Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape
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Transcript of Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape
![Page 1: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/1.jpg)
Death, Disease And DarwinDeath, Disease And Darwin
For a full transcript of the presentation,for which these slides were an accompaniment,
please visit:
https://sites.google.com/site/sjlewis55/presentations/sshb2009
![Page 2: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/2.jpg)
Death, Disease and Darwin: Life in 3DThe individual and the fitness landscape
Stephen Lewis
![Page 3: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/3.jpg)
(From Boorse (1987))
![Page 4: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/4.jpg)
Evolutionary medicine is
“the enterprise of trying to find evolutionary explanations for vulnerabilities to disease”
(Randolph Nesse)
![Page 5: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/5.jpg)
Physical State
Expe
rienti
al S
tate
[d]
[b][c]
[a]
(After Lewis (2009))
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(From Wright (1932, 1988))
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(Fig. 2 (Detail) - modified from Wright (1932, 1988))
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G1G2
G3
G4
Fitness
Phenotype
Genotype
P1P2 P3
F1
F2
(After Stearns and Hoekstra (2005))
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![Page 10: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/10.jpg)
(Using Fig. 2 (Detail) (Wright 1932, 1988) as a Fitness Landscape)
![Page 11: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/11.jpg)
Physical State
Expe
rienti
al S
tate
[d]
[c]
(After Lewis (2009))
![Page 12: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/12.jpg)
(Using Fig. 2 (Detail) (Wright 1932, 1988) as a Fitness Landscape)
[d][c]
![Page 13: Death, Disease and Darwin: Life in 3D - The Individual and the Fitness Landscape](https://reader035.fdocuments.us/reader035/viewer/2022081404/558d07d8d8b42aaf168b45f4/html5/thumbnails/13.jpg)
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Death, Disease And DarwinDeath, Disease And Darwin
For a full transcript of the presentation,for which these slides were an accompaniment,
please visit:
https://sites.google.com/site/sjlewis55/presentations/sshb2009