrics Society Lancet-Psychiatry
Nature: Scientific Reports
Neurobiology of Aging
Neurology
The American Journal of Psychiatry
128
Ad Hoc Grant Reviewer National Fund for Scientific and Technological Development (Fondo Nacional para el Desarrollo
Científico y Tecnológico -FONDECYT), Santiago, Chile
Vienna Science and Technology Fund (Wiener Wissenschafts- Forschungs- und
Technologiefonds), Vienna, Austria
National Agency of Research (Agence Nationale de la Récherche), Paris, France
The German Federal Ministry for Education and Research (BMBF), Berlin, Germany
NIH-National Institute on Aging – Neuroscience of Aging Review Committee
Angela Lu, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
Lazarus Mayoglou, DO
Membership in Professional and Scientific Societies
American Academy of Neurology
American Clinical Neurophysiology Society
American Epilepsy Society
American Osteopathic Association
James McLaughlin, DO, FACP, FAAN, FAHA
Honors
American Stroke Association/American Heart Association get with the guideline awards -Honor Roll
Elite Plus & Gold Plus – 2017
Memberships in Professional and Scientific Societies
American Academy of Neurology
American College of Physicians Fellowship
American Telemedicine Association
National Stroke Association
Edward Mistler, DO
Membership in Professional and Scientific Societies
American Academy of Neurology
American Osteopathic Association
Pennsylvania Medical Society
Bradley Molyneaux, MD, PhD
Editorial Service
Ad hoc reviewer
Journal of Neuroscience
129
Membership in Professional and Scientific Societies
American Academy of Neurology
American Heart Association
Neurocritical Care Society
Society for Neuroscience
Society of Critical Care Medicine
Dimitrios Nacopoulos, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
Movement Disorders Society
Parkinson’s Partners of Northwest PA, Medical Director
UPMC-Hamot Neurology Residence Assistant Director
Eric Ogren, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
Ajitesh Ojha, MD
Membership in Professonal and Scientific Societies
American Association of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
The Neurophospitalist Society
Jullie Pan, MD, PhD
Editorial Service
Editorial Board - Magnetic Resonance in Medicine
MAGMA Journal of the European Society for Magnetic Resonance in Medicine and Biology
Membership in Professional and Scientific Societies
American Academy of Neurology
American Epilepsy Society
International Society for Magnetic Resonance in Medicine
International Society for Cerebral Blood Flow and Metabolism
Society for Neuroscience
Araya Puwanant, MD
Honors
NINDS Clinical Trail Methodology Course Award
Editorial Service
Ad hoc review
European Journal of Neurology European Neurology
Journal of the Neurological Sciences
International Journal of Neuroscience
130
Membership in Professional and Scientific Societies
American Academy of Neurology
American Association of Neuromuscular & Electrodiagnostic Medicine
American Neurological Society
New York Academy of Sciences
Vivek Reddy, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American College of Physician Executives
American Heart Association/American Stroke Association
American Medical Informatics Association
Association of Medical Directors of Information Systems
Marcelo Rocha, MD, PhD
Editorial Service
CNS Neuroscience & Therapeutics
Membership in Professional and Scientific Societies
American Academy of Neurology
American Stroke Association/AHA
Jingzi Shang, MD, PhD
Memberships in Professional and Scientific Societies
American Academy of Neurology
American Academy of Sleep Medicine
Pennsylvania Medical Society
Lori Shutter, MD, FCCM
Editorial Service
Periodicals
Critical Care Medicine Neurosurgery
Journal of Neurosurgery, Neurology and Psychiatry Neurocritical Care
Journal of Critical Care New England Journal of Medicine Journal of Neurotrauma
Membership in Professional and Scientific Societies
American Medical Association
American Academy of Neurology
National Neurotrauma Society
Neurocritical Care Society (NCS)
Congress of Neurological Surgeons
American Association of Neurological Surgeons
Society of Critical Care Medicine
Gold Humanism Honor Society
Western Neurosurgical Society
Women in Neurosurgery
131
Stuart Silverman, MS, MD, FAAN
Membership in Professional and Scientific Societies
Allegheny County Medical Society
American Academy of Neurology
American Society of Neuroimaging
Pennsylvania Medical Society
Pittsburgh Neuroscience Academy
Beth Snitz, PhD
Editorial Service
Editorial Board Member: Journal of the American Geriatrics Society (JAGS)
Ad hoc reviewer
Aging and Mental Health Journal of Alzheimer’s Disease
Alzheimer’s and Dementia Journal of Applied Gerontology
Biological Psychiatry Journal of Clinical and Experimental Neuropsychology
Gerontology Journal of the International Neuropsychological Society
Health Psychology Neuropsychology International Psychogeriatrics Personality and Neuroscience
JAMA Neurology Psychology and Neuroscience
Journal of the American Geriatric Society Schizophrenia Research Current Alzheimer Research
Grant Reviewer
Internal Reviewer, Department of Psychiatry Grant Review Committee, University of Pittsburgh
Membership in Professional and Scientific Societies
American Psychological Association
International Neuropsychological Society
Arthur Sonberg, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Association of Neuromuscular & Electrodiagnostic Medicine
Josif Stakic, MD
Editorial Service
Ad hoc reviewer
Headache journal
Membership in Professional and Scientific Societies
American Academy of Neurology
American Headache Society
Matthew Starr, MD
Editorial Service
Reviewer for abstracts for International Stroke Conference for 2016-17
132
Membership in Professional and Scientific Societies
American Academy of Neurology
American Heart Association
Ruth Anne Stetler, PhD
Editorial Service
Ad hoc reviewer
Brain Research Journal of Neurochemistry Brain Research Bulletin Journal of Neuroscience
CNS Neuroscience & Therapeutics Journal of Neuroscience Research
CNS & Neurological Disorders-Drug Targets Leukemia eNeuro Neurochemistry International
International Journal of Biological Sciences Recent Patents on CNS Drug Discovery Journal of Cerebral Blood Flow and Metabolism Translational Stroke Research
Leukotrienes & Essential Fatty Acids Prostaglandins
Membership in Professional and Scientific Societies
American Heart Association
International Society for Cerebral Blood Flow and Metabolism
Society for Neuroscience
Michelle Stevens, DO
Membership in Professional and Scientific Societies
American Association of Electrodiagnostic Medicine
American Board of Osteopathic Neurologissts and Psychologists
American Osteopathic Association
Dandan Sun, MD, PhD
Honors
Endowed Chair Professor in the Department of Neurology UPMC
Faculty Sponsor for Brackenridge Undergraduate Research Fellowship at University of Pittsburgh
Faculty Sponsor for American Heart Association Postdoc Fellowship Awardee Dr. Shanshan Song
Editorial Service
Editorial Board Member
Frontiers in Membrane Physiology
International Journal of Physiology, Pathophysiology and Pharmacology
Grant Review
Welcome Trust Research
Ad hoc reviewer – National Science Foundation grants
Journal of Cerebral Blood Flow and Metabolism Neurology
Journal of Neurochemistry Stroke
Journal of Neuroscience
Membership in Professional and Scientific Societies
American Physiological Society
Society for the Cerebral Blood Flow, Metabolism & Function
Society of the Chinese Bioscientists in America
Society for Neuroscience
133
Valerie Suski, DO
Honors
Pittsburgh Magazine Best Doctors List 2017
Membership in Professional and Scientific Societies
American Academy of Neurology
American Medical Association
American Osteopathic Association
Huntington’s Study Group
Movement Disorders Society
Parkinson’s Study Group
Alexandra Urban, MD
Honors
UPMC Neurology Residents Excellence in Didactic Teaching Award, 2017
Membership in Professional and Scientific Societies
American Academy of Neurology
American Epilepsy Society
Anne Van Cott, MD
Honor
2017 – Best Doctors (Neurology), Pittsburgh Magazine
Editorial Service
Ad hoc reviewer
Aging Health Journal of Neurology
Epilepsia Journal of Rehabilitation Research and Development
Epilepsy and Behavior Pharmacoepidemiology and Drug Safety
Epilepsy Research The American Journal of Geriatric Pharmacotherapy
Hospital Physician Epilepsy Board Review Manual
Research Centers for Disease Control and Prevention Special Emphasis Panel
Epilepsy Foundation of America’s Targeted Research Initiative for Seniors
VA Healthcare Network VISN 4 Competitive Pilot Project Fund (CPPF)
Membership in Professional and Scientific Societies
American Academy of Neurology
American Clinical Neurophysiology Society
American Epilepsy Society
Barbara Vogler, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Headache Society
134
Janet Waters, MD, MBA
American Academy of Neurology
Zongqi Xia, MD, PhD
Honors
September 2016 – Best poster award at the 32nd congress of the European Committee for Treatment
Research in Multiple Sclerosis (ECTRIMS) in London UK.
Editorial Board Member
Neuroimmunology and Neuroinflammation
Ad Hoc Reviewer
American Medicl Informatics Association Journal of Neurological Sciences
Annals of Neurolgy Multiple Sclerosis Journal
Arthritis Care and Research Neurology
Genes and Immunity
Membership in Professional and Scientific Societies
American Academy of Neurology
American Neruological Association
Janet Waters, MD
Editorial Service
Co-editor of textbook: Neurological Illness in Pregnancy: Principles and Practice
Membership in Professional and Scientific Societies
American Academy of Neurology
Lawrence Wechsler, MD
Editorial Service
Editor-in-Chief, Frontiers in TeleNeurology
Associate Editor, Translational Stroke Research
Editorial Board, Circulation Editorial Board, Stroke and Vascular Neurology
Ad hoc reviewer
Annals of Neurology New England Journal of Medicine
Neurology Stroke
Membership in Professional and Scientific Societies
American Academy of Neurology
American College of Physicians
American Medical Association
American Neurological Association
American Society of Neuroimaging
Society for Neuroscience
135
Claire Yanta, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Headache Society
Kejie Yin, MD, PhD
Honors
The Investigator Award, European Stroke Research Foundation
Editorial Service
Editorial Board Member
ARC Journal of Neuroscience (AJNS) Austin Neurology
Journal of Stroke Research
World Journal of Neuroscience
Ad Hoc Reviewer
Aging and Disease CNS Neuroscience & Therapeutics
Experimental Neurology
Metabolic Brain Disiease Nature Communications
Nature Methods Neurochemistry Internaitonal
Neuroscience Letters
PPAR Research Progress in Neurobiology
Translational Stroke Research
Membership in Professional and Scientific Societies
American Heart Association/American Stroke Association
International Society of Cerebral Blood Flow and Metabolism (ISCBFM)
Society for Neuroscience
Naoir Zaher, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
American Medical Association
American Clinical Neurophysiology Society
Islam Zaydan, MD
Membership in Professional and Scientific Societies
American Academy of Neurology
North American Neuro-Ophthalmologic Society
136
Feng Zhang, MD, PhD
Editorial Services
Editorial Board
NS & Neurological Disorders-Drug Targets (CNSND-DT) Austin Journal of Cerebrovascular Disease & Stroke
Grant Reviewer, National Science Foundation of China Ad hoc reviewer
Brain Research Molecular Neurobiology
Clinical Pharmacology & Biopharmaceutics Neurological Research CNS Neuroscience & Therapeutics Neuroscience
Journal of Visualized Experiments Pharmacology
Mini-review of Medical Chemistry Plos One Metabolic Brain Disease Translational Stroke Research
Molecular Biology Reports Scientific Reports Vascular Health and Risk Management
Membership in Professional and Scientific Societies
American Heart Association/American Stroke Association
International Society of Cerebral Blood Flow and Metabolism
Society for Neuroscience
Michael Zigmond, PhD
Editorial Service
Editor-in-Chief - Progress in Neurobiology
Ad hoc reviewer
The Open Ethics and Law Journal JUNE (Journal of Undergraduate Research Education) Neurology Research International Biology Image Library, Neuroscience Section
Neuroscience Bulletin Behavioral and Brain Functions
Engineering & Science Ethics
Membership in Professional and Scientific Societies
American Association for the Advancement of Science
American Society for Pharmacology and Experimental Therapeutics
International Brain Research Organization
New York Academy of Science
Sigma Xi
Society for Neuroscience
Saša Živković, MD, PhD
Editorial Service
Member, Editorial Advisory Board, World Journal of Hepatology
Grant Reviewer, Central Research Fund, University of Pittsburgh
Ad hoc reviewer
Acta Neurologica Scandinavica
Muscle Nerve Neurology
Transplantation Transplant International
137
Membership in Professional and Scientific Societies
ALS Research Group
American Academy of Neurology
American Association of Neuromuscular and Electrodiagnostic Medicine
Inflammatory Neuropathy Consortium (INC)
North East ALS Consortium (NEALS)
Peripheral Nerve Society
138
139
Members of the Faculty 2016-2017
Arun Antony, MD Assistant Professor
Anto Bagić, MD, PhD Associate Professor
Sarah Berman, MD, PhD Assistant Professor
Edward A. Burton, MD, DPhil, FRCP Associate Professor
Neil Busis, MD Clinical Professor
Guodong Cao, PhD Associate Professor
Jun Chen, MD Professor
Sherry Chou, MD, MSc, FNCS Visiting Associate Professor
Paula R. Clemens, MD Professor
James DiMatteis, MD
John J. Doyle, MD Associate Professor
Jan Drappatz, MD Associate Professor
Jeffrey Esper, DO Clinical Professor of Internal Medicine
Joanna Fong, MD Clinical Assistant Professor
Kathy Gardner, MD Assistant Professor
Gena Ghearing, MD Assistant Professor
Steven H. Graham, MD, PhD Professor
J. Timothy Greenamyre, MD, PhD Professor
Erica Grazioli, DO
Maxim Hammer, MD Associate Professor
Teresa G. Hastings, PhD Associate Professor
Rick Hendrickson, PhD Assistant Professor
Rock A. Heyman, MD Associate Professor
Eric Hoffman, PhD Research Assistant Professor
Houman Homayoun, MD Assistant Professor
Xiaoming Hu, MD Research Assistant Professor
Milos Ikonomovic, MD Associate Professor
Ashutosh Jadhav, MD Assistant Professor
Samay Jain, MD Assistant Professor
Ruchira Menka Jha, MD Clinical Instructor
Tudor Jovin, MD Associate Professor
Robert Kaniecki, MD Assistant Professor
Kelly Kay, DO Clinical Assistant Professor
Simin Khavandgar, MD Clinical Assistant Professor
Daniel Kinem, DO Neurohospitalist
Laurie Knepper, MD Associate Professor
David Lacomis, MD Professor
Erek Lam, MD Clinical Assistant Professors
Frank Lieberman, MD Professor
140
Guillermo Linares, MD Clinical Instructor
Hao Liu, PhD Research Assistant Professor
Oscar L. Lopez, MD Professor
Angela Lu, MD Clinical Assistant Professor
Lazarus Mayoglou, DO Clinical Assistant Professor
Edward Mistler, DO Clinical Assistant Professor
Bradley Molyneaux, MD, PhD Assistant Professor
Eric Ogren, MD Assistant Professor
Ojha, AJ, MD Clinical Assistant Professor
Jullie Pan, MD, PhD Professor
Vivek Reddy, MD Assistant Professor
Marcelo Rocha, MD Assistant Professor
Jingzi Shang, MD
Lori Shutter, MD Professor
Stuart Silverman, MD Clinical Associate Professor
Beth Snitz, PhD Assistant Professor
Josif Stakic, MD Assistant Professor
Matthew Starr, MD Assistant Professor
Ruth Ann Stetler, PhD Research Assistant Professor
Michelle Stevens, DO
Dandan Sun, MD, PhD Professor
Valerie Suski, DO Assistant Professor
Alexandra Urban, MD Assistant Professor
Anne Van Cott, MD Associate Professor
Amber Van Laar, MD Instructor
Barbara Vogler, MD Clinical Assistant Professor
Janet Waters, MD, MBA Clinical Assistant Professor
Lawrence Wechsler, MD Professor and Chair
Islam Zaydan, MD Assistant Professor
Michael Zigmond, PhD Professor
Saša Živković, MD Associate Professor
New Faculty Members
Faculty Member Previous Appointment
Brown, Merritt, MD University of PA Health System
Neurocritical Care Fellow
Erin Canale, MD Mount Carmel Mecial Group
General Neurologist
Cynthia Kenmuir, MD UPMC
Neuroendovascular Fellow
141
Karuna Mandava, MD Excela Health Systems
Private Neurology Practice
Robyn Massa, MD UPMC
Neurology Residency
Ajetesh Ojha, MD UPMC
Clinical Neurophysiology Fellow
Cosmin Sandulescu, MD Albert Einstein Medical Center
Neurology Residency
Arthur Sonberg, MD Carteret Medical Group
Neurologist
Ahmed Yassin, MD UPMC
Clinical Neurophysiology/EEG Fellow
Faculty Departures
Faculty Member New Position and Rank
Gena Ghearing University of Iowa. Iowa
Clinical Associate Professor
Vivek Reddy
Inter-Mountain Health Care, Salt Lake City, Utah
Chief Health Information Office
Puja Aggarwal Private Practice
Clinical Education 2016-2017
House Officers
PGY 4 Co-Chief Residents Medical Education
Brian Hanrahan, MD State University of New York Upstate Medical University
Eric Jackowiak, MD Indiana University School of Medicine
Jodi Manners, MD University of Pittsburgh School of Medicine
PGY 4 Residents
Kiruba Dharaneeswaran, MD Pennsylvania State University College of Medicine
Natalia Gonzales, MD Pennsylvania State University College of Medicine
James Lee, MD, PhD University of Illinois College of Medicine
Deepak Soneji, MD University of Pittsburgh School of Medicine
PGY 3 Residents
Kevin Elmore, MD University of Illinois College of Medicine
142
Michael Isfort, MD
Ohio State University College of Medicine
Christina Kyrtsos, MD Penn State University College of Medicine
Pouria Moshayedi, MD, PhD Tehran University of Medical Sciences
Sherya Nayak, MD Ohio State University College of Medicine
Madison Pilato, MD University of Rochester School of Medicine & Dentistry
Ying Sun, MD Chicago Medical School at Rosalind Franklin University of Medicine
& Science
PGY 2 Residents
Yasmin Aziz, MD Drexel University College of Medicine
Adam Barron, MD Medical College of Wisconsin
Lauren Brandes, MD Emory University School of Medicine
Devin Burke, MD State University of NY Upstate Medical University
Steven Gangloff, MD State University of New York At Buffalo of Medicine
Michael Korsmo, MD Tulane University School of Medicine
Xiaowei (Bill) Su, MD, PhD Pennsylvania State University College of Medicine
PGY 1 Residents
Paige Banyas Lake Erie College of Osteopathic Medicine, Erie
Preeya Fozdar University of Virginia School of Medicine
William Jarrard Medcial College of Georgia School of Medicine
Ruhul Rao Tulane University School of Medicine
Alexandria Sadasivan Albany Medical College of Union Univeristy
Corinne Smith Lake Erie College of Osteopathic Medicine, Erie
Carlos Villamizer-Roales University of Texas Medical School at Houston
Neurology Fellows Medical School Attended Residency Training
Bradley Klein, MD State University of NY Upstate
Medcial University
New York Presbyterian-
Columbia University Medical
Center Neurology
Pratit Patel, M.B., BS Ssurat Municipal Institute of
Medical Education
Univrsity of Minnesota Medical
Center Neurology
Habibullah Ziayee, MD St. George’s University, School
of Medicine
Jackson Memorial Hospital
Neurology
Muhammad Bilal, M.B., B.S. Quaid-E-Azam Medical
College, Islamia University
University of Louisville
Neurology
Minji Kim, MD Yeungnam University – South
Korea
New York Presbyterian-
Columbia University Medical
Center Neurology
Adam Kney, MD
University of Illinois College of
Medicine
University of Pittsburgh Medical
Center Child Neurology
143
Mahmoud Salhab, MB., B.S.
Jordan University of Science
and Technology, Faculty of
Medicine
University of New Mexico
Neurology
Stephanie Paolini, MD University of South Carolina
School of Medicine
University of Pittsburgh Medical
Center Neurology
Robyn Massa, MD University of Maryland School
of Medicine
University of Pittsburgh Medical
Center Neurology
Jason Massa, MD
Andrew Levin, MD Ohio State University College
of Medicine
University of Pittsburgh Medical
Center Neurology
Megan Mantica, MD State University of NY Upstate
Medical University
University of Pittsburgh Medical
Center Neurology
Cynthia Kenmuir, MD University of Toledo College of
Medicine
University of Pittsburgh Medical
Center Neurology
Gregory Walker, MD University of British Columbia,
Faculty of Medicine
Uniersity of British Columbia
Neurology
Departing House Officers
Residents New Position
Alexandra Czap, MD
Neuro-Oncology Fellowship
Massachusetts General Hospital and Dana-Farber
Cancer Institute/Bridham and Women’s Hospital
Stella Lai, MD
Clinical Neruophysiology Fellowship
University of Chicago
Andrew Levin, MD
Headache Fellowship
Department of Neurology UPMC
Megan Mantica, MD Neuro-Oncology Fellowship
Department of Neurology UPMC
Jennifer Nichols, MD
Movement Fellow
Oregon Health & Science University
Stephanie Paolini, MD
Clinical Neurophysiology Fellow
Department of Neurology UPMC
Fellows New Position Location
Kaustubh Limaye, MD Neurology Faculty
University of Iowa Health Care
Gregory Walker, MD
Neruoendovascular Fellow
Clinical Instructor
Department of Neurology
UPMC
144
Prasanna Tadi, MD
Assistant Professor Department of Neurology Creighton
University CHI Health, Omaha,
Nebraska
Levi Shelton Assistant Professor Department of Pediatrics, Division of
Child Neurology
Neil Munjal Critical Medicine Fellowship
Children’s Hospital of Pittsburgh
UPMC
Jenna Gaesser Assistant Professor Department of Pediatrics, Division of
Child Neurology
Adam Kney Clinical Neurophysiology
Fellowship
Department of Neurology
UPMC
Diana Mnatsakanova, MD NeuroMuscular Fellow University of Iowa Health Care
Katherine Anetakis, MD Assistant Professor in
Neurological Surgery
Center for Clinical Neurophysiology
UPMC
Cosmin Sandulescu, MD Neurology Faculty Attending Geisinger Healthcare System
Fellowship Directors
Alexandra Urban, MD Epilepsy Fellowship Program
Robert Kaniecki, MD Headache Fellowship Program
Ashutosh Jadhav, MD Vascular Neurology Fellowship Program
Brian Jankowitz, MD EndoVascular Fellowship
Timothy Greenamyre, MD Movement Disorders Fellowship Program
Alexandra Urban, MD Clinical Neurophysiology
Jan Drappatz, MD Neuro-Oncology Fellowship
Neurology Mentors
Jun Chen, MD Lili Zhang
Yun Wu
Zhongfeng Weng
David Lacomis, MD David Avila
145
Faculty Teaching and Mentoring Contributions
Junior Faculty Research Mentoring
Jun Chen, MD
Feng Zhang, MD, PhD
Research Assistant Professor
Studies cellular & molecular mechanisms of ischemic neuronal injury
using rodent models of brain ischemia. Supported by AHA SDG award.
Xiaoming Hu, MD
Research Assistant Professor
Studies mechanisms of neuron-glia interactions under conditions of
ischemic injury or Parkinson’s disease.
Ruth Anne Stetler, PhD
Research Assistant Professor
Investigating the molecular mechanism underlying ischemic brain injury
and neuronal cell death.
Kiang Fong Liou, PhD
Research Assistant Professor
Study molecular and cell biology methods to identify key proteins that
participated in the cell death process in response to toxins.
Paula Clemens, MD
Hongshuai Li, MD, PhD
Assistant Professor of Orthopedic Surgery, University of Pittsburgh
Michele Yang, MD
Clinical Instructor, Pediatric Neurology, Denver Children’s Hospital,
Denver, CO
Roxanna Bendixen, PhD
Assistant Professor of Occupational Therapy, University of Pittsburgh
Amber van Laar, MD, PhD
Instructor, Neurology, University of Pittsburgh
Araya Puwanant, MD
Assistant Professor of Neurology, University of Pittsburgh
David Lacomis, MD
Udai Pandy, PhD Dept. of Pediatrics and Neurobiology, CHP: molecular mechanisms of ALS
Post-Doctoral Research Mentoring
Arun Antony, MD
Brian Hanrahan, MD Neurology, Resident University of Pittsburgh School of Medicine
Anto Bagic, MD, PhD
Stephanie Paolini, MD
Neurology Resident EEG Project mentor with Dr. Baldwin
Megan Mantica, MD
Neurology Resident EEG Project mentor with Dr. Baldwin
146
Sergiu Abramovici, MD
PGY5 Epilepsy Fellow ICM Project, Epidemiology Chapter, SPECT project
Palak Shah, MD
PGY6 Epilepsy Fellow SPECT Project
Jenna Robinson
UPitt Neurosci Prog Student EMU Care Project
Sarah Berman, MD, PhD
Victor Van Laar, PhD The role of parkin in neuronal mitochondrial dynamics
April Dukes, PhD Neuroprotection by selenoproteins against toxin-induced cell death
Edward Burton, MD, DPhil
April Dukes, PhD Neuroprotection by selenoproteins against toxin-induced cell death
Victor Van Laar, PhD Mitochondrial dynamics in neurodegeneration
Guodong Cao, PhD
Qinghai Xia Visiting Scholar, Department of Neurology, University of Pittsburgh
Xinzhi Chen, MD, PhD Research Associate, Department of Neurology, University of Pittsburgh
Fenghua Chen Research Associate, Department of Neurology, University of Pittsburgh
Lihong Hang Visiting Scholar, Department of Neurology, University of Pittsburgh
Jun Chen, MD
Guohua Wang Postdoctoral Fellow, University of Pittsburgh
Jinchao Xia Postdoctoral Fellow, University of Pittsburgh
Shangfeng Zhao Postdoctoral Fellow, University of Pittsburgh
Ziangrong Liu Postdoctoral Fellow, University of Pittsburgh
Kathy Gardner, MD
Emin Fedan, MD Postdoctoral Fellow, University of Pittsburgh
Cheran Erlangovan, MD Postdoctoral Fellow, University of Pittsburgh
Monica Vulchi, MD Postdoctoral Fellow, University of Pittsburgh
Navya Dasyam, MD Postdoctoral Fellow, University of Pittsburgh
Steven Graham, MD, PhD
Robert Hickey, MD Pediatrics mentor
147
J. Timothy Greenamyre, MD, PhD
Briana De Miranda, PhD Postdoctoral Fellow
Emily Rocha, PhD Postdoctoral fellow
Chris Bodle, PhD Postdoctoral fellow
Teresa Hastings, PhD
Caitlyn Barrett, PhD Role of mitochondrial GPx4 in neuroprotection
Julie M. Breckenridge, PhD Neuroprotection by selenoproteins against toxin-induced cell death
Xiaoming Hu, MD
Jing Xu, PhD Post-Doctoral Fellow, Visisting Scholar, University of Pittsburgh
Wen Zhu, MD Post-Doctoral Fellow, Research Associate, University of Pittsburgh
Yanling Wang, MD Post-Doctoral Fellow, Associate Professor, Luhe hospital, China
Milos Ikonomovic, MD
Zhiping Mi, PhD
Postdoctoral fellow
Oxidized Phospholipids and Synaptic changes in Mild Cognitive
Impairment
Brista Iordanova, PhD
Postdoctoral Research Fellowship Training in the Neurobiology of
Neurological Disease “Effects of cerebral amyloid angiopathy on blood
flow and oxygen metabolism?
