DELETION SEQUENCES IN FMOC SPPS - Bachem · Deletion sequences resulting from couplings that cannot...

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F. Hofmann, G. Sambeth, F. Dettner, R. Schönleber Bachem AG, Bubendorf, Switzerland // www.bachem.com DELETION SEQUENCES IN FMOC SPPS - ROOT CAUSE ANALYSIS AND PREVENTION STRATEGIES APIs Peptides Derivatives Biochemicals Custom Synthesis

Transcript of DELETION SEQUENCES IN FMOC SPPS - Bachem · Deletion sequences resulting from couplings that cannot...

Page 1: DELETION SEQUENCES IN FMOC SPPS - Bachem · Deletion sequences resulting from couplings that cannot be driven to completion can be "converted" to truncated sequences by quantitative

F. Hofmann, G. Sambeth, F. Dettner, R. SchönleberBachem AG, Bubendorf, Switzerland // www.bachem.com

DELETION SEQUENCES IN FMOC SPPS - ROOT CAUSE ANALYSIS AND PREVENTION STRATEGIES

APIs Peptides Derivatives Biochemicals Custom Synthesis

Generic APIs - Bachem€¦ · APIS * Bachem provides ... • high-demand APIs available from stock ... It is a potent and selective activator of the parathyroid hormone receptor (PTH1R)

Generic APIs - Bachem€¦ · APIS * Bachem provides ... • high-demand APIs available from stock ... It is a potent and selective activator of the parathyroid hormone receptor (PTH1R)

SHAPING THE FUTURE TOGETHER - Bachem · nology gained in popularity versus the competing tBoc technology. It is a safer and less polluting way to make peptides. Bachem was first to

SHAPING THE FUTURE TOGETHER - Bachem · nology gained in popularity versus the competing tBoc technology. It is a safer and less polluting way to make peptides. Bachem was first to

A Sister-Strand Exchange Mechanism For recA-Independent Deletion … ·  · 2002-07-08A Sister-Strand Exchange Mechanism For recA-Independent Deletion of Repeated DNA Sequences in

A Sister-Strand Exchange Mechanism For recA-Independent Deletion … ·  · 2002-07-08A Sister-Strand Exchange Mechanism For recA-Independent Deletion of Repeated DNA Sequences in

CSDAP Deletion

CSDAP Deletion

AVL Tree Deletion

AVL Tree Deletion

Bachem Ba349 Natter- D. Myhra - Schiffer Military History

Bachem Ba349 Natter- D. Myhra - Schiffer Military History

Generic APIs Flyer English - Bachem · sales.jp@bachem.com Europe, Africa, Middle East and India Bachem AG Tel. +41 58 595 2020 sales.ch@bachem.com . Title: Generic APIs Flyer English

Generic APIs Flyer English - Bachem · [email protected] Europe, Africa, Middle East and India Bachem AG Tel. +41 58 595 2020 [email protected] . Title: Generic APIs Flyer English

Ghrelin, Leptin and Obestatin - Bachem · Ghrelin, Leptin and Obestatin 2 GHRELIN, LEPTIN AND OBESTATIN PEPTIDES OFFERED BY BACHEM Ghrelin is an endogenous peptide discovered by Kojima

Ghrelin, Leptin and Obestatin - Bachem · Ghrelin, Leptin and Obestatin 2 GHRELIN, LEPTIN AND OBESTATIN PEPTIDES OFFERED BY BACHEM Ghrelin is an endogenous peptide discovered by Kojima

Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation deletion, insertion Seq. 1: 515 EVIRMQDNNPFSFQSDVYSYG EVI.

Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation deletion, insertion Seq. 1: 515 EVIRMQDNNPFSFQSDVYSYG EVI.

2009 - Copy Deletion

2009 - Copy Deletion

PregnancyandSmoothelin-likeProtein1(SMTNL1)Deletion ... ·  · 2015-07-10PregnancyandSmoothelin-likeProtein1(SMTNL1)Deletion PromotetheSwitchingofSkeletalMuscletoaGlycolytic ...

PregnancyandSmoothelin-likeProtein1(SMTNL1)Deletion ... ·  · 2015-07-10PregnancyandSmoothelin-likeProtein1(SMTNL1)Deletion PromotetheSwitchingofSkeletalMuscletoaGlycolytic ...

SAMPLING VARIATIONS OF SEQUENCES FOR STRUCTURED … · operations: substitution, deletion, and insertion of a char-acter. Mongeau and Sankoff [12] add two operations mo-tivated by

SAMPLING VARIATIONS OF SEQUENCES FOR STRUCTURED … · operations: substitution, deletion, and insertion of a char-acter. Mongeau and Sankoff [12] add two operations mo-tivated by

Autosomal Deletion Syndromes

Autosomal Deletion Syndromes

Word-internal /t,d/ deletion in spontaneous speech ... · cally also syllable-final, unless they are resyllabified in connected speech. By examining word-internal sequences we were

Word-internal /t,d/ deletion in spontaneous speech ... · cally also syllable-final, unless they are resyllabified in connected speech. By examining word-internal sequences we were

 · Prader-WilIi syndrome Chromosome 15q14 deletion syndrome Chromosome 15q25 deletion syndrome HCD Chromosome 15q26-qter deletion syndrome Levy-Shanske syndrome Chromosome 16p deletion

 · Prader-WilIi syndrome Chromosome 15q14 deletion syndrome Chromosome 15q25 deletion syndrome HCD Chromosome 15q26-qter deletion syndrome Levy-Shanske syndrome Chromosome 16p deletion

BACHEM HALF-YEAR REPORT 2017 · 1 Bachem Half-Year Report 2017 FIRST HALF-YEAR 2017 IN BRIEF ... (ETH Zurich) was the moderator of ... the US and by further expansion at the plant

BACHEM HALF-YEAR REPORT 2017 · 1 Bachem Half-Year Report 2017 FIRST HALF-YEAR 2017 IN BRIEF ... (ETH Zurich) was the moderator of ... the US and by further expansion at the plant

Deletion of cytoplasmic sequences of the nerve growth factor ...

Deletion of cytoplasmic sequences of the nerve growth factor ...

MARKETS & CUSTOMERS - Bachem · and postponements of projects meant that this market dynamics could not be fully translated into sales figures. Above all, Bachem was able to identify

MARKETS & CUSTOMERS - Bachem · and postponements of projects meant that this market dynamics could not be fully translated into sales figures. Above all, Bachem was able to identify

cosmetic peptides BACHEM - Fujifilm

cosmetic peptides BACHEM - Fujifilm

RATIONAL DELETION

RATIONAL DELETION