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Revised: 07/2010 CURRICULUM VITAE

: Suzanne Marie de la Monte, M.D., M.P.H. Business Address: Rhode Island Hospital 55 Claverick Street, Room 419 Providence, RI 02903 [[[[ Business Telephone: 401-444-7364 Business Fax: 401-444-2939 E-mail: Suzanne_DeLaMonte_MD@Brown.edu Education

1969-72: A.B. Cornell University 1973-77: M.D. Cornell University Medical College 1977-79: National Institutes of Health Graduate School 1983-84: M.P.H. The Johns Hopkins University, School of Hygiene and Public Health

[[ Postgraduate Training:

Internship and Residencies

1980-1981: Intern in Pathology, The Johns Hopkins Hospital 1981-1983: Assistant Resident, Pathology, The Johns Hopkins Hospital 1983-1984: Assistant Resident, Pediatric and Perinatal Pathology, The Johns Hopkins Hospital 1984-1986: Resident and Fellow, Neuropathology, Massachusetts General Hospital

Research Fellowships:

1975 Research Fellow, American Heart Association, Cornell University Medical College

1977-1979: Research Fellow (Virology), National Cancer Institute, National Institutes of Health

1979-1980: Research Fellow (Neurochemistry), Department of Neurology, Johns Hopkins University School of Medicine

1986-1988: Alzheimer’s Disease Research Fellow, Massachusetts General Hospital, Harvard Medical School

1988-1992 Research Fellow, Departments of Medicine and Pathology, Massachusetts General Hospital, Harvard Medical School

Awards and Honors

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1972 Cum Laude 1975 Harold G. Wolff Research Prize (1st Place), Cornell University Medical College 1976 Harold G. Wolff Research Prize (1st Place), Cornell University Medical Colleg 1977 Louis Gibovsky Memorial Research Prize (Best senior honors thesis), Cornell

University Medical College 1983 Roche Award (1st Place), National Research Forum, Galveston, Texas 1986 Certificate of Merit, Stowell-Orbison Research Award, International Academy of

Pathology, North American Division 1988-1993 Physician-Scientist Award, National Institutes of Aging, N.I.H. 1990 Alzheimer’s Association Research Award 1998 Achievement Award, Universidad Autonoma de Nuevo Leon, Facultad De Ciencias

Biologicas 2000 Alzheimer Award (International) 2001 Master of Arts, ad eundem Brown University 2010 MERIT Award, NIAAA 2010 NIH-NIAAA Council (Nominated, Appointment Pending-2011)

Licenses and Certifications

1981 Maryland License Registration 1984; Massachusetts License Registration, #60260 2001 Rhode Island License-Registration # MD10622 1984 American Board of Anatomic Pathology 1987 American Board of Anatomic Pathology, Special Qualification in Neuropathology

Academic Appointments

1979-1980 Fellow in Neurology, Johns Hopkins University School of Medicine 1980-1984 Fellow in Pathology, Johns Hopkins University School of Medicine 1984-1986 Fellow in Pathology, Harvard Medical School 1987-1989 Instructor in Pathology, Harvard Medical School 1989-1995 Assistant Professor in Pathology, Harvard Medical School 1995-1999 Associate Professor in Pathology, Harvard Medical School 1999-2004 Associate Professor (Res) Pathology 2000- Faculty, Pathobiology Graduate Program, Brown University 2004- Professor (Res) Pathology and Laboratory Medicine 2005- Professor of Clinical Neuroscience 2009- Professor (Res Sch) Pathology and Laboratory Medicine, Neurology, & Neurosurgery

Hospital Appointments

1979-1980 Fellow in Neurology, Johns Hopkins Hospital 1980-1984 Fellow in Pathology, Johns Hopkins Hospital 1984-1986 Fellow in Pathology, Massachusetts General Hospital 1987-1989 Instructor in Pathology, Massachusetts General Hospital 1989-1995 Assistant Pathologist and Neuropathologist, Massachusetts General Hospital

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1995-1999 Associate Pathologist and Neuropathologist, Massachusetts General Hospital 1999-2004 Associate Pathologist and Neuropathologist, Rhode Island Hospital and Miriam

Hospitals 2004- Pathologist and Neuropathologist, Rhode Island and Miriam Hospitals

Other Appointments

1984-1990 Geriatric Medicine Committee, Massachusetts Medical Society 1991-1994 NINDS-NIH Ad hoc study section member: HIV Program Project Grants 1994-1998: Member, AIDS & Related Research Study Section 7, NIH. 1990-1999 Neuropathologist Consultant, New Hampshire Hospital 1998-1999: NINDS-NIH Ad hoc study section member, AIDS & Related Research 2000- Minority Fellowship Training Program, NIH 2001- NCI-NIH Cancer Research Fellowship (F09) Study Section 2002 Awards Committee, American Association of Neuropathologists 2002- Neuropathologist Consultant, Rhode Island State Medical Examiner 2003- American Society for Investigative Pathology, Education Program Committee 2003-2008 NAL, NIH-NIAAA Study section, member 2008- NCI-NIH, NINDS Ad hoc reviewer 2008- Physicians’ Health Committee-Rhode Island Medical Society

Committee Assignments

Hospital and University Committees 1997-1999 Laboratory Safety Committee, Massachusetts General Hospital 1999-2006 Animal Care and Use Plan Committee, Lifespan 2006- IRB2, Lifespan 2002-2003 Neuropathology Faculty Search Committee 2006-2008 Behavioral and Social Sciences Faculty Search Committee, Brown University 2005-2008 Member, Committee on Medical Faculty Affairs 2008-2009 Vice Chair, Medical Faculty Executive Council 2008-2009 Brown University Community Council 2008- Internal Advisory Board, Brown Initiative to Maximize Student Diversity (IMSD) 2009-2010 Chair, Medical Faculty Executive Council

Thesis Committees

2000-2004 Brown University, Pathobiology Graduate Program- Stephanie Lahousse 2003-2005 Brown University, Pathobiology Graduate Program-Julia Xu 2003-2007 Brown University, Pathobiology Graduate Program-Jade J. Carter 2007- Brown University, Pathobiology Graduate Program-Lisa Longato 2010 Brown University, Molecular Pharmacology & Physiology, Teresa Ramirez

Brown University Pathobiology PhD. Advisory Committees

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1999-0 Stephanie Lahousse 2001- Julia Xu 2002-5 Julia Xu, Jade Carter, Stephen Ash, Marlowe Tessmer 2007-8 Lisa Longato 2008-9 Carolyn Duwaerts; Natasha Catlin 2010 Adeola Adebayo; Anika Toorie

Editorial Boards:

1997- Journal of Alzheimer’s Disease 2004 Cellular and Molecular Life Sciences 2009 International Journal of Alzheimer’s Disease

2009 J Neurotransmission 2010 J Diabetes & Metabolism Editorial consultant: 1993- Neurology 1995- Journal of Neuropathology and Experimental Neurology 1997- Laboratory Investigation 1996- New England Journal of Medicine 1998- American Journal of Physiology 2001- Hepatology 2001- Indian Proceedings of the National Academy of Sciences 2003 J Neuroscience; FASEB J; Acta Neuropathologica; JBC; J Cell Biol; BBA: Molec

Basis of Disease; J Neurotrauma; Lifesci 2009 Molecular Neurodegeneration Professional Societies

1980- American Medical Association 1982- US and Canadian Academy of Pathology 1984- Massachusetts Medical Society 1987- American Association of Neuropathologists 1989- American Society of Investigative Pathologists 1999- Research Society on Alcoholism 1999- Society for Neuro-oncology 2004 Rhode Island Medical Womens Association 2006 Rhode Island Medical Society

Teaching Experience:

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1980-1984 Laboratory instructor and tutor, medical school course in pathology, Johns Hopkins School of Medicine

1980-1984 Instructed residents and medical students, anatomic pathology, Johns Hopkins Hospital

1983-1984 Supervised medical students' research projects, Johns Hopkins Medical School 1982-1984 Faculty, The Johns Hopkins Institute of Cytopathology 1984-1987 Conference leader, medical school course in neuropathology, Harvard Medical

School 1984-1999 Instructed residents and medical students, Neuropathology, Massachusetts

General Hospital 1985-1988 Guided residents and medical students through research projects and

publication of original manuscripts 1988-1995 Instructor in Human Nervous System and Behavior Course, Harvard Medical

School 1990-1999 Research laboratory training of post-doctoral fellows, medical, undergraduate,

and high school students; Seminar leader in the Health Sciences Technology-MD (Harvard-MIT) Pathophysiology course.

1999- Instruct residents, fellows, research fellows, and undergraduate, graduate and medical students in pathology, pathobiology, neuropathology, and molecular neuroscience.