Samay Jain, MD, MSc
Amber Van Laar, MD Movement Disorders Fellowship
Jen Han, MD Movement Disorders Fellowship
Lauren Nathbony, MD Resident Mentor
Cosmin Sandulescu, MD Movement Disorders Fellowship
Robyn Massa, MD Movement Disorders Fellowship
Tudor Jovin, MD
Ridwan Lin, MD
Interventional Neuroradiology Fellowship, Riverside Medical Center,
Columbus, OH
Dean Kostov, MD Interventional Neuroradiology Fellowship
Hilal Kanaan, MD Interventional Neuroradiology Fellowship
Mouhammad Jumaa, MD Interventional Neuroradiology Fellowship
Syed Zaidi, MD Interventional Neuroradiology Fellowship
David Panczykowsky, MD Interventional Neuroradiology Fellowship
148
Grefory Weimer, MD Interventional Neuroradiology Fellowship
Cynthia Kenmuir, MD Interventional Neuroradiology Fellowship
Laurie Knepper, MD
Steve Gangloff Neurology Resident PGY-1
David Lacomis, MD
Deepak Soneji Neurology Resident PGY-1
Bradley Molyneaux, MD, PhD
Hazem Shoirah University of Pittsburgh Stroke Fellow
Jullie Pan, MD, PhD -
Palak Shah, MD Epilepsy Fellowship research program
Vincent Carson, MD “Quantitative EEG, resting connectivity and AED withdrawal,”
Department of Pediatric Neurology
Lori Shutter, MD
Ruchira Jha, MD Junior Neurocritical Care Faculty
Susanne Muehlschlegel, MD Assoc Professor of Neurology UPMC
Jonathan Elmer, MD Asst Prof Dept of Emergency Medicine and Critical Care UPMC
Josh Keegan, MD Neurocritical Care Medicine Fellow
Namir Khandker, MD Neurocritical Care Medicine Fellow
Dandan Sun, MD, PhD
Nabiul Hasan
Postdoctoral fellow Study of C1 transporters in ischemic brain injury
Susan Song
Postdoctoral fellow Study of C1 transporters in ischemic brain injury
Karen Carney
Postdoctoral fellow Study of DHA-mediated neuroprotection after traumatic brain injury
Iqbal Bhuiyan
Postdoctoral Fellow Study of intracellular Ca2+ rise in microglial migration
Gulnaz Begum
Postdoctoral Fellow Study of chloride transporter in GBM tumor cells
Alexandra Urban, MD
Ahmed Yassin, MD
PGY6 Epilepsy Fellow QI Project: The effect of automatic SPECT njectors (ASI) on the safety and
yield of obtained SPECT studies
149
Brian Hanrahan, MD
Neurology Chief Resident QI Project: Improving the process and efficiency of stat EEG
Anne Van Cott, MD
Kara Wyant, MD University of Pittsburgh Neurology Resident
Alexis Steinberg, MD University of Pittsburgh Neurology Resident
Christina Catherine, MD, PhD University of Pittsburgh Neurology Resident
Janet Waters, MD
Stella Lai University of Pittsburgh Neurology Resident
Kejie Yin, MD, PhD
Xuejing Zhang Postdoctoral Fellow, Neurology Department UPMC
Ping Sun Postdoctoral Fellow, Neurology Department UPMC
Xinxin Yang Postdoctoral Fellow, Neurology Department UPMC
Feng Zhang, MD, PhD
Zhongfang Weng Postdoctoral Student, University of Pittsburgh
Lili Zhang Postdoctoral Student, University of Pittsburgh
Yang Sun Postdoctoral Student, University of Pittsburgh
Tuo Yang Postdoctoral Student, University of Pittsburgh
Graduate Student Mentoring and Advising
Timothy Greenamyre, MD, PhD
Meghan Bucher, PhD Candidate, CNUP, University of Pittsburgh (JTG, Chair)
Xiaoming Hu, MD
Wei Cai, MD, PhD Sun Yat-Sen Universit exchange student, University of Pittsburgh
Yuguo Xia, MD Research Associate, University of Pittsburgh
Jianyi Wang, MD Xiangya School of Medicine exchange student, University of Pittsburg
Huan Lie, MD Xiangya School of Medicine exchange student, University of Pittsburg
Xuejiao Dai, MD Xiangya School of Medicine exchange student, University of Pittsburg
150
Oscar Lopez, MD
Alexis Steinber, MD
Project: Sensitivity, specificity and reliability of three pathological criteria
for Alzheimer’s disease
Neelesh Nadkarni K-23 K- Awards mentor
Marcelo Rocha, MD, PhD
Shashvat Desai, MD
Research Post-doctoal Fellow, Research Project: Clinical Characterizaton of
fast and slow progressors of LVO using observational retrospective studies
Lori Shutter, MD
Yumna Saeed, MD Neurocritical Care Interest
Beth Snitz, PhD
Sarah Goldberg Clinical Supervisor – Psychology
Ryan Malave Master’s student – Epidemiology, Thesis project co-advisor
Dandan Sun, MD, PhD
Yang Chung
PhD candidate – Thesis committee member of CNUP, University of
Pittsburgh
Xiudong Guan, MD PhD Student – Tiantan Medical Hospital, China
Hanshu Zhao, Graduate
Student Study of roles of Na+/H+ exchanger in microglial activation after ischemia
Ann Van Cott, MD, FAAN
Megan Miller Univerity of Pittsburgh PhD candidate
Kejie Yin, MD, PhD
Xuelian Tang University of Pittsburgh, Department of Neurology, UPMC
Feng Zhang, MD, PhD
Meijuan Zhang Pre-doctoral students: University of Pittsburgh
Leilei Mao Pre-doctoral students: University of Pittsburgh
Yang Sun Pre-doctoral students: University of Pittsburgh
Jessica Zhang Pre-doctoral students: University of Pittsburgh
Peiying Li Pre-doctoral students: University of Pittsburgh
Haiyue Zhang Pre-doctoral students: University of Pittsburgh
Undergraduate Mentoring and Advising
Anto Bagic, MD, MSc, PhD
Julia Zheng
University of Pittsburgh Neuroscience Program Student EEG-MEG Project
2013-Present
151
Sarah Berman, MD, PhD
Swati Rajprohat June 2013 - Present
Teresa Hastings, PhD
Meghan Bucher Research project: Role of selenoproteins in models of Parkinson’s disease
Shruthi Shankar
Research project: Role and interacting partners of neuronal Na+K+ATPase,
alpha 3
Milos Ikonomovic, MD
Andrew Morrison 2013 - 2016 – University of Pittsburgh, Thesis Research and Writing
Ye Weon Ryu 2013 – Present – University of Pittsburgh, Thesis Writing
Alisha Ambe 2016 - Present – University of Pittsburgh, Independent Research
Grazia Candiotti 2014 - 2016 – University of Pittsburgh, Thesis Research and Writing
Beth Snitz, PhD
Jessica Kerstetter Spring 2016 – Research Advisor – First Experience in Research
Taylor Urban Spring 2016 – Research Advisor – First Experience in Research
Dandan Sun, MD, PhD
Abhishek Mishra Study DHA-mediated neuroprotection after traumatic brain injury
Rachana Nayak Study DHA-mediated neuroprotection after traumatic brain injury
Alexandra Urban, MD
Jenna Robinson Undergraduate Neuroscience – Project QI: Subtle MRI lesions in patients with
intractable epilepsy and normal MRIs
Medical Student Mentoring
Sarah Berman, MD, PhD
Megan Bucher Comprehensive Exam Committee, Center for Neuroscience at UPMC
Anthony Otero
Comprehensive Exam and Doctoral Dissertation Committee,
Interdisciplinary Biomedical Graduate Program
Darius Becker Krail Comprehensive Exam Committee, Center for Neuroscience at UPMC
Briana De Miranda, PhD
Advisory Committee Member, NINDS Postdoctoral fellowship: Training in
the Neurobiology of Disease - UPMS
152
Edward Burton, MD, DPhil
Jacob Kantorotwitz Pitt MD student scholarly project mentor 2016 - present
Neil Sharma Pitt MD student scholarly project mentor 2016 - present
Phil Bartel Pitt MD student scholarly project mentor 2016 - present
Wenting Xie Tsinghua Scholar mentor 2015- present
Enhua Shao Tsinghua scholar mentorship 2015- present
Jan Drappatz, MD
Daniel Lesky Medical Student precepting - Neoplasia
Myung Sun Choi Medical Student precepting - Neoplasia
Allana White Medical Student precepting - Neoplasia
Daniel Suter Medical Student precepting - Neoplasia
Bhavana Chapman Medical Student precepting - Neoplasia
Samay Jain, MD, MSc
Julie Garringer MS II
Seth Hepner MS III/IV
David Lacomic, MD
Deepak Soneji Mentor – for PGY-4 resident
Bill Su Mentor – for PGY-1 resident
Oscar Lopez, MD
Sarah Yousef Medical Student
Marcelo Rocha, MD, PhD
Devin Burke, MD
Neurology Resident – Project: Predicting hemorrhagic conversion of
ischemic strokes after initiation of anticoagulation of secondary stroke
prevention
Lori Shuter, MD
Kiruba Dharaneeswaran, MD Neurology Resident (Neurocritical Care interest) UPMC
Alexis Steinberg, MD Neurology Resident (Neurocritical Care interest) UPMC
Christian Ricks, MD Neurology Resident (Neurocritical Care interest) UPMC
153
Beth Snitz, PhD
Yujing Zhao Medical Student – Scholarly Project mentor
Valerie Suski, MD
Michelle Daile Medical Student – University of Pittsburgh School of Medicine 2016-2017
Zongqi Xia, MD, PhD
Michael Isofort, MD Resident Research Project: health care utilization pattern in MS patients
receiving disease-modifying treatments.
Shreya Nayak, MD Supervised completing a review article: emerging biosensor monitor in
chronic neuroinflammaton and neurodegeneration
Faculty Participation in Graduate Level Teaching, Mentorships, and Service
Jun Chen, MD Lecture
Apoptosis-Cellular and Molecular
Neurobiology MSNBIO
J. Timothy Greenamyre, PhD Lecture Bioenergetics and Excitotoxicity
Lecture Mitochondrial Disorders
Lecture Parkinson’s disease
Teresa Hastings, PhD 7 Lectures Cellular and Molecular Neurobiology
Lecture Neuropharmacology
Course Director
John Doyle, MD Co-Director of Neuroscience Course PMS1
Co-Director of Neurology CME Course, Neurology in the Medicial Office
Jeffrey Esper, DO, MS Clinical Course Director – Neurosensory System at LECOM
Teresa Hastings, PhD Director, Honors College Health Sciences Undergraduate Summer Research
Fellowship Program
Cellular and Molecular Neurobiology
Milos Ikonomovic, MD MSNBIO – Topics in Neurological Disorders
Laurie Knepper, MD Clinical Neuroscience Clerkship (Co-Director)
The Neurological Examination
Janet Waters, MD Co-Director of CME course: Obstetrical Neurology Conference
Claire Yanta, MD Advanced Physical Examination, Neurology Section
Assistant Clerkship Director
154
Additional Graduate Student Mentoring and Advising
Sarah Berman, MD, PhD
PSTP Career Advisor 2013–
Present Kassandra O’Brien
PSTP Career Advisor 2014–
Present Wai Lok (Cyrus) Tsang
152
PSTP Career Advisor 2015–
Present Andrew Lamade
MSTP Career Advisor 2017-
present Jenna Gale
MSTP Career Advisor 2017-
present Rahilla Tarfa
J. Timothy Greenamyre, MD, PhD MSTP Career Advisor Gil Hoftman
MSTP Career Advisor Michelle Dail
MSTP Career Advisor Eric Strobl
Teresa Hastings, PhD CNUP Graduate Advisor
Committee Zhenyu Liu
CNUP Graduate Advisor
Committee Louisa Ho
CNUP Graduate Advisor
Committee Leslie Colgan
CNUP Graduate Advisor
Committee Victor Van Laar
CNUP Graduate Advisor
Committee Nicole Larsen
Beth Snitz, PhD PhD Committee Meghan Mattos
PhD Committee Samantha Rosenthal
Committee Memberships
Sarah Berman, MD, PhD Member, PSTP Admissions Committee
Member, PSTP Steering Committee
Member, MSTP Admissions Committee
Member. MSTP Admissions/Recruiting
Committee
Member, MSTP Advisory Committee
Edward Burton, MD, DPhil Member, FAST Advisory Committee
155
Teresa Hastings, PhD Member, MSTP/CNUP Admissions Committee
Member, MSTP Steering Committee
Dandan Sun, PhD Member, CNUP Evaluation Committee
Member, CNUP Recruitment
Thesis and Dissertation Committee Service
Sarah Berman, MD, PhD Member, Doctoral
Dissertation Committee Anthony Otero
153
Teresa Hastings, PhD Chair –CNUP Dissertation
Committee Mahlon Collins
Member – CNUP Dissertation
Committee Hyunjung Oh
Member –CNUP Dissertation
Committee Eser Yilmaz
Faculty Participation in Medical School Teaching, Mentorships, and Service
Teaching
Arun Antony, MD
Clinical Conference 1: Localizing sensory and motor
Dysfunction MS1: Neuroscience
5 Lectures: Seizures and Epilepsy MS1: Neuroscience
Anto Bagic, MD, PhD
Lecture: Intro to pathophysiology of epileptic seizures MS1: Neuroscience
Clinical Pharmacology MS4: Clinical Pharmacology
Lecture: Brief Overview of seizures and epilepsy MS1: Neuroscience
Lecture: Intro to Treatments of Seizures and Epilepsy MS1: Neuroscience
Sarah Berman, MD
Lecture: Tremor and Dystonia MS1: Neuroscience
Edward Burton, MD, DPhil
Myoclonus, tics, and other movement disorders (NO
PODCAST) MS1: Neuroscience
Ataxia (NO PODCAST) MS1: Neuroscience
156
Neil Busis, MD
Clinical Conference 3: Syndromes Involving Brainstem and
Cranial Nerves MS1: Neuroscience
Clinical Conference 2: Motor Systems MS1: Neuroscience
Clinical Conference 4: Localizing sensory and motor
dysfunction MS1: Neuroscience
Guodong Cao
Lecture: Neuropharmacology MS4: ILS Clinical Pharmacology
Paula Clemens, MD
2 -PBL Introduction: “Trouble Walking” MS1: Cellular & Path Basis of Disease
John Doyle, MD
Introduction to the Course MS1: Neuroscience
Lab1: CNS Anatomy: Forebrain MS1: Neuroscience
Neuroanatomy Workshop 1: Coronal and horizontal brain
sections MS1: Neuroscience
Lecture: Localization and Clinical Neurology MS1: Neuroscience
Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience
Clinical Conference 2: Syndromes Involving Brainstems and
Cranial Nerves MS1: Neuroscience
Lectures: Radiology Review MS1: Neuroscience
Lecture: Ataxia MS1: Neuroscience
Lecture: Clinical Phenomenology of Movement MS1: Neuroscience
Clinical Conference 3: Motor Systems MS1: Neuroscience
Case: Integrative review case 1: Autonomic Nervous
System Disorders MS1: Neuroscience
Case: Integrative review case 2: Drugs and Nerve Cell
Function MS1: Neuroscience
Lecture: Attentional Systems & Disorders of Consciousness
(Coma) MS1: Neuroscience
Lecture: Language and Communication MS1: Neuroscience
Jan Drappatz, MD
Lectures: Neuro-Oncologic Emergencies MS4: ILS Neoplasia & Neoplastic Diseases
Erica Grazioli, DO
Lecture: Multiple Sclerosis MS1: Neuroscience
J. Timothy Greenamyre, MD, PhD
Lecture: Parkinson’s Disease, Neurobiology of Disease MS1: Neuroscience
Lecture: Mitrochondrial Disorders, Basic Mechanisms of
Neurological Disease MS1: Neuroscience
Lecture: Bioenergetics and Excitotoxicity, Basic
Mechanism of Neurological Disease MS1: Neuroscience
157
Theresa Hastings, PhD
Lecture: Parkinson’s Disease “Neuropharmacology” MSNBIO 2614 / MSMPL 3375
Rock Heyman, MD
Lectures: Multiple Sclerosis MS1: Neuroscience
Lecture: Problem Based Learning MS1: Neuroscience
Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience
Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience
Clinical Conference 3: Syndromes involving brainstem and
cranial nerves MS1: Neuroscience
Clinical conference 4: Localizing sensory and motor
dysfuntion MS1: Neuroscience
Lectures: Physical Therapy Master: Neuroscience
Lectures: Occupational Therapy Masters: Neuroscience
Houman Homayoun, MD
Lecture: Presentation – NO PODCAST MS1: Neuroscience
3 - Lecture: Movement Disorders MS1: Neuroscience
Lecture: Parkinsonian States MS1: Neuroscience
Ashu Jadhav, MD, PhD
6 Lectures: Stroke MS1: Neuroscience
Tudor Jovin, MD
Lecture: Interventional Neuroradiology MS1: Neuroscience
Robert Kaniecki, MD
6 -Lectures: Headache Assessment and Management MS3: Neurology Clerkship
Clinical Confernce 2: Motor Systems Degeneration MS1: Neuroscience
Lecture: Pharmacology of Pain Management MS4: Clinical Pharmacology
Simin Khavandgar, MD
Clinical Conference 3: Sydromes involving brainstem and
cranial nerves Clinical Conference 3
Clinical Conference 1: Localization of Dysfuntion
Clinical conference 1
Laurie Knepper, MD
12 – Small Groups: Neurological Exam MS1: Intro to Physical Exam
4-ICS Course MS1: Neuroscience
12-Small Groups: NBME Neuro Shelf Review Clerkship MS3: Neurology Clerkship
Clinical Conference l: Localization of Dysfunction MS1: Neuroscience
Clinical Conference 1: Localizing sensory and memory
dysfuntion MS1: Neuroscience
Small Groups: The Neurological Exam-Advance Physical Exam MS3: Neuroscience
158
David Lacomis, MD
Lecture: Critical Illness Neruomuscular Disease MS1: Neuroscience
Lecture: Motor Neuron Disease MS4: Elective Phys Med & Rehab
Lecture: Peripheral Nerve & Anterior Horn Disorders MS1: Neuroscience
Erek Lam, MD
Lecture: Sleep Wake Disorders MS1: Neuroscience
Lecture: Neurobiology of Circadian Rhythms MS1: Neuroscience
Frank Lieberman, MD
Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience
Clinical Conference 4: Localizing sensory and motor
dysfunction MS1: Neuroscience
Oscar Lopez, MD
Small Group: Workshop WS5- Case Studies in Injury and
Repair MS1: Cellular & Path Basis of Disease
Small Group: Workshop WS7 – Case Studies in Neoplasia MS1: Cellular & Path Basis of Disease
Small Group: Workshop WS6 – Virtual Slides: Colon
Adenocarcinoma and Melanoma MS1: Cellular & Path Basis of Disease
Angela Lu, MD
Clinical Conference 1: Localization of Dysfunction MS1: Neuroscience
12 Lectures: Peripheral Neuropathy MS3: Clinical Neuroscience
Bradley Molyneaux, MD
Lecture: Science of Resuscitation MS4: EMED Course
Small Group: Syndromes Involving the Brainstem and
Cranial Nerves, Clinical Conference 2 MS1: Neuroscience
Ajitesh Ojha, MD
Clinical Conference 2: Motor Systems Degeneration MS1: Neuroscience
Clinical Conference 3: Syndromes involving brainstem and
cranial nerves MS1: Neuroscience
Clinical Conference 4: Localizing sensory and motor
dysfunction MS1: Neuroscience
Small Group: APE MS1: Neuroscience
Araya Puwanant, MD
2- Small Group: PBL Introduction: “Trouble Walking” MS1: Cellular & Path Basis of Disease
Lecture: Skeletal Muscle I MS1: Cellular & Path Basis of Disease
Lecture: Skeletal Muscle II MS1: Cellular & Path Basis of Disease
159
Vivek Reddy, MD
Clinical Conference: Traumatic Brain Injury MS1: Neuroscience
Lori Shutter, MD, FCCM, FNCS
Clinical Conference 2: Syndromes Involving the
Brainstem and Cranial Nerves MS1: Neuroscience
157
Clinical Conference 4: Localizing Sensory and Motor
Dysfunction MS1: Neuroscience
Lecture: Surgery Internship Preparation Course
“Pronouncing Patient Death” MS4: Neuroscience
2 - Lectures: Introduction to Medical Decision Making MS1: Neuroscience
Beth Snitz, PhD
Lecture: Multimodal methodologies to assess CNS
disorders in epiedemiologic studies MS1: Neuroscience
Lecture: Dementia/Major Neurocognitive Disorders MS1: Neuroscience
Lecture: Principals of Neuroepidemiology MS1: Neuroscience
Josef Stakic, MD
Clinical Conference 1: Localization of dysfunction MS1: Neuroscience
Clinical Conference 3: Syndromes involving brainstem and
cranial nerves MS1: Neuroscience
Clinical Conference 4: Localizing sensory and motor
dysfunction MS1: Neuroscience
Lecture: Dementia and Delirium MS1: Neuroscience
6 - Lecture: Headache MS3: Neurology Clerkship
Valerie Suski, DO
Clinical Conference 3: Syndromes involving brainstem and
cranial nerves MS1: Neuroscience
Small Group: APE Session, Neuro examination MS2: Advanced Physical Exam 2
Alexandra Urban, MD
Lecture: Management of Epilepsy-Epilepsy vignettes,
Clinical Pharmacology MS4: ILS Clinical Pharmacology
Clinical Conference 4: Localizing Sensory and Motor
Dysfunction MS1: Neuroscience
Small Group: APE Neurology Advance Physical Exam MS12: Advanced Physical Exam 1
3- Lectures: Diagnosis and Management of Seizures MS3: Clinical Neuroscience Clerkship
Anne Van Cott, MD
PBL Sessions: Case 7, 8 and 9 MS2- Integrated Case Studies
160
Amber Van Laar
Lecture: Tremor and Dystonia MS1: Neuroscience
3 Lectures: Movement Disorders Overview MS1: Neuroscience
Janet Waters, MD
Lecture: Neurology in Pregnancy MS1: Clinical Neuroscience
Lawrence Wechsler, MD
Clinical Conference 4: Localization Sensory and Motor
Dysfunction MS1: Neuroscience
Claire Yanta, MD
Lecture: Neurocognitive Foundations of Executive
Function/Frontotemporal Dementia MS1: Neuroscience
Lecture: Neurological Examination MS1: Advance Physical Exam 1
3 - Small Groups: The Neurological Exam-Advance
Physical Exam MS1: Advance Physical Exam 1
Islam Zaydan, MD
Lecture: Alzheimer’s and Lewy body dementia MS1: Neuroscience
5 - Lectures: Multiple Sclerosis & CNS demyelinating
diseases MS1: Neuroscience
Lecture: Dementia MS1: Neuroscience
Sasa Zivkovic, MD
Clinical Conference 2: Syndromes involving Brainstem and
Crainial Nerves and Motor Degeneration MS1: Neuroscience
Clinical Neuroscience Clerkship MS3: Clerkship
Lecture: Neurobiology of Disease MSN2112 / NROSCI2112
Medical Student Mentoring
Sarah Berman, MD Mentored Scholarly
Project Roy Nikita
Paula Clemens, MD Mentored Scholarly
Project Corey Toocheck
Samay Jain, MD Mentored Scholarly
Project Christian Agudelo
161
162
Department of Neurology Grand Rounds 2016-2017
Sept 7, 2016 VISITING
Allison Brasher, MD Title: “Disease of ATP1A3: Learning from our Patients”
1105AB 4-6PM
Sept 14, 2016 Residents CPC Series James Lee, MD Title: “A Diagnosis Frequently Made at Autopsy” Mentor: Jan Drappatz, MD
1105AB 4-6PM
Sept 21, 2016 In-House
Sasa Zivkovic, MD Title: “Guillain Barre Syndrome 1916-2016: First Hundred Years”
1105AB 4-6PM
Sept 28, 2016 In-House
Marcelo Rocha, MD Title: “Pathophysiology of Acute Intracranial Large Vessel Occlusion: Emerging Trends”
1105AB 4-6PM
SECOND QUARTER – OCT-DEC 2016
Oct 5, 2016 Residents CPC Series Eric Jackowiak, MD Title: "Parkinson's, Psychosis, and Pimavanserin" Mentor: Dr. Van Laar
1105AB 4-6PM
Oct 12, 2016 No Grand Rounds – Holiday Break Yom Kippur
Oct 19, 2016 UPMC S701 Scaife Hall
200 Lothrop Street Pittsburgh, PA 15213
Office 412-624-9415
Direct line 412-624-0764
FAX 412-624-5610 [email protected]
Clayton A. Wiley, MD/PhD
Professor of Pathology
Director of Neuropathology
PERF Endowed Chair UPMC Presbyterian Hospital Division of Neuropathology Title: Human Zika and WNV infections: What is the difference? Encephalitis or Encephalopathy?
