Case presentation on

Dengue Fever,Dengue shock

syndrome

• Dengue fever also known as breakbone fever,

is a mosquito-borne topical disease caused by

the dengue virus

• Dengue fever, a benign syndrome caused

by several arthropod-borne viruses

Dengue fever

ETIOLOGY• Vector• Mosquito• Primarily Aedes Aegypti• Most female Ae. Aegypti

•Dengue virus▫Flavivirus: Single Stranded RNA virus▫Serotypes: DEN-1 to DEN-4

Incidence

▫2.5 billion people in over 100 endemic countries

▫50 million people infected annually with 500,000

cases of DHF and approx 20,000 deaths

Dengue Clinical Syndromes:

1.Undifferentiated fever;

2.Classic dengue fever;

3.Dengue hemorrhagic fever, or DHF; and

4.Dengue shock syndrome, or DSS.

Dengue Fever

Classical Dengue fever or Break bone fever is

an acute febrile viral disease frequently

presenting with headaches, bone or joint pain,

muscular pains,rash,and leucopenia

• Dengue hemorrhagic fever is a severe, often fatal, febrile disease caused by dengue viruses.

• It is characterized by capillary permeability, abnormalities of hemostasis, and, in severe cases, a protein-losing shock syndrome

4 Necessary Criteria:1.Fever, or recent history of acute fever 2.Hemorrhagic manifestations 3.Low platelet count (100,000/mm3 or less) 4.Objective evidence of “leaky capillaries:” • elevated hematocrit (20% or more over

baseline) • low albumin • pleural or other effusions

Dengue shock syndrome is the fourth clinical syndrome of dengue fever a sever form of Dengue hemorrhagic fever • 4 criteria for DHF

• Evidence of circulatory failure manifested indirectly by all of the following: • Rapid and weak pulse • Narrow pulse pressure (< 20 mm Hg) ORhypotension for age

• Cold, clammy skin and altered mental status

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Pathophysiology

Prevention

Prognosis

• Dengue fever < 1% mortality• Dengue hemorrhagic fever approx 2.5%

mortality• Primarily children

• Dengue shock up to 47% mortality