1999- Research laboratory training of post-doctoral fellows, medical, undergraduate, and high school students; hands-on research, experimental design, data interpretation, presentation skills, literature review

2002-2003 Course Director, Bio 283: Mechanisms of cellular injury in aging and disease 2007-2008 Course Designer and Instructor: Integrative Neuroscience-Molecular and

Biochemical Mechanisms of Human Neurological Diseases 2008- Module Trainer and Mentor, IMSD-Brown, “Beyond the Hypothesis” 2009-2010 Course Director, Bio 283: Mechanisms of Environmental Mediated Diseases

and Pathology Research Support:

K08 Physician Scientist Award: Analysis of GAP-43 Expression in Alzheimer’s Disease; NIA, 1989-94 Pilot feasibility grant: Analysis of NTP Expression in the Down syndrome mouse model; NIA, 1990-91 Individual Investigator Award: Role of Neuronal Thread Protein in Alzheimer’s Neurodegeneration; American Health Assistance Foundation, 1990-1992. RO1-NS-29793 (P.I. S.M. de la Monte): Analysis of neuronal thread protein expression in Alzheimer’s disease; NINDS, 1992-96 Individual Investigator Award: Diagnostic Aids for Alzheimer’s disease; Abbott Laboratories, 1991-1994 Individual Investigator Award: Diagnostic Aids for Alzheimer’s disease, Cloning of NTP; Molecular Geriatrics Inc, 1994-96

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Training Award: Role of cerebrovascular disease in the pathogenesis of Alzheimer’s disease. American Heart Association, 1996-1997. Investigator Award: AD7c and Neurodegeneration in Alzheimer’s disease; NYMOX Corp., 1996-2002: 152,665/year (J.R. Wands, Co-PI) RO1 AA02666 (PI: Wands JR; Co-Investigator: de la Monte, SM) 08/01/03-7/31/07-no cost extension. Alcohol Effects on the Liver. The major goal of this project is to understand the effects of ethanol on the molecular and cellular mechanisms of hepatocyte growth in vitro and in vivo Investigator Award: Development of in vitro and in vivo models of Alzheimer’s neurodegeneration; NYMOX Corp, 1997-2002 RO1-AA011431 (P.I.-J.R. Wands, Co-PI-S.M. de la Monte, 1996-2003; P.I.-S. M. de la Monte, Co-P.I.-J.R. Wands, 2003-2014): Ethanol, Insulin/IGF Signaling and Neuronal Migration [original title-Characterization of Antibodies to Human IRS-1]. The major goal of this project is to characterize the effects of ethanol on insulin/IGF-I signaling in relation to neuronal migration. The experimental plan includes a mechanistic analysis of how ethanol impairs expression and function of downstream effector molecules that mediate cell motility. Investigator Award: Analysis of oxidative stress and role of anti-oxidant therapy in preventing aging-associated neurodegeneration. Panacea Corp. 2000-2003. SBIR: NIH-National Institute of Alternative Medicine (PI M. Yalpani, Carbomer Inc; de la Monte, Rhode Island Hospital/Lifespan); Screening of natural products from herbal sources for dementia therapy 2000-2001 Institutional Brown/Lifespan COBRA Award-NIH. Project title: Development of transgenic mouse models of neurodegeneration; Microarray screening for differential gene expression with AD7c-NTP-induced neurodegeneration; 2000-2005. R01-AA012908 (P.I.-de la Monte; 2003-2014): Effects of Ethanol on Insulin Signaling in the Brain; The major goal of this project is to investigate the mechanisms and consequences of impaired insulin signaling in the developing and adolescent brain following chronic gestational exposure to ethanol K24-AA016126 (P.I.-de la Monte; 2006-2011): Mid-career investigator award in alcohol-related human disease research. The major goal of this program is to provide resources that will enable the PI to mentor physician-scientists and young investigators, and help them develop careers investigating human alcohol-related diseases. Education begins in the lab with translational research, which subsequently gets extended to human studies as the project evolves. Emphasis is placed on recruiting women and under-represented minorities. R37-AA11431-MERIT Award (P.I.-S.M. de la Monte; 2009-2019): The major goal of this project is to characterize the effects of ethanol on insulin/IGF-I signaling in relation to neuronal function. The experimental plan is to determine of how ethanol impairs expression and function of downstream effector molecules in the brain.

Patents:

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Institutional Ownership: MGH0681.0 (Issued) Inventors: de la Monte and Wands Title: Neural Thread protein gene expression in Alzheimer’s disease Institutional Ownership: MGH02296.0 Inventors: Wands, de la Monte, et al Title: Method of detecting neurological disease or dysfunction Institutional Ownership: MGH (pending) Inventors: de la Monte and Wands Title: Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer’s disease. Institutional Ownership: Lifespan/Brown University (PTC/US98/04731) Inventors; de la Monte and Wands Title: A Method for treating or preventing Alzheimer’s disease Institutional Ownership: Lifespan (pending) Inventors: de la Monte and Wands Title: In vivo gene transfer-mediated neurodegeneration: Models for designing treatments for Alzheimer’s disease.

CURRENT RESEARCH ACTIVITIES:

Direct the research efforts of post-doctoral fellows, research associates, technicians, and students (medical, undergraduate, and high school). Research projects have been focused on the following topics: Fetal alcohol spectrum disorders: Roles of insulin and IGF deficiency and resistance in relation to CNS developmental defects Long-term effects of chronic gestational exposure to alcohol in relation to cognitive-motor impairments—roles of insulin/IGF resistance and oxidative stress Liver-Brain axis of neurodegeneration in peripheral insulin resistance caused by chronic alcohol exposure or obesity/diabetes mellitus Potential therapeutic effects of insulin sensitizer agents in preventing long-term adverse effects of chronic prenatal alcohol exposure. Dietary soy abates long-term neurocognitive deficits caused by chronic alcohol abuse Pathogenesis of alcohol-related peripheral neuropathy and myopathy in experimental animal models and humans: role of insulin resistance Environmental mediators and exacerbators of neurodegeneration: Focus on nitrosamine exposures and additive effects on high dietary fat intake

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Novel peripheral blood biomarkers of alcohol-related neurodegeneration—role of ceramides and other toxic lipids Mechanisms of alcohol-induced neurodegeneration during development and in adult brains. Epigenetic mediators of alcohol-mediated liver and CNS diseases during development and aging in experimental models and humans.

TEACHING AND ACADEMIC LEADERSHIP ROLES Directed laboratory sections of the "Human Nervous System and Behavior" course at Harvard Medical School (1984-1992). Currently teach seminars in the Health Science Technology HST 100 (Harvard-MIT) pathophysiology course. Active member of the clinical Neuropathology staff at the MGH. Assume full-service clinical responsibilities in Neuropathology and General Autopsy Pathology for 12 weeks per year. Work includes sign-out, teaching, leading conferences, and administrative duties. Consultant neuropathologist and lecturer at the New Hampshire Hospital/Dartmouth Medical Center. Guide and assist a number of investigators to perform and interpret in situ hybridization and immunohistochemical studies, as well as analyze histopathological lesions generated experimentally. This role has proven crucial for the successful completion and interpretation of a number of studies conducted at the MGH East Cancer Center where my laboratory is located. In addition, my participation in these and other studies has generated preliminary data required for approval and funding of other principal investigators' independent research awards. Guide residents and fellows through clinical projects to encourage participation in research and academic medicine. Examples of projects completed or in progress: Carried out collaborative research with scientists at the MGH Cancer Center, Cardiovascular Research Center. Direct and supervise undergraduate, medical and graduate student research projects in a laboratory setting Deliver research conferences, grand rounds, seminars, and teaching modules at Brown University and affiliated hospitals 2-4 times per month Mentor to minority summer research trainees (undergraduate and medical school) interested in careers in biomedical science or medicine (1994-present). All trainees participate in research projects and all have completed sufficient work to attain co-authorship on peer-reviewed manuscripts. Mentor to impoverished high school students attending Boston public schools. Supervise homework performance, provide tutoring in all subjects, provide supplementary educational and cultural enrichment experiences, as well as training in laboratory techniques and in the use of computers, including internet research; ensure basic literacy and math skills; provide social counseling for individual growth; communicate closely with teachers to monitor improvement and test performance.

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BIBLIOGRAPHY

1. Gjedde A, de la Monte SM, Caronna JJ. Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. Acta Physiol Scand 1977;100(3):273-81.

2. de la Monte SM, Gupta PK, White CL, 3rd. Systemic Actinomyces infection. A potential complication of intrauterine contraceptive devices. Jama 1982;248(15):1876-7.

3. Charache S, de la Monte S, MacDonald V. Increased blood viscosity in a patient with sickle cell anemia. Blood Cells 1982;8(1):103-9.

4. de la Monte SM, Hutchins GM, Gupta PK. Polymorphous meningitis with atypical mononuclear cells in Sjogren's syndrome. Ann Neurol 1983;14(4):455-61.

5. de la Monte SM, Moore GW, Hutchins GM. Nonrandom distribution of metastases in neuroblastic tumors. Cancer 1983;52(5):915-25.