1105AB 4-6PM
Oct 26, 2016 Residents CPC Series Natalia Gonzales, MD Title: “A Commonly Misdiagnosed Cause of Polyneuropathy: TTR Familial Amyloidosis” Mentor: Sasa Zivkovic, MD
1105AB 4-6PM
Nov 2, 2016 VISITING Dr. Bagic requested
Lawrence Hirsch, MD Yale University School of Medicine Title: “Critical Care EEG Monitoring: Past, Present and Future”
1105AB 4-6PM
Nov 9, 2016
Residents CPC Series Jennifer Nichols, MD Title: "Movement Disorder Emergencies"
Mentor: Houman Homayoun, MD
1105AB 4-6PM
163
Nov 16, 2016 JOINT - Neurosurg
Joint GR – Neurosurgery/Neurology David O. Okonkwo, MD, PhD Prof. & Executive Vice Chair, Clinical Operations Clinical Director, Brain Trauma Research Center Dept. of Neurologic Surgery Title: “Biomarkers and Neuroimaging of Chronic Traumatic Encephalopathy” Julia Kofler, MD Assistant Professor of Pathology Department of Pathology Title: “Neuropathologic Features of CTE”
1105AB 4-6PM
Nov 23, 2016 No Grand Rounds – Holiday Break
Nov 30, 2016 UPMC
Gwendolyn A. Sowa, MD, PhD Co-Director, Ferguson Laboratory for Orthopaedic Research Chair, Department of Physical Medicine & Rehabilitation [email protected] 412-648-6848 Title: “Updates in Low Back Pain: Challenges and Opportunities”
1105AB 4-6PM
Dec 7, 2016 In-House
Josif Stakic, MD Title: “Case Presentation of Progressive Neurologic Decline: Ataxia, Hearing Loss, Cognitive Decline” Patient will be present for the interview and examination
1105AB 4-6PM
Dec 14, 2016 Residents CPC Series Brian Hanrahan, MD Title: “First Time Seizure, When To Start AEDs and Mandatory Reporting” Mentor: Gena Ghearing, MD
1105AB 4-6PM
Dec 21, 2016 Recruit
Benjamin Tolchin, MD, MS Brigham and Women’s Hospital [email protected] Title: “Treatment Adherence and Outcomes in Psychogenic Nonepileptic Seizures"
1105AB 4-6PM Quarter sent to CME
Dec 28, 2016 No Grand Rounds – Holiday Break
THIRD QUARTER JAN-MAR 2017
Jan 4, 2017
Residents CPC Series Megan Mantica, MD Title: "Paraneoplastic Paradigm" Mentor: Dr. Drappatz (out of country) Dr. Lieberman involved at GR
1105AB 4-6PM
Jan 11, 2017 UPMC Paula Nave [email protected] Dawn Allan [email protected]
Steven D. Shapiro, MD Executive Vice President, UPMC Chief Medical and Scientific Officer President, Health Services Division Distinguished Professor of Medicine Title: “Moore’s Law and Medicine: Embrace the Change”
1105AB 4-6PM
164
Jan 18, 2017 Residents CPC Series Stephanie Paolini, MD Title: “Marijuana in Neurology: What is the Evidence” Mentor: Robert Kaniecki
1105AB 4-6PM
Jan 25, 2017 Joint GR – Neurology Rock Heyman, MD (but due to a family emergency Dr. Zaydan gave his talk) Islam Zaydan, MD Title: Evaluation and Biopsy of CNS Inflammatory Lesions L. Dade Lunsford, M.D., F.A.C.S. Lars Leksell Professor of Neurological Surgery Distinguished Professor of Neurological Surgery The University of Pittsburgh Director, Center for Image Guided Neurosurgery Director, Neurosurgery Residency Program Chair, Technology and Innovative Practice Committee
Title: Brain Biopsy: When the Neurologist Calls…
1105AB 4-6PM
Feb 1, 2017 In-House
Robert G. Kaniecki, MD Director, the Headache Center Chief, Headache Division Director, Headache Fellowship Program Assistant Professor of Neurology University of Pittsburgh School of Medicine Title: “Cloudy with a Chance of Migraine”
1105AB 4-6PM
Feb 8, 2017 Residents CPC Series Jody Manners, MD Title: “A Lesson in Lesions: Transverse Myelitis and A Mimic”
1105AB 4-6PM
Feb 15, 2017 In-House
Ruchira Jha, MD Assistant Professor, CCM & Neurology Title: “Cerebral Edema in TBI: A Translational Assessment of the Role of Sulfonylurea Receptor 1”
1105AB 4-6PM
Feb 22, 2017 Residents CPC Series Alexis Steinberg, MD Title: "Can Seizing the Day Help Predict Tomorrow? The Role of EEG After Cardiac Arrest."
1105AB 4-6PM
Mar 1, 2017 In-House (Neurosurg)
Bradly Gross, MD Title: “Great Masqueraders: Cerebral Dural Arteriovenous Fistulas”
1105AB 4-6PM
Mar 8, 2017 In-House
Zongqi Xia, MD, PhD Title: “Multiple Sclerosis: Towards Precision Medicine in the Omics Era”
1105AB 4-6PM
Mar 15, 2017 Residents CPC Series Andrew Levin, MD Title: “Rekindling from Burnout in Neurology”
1105AB 4-6PM
165 Mar 22, 2017 In-House
Islam Zaydan, MD Title: “OCT in Neurology”
1105AB 4-6PM
Mar 29, 2017 Joint
Joint GR – Neurosurgery Neurology: Amber Van Laar, MD Neurology Lead Investigator, AAV2-AADC Gene Therapy for Parkinson’s Disease Department of Neurology, UPMC Neurosurgery: Mark Richardson, MD, PhD Principle Investigator, AAV2-AADC Gene Therapy for Parkinson’s Disease Department of Neurological Surgery, UPMC Title: “Phase 1 Results of Enzyme-Replacement Gene Therapy for Parkinson’s Disease”
1105AB 4-6PM
FOURTH QUARTER – APR-SEPT
Apr 5, 2017 Residents CPC Series Stella Lai, MD
Title: "Cognition in Children Born to
Women with Epilepsy"!
1105AB 4-6PM
Apr 12, 2017 VAPHS
Anne Van Cott, MD, Associate, Prof., Univ. of Pitt/VAPHS Hoby Hetherington, Visiting Prof. PhD, Dept of Radiology, Director MRRC Title: “Traumatic Brain Injury, Post-Traumatic Stress Disorder and 7TMRSI in Veterans”
1105AB 4-6PM
Apr 19, 2017 Residents CPC Series Alexandra Czap, MD Title: “Seeking Immunity: Novel Approaches to GBM”
1105AB 4-6PM
Apr 26, 2017 No Grand Rounds - AAN MEETING
May 3, 2017 Visiting
Paola Sandroni, MD, PhD Mayo Clinic/Rochester Title: “Postural Tachycardia Syndrome (POTS): Demystifying a Common Autonomic Disorder” 5:30pm Patient/Caregiver program: Title: "POTS: Unwrapping the Whole Package."
1105AB 4-6PM
May 10, 2017 Residents CPC Series Kiruba Dharaneeswaran, MD Title: “Flavi-ors of Acute Flaccid Paralysis in North America”
1105AB 4-6PM
May 17, 2017 CANCELLED 1105AB 4-6PM
May 24, 2017 In-House
Janet Waters, MD, MBA Title: “The Zika Virus and Its Impact on Pregnancy”
1105AB 4-6PM
166
May 31, 2017 Residents CPC Series
Deepak Soneji, MD, PhD Title: "Neurostimulants in Stroke Rehabilitation" Mentor: Dr. Jadhav has been the one helping me the most.
1105AB 4-6PM
SUMMER BREAK
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Departmental Bibliography 2015-2017
Cognitive and Behavioral Neurology Division
Oscar Lopez, MD, Professor and Division Chief
Espinosa A, Alegret M, Valero S, Vinyes-Junqué G, Hernández I, Mauleón A, Rosende-Roca M, Oscar
L. Lopez, MD Page 28 06/20/2015
Wang L, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L,
Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT,
Munger RG, Corcoran CD, Rogaeva E, Lin C, Dombroski BA, Cantwell LB, Partch A, Valladares O,
Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens
TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD; for the National
Institute on Aging–Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study; Alzheimer’s Disease
Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Barnes
LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve
BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC,
Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R,
Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M,
Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-
Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin L, Jun G,
Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah
JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson
DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee
AC, Mesulam MM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM,
Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M,
Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin
AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE,
Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ,
Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S,
Woltjer RL, Wright CB, Younkin SG, Yu C, Yu L. Rarity of the Alzheimer Disease-Protective APP A673T
Variant in the United States. JAMA Neurology 2015 Feb;72 (2):209-216 [PMCID: PMC4324097].
International Genomics of Alzheimer's Disease Consortium (IGAP): Jones L, Lambert JC, Wang LS, Choi
SH, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards R, Bellenguez C, Ibrahim-Verbaas CA,
Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis AL, Beecham GW, Grenier-Boley B, Russo G,
Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN,
Kamatani Y, Lin CF, Schmidt H, Kunkle BW, Dunstan ML, Ruiz A, Bihoreau MT, Reitz C, Pasquier F,
Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Becker JT, Gudnason V,
Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston
JA, Evans D, Lovestone S, Letteneur L, Kornhuber J, Tárraga L, Rubinsztein DC, Eiriksdottir G, Sleegers
K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Emilsson V, Brown K, Kamboh MI, Keller L, Barberger-
Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Kehoe P, Rogaeva
E, Gallacher J, St George-Hyslop P, Clarimon J, Lleò A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù
P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox N, Hardy J, Naranjo MCD, Razquin C, Bosco
P, Clarke R, Brayne C, Galimberti D, Mancuso M, MRC CFAS, Moebus S, Mecocci P, del Zompo M,
Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Benedetta Nacmias B, Gilbert JR, Mayhaus
M, Jessen F, Dichgans M, Lannfelt L, Hakonarson H, Pichler S,
169
Carrasquillo MM, Ingelsson M, Beekly D, Alavarez V, Zou F, Valladares O, Younkin SG, Coto E,
Hamilton-Nelson KL, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC,
Cantwell LB, Soininen H, Blacker D, Mead S, Mosley Jr. TH, Bennett DA, Harris TB, Fratiglioni L,
Chaudhry M, Wang X, Hasnain S, Demirci FY, Ganguli M, Lopez OL, Kamboh MI. Genetic Variation in
Imprinted Genes is Associated with Risk of Late-Onset Alzheimer’s disease. Journal of Alzheimer’s
Disease 2015 Jan 1; 44(3):989-994 [PMCID: PMC4324355].
Wang X, Lopez OL, Sweet RA, Becker JT, DeKosky ST, Barmada MM, Demirci Y, Kamboh MI. Genetic
determinants of survival in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease. 2015; 42
(2): 649-655. [PMCID: PMC4245313].
Boyle CP, Raji CA, Erickson KI, Lopez OL, Becker JT, Gach HM, Longstreth WT Jr, Teverovskiy L,
Kuller LH, Carmichael OT, Thompson PM. Physical activity, body mass index, and brain atrophy in
Alzheimer's disease. Neurobiology of Aging. 2015 Jan; 36 Suppl 1:S194-202 [PMCID: PMC4303036].
Riverol M, Becker JT, Lopez OL, Raji C, Thompson PM, Carmichael O, Gach HM, Longstreth W, Fried
L, Tracy RP, Kuller LH. Cystatin C predicts white matter lesions, gray matter volume and cognitive
function among cognitively normal elderly. Journal of Alzheimer’s Disease, 2015; 44(1):319-328 [PMCID:
PMC4297227].
Hohman T, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro
ML, Rajbhandary R, Vardarajan BD, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR,
Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin
CT, Green RC, Barnes LL, Cantwell LB, Fallin D, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta
KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM,
Lang R,. Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD,
Mayeux R,Haines JL, Thornton-Wells TA, for the Alzheimer Disease Genetics Consortium.Global and
Local Ancestry in African Americans: Implications for Alzheimer’s Disease Risk. Alzheimer’s &
Dementia, 2015 Jun 16. pii: S1552-5260(15)00190-9. doi: 10.1016/j.jalz.2015.02.012.
Hughes TM, Craft S, Lopez OL. The potential role of arterial stiffness in the pathogenesis of Alzheimer’s
disease. Neurodegenerative Diseases Management 2015 Apr;5 (2):121-135 [PMCID: PMC4423756].
Nadkarni N, Perera S, Hanlon JT, Lopez OL, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky
S, Yaffe K, Rosano C. Statins and brain integrity in older adults: Secondary analysis of the Health ABC
Study. Alzheimers & Dementia 2015 (Jan 12) [Epub ahead of print].
Chauhan G, Adams HH, Bis JC, Weinstein G, Yu L, Töglhofer AM, Smith AV, van der Lee S, Gottesman
RF, Thomson R, Wang J, Yang Q, Niessen WJ, Lopez OL, Becker JT, Phan TG, Beare RJ, Arfanakis K,
Fleischman D, Vernooij MW, Mazoyer B, Schmidt H, Srikanth V, Knopman DS, Jack, Jr. CR, Amouyel
P, Hofman A, DeCarli C, Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT, Mosley TH,
Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Association of Alzheimer disease GWAS loci
with MRI-markers of brain aging. Neurobiology of Aging 2015 Apr; 36(4):1765.e7-1765.e16 [PMCID:
PMC4391343].
Snitz BE, Cohen AD, Lopez OL, Nebes R, McDade E, Aizenstein HJ, Weissfeld LA, Price JA, Mathis
CA, Klunk WE. Neuroticism, subjective cognitive complaints and beta-amyloid deposition in older adults
without dementia. American Journal of Geriatric Psychiatry, 2015 Sep 23(9):985-993 [PMCID:
PMC4532656]
170
Jun G, Ibrahim-Verbaas CA, Vronskaya M, PhD, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS,
Bis JC, Bellenguez C, Lunetta KL, Harold D, Destefano AL, Grenier-Boley B, Beecham GW, Smith AV,
Escott-Price V, Chouraki V, Hamilton-Nelson KL, Gerrish A, Ikram M, Fievet N, Martin ER, Sims R,
Schmidt H, Kamatani Y, Valladares O, Ruiz A, Zelenika D, Foroud TM, Choi SH, Boland A, Kukull WA,
van der Lee SV, Pasquier F, Beekly D, Fitzpatrick AL, Hanon O, Barber R, Gudnason V, Campion D,
Bennett DA, Amin N, Berr C, Buxbaum JD, Lopez OL, Deramecourt V, Cantwell LB, Tárraga L, Dufouil
C, Crane PK, Eriksdottir G, Hannequin D, Evans D, Mosley TH, Letenneur L, Goate AM, De Jager P,
Jakobsdottir J, Dartigues JF, Kamboh MI, de Bruijn RFAG, Tzourio C, Larson EB, Rotter J, Montine TJ,
Nalls MA, Reiman E, Jonsson P, St. George-Hyslop P,Boada M, Wendland JR, Schmidt R, Winslow AR,
Younkin SG, Hofman A, Wilhelmsen KC, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C,
Launer LJ, Mayeux R, Lathrop M, Holmans P, Seshadri S, Pericak-Vance M, Amouyel P, Williams J, van
Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer’s disease locus located near the gene encoding
tau protein. Molecular Psychiatry. 2015 Feb 3. doi: 10.1038/mp.2014.188. [Epub ahead of print].
Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB,
Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C; for the Health ABC study. Objective
measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behavior
and Brain Research. 2015 Feb 2. pii: S0166-4328(15)00062-5. doi: 10.1016/j.bbr.2015.01.045 [PMCID:
PMC4369426].
McDade E, Boot BP, Riverol M, Lopez O.Cerebral bleed after shunt for normal pressure hydrocephalus
with cerebral amyloid angiopathy: Coincidence or consequence? Neurology in Clinical Practice 2015 Jun;5
(3):263-266.
Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin
M, Lahti J, van der Lee SJ, Hellard SL, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith
JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris S, Hill WD,
Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Au R, Becker JT, Beiser A, Berr C,
Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, L De Jager P, Dufouil C, Eriksson JG,
Espeseth T, Faul JD, Ford I, Generation Scotland, Gottesman RF, Griswold ME, Gudnason V, Harris TB,
Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SLR, Kochan N, Knopman DS, Kwok JB, Lambert
JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS,
Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P,
Rotter J, Schmidt H, Schuur M, Schofield P, Scott R, Steen VM, Stott DJ, van Swieten JC, Taylor KD,
Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF,
Wright MJ, Yang Q, Amieva H, Attia J, Bennett DA, Brodaty H, de Craen AJM, Hayward C, Ikram MA,
Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R,
Schofield PS, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, Visscher PM, van Duijn C, Launer
L, Fitzpatrick AL, Seshadri S, Mosley TH, Deary1 IJ, General cognitive function in middle and older age
is associated with the APOE/TOMM40 and 12q13.2 genomic regions: meta-analyses of genome-wide
association studies (N = 53 949) in the CHARGE Consortium. Molecular Psychiatry. 2015 Feb 20(2): 183-
192 [PMCID: PMC4356746].
Mosley T, Ibrahim-Verbaas C, Bressler J, Debette S, Schuur M, Smith A, Bis J, Davies G, Trompet S,
Smith J,Wolf C, Chibnik L, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek K, Zgaga L, Hoffmann P,
Karjalainen, Lahti J, Llewellyn D, Schmidt C, Mather S, Chouraki V, Sun Q, Resnick S, Rose L,
Oldmeadow C, Stewart M, Smith B, Gudnason V, Yang Q, Mirza S, Jukema J, De Jager P, Harris T,
Liewald D, Amin D, Coker L, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai J, Becker JT,
Jonsdottir M, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner S, Yaffe K, Lohman K, vanSwieten
JC, Kardia S, Knopman D, Meeks D, Heiss G, Holliday E, Schofield P, Tanaka T, Stott D, Wang J,
171
Ridker P, Gow AJ, Pattie A, Starr J, Hocking L, Armstrong N, McLachlan N, Shulman J, Porteous D,
Pilling L, Eiriksdottir G, Scott R, Kochan N, Palotie A, Hsieh YC, Eriksson J, Penman A, Gottesman R,
Oostra B, Yu L, DeStefano A, Beiser A, Garcia M, Rotter J, Nöthen M, Hofman A, Slagboom P,
Westendorp R, Buckley B, Wolf P, Uitterlinden A, Psaty B, Joergen Grabe H, Bandinelli S, Chasman D,
Grodstein F, Raikkonen K, Lambert JC, Generation Scotland, Price J, Sachdev P, Ferrucci L, Attia J, Rudan
I, Hayward , Wright A, Wilson J, Cichon S, Franke L, Schmidt H, Ding J, De Craen A, Fornage M, Bennett
D, Deary I, Ikram M, Launer L, Fitzpatrick A, Seshadri S, van Duijn C, Fawns-Ritchie C. GWAS for
executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry,
in press.
Zeifman LE, Eddy WF, Lopez OL, Kuller LH, Raji C, Thompson PM, Becker JT. Voxel level survival
analysis of grey matter volume and incident mild cognitive impairment or Alzheimer’s disease. Journal of
Alzheimer’s Disease, 2015: 2015; 46 (1):167-178 [PMCID: PMC4550581]
Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA,
Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C,
Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick
SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager
PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I,
Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann RS, Herms S, Nalls M, Zhao W, Turner ST, Yaffe
K, Lohman K, van Swieten JC, Kardia SL, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield
PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ,
McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC,
Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI,
Nöthen MM, Hofman A, Slagboom PE, Westendorp RG, Buckley BM, Wolf PA, Uitterlinden AG, Psaty
BM, Grabe HJ, Bandinelli S, Chasman DI, Grodstein F, Räikkönen K, Lambert JC, Porteous DJ;
Generation Scotland, Price JF, Sachdev PS, Ferrucci L, Attia JR, Rudan I, Hayward C, Wright AF, Wilson
JF, Cichon S, Franke L, Schmidt H, Ding J, de Craen AJ, Fornage M, Bennett DA, Deary IJ, Ikram MA,
Launer LJ, Fitzpatrick AL, Seshadri S, van Duijn CM, Mosley TH. GWAS for executive function and
processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry 2015 Apr 14. doi:
10.1038/mp.2015.37. [Epub ahead of print].
Chen YL, Rosario BL, Mowrey W, Laymon CM, Lu X, Lopez OL, Klunk WE, Lopresti BJ, Mathis CA,
Price JC. PiB Relative Delivery (R1) as a Proxy of Relative Cerebral Blood Flow: Quantitative Evaluation
Using Single Session [15O]Water and [11C]PiB PET. Journal of Nuclear Medicine 2015 [Epub ahead of
print].
Ghani M, Reitz C, Cheng R, Vardarajan NB, Jun G, Sato C, Naj A, Rajbhandary R,Sanf LS, Valladares O,
Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane K, Buxbaum JD, Murrell J Raj T,
Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LS, Candwell L, Fallin L, Go RDCP, Griffith
P, Obisesan TO,D, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS,
Goate AM, Byrd GS, Kukull WA, Foroud TM, Heines JL, Farrer LA, Pericak-Vance M, Lee JH,
Schellenberg JD, St George-Hyslop P, MD, Mayeux R,, Rogaeva E for the Alzheimer Disease Genetics
Consortium. Association of Long Runs of Homozygosity with Alzheimer’s Disease among African
Americans. JAMA-Neurology, Nov 1; 72 (11):1313-1323 [PMCID: PMC4641052]
Yau WYW, BS, Tudorascu DL, PhD, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu
LK, Snitz BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL. Longitudinal
change of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: Exploring
across-group and within-individual progression. Lancet Neurology, 2015 Aug; 14 (8):804-813 {PMCID:
PMC4519011]
170
Kaycee Sink K, Espeland MA, Castro CM, Church T, Cohen, R, Dodson JA, Guralnik J, Hendrie HC,
Jennings J, Katula J, Lopez OL, McDermott M, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S,
Williamson J, for the LIFE Study investigators. Effect of a 24-month physical activity intervention
compared to health education on cognitive outcomes in sedentary older adults: the LIFE Randomized Trial.
Journal of the American Medical Association (JAMA) 2015; 314(8): 781-790. [PMCID: PMC4698980].
Gregg NM, Kim AE, Gurol ME, Lopez OL, Aizenstein HJ, Price J, Mathis C, James J, Snitz B, Cohen A,
Kamboh MI, Weissfeld L, Klunk WE. Cerebral microbleeds are associated with reduced cerebral blood
flow and metabolism but not amyloid in the very elderly, JAMA-Neurology 2015 Sep;72 (9):1021-1028
[PMCID: PMC4724412].
Metti A, Aizenstein H, Yaffe K, Boudreau R, Newman A, Launer L, Gianaros P, Lopez OL, Saxton J, Ives
DG, Kritchevsky S, Vallejo AN, Rosano C. Trajectories of peripheral interleukin-6, structure of the
hippocampus, and cognitive impairment over 14 years in older adults. Neurobiology of Aging 2015 Nov;
36 (11): 3038-3044. [PMCID: PMC4718400].
Laugsand LE, Ix JH, Bartz TM, Djousse L, Kizer JR, Tracy RP, Dehghan A, Rexrode K, Lopez OL, Rimm
EB, Siscovick DS, O'Donnell CJ, Newman A, Mukamal KJ,Jensen MK. Fetuin-A and risk of coronary
heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7
prospective studies. Atherosclerosis 2015; 243: 44-52 [PMCID: PMC4609621].
Snitz BE, Lopez OL, McDade E, Becker JT, Cohen AD, Price JC, Mathis CA, Klunk WE. Amyloid-β
imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study.
Journal of Alzheimers Disease. 2015 Sep 24; 48: Suppl 1:S151-159 [PMCID: PMC4675050].
Goodheart AE, Tamburo E, Minhas D, Aizenstein HJ, McDade E, Snitz BE, Price JC, Mathis CA, Lopez
OL, Klunk WE, Cohen AD. Reduced binding of Pittsburgh Compound-B in areas of white matter
hyperintensities. Neuroimage, Clinical. 2015 Sep 29; 9:479-483 [PMCID: PMC4600857].
Kuller LH, Lopez OL, Becker JT, Chang Y, Newman AB. Risk of dementia and death in the long-term
follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study. Alzheimers & Dementia. 2016
Feb; 12(2):170-183. Epub 2015 Oct 28 [PMCID: PMC4744537].
Ahdidan J, Raji CA, DeYoe EA, Mathis J, Noe KØ, Rimestad J, Kjeldsen TK, Mosegaard J, Becker JT,
Lopez O.Quantitative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR
Imaging. Journal of Alzheimers Disease. 2015; 49(3): 723-732. doi: 10.3233/JAD-150559 [PMCID:
PMC4718601].
Mosley T, Ibrahim-Verbaas C, Bressler J, Debette S, Schuur M, Smith A, Bis J, Davies G, Trompet S,
Smith J,Wolf C, Chibnik L, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek K, Zgaga L, Hoffmann P,
Karjalainen, Lahti J, Llewellyn D, Schmidt C, Mather S, Chouraki V, Sun Q, Resnick S, Rose L,
Oldmeadow C, Stewart M, Smith B, Gudnason V, Yang Q, Mirza S, Jukema J, De Jager P, Harris T,
Liewald D, Amin D, Coker L, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai J, Becker JT,
Jonsdottir M, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner S, Yaffe K, Lohman K, vanSwieten
JC, Kardia S, Knopman D, Meeks D, Heiss G, Holliday E, Schofield P, Tanaka T, Stott D, Wang J, Ridker
P, Gow AJ, Pattie A, Starr J, Hocking L, Armstrong N, McLachlan N, Shulman J, Porteous D, Pilling L,
Eiriksdottir G, Scott R, Kochan N, Palotie A, Hsieh YC, Eriksson J, Penman A, Gottesman R, Oostra B,
Yu L, DeStefano A, Beiser A, Garcia M, Rotter J, Nöthen M, Hofman A, Slagboom P, Westendorp R,
Buckley B, Wolf P, Uitterlinden A, Psaty B, Joergen Grabe H, Bandinelli S, Chasman D, Grodstein F,
Raikkonen K, Lambert JC, Generation Scotland, Price J, Sachdev P, Ferrucci L, Attia J,
172
Rudan I, Hayward , Wright A, Wilson J, Cichon S, Franke L, Schmidt H, Ding J, De Craen A, Fornage M,
Bennett D, Deary I, Ikram M, Launer L, Fitzpatrick A, Seshadri S, van Duijn C, Fawns-Ritchie C. GWAS
for executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry. 2016 Feb;21(2):189-197; {Epub 2015 Apr 14}. [PMCID: PMC 4722802].
Jun G, Ibrahim-Verbaas CA, Vronskaya M, PhD, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS,
Bis JC, Bellenguez C, Lunetta KL, Harold D, Destefano AL, Grenier-Boley B, Beecham GW, Smith AV,
Escott-Price V, Chouraki V, Hamilton-Nelson KL, Gerrish A, Ikram M, Fievet N, Martin ER, Sims R,
Schmidt H, Kamatani Y, Valladares O, Ruiz A, Zelenika D, Foroud TM, Choi SH, Boland A, Kukull WA,
van der Lee SV, Pasquier F, Beekly D, Fitzpatrick AL, Hanon O, Barber R, Gudnason V, Campion D,
Bennett DA, Amin N, Berr C, Buxbaum JD, Lopez OL, Deramecourt V, Cantwell LB, Tárraga L, Dufouil
C, Crane PK, Eriksdottir G, Hannequin D, Evans D, Mosley TH, Letenneur L, Goate AM, De Jager P,
Jakobsdottir J, Dartigues JF, Kamboh MI, de Bruijn RFAG, Tzourio C, Larson EB, Rotter J, Montine TJ,
Nalls MA, Reiman E, Jonsson P, St. George-Hyslop P,Boada M, Wendland JR, Schmidt R, Winslow AR,
Younkin SG, Hofman A, Wilhelmsen KC, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C,
Launer LJ, Mayeux R, Lathrop M, Holmans P, Seshadri S, Pericak-Vance M, Amouyel
P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer’s disease locus located near
the gene encoding tau protein. Molecular Psychiatry. 2016 Jan;21(1): 108-117 {Epub 2015 Mar 17}
[PMCID: PMC4573764].
Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, Lopez OL, Mahoney J,
Pasic J, Tan ZS, Wills CD, Rhoads R, Yager J. The American Psychiatric Association Practice Guideline
on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients with Dementia. American Journal
of Psychiatry. 2016 May 1;173(5): 543-546. doi: 10.1176/appi.ajp.2015.173501.
Kirkwood CA, MacDonald ML, Schempf TA, Vatsavayi A, Ikonomovic MD, Ding Y, Sun M, Kofler JK,
Lopez OL, Yates N, Sweet RA. Vilip-1 Levels altered in brain tissue of individuals with Alzheimer’s
disease and frontotemporal lobar degeneration with prominent neuronal loss. Journal of Neuropathology
and Experimental Neurology 2016; Jan 14. pii: nlv018. [Epub ahead of print].
Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PM,
Kestenbaum BR, Kuller LH, Lopez OL, Becker JT, Langa KM, Henley WE, Lang IA, Ukoumunne OC,
Llewellyn DJ. Vitamin D and memory decline: Two population-based prospective studies. Journal of
Alzheimer’s Disease 2016, Jan 21; 50(4): 1099-1108. doi: 10.3233/JAD-150811..
Kuller LH, Lopez OL. Cardiovascular disease and dementia risk: an ever growing problem in an aging
population. Expert Review in Cardiovascular Therapy. 2016 May 4. [Epub ahead of print].
Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic
MD, Lopez OL, Fitz NF, Koldamova R, Yates NA. APOE*4 genotype is associated with altered levels of
glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to
moderate Alzheimer disease. Molecular Cell Proteomics. 2016 Apr 21. pii: mcp.M115.056580. [Epub
ahead of print].
Chauhan G, Arnold CR, Chu AY, Fornage M, Reyahi A, Bis JC, Havulinna AS, Sargurupremraj M, Smith
AV, Adams HHH, Choi SH, Trompet S, Garcia ME, Manichaikul A, Teumer A, Gustafsson S, Bartz TM,
Bellenguez C, Vidal JS, Jian X,r Kjartansson O, Wiggins KL, Satizabal C, Xue F, Ripatti S, Liu Y, Deelen
J, den Hoed M, Bevan S, Hopewell J, Malik R, Heckbert SR, Rice K, Smith NL, Levi C, Sharma P, Sudlow
CLM, AM, Cole JW, Schmidt R, Meschia J, Thijs V, Lindgren A, Melander O, Grewal RP, Sacco RL,
Rundek T, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Markus HS, Wasssertheil-
Smoller S, Lee JM, Pulit SL, Wong Q, Aparicio HJ, Engelter ST, Kloss M, Leys D,
173
Pezzini A, Buring JE, Ridker PM, Berr C, Dartigues JF, Hamsten A, Magnusson PK, Pedersen NL, Lannfelt
L, Lind L, Lindgren CM, Morris AP, Jimenez-Conde J, Montaner J, Radmanesh F, Slowik A, Woo D,
Hofman A, Koudstaal PJ, Portegies ML, Uitterlinden AG, de Craen AJM, Ford I, Jukema JW, Stott DJ,
Allen NB, Sale MM, Johnson AD, Grabe AG, Markus MRP, Schminke U, Boncoraglio GB, Clarke R,
Dallongeville J, Worrall BB, Rosand J, Kamatani Y, Lopez OL, Rotter JI, Nalls MA, Gottesman RF,
Griswold ME, Knopman DS, Windham G, Beiser A, deStefano A, Vartiainen E, French CR, Dichgans M,
Lathrop M, Gudnason V, Kurth T, Psaty BM, Harris TB, Rich SS, Schmidt CO, Salomaa V, Mosley TH,
Ingelsson E, van Duijn CM, Launer LJ, Lehmann OJ, Tzourio C, Rexrode K, Ikram MA, Carlsson P,
Chasman DI, Childs SJ, Longstreth WT, Seshadri S, Debette S. FOXF2, a novel risk locus for stroke and
small artery disease. Lancet-Neurology, 2016 Jun;15(7):695-707 [PMCID: PMC4927887]
Raji C, Merrill DA, Eyre H, Mallam S, Torosyan N, Erickson KI, Lopez OL, Becker JT, Carmichael OT,
Gach HM, Thompson PM, Longstreth W, Kuller LH. Longitudinal relationships between caloric
expenditure and gray matter in the Cardiovascular Health Study. Journal of Alzheimer’s Disease. 2016;52(2):719-729 [PMCID: PMC4927887].
Rodakowski, J., Reynolds III, C. F., Lopez, O. L., Butters, M. A., Dew, M. A., Skidmore E. R. Developing
a non-pharmacological intervention for individuals with Mild Cognitive Impairment. Journal of Applied
Gerontology 2016 Apr 22. pii: 0733464816645808. [Epub ahead of print]
Ding Y, MacDonald ML, Kirkwood CM, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez
OL, Fitz NF, Koldamova R, Yates NA, Sweet RA. APOE*4 genotype is associated with altered levels of
glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild to
moderate Alzheimer’s disease. Molecular and Cellular Proteomics, in press.
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR;
Kuller LH, Langa KM, Lopez OL, Llewellyn DJ. Vitamin D and Risk of Neuroimaging Abnormalities.
PloS One 2016 May 11;11(5): e0154896. doi: 10.1371/journal .pone.0154896.eCollection 2016 [PMCID:
PMC4864237
Kuller LH, Lopez OL, Mackey RH, Rosano C, Edmundowicz D, Becker JT, Newman AB. Subclinical
Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years. Journal of the American College of Cardiolology. 2016 Mar 8; 67 (9):1013-1022. doi: 10.1016/j.jacc.2015.12.034.
Sharma M, Fitzpatrick AL, Arnold AM, Chi G, Lopez OL, Jenny NS, DeKosky ST. Inflammatory
biomarkers and cognitive decline: The Ginkgo Evaluation of Memory Study. Journal of the American
Geriatric Society. 2016 Jun; 64(6):1171-1177.
Boeve BF, Dickson DW, Duda JE, Ferman TJ, Galasko DR, Galvin JE, Goldman JG, Growdon JH, Hurtig
HI, Kaufer DI, Kantarci K, Leverenz JB, Lippa CF, Lopez OL, McKeith IG, Singleton AB, Taylor A,
Tsuang D, Weintraub D, Zabetian CP. Arguing against the proposed definition changes of Parkinson’s
Disease. Movement Disorders, in press.
Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi
SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B,
Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn
C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S; International
Genomics of Alzheimer’s Project. Evaluation of a Genetic Risk Score to Improve Risk Prediction for
Alzheimer's Disease. Journal of Alzheimers Disease. 2016 Jun 18. [Epub ahead of print].
174
Chi GC, Fitzpatrick AL, Sharma M, Jenny NS, Lopez OL, DeKosky ST.Inflammatory Biomarkers Predict
Low Domain-Specific Cognitive Function in Older Adults. Journal of Gerontology: Medical Sciences,
2016, Aug 13, DOI: 10.1093/Gerona/glw155
Nadkarni NK, Perera S, Snitz BE, Price J, Mathis CA,Williamson JD, DeKosky ST, Klunk, WE, Lopez
OL. Cortical amyloid-beta and slow Gait in older adults without dementia: Influence of cognition and
APOE genotype. JAMA-Neurology, 2017 Nov 8; 87(19):1993-1999 [PMCID: PMC5209955].
Spauwen PJJ, Murphy RA, Jonsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MPJ, Lopez
OL, Gudnason V, Harris TB, Launer, LJ. Associations of fat and muscle tissue with cognitive status in a
population-based cohort of older adults: The AGES-Reykjavik Study. Age and Ageing, in press.
Reid KF, Walkup MP, Katula JA, Sink KM, Anton S, Axtell R, Kerwin DR, King AC, Kramer AF,
Miller ME, Myers V, Rosano C, Studenski SA, Lopez OL, Verghese J, Fielding RA, Williamson J.
Cognitive performance does not limit physical activity participation in the Lifestyle Interventions
and Independence for Elders pilot study (LIFE-P). Journal of Prevention of Alzheimer’s Disease
2016; 3(2): 66-67.
Grill JD, Apostolova L, Bullain S, Burns J, Cox C, Dick M, Kawas C, Kremen S, Lingler J, Lopez OL,
Mapstone M, Pierce A, Rabinovivi G, Roberts S, Sajjadi A, Teng E, Karlawish J. Communicating Mild
Cognitive Impairment diagnosis with and without amyloid imaging. Neurology, in press.
Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez
A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis
K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton
SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching
CRK, Chouraki V, Crivello F, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Giddaluru S, Goldman
AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Höhn D,
Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein
M, Kraemer B, Krämer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand A, Matarin
M, Karen A Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Maniega SM, Nho K, Nugent AC,
Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS,
Saremi A, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann
PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT,
Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der
Lee SJ, van der Meer D, Van Donkelaar MMJ, Van Eijk KR, van Erp TGM, van Rooij D, Walton E,
Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T,
Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA,
Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van
Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva
KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A,
Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager
PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A,
Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO,
Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C,
Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HHH, Green RC, Gruber O, Gudnason V, Guelfi
S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Hellard SL,
Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G,
Hosten N, Hottenga JJ, Huentelman M, Pol HEH, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson
EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I,
175
Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone
S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL,
Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH,
Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg
L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG,
Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco
RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A,
Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga
AW, Traynor B, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MCV, Van 't Ent D, Van
der Brug M, Van der Lugt A, Van der Wee NJA, Van Haren NEM, Van Tol MJ, Vardarajan BN, Vellas B,
Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW,
Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, The Alzheimer’s
Disease Neuroimaging Initiative, EPIGEN, IMAGEN, SYS, Martin NG, Van Duijn CM, Wright MJ,
Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM,
Ikram MA. Novel genetic loci associated with hippocampal volume, shape, and subfields. Nature
Communications 2017 Jan 18; 8:13624 [PMCID: PMC5253632].
Jakobsdóttir J, van der Lee SJ, Bis JC, Chouraki V, Shulman JM, Grove ML, Naj A, Vronskaya M,
DeStefano AL, Brody JA, Smith AV, Amin N, Ibrahim-Verbaas CA, Choi SH, Lopez OL, Beiser A, Ikram
MA, Garcia ME, Eirkisdottir G, Rice K, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T,
Cohorts for Heart and Aging Research in Genomic Epidemiology, Alzheimer’s Disease Genetic
Consortium, Genetic and Environmental Risk in Alzheimer’s Disease, International Genetics Alzheimer’s
Project, O’Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg J,
Boerwinkle E, Psaty B, Seshadri S, Gudnason V, van Duijn CM. Rare missense variant in TM2D3 is
associated with risk and onset of late-onset Alzheimer’s disease. PLOS Genetics 2016 Oct 20; 12(10):
e1006327 [PMCID: PMC5072721].
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A,
Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini
S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A,
Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM,
Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan
NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold
ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz
D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano
M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter
R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM,
Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS,
Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL,
Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A,
Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D,
Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD,
Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos
A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S,
Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H,
Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W,
Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-
Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty
N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD,
Erk S, Espeseth T, Evans DA, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I,
Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL,
176
Göring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA,
Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra
PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Pol HE, Ikeda M, Ikram MK,
Jack CR Jr, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman
DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Longstreth WT Jr, Lopez OL,
Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon
FJ, Mecocci P, Melle I, Meyer-Lindenber A, Mohnke S, Mongomery GW, Morris DW, Mosley TH,
Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg
L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG,
Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco
RL, Sachdev PS, Saykin AJ, Schmidt R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya
SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A,
Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hernández MC,
Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van T Ent D, Van Tol
MJ, Vardarajan BN, Veltman DJ, Vernooij MW, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale
ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR,
Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ,
Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ikram MA, Thompson PM. Novel genetic
loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience 2016 Dec; 19 (12):1569-1582 [PMCID: PMC5253632].
Nadkarni NK, Lopez OL, Studentship SA, Snitz BE, Perera S, Erickson KI, Mathis CA, Nebeks RD,
Redfern M, Klunk WE, MD, PhD2,3. The Cognition-Mobility interface is associated with cerebral amyloid
in older adults without cognitive or mobility impairment. Journal of Gerontology Series A: Biological
sciences and Medical Sciences 2016 Nov 1. doi: 10.1093/ gerona/glw211.
Weamer EA, DeMichele-Sweet MA, Cloonan YK, Lopez OL, Sweet RA. Incident psychosis in subjects
with Mild Cognitive Impairment or Alzheimer's disease. Journal of Clinical Psychiatry. 2016 Dec; 77 (12):
e1564-e1569. doi: 10.4088/JCP.15m10617.
Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SE, Lee, Vivianna EB, Van Deerlin M,
Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D,
Longfellow K, Yearout D, Kukul Wl, Keene CD, Montine TJ, Zabetian CP, Trojanowski JT.
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a
retrospective analysis. Lancet-Neurology 2017 Jan; 16(1):55-65 [PMCID: PMC5181646].
Boada M, Anaya F, Ortiz P, Olazarán J, Hernández I, Muñoz J, Buendia M, Alegret M, Lafuente A, Tárraga
L, Núñez L, Torres M, Grifols JR, Ferrer I, Obisesan TO, Shua-Haim JR, Lopez OL, Páez A. Plasma
exchange with 5% albumin alters Aβ levels in CSF and plasma, and improves cognition in Alzheimer’s
disease patients. Journal of Alzheimer’s Disease 2017, 56(1):129-143 [PMCID: PMC5240541].
Slachevsky A, Guzmán-Martínez L, Delgado C, Reyes P, Farías GA, Muñoz C, Bravo E, Farías M, Flores
P, Garrido C, Becker JT, López OL, Maccioni RB. TAU Platelets correlates with regional brain atrophy
in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease. 2017; 55 (4):1595-1603. doi:
10.3233/JAD-160652.
Spauwen PJJ, Murphy RA, Jonsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MPJ, Lopez
OL, Gudnason V, Harris TB, Launer, LJ. Associations of fat and muscle tissue with cognitive status in a
population-based cohort of older adults: The AGES-Reykjavik Study. Age and Ageing 2017 Mar 1; 46(2):
250-257 [PMCID:PMC5386007].
177
Ding J, Sigurŏsson S, Jónsson PV, Eirksdottir, Meirelles O, Kjartansson O, Lopez OL, van Buchem M,
Gudnason, Launer L. Space and location of cerebral microbleeds, cognitive decline, and dementia in the
community: The AGES-Reykjavik Study. Neurology, 2017. May 30;88 (22):2089-2097.
Nadkarni NK, Perera S, Snitz BE, Price J, Mathis CA, Williamson JD, DeKosky ST, Klunk, WE, Lopez
OL. Cortical amyloid-beta and slow gait in older adults without dementia: Influence of cognition and
APOE genotype. JAMA Neurology 2017 Jan 1; 74 (1):82-90. doi: 10.1001 /jamaneurol.2016.3474.
Kassen AM, Ganguli M, Yaffee K, Hanlon JT, Lopez OL, Wilson JW, Cauley JA. Anxiety symptoms and
risk of cognitive decline in older community-dwelling men: results from the Osteoporotic Fractures in Men
Study. International Psychogeriatric 2017 Apr 9:1-9. doi: 10.1017/S104161021700045X.
Kuźma E, Airdrie J, Littlejohns TJ, Lourida I, Thompson-Coon J, Lang IA, Scrobotovici M, Thacker E,
Fitzpatrick A, Kuller LH, Lopez OL, Longstreth WT, Ukoumunne OC, Llewellyn DJ. Coronary artery
bypass graft surgery and the risk of dementia: A prospective study and meta-analysis. Alzheimer’s Disease
and Associated Disorders 2017 Mar 3. doi: 10.1097/WAD. 0000000000000191. [Epub ahead of print].
DeMichele-Sweet MA, Weamer EA, Klei L, Vrana DT, Hollingshead DJ, Seltman HJ, Sims R, Foroud T,
Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL,
Kamboh MI, Devlin B, Sweet RA. Genetic risk for schizophrenia and psychosis in Alzheimer’s disease.
Biological Psychiatry, in press.
Stillman CM, Lopez OL, Becker JT, Kuller LH, Mehta PD, Tracy RP, Erickson KI. Physical activity
reduces plasma β amyloid levels and decreases risk for cognitive impairment in older adults: Longitudinal
results from the Cardiovascular Health Study. Annals of Clinical and Translational Neurology, 2017 Apr
14;4 (5):284-291 [PMCID:PMC5420805].
Kassem AM, Hanlon J, Ganguli M, Yaffe K, Wilson JW, Lopez OL, Ayonayon OE, O'Hare C, Satterfield
S, Harris TB, Cauley JA. Trends and gender-specific predictors of anxiolytic and antidepressant
medications use in older adults. Aging and Mental Health, in press.
Grill JD, Apostolova L, Bullain S, Burns J, Cox C, Dick M, Kawas C, Kremen S, Lingler J, Lopez OL,
Mapstone M, Pierce A, Rabinovivi G, Roberts S, Sajjadi A, Teng E, Karlawish J. Communicating Mild
Cognitive Impairment diagnosis with and without amyloid imaging. Alzheimer’s Research & Therapy
2017, in press.
Palta P, Carlson MC, Crum RM, Colantuoni E, Sharrett AR, Yasar S, Nahin R, DeKosky ST, Snitz B,
Lopez OL, Williamson JD, Furberg CD, Rapp SR, Golden SH. Diabetes and Cognitive Decline in Older
Adults: The Ginkgo Evaluation of Memory Study. Journal of Gerontology: Medical Sciences, in press.
Ding J, Sigurðsson S, Jónsson PV, Eiriksdottir G, Charidimou A, Lopez OL, van Buchem MA, Guðnason
V, Launer LJ. Large MRI-visible perivascular spaces, cerebral small vessel disease progression and risk of
dementia: the AGES-Reykjavik Study. JAMA-Neurology, in press.
Petersen RC, Lopez OL, Armstrong M, Getchius TS, Ganguli M, Gloss, D, Marson D, Pringsheim T, Day
GS, Sager M, Stevens JC, Rae-Grant AD. American Academy of Neurology Practice guideline for mild
cognitive impairment. Neurology, in press.
Zhao J, Tudorascu DL, Lopez OL, Cohen AD, Price JC, Mathis CA, Aizenstein HJ, Kuller LH, DeKosky
ST, Klunk WE, Snitz BE. Amyloid-beta deposition and suspected non-Alzheimer
178
pathophysiology exhibit different cognitive decline patterns over 12 years in the oldest-old without
dementia. JAMA-Neurology, in press.
Beth Snitz, PhD
Snitz BE, Weissfeld LA, Cohen AD, Lopez OL, Nebes RD, Aizenstein HJ, McDade E, Price JC, Mathis
CM, Klunk WE. Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal
older adults. American Journal of Geriatric Psychiatry, in press, doi:10.1016/j.jagp.2015.01.008.
Snitz BE, Lopez OL, McDade E, Becker JT, Cohen AD, Price JC, Mathis CA, Klunk WE. Amyloid beta
imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study.
Journal of Alzheimer’s Disease, 2015, 48, S151-S159.
Rosenthal SL, Bamne MN, Wang X, Berman S, Snitz BE, Klunk WE, Sweet RA, Demirci FY, Lopez OL,
Kamboh MI. More evidence for association of a rare TRAM2 mutation (R47H) with Alzheimer’s disease
risk. Neurobiology of Aging. 2015 Aug; 36 (8):2443.e21-6. PMCID: PMC4465085. PMIC: 26058841.
Doi:10.1016/j.neurogioaging.2015.04.012.
Yau WW, Tudorascu DL, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu LK, Snitz
BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL, Klunk WE. Longituinal
assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a
prospective cohort study. The Lancet. Neurology. 2015 June 29. PMIC: 26139022. Doi: 10.1016/S1474-
4422(15)00135-0.
Snitz, BE, Small, B. J., Wang, T., Chang, C. C. H., Hughes, T. F., & Ganguli, M. Do subjective memory
complaints lead or follow objective cognitive change? A five-year population study of temporal influence.
Journal of the International Neuropsychological Society, 2015, 21(09), 732-742.
Nimgaonkar, V. L., Yolken, R. H., Wang, T., Chung-Chou, H. C., McClain, L., McDade, E., Snitz BE, &
Ganguli, M. Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-
based, Aging Cohort. Alzheimer Disease and Associated Disorders. 2015.
doi:10.1097/WAD.0000000000000133.
Rabin, L. A., Smart, C. M., Crane, P. K., Amariglio, R. E., Berman, L. M., Boada, M., Buckley, R.,
Chetalat, G., Dubois, B., Ellis, K.A., Gifford, K.A., Jefferson, A.L., Jessen, F., Katz, M.J., Lipton, R.B.,
Perrotin, A., Petersen, R.C., Rami, L., Reisberg, B., Rentz, D.M., Reidel-Heller, SG., Risacher, S.L.,
Rodriquez, O., Sachdev, P.S., Saykin, A.J., Slavin, M.J., Snitz, B.E., Sperling, R.A., Tandetnik, C., Van
der Flier, W.M., Wagner, M., Wolfsbruber, S., & Sikkes. Subjective Cognitive Decline in Older Adults:
An Overview of Self-Report Measures Used Across 19 International Research Studies. Journal of
Alzheimers Disease, 2015, 48, S63-S86. doi:10.3233/JAD-150154.
Callahan, K. E., Lovato, J. F., Miller, M. E., Easterling, D., Snitz, B., & Williamson, J. D. Associations
Between Mild Cognitive Impairment and Hospitalization and Readmission. Journal of the American Geriatrics Society, 2015, 63(9), 1880-1885.
Gregg, N. M., Kim, A. E., Gurol, M. E., Lopez, O. L., Aizenstein, H. J., Price, J. C., Mathis, C.A., James,
J.A. Snitz, B.E., Cohen, A.D., Kamboh, I., Minhas, D., Weissfeld, L.A., Tamburo, E., & Klunk, W. E.
Incidental cerebral microbleeds and cerebral blood flow in elderly individuals. JAMA Neurology, 2015,
72(9), 1021-1028. doi:10.1001/jamaneurol.2015.1359.
Fowler, N. R., Morrow, L., Chiappetta, L., Snitz, B., Huber, K., Rodriguez, E., & Saxton, J. Cognitive
testing in older primary care patients: A cluster-randomized trial. Alzheimer's and Dementia: Diagnosis,
Assessment and Disease Monitoring, 2015, 1(3), 349-357. doi:10.1016/j.dadm.2015.06.009.
179
Wollam, M. E., Weinstein, A. M., Saxton, J. A., Morrow, L., Snitz, B., Fowler, N. R., . . . Erickson, K. I.
Genetic Risk Score Predicts Late-Life Cognitive Impairment. Journal of Aging Research, 2015.
doi:10.1155/2015/267062.
Goodheart, A. E., Tamburo, E., Minhas, D., Aizenstein, H. J., McDade, E., Snitz, B. E., . . . Cohen, A. D.
Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities. Neuroimagine-Clinical, 2015, 9, 479-483. doi:10.1016/j.nicl.2015.09.009.
McDade, E., Sun, Z., Lee, C. -W., Snitz, B., Hughes, T., Chang, C. -C. H., & Ganguli, M. The association
between pulse pressure change and cognition in late life: Age and where you start matters. Alzheimers
Dement (Amst), 2016, 4, 56-66. doi:10.1016/j.dadm.2016.03.008.
Graziane, J. A., Beer, J. C., Snitz, B. E., Chang, C. -C. H., & Ganguli, M. Dual Trajectories of Depression
and Cognition: A Longitudinal Population-Based Study. American Journal of Geriatric Psychiatry, 2016,
24(5), 364-373. doi:10.1016/j.jagp.2015.08.001.
Mattos, M. K., Snitz, B. E., Lingler, J. H., Burke, L. E., Novosel, L. M., & Sereika, S. M. Older Rural- and
Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health. 2016
doi:10.1111/jrh.12189.
Epilepsy Division
Anto Bagić, MD, PhD, Associate Professor and Chief, Epilepsy Division
Bagić A, Ebersole J. Does MEG/MSI Dipole Variability Mean Unreliability? Bagić A, Ebersole JS. Does
MEG/MSI dipole variability mean unreliability? Clin Neurophysiol 2015;126(1):209-11.
Maestu F. Peña JM, Garces P, Gonzalez s, Bajo R, Bagic A, Cuesta P, Funke M, Mäkelä J, Menasalvas E,
Nakamura A, Parkkonen L, Lopez ME, del Pozo F, Sudre S, Zamrini E, Pekkonnen E, Henson H, Becker
J. A Multicenter Study of the Early Detection of Synaptic Dysfunction in Mild Cognitive Impairment using
Magnetoencephalography-derived Functional Connectivity. Neuroimage Clin 2015;9:103-9.
Hendrickson R, Popescu A, Ghearing G, Bagić A. Thoughts, Emotions and Dissociative Features
Differentiate Patients with Epilepsy and Psychogenic Nonepileptic Spells (PNES). Epilepsy Behav
2015;51:158-62.
Bagić A. Look Back To Leap Forward: Additional Emerging Role Of Magnetoencephalography (MEG)
In Nonlesional Epilepsy. Clin Neurophysiol 2016;127(1):60-6.
Fisher RS, Afra P, Macken M, Daniela N. Minecan DN, Bagić A, Benbadis SR, Helmers SL, Sinha SR,
Slater J, Treiman D, Begnaud J, Raman P, Najimipour B. Performance and Clinical Outcomes of a Vagus
Nerve Stimulator triggered by Ictal Tachycardia: The US E-37 Trial. Neuromodulation 2016;19(2):188-
95.
Zhang J, Li X, Foldes S, Wang W, Collinger J, Weber DJ, Bagić A. Region-of-Interest-Constrained
Discriminant Analysis for MEG Decoding. IEEE Trans Biomed Eng 2016;63(1):30-42.
Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bagic A, Wagner
D, Richardson RM. Short-term neurocognitive outcomes following anterior temporal lobectomy. Epilepsy
Behav 2016, EB-16-144R1, in press.
180
Arun Antony, MD, Assistant Professor
Arun Angelo Patil, Arun Antony, Richard Andrews. Efficacy of Vagal nerve stimulation after multiple
sub pial transection in Epilepsy. World federation of Neurology
Arun Antony, AV Alexopoulos, JA Gonzalez-Martinez, JC Mosher, L Jehi. Functional Connectivity
Estimated from Intracranial EEG Predicts Surgical Outcome in Intractable Temporal Lobe Epilepsy, PloS
one 8 (10), e77916.
Philip S Lee, Jamie Pardini, Rick Hendrickson, Vincent Destefino, Alexandra Popescu, Gena Ghearing,
Arun Antony, Jullie Pan, MD, Anto Bajic, Danielle Wagner, Robert M Richardson. Short-term
neurocognitive outcomes following anterior temporal lobectomy. Epilepsy and behavior September 2016 (62):140–146. Sanjay Singh, Ram Sankaraneni, Arun Antony. Evidence Based Guidelines for the Management of
Epilepsy. Neurology India 2017: 65 (7); S6-11.
Zulfi Haneef, Sharon Chiang, Holly Rutherford, Arun Antony. A Survey of Neruophysiology Fellows in
the United States. Journal of Clinical Neurophysiology 2017: 34 (2) 179-186.
