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Decreased Beta Power As A Predictor Of Memory Encoding
Dr. Simon Hanslmayr
University of Birmingham, School of Psychology
www.uni-konstanz.de/oscillations-and-cognition/
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Why brain oscillations?
Brain Oscillations = Communication Mechanisms! (Varela et al., 2001; Nat Neurosci; Fries et al., 2005; Trends in Cogn Sci)
Large Scale
Phase:
Local Scale
Power:
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The Classic Model „Fire together wire together“
Time
Brain Oscillations = Neural Synchronization = Memory
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Sync Desync
-0.2 0 0.2 0.4 0.6 0.8 1 1.2 1.4 3 7
13
35
100
Time [sec]
Fre
qu
en
cy [H
z]
Gamma
Beta/ Alpha
Theta
???
Theta and Gamma Sync. positively related to memory • Rutishauser et al. (2010) Nature • Fell & Axmacher (2011) Nat Rev Neurosci
How is desynchronization related to memory?
Brain Oscillations and Memory
Staudigl & Hanslmayr (2013) Curr Biol
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Alpha/Beta power decreases predict memory formation
0.05 0.01
Hit vs. Miss
p-level
b – Power (13-20 Hz)
-0.5 0 0.5 1 1.5
Time (sec.)
-20
-10
0
10
Po
we
r (%
)
Hit Miss
Hanslmayr et al. (2009) Cereb Cortex Fellner et al. (2013) NeuroImage
Noh et al. (2014) NeuroImage Long et al. (2013) NeuroImage
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Rem. vs. Forg.
-0.5 0 0.5 1 1.5 2
Fre
qu
en
cy [H
z]
Time [sec.]
4
6
8
10
12
14
16
18
2.5
b
t-values
1.5 2.0
b – Source b – SME
Pcorr<0.05
EEG-fMRI during encoding
SME
Beta x BOLD
SME & Beta
IFG
(~ BA 45/46)
IFG
(~ BA 9)
-0.5
-0.4
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
Eig
en
va
lue
s
BA 9 BA 45/46
Rem Forg.
Hanslmayr et al. (2011) J Neurosci
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• Question
– Are beta power decreases in the left IFG epiphenomenal?
– Are they causally relevant to memory formation?
– Can we entrain beta oscillations in the left IFG and would that impair memory formation?
Summary and Question
EEG-BOLD correlations
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rTMS-EEG and Encoding
left IFG
(~BA 9)
2.5 sec 1.0 – 2.0 sec
18.7 Hz 10.7 Hz
6.8 Hz
Sham [18.7 Hz]
0.5 sec
rTMS (18 pulses)
1 sec
Hypothesis: Entrainment of beta oscillations at left IFG specifically impairs memory encoding
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rTMS-EEG - Behavioral Data
Hanslmayr, Matuschek, Fellner (2014) Curr Biol
*
% R
ecal
led
30
35
40
45
50
18.7 Hz 11.7 Hz 6.8 Hz Sham
Memory Performance
0
10.7 Hz 18.7 Hz 6.8 Hz Sham
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Single Trials
Entrainment Echo
clean EEG
ERP
ERP Pow.
EEG contaminated by artefacts
rTMS-EEG – Evidence for Entrainment
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0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8
0.5
0.0
-0.5
Am
plit
ude
[m
v]
Time after last TMS pulse [sec.]
ERPs (17.5 – 19.5 Hz)
18.7 Hz
Sham
rTMS-EEG – Evidence for Entrainement
Hanslmayr, Matuschek, Fellner (2014) Curr Biol
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rTMS-EEG – Evidence for Entrainement
3.6 3.9
t-val
TMS
pcorr<0.005
Hanslmayr, Matuschek, Fellner (2014) Curr Biol
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rTMS-EEG – Evidence for Entrainement
-0.04
-0.02
0.00
0.02
0.04
0.06
0.08
0.10
0.4 - 0.9 0.9 - 1.4
low Entr
high Entr
*
n.s.
0
2
4
6
8
10
-2
-4
Me
mo
ry I
mp
airm
ent
(Sh
am
- 1
8.7
)
High vs. Low Entrainment Group
0.4 – 0.9 sec 0.9 – 1.4 sec .0000
.1000
.2000
.3000
.4000
.5000
.6000
.7000
.8000
18.7 Hz 10.7 Hz 6.8 Hz
Low Entr.
High Entr.
80
0
10
20
30
40
50
60
70
ER
P P
ow
er
[% s
ig.
ch
an
ge
]
Beta Echo (TMS – Sham) (0.4 – 0.9 sec; 17.5 – 19.5 Hz)
*
Hanslmayr, Matuschek, Fellner (2014) Curr Biol
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Open Question
• Higher frequencies? tACS
Verena Braun
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The information via desynchronization hypothesis
No Synchrony Low Synchrony High Synchrony Spikes
0.1 0.2 0.3 0.4 0.5 0.6 0.1 0.2 0.3 0.4 0.5 0.6 0.1 0.2 0.3 0.4 0.5 0.6
0.5
0.0 EEG
0 5 10 15 20 25 30
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8 EEG - Power
Frequency [Hz]
0
1
2
3
4
5
6
No Sync. Low Sync. High Sync.
Entr
opy [
H]
Information
0.1 0.2 0.3 0.4 0.5 0.6 0.7 1
2
3
4
5
0
Entr
opy [
H]
EEG - Power
Information vs. Synchrony
Hanslmayr, Staudigl, Fellner (2012) Front Hum Neurosci
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Take home messages
• Alpha/Beta desynchronization plays a very active and causal role for memory formation and may represent information.
• Brain oscillations can be entrained by external stimulation and observed in terms of echoes.
Wednesday, 4pm-6pm Poster Session 3 Rooms P9-P11
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• Cognition and Oscillations Lab:
Tobias Staudigl (Konstanz Univ.)
Thank you for your attention …
Gerd Waldhauser (Konstanz Univ.)
Marie-Christin Fellner (Konstanz Univ.)
Jonas Matuschek (Konstanz Univ.)
Verena Braun (Birmingham Univ.)
Rolandas Stonkus (Birmingham Univ.)
Sebastian Michelmann (Birmingham Univ.)
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• Funding:
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rTMS-EEG – Evidence for Entrainement
SME Sham (0.0 – 0.5 sec)
8
0.0
- 8
Rem
< F
org
R
em
> F
org
5 10 15 20 25
*
Pow
er
[% s
ignal change]
Frequency [Hz]
18.5 Hz
Relation between entrained frequency and spontaneous frequency
Hanslmayr, Matuschek, Fellner (2014) Curr Biol
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rTMS-EEG – Evidence for Entrainement
14 15 16 17 18 19 20 21 22
1
2
3
4
5
6
Low Dev. High Dev. High Dev.
Num
ber
of subje
cts
SME Peak Frequency
-0.2
-0.1
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.4 - 0.9 0.9 - 1.4
Low Dev
High Dev
70
60
50
40
30
20
10
0
-10
-20
ER
P P
ow
er
[% s
ig. change]
Beta Echo (18.7 Hz – Sham) (17.5 – 19.5 Hz)
0.4 – 0.9 sec 0.9 – 1.4 sec
Low Dev.
High Dev.
*** **
Relation between entrained frequency and spontaneous frequency
Hanslmayr, Matuschek, Fellner (2014) Curr Biol