6. de la Monte SM, Linhares AL, da Rosa AP, Pinheiro FP. Immunoperoxidase detection of Yellow Fever virus after natural and experimental infections. Trop Geogr Med 1983;35(3):235-41.

7. de la Monte SM, Moore GW, Hutchins GM. Patterned distribution of metastases from malignant melanoma in humans. Cancer Res 1983;43(7):3427-33.

8. de la Monte SM, Hutchins GM, Moore GW. Paraneoplastic syndromes and constitutional symptoms in prediction of metastatic behavior of small cell carcinoma of the lung. Am J Med 1984;77(5):851-7.

9. de la Monte SM, Hutchins GM, Moore GW. Compensatory neoplasia: chronic erythrocytosis and neuroblastic tumors. Theor Med 1984;5(3):279-91.

10. de la Monte SM, Hutchins GM, Moore GW. Risk factors for development of lethal sequelae after hepatitis B virus infection in humans. Am J Med 1984;77(3):482-8.

11. de la Monte SM, Dorfman HD, Chandra R, Malawer M. Intraosseous schwannoma: histologic features, ultrastructure, and review of the literature. Hum Pathol 1984;15(6):551-8.

12. de la Monte SM, Hutchins GM. Is suicide a special occupational hazard for physicians? Jama 1984;251(15):1952-3.

13. de la Monte SM, Arcidi JM, Moore GW, Hutchins GM. Midzonal necrosis as a pattern of hepatocellular injury after shock. Gastroenterology 1984;86(4):627-31.

14. de la Monte SM, Hutchins GM, Moore GW. Estrogen and progesterone receptors in prediction of metastatic behavior of breast carcinoma. Am J Med 1984;76(1):11-7.

15. de la Monte SM, Hutchins GM, Moore GW. Endocrine organ metastases from breast carcinoma. Am J Pathol 1984;114(1):131-6.

16. de la Monte SM, Hutchins GM. Follicular proctocolitis and neuromatous hyperplasia with lymphogranuloma venereum. Hum Pathol 1985;16(10):1025-32.

17. de la Monte SM, Hutchins GM. Disseminated Curvularia infection. Arch Pathol Lab Med 1985;109(9):872-4.

18. de la Monte S, Gupta PK, Hutchins GM. Polymorphous exudates and atypical mononuclear cells in the cerebrospinal fluid of patients with Sjogren's syndrome. Acta Cytol 1985;29(4):634-7.

19. de la Monte SM, Moore GW, Monk MA, Hutchins GM. Risk factors for the development and rupture of intracranial berry aneurysms. Am J Med 1985;78(6 Pt 1):957-64.

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20. de la Monte SM, Hutchins GM. Sisters with polysplenia. Am J Med Genet 1985;21(1):171-6.

21. de la Monte SM, Hutchins GM, Gupta PK. Aseptic meningitis, trimethoprim, and Sjogren's syndrome. Jama 1985;253(15):2192.

22. de la Monte S, Castro F, Bonilla NJ, Gaskin de Urdaneta A, Hutchins GM. The systemic pathology of Venezuelan equine encephalitis virus infection in humans. Am J Trop Med Hyg 1985;34(1):194-202.

23. de la Monte SM, Hutchins GM, Moore GW. Peripheral neuroblastic tumors and congenital heart disease. Possible role of hypoxic states in tumor induction. Am J Pediatr Hematol Oncol 1985;7(2):109-16.

24. de la Monte SM, Moore T, Hedley-Whyte ET. Vacuolar encephalopathy of AIDS. N Engl J Med 1986;315(24):1549-50.

25. de la Monte SM, Flickinger J, Linggood RM. Histopathologic features predicting recurrence of meningiomas following subtotal resection. Am J Surg Pathol 1986;10(12):836-43.

26. de la Monte SM, Horowitz SA, Larocque AA, Richardson EP, Jr. Keyhole aqueduct syndrome. Arch Neurol 1986;43(9):926-9.

27. Gabuzda DH, Ho DD, de la Monte SM, Hirsch MS, Rota TR, Sobel RA. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurol 1986;20(3):289-95.

28. de la Monte SM, Moore GW, Hutchins GM. Metastatic behavior of prostate cancer. Cluster analysis of patterns with respect to estrogen treatment. Cancer 1986;58(4):985-93.

29. de la Monte SM, Hutchins GM. Fatal disseminated bacillus Calmette-Guerin infection and arrested growth of cutaneous malignant melanoma following intralesional immunotherapy. Am J Dermatopathol 1986;8(4):331-5.

30. de la Monte SM, Ropper AH, Dickersin GR, Harris NL, Ferry JA, Richardson EP, Jr. Relapsing central and peripheral demyelinating diseases. Unusual pathologic features. Arch Neurol 1986;43(6):626-9.

31. de la Monte SM, Hutchins GM, Moore GW. Metastatic behavior of rhabdomyosarcoma. Pathol Res Pract 1986;181(2):148-52.

32. Milner ME, de la Monte SM, Moore GW, Hutchins GM. Risk factors for developing and dying from necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 1986;5(3):359-64.

33. de la Monte SM, Hutchins GM, Moore GW. Respiratory epithelial cell necrosis is the earliest lesion of hyaline membrane disease of the newborn. Am J Pathol 1986;123(1):155-60.

34. Moore GW, Polacsek RA, Erozan YS, de la Monte SM, Miller RE, Hutchins GM, et al. Multilingual translation techniques in the analysis of narrative medical text. Comput Methods Programs Biomed 1986;22(1):35-42.

35. de la Monte SM, Radowsky M, Hood AF. Congenital granular-cell neoplasms. An unusual case report with ultrastructural findings and a review of the literature. Am J Dermatopathol 1986;8(1):57-63.

36. Rance NE, de la Monte SM, Hutchins GM. Dilatation of the left ventricle in a newborn: probable in utero myocardial infarction. Pediatr Pathol 1986;5(3-4):463-9.

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37. Pomerantz RJ, Kuritzkes DR, de la Monte SM, Rota TR, Baker AS, Albert D, et al. Infection of the retina by human immunodeficiency virus type I. N Engl J Med 1987;317(26):1643-7.

38. Mendelsohn G, de la Monte S, Dunn JL, Yardley JH. Gastric carcinoid tumors, endocrine cell hyperplasia, and associated intestinal metaplasia. Histologic, histochemical, and immunohistochemical findings. Cancer 1987;60(5):1022-31.

39. Seizinger BR, de la Monte S, Atkins L, Gusella JF, Martuza RL. Molecular genetic approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci U S A 1987;84(15):5419-23.

40. Erickson AM, de la Monte SM, Moore GW, Hutchins GM. The progression of morphologic changes in bronchopulmonary dysplasia. Am J Pathol 1987;127(3):474-84.

41. de la Monte SM, Ho DD, Schooley RT, Hirsch MS, Richardson EP, Jr. Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection. Neurology 1987;37(4):562-9.

42. Ozturk M, Berkowitz R, Goldstein D, Bellet D, Wands JR. Differential production of human chorionic gonadotropin and free subunits in gestational trophoblastic disease. Am J Obstet Gynecol 1988;158(1):193-8.

43. Burkhardt CR, Filley CM, Kleinschmidt-DeMasters BK, de la Monte S, Norenberg MD, Schneck SA. Diffuse Lewy body disease and progressive dementia. Neurology 1988;38(10):1520-8.

44. de la Monte SM. Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch Neurol 1988;45(9):990-2.

45. de la Monte SM, Vonsattel JP, Richardson EP, Jr. Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease. J Neuropathol Exp Neurol 1988;47(5):516-25.

46. de la Monte SM, Hutchins GM, Moore GW. Altered metastatic behavior of small cell carcinoma of the lung after chemotherapy and radiation. Cancer 1988;61(11):2176-82.

47. de la Monte SM, Hutchins GM, Moore GW. Influence of age on the metastatic behavior of breast carcinoma. Hum Pathol 1988;19(5):529-34.

48. de la Monte SM, Gabuzda DH, Ho DD, Brown RH, Jr., Hedley-Whyte ET, Schooley RT, et al. Peripheral neuropathy in the acquired immunodeficiency syndrome. Ann Neurol 1988;23(5):485-92.

49. Ng SC, de la Monte SM, Conboy GL, Karns LR, Fishman MC. Cloning of human GAP-43: growth association and ischemic resurgence. Neuron 1988;1(2):133-9.

50. Pomerantz RJ, de la Monte SM, Donegan SP, Rota TR, Vogt MW, Craven DE, et al. Human immunodeficiency virus (HIV) infection of the uterine cervix. Ann Intern Med 1988;108(3):321-7.

51. de la Monte SM, Bour C, Radhakrishnan VV, Jupiter JB, Smith RJ, Hedley-Whyte ET. Effects of cyclosporin A and predegeneration on survival and regeneration of peripheral nerve allografts in rabbits. Surg Neurol 1988;29(2):95-100.