Thomas A Wozny, BSc; Witold J Lipski, PhD; Ahmad Alhourani, MD; Efstathios D Kondylis, BSE; Arun
Antony, Robert Mark Richardson. Effects of hippocampal low-fequency stimulation in idiopathic non-
human primate epilepsy assessed bia a remote-sensing-enabled neurostimulator. Journal of Experimental
Neurology.2017 (2094) 68-77.
Joanna Fong, Assistant Professor
Nancy Foldvary-Schaefer, Joanna S. Fong, Shannon Morrison, Lu Wang, James Bena. Lacosamide
Tolerability in Patients with Partial-Onset Seizures: Impact of Planned Reduction and Mechanism of
Action of Concomitant Antiepileptic Drugs. Epilepy Behav. 2016 Apr;57:155-160.
Gena Ghearing, MD, Assistant Professor
Kenmuir C, Richardson M, Ghearing G. Surgical treatment for medically refractory focal epilepsy in a
patient with fragile X syndrome. Brain Dev. 2015 Apr 7. pii: S0387-7604(15)00034-0. doi:
10.1016/j.braindev.2015.02.009. [Epub ahead of print]
Rick Hendrickson, PhD, Assistant Professor
Hendrickson, R., Popescu, A., Ghearing, G. & Bagic, A. (2015). Thoughts, emotions and dissociative
features differentiate patients with epilepsy from patients with psychogenic nonepileptic spells. Epilepsy & Behavior, 51, 158-62.
Lee, PS, Pardini, J., Hendrickson, R., Destefino, V., Popescu, A., Ghearing, G., Antony, A., Pan, J., Bagic,
A., Richardson, R.M. (accepted by Epilepsy & Behavior) Short-term neurocognitive outcomes following
anterior temporal lobectomy.
Alexandra Urban, MD, Assistant Professor
Edilberto Amorim, MD1; Jon C. Rittenberger, MD2; Maria E. Baldwin, MD1; Clifton W. Callaway, MD2;
Alexandra Popescu, MD1 And the Post Cardiac Arrest Service. Malignant EEG patterns in
181
cardiac arrest patients treated with targeted temperature management who survive to hospital discharge.
Resuscitation 2015, May:90:127-32.
Hendrickson R, Popescu A, Ghearing G, Bagic A. Thoughts, emotions, and dissociative features
differentiate patients with epilepsy from patients with psychogenic nonepileptic spells (PNESs). Epilepsy
Behav. 2015 Oct;51:158-62.
Elmer J, Rittenberger JC, Faro J, Molyneaux BJ, Popescu A, Callaway CW, Baldwin M; Pittsburgh Post-
Cardiac Arrest Service. Clinically distinct electroencephalographic phenotypes of early myoclonus after
cardiac arrest: EEG Phenotypes of PAMM. Ann Neurol. 2016 Jun 28. doi: 10.1002/ana.24697. [Epub
ahead of print]
Jamie Pardini, PhD; Rick Hendrickson, PhD; Vincent Destefino, BA; Alexandra Popescu, MD; Gena
Ghearing, MD; Arun Antony, MD; Jullie Pan, MD, PhD; Anto Bajic, MD, PhD; Danielle Wagner, PA-C;
Robert M Richardson, MD, PhD. Short-term neurocognitive outcomes following anterior temporal
lobectomy. Accepted in Epilepsy & Behavior.
Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bagic A,
Wagner D, Richardson RM.. Short-term neurocognitive outcomes following anterior temporal lobectomy.
Epilepsy Behav. 2016 Sep;62:140-6. doi: 10.1016/j.yebeh.2016.06.019
Amorim E, Rittenberger JC, Zheng JJ, Westover MB, Baldwin ME, Callaway CW, Popescu A; Pittsburgh
Post Cardiac Arrest Service. Continuous EEG monitoring enhances multimodal outcome prediction in
hypoxic-ischemic brain injury. Resuscitation. 2016 Dec;109: 121-126. doi: 10.1016/ j.resuscitation.
2016.08.012
Ghearing G, Abramovici S, Baldwin M, Urban A. Misleading EEG Lateralization Associated with
Midline Shift. Journal of Clinical Neurophysiology. 2017 Jul 4.. [Epub ahead of print]
Anne Van Cott, MD, Associate Professor
Rohde NN, Baca CB, Van Cott AC, Parko KL, Amuan ME, Pugh MJ. Antiepileptic drug prescribing
patterns in Iraq and Afghanistan war veterans with epilepsy. Epilepsy Behav.2015 46:133-9.
Pugh MJ, Van Cott AC, Amuan M, Baca C, Rutecki P, Zack MM, Kobau R. Epilepsy Among Iraq and
Afghanistan War Veterans-United States, 2002-2015. MMWR 2016 65 (44) 1224-1227.
Atalib H, Cavazos J, Pugh MJ, Hussain A, Kelly-Foxworth P, Tran T, Krumholz A, LaFrance WC, Lopez
R, Rutecki P, Van Cott A for the VA Epilepsy Centers of Excellence. Providing Quality Epilepsy Care
for Veteran. Fed Pract. 2016 September; 33 (9): 26-32.
Kontos AP, Van Cott AC, Roberts J, Pan JW, Kelly MB, McAllister-Deitrick J, Hetherington HP.
Clinical Biomarkers and Magnetic Resonance Spectroscopic Imaging Abnormalities in Veterans with
Blast Mild Traumatic Brain Injury and Post-traumatic Stress Disorder. Military Medicine
General Division
Neil Busis, MD, Clinical Professor
Busis NA, Dorsey ER. Shining light on Medicare’s values: The Medicare physician data release.
Neurology. 2015; 84:1730–1731.
182
Yanofsky CS, Busis NA. To revitalize neurology we need to address physician burnout. Neurology. 2015;
84(23):2384-5.
Satya-Murti S, Busis NA. Chronic care management codes: a small step in the right direction. Neurol
Clin Pract. 2015; 5:371-373.
Rolan TD, Busis NA, Dorsey ER. Shining light on Medicare's values: The Medicare physician data
release/ Author Response. Neurology. 2015; 85:1636.
Franklin GM, Busis NA. The AAN and the triple aim. Neurology. 2016; 86:114-5.
Busis NA, Franklin GM. The AAN's Axon Registry: Mastering how we are measured. Neurology. 2016;
87:2180–2181.
Busis NA, Shanafelt TD, Keran CM, Levin KH, Schwarz HB, Molano JR, Vidic TR, Kass JS, Miyasaki
JM, Sloan JA, Cascino TL. Burnout, career satisfaction, and well-being among US neurologists in 2016.
Neurology. 2017; 88:797–808.
Levin KH, Shanafelt TD, Keran CM, Busis NA, Foster LA, Molano JR, O’Donovan CA, Ratliff JB,
Schwarz HB, Sloan JA, Cascino TL. Burnout, career satisfaction, and well-being among US neurology
residents and fellows in 2016. Neurology. 2017; 89:492-501.
Busis NA, Shanafelt TD, Keran CM, Levin KH, Schwarz HB, Molano JR, Vidic TR, Kass JS, Miyasaki
JM, Sloan JA, Cascino TL. Author response: Burnout, career satisfaction, and well-being among US
neurologists in 2016. Neurology. 2017; 89:1650-1651.
Miyasaki JM, Rheaume C, Gulya L, Ellenstein A, Schwarz HB, Vidic TR, Shanafelt TD, Cascino TL,
Keran CM, Busis NA. Qualitative study of burnout, career satisfaction, and well-being among US
neurologists in 2016. Neurology. 2017; 89:1730-1738.
Angela Lu, MD, Clinical Associate Professor
Gonzalez NL, Puwanant A, Lu A, Marks SM, and Zivkovic SA. Myasthenia triggered by immune checkpoint
inhibitors: new case and literature review. Neuromuscular Disorders, 2017; 27 (3) 266-268.
Janet Waters, MD
Waters JH, Dyga RM, Waters JFR, Yazer MH. The volume of returned RBCs in a Large Blood Salvage
Program: Where does it all go? Transfusion. [Epub ahead of print].
Movement Disorders Division
Sarah Berman, MD, PhD, Assistant Professor
Van Laar VS, Roy N, Liu A, Rajprohat S, Arnold B, Dukes AA, Holbein CD, and Berman SB. (2015)
Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of
Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol. Dis, 74: 180-193.
Rosenthal SL, Bamne MN, Wang X, Berman S, Snitz BE, Klunk WE, Sweet RA, Demirci FY,
Lopez OL, and Kamboh MI (2015). More evidence for association of a rare TREM2 mutation
(R47H) with Alzheimer’s disease risk. Neurobiol. Aging, 36 (8):2443.e21-6.
183
Van Laar VS, Berman SB, and Hastings TG (2016). Mic60/mitofilin overexpression alters
mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and
rotenone. Neurobiol. Dis., (91) 247-261.
Dukes AD, Bai Q, Van Laar VS, Zhou Y, Ilin V, David CN, Agim ZS, Bonkowsky JL, Cannon JR,
Watkins SC, St. Croix CM, *Burton EA, and *Berman SB (2016) Live imaging of mitochondrial
dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial
transport following MPP+ exposure. Neurobiol. Dis., (95:238-49). *Co-corresponding authors.
Edward A. Burton, MD, DPhil, Assistant Professor
Zharikov, A., Cannon, J. R., Tapias, V., Bai, Q., Horowitz, M. P., Shah, V., El Ayadi, A., Hastings, T. G.,
Greenamyre, J. T., *Burton, E. A. (2015) shRNA targeting α-synuclein prevents neurodegeneration in a
Parkinson’s disease model. Journal of Clinical Investigation. 125(7):2721-2735.
[Featured as a “Scientific Show Stopper” with accompanying commentary on JCI website]
Keatinge, M., Bui, H., Menke, A., Chen, Y.-C., Sokol, A. M., Bai, Q., Ellett, F., Da Costa, M., Burke, D.,
Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.-S.,
Fleming, A., Schapira, A., Renshaw, S., Highley, J., R., Chacinska, A., Panula, P., Burton, E. A., O'Neil,
M., Bandmann, O. (2015) Early inflammation and alpha-synuclein-independent cell death in
glucocerebrosidase 1 deficient Danio rerio. Human Molecular Genetics. 24(23):6640-52.
Mahoney, S., Najera, M., Bai, Q., Burton, E. A., Veser, G. (2016) The developmental toxicity of complex
silica-embedded nickel nanoparticles is determined by their physicochemical properties. PLoS ONE
11(3):e0152010.
Di Maio, R. Barrett, P. J., Hoffman, E. K., Barrett, C. W., Zharikov, A., Borah, A., Hu, X., McCoy, J.,
Chu, C. T., Burton, E. A., Hastings, T. G., Greenamyre, J. T. (2016) α-Synuclein binds TOM20 and
inhibits mitochondrial protein import in Parkinson’s disease. Science Translational Medicine.
8:342ra78:1-14.
Dukes, A. D., Bai, Q., Van Laar, V. S., Zhou, Y., Ilin, V., David, C. N., Agim, Z. S., Bonkowsky, J.
L., Cannon, J. R., Watkins, S. C., St. Croix, C. M., *Burton, E. A. and Berman, S. B. (2016) Live
imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early
reversal of mitochondrial transport following MPP+ exposure. Neurobiology of Disease 95:238-249
[Burton E. A. and Berman S. B. are joint corresponding authors]
Burton, C. E., Zhou, Y., Bai, Q. & *Burton, E. A. (2017). Spectral properties of the zebrafish visual
motor response. Neurosci Lett 646, 62-67.
Sandulescu, M. C., and *Burton, E. A. (2017) Chapter 13: Movement Disorders Emergencies and
Movement Disorders in the ICU. In Neurocritical Care (Pittsburgh Critical Care Series), B.
Molyneux and L. Shutter eds. (Oxford: Oxford University Press) In press
Franca Cambi, MD, PhD, Professor of Neurology
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz
K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ,
Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N,
184
Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST,
Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS,
Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills
AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a
randomized clinical trial. JAMA. 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120.
GM1 ganglioside in Parkinson’sdisease: Pilot study of effects on dopamine transporter binding. Schneider
JS, Cambi F, Gollomp SM, Kuwabara H, Brašić JR, Leiby B, Sendek S, Wong DF. J Neurol Sci. 2015
Sep 15;356(1-2):118-23. doi: 10.1016/j.jns.2015.06.028. Epub 2015 Jun 16.
Pioglitazone in early Parkinson’s disease: a phase 2, multicentre, double-blind, randomised trial. NINDS
Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators. Lancet Neurol. 2015
Aug;14(8):795-803. doi: 10.1016/S1474-4422(15)00144-1. Epub 2015 Jun 23.
Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease. Augustine EF, Pérez A, Dhall
R, Umeh CC, Videnovic A, Cambi F, Wills AM, Elm JJ, Zweig RM, Shulman LM, Nance MA,
Bainbridge J, Suchowersky O. PLoS One. 2015 Jul 14;10(7):e0133002. doi:
10.1371/journal.pone.0133002. eCollection 2015.
Distinct and shared molecular targets and functions of ALS-associated TDP43, FUS and TAF15 revealed
by comprehensive multi-system integrative analyses. Kapeli K, Pratt G, Vu A, Martinez F, Freese P,
Lambert NJ, Hutt K, Sundaraman B, Huelga SC, Chun S, Liang S, Cheang J, Donohue JP, Shiue L, Zhu
H, Cambi F, Kasarskis E, Ares M Jr, Burge CB, Rigo F, Yeo GW. In Press Nature Communications
2016.
John Timothy Greenamyre, MD, PhD – Professor
Tyurina YY, Polimova AM, Maciel E, Tyurin VA, Kapralova VI, Winnica DE, Vikulina A,
Domingues RM, Sanders LH, Bayir H, Greenamyre JT, Kagan VE, LC/MS analysis of cardiolipins
in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in
Parkinson’s disease, Free Rad Res 5:1-11, 2015. PMC4430340
Zharikov A, Cannon JR, Tapias V, Bai Q, Horowitz M, Shah V, El Ayadi A, Hastings TG,
Greenamyre JT, Burton EA, shRNA targeting α-synuclein prevents neurodegeneration in a
Parkinson’s disease model, J Clin Invest 125:2721-35, 2015. PMC4563670
Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT,
Burton EA, Hastings TG, Greenamyre JT. α-Synuclein binds to TOM20 and inhibits mitochondrial
protein import in Parkinson's disease. Sci Transl Med 2016;8:342ra78. PMC5016095
Huntington Study Group PI, Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman
MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, Siemers E,
Tanner C, Mallonee W, Suter G, Dubinsky R, Gray C, Nance M, Bundlie S, Radtke D, Kostyk S,
Baic C, Caress J, Walker F, Hunt V, O'Neill C, Chouinard S, Factor S, Greenamyre T et al. Clinical-
Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS):
Implications for Clinical Trials. JAMA Neurology 73:102-10, 2016.
Sahoo B, Arduini I, Drombosky KW, Kodali R, Sanders LH, Greenamyre JT, Wetzel R. Folding
Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No
Detectable Monomer. PLoS One. 2016;11:e0155747. PMC4894636
185
Houman Homayoun, MD, Assistant Professor
Homayoun, H (2016) Movement Disorders and Neuromuscular Disorders sections. In MKSAP17
Neurology, American Academy of Physicians,.
Neurocritical Care
Bradley Molyneaux, M.D., PhD, Assistant Professor
Aghaebrahim, A., Jadhav, A.P., Saeed, Y, Totoraitis, R., Jankowitz, B.T., Jovin, T., and Molyneaux,
Molyneaux, B.J.*, Goff, L.A.*, Brettler, A.C., Chen, H.H., Hrvatin, S., Rinn, J.L., and Arlotta, P. 2015.
DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection
in neocortex. Neuron. 85:275-288. (with video abstract)
Callaway, C.W., Elmer, J., Guyette, F.X., Molyneaux, B.J., Anderson, K.B., Empey, P.E., Gerstel, S.J.,
Holquist, K., Repine, M.J., and Rittenberger, J.C. (2015). Dexmedetomidine Reduces Shivering during
Mild Hypothermia in Waking Subjects. PLoS ONE 10, e0129709.
Ruchira Menka Jha, MD, Clinical Instructor
Chrenek R, Magnotti LM, Herrera GR, Jha RM, Cardozo DL. Characteriation of the filum terminale as
a neural progenitor cell niche in both rats and humans. J Comp Neurol: August 2016 (Epub ahead of print).
Topcuoglu MA, Jha RM, George J, Frosch MP, Singhal AB. Hemorrhagic Primary CNS Angiitis and
Vasoconstrictive Drug Exposure. Neurology: Clinical Practice, in press.
Jha RM, Puccio A, Chou S, Chang CCH, Wallisch J, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac
SM, Janesko-Feldman K, Okonkwo DO, Kochanek PM. Sulfonylurea receptor 1 is a potential biomarker
for cerebral edema in traumatic brain injury. Critical Care Medicine, in press.
Jha RM, Puccio A, Okonkwo DO, Zusman BE, Park S-Y, Wallisch J, Empey PE, Shutter LA, Clark RSB,
Kochanek PM, Conley YP. ABCC8 Single nucleotide polymorphisms are associated with cerebral edema
in severe TBI. Neurocritical Care, in press.
Lori Shutter, MD, Professor
Jackson J, Wilmarth M, Shutter L. Update of Clinical Practice Guidelines for Brain Death Determination
in an Academic Heath Center. J Neurosci Nurs 2015;47:44-50. doi: 10.1097/JNN.0000000000000110.
PMID: 25565594
Muehlschlegel S, Shutter L, Col N, Goldberg R. Decision Aids and Shared Decision-Making in
Neurocritical Care: An Unmet Need in Our NeuroICUs. Neurocrit Care. 2015 Jan 6. [Epub ahead of print]
Mirzaalian, H, Ning L, Savadjiev P, Pasternak O, Bouix S, Michailovich O, Grant G, Marx CE, Morey
RA, Flashman LA, George MS, McAllister TW, Andaluz N, Shutter L, Coimbra R, Zafonte RD, Coleman
MJ, Kubicki M, Westin CF, Stein MB, Shenton ME, Rathi Y. Inter-site and inter-scanner diffusion MRI
data harmonization. NeuroImage 2016; 135:311–323. doi: 10.1016/j.neuroimage.2016.04.041. Epub 2016
Apr 30. PMID: 27138209.
186
Elmer J, Gianakas JJ, Rittenberger JC, Baldwin ME, Faro J, Plummer C, Shutter LA, Wassel CL,
Callaway CW, Fabio A; Pittsburgh Post-Cardiac Arrest Service. Group-Based Trajectory Modeling of
Suppression Ratio After Cardiac Arrest. Neurocrit Care 2016;25:415-423. PMID: 27033709
Dreier J, Fabricius, M, Ayata, C, Sakowitz, O, et al. Recording, analysis, and interpretation of spreading
depolarizations in neurointensive care: review and recommendations of the COSBID research group. J
Cereb Blood Flow Metab. 2016 Jun 17. pii: 0271678X16654496. doi: 10.1177/0271678X16654496.
[Epub ahead of print] PMID: 27317657
Coppler PJ, Marill KA, Okonkwo DO, Shutter LA, Dezfulian C, Rittenberger JC, Callaway CW, Elmer
J. Concordance of Brain and Core Temperature in Comatose Patients After Cardiac Arrest. Ther
Hypothermia Temp Manag 2016;6:194-197. [Epub 2016 Jun 1]. PMID: 27249337
Jha RM, Puccio AM, Okonkwo DO, Zusman BE, Park SY, Wallisch J, Empey PE, Shutter LA, Clark
RS, Kochanek PM, Conley YP. ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral
Edema in Severe TBI. Neurocrit Care 2017;26(2):213-224. doi: 10.1007/s12028-016-0309-z [Epub 2016
Sep 27]. PMID: 27677908
Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA,
Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Sulfonylurea Receptor-1: A Novel
Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Crit Care Med 2017;45(3):e255-e264.
doi: 10.1097/CCM.0000000000002079 [Epub 2016 Nov 14]. PMID: 27845954
Mirzaalian H, Ning L, Savadjiev P, Pasternak O, Bouix S, Michailovich O, Karmacharya S, Grant G,
Marx CE, Morey RA, Flashman LA, George MS, McAllister TW, Andaluz N, Shutter L, Coimbra R,
Zafonte RD, Coleman MJ, Kubicki M, Westin CF, Stein MB, Shenton ME, Rathi Y. Multi-site
harmonization of diffusion MRI data in a registration framework. Brain Imaging Behav. 2017 Feb 7. doi:
10.1007/s11682-016-9670-y. [Epub ahead of print] PMID: 28176263
Neuroimmunology Division
Zongqi Xia, MD, PhD
Liao K, Cai T, Savova G, Murphy S, Karlson E, Ananthakrishnan A, Gainer S, Shaw S, Xia Z, Szolovits
P, Churchill S, and Kohane I (2015). Development of phenotype algorithms using electronic medical
records and incorporating natural language processing. BMJ. 350: h1885. PMCID: PMC4707569.
Liao K, Ananthakrishnan A, Kumar V, Xia Z, Cagan A, Gainer V, Goryachev S, Chen P, SavovaG,
Agiel D, Churchill S, Lee J, Murphy S, Plenge, R, Szolovits P, Kohane I, Shaw S, Karlson E and Cai T
(2015). Methods to develop an electronic medical record phenotype algorithm to compare the risk of
coronary artery disease across 3 chronic disease cohorts. PLoS One. 10(8):e0136651. PMCID:
PMC4547801.
Xia Z, White C, Owen E, von Korff A, Clarkson S, McCabe C, Cimpean M, Winn P, Hoesing A, Steele
S, Cortese I, Chitnis T, Weiner H, Reich D, Chibnik L and De Jager P (2015). Genes and Environment
in Multiple Sclerosis (GEMS) Project: a platform to investigate multiple sclerosis risk. Annals of Neurology. 79: 178-89. PMCID: PMC4778957.
Bove R, Musallam A, Xia Z, Baruch N, Messina S, Healy B and Chitnis T (2016). Longitudinal BMI
trajectories in multiple sclerosis: sex differences in association with disease severity. Multiple Sclerosis and Related Disorders. ePublished.
Bove R, Chua A, Xia Z, Chibnik L, De Jager P and Chitnis T (2016). Complex relation of HLA
DRB1*1501, age at menarche and age at multiple sclerosis onset. Neurology Genetics. 2: e88. PMCID:
PMC4962522.
187
Bargiela D, Bianchi M, Westover B, Chibnik L, Healy B, De Jager P and Xia Z (2017). Selection of
first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 88: 677-684.
PMCID: PMC5317380.
Xia Z, Steele S, Bakshi A, Clarkson S, White C, Schindler M, Dewey B, Price L, Nair G, Ohayon J,
Chibnik L, Cortese I, De Jager P and Reich D (2017). Assessment of early evidence of multiple sclerosis
in a prospective study of asymptomatic high-risk first-degree family members. JAMA Neurology. 74:
293-300. PMCID: PMC5348267.
Xia Z and Friedlander R (2017). Minocycline in multiple sclerosis: compelling results but too early to
tell. N Engl J Med. 376: 2191-2193.
Neuromuscular Diseases Division
David Lacomis, MD, Professor and Chief, Neuromuscular Diseases
Avila D, Lacomis D. Neuromuscular Pathology Case. J Clin Neuromusc Dis 2015;17:30-33.
PMID:2630137.
El-Dokla A, Lacomis D. Histopathologic Findings in Five Patients with Hypomyopathic
Dermatomyositis: The importance of MHC 1 expression on myofibers. J Clin Neuromusc Dis 2015;
17:52-58 PMID:26583490.
Juranek JK, Daffu GK, Wojkiewiz J, Lacomis D, Kofler J, Schmidt AA. Receptor for advanced glycation
end products and its inflammatory ligands are upregulated in amyotrophic lateral sclerosis. Front Cell Neurosci, 22 December 2015 http://dx.doi.org/10.3389/fncel.2015.00485.
Shefner JM, Wolff AA, Meng L, Bian A, Lee J, Barragan D, Andrews JA & On behalf of the Benefit-
ALS study group: A randomized, placebo-controlled, double –blind phase IIB trial evaluating the safety
and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis, Amyotroph Lateral Scler
Frontotemporal Degener. 2016;1-10 PMID:26982815.
Avila JD, Lacomis D, Lam E. Neuralgic Amyothophy Associated with hepatitis E virus infection: First
case in the United States: J Clin Neuromusc Dis, in press.
Galdys A, Kale H, Lacomis D, Vergidis P, Murdoch G. Progressive right-sided hemiparesis in a man
with sarcoidosis. Clin Infect Dis 2016;9:1186-1187 PMID:27060792.
Avila JD, Lacomis D. Proximal limb weakness in a patient with celeiac disease; Copper deficiency, gluten
sensitivity or both underlying cause? Case Reports in Neurological Medicine 2016;54:1594-9. PMIC
27994896.
Gendrom TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity
LM, Jansen-West K, Perkerson EA, O’Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian
LJ, Lee CW, ue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW,
Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A,
Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN,
McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A,
Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitchevea D, Antognetti G,
McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski
188
JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD,
Floeter MK, Rothstein JD, Boylan KB, Petrucelli L. Poly(GP) proteins are a useful pharmacodynamic
marker for C90RF72-associated amyotrophic lateral sclerosis. Sci Transl Med. 2017 Mar 29:9(383).
Pii:eaai7866. Doi;10.1126/scitranslmed.aai7866.MPIC 28356511.
Araya Puwananat, MD, Assistant Professor
Heatwole C, Bode R, Johnson N, Dekdebrun J, Dilek N, Eichinger K, Hilbert JE, Logigian E, Luebbe E,
Martens W, McDermott, MP, Pandya S, Puwanant A, Rothrock N, Thornton C, Vickrey BG, Victorson
D, Moxley RT. The myotonic dystrophy health index: Correlations with clinical tests and patient function.
Muscle Nerve 2015; June 4. doi:10.1002/mus.24725. [Epub ahead of print]. PMID 26044513.
Saša Živković, MD, PhD Associate Professor
Silvestri NJ, Zivkovic S, Wolfe GI, Lacomis D. What’s in the Literature: Journal of Clinical
Neuromuscular Disease. 2015 Mar; 16 (3)170-9. PMID: 25695923. Doi:
10.1097/CND.0000000000000073.
Zivokic S, Intravenous immunoglobulin in the treatment of neurologic disorders. Acta Neurologica Scandinavica. 2015 May 21. PMID: 25997034. Doi: 10.1111/ane.12444.
Avila JD, Živkovic S. The neurology of solid organ transplantation. Current Neurology and Neuroscience
Reports. 2015 Jul; 15 (7):560. PMID: 26008808. doi: 10.1007/s11910-015-0560-2.
