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Dendreon Presentation
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20-Oct-2014 -
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Transcript of Dendreon Presentation
![Page 1: Dendreon Presentation](https://reader034.fdocuments.us/reader034/viewer/2022051816/54450983b1af9f476c8b465e/html5/thumbnails/1.jpg)
Dendreon Corporation (DNDN):
Targeting Cancer, Transforming Lives™
Anam Ali
Jair Campos
Bill Halkiadakis
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Biotech Industry Analysis
Growing at the rate of 13.95% yearly U.S Biotechnology industry is expected to touch mark of $131.8 Billion
by the end of 2010. Companies in the Biotech Industry draw heavily upon research in genetic
engineering or recombinant DNA technology to produce biological compounds (such as human insulin or vaccines) in large quantities for commercial use.
Biotechnology will play an important role in Agricultural sector by developing large number of genetically modified seeds.
The biomedical sector accounts for the major share of overall biotech industry in US and will continue to dominate in future as well.
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Biotech Industry
Biotech Industry
Distribution
Participants
Customers
Pricing
Marketing& Promotion
RegulationJoint Ventures/
Alliances
Products
R&D and Manufacturing
Competitors
Markets
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Biotech & Pharmaceutical Market (worldwide)
Source: IMS World Review 2007Source: IMS World Review 2007
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Worldwide Incidence of Prostate Cancer
Prostate cancer kills 200,000 men annually worldwide. Men over fifty or w/familial history are more susceptible
Red and swollen areas indicate a higher rate. North America world leader Europe and Japan close second
Courtesy of Science Creative QuarterlyCourtesy of Science Creative Quarterly
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Company Overview
Dendreon was founded in 1992, in Seattle, Washington, and is traded on NASDAQ under the ticker DNDN.
Company is engaged in discovering, developing and commercialization of novel therapeutics that harness the immune system to fight cancer.
Employs about 232 people between their headquarters in Seattle and their manufacturing facility in Morris Plains, NJ.
Dendreon has a market cap of $618.67 million, and reported sales of $111,000.00 million in 2008.
The company's key products and services include the following:– Provenge (sipuleucel-T)– Neuvenge (lapuleucel-T)– Trp-p8– CEA– CA-9– Anti-Serine Protease
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Defining the Business
Who is being satisfied?– Individual Patients, Physicians, Large Scale
Purchasers, Governments
What is being satisfied?– Medical treatment for diseases
How are customer needs being satisfied?– Through the discovery and development of
breakthrough medicines
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Dendreon’s Purpose
Dendreon’s uniqueness, innovation, and scientific advancement leads to introducing new therapeutic vaccines to treat forms of cancer
Transforming lives, offering hope, and offering reliable, feasible & manageable treatment for men in late stage of prostrate cancer
Heading towards becoming a leader in revolutionizing the treatment of prostrate cancer patients and immunological diseases worldwide
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Key Points of the Firm
Provides expertise in antigen identification, engineering and cell processing
Active cellular immunotherapy holds promise providing patients with a clinical benefit, such as survival, and low toxicity
Provenge has shown significant positive results in clinical trials.– Dendreon studied 512 patients, and saw a 22% survival rate increase.
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Treatment Cycle for PROVENGE®
1. Active cellular immunotherapy (ACI) is a treatment approach that capitalizes on the power of live human cells to re-engage the patient's own immune system to fight cancer.
2. The goal of Dendreon’s approach is to turn the immune system "back on" to elicit a specific and long-lasting response against cancer.
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Our Potential Customers
Late stage prostrate cancer patients
Cancer clinical centers, physicians, hospitals
Research/scientific community
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Porter’s Five Forces
Barriers to Entry - High – High Capital requirements, high start up cost, economies of scales offer larger
companies higher competitive advantage, complexity of design.
Buyer’s Power – Medium– Many buyers to choose from, HMO’s & PPO’s dictate what choice of drugs is allotted to
customers
Suppliers Power – Low – Limited amount of products to offer the firm
Threat of Substitutes - Medium – Bio-tech firms can continuously produce more products & more patents can be filed
Nature of Rivalry Within the Industry – High– Intense competition with others in specialty market segment– High exit barriers because of enormous R&D investments
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• Innova
tive th
erapeutic
vacc
ine – Late stage
• Less
toxic
vs. c
hemo
• Firs
t move
r adva
ntage
• Exc
lusive patent ri
ghts
• Company size
• Lack of financial resources
• No products out on the market
• At the mercy of the FDA
• FDA re
jection
• Marke
t size
• Take
over b
y larg
er
competito
rs
• Unfavo
rable re
sults
from R
&D & cl
inical
trials
• Future innovation &
technological advances
• Niche products with high
potential market penetration
• No competition from
generics expected for yrs
• Fast growth expected in
incidence of cancer
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Firms Problems
Approval delays from FDA - more data required not likely available till 2010.