52. Ozturk M, de la Monte SM, Gross J, Wands JR. Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain. Proc Natl Acad Sci U S A 1989;86(2):419-23.

53. Cudkowicz M, De la Monte SM. Histogenesis and cell lineage analysis of medulloblastomas. J Neurol Sci 1989;94(1-3):221-9.

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54. de la Monte SM, Horowitz SA. Hemangioblastomas: clinical and histopathological factors correlated with recurrence. Neurosurgery 1989;25(5):695-8.

55. de la Monte SM, Wells SE, Hedley-Whyte T, Growdon JH. Neuropathological distinction between Parkinson's dementia and Parkinson's plus Alzheimer's disease. Ann Neurol 1989;26(3):309-20.

56. de la Monte SM. Uniform lineage of oligodendrogliomas. Am J Pathol 1989;135(3):529-40.

57. Bishop M, de la Monte SM. Dual lineage of astrocytomas. Am J Pathol 1989;135(3):517-27.

58. de la Monte SM, Hutchins GM, Moore GW. Racial differences in the etiology of dementia and frequency of Alzheimer lesions in the brain. J Natl Med Assoc 1989;81(6):644-52.

59. de la Monte SM. Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer's disease. Ann Neurol 1989;25(5):450-9.

60. Skolnik PR, Pomerantz RJ, de la Monte SM, Lee SF, Hsiung GD, Foos RY, et al. Dual infection of retina with human immunodeficiency virus type 1 and cytomegalovirus. Am J Ophthalmol 1989;107(4):361-72.

61. De la Monte SM, Federoff HJ, Ng SC, Grabczyk E, Fishman MC. GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. Brain Res Dev Brain Res 1989;46(2):161-8.

62. Ogilvy CS, Chapman PH, Gray M, de la Monte SM. Meningioangiomatosis in a patient without von Recklinghausen's disease. Case report. J Neurosurg 1989;70(3):483-5.

63. de la Monte SM, Ozturk M, Wands JR. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. J Clin Invest 1990;86(3):1004-13.

64. de la Monte SM, Hedley-Whyte ET. Small cerebral hemispheres in adults with Down's syndrome: contributions of developmental arrest and lesions of Alzheimer's disease. J Neuropathol Exp Neurol 1990;49(5):509-20.

65. Bernards A, de la Monte SM. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. Embo J 1990;9(7):2279-87.

66. Lee ME, de la Monte SM, Ng SC, Bloch KD, Quertermous T. Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest 1990;86(1):141-7.

67. de la Monte SM, Hsu FI, Hedley-Whyte ET, Kupsky W. Morphometric analysis of the human infant brain: effects of intraventricular hemorrhage and periventricular leukomalacia. J Child Neurol 1990;5(2):101-10.

68. de la Monte SM. Immunohistochemical diagnosis of nervous system neoplasms. Clin Lab Med 1990;10(1):151-78.

69. Maisonpierre PC, Le Beau MM, Espinosa R, 3rd, Ip NY, Belluscio L, de la Monte SM, et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 1991;10(3):558-68.

70. de la Monte SM, Wands JR. Neuronal thread protein over-expression in brains with Alzheimer's disease lesions. J Neurol Sci 1992;113(2):152-64.

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71. de la Monte SM, Volicer L, Hauser SL, Wands JR. Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 1992;32(6):733-42.

72. de la Monte SM, Spratt RA, Chong J, Ghanbari HA, Wands JR. Immunohistochemical and histopathologic correlates of Alzheimer's disease-associated Alz-50 immunoreactivity quantified in homogenates of cerebral tissue. Am J Pathol 1992;141(6):1459-69.

73. Miralbell R, Linggood RM, de la Monte S, Convery K, Munzenrider JE, Mirimanoff RO. The role of radiotherapy in the treatment of subtotally resected benign meningiomas. J Neurooncol 1992;13(2):157-64.

74. Chong JK, Cantrell L, Husain M, Riesing S, Miller BE, Wands J, et al. Automated microparticle enzyme immunoassay for neural thread protein in cerebrospinal fluid from Alzheimer's disease patients. J Clin Lab Anal 1992;6(6):379-83.

75. Bhavani K, Brown NV, Carlson RI, Rhoads D, Wands JR. The effect of ethanol and extracellular matrix on induction of p36 protein kinase substrate expression in rat hepatocytes. Biochem Biophys Res Commun 1993;196(3):1454-8.

76. Xu YY, Wands JR, de la Monte SM. Characterization of thread proteins expressed in neuroectodermal tumors. Cancer Res 1993;53(16):3823-9.

77. Hsu DW, Hakim F, Biller BM, de la Monte S, Zervas NT, Klibanski A, et al. Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence. J Neurosurg 1993;78(5):753-61.

78. de la Monte SM, Wands JR. Diagnostic utility of quantitating neurofilament-immunoreactive Alzheimer's disease lesions. J Histochem Cytochem 1994;42(12):1625-34.

79. Xu YY, Bhavani K, Wands JR, de la Monte SM. Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression. Biochem J 1995;310 (Pt 1):125-32.

80. Bhavani K, de la Monte S, Brown NV, Xu YY, Sasaki Y, Wands JR. Effect of ethanol on p36 protein kinase substrate and insulin receptor substrate 1 expression and tyrosyl phosphorylation in human hepatocellular carcinoma cells. Alcohol Clin Exp Res 1995;19(2):441-6.

81. de la Monte SM, Bhavani K, Xu YY, Puisieux A, Wands JR. Modulation of p36 gene expression in human neuronal cells. J Neurol Sci 1995;128(2):122-33.

82. Xu YY, Bhavani K, Wands JR, de la Monte SM. Insulin-induced differentiation and modulation of neuronal thread protein expression in primitive neuroectodermal tumor cells is linked to phosphorylation of insulin receptor substrate-1. J Mol Neurosci 1995;6(2):91-108.

83. de la Monte SM, Ng SC, Hsu DW. Aberrant GAP-43 gene expression in Alzheimer's disease. Am J Pathol 1995;147(4):934-46.

84. de la Monte SM, Quertermous T, Hong CC, Bloch KD. Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. J Histochem Cytochem 1995;43(2):203-9.

85. De La Monte SM, Carlson RI, Brown NV, Wands JR. Profiles of neuronal thread protein expression in Alzheimer's disease. J Neuropathol Exp Neurol 1996;55(10):1038-50.

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86. Lavaissiere L, Jia S, Nishiyama M, de la Monte S, Stern AM, Wands JR, et al. Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest 1996;98(6):1313-23.

87. de la Monte SM, Xu YY, Wands JR. Modulation of neuronal thread protein expression with neuritic sprouting: relevance to Alzheimer's disease. J Neurol Sci 1996;138(1-2):26-35.

88. de la Monte SM, Xu YY, Hutchins GM, Wands JR. Developmental patterns of neuronal thread protein gene expression in Down syndrome. J Neurol Sci 1996;135(2):118-25.

89. Bloch DB, de la Monte SM, Guigaouri P, Filippov A, Bloch KD. Identification and characterization of a leukocyte-specific component of the nuclear body. J Biol Chem 1996;271(46):29198-204.

90. de la Monte SM, Ghanbari K, Frey WH, Beheshti I, Averback P, Hauser SL, et al. Characterization of the AD7C-NTP cDNA expression in Alzheimer's disease and measurement of a 41-kD protein in cerebrospinal fluid. J Clin Invest 1997;100(12):3093-104.

91. Wands JR, Lavaissiere L, Moradpour D, de la Monte S, Mohr L, Nicolau C, et al. Immunological approach to hepatocellular carcinoma. J Viral Hepat 1997;4 Suppl 2:60-74.

92. Wands JR, Geissler M, Putlitz JZ, Blum H, von Weizsacker F, Mohr L, et al. Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection. J Gastroenterol Hepatol 1997;12(9-10):S354-69.

93. de la Monte SM, Sohn YK, Wands JR. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 1997;152(1):73-83.

94. de la Monte SM, Garner W, Wands JR. Neuronal thread protein gene modulation with cerebral infarction. J Cereb Blood Flow Metab 1997;17(6):623-35.

95. Geissler M, Wands G, Gesien A, de la Monte S, Bellet D, Wands JR. Genetic immunization with the free human chorionic gonadotropin beta subunit elicits cytotoxic T lymphocyte responses and protects against tumor formation in mice. Lab Invest 1997;76(6):859-71.

96. Paydarfar D, de la Monte SM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1997. A 50-year-old woman with multiple sclerosis and an enlarging frontal-lobe mass. N Engl J Med 1997;336(16):1163-71.

97. Bloch KD, Filippov G, Sanchez LS, Nakane M, de la Monte SM. Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period. Am J Physiol 1997;272(3 Pt 1):L400-6.

98. de la Monte SM, Bloch KD. Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease. Mol Chem Neuropathol 1997;30(1-2):139-59.

99. Etiene D, Kraft J, Ganju N, Gomez-Isla T, Gemelli B, Hyman BT, et al. Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease. J Alzheimers Dis 1998;1(2):119-134.