Felicetti P, Trotta F, Bonetto C, Santuccio C, Pernus YB, Burgner D, Chandler R, Girolomoni G, Hadden
RD, Kochar S, Kukucu M, Monaco G, Ozen S, Pahud B, Phuong L, Bachtiar NS, Teeba A, Top K,
Varricchio F, Wise RP, Zanoni G, Živkovic S, Bonhoeffer J, Brighton Collaboration Vasculitis Working
Group. Spontaneous reports of vasculitis as an adverse event following immunization: A descriptive
analysis across three international databases. Vaccine. 2015 Sep 18. PMID: 26392009. doi:
10.1016/j.vaccine.2015.09.027.
Bonetto C, Trotta F, Felicetti P, Santuccio C, Bachtiar NS, Pernus YB, Chandler R, Girolomoni G, Hadden
RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živkovic S, Bonhoeffer J,
Brighton Collaboration Vasculitis Working Group. Vasculitis as an adverse event following immunization
- Systematic literature review. Vaccine. 2015 Sep 19. PMID: 26398442. doi:
10.1016/j.vaccine.2015.09.026.
Avila JD, Živkovic S. Spinal epidural abscess following treatment with rituximab. Acta Neurologica
Scandinavica. 2015 Sep 22. PMID: 26392320. doi: 10.1111/ane.12506.
Hadden RD, Collins MP, Živkovic SA, Hsieh ST, Bonetto C, Felicetti P, Marchione P, Santuccio C,
Bonhoeffer J, Brighton Collaboration Vasculitic Peripheral Neuropathy Working Group. Vasculitic
peripheral neuropathy: Case definition and guidelines for collection, analysis, and presentation of
immunisation safety data. Vaccine. 2015 Dec 2. PMID: 26655629. doi: 10.1016/j.vaccine.2015.11.047.
Lange-Maia BS, Newman AB, Cauley JA, Boudreau RM, Jakicic JM, Caserotti P, Glynn NW, Harris TB,
Kritchevsky SB, Schwartz AV, Satterfield S, Simonsick EM, Vinik AI, Zivkovic S, Strotmeyer ES, Health,
Aging and Body Composition Study. Sensorimotor Peripheral Nerve Function and the Longitudinal
Relationship With Endurance Walking in the Health, Aging and Body Composition Study.
Archives of Physical Medicine and Rehabilitation. 2016 Jan; 97 (1):45-52. PMCID: PMC4696894. PMID:
26343170. doi: 10.1016/j.apmr.2015.08.423.
189
Lange-Maia BS, Cauley JA, Newman AB, Boudreau RM, Jakicic JM, Glynn NW, Zivkovic S, Dam T,
Caserotti P, Cawthon PM, Orwoll ES, Strotmeyer ES. Sensorimotor Peripheral Nerve Function and
Physical Activity in Older Men. Journal of Aging and Physical Activity. 2016 Mar 11. PMID: 26964668.
doi:10.1123/japa.2015-0207.
Hersh AO, Alarcón GS, Bonetto C, Pernus YB, Kucuku M, Santuccio C, Živković S, Bonhoeffer J;
Brighton Collaboration Systemic Lupus Erythematosus Working Group.Systemic Lupus Erythematosus:
Case definition and guidelines for data collection,analysis, and presentation of immunization safety data.
Vaccine. 2016 Dec 12;34(51):6572-81. doi: 10.1016/j.vaccine.2016.09.031. PubMed PMID: 27816371.
Mnatsakanova D, Živković S. Iatrogenic amyloid polyneuropathy after domino liver transplantation. World J Hepatol. 2017 Jan 28; 9(3):126-30. doi:10.4254 /wjh.v9.i3.126. PubMed PMID: 28217248.
Gonzalez N, Puwanant A, Lu A, Marks S, Živković SA. Myasthenia triggered by immune checkpoint
inhibitors: new case and literature review. 2017 Mar; 27 (3):266-8. doi: 10.1016/j.nmd.2017.01.002.
PubMed PMID: 28109638.
Jacobs BC, van den Berg N, Verboon C, Chavada G, Cornblath DR, Gorson KC, Harbo T, Hartung HP,
Hughes RA, Kusunoki S, van Doorn, PA, Willison HJ, IGOS Consortium. International Guillain-Barré
Syndrome Outcome Study (IGOS):Protocol of a prospective observational cohort study on clinical and
biological predictors of disease course and outcome in Guillain-Barré. J Periph Nerv Syst.
doi:10.1111/jms.12209. PMID: 28406555.
Lange-Maia BS, Newman AB, Jakicic JM, Cauley JA, Boudreau RM, Schwartz AV, Simonsick EM,
Satterfield S, Vinik AI, Zivkovic S, Harris TB, Strotmeyer ES. Relationship between sensorimotor
peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the
Health, Aging and Body Composition Study. Exp Gerontol. 2017 Apr 22. pii: S0531-5565(16)30201-7.
doi:10.1016/j.exger.2017.04.007. [Epub ahead of print] PubMed PMID.
Neurooncology Program
Jan Drappatz, MD, Associate Professor
Kaley TJ, Wen P, Schiff D, Ligon K, Haidar S, Karimi S, Lassman AB, Nolan CP, DeAngelis LM,
Gavrilovic I, Norden A, Drappatz J, Lee EQ, Purow B, Plotkin SR, Batchelor T, Abrey LE, Omuro A.
Phase II trial of sunitinib for recurrent and progressive atypical and anaplastic meningioma. Neuro Oncol.
2015 Jan;17(1):116-21. Epub 2014 Aug 6. PMID: 25100872.
Lee EQ, Reardon DA, Schiff D, Drappatz J, Muzikansky A, Grimm SA, Norden AD, Nayak L,
Beroukhim R, Rinne ML, Chi AS, Batchelor TT, Hempfling K, McCluskey C, Smith KH, Gaffey SC,
Wrigley B, Ligon KL, Raizer JJ, Wen PY. Phase II study of panobinostat in combination with
bevacizumab for recurrent glioblastoma and anaplastic glioma. Neuro Oncol. 2015 Jan 7. pii: nou350.
[Epub ahead of print]. PMID: 25572329.
Norden AD, Ligon KL, Hammond SN, Muzikansky A, Reardon DA, Kaley TJ, Batchelor TT, Plotkin SR,
Raizer JJ, Wong ET, Drappatz J, Lesser GJ, Haidar S, Beroukhim R, Lee EQ, Doherty L, Lafrankie D,
Gaffey SC, Gerard M, Smith KH, McCluskey C, Phuphanich S, Wen PY. Phase II study of monthly
pasireotide LAR (SOM230C) for recurrent or progressive meningioma. Neurology. 2015 Jan
20;84(3):280-6. Epub 2014 Dec 19. PMID: 25527270. PMCID: 4335993.
190
Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden
AD, Gerstner ER, Betensky RA, Batchelor TT. Vandetanib plus sirolimus in adults with recurrent
glioblastoma: results of a phase I and dose expansion cohort study. J Neurooncol. 2015 Feb;121(3):627-
34. Epub 2014 Dec 13. PMID: 25503302. PMCID: 4324090.
Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow B, Muzikansky A,
Ancukiewicz M, Huse JT, Ramkissoon SH, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander
BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor T, Ligon KL, Wen PY. A multicenter,
phase II, randomized, non-comparative clinical trial of radiation and temozolomide with or without
vandetanib in newly-diagnosed glioblastoma patients. Clin Cancer Res. 2015 Apr 24. pii:
clincanres.3220.2014. [Epub ahead of print]. PMID: 25910950.
Lee EQ, Reardon DA, Schiff D, Drappatz J, Muzikansky A, Grimm SA, Norden AD, Nayak L,
Beroukhim R, Rinne ML, Chi AS, Batchelor TT, Hempfling K, McCluskey C, Smith KH, Gaffey SC,
Wrigley B, Ligon KL, Raizer JJ, Wen PY. Phase II study of panobinostat in combination with
bevacizumab for recurrent glioblastoma and anaplastic glioma. Neuro Oncol. 2015 Jun;17(6):862-7. Epub
2015 Jan 7. PMID: 25572329.
Nikiforova MN, Wald AI, Melan MA, Roy S, Zhong S, Hamilton RL, Lieberman FS, Drappatz J,
Amankulor NM, Pollack IF, Nikiforov YE, Horbinski C. Targeted next-generation sequencing panel
(GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol. 2015
Dec 17. pii: nov289. [Epub ahead of print]. PMID: 26681766.
McDowell MM, Zhu X, Agarwal N, Nikiforova MN, Lieberman FS, Drappatz J. Response of relapsed
central nervous system hairy cell leukemia to vemurafenib. Leuk Lymphoma. 2016 Apr 27:1-3. [Epub
ahead of print] No abstract available. PMID: 27116997.
Lee EQ, Muzikansky A, Drappatz J, Kesari S, Wong ET, Fadul CE, Reardon DA, Norden AD, Nayak
L, Rinne ML, Alexander BM, Arvold ND, Doherty L, Stefanik J, LaFrankie D, Ruland SF, Pulverenti J,
Smith KH, Gaffey SC, Hammond S, Wen PY. A randomized, placebo-controlled pilot trial of armodafinil
for fatigue in patients with gliomas undergoing radiotherapy. Neuro Oncol. 2016 Jun;18(6):849-54. doi:
10.1093/neuonc/now007. Epub 2016 Feb 21. PMID: 26902850.
Boele FW, Given CW, Given BA, Donovan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS,
Sherwood PR. Family caregivers' level of mastery predicts survival of patients with glioblastoma: A
preliminary report. Cancer. 2016 Oct 27. [Epub ahead of print] PMID: 27787881.
Lieberman, MD, Professor
Robins HI, Zhang P, Gilbert MR, Chakravarti A, de Groot JF, Grimm SA, Wang F, Lieberman FS,
Krauze A, Trotti AM, Mohile N, Kee AY, Colman H, Cavaliere R, Kesari S, Chmura SJ, Mehta M. A
randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide
resistant glioblastoma: an NRG oncology RTOG group study. J Neurooncol. 2016 Jan;126(2):309-16.
Epub 2015 Oct 27. PMID: 26508094.
Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, Taylor LP, Lieberman F, Silvani
A, Fink KL, Barnett GH, Zhu JJ, Henson JW, Engelhard HH, Chen TC, Tran DD, Sroubek J, Tran ND,
Hottinger AF, Landolfi J, Desai R, Caroli M, Kew Y, Honnorat J, Idbaih A, Kirson ED, Weinberg U, Palti
Y, Hegi ME, Ram Z. Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs
Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. JAMA. 2015 Dec 15;314(23):2535-
43. PMID: 26670971.
191
Nikiforova MN, Wald AI, Melan MA, Roy S, Zhong S, Hamilton RL, Lieberman FS, Drappatz J,
Amankulor NM, Pollack IF, Nikiforov YE, Horbinski C. Targeted next-generation sequencing panel
(GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol. 2016
Mar;18(3):379-87. Epub 2015 Dec 17. PMID: 26681766.
McDowell MM, Zhu X, Agarwal N, Nikiforova MN, Lieberman FS, Drappatz J. Response of relapsed
central nervous system hairy cell leukemia to vemurafenib. Leuk Lymphoma. 2016 Apr 27:1-3. [Epub
ahead of print] No abstract available. PMID: 27116997.
Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM,
Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C,
Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen MC, Van Meir EG, Osuka S,
Fan X, Muraszko KM, Tirapelli DP, Oba-Shinjo SM, Marie SK, Carlotti CG, Lee JY, Nageswara Rao
AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S,
Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM,
Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M,
Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach
A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T,
Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG,
Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F,
Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U,
Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR,
Armstrong TS, Korshunov A, Ellison DW, Taylor MD. Therapeutic Impact of Cytoreductive Surgery and
Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
J Clin Oncol. 2016 Jun 6. pii: JCO657825. [Epub ahead of print] PMID: 27269943.
Yankeelov TE, Mankoff DA, Schwartz LH, Lieberman FS, Buatti JM, Mountz JM, Erickson BJ, Fennessy
FM, Haung W, Kalpathy-Cramer J, Wahl RL, Linden HM, Kinahan PE, Zhao B, Hylton NM, Gillies RJ,
Clarke L, Nordstom R, Rubin DL. Quantitative Imaging in Cancer Clinical Trials. Clin Cancer Res. 2016
Jan 15;22(2):284-90. Review. PMID: 26773162.
Lodge MA, Holdhoff M, Leal JP, Bag AK, Nabors LB, Mintz A, Lesser GJ, Mankoff DA, Desai AS,
Mountz JM, Lieberman FS, fisher JD, Desideri S, Ye X, Grossman SA, Schiff D, Wahl RL. Repatability
of 18F-FLT-PET in a Multi-Center Study of Patients with High Grade Glioma. J Nuci Med. 2016 Sep 29.
Pii: jnumed.116.178434. [Epub ahead of print] PMID: 276688473.
Boele FW, Given CW, Given BA, Donavan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS,
Sherwood PR. Family caregivers’ level of mastery predicts survival of patients with glioblastoma:A
preliminary report. Cancer. 2016 Oct 27. [Epub ahead of print] PMID: 27787881.
Research Division
Franca Cambi, MD, PhD, Professor
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz
K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ,
Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey
RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo
192
ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS,
Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills
AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a
randomized clinical trial. JAMA. 2015 Feb 10;313(6):584-93. doi: 10.1001/jama.2015.120.
GM1 ganglioside in Parkinson’sdisease: Pilot study of effects on dopamine transporter binding. Schneider
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Jiang X, Pu H, Hu X, Wei Z, Hong D, Zhang W, Gao Y, Chen J, Shi Y. A Post-stroke Therapeutic
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Paula Clemens, MD, Professor and Chief of Service, VAMC
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Eric Hoffman, PhD, Research Assistant Professor
Di Maio R, Barrett PJ, Hoffman EK, Barrett C, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton
EA, Hastings TG, Greenamyre JT. α-Synuclein binds TOM20 and inhibits mitochondrial protein import
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Xiaoming Hu, MD, MS, PhD, Research Assistant Professor
Zhang W, Liu J, Hu X, Li P, Leak RK, Gao Y, Chen J. N-3 polyunsaturated fatty acids reduce neonatal
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Liu ZJ, Chen C, Li XR, Ran YY, Xu T, Zhang Y, Geng XK, Zhang Y, Du HS, Leak RK, Ji XM, Hu X#.
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Zhang W, Zhang H, Mu H, Zhu W, Jiang X, Hu X, Shi Y, Leak RK, Dong Q, Chen J, Gao Y. Omega-3
polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury.
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Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji
X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and
long-term ischaemic reperfusion brain injury. Nat Commun. 2016; 27;7:10523. Citation: 12
Liu X, Liu J, Zhao S, Zhang H, Cai W, Cai M, Ji X. Leak KL, Gao Y, Chen J, Hu X#. Interleukin-4 is
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An C, Jiang X, Pu H, Hong D, Zhang W, Hu X, Gao Y. Severity-dependent long-term spatial learning-
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Jiang X, Pu H, Hu X, Wei Z, Hong D, Zhang W, Gao Y, Chen J, Shi Y. (2016) A post-stroke therapeutic
regimen with omega-3 polyunsaturated fatty acids that promotes white matter integrity and beneficial
microglial responses after cerebral ischemia. Transl Stroke Res. 7(6):548-561.
Pu H, Jiang X, Hu X, Xia J, Hong D, Zhang W, Gao Y, Chen J, Shi Y. Delayed docosahexaenoic acid
treatment combined with dietary supplementation of omega-3 fatty acids promotes long-Term
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Cai W, Liu H, Zhao J, Chen LY, Chen J, Lu Z, Hu X#. Pericytes in brain injury and repair after ischemic
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Liu H, Yang Y, Xia Y, Zhu W, Leak RK, Wei Z, Wang J, Hu X#. Aging of cerebral white matter. Ageing
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Cai W, Zhang K, Li P, Zhu L, Xu J, Yang B, Hu X, Lu Z, Chen J. Dysfunction of the neurovascular unit
in ischemic stroke and neurodegenerative diseases: An aging effect. Ageing Res Rev. 2017;34:77-87
Shi Y, Jiang X, Zhang L, Pu H, Hu X, Zhang W, Cai W, Gao Y, Leak RK, Keep RF, Bennett MV, Chen
J. Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier
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Hu X, De Silva TM, Chen J, Faraci FM. Cerebral vascular disease and neurovascular injury in ischemic
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Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen
G, Hu X#. Regulatory T cells ameliorate tissue plasminogen activator-induced brain hemorrhage after
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198
Milos Ikonomovic, MD, Associate Professor
Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ (2015)
Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal
Alzheimer’s disease Biol Psych 77(8):693-703.
Pivtoraiko VN, Abrahamson EE, Leurgans SE, DeKosky ST, Mufson EJ, Ikonomovic MD (2015)
Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease. Neurobiol Aging
36(1):12-19.
Scheff SW, Price DA, Ansari MA, Roberts KN, Schmitt FA, Ikonomovic MD, Mufson EJ (2015)
Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease. J Alzheimers
Dis 2015;43:1073-1090.
Curtis C, Gamez JE, Singh U, Sadowsky CH, Villena T, Sabbagh MN, Beach TG, Duara R, Fleisher AS,
Frey KA, Walker Z, Hunjan A, Holmes C, Escovar YM, Vera CX, Agronin ME, Ross J, Bozoki A,
Akinola M, Shi J, Vandenberghe R, Ikonomovic MD, Sherwin PF, Grachev ID, Farrar G, Smith APL,
Buckley CJ, McLain R, Salloway S (2015) Phase 3 trial of flutemetamol labeled with radioactive fluorine
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Perez SE, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ (2015) Hippocampal
endosomal, lysosomal and autophagic dysregulation in mild cognitive impairment: correlation with Aβ
and tau pathology. J Neuropathol Exp Neurol 74(4):345-358.
Jackson TC, Bayir H, Ikonomovic MD, Janesko-Feldman K, Mi Z, Gao T, Jackson EK, Kochanek PM
(2015) Detection of PHLPP1α/β in human and mouse brain by different anti-PHLPP1 antibodies. Sci Rep. 5:9377. doi: 10.1038/srep09377. PMID: 25827478
Mufson EJ, Mahady L, Waters D, Counts S, DeKosky ST, Ginsberg SD, Ikonomovic MD, Perez SE,
Scheff S (2015) Hippocampal plasticity during the progression of Alzheimer's disease. Neuroscience 2015
Nov 19;309:51-67.
Marquie M, Normandin MD, Vanderburg CR, Costantino I, Bien EA, Rycyna LG, Klunk WE, Mathis
CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA,
Frosch MP, Hyman BT, Gomez-Isla T (2015) Validating novel tau PET tracer [F-18]-AV-1451 (T807)
on postmortem brain tissue. Ann Neurol 2015 Nov78(5):787-800.
Willyeard FA, Empey PE, Philbrick A, Ikonomovic MD, Puccio AM, Kochanek PM, Okonkwo DO,
Clark RSB (2016) Expression of ATP-binding cassette transporters B1 and C1 after severe traumatic brain
injury in humans. J Neurotrauma 33:226-231.
Kelley CM, Ash JA, Powers BE, Velazquezc R, Alldred MJ, Ikonomovic MD, Ginsberg SD, Strupp BJ,
Mufson EJ (2016) Effects of maternal choline supplementation on the septohippocampal cholinergic
system in the Ts65Dn mouse model of Down syndrome. Curr Alzheimer Res 13:84-96.
Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD (2016) Immunohistochemical analysis
of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.
Neuropathology 36:135-145.
199
Kirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun
M, Kofler JK, Lopez OL, Yates NA, Sweet RA (2016) Altered Levels of Visinin-Like Protein 1
Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 75(2):175-182.
Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic
MD, Lopez OL, Fitz NF, Koldamova R, Yates NA (2016) APOE*4 genotype is associated with altered
levels of glutamate signaling proteins and synaptic co-expression networks in the prefrontal cortex in mild
to moderate Alzheimer disease. Mol Cell Proteomics 15(7):2252-2262.
Ikonomovic MD, Abrahamson EE, Price J, Mathis CA, Klunk WE (2016) [F-18]AV-1451 PET retention
in choroid plexus: more than “off-target” binding. Ann Neurology 80(2):307-308.
Mufson EJ, Ikonomovic MD, Counts SE, Perez SE, Malek-Ahmadi M, Scheff SW, Ginsberg SD (2016)
Molecular and cellular pathophysiology of preclinical Alzheimer’s disease. Behav Brain Res 311:54-69.
Mi Z, Halfter W, Abrahamson EE, Klunk WE, Mathis CA, Mufson EJ, Ikonomovic MD (2016).
Tenascin-C is associated with cored amyloid-β plaques in Alzheimer’s disease and pathology burdened
cognitively normal elderly. J Neuropathol Exp Neurol 75(9):868-876.
Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford
F, Alvarez V, Stein T, McKee AC (2016) Progression of tau pathology within cholinergic nucleus basalis
neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain
Inj. 30(12):1399-1413.
Ikonomovic MD, Buckley CJ, Heurling K, Sherwin P, Jones PA, Zanette M, Mathis CA, Klunk WE,
Chakrabarty A, Ironside J, Ismail A, Smith C, Thal DR, Beach TG, Farrar G, Smith AP (2016) Post-
mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection. Acta
Neuropathol Commun. 12;4(1):130-155.
Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk
WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S,
DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch
MP, Hyman BT, Johnson KA, Gómez-Isla T (2017) Pathological correlations of [F-18]-AV-1451 imaging
in non-Alzheimer tauopathies. Ann Neurol. 81(1):117-128.
Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA (2017)
Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic
mice. Neurobiol Aging. 54:59-70.
Mi Z, Abrahamson EE, Ryu AY, Fish KN, Sweet RA, Mufson EJ, Ikonomovic MD (2017) Loss of
precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early
Alzheimer's disease. Neurobiol Aging. 2017. doi: 10.1016/j.neurobiolaging.2017.01.022. [Epub ahead of
print]
Hao Liu, PhD, Research Assistant Professor
Liu H, Li W, Rose ME, Hickey RW, Chen J, Uechi GT, Balasubramani M, Day B, Patel K, Graham SH.
The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-
induced cytotoxicity: implications for post-ischemic neuronal injury. Cell Death Dis. 2015. 6: e1966;
doi:10.1038/cddis.2015.323
200
Chen Y, Huang XJ, Yu N, Xie Y, Zhang K, Wen F, Liu H, Di Q. HMGB1 Contributes to the Expression
of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced
Glycation End Products. PLoS One. 2015 Oct 20;10(10):e0140918
Liu H, Chen J, Li W, Rose ME, Shinde SN, Balasubramani M, Uechi GT, Mutus B, Graham SH, Hickey
RW. Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for
hypoxic ischemic injury. FEBS J. 2015 May;282(10):2045-59. doi: 10.1111/febs.13259.
Graham SH, Liu H. Life and death in the trash heap: the ubiquitin proteasome pathway and UCHL1 in
brain aging, neurodegenerative disease and cerebral ischemia. Ageing Research Reviews. 2016 Oct 1.
pii: S1568-1637(16)30172-6. doi: 10.1016/j.arr.2016.09.011.
Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH. Rosiglitazone attenuates inflammation and
CA3 neuronal loss following traumatic brain injury in rats. Biochem Biophys Res Commun. 2016 Apr
15;472(4):648-55. doi: 10.1016/j.bbrc.2016.03.003. Epub 2016 Mar 3.
Liu H, Rose ME, Ma X, Culver S, Dixon CE, Graham SH. In vivo transduction of neurons with TAT-
UCH-L1 protects brain against controlled cortical impact injury. PLoS One. 2017 May
24;12(5):e0178049. doi: 10.1371/journal.pone.0178049.
Ruth Stetler, PhD, Research Assistant Professor
Suenaga J, Hu X, Pu H, Shi Y, Hassan SH, Xu M, Leak RK, Stetler RA, Gao Y, Chen J. White matter
injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in
neurological function after stroke. Exp Neurol, 2015;272:109-119.
Leak RK, Li P, Zhang F, Hassan SH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y, Chen J. APE1
upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury.
Antioxidants & Redox Signaling, 2015;22(2);135-148.
Sun BL, He MQ, Han XY, Sun Jy, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,
Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal delivery of granulocyte colony-
stimulating factor enhances its neuroprotective effects against ischemic brain injury in rats. Mol
Neurobiol. 2016;53:320-330.
Shi Y, Zhang L, Pu H, Mao L, Hu X, Jian X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji
X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and
long-term ischaemic reperfusion brain injury. Nat Comm. 2016;7. doi:10.1038/ncomms10523.
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,
Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter
and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567,
doi:10.1073/pnas1606226113.
Sun BL, He MQ, Han XY, Sun Jy, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,
Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal delivery of granulocyte colony-
stimulating factor enhances its neuroprotective effects against ischemic brain injury in rats. Mol
Neurobiol. 2016;53:320-330.
201
Shi Y, Zhang L, Pu H, Mao L, Hu X, Jian X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji
X, Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and
long-term ischaemic reperfusion brain injury. Nat Comm. 2016;7. doi:10.1038/ncomms10523
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,
Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref1 facilitates recovery of gray and white matter
and neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016;E3558-E3567,
doi:10.1073/pnas1606226113.
Li PY, Wang X, Stetler RA, Chen J, Yu WF. Anti-inflammatory signaling: the point of convergence for
medical gases in neuroprotection against ischemic stroke. Med Gas Res. 2016 Dec 30;6(4):227-231.
Zhang W, Chen R, Yang T, Xu N, Chen J, Gao Y, Stetler RA. Fatty acid transporting proteins : Roles
in brain development, aging, and stroke. Prostaglandins, Leukot and Essent Fatty Acids. 2017;
doiI:10.1016/j.plefa.2017.04.004.
Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan S, Stetler RA, Chen J. MicroRNA-15a/16-1 antagomir
ameliorates ischemic brain injury in experimental stroke. Stroke. 2017:in press.
Mao L, Li P, Zhu W, Cai W, Liu Z, Wang Y, Luo W, Stetler RA, Leak RK, Yu W, Gao Y, Chen J, Chen
G, Hu X. Regulatory T cells ameliorate tissue plasminogen activator-induced brain hemorrhage after
stroke. Brain. 2017:in press.
Zhang J, Pu H, Zhang H, Wei Z, Jiang X, Xu M, Zhang L, Zhang W, Liu J, Meng H, Stetler RA, Sun
D, Chen J, Gao Y, Chen L. Inhibition of Na+-K+-2Cl− cotransporter attenuates blood-brain-barrier
disruption in a mouse model of traumatic brain injury. Neurochemistry International. 2017:in press.
Cai M, Zhang W, Weng Z, Stetler RA, Jiang X, Shi Y, Gao Y, Chen J. Promoting neurovascular recovery
in aged mice after ischemic stroke - Prophylactic effect of omega-3 polyunsaturated fatty acids. Aging
Dis. 2017;8(5)531-545. doi: 10.14336/AD.2017.0520
Dandan Sun, MD, PhD, Professor
Roy A, JH. Goodman, G. Begum, BF. Donnelly, G Pittman, EJ. Weinman, Dandan Sun, and AR.