Rejection & lawsuits from agencies of cancer patients who wanted to access the drug now, investors, and patient advocates. This puts pressure on the firm to allocate more time & funds towards more clinical trials.
Logistics and distribution costs likely to be higher than GVAX, more added steps involved.
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Recommendations
Growth Strategy
1. Diversified Product Pipeline - expand portfolio beyond oncology drugs
2. Needs to do financing to get more cash, diluting current investors
3. Raise cash from secondary offering of the common stock. Stock price is high so more cash can be generated this way
4. Market alignment and promotion.
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Biotechnology Industry
Very Large Range in Industry Capitalization
Top 6 companies represent 80 percent of the market.
Dramatic increase in revenue (119 percent) over the last 5 years.
Little to Negative Revenue among Startups.
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Industry Growth (2004 – 2008)
2004 - 2008 Actual Revenue ($ Millions)
$-
$10,000
$20,000
$30,000
$40,000
$50,000
$60,000
1 2 3 4 5
Years
Rev
enue
Actual Revenue Growth
0.00%
5.00%
10.00%
15.00%
20.00%
25.00%
1 2 3 4 5
Years
Rat
e of G
row
th
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Industry Projections
Financial Analysis Methodology
Projected growth of Revenues are declining since companies are getting more mature.
48 percent increase in revenue over the next years.
Large changes in capitalization & revenue is expected from the smaller companies within market segment. .
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Projected Growth (2009 – 2013)
2009 - 2013 Projected Revenue
$-
$10,000
$20,000
$30,000
$40,000
$50,000
$60,000
$70,000
$80,000
$90,000
1 2 3 4 5
Years
Rev
enue
Projected Revenue Growth
0.00%
2.00%
4.00%
6.00%
8.00%
10.00%
12.00%
14.00%
1 2 3 4 5
Years
Rat
e of G
row
th
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Evaluation of Industry Trend Growth Results
The Financial Growth of large established Companies can be possibly predicted based on the previous financial results. It can be reasonably predicted in the very short term, but any financial estimates spanning several years most probably will be highly inaccurate.
A five year Analysis may be too unrealistic in a market segment as fluid as Biotechnology. The next Market leader may not even be in the picture.
The Financial Growth of a company like Dendreon cannot be predicted using traditional Industry Trend Growth. The long term growth of Dendreon will be the result of Disruptive New Technologies and Visionary Products that have a huge financial potential for the firm.
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Financial Analysis (Stock Price)
Phenomenal Stock Price Explosion in the last 30 days.
$ 4.30 on April 03, 2009
$ 20.08 on April 24, 2009
$ 607 Million Market Cap on April 3
$ 1.97 Billion Market Cap on April 24, 2009.
Company Fundamentals remain the same. The company has not produce a any profit over the last five years.
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Financial Analysis (Fundamentals)
Revenues2008 2007 2006 2005
(In Million)
Revenue 0.11 100.0% 0.74 100.0% 0.27 100.0% 0.21 100.0%
Other Revenue 0 0.0% 0 0.0% 0 0.0% 0 0.0%
Total Revenue 0.11 100.00% 0.74 100.00% 0.27 100.00% 0.21 100.00%
Income Statement2008 2007 2006 2005
(In Million)
Total operating Revenue 0.11 52.4% 0.74 352.4% 0.27 128.6% 0.21 100.0%
Total Costs and Expenses 70.59 81.4% 102.36 118.1% 97.63 112.6% 86.67 100.0%
Net Income -70.48 81.5% -101.62 117.5% -97.36 112.6% -86.46 100.0%
For the last four years Dendreon has been consistently loosing money from $ 86.46 Million in 2005 to $ 70.48 Million in 2008.
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Ratio Analysis
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Financial Analysis (Conclusion)
Do Traditional Financial Analysis Tools apply for a company like Dendreon ?
How does someone perform a valuation analysis for a company that it’s future Growth will be the result of Disruptive New Technologies and Visionary Products?
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Questions?