100. Banerjee K, Mohr L, Wands JR, de la Monte SM. Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells. Alcohol Clin Exp Res 1998;22(9):2093-101.

101. de la Monte SM, Sohn YK, Ganju N, Wands JR. P53- and CD95-associated apoptosis in neurodegenerative diseases. Lab Invest 1998;78(4):401-11.

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102. Brecher K, Hochberg FH, Louis DN, de la Monte S, Riskind P. Case report of unusual leukoencephalopathy preceding primary CNS lymphoma. J Neurol Neurosurg Psychiatry 1998;65(6):917-20.

103. Chiche JD, Schlutsmeyer SM, Bloch DB, de la Monte SM, Roberts JD, Jr., Filippov G, et al. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP. J Biol Chem 1998;273(51):34263-71.

104. Sanchez LS, de la Monte SM, Filippov G, Jones RC, Zapol WM, Bloch KD. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res 1998;43(2):163-8.

105. de la Monte SM, Ganju N, Wands JR. Microtiter immunocytochemical ELISA assay. Biotechniques 1999;26(6):1073-6, 1078.

106. de la Monte SM, Ganju N, Tanaka S, Banerjee K, Karl PJ, Brown NV, et al. Differential effects of ethanol on insulin-signaling through the insulin receptor substrate-1. Alcohol Clin Exp Res 1999;23(5):770-7.

107. Sohn YK, Ganju N, Bloch KD, Wands JR, de la Monte SM. Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases. J Neurol Sci 1999;162(2):133-51.

108. zu Putlitz J, Lanford RE, Carlson RI, Notvall L, de la Monte SM, Wands JR. Properties of monoclonal antibodies directed against hepatitis B virus polymerase protein. J Virol 1999;73(5):4188-96.

109. Primavera J, Lu BX, Riskind PJ, Iulian M, De La Monte SM. Brain Accumulation of Amyloid-beta in Non-Alzheimer Neurodegeneration. J Alzheimers Dis 1999;1(3):183-193.

110. de la Monte SM. Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration. J Neural Transm Suppl 1999;57:1-19.

111. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 1999;402(6762):615-22.

112. Bloch DB, Chiche JD, Orth D, de la Monte SM, Rosenzweig A, Bloch KD. Structural and functional heterogeneity of nuclear bodies. Mol Cell Biol 1999;19(6):4423-30.

113. de la Monte SM, Ganju N, Feroz N, Luong T, Banerjee K, Cannon J, et al. Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells. J Alzheimers Dis 2000;2(3-4):261-81.

114. de la Monte SM, Neely TR, Cannon J, Wands JR. Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons. Cell Mol Life Sci 2000;57(10):1471-81.

115. de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR. Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 2000;80(8):1323-35.

116. de la Monte SM, Lu BX, Sohn YK, Etienne D, Kraft J, Ganju N, et al. Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration. Neurobiol Aging 2000;21(2):309-19.

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117. Yoon SK, Mohr L, O'Riordan CR, Lachapelle A, Armentano D, Wands JR. Targeting a recombinant adenovirus vector to HCC cells using a bifunctional Fab-antibody conjugate. Biochem Biophys Res Commun 2000;272(2):497-504.

118. de la Monte SM, Ganju N, Banerjee K, Brown NV, Luong T, Wands JR. Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase. Alcohol Clin Exp Res 2000;24(5):716-26.

119. de la Monte SM, Sohn YK, Etienne D, Kraft J, Wands JR. Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease. Ann N Y Acad Sci 2000;903:61-71.

120. Ince N, de la Monte SM, Wands JR. Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation. Cancer Res 2000;60(5):1261-6.

121. Wenkel E, Thornton AF, Finkelstein D, Adams J, Lyons S, De La Monte S, et al. Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. Int J Radiat Oncol Biol Phys 2000;48(5):1363-70.

122. Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, et al. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem 2000;275(47):36847-51.

123. Bloch DB, Nakajima A, Gulick T, Chiche JD, Orth D, de La Monte SM, et al. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol 2000;20(16):6138-46.

124. de la Monte SM, Wands JR. The AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer's disease. J Alzheimers Dis 2001;3(3):345-353.

125. de la Monte SM, Neely TR, Cannon J, Wands JR. Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons. Cell Mol Life Sci 2001;58(12-13):1950-60.

126. Yoon SK, Armentano D, Wands JR, Mohr L. Adenovirus-mediated gene transfer to orthotopic hepatocellular carcinomas in athymic nude mice. Cancer Gene Ther 2001;8(8):573-9.

127. de la Monte SM, Wands JR. Neurodegeneration changes in primary central nervous system neurons transfected with the Alzheimer-associated neuronal thread protein gene. ���

128. de la Monte SM, Chen GJ, Rivera E, Wands JR. Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells. Cell Mol Life Sci 2003;60(12):2679-91.

129. Yeon JE, Califano S, Xu J, Wands JR, De La Monte SM. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology 2003;38(3):703-14.

130. Wiedmann M, Tamaki S, Silberman R, de la Monte SM, Cousens L, Wands JR. Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor. J Hepatol 2003;38(6):803-10.

131. Maeda T, Sepe P, Lahousse S, Tamaki S, Enjoji M, Wands JR, et al. Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells. J Hepatol 2003;38(5):615-22.

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132. Lahousse SA, Stopa EG, Mulberg AE, de la Monte SM. Reduced expression of the cystic fibrosis transmembrane conductance regulator gene in the hypothalamus of patients with Alzheimer's disease. J Alzheimers Dis 2003;5(6):455-62.

133. Chen GJ, Xu J, Lahousse SA, Caggiano NL, de la Monte SM. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J Alzheimers Dis 2003;5(3):209-28.

134. Xu J, Yeon JE, Chang H, Tison G, Chen GJ, Wands J, et al. Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem 2003;278(29):26929-37.

135. de la Monte SM, Chiche J, von dem Bussche A, Sanyal S, Lahousse SA, Janssens SP, et al. Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration. Lab Invest 2003;83(2):287-98.

136. de la Monte SM, Wands JR. Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling. J Alzheimers Dis 2004;6(3):231-42.

137. Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, et al. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology 2004;127(4):1110-22.

138. de la Monte SM, Wands JR. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease. J Alzheimers Dis 2005;7(1):45-61.

139. de la Monte SM, Xu XJ, Wands JR. Ethanol inhibits insulin expression and actions in the developing brain. Cell Mol Life Sci 2005;62(10):1131-45.

140. Merle P, Kim M, Herrmann M, Gupte A, Lefrancois L, Califano S, et al. Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. J Hepatol 2005;43(5):854-62.

141. Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005;8(3):247-68.

142. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis 2005;7(1):63-80.

143. Cantarini MC, de la Monte SM, Pang M, Tong M, D'Errico A, Trevisani F, et al. Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology 2006;44(2):446-57.

144. Chu J, Tong M, de la Monte SM. Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons. Acta Neuropathol. 2007 Jun;113(6):659-73.

145. Cohen AC, Tong M, Wands JR, de la Monte SM. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcohol Clin Exp Res. 2007 Sep;31(9):1558-73.

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146. de la Monte SM, Jhaveri A, Maron BA, Wands JR. Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery. J Neuropathol Exp Neurol. 2007 Apr;66(4):272-83.

147. Gundogan F, Elwood G, Greco D, Rubin LP, Pinar H, Carlson RI, et al. Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss. Hum Pathol. 2007 Jan;38(1):50-9.

148. He J, de la Monte S, Wands JR. Acute ethanol exposure inhibits insulin signaling in the liver. Hepatology. 2007 Dec;46(6):1791-800.

149. Ronis MJ, Wands JR, Badger TM, de la Monte SM, Lang CH, Calissendorff J. Alcohol-induced disruption of endocrine signaling. Alcohol Clin Exp Res. 2007 Aug;31(8):1269-85.

150. Wang J, de la Monte SM, Sabo E, Kethu S, Tavares R, Branda M, et al. Prognostic value of humbug gene overexpression in stage II colon cancer. Hum Pathol. 2007 Jan;38(1):17-25.

151. Xu J, Tong M, de la Monte SM. Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons. Acta Neuropathol. 2007 Jun;113(6):659-73.

152. Ain DL, Patrozou E, Feller E, de La Monte S, Mileno M. Intracerebral aspergillosis. Med Health R I. 2008 Jan;91(1):25-6.

153. Carter JJ, Tong M, Silbermann E, Lahousse SA, Ding FF, Longato L, et al. Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression. Acta Neuropathol. 2008 Sep;116(3):303-15.

154. de la Monte SM, Neusner A, Chu J, Lawton M. Nitrosamine link in the pathogenesis of diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease-hypothesis. J Alzheimers Dis. 2009;(In Press).

155. de la Monte SM, Tong M, Cohen AC, Sheedy D, Harper C, Wands JR. Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration. Alcohol Clin Exp Res. 2008 Sep;32(9):1630-44.