Subramanya. Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. Am J
Physiol Renal Physiol. 308(4):F366-76, 2015
HB Chang, X Gao, R Nepomuceno, S Hu, Dandan Sun. Na+/H+ exchanger in regulation of platelet
activation and paradoxical effects of cariporide. Expt Neurology. 2015, in press, NIHMS661355
Cong D, W. Zhu, J. S. Kuo, S. Hu, and Dandan Sun. Ion transporters in brain tumors. Curr Med Chem;
22(10):1171-81, 2015 PMID: 25620102
K. T. Kahle, A. R. Khanna, S. L. Alper, N. C. Adragna, P. K. Lauf, Dandan Sun and E. Delpire. "K-Cl
cotransporters in nervous system cell volume regulation and disease. Trends in Molecular Medicine, 2015,
in press
202
Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Dandan Sun, Hübner CA, Cull-
Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in
perinatal white matter injury. Nat Neurosci. 2015 in press, PMID: 25821912
Begum G, Yuan H, Kahle K, Li L, Wang S, Shi Y, Shmukler BE, Yang S, Lin S, Alper SL, Dandan Sun.
Inhibition of WNK3-SPAK/OSR1 kinase signaling reduces brain damage and accelerates neurological
recovery after stroke. Stroke, 2015, in press, NIHMS 692023
NC. Adragna, NB. Ravilla, PK. Lauf, G Begum, AR. Khanna, Dandan Sun, KT. Kahle. Regulated
phosphorylation of the K-Cl cotransporter KCC3 is a potent switch of intracellular potassium content and
cell volume homeostasis. Frontiers Neuroscience, 9:255, 2015.
LD. Harvey, Y. Yin, IY. Attarwala, G. Begum, J. Deng, HQ. Yan, CE. Dixon, Dandan Sun.
Administration of DHA reduces ER stress-associated inflammation and alters microglial/macrophage
activation in traumatic brain injury. ASN Neuro, 7(6), 2015, PMCID: PMC4710127.
W. Zhu, KE. Carney, VM. Pigott, LM. Falgoust, PA. Clark, JS. Kuo, and Dandan Sun. Glioma-mediated
microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1.
Carcinogenesis. 2016 Jun 9. pii: bgw068.
H. Zhao, R. Nepomuceno, X. Gao, LM. Foley, S. Wang, G. Begum, W. Zhu, LM. Falgoust, S. Yang, S-
H. Lin, KT. Kahle, Seth L. Alper, TK. Hitchens, S. Hu, Z. Zhang, and Dandan Sun. Genetic deletion of
the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant
cerebral edema after ischemic stroke. JCBFM. 2016, Feb.,1–14.
Q. Wang, Q. Xu, F. Deng, Z. Xing, Z. WU, B Cen, S. Xu, Z. Zhao, R. Nepomuceno, M. Bhuiyan, Dandan
Sun, J. Wang, A. Ji. Long Non-coding RNA C2dat1 Regulates CaMKIIδ Expression to Promote Neuronal
Survival Through the NF-κB Signaling Pathway. Cell Death & Diseases, 2016, Mar 31;7:e2173.
H. Zhao, KE. Carney, L Falgoust, JW Pan, Dandan Sun, Z. Zhang. Emerging roles of Na+/H+ exchangers
in epilepsy and developmental brain disorders. Progress in Neurobiol. 2016 Mar-May;138-140:19-35.
NIHMSID771733.
F. Boscia, G. Begum, G. Pignataro, R. Sirabella, O. Cuomo, A. Casamassa, Dandan Sun, L. Annunziato.
Glial Na+-dependent ion transporters in pathophysiological conditions. Glia. 2016, 64(10):1677-97. doi:
10.1002/glia.23030.
K. T. Kahle, B. Flores, D. Bharucha-Goebel, J. Zhang, S. Donkervoort, M. Hegde, G. Hussain, B. Liang,
Dandan Sun, C. G. Bönnemann, and E. Delpire. Human peripheral motor neuropathy results from
defective kinase regulation of the KCC3 cotransporter. Science Signaling, 2016, 9(439): ra77. doi:
10.1126/scisignal.aae0546.
Y. Yin, G. Sun, E. Li, K. Kiselyov, Dandan Sun. ER stress and impaired autophagy flux in neuronal
degeneration and brain injury. Ageing Research Reviews 2016, pii: S1568-1637(16)30169-6. doi:
10.1016/j.arr.2016.08.008.
J. Zhang, G. Gao, G. Begum, J. Wang, A. R. Khanna, B. E. Shmukler, G. Daubner, P.Heros, P. Davies, J.
Varghese, M. I. H. Bhuiyan, J.J Duan, J. Zhang, D. Duran, S. L. Alper, Dandan Sun, S. J. Elledge, D. R.
Alessi, K. T. Kahle. Functional kinomics establishes a critical node of volume-sensitive cation-Cl−
cotransporter regulation in the mammalian brain. Scientific Reports, 2016, 6:35986. doi:
10.1038/srep35986.
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M. I. H Bhuiyan, S. Song, H. Yuan, G. Begum, J. Kofler, K. T Kahle, S-S Yang, S-H Lin, S. L Alper, A.
R Subramanya and Dandan Sun. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic
brain damage in hypertensive rats. JCBFM. 2016, pii: 0271678X16675368. NIHMS 840430.
Y. Yin, E. Li, G. Sun, H. Q. Yan, L. M. Foley, L. A. Andrzejczuk, I. Y. Attarwala, T. K. Hitchens, K.
Kiselyov, C. E. Dixon, Dandan Sun. Effects of DHA on hippocampal autophagy and lysosome function
after traumatic brain injury. Mol Neurobiol. 2017. NIHMS 864940.
Kejie Yin, MD, PhD, Assistant Professor
Yu D, Fan C, Zhang W, Wen Z, Hu L, Yang L, Feng Y, Yin KJ, Mo X. Neuroprotective effect of
nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep
hypothermic low flow. J Neurol Sci. 2015 Oct; 357(1-2):119-25.
Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered Long Non-
coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.
Experimental Neurology 2016; 277:162-70.
Wen Z, Yu D, Zhang W, Fan C, Hu L, Feng Y, Yang L, Wu Z, Chen R, Yin KJ, Mo X. Association
between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-
analysis of epidemiological observational studies. Ital J Pediatr. 2016 Feb 3; 42(1):12. doi:
10.1186/s13052-016-0222-2.
Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic TA, Chen YE, Yin KJ, Powell FL,
Martin PM, Grant MB, Busik JV. Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in
Diabetic Retinopathy. EBioMedicine. 2016 Sep;11:138-150. doi: 10.1016/j.ebiom.2016.08.013. Epub
2016 Aug 8.
Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered Long Non-
coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.
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Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ. Long Non-coding RNA Malat1 regulates
cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 2017 February; 37(7):1797-
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Tang X, Liu K, Hamblin MH, Yin KJ. Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic
brain injury. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0556-9. [Epub ahead of print]
Yang X, Liu K, Hamblin MH, Steller A, Chen J, Yin KJ. MicroRNA-15a/16-1 antagomir ameliorates
ischemic brain injury in experimental stroke. Stroke 2017 May 25. pii: STROKEAHA.117.017284. doi:
10.1161/STROKEAHA.117.017284. [Epub ahead of print]
Feng Zhang, MD, PhD, Assistant Professor
Leak RK, Li P, Zhang F (Co-first), Sulaiman HH, Weng Z, Wang G, Stetler RA, Shi Y, Cao G, Gao Y,
Chen J. APE1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from
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Wang J, Xia J, Zhang F, Shi Y, Wu Y, Pu H, Liou A, Leak RK, Yu X, Chen L, Chen J. Galectin-1-
secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury. Sci Rep. 2015
Apr 10;5:9621.
Sun BL , He MQ, Han XY, Sun JY, Yang MF, Yuan H, Fan CD, Zhang S, Mao LL, Li DW, Zhang ZY,
Zheng CB, Yang XY, Li YV, Stetler RA, Chen J, Zhang F. Intranasal Delivery of Granulocyte Colony-
Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats. Mol
Neurobiol. 2016 Jan;53(1):320-30.
Fu XY, Yang MF, Cao MZ, Li DW, Yang XY, Sun JY, Zhang ZY, Mao LL, Zhang S, Wang FZ, Zhang
F, Fan CD, Sun BL. Strategy to Suppress Oxidative Damage-Induced Neurotoxicity in PC12 Cells by
Curcumin: the Role of ROS-Mediated DNA Damage and the MAPK and AKT Pathways. Mol Neurobiol.
2016 Jan;53(1):369-78.
Wang H, Shi H, Yu Q, Chen J, Zhang F, Gao Y. Sevoflurane Preconditioning Confers Neuroprotection
via Anti-apoptosis Effects. Acta Neurochir Suppl. 2016;121:55-61.
Shi Y, Zhang L, Pu H, Mao M, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak R, Keep R, Ji X,
and Chen J. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption
and long-term ischemic reperfusion brain injury. Nat Commun, 2016 Jan 27;7:10523.
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C,
Homanics GE, Cao G, Bennett MV, Chen J. APE1/Ref-1 facilitates recovery of gray and white matter and
neurological function after mild stroke injury. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3558-67.
PMID: 27274063.
Yang T, Sun Y, Lu Z, Leak RK, and Zhang F. 2016. The impact of cerebrovascular aging on vascular
cognitive impairment and dementia. Ageing Res Rev. 2017 Mar;34:15-29. PMID: 27693240.
Sun Y, Yang T, Leak RK, Chen J, and Zhang F. Preventive and protective roles of dietary Nrf2 activators
against central nervous system diseases. CNS Neurol Disord Drug Targets. 2017; 16(3): 326-338. PMID:
28042770.
Sun Y, Yang T, Mao L, and Zhang F. Sulforaphane protects against brain diseases: roles of cytoprotective
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Vascular Neurology
Ashutosh Jadhav, MD, PhD, Assistant Professor of Neurology
Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial Experience
with the AXERA 2 Femoral Access System in Neurovascular Procedures. Interventional Neuroradiology.
2015 May 26.
Grandhi R, Zhang X, Jadhav AP, Horowitz MB, Ducruet AF, Jankowitz BT, Jovin TG. Femoral
Arteriotomy Closure using the Mynx Vascular Closure Device: A Profile of Device Efficacy and
Complications. Interventional Neuroradiology. 2015 May 26.
Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in Patients
Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015
May 2.
205
Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right
sided weakness. J Clin Neurosci. 2015 Mar 18.
Tonetti DA, Jadhav AP, Ducruet AF. A rare marginal tentorial artery to ophthalmic artery anastomosis:
an anatomic case report. J Clin Neurosci. 2015 Apr;22(4):773-4.
Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and
right sided weakness. J Clin Neurosci. 2015 Mar 18.
Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in
Patients Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc
Dis. 2015 May 2.
Grandhi R, Zhang X, Jadhav AP, Horowitz MB, Ducruet AF, Jankowitz BT, Jovin TG. Femoral
Arteriotomy Closure using the Mynx Vascular Closure Device: A Profile of Device Efficacy and
Complications. Interventional Neuroradiology. 2015 May 26.
Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial
Experience with the AXERA 2 Femoral Access System in Neurovascular Procedures. Interventional
Neuroradiology. 2015 May 26.
Aghaebrahim A, Giurgiutiu DV, Jankowitz BT, Jovin T, Jadhav AP. NeuroImages: Ischemic stroke
after Pellet Embolization. Neurology 2015 Jun 9;84(23):2383.
Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar artery occlusion
and review of the literature. BMJ Case Rep. 2015 Jun 8;2015.
Rangaraju S, Streib C, Aghaebrahim A, Jadhav A, Frankel M, Jovin TG. Relationship Between Lesion
Topology and Clinical Outcome in Anterior Circulation Large Vessel Occlusions. Stroke. 2015
Jul;46(7):1787-92.
Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar artery occlusion
and review of the literature. J Neurointerv Surg. 2015 Jun 10.
Aspirin Response Test role in platelet transfusion following intracerebral hemorrhage. Engel-Haber E,
Horev A, Chablani P, Bornstein NM, Jadhav A, Jovin TG, Reddy V, Hammer MD. Clin Neurol Neurosurg. 2015 Oct;137:12-4.
Kenmuir CL, Jovin T, Jadhav A. Cerebral Venous Sinus Thrombosis in Users of a Hormonal Vaginal
Ring. Obstet Gynecol. 2015 Oct;126(4):830-3.
Haussen DC, Jadhav A, Jovin T, Grossberg J, Grigoryan M, Nahab F, Obideen M, Lima A, Aghaebrahim
A, Gulati D, Nogueira RG. Endovascular Management vs Intravenouse Thrombolysis for Acute Stroke
Secondary to Carotid Artery Dissection: Local Experience and Sysstematic Review. Neurosurgery. 2015
Oct 21. [Epub ahead of print]
Goyal M, Jadhav AP, Wilson AT, Nogueira RG, Menon BK. Shifting bottlenecks in acute stroke
treatment. J Neurointerv Surg. 2015 Dec 16. pii: neurintsurg-2015-012151.
Jadhav AP, Ducruet AF, Jankowitz BT, Jovin TG. Management of Bilateral Carotid Occlusive
Disease. Interv Neurol. 2016 Mar;4(3-4):96-103.
206
Aghaebrahim A, Streib C, Rangaraju S, Kenmuir CL, Giurgiutiu DV, Horev A, Saeed Y, Callaway
CW, Guyette FX, Martin-Gill C, Pacella C, Ducruet AF, Jankowitz BT, Jovin TG, Jadhav AP.
Streamlining door to recanalization processes in endovascular stroke therapy. J Neurointerv Surg.
2016 Apr 5.
Goyal M, Jadhav AP, Bonafe A, Diener H, Mendes Pereira V, Levy E, Baxter B, Jovin T, Jahan R,
Menon BK, Saver JL; SWIFT PRIME investigators. Analysis of Workflow and Time to Treatment
and the Effects on Outcome in Endovascular Treatment of Acute Ischemic Stroke: Results from the
SWIFT PRIME Randomized Controlled Trial. Radiology. 2016 Apr 19:160204.
Al-Bayati AR, Nichols J, Jovin TG, Jadhav AP. Thiamine Deficiency Presenting as Intraventricular
Hemorrhage. Stroke. 2016 May 10.
Levitt MR, Albuquerque FC, Gross BA, Moon K, Jadhav AP, Ducruet AF, Crowley RW. Venous
sinus stenting in patients without idiopathic intracranial hypertension. J Neurointerv Surg. 2016 May
19.
Reznik ME, Espinosa-Morales AD, Jumaa MA, Zaidi S, Ducruet AF, Jadhav AP. Endovascular
thrombectomy in the setting of aortic dissection. J Neurointerv Surg. 2016 May 19.
Paolini S, Jadhav AP. Teaching NeuroImages: Posterior reversible encephalopathy syndrome
resulting in hydrocephalus. Neurology. 2016 Jun 7;86(23):e242-3.
Jadhav AP, Wechsler LR. Patient selection for stroke thrombectomy: Is CT head good enough?
Neurology. 2016 Jul 19;87(3):242-3.
Goyal M, Jadhav AP. Denominator fallacy revisited. J Neurointerv Surg. 2016 Jul 28.
Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA,
Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An Educational and Administrative
Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine
Service. Am J Med. 2016 Sep 9.
Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O'Brien S, Fisher M, Haley EC, Khatri P, Saver J,
Levine S, Levy H, Rymer M, Wechsler L, Jadhav A, McNeil E, Waddy S, Pryor K. Selecting Patients
for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection. Stroke. 2016 Nov
1.
Haussen DC, Jadhav A, Rebello LC, Belagaje S, Anderson A, Jovin T, Aghaebrahim A, Gulati D,
Wells B, Frankel M, Nogueira RG. Internal Carotid Artery S-Shaped Curve as a Marker of
Fibromuscular Dysplasia in Dissection-Related Acute Ischemic Stroke. Interv Neurol. 2016 Sep;5(3-
4):185-192.
Jadhav AP, Aghaebrahim A, Horev A, Giurgiutiu DV, Ducruet AF, Jankowitz B, Jovin TG. Stent
Retriever-Mediated Manual Aspiration Thrombectomy for Acute Ischemic Stroke. Intervent Neurol
2017;6:16-24.
207
Kenmuir CL, Starr M, Jadhav AP. Restricted Diffusion of the Bilateral Inferior Olivary Nuclei After
Severe Hypoglycemia. Neurohospitalist 2016.
Jadhav AP, Aghaebrahim A, Horev A, Giurgiutiu DV, Ducruet AF, Jankowitz B, Jovin TG. Stent
Retriever-Mediated Manual Aspiration Thrombectomy for Acute Ischemic Stroke. Intervent Neurol
2017;6:16-24.
Alan N, Nwachuku E, Jovin TJ, Jankowitz BT, Jadhav AP, Ducruet AF. Management of iatrogenic
direct carotid cavernous fistula occurring during endovascular treatment of strokes. World
Neurosurg. 2017 Feb 6. pii: S1878-8750(17)30135-3.
Kashkoush AI, Ma H, Agarwal N, Panczykowski D, Tonetti D, Weiner GM, Ares W, Kenmuir C,
Jadhav A, Jovin T, Jankowitz BT, Gross BA. Cerebral venous sinus thrombosis in pregnancy and
puerperium: A pooled, systematic review. J Clin Neurosci. 2017 May;39:9-15.
Tudor Jovin, MD, Associate Professor of Neurology
Grandhi R, Zwagerman NT, Zhang X, Chen SH, Jadhav AP, Jovin T, Jankowitz BT. Initial Experience
with the AXERA 2 Femoral Access System in Neurovascular Procedures, Interv Neuroradiol. 2015 May
26.
Khatri P, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B,
Ciccone A, Dávalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD,
Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SC, Mitchell P, Mocco J, Muir K, Nogueira RG,
Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White PM, Zaidat OO, Liebeskind
DS, Fulton R, Lees KR; VISTA-Endovascular Collaboration.State of acute endovascular therapy: report
from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke. 2015
Jun;46(6):1727-34.
Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ,
Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Devlin TG, Lopes
DK, Reddy V, du Mesnil de Rochemont R, Jahan R; SWIFT PRIME Investigators. Solitaire™ with the
Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT
PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire
revascularization device with IV tPA with IV tPA alone in acute ischemic stroke. Int J Stroke. 2015
Apr;10(3):439-48.
Chen SH, Grandhi R, Deibert CP, Jovin TG, Gardner PA, Ducruet AF. Coil herniation following intra-
arterial verapamil infusion for the treatment of cerebral vasospasm: Case report and literature review.
Interv Neuroradiol. 2015 Apr;21(2):184-7.
Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right
sided weakness. J Clin Neurosci. 2015 Mar 18. pii: S0967-5868(15)00066-1.
Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A.Predictors of Outcome in Patients
Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015
May 2.
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Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ,
Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin
TG, Lopes DK, Reddy VK, de Rochemont RD, Singer OC, Jahan R; SWIFT PRIME Investigators. Stent-
Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke. N Engl J Med. 2015 Apr 17.
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Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA,
Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL,
Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo JH, Holmstedt CA,
Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn SI, Swartz RH, Barber PA, Coutts SB,
Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, Hill
MD; ESCAPE Trial Investigators.Randomized assessment of rapid endovascular treatment of ischemic
stroke.N Engl J Med. 2015 Mar 12;372(11):1019-30.
Sheth SA, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO, Saver
JL; for the SWIFT Trialists. Rapid learning curve for Solitaire FR stent retriever therapy: evidence from
roll-in and randomized patients in the SWIFT trial.J Neurointerv Surg. 2015 Feb 12.
McTaggart RA, Jovin TG, Lansberg MG, Mlynash M, Jayaraman MV, Choudhri OA, Inoue M, Marks
MP, Albers GW; DEFUSE 2 Investigators. Alberta stroke program early computed tomographic scoring
performance in a series of patients undergoing computed tomography and MRI: reader agreement,
modality agreement, and outcome prediction. Stroke. 2015 Feb;46(2):407-12.
Menon BK, Qazi E, Nambiar V, Foster LD, Yeatts SD, Liebeskind D, Jovin TG, Goyal M, Hill MD,
Tomsick TA, Broderick JP, Demchuk AM; Interventional Management of Stroke III
InvestigatorsDifferential Effect of Baseline Computed Tomographic Angiography Collaterals on Clinical
Outcome in Patients Enrolled in the Interventional Management of Stroke III Trial. Stroke. 2015
May;46(5):1239-44.
Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, Román LS, Serena J, Abilleira
S, Ribó M, Millán M, Urra X, Cardona P, López-Cancio E, Tomasello A, Castaño C, Blasco J, Aja L,
Dorado L, Quesada H, Rubiera M, Hernandez-Pérez M, Goyal M, Demchuk AM, von Kummer R,
Gallofré M, Dávalos A; REVASCAT Trial Investigators. Thrombectomy within 8 Hours after Symptom
Onset in Ischemic Stroke. N Engl J Med. 2015 Apr 17. [Epub ahead of print]
Lopez-Cancio E, Salvat M, Cerda N, Jimenez M, Codas J, Llull L, Boned S, Cano LM, Lara B, Molina
C, Cobo E, Davalos A, Jovin TG, Serena J; REVASCAT investigators. Phone and Video-Based
Modalities of Central Blinded Adjudicaton of Modified Rankin Scores in an Endovascular Stroke Trial.
Stroke. 2015 Dec;46(12):3405-10.
Urra X, Abilleira S, Dorado L, Ribo M, Cardona P, Millan M, Chamorro A, Molina C, Bobo E, Davalos
A, Jovin TG, Gallofre M; Mechanical Thrombectomy in and Outside the REVASCAT Trial: Insights
From a Concurrent Population-Based Stroke Registry Catalan. Stroke Code and Reperfusion Consortium.
Stroke. 2015 Dec;46(12):3437-42.
Broderick JP, Berkhemer OA, Palesch YY, Dippel DW, Foster LD, Roos YB, van der Lugt A, Tomsick
TA, Majoie CB, van Zwam WH, Demchuck AM van Oostenbrugge RJ, Khatri P, Lingsma HF, Hill MD,
Roozenbeek B, Jauch EC, Jovin TG, Tan B, von Kummer R, Molina CA, Goyal M, Schonewille WJ,
Janis LS, Simpson KN; Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic
Stroke: Pooled Analysis of Interventional Management of Stroke III and Multicenter Randomized Clinical
Trial of Endovascular Therapyfor Acute Ischemic Stroke in the Netherlands Data. IMS II and MR CLEAN
Investigators. Stroke. 2015 Dec;46(12):3416-22.
209
Albers GW, Goyal M, Johan R, Bonafe A, Diener HC, Levy EI, Pereira VM, Cognard C, Cohen DJ,
Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin
TG, Lopes DL. Reddy VK, du Mesnil de Rochemont R, Singer OC, Bammer R, Saver JL. Ischemic core
and hypoperfusion volumes predict infarct size in SWIFT PRIME. Ann Neurol. 2015 Oct 17.
Chaisinanunkul N, Adeoye O, Lewis FJ, Grotta JC, Broderick J, Jovin TG, Nogueira RG, Elm JJ, Graves
T, Berry S, Lees KR, Barreto AD, Saver JL; DAWN Trial and MOST Trial Steering Committees;
Additional contributors from DAWN Trail Steering Committee. Adopting a Patient-Centered Approach
to Primary Outcome Analysis of Acute Stroke Trials Using a Uitlity-Weighted Modified Rankin Scale.
Stroke. 2015 Aug;46(8):2238-43.
Engel-Haber E, Horev A, Chablani P, Bornstein NM, Jadhav A, Jovin TG, Reddy V, Hammer MD,
Aspirin Response Test role in platelet transfusion following intracerebral hemorrhage. Clin Neurol
Neurosurg. 2015 Oct;137:12-4.
Rangaraju S, Streib C, Aghaebrahim A, Jadhav A, Frankel M, Joving TG. Relationship Between Lesion
Toplogy and Clinical Outcome in Anterior Circulation Large Vessel Occlusions. Stroke. 2015
Jul;46(7);1787-92.
Liebeskind DS, Jahan, R, Nogueira RG, Jovin TG, Lutsep HL, Saver JL; SWIFT Investigators. Early
arrival at the emergency department is associated with better collaterals, smaller established infarcts and
better clinical outcomes with endovascular stroke therapy: SWIFT study. J Neurointerv Surg. 2015 May
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KhatriP, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B,
Ciccone A, Davalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD,
Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SC, Mitchell P, Mocco J, Muir K, Nogueira RG,
Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White PM, Zaidat OO, Liebesking
DS, Bulton R, Lees KR; VISTA-Endowvascular Collaboration. State of acute endovascular therapy:
report from the 12th thrombolysis, thrombectomy, and acute stroke therapy conference. Stroke. 2015
Jun;46(6):1727-34.
Chen SH, Grandhi R, Beibert CP, Jovin TG, Gardner PA, Ducruet AF. Coil herniation following intra-
arterial verapamil infusion for the treatment of cerebral vasospasm: Case report and literature review.
Interv Neuroradiol. 2015 Apt;21(2):184-7.
Palesch YY, Yeatts SD, Tomsick TA, Foster LD, Demchuk AM, Khatri P, Hill MD, Jauch EC, Jovin TG,
Yan B Von Kummer R, Molina CA, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson, C,
Spilker J, Carrrozzella J, Ryckborst KJ, Janis LS, Simpson A, Simpson KN, Broderick JP; Interventional
Management of Stroke III Investigators. Twelve-Month Clinical and Quality-of-Life Outcomes in the
Interventional Management of Stroke III Trial. Stroke. 2015 May;46(5):1321-7.
Demel SL, Jovin TG, Jadhav AP. Metronidazole toxicity presenting with acute onset of aphasia and right
sided weakness. J Clin Neurosci. 2015 Jul;22(7):1199-200.
Menon BK, Qazi E, Nambiar V, Foster LD, Yeatts SD, Liebeskind D, Jovin TG, Goyal M, Mill MD<
Tomsick TA, Broderick JP, Demchuk AM; Interventiaonal Management of Stroke III Investigators.
Differential Effect of Baseline Computed in the Interventional Management of Stroke III Trial. Stroke.
2015 May;46(5):1239-44.
210
Sheth SA, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO, Saver
JL; Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomized
patients in the SWIFT trial. For the SWIFT Trialists. J Neurointerv Surg. 2015 Feb. 12.
Batal O, Jentzer J, Balaney B, Kolia N, Hickey G, Dardari Z, Reddy V, Jovin T, Hammer M, Forcsan J,
Schmidhofer M. The prognostic significance of troponin I elevation in acute ischemic stroke. J Crit Care.
2015 Sep 25.
Haussen DC, Jadhav A, Jovin T, Grossberg J, Grigoryan M, Nahab F, Obideen M, Lima A, Aghaebrahim
A, Gulati D, Nogueira RG. Endovascular Management vs Intravenous Thrombolysis for Acute Stroke
Secondary to Carotid Artery Dissection: Local Experience and systematic Review. Neurosurgery. 2015
Oct 21.