156. de la Monte SM, Wands JR. Alzheimer's disease is type 3 diabetes: Evidence reviewed. J Diabetes Sci Tech 2008;2(6):1101-13.

157. de la Monte SM, Yeon JE, Tong M, Longato L, Chaudhry R, Pang MY, et al. Insulin resistance in experimental alcohol-induced liver disease. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e477-86.

158. Gundogan F, Elwood G, Longato L, Tong M, Feijoo A, Carlson RI, et al. Impaired placentation in fetal alcohol syndrome. Placenta. 2008 Feb;29(2):148-57.

159. Longato L, de la Monte S, Califano S, Wands JR. Synergistic premalignant effects of chronic ethanol exposure and insulin receptor substrate-1 overexpression in liver. Hepatol Res. 2008 Sep;38(9):940-53.

160. Moroz N, Tong M, Longato L, Xu H, de la Monte SM. Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus. J Alzheimers Dis. 2008 Sep;15(1):29-44.

161. Cheng L, de la Monte S, Ma J, Hong J, Tong M, Cao W, et al. HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G135-43.

162. de la Monte SM. Insulin resistance and Alzheimer's disease. BMB Rep. 2009 Aug 31;42(8):475-81.

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163. de la Monte SM, Longato L, Tong M, DeNucci S, Wands JR. The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids. Int J Environ Res Public Health. 2009 Jul;6(7):2055-75.

164. de la Monte SM, Longato L, Tong M, Wands JR. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Curr Opin Investig Drugs. 2009 Oct;10(10):1049-60.

165. de la Monte SM, Neusner A, Chu J, Lawton M. Epidemiological Trends Strongly Suggest Exposures as Etiologic Agents in the Pathogenesis of Sporadic Alzheimer's Disease, Diabetes Mellitus, and Non-Alcoholic Steatohepatitis. J Alzheimers Dis. 2009 Apr 10.

166. de la Monte SM, Tong M. Mechanisms of Nitrosamine-Mediated Neurodegeneration: Potential Relevance to Sporadic Alzheimer's Disease. J Alzheimers Dis. 2009 Jun 19.

167. de la Monte SM, Tong M, Carlson RI, Carter JJ, Longato L, Silbermann E, et al. Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. Alcohol. 2009 May;43(3):225-40.

168. de la Monte SM, Wands JR. Insulin resistance and neurodegeneration: Type 2 versus Type 3 diabetes mellitus. Emerging Drugs and Targets for AD. 2009;1:235-54.

169. Giovannone B, Tsiaras WG, de la Monte S, Klysik J, Lautier C, Karashchuk G, et al. GIGYF2 Gene Disruption in Mice Results in Neurodegeneration and Altered Insulin-like Growth Factor Signaling. Hum Mol Genet. 2009 Sep 10.

170. Gundogan F, Elwood G, Mark P, Feijoo A, Longato L, Tong M, et al. Ethanol-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Placenta: Relevance to Pregnancy Loss. Alcohol Clin Exp Res. 2009 Dec 17.

171. Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, et al. Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology. 2009 Jun;49(6):1935-43.

172. Luu M, Sabo E, de la Monte SM, Greaves W, Wang J, Tavares R, et al. Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma. Hum Pathol. 2009 May;40(5):639-44.

173. Lyn-Cook LE, Jr., Lawton M, Tong M, Silbermann E, Longato L, Jiao P, et al. Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. J Alzheimers Dis. 2009 Apr;16(4):715-29.

174. Pang M, de la Monte SM, Longato L, Tong M, He J, Chaudhry R, et al. PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair. J Hepatol. 2009 Jun;50(6):1192-201.

175. Tong M, de la Monte SM. Mechanisms of ceramide-mediated neurodegeneration. J Alzheimers Dis. 2009 Apr;16(4):705-14.

176. Tong M, Dong M, de la Monte SM. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. J Alzheimers Dis. 2009 Mar;16(3):585-99.

177. Tong M, Neusner A, Longato L, Lawton M, Wands JR, de la Monte SM. Nitrosamine Exposure Causes Insulin Resistance Diseases: Relevance to Type 2 Diabetes Mellitus, Non-Alcoholic Steatohepatitis, and Alzheimer's Disease. J Alzheimers Dis. 2009 Jun 19.

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178. Brennan-Krohn T, Salloway S, Correia S, Dong M, de la Monte SM. Glial-vascular degeneration in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). J Alzheimers Dis. 2010;(In Press).

179. de la Monte SM, Tong M, Ng VA, Setshedi M, Longato L, Wands JR. Ceramide-mediated insulin resistance and impairment of cognitive-motor functions. J Alzheimers Dis. 2010:(In Press).

180. de la Monte SM, Wands JR. Role of central nervous system insulin resistance in fetal alcohol spectrum disorders. Fetal Alc Res. 2010:(In Press).

181. DeNucci S, Tong M, Longato L, Lawton M, Setshedi M, Carlson R, et al. Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. Gastroenterology Res Pract. 2010;(In Press).

182. He J, de la Monte SM, Wands JR. The p85-beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling. Biochem Biophys Res Commun. 2010;(In Press)

183. Lawton M, Tong M, Longato L, Wands JR, de la Monte SM. Aspartyl-(Asparaginyl) beta hydroxylase, hypoxia-inducible factor-1alpha, and notch cross-talk regulation of neuronal motility. Oxid Med Cell Long. 2010:(In Press).

184. Setshedi M, Wands JR, de la Monte SM. Acetaldehyde adducts in alcoholic liver disease. Oxid Med Cell Long. 2010;3(3):(In Press).

185. Tong M, Longato L, de la Monte SM. Early limited nitrosamine exposures exacerbate high fat diet-mediated type2 diabetes and neurodegeneration. BMC Endocr Disord. 2010 Mar 19;10(1):4.

186. Ma J, Altomare A, de la Monte SM, Tong M, Rieder F, Fiocchi C, et al. HCl-induced inflammatory mediators in esophageal mucosa increases migration and production of H2O2 by peripheral blood lelukocytes. Am J Physiol-GI. 2010;(In Press).

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PUBLISHED ABSTRACTS (Selected)

1. de la Monte SM, Gjedde A, Caronna JJ, Duffy TE, Plum F: Whole-brain blood flow and cerebral metabolic dysfunction during moderate and severe starvation. Neurology 1977; 27:398-399.

2. de la Monte SM: Hormone-dependent growth and differentiation of cultured brain in serum-free medium. Fed Proc 1979; 38:6163.

3. de la Monte SM, Moore GW, Hutchins GM: Non-random distribution of tumor metastases in the central nervous system. Fed Proc 1981; 41:336.

4. de la Monte SM, Hutchins GM, Moore GW: Congenital heart disease and peripheral neuroblastic tumors: Role of chronic hypoxic states in tumor induction. Circulation 1982; 66 (Suppl II):317.

5. de la Monte SM, Hutchins GM, Moore GW: Breast carcinoma and endocrine organ metastases. Lab Invest 1983; 48:19a.

6. de la Monte SM, Hutchins GM, Moore GW: Comparison of metastatic patterns of breast carcinoma between premenopausal and postmenopausal patients. Lab Invest 1983; 48:19a.

7. de la Monte SM, Hutchins GM, Moore GW: The role of estrogen and progesterone receptors in predicting metastatic behavior of breast carcinoma. Lab Invest 1983; 48:19a.

8. de la Monte SM, Hutchins GM, Gupta PK: Central nervous system pathology in Sjogren's syndrome: Polymorphous meningitis with "Sjogren's cells" in cerebrospinal fluid cytology. Fed Proc 1983;42:511.

9. Walton JA, de la Monte SM, Moore GW, Hutchins GM: Metastatic behavior of neuroblastoma. Fed Proc 1983;42:517.

10. de la Monte SM, Hutchins GM, Moore GW: Distributions of tumor metastases in the human CNS. Society for Neuroscience 1983;9:270.

11. Gasteiger EL, de la Monte SM: Spatial distribution of spinal nerve nets. The Physiologist 1983; 26: All0.

12. de la Monte SM, Castro F, Bonilla N, Gaskin de Urdaneta A, Hutchins GM: Systemic pathology of Venezuelan equine encephalitis in humans. Lab Invest 1984; 50:15a.

13. de la Monte SM, Hutchins GM, Moore GW: Effects of chemotherapy and radiation on the metastatic behavior of small cell carcinoma of the lung. Lab Invest 1984; 50:lSa.

14. de la Monte SM, Hutchins GM, Moore GW: Paraneoplastic syndromes correlate with metastatic behavior of small cell carcinoma of the lung. Fed Proc 1984;43:600.

15. Walton JA, de la Monte SM, Hutchins GM, Moore GW: Metastatic behavior of rhabdomyosarcomas. Fed Proc 1984;43:600.

16. Hutchins GM, de la Monte SM, Moore GW: Effects of anti-androgen therapy on the metastatic behavior of prostate cancer. Fed Proc 1984;43:600.

17. de la Monte SM, Hutchins GM, Moore GW: Early lesion of hyaline membrane disease of the newborn. Lab Invest 1984; 50:2p.

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18. de la Monte SM, Arcidi JM, Moore GW, Hutchins GM: Midzonal necrosis as a pattern of hepatocellular injury after shock. Lab Invest 1984; 50:15a.

19. de la Monte SM, Hutchins GM, Moore GW: Risk factors for different patterns of perinatal intracranial hemorrhage. Lab Invest 1985; 52:4p.

20. Hutchins GM, de la Monte SM, Moore GW: Pathologic distinction between bronchopulmonary dysplasia and the Wilson-Mikity syndrome. Lab Invest 1985; 52:5p.

21. Milner ME, de la Monte SM, Moore GW, Hutchins GM: Risk factors for developing and dying from necrotizing enterocolitis. Lab Invest 1985; 52:18a.

22. de la Monte SM, Moore GW, Monk MA, Hutchins GM: Risk factors for the development and rupture of intracranial berry aneurysms. Lab Invest 1985; 52:18a.

23. Mendelsohn G, de la Monte SM, Dunn JL, Yardley JH: Gastric carcinoid tumors and associated intestinal metaplasia. Lab Invest 1985; 52:43a.

24. de la Monte SM: Selective vulnerability of particular central nervous system regions to eastern equine encephalitis (EEE) virus infection in humans. J Neuropathol Exp Neurol 1985;358.

25. de la Monte SM, Horowitz SA, Larocque AA, Richardson EP Jr: Keyhole aqueduct syndrome. Lab Invest 1986; 54:15a.

26. de la Monte SM, Flickenger J, Linggood RM: Histopathologic features predicting recurrence of meningiomas. Lab Invest 1986; 54:16a.

27. de la Monte SM, Ho DD, Richardson EP Jr: Subacute encephalitis of the acquired immunodeficiency syndrome (AIDS). Lab Invest 1986; 54:16a.

28. de la Monte SM, Bour C, Sobel RA, Radhakrishnan VV, Jupiter JB, Smith RJ, Hedley-Whyte, ET: Influence of rejection and vascularization on regeneration of nerve grafts (NG) in rabbits. J Neuropathol Exp Neurol 1986;45:354.

29. de la Monte SM, Vonsattel JP, Hedley-Whyte ET, Ulcickas M, Richardson EP Jr: Global loss of cerebral cortex and white matter volume in Huntington's Disease. J Neuropathol Exp Neurol 1987;46:342.

30. Ulcickas ME, de la Monte SM: Morphometric analysis of the cerebrum in chronic alcoholics. J Neuropathol Exp Neurol 1987;46:340.

31. de la Monte SM, Ulcickas M, Hedley-Whyte ET: Disproportionate loss of cerebral white matter in patients with Alzheimer's Disease. Lab Invest 1987;57: 18A.

32. Eichhorn JH, de la Monte SM, Hedley-Whyte ET: Oligodendrogliomas: Clinicopathological correlations regarding recurrence. J Neuropathol Exp Neurol 1987;46:391.

33. de la Monte SM, Gabuzda DH, Ho DD, Brown RB, Hedley-Whyte ET, Sobel RA, Hirsch MS, Bhan AK: Peripheral neuropathy in the acquired immune deficiency syndrome. Lab Invest 1987;57:17A.

34. de la Monte SM, Hutchins GM, Moore GW: Racial differences in the etiology of dementia and the frequency of Alzheimer changes in the brain. Lab Invest 1987;57: 18A.

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35. Gray M, de la Monte SM: Meningioangiomatosis as a cause of seizures. Lab Invest 1987;57:2P.

36. de la Monte SM, Wells SE, Hedley-Whyte ET: Cerebral atrophy in Parkinson's disease (PD)-Effect of superimposed Alzheimer's Disease (AD+PD). Lab Invest 1988; 58:23A.

37. Horowitz SA, de la Monte SM: Hemangioblastomas: Factors correlated with recurrence or multiple tumors. Lab Invest 1988; 58:40A.

38. de la Monte SM, Phillips J: Uniform lineage of oligodendrogliomas. Lab Invest 1988;58:23A.

39. Bishop MP, de la Monte SM: Histogenesis of astrocytomas. Lab Invest 1988;58:10A. 40. de la Monte SM, Hsu FI, Kupsky W, Hedley-Whyte ET: Morphometric analysis of normal

and perinatal injured brains. Lab Invest 1988;58:4P. 41. de la Monte SM, Gabuzda DH: Immunopathology of subacute encephalitis of AIDS. Lab

Invest 1988;58:23A. 42. de la Monte SM, Gabuzda DH: Distribution of HIV antigen in the central and peripheral

nervous system. Lab Invest 1988;58:23A. 43. Hedley-Whyte ET, de la Monte SM, Wells SE, Growdon JH: Clinicopathological Analysis

of Cases in the Massachusetts General Hospital Alzheimer's Disease Brain Bank. J Neuropathol Exp Neurol 1988;47:343.

44. Wells SE, de la Monte SM, Hedley-Whyte ET, Growdon JH: Morphometric analysis of the cerebrum in Down's Syndrome and Alzheimer's Disease. J Neuropathol Exp Neurol 1988;47:380.

45. Cudkowicz ME, de la Monte SM: Neurofilament immunoreactivity in primitive neuroectodermal tumors (PNET). Lab Invest 1989;61:

46. de la Monte SM, Hedley-Whyte ET: Cerebral degeneration in Parkinson's disease: Effect of superimposed Alzheimer's disease (PD+AD). Lab Invest 1989; 61:

47. de la Monte SM, Resell H: Immunohistochemical demonstration of altered densities of GFAP+ and A2B5+ cells following perinatal brain injury. Lab Invest 1989; 61:.

48. de la Monte SM, Madsen JR: X Hapten immunoreactivity in oligodendrogliomas. Lab Invest 1989:61:.

49. de la Monte SM, Ng S-C, Hsu DW: Aberrant expression of GAP-43 in Alzheimer's disease. J Neuropathol Exp Neurol 1990; 49:319.

50. Donegan S.P., de la Monte S.M., Steger K.A., et al. HIV-1 infection of the lower female genital tract. Int Conf AIDS 1990; 6:268.

51. de la Monte SM: Glial cell expression of GAP-43 and aberrantly increased levels in Alzheimer's disease white matter. Lab Invest 1991;64:101A.

52. de la Monte SM, Wands JR: Neuronal thread protein: A potential marker for Alzheimer's disease. J Neuropathol Exp Neurol 1991;50:316.

53. de la Monte SM, Wands JR: Neuronal thread protein over-expression in brains with Alzheimer’s disease lesions. J Neuropathol Exp Neurol 1992;51:319.

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54. de la Monte SM, Growdon JH, Volicer L, Hauser SL, Wands JR: Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer's disease dementia. Neurobiol Aging 1992; 13, Suppl 1: S26.

55. de la Monte SM, Wands JR: Elevated neuronal thread protein levels in ventricular fluid and temporal cortex of Alzheimer's disease. Neurobiol Aging 1992; 13, Suppl 1: S26.

56.de la Monte SM, Dorfman DM, Brenner BM, Marsden PA. Tumor necrosis factor augments endothelin gene transcription and protein expression in the kidney; assessment with a transgenic mouse construct.

57. de la Monte SM, Wands JR. Isolation of a neuronal thread protein cDNA and characterization of the mRNAs expressed in neuroectodermal tumor cells and Alzheimer's disease brains. J Neuropathol Exp Neurol 1993; 52:265.

58. Xu Y-Y, Wands JR, de la Monte S. Thread protein expression in neuroectodermal tumor cell lines of central nervous system origin. J Neuropathol Exp Neurol 1993; 52:291.

59. de la Monte SM, Wands JR. Isolation of a neuronal thread protein cDNA and characterization of the mRNAs expressed in neuroectodermal tumor cells and Alzheimer's disease brains. J Neuropathol Exp Neurol 1993; 52:265.

60. Xu Y-Y, Wands JR, de la Monte SM. Thread protein expression in neuroectodermal tumor cell lines of central nervous system origin. J Neuropathol Exp Neurol 1993; 52: 291.

61. de la Monte SM, Marshall G, Welch J, Doe EJ, Reynolds S, Hutchins GM. The neuroanatomical substrate of Schizophrenia. Lab Invest 1994;70:138A.

62. de la Monte SM, Shaunessey K, Hutchins GM. Risk Factors for intrauterine intraventricular hemorrhage. Lab Invest 1994;70:

63. de la Monte SM, Haruta I, Brown NV, Carlson R, Rhoads DB, Wands JR. Ethanol-induced glyceraldehyde-3-phosphate dehydrogenase down-regulated gene expression and muted response to hormonal stimulation in primary rat hepatocyte cultures. Alcoholism Clin Exp Res 1994; 18:513.