De Rango, P, Brown MM, Shaturvedi S, Howard VJ, Jovin T, Mazya MV, Paciaroni M, Manzone A,
Farchioni L, Caso V. Summary of Evidence on Early Carotid Intervention for Recently Symptomatic
Stenosis Based on Meta-Analysis of Current Risks. Stroke. 2015 Dec;46(12):3423-36.
Vagal AS, Sucharew H, Prabhakaran S, Khatri P, Jovin T, Michel P, Wintermark, M. Final infarct volume
discriminates outcome in mild strokes. Neuroradiol J. 2015 Aug;28(4):404-8.
MacIsaac RL, Khatri P, Bendszus M, Bracard S, Broderick J, Campbell B, Ciccone A, Davalos A, Davis
SM, Demchuk A, Diener HC, Dippel D, Donnan GA, Fiehler J, Fiorella D, Goyal M, Hacke W, Hill MD,
Jahan R, Jauch E, Jovin T, Kidwll CS, Liebeskind D, Majoie CB, Martins SC, Mitchell P, Mocco J, Muir
KW, Nogueira R, Saver JL, Schonewille, WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, White
P, Zaidat O, Lees KR: VISTA Endovascular collaboration. A collaborative sequential meta-analysis of
individual patient data from randomized trials of endovascular therapy and tPAvs. tPA alone for acute
ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential
meta-analysis performed within the VISTA-Endovascular collaboration. Int J Stroke. 2015 Oct;10Suppl
A100:136-44.
Tomsick TA, Foster LD, Liebeskind DS, Hill MD, Carrozella J, Goyal M, von Kummer R, Demchuk AM,
Dzialowski I, Puetz V, Jovin T, Morales H, Palesch YY, Broderick J, Khatri P, Yeatts SD; IMS III
Investigators. Outcome Differences between Intra-Arterial Iso- and Low-Osmolality Iodinated
Radiographic Contract Media in the Interventional Management of Stroke III Trial. AJNR Am J Neuroradiol. 2015 Nov;36(11):2074-81.
Abou-CheblA, Yeatts SD, Yan B, Cockroft K, Goyal M, Jovin T, Khatri P, Meyers P, Spilker J, Sugg R,
Wartenberg KE, Tomsick T, Broderick J, Hill MD. Pact of eneral Anesthesia on Safety and Outcomes in
the Endovascular Arm of Intervential Management of Stroke (IMS) II Trial. Stroke. 2015 Aug;
46(8):2142-8.
Morales A, Parry PV, Jadhav A, Jovin T. A novel route of revascularization in basilar arter occlusion and
review of the literature. J Neurointerv Surg. 2015 Jun 10.
Ribo M, Molina CA, Cobo E, Cerda N, Tomasello A, Quesada H, De Miquel MA, Millan M, Castano C,
Urra X, Sanroman L, Davalos A, Jovin T; REVASCAT Trial Investigators. Association Between Time
to Reperfusion and Outcome Is Primarily Driven by The Time From Imaging to Reperfusion. Stroke. 2016
Apr;47(4):999-1004.
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Lavine SD, Cockroft K, Hoh B, Bambakidis N, Khalessi AA, Woo H, Riina H, Siddiqui A, Hirsch JA,
Chong W, Rice H, Wenderoth J, Mitchell P, Coulthard A, Signh TJ, Phatorous C, Khangure M, Klurfan
P, terBrugge K, Iancu D, Funnarsson T, Jansen O, Muto M, Szikora I, Pierot L, Brouwer P, Gralla J,
Renowden S, Andersson T, Fiehler J, Turjman F, White P, Januel AC, Spelle L, Kulcsar Z, Chapot R,
Spelle L, Biondi A, Dima S, Taschner C, Szajner M, Krajina A, Sakai N, Matsumaru Y, Yoshimura S,
Ezura M, Fujinaka T, Iihara K, Ishii A, Higashi T, Hirohata M, Hydo A, Ito Y, Kawanishi M, Kiyosue H,
Kobayashi E, Kobayashi S, Kuwayama N, Matsumoto Y, Miyachi S, Murayama Y, Nagata I, Nakahara
I, Nemoto S, NiimiY, Oishi H, Satomi J, Satow T, Sugiu K, Tanaka M, Terada T, Yamagami H, Diaz O,
Lylyk P, Jayaraman MV, Patsalides A, Gandhi DC, Lee SK, Abrusso T, Albani B, Ansar SA, Arthur AS,
Baxter BW, Bulsara KR, Chen M, Delgado Almandoz JE, Fraser JF, Heck DV, Hetts SW, Hussian MS,
Klucznik RP, Leslie-Mawzi TM, Mack WJ, McTaggart RA, Meyers PM, Mocco J, Prestigiacomo CJ,
Pride GL, Rasmussen PA, Starke RM, Sunenshine PJ, Tarr RW, Frei DF, Ribo M, Nogueira RG, Zaidat
OO, Jovin T, Linfante I, Yavagal D, Liebeskind D, Novakovic R, Pongpech S, Rodesch G, Soderman M,
terBrugge K, Taylor A, Krings T, Orbach D, Biondi A, Picard L, Suh DC, Tanaka M, Shang HQ. Training
Guidelines for Endovascular Ischemic Stroke Intervention: An International Multi-Society Consensus
Document. AJNR Am J Neuroradiol. 2016 Feb 18.
Goyal M, Jadhav AP, Bonafe A, Diener H, Mendes Pereira V, Levy E, Baxter B, Jovin T, Jahan R, Menon
BK, Saver JL; SWIFT PRIME investigators. Analysis of Workflow and Time to Treatment and the
Effects on Outcome in Endovascular Treatment of Acute Ischemic Stroke: Results from the SWIFT
PRIME Randomized Controlled Trial. Radiology. 2016 Apr 19:160294.
Menon BK, Sajobi TT, Zhang Y, Rempel JL, Shuaib A,Thornton J, Williams D, Roy D, Poppe AY, Jovin
TG, Sapkota B, Baxter BW, Krings T, Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Lum C,
Dowlatshahi D, Eesa M, Lowerison MW, Kamal NR, Demchuk AM, Hill MD, Goyla M. Analysis of
Workflow and Time to Treatment on Thrombectomy Outcome in the ESCAPE Randoized Controlled
Trial. Circulation. 2016 Apr 13.
Lavine SD, Cockroft K, Hoh B, Bambakidis N, Khalessi AA, Woo H, Riina H, Siddiqui A, Hirsch JA,
Chong W, Rice H, Wenderoth J, Mitchell P, Coulthard A, Signh TJ, Phatorous C, Khangure M, Klurfan
P, terBrugge K, Iancu D, Funnarsson T, Jansen O, Muto M, Szikora I, Pierot L, Brouwer P, Gralla J,
Renowden S, Andersson T, Fiehler J, Turjman F, White P, Januel AC, Spelle L, Kulcsar Z, Chapot R,
Spelle L, Biondi A, Dima S, Taschner C, Szajner M, Krajina A, Sakai N, Matsumaru Y, Yoshimura S,
Ezura M, Fujinaka T, Iihara K, Ishii A, Higashi T, Hirohata M, Hyodo A, Ito Y, Kawanishi M, Kiyosue
H, Kobayashi E, Kobayashi S, Kuwayama N, Matsumato Y, Miyachi S, Murayama Y, Nagata I, Nakahara
I, Nemoto S, Niimi Y, Oishi H, Satomi J, Satow T, Sugiu K, Tanaka M, Terada T, Yamagami H, Diaz O,
Lylyk P, Jayaraman MV, Patsalides A, Gandhi CD, Lee SK, Abrusso T, Albani B, Ansari SA, Arthur AS,
Baxter BW, Bulsara KR, Chen M, Dalgado Almandoz JE, Fraser JF, Heck DV, Hetts SW, Hussain MS,
Klucznik RP, Leslie-Mawzi TM, Mack WJ, McTaggart RA, Meyers PM, Mocco J, Prestigiacomo CJ,
Pride GL, Rasmussen PA, Starke RM, Sunenshine PJ, Tarr RW, Frei DF, Ribo M, Nogueira RG, Zaidat
OO, Jovin T, Linfante I, Yavagal D, Liebeskind D, Novakovic R, Pongpech S, Rodesch G, Soderman M,
terBrugge K, Taylor A, Krings T, Orbach D, Biondi A. Picard L, Suh DC, Tanaka M, Zhang HQ. Training
guidelines for Endovascular Ischemic Stroke Intervention: An Internaitonal Multi-Society Consensus
Document. Neuroradiology. 2016 Apr 13.
English JD, Yavagal DR, Gupta R, Janardhan V, Zaidat OO, Xavier AR, Nogueira RG, Kirmani JF, Jovin
TG. Mechanical Thrombectomy-Ready Comprehensive Stroke Center Requirments and Endovascular
Stroke Systems of Care: Recommendations from the Endovascular Stroke Standards Committee of the
Society of Vascular and Interventional Neurology (SVIN). Interv Neurol. 2016 Mar;4(3-4):138-50. Epub
2016 Feb 19.
212
Rangaraju S, Frankel M, Jovin TG. Prognostic Value of the 24-Hour Neurological Examination in
Anterior Circulation Ischemic Stroke: A post hoc Analysis of Two Randomized Controlled Stroke Trials.
Interv Neurol. 2016 Mar;4(3-4):120-9. Doi: 10.1159/000442530. Eupub 2016 Jan 6.
Jadhav AP, Ducruet AF, Jankowitz BT, Jovin TG. Management of Bilateral Carotid Occlusive Disease.
Interv Neurol. 2016 Mar;4(3-4):96-103. Doi: 10.1159/000442530. Epub 2016 Jan 6.
Al-Ajlan FS, Goyal M, Demchuk AM, Minhas P, Sabiq F, Assis Z, Willinsky R, Monanera WJ, Rempel
JL, Shuaib A, Thornton J, Williams D, Roy D, Poppe AY, Jovin TG, Sapkota BL, Baxter BW, Krings T,
Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Lum C, Dowlatshahi D, Shankar JJ, Barber PA,
Hill MD, Menon BK; ESCAPE Trial Investigators. Intra-Arterial Therapy and Post-Treatment Infarct
Volumes: Insights From the ESCAPE Randomized Controlled Trial. Stroke. 2016 Mar;47(3):777-81.
Campbell BC, Hill MD, Rubiera M, Menon BK, Demchuk A, Donnan GA, Roy D, Thornton J, Dorado
L, Bonafe A, Levy EI, Diener HC, Hernandez-Perez M, Pereira VM, Blasco J, Quesada H, Rempel J,
Jahan R, Davis SM, Stouch BC, Mitchell PJ, Jovin TG, Saver JL, Goyal M. Safety and Efficacy of
Solitaire Stent Thrombectomy: Individual Patient Data Meta-Analysis of Randomized Trials. Stroke.
2016 Mar;47(3):798-806.
Leiva-Salinas C, Patrie JT, Xin W, Michel P, Jovin T, Wintermark M. Prediciton of Early Arterial
Recananilzation and Tissue Fate in the Selection of Patients With the Greatest Potential to Benefit From
Intravenous Tissue-Type Plasminogen Activator. Stroke. 2016 Feb;47(2):397-403. Epub 2015 Dec 22.
Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, Davalos A, Majoie CB,
van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg
LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millan M, Davis SM, Roy D, Thornton J, Roman
LS, Ribo M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD,
Jovin TG; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a
meta-analysis of individual patient data from five randomized trials. Lancet. 2016 Feb. 18.
Al-Ajlan FS, Goyal M, Demchuk AM, Minhas P, Sabiq F, Assis Z, Willinsky R, Montanera WJ, Tempel
JL, Shuaib A, Thornton J, Williams D, Roy D, Poppe AY, Jovin TG, Sapkota BL, Vaxter BW, Drings T,
Silver FL, Frei DF, Fanale C, Tampieri D, Teirtelbaum J, Lum C, Dowlatshahi D, Shankar JJ, Barber PA,
Hill MD, Menon BK; ESCAPE Trial Investigators. Intra-Arterial Therapy and Post-Treatment Infarct
Volumes: Insights from the ESCAPE Randomized Controlled Trial. Stroke. 2016 Mar;47(3):777-81.
Ribo M, Molina CA, Cobo E, Cerda N, Tomasello A, Quesada H, De Miquel MA, Millan M, Castano C,
Urra X, Sanroman L, Davalos A, Jovin T; REVASCAT Trial Investigators. Association Between Time
to Reperfusion and Outcome is Primarily Driven by the Time From Imaging to Reperfusion. Stroke. 2016
Apr;47(4):999-1004.
Warach SJ, Luby M, Albers GW, Bammer R, Bivard A, Campbell BC, Derdeyn C, Heit JJ, Khatri P,
Lansberg MG, Liebeskind DS, Majoie CB, Marks MP, Menon BK, Muir KW, Parsons MW, Vagal A,
Yoo AJ, Alexandroz AV, Baron JC Fiorella DJ, Furlan AJ, Puig J, Schellinger PD, Wintermark M; Stroke
Imaging Researh (STIR) and VISTA-Imaging Investigators. Imaging Research Roadmap III Imaging
Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials: Consensus Recommendations and
Further Research Priorities. Stroke. 2016 May;47(5):1389-98.
Al-Bayati AR, Nichols J, Jovin TG, Jadhav AP. Thaimine Deficiency Presenting as Intraventricular
Hemorrhage. Stroke. 2016 Jun;47(6):e95-7.
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Jovin TG, Albers GW, Liebeskind DS; STAIR IX Consortium. Stroke Treatment Academic Industry
Roundtable: The Next Generation of Endovascular Trials. Stroke. 2016 Oct;47(10):2655-65.
Saver JL, Goyla M, van der Lugt A, Menon BK, Majoie CB, Dippel DW, Campbell BC, Nogueira RG,
Demchuk AM, Tomesello A, Cardona P, Devlin TG, Frei DF, Du Mesnil de Rochemont R, Berkhemer
OA, Jovin TG, Siddiqui AH, van Zwam WH, Davis SM, Castano C, Sapkota BL, Fransen PS, Molina C,
van Oostenbrugge RJ, Chamarro A, Lingsma H, Silver FL, Donnan GA, Shuaib A, Brown S, Stouch B,
Mitchell PJ, Davalos A, Roos YB, Hill MD; HERMES Collaborators. Time to Treatment With
Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis. JAMA. 2016 Sep
27;316(12):1279-88.
Sequeira D, Martin-Gill C, Kesinger MR, Thompson LR, Jovin TG, Massaro LM, Gayette FX.
Characterizing Strokes and Stroke Mimics Transported by Helicopter Emergency Medical Services.
Prehosp Emerg Care. 2016 Nov-Dec;20(6):723-728.
Ali Raza S, Xiang B, Jovin TG, Liebeskind DS, Shields R, Nogueira RG, Rangaraju S; Trevo2 study
group. Pittsburgh response to endovascular therapy score as a apre-treatment prognostic tool: External
validation in Trevo2. Int J Stroke. 2016 Nov. 3.
Trivedi D, Navid F, Balzer JR, Joshi R, Lacomis JM, Jovin TG, Althouse AD, Gleason TG. Aggressive
Aortic Arch and Carotid Replacement Strategy for Type A Aortic Dissecton Improves Neurologic
Outcomes. Ann Thorac Surg. 2016 Mar;101(3):896-903.
Ganesh A, Al-Ajlan FS, Sabiq F, Assis Z, Rempel JL, Butcher K, Thornton J, Kelly P, Roy D, Poppe AY,
Jovin TG, Devlin T, Baxter BW, Drings T, Casaubon LK, Frei DF, Choe H, Tampieri D, Teirtelbaum J,
Lum C, Mandzia J, Phillips SJ, Bang OY, Almekhlafi MA, Coutts SB, Barber PA, Sajobi T, Demchuk
AM, Eesa M, Hill MD, Goyal M, Menon BK; ESCAPE Trial Investigators..Infarc In a New Territory
After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment
for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to
Recanalization Times). Stroke. 2016 Nov 10. Pii: STROKEEAHA.116.014852.
Hou Q, Patrie JL, Xin W, Michel P, Jovin T, Eskandari A, Wintermark M. Number need to screen for
acute revascularization trials in sroke: Prognostic and predictive imaging biomarkers. Int J Stroke. 2016
Nov 2.
Haussen DC, Jadhav A, Rebello LC, Belagaje S, Anderson A, Jovin T, Aghaebrahim A, Gulati D, Wells
B, Frankel M, Nogueira RG. Internal Carotid Artery S-Shaped Curve as a Marker of Fibromuscular
Dysplasia in Dissection-Related Acute Ischemic Stroke. Interv Neurol. 2016 Sep;5(3-4):185-192.
Shams T, Zaidat O, Yavagal D, Xavier A, Jovin T, Janardhan V. Society of Vascualr and Interventional
Neurology (SVIN) Stroke Interventional Laboratory Consensus (SILC) Criteria: A 7M Management
Approach to Developing a Stroke Interventional Laboratory in the Era of Stroke Thrombectomy for Large
Vessel Occlusions. Interv Neurol. 2016 Jun;5(1-2):1-28.
Saposnik G, Goyal M, Majoie C, Dippel D, Roos Y, Demchuk A, Menon B, Mitchell P, Campbell B,
Davalos A, Jovin T, Hill MD; HERMES collavorators and the Stroke Outcomes Research working group
(SORCan). Visual aid tool to improve decision making in acute stroke care. Int J Stroke. 2016 Aug 16.
Rangaraju S, Jovin TG, Frankel M, Schonewille WJ, Algra A, Kappelle LJ, Nogueira RG; BASICS Study
Group..Neurologic Examination at 24 to 48 Hours Predicts Funtional Outcomes in Basilary Artery
Occlusion Stroke. Stroke. 2016 Oct;47(10):2534-40.
214
Brinjiki W, Duffy S, Burrows A, Hacke W, Liebeskind D, Majoie CB, Dippel DW, Siddiqui AH, Khatri
P, Baxter B, Nogeuira R, Gounis M, Jovin T, Kallmes DF. Correlation of imaging and histopathology of
thrombi in acute ischemic stroke with etiology and outcome: a systematic review. J Neurointerv Surg. 2016 May 10.
Lopez-Cancio E, Jovin TG, Cobo E, Cerda N, Jimenez M, Gomis M, Hernandez-Perez M, Caceres C,
Cardona P, Lara L, Renu A, Llull L, Boned S, Muchada M, Davalos A. Endovascular treatment improves
cognition after stroke. A secondary analysis of REVASCAT trial. Neurology 2017 (in Press)
Shireman T, Wang K, Saver J, Goyal M, Bonafe A, Diener HC, Elad Levy E, Pereira VM, Albers G,
Cognard C, Hacke W, Jansen O, Jovin TG, Mattle H, Nogueira N, Siddiqui A, Yavagal D, Devlin T,
Lopes D, Reddy V, du Mesnil de Rochemont R, Jahan R, Vilain K, House J, Lee JM and Cohen D. Cost-
effectiveness of Solitaire Stent Retriver Thrombectomy for Acute Ischemic Stroke: Results from SWIFT-
PRIME. Stroke 2017 (in Press)
Davalos A, Cobo E, Molina C, Chamorro A, Miquel MA, San Roman L, Serena J, Lopez-Cancio, E, Ribo
M, Millan M, Urra X, Cardona P, Tomasello A, Castano C, Plasco J, Aja L, Rubiera M, Gomis M, Renu
A, Lara B, Marti-Fabregas J, Jankowiwtz BJ, Cerda N, Jovin TG; for the REVASCAT Trial Investigators.
Benefit of thrombectomy is sustained at 12 months post treatment for acute ischemic stroke. One year
results of the REVASCAT Trial. Lancet Neurology. 2017 (in Press).
Vivek Reddy, MD, Assistant Professor of Neurology
Kenmuir CL, Hammer M, Jovin T. Reddy V, Wechsler L, Jadhav A. Predictors of Outcome in Patients
Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores. J Stroke Cerebrovasc Dis. 2015
Jul;24(7):1685-9.doi:10.1016/j.jstrokecerebrovasdis.2015.03.042. Epub 2015 May 2.
Saver JL, Goyal M, Bonafe A, Diener HC, Levy El, Pereira VM, Albers GW, Cognard C, Cohen DJ,
Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Devlin TG, Lopes
DK, Reddy V, du Mesnil de Rochemont R, Jahan R; SWIFT PRIME Investigators. Solitaire with the
Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT
PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire
revascularization device with IV tPA with IV tPA alone in acute ischemic stroke. Int J Stroke, 2015
Apr;10(3):439-48. Doi:10.1111/ijs.12459.
Saver JL, Goyal M, Bonafe A, Diener HC, Levy El, Pereira VM, Albers GW, Cognard C, Cohen DJ,
Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin
TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahan R; SWOFT PRIME
Investigators. Stent-retriever thromectormy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015 June 11;372(24):2285-95. Doi:10.1056/NEJMoa1415061. Epub 2015 Apr 17.
Albers GW, Goyal M, Jahan R, Bonafe A, Diener HC, Levy El, Pereira VM, Cognard C, Cohen DJ, Hacke
W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG,
Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Bammer R, Saver JL. Ischemic core and
hypoperfusion volumes predict infarct size in SWIFT PRIME. Ann Neurol. 2015 Oct 17.
Doi:10.1002/ana.24543.
Batal O, Jentzer J, Balaney B, Kolia N, Hickey G, Dardari Z, Reddy V, Jovin T, Hammer M, Gorcsan J,
Schmidhofer M. The prognostic significance of troponin I elevation in acute ischemic stroke. J Crit Care.
2016 Feb;31(1):41-7. Doi:10.1016/j.jcrc.2015.09.018. Epub 2015 Sep 25.
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Marcelo Rocha, MD, PhD, Assistant Professor of Neurology
Rocha M, Delfyett WT, Agarwal V, Aghaebrahim A, Jadhav A and Jovin T. Diagnostic Accuracy of
Emergency CT Angiography for Presumed Tandem Internal Carotid Artery Occlusion before Acute
Endovascular Therapy (2017) Journal of Neurointerventional Surgery (accepted).
Rocha M and Jovin TG Fast Versus Slow Progressors of Infarct Growth in Large Vessel Occlusion
Stroke: Clinical and Research Implications (2017) Stroke 48(9):2621-2627.
Jadhav AP, Kenmuir CL, Aghaebrahim A, Wechsler LR, Hammer MD, Starr MT, Molyneaux BJ, Rocha
M, Guyette FX, Martin-Gill C, Ducruet AF, Gross BA, Jankowitz BT and Jovin TJ. Inter-facility transfer
directly to the neuroangiography suite in acute ischemic stroke patients undergoing thrombectomy (2017)
Stroke DOI: 10.1161/STROKEAHA.117.016946.
Matthew Starr, MD, Assistant Professor of Neurology
Jadhav AP, Bouslama M, Aghaebrahim A, Rebello LC, Starr MT, Haussen DC, Ranginani M, Whalin
MK, Jovin TG, Nogueira RG, Monitored Anesthesia Care vs. Intubation for Vertebrobasilar Stroke
Endovascular Therapy. JAMA Neurol. 2017;74(6):704-709. Doi:10.1001/jamaneurol.2017.0192.
Jadhav AP, Kenmuir CL, Aghaebrahim A, Limaye K, Wechsler LR, Hammer MD, Starr MT et al.
Interfacility Transfer Directly to the Neuroangiography Suite in Acute Ischemic Stroke Patients
Undergoing Thrombectomy. Stroke. 2017;48:00-00.)
Lawrence Wechsler, MD, Professor and Chair of Neurology
Wechsler LR. Advantages and limitations of teleneurology. JAMA Neurol 2015; 72:349-354.
Meschia JF, Hopkins LN, Altafullah I, Wechsler LR, Stotts G, Gonzales NR, Voeks JH, Howard G, Brott
TG. Time from symptoms to carotid endarterectomy or stenting and perioperative risk. Stroke 2015;
46:3540-3542.
Rosenfield K, Matsumura JS, Chaturvedi S, Riles T. Ansel GM, Metzger DC, Wechsler L, Jaff MR, Gray
W, ACT I Investigators. Randomized trial of stent versus surgery for asymptomatic carotid stenosis.
NEJM, 2016; 374:1011-1020.
Warach SJ, Luby M, Algers GW, Bammer R, Bivard A, Campbell BCV, Derdeyn C, Heit JJ, Khatri P,
Lansberg MG, Liebeskind DS, Majoie CBLM, Marks MP, Menon BK, Muir KW, Parsons MW, Vagal
A, Yoo AJ, Alexandrov AV, Baron J-C, Fiorella DJ, Furlan AJ, Puig J. Schellinger PD, Wintermark M,
for the Stroke Imaging Research (STIR) and VISTA-Imaging Investigators. Acute stroke imaging
research roadmap III imaging selection and outcomes in acute stroke reperfusion clinical trials. Stroke
2016;47:1389-1398
Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA,
Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks
JH, Hobson RW 2nd; CREST Investigators. Long-term results of stenting versus endarterectomy for
carotid-artery stenosis. NEJM 2016; 17:374(11):1021-31. Epub 2016 Feb 18.
Lees KR, Khatri P, STAIR IX Collaborators. Stroke treatment academic industry roundtable
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Jadhav AP, Wechsler LR. Patient selection for stroke thrombectomy: Is CT head good enough?
Neurology 2016; 87:242-243.
Steinberg GK, Kondziolka D, Wechsler LR, Lunsford LD, Coburn ML, Billigen JB, Kim AS, Johnson
JN, Bates D, King B, Case C, McGrogan M, Yankee EW, Schwartz NE. Clinical outcomes of transplanted
modified bone marrow-derived mesenchymal stem cells in stroke: A phase 1/2a study. Stroke 2016;
47:1817-1824.
Lees KR, Khatri P, STAIR IX Collaborators. Stroke treatment academic industry roundtable
recommendations for individual data pooling analyses in stroke. Stroke 2016; 47:2154-2159.
Wechsler LR, Demaerschalk BM, Schwamm LH, Adeoye OM, Audebert HJ, Fanale CV, Hess DC,
Majersik JJ, Nystrom KV, Reeves MJ, Rosamond WD, Switzer JA; on behalf of the American Heart
Association Stroke Council; Council on Epidemiology and Prevention; and Council on Quality of Care
and Outcomes Research. Telemedicine Quality and Outcomes in Stroke. Published online ahead of print.
Stroke 2016/Stroke 2017; 48:e3-e25.
Cramer SC, Wolf SL, Adams HP Jr, Chen D, Dromerick AW, Dunning K, Ellerbe C, Grande A, Janis S,
Lansberg MG, Lazar RM, Palesch YY, Richards L, Roth E, Savitz SI, Wechsler LR, Wintermark M,
Broderick JP. Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National
Institutes of Health StrokeNet. Stroke. 2017 Mar; 48(3):813-819.
Northshore Neurology
Lazarus Mayoglou, DO
Martín-Alguacil N, Cooper RS, Aardsma N, Mayoglou L, Pfaff D, Schober J. Terminal innervation of the
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Schober J, Aardsma N, Mayoglou L, Pfaff D, Martín-Alguacil N. Terminal innervation of female
genitalia, cutaneous sensory receptors of the epithelium of the labia minora. Clin Anat. 2015
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