64. de la Monte SM, Xu Y-Y, Wands JR. Aberrant expression of Alzheimer's disease neuronal thread proteins by ethanol treatment of CNS neuronal cell lines. Alcoholism Clin Exp Res 1994; 18:478

65. de la Monte SM, Bloch KD. Aberrant expression of the constitutive endothelial nitric oxide synthase (ceNOS) gene in Alzheimer's Disease. Lab Invest 1995; 72:135A

66. de la Monte SM, Krage R, , Zhao Y, Andrews D, Kurnick JT, Hutchins GM, Wands JR. Exocrine pancreatic enzyme gene expression in activated T lymphocytes: Possible role in the pathogenesis of multiple sclerosis. Lab Invest 1995; 72:135A

67. de la Monte SM, Xu Y-Y, Hutchins GM, Wands JR. Developmental patterns of neuronal thread protein expression in Down's syndrome. Lab Invest 1995; 72:135A

68. de la Monte SM, Bloch KD, Wands JR. Abnormal NTP and ceNOS gene expression correlates with dendritic pathology in AD. J Neuropathol Exp Neurol 1995; 54: 430.

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69. de la Monte SM, Sohn Y-K, Hutchins GM, Wands JR. Abnormal glial cell gene expression is an early and consistent feature of Alzheimer’s Disease. Lab Invest 1996;74;140A.

70. de la Monte SM, Wands JR. Increased apoptosis with p53 and Fas antigen up-regulation in Alzheimer’s disease. Lab Invest 1996;74:140A.

71. de la Monte SM, Wands JR. Probable distinct pathogenic mechanisms of subacute encephalopathy and subacute encephalitis in AIDS. Lab Invest 1996;74:140A.

72. de la Monte SM, Carlson RI, brown NV, Wands JR. Profiles of neuronal thread protein expression in Alzheimer’s disease. J Neuropathol Exp Neurol 1996;55:644.

73. de la Monte SM, Sohn Y-K, Wands JR, Bloch KD. Aberrant ceNOS expression correlates with neuritic sprouting and apoptosis in neurodegenerative diseases. Lab Invest 1997;76:149A.

74. de la Monte SM, Paul K, Wands JR. Reduced mitochondrial (MT) DNA content and MT Gene expression with apoptosis in AIDS encephalopathy. Lab Invest 1997;76:150A.

75. de la Monte SM, Iulian M, Wands JR, Cudkowicz M, Brown Jr. RH. Molecular neuropathology of SOD-1 mutant transgenic mice: evidence for neuritic sprouting and apoptosis. J Neuropathol Exp Neurol 1997;56:611.

76. Etiene D, Kraft J, Wands JR, Gomez-Isla T, Hyman BT, Hedley-Whyte Et, de la Monte SM. Cerebral infarction contributes to the heterogeneity of Alzheimer’s disease (AD). J Neuropathol Exp Neurol 1997;56:617.

77. Selcuki D, de la Monte SM. Spinal cord and neuromuscular pathology in AIDS. J Neuropathol Exp Neurol 1997;56:620.

78. Yoon S-K., Scaglioni, P.P., Mohr, L., Melegari, M.M., Armentano, D., de la Monte, S., Wands, J.R. Adenovirus mediated gene transfer and expression in mouse liver. Hepatology 1997; 26:633A.

79. de la Monte, S.M., Ganju, N., Tanaka, S., Brown, N.V., Wands, J.R. Ethanol inhibition of insulin-stimulated GAPDH expression is mediated through specific motifs of insulin receptor substrate-1. Hepatology 1997; 26:373A.

80. Mohr, L., Tanaka, S., de la Monte, S.M., Wands J.R. Proliferative response of hepatocytes to human insulin receptor substrate-1 (h-IRS-1) overexpression in the liver of transgenic mice. Hepatology 1997; 26:372A.

81. Ince, N., de la Monte, S.M., Friedman, P., Wands, J.R. Overexpression of HAAH (human aspartyl asparaginyl hydroxylase) in bile ducts is related to malignant transformation. Hepatology 1997; 26:362A.

82. Banerjee, K., Tanaka, S., Wands, J.R., de la Monte, S.M. Selective inhibition of tyrosyl phosphorylation of human insulin receptor substrate-1 on exposure to ethanol in HCC cells. Hepatology 1997; 26:353A.

83. Sohn Y-K, Bloch KD, Ganju N, Filippov G, Wands JR, de la Monte SM. Neuritic sprouting with aberrant expression of the nitric oxide synthase (NOS) 3 gene in neurodegenerative diseases. Lab Invest 1998;78:162A.

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84. Lu BX, Iulian M, Ganju N, de la Monte SM. bA4-Amyloid accumulation in brains with non-Alzheimer neurodegeneration. Lab Invest 1998;78:160A.

85. de la Monte SM, Sohn Y-K, Ganju N, Wands JR. p53- and CD95-associated apoptosis and sprouting with neurodegeneration. Lab Invest 1998;78:159A.

86. Ganju N, Wands JR, de la Monte SM. Increased apoptosis with up-regulation of the p53 gene in AD brains. J Neuropathol Exp Neurol 1998; 57(5):496.

87. de la Monte SM, Ghiche JD, Ganju N, Wands JR, Bloch KD. Nitric oxide synthase 3 mediates neuronal apoptosis through p53 gene modulation: relevance to AD. J Neuropathol Exp Neurol 1998; 57(5):496.

88. de la Monte SM, Ghanbari H, Ghanbari K, Wands JR. Role of AD7c-NTP in Alzheimer’s disease neurodegeneration. Neurobiol Aging 1999 (In press).

89. de la Monte SM, Luong T, Wands JR. Mitochondrial DNA damage as a novel mechanism of cell loss in Alzheimer’s disease. Lab Invest 1999 (In press)

90. de la Monte SM, Gemelli B, Brown NV, Wands JR. Aspartyl (Asparaginyl) b-hydroxylate (AAH) expression marks invasiveness of primary malignant CNS neoplasms. Lab Invest 1999 (In press).

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BOOK CHAPTERS AND N Engl J Med CPCs • Weiner H, de la Monte SM: Case Records of the Massachusetts General Hospital. Case

#25-1986. N Engl J Med 1986;314:1689-1700. • Picard E, de la Monte SM: Case Records of the Massachusetts General Hospital. Case

#21-1987. N Engl J Med 1987;316:1326-1335. • Winkler GF, de la Monte SM: Case Records of the Massachusetts General Hospital.

Case #32-1987. N Engl J Med 1987;317:366-375. • Jones JC, de la Monte SM: Case Records of the Massachusetts General Hospital. Case

#52-1990. N Engl J Med 1990; • Samuels M, de la Monte SM: Case Records of the Massachusetts General Hospital.

Case #36-1994. A 49-year old man with hypopituitarism, multifocal neurologic deficits, and an intracranial mass. N Engl J Med 1994; 331:861

• Paydarfar D, de la Monte SM Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1997. A 50-year-old woman with multiple sclerosis and an enlarging frontal lobe mass. N Engl J Med 1997 Apr 17;336(16):1163-71

• O'Leary DH, de la Monte S. Weekly Clinicopathological Exercises: Case 2-1998: A 50-Year-Old Woman with Increasing Headache and a Left Abducent-Nerve Palsy. N Engl J Med 1998 Jan 15;338(3):180-8

• Jones, JC, de la Monte SM Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1998. N Engl J Med 1998

• Vartanian, de la Monte SM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 1-1999. A 60-year old woman with positional headache. N Engl J Med 1999 (In press).

• de la Monte SM: Postmortem evaluation of neuromuscular diseases. In: AUTOPSY, Performance and Reporting. GM Hutchins, Ed., College of American Pathologists, Northfield, Illinois, 1990, pp. 99-106.

• de la Monte SM: Immunohistochemical diagnosis of nervous system neoplasms. In: Tumor Markers in Diagnostic Pathology. Clinics in Laboratory Medicine. 1990; 10(1); 151-178.

• de la Monte SM, Wands JR: Increased levels of neuronal thread protein in cerebral tissue and cerebrospinal fluid of patients with probable and confirmed Alzheimer's disease. In: Alzheimer's Disease: Advances in Clinical and Basic Research. B. Corain, K. Iqbal M. Nicolini, B. Winblad, H. Wisniewski, P. Zatta, Eds., John Wiley & Sons, Ltd. 1993, pp. 73-82.

• Wands, JR, Mohr, L, Banerjee K, Ganju N, Tanaka, S., de la Monte, SM. Ethanol and IRS-1 protein in the liver and brain. In: Effects of Ethanol on Signal Transduction de la Monte, SM, de la Torre, J. Molecular Mechanisms of Neurodegeneration. In: The Pathology of the Aging Nervous System. Ed. Duckett and de la Torre 2001.

• de la Monte, SM. Molecular Pathology of Alzheimer-Type Neurodegeneration in Down Syndrome. Nucleic Acids Research Monograph on Down Syndrome. 2000

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