SCIENTIFICS BASES AND INTERPRETATION

CE 0459

SUMMARY I . PRESENTATION II. PRINCIPLES OF FUNCTIONING: III.TECHNICAL SPECIFICATIONS OF ESG IV.BENEFITS OF THE ESG VI. SCIENTIFICS BASES

1. The quantum theory 2. Measurements of resistances of human body systems and organs 3. Colloidal Properties of a material 4. Perturbing foci and fields 5. Somaesthesia 6. Use of the principle of nuclear magnetic resonance in biology: 7. Information theory 8. Neurophysiology bases

VII. INDICATIONS OF ESG VIII.CONTRAINDICATIONS OF ESG: IX. INTERPRETATION OF RESULTS

1. Neurophysiological, neurofunctional and neurosciences bases 2. Statistical interpretation (15000 measurements) 3. Clinical protocol

APPENDICES Bibliography Clinical trials

I. PRESENTATION Electroscangraphy DDFAO is used to determine a delta function for the human body in the same way and using the same principles (measurement of electrical activity) as the electrocardiogram and electroencephalogram, which respectively determine cardiac and cerebral delta functions. The principle of ESG is to measure the body's electrical activity in 3D. It produces a synthesis based on quantum physics, neurophysiology and the neurosciences, using recognised medical bases to improve understanding of the human body's neurofunctional activity. By indicating the degree of activity of the main sub-cortical structures (hypothalamus, hypophysis and limbic system), the frontal lobes of the cortex, the immune system, neurovegetative system and all the organs, it can be used to provide a more global approach to medicine (psycho-neuro-immuno endocrine connection) and treatment monitoring. It is therefore an appropriate addition to your clinical observation equipment (examination time 2 minutes), enabling you to:

Provide rapid treatment for the patient, save time and organisation refine your diagnosis by prescribing further conventional examinations practice preventive infra-clinical medicine practice functional medicine (visualisation of the source)

take charge of the functional, psychological and pain components of all pathologies in synergy with conventional treatment.

II. PRINCIPLES OF FUNCTIONING:

Computerized screening and functional diagnosis is the result of a combination of works:

by quantum physics theorists

by R. Voll (Organometry, measurement of organ resistances and human body)

by T. Graham (the physiology of colloidal states of material)

by V. Schmidt and X. Pflaum (neuro-humoral regulation)

by H. Frôhlich (quantum supra-conductivity by coherent wave fields)

by I. Prigogine (coherent spatial organisation forming "the dissipative structures" of biological systems)

by application of mathematics and physics (Ohm’s law) to the functioning of the human body

by the knowledge acquired in neurophysiology, neurofunctional medicine and neurosciences

This combination of work was performed thanks to the power and progress of electronic and computerised techniques in analytical human biology.

The system introduces low intensity electrical signals (a continuous 1.28 V current) into the human body (this is totally painless and has no damaging effects) using the 6 electrodes referred to above.

The electronic flow emitted by the contractors in these "biologically active areas" disperses in every direction along the body and transforms into an ion flux in tissues, which indicates the return to the level of resistivity or conductibility of the areas traversed.

Greater or lesser conductibility of the tissues tested is amplified significantly in the presence of functional abnormalities (osteo-arthropathy, infectious foci, perturbers of the dental fields, reactogenic scarring, blood or lymphatic circulatory disorders, allergies, ionic disequilibria, intercellular transmissions etc.)

The work by Pflaum (1979, 1982) showed that months or years of functional disorders in humoral and neural regulation may be followed by the development of diseases. Every disease pre-exists its presentation and in terms of informational electrical transmission (R. Sheldrake, T. Moss, P. Mandell).

Any functional disorder therefore may anticipate the development of the corresponding organ disease by several months or years. This is the disorder measured by the ESG/ D.D.F.A.O. system

Application of Ohm's law to the biological system allows information to be obtained about areas of lesser resistance, normal resistant or high resistance, allowing the areas traversed to be diagnosed in the form of hypofunction, normo function or hyperfunction and the conductivity to be measured in the same areas, such that the test current sent separates electrons from ions, and thereby gives an indication of the aggregation state of the organic colloidal system.

The electrical field creates a polarised area on the skin between 2 electrodes, producing a bio-electric change and an action potential of the tissues cells.

Those ions generated for which carry a positive charge migrate towards the negative electrode and those which carry a negative charge towards the positive electrode. They are therefore distributed between the 2 electrodes.

The device intermittently reverses the polarity so that each electrode alternatively becomes the cathode and then the anode.

By applying Vincent's principle of electrotitrotion and bio-electronics, the system can therefore calculate the amounts of H+ and HC03- ions in the different tissues traversed, calculate their pH and therefore their acid or alkaline state. The electrodes are in contact with 6 areas of the skin which we shall call A, B, C, D, E and F.

The measurement programme includes 2 successive and inverse phase. When the current passes from A to B (from the anode to the cathode), and then from B to A, the electrodes send information to the measurement box

-about the resistance and conductibility of the tissues traversed.

-about the amount of H+ ions

The measurement box sends these data to the programme in the form of diagrams or graphs of different colours. The parallel port or USB and the programme reproduces these results in the form of different coloured diagrams or graphs.

- When the conductibility and number of H+ ions in the area traversed is normal, the colour is green: physiological function

- When the conductibility of the area traversed is raised (when the current passes quickly) and the number of H+ ions is increased (acid pH): the colour is yellow when the increase is moderate (moderate hyperfunction) and red when the increase is severe (severe hyperfunction).

When the conductibility of area traversed is low (the current passes slowly) and the number of H+ ions is reduced (basic pH): the colour is sky blue when the reduction is moderate (moderate hypofunction) and dark blue when the reduction is severe (severe hypofunction).

Each measurement between 2 points corresponds to the recording of a branch consisting of a certain number of organs. The measurement sequence for the branches is performed in the following order: 2, 10, 4, 11, 6, 14, 7, 16, 17, 19, 22, 1, 9, 3, 12, 5, 13, 8, 15, 18, 20 and 21.

By crossed analysis (common organs and systems in the different branches) of these 22 measurements of conductibility and H+ ions, the programme can target areas, organs and systems which are functioning physiologically or are in hypo or hyper function.

E F

C D

B A

III.TECHNICAL SPECIFICATIONS OF DDFAO

Technical data’s

The DDFAO device converts to numerical form signals in order to obtain an examination by electric stimulation of biologically active points of the skin. A tension of 1.28 V is applied on 6 electrodes.

2 to the hand 2 to the feet 2 to the front

The results are obtained by the intermediary of 7 measurements canals. The device works in connection with a computer of the type PC/AT through USB connection. The electricity (5V) for the measurement is furnished by the USB connected to a computer.

Technical Specifications :

Functioning speed (per second) 50000 Tension of the electrodes while functioning

1.28 V

Dimensions in mm 225/165/40

Weight in kg 1.5 USB connection 5 V

Value scale of colors used( international chromatography ) :

+60 / +100 Greatly increased bio conductivity .+20 /+ 60 Increased bio conductivity -20 / +20 Normal bio conductivity - 20 / –60 Reduced bio conductivity -60 / –100 Greatly Reduced bio conductivity

pH TISSUE

pH INTRACELLULAR

pH BLOOD

RESISTANCE KOhm

POURCENTAGE (%)

7,15 6,9 7,4 100 0 7,14 6,89 7,41 84 10 7,13 6,88 7,42 68 20 7,08 6,83 7,47 55,5 30 7,03 6,78 7,52 43 40 6,98 6,73 7,57 35 50 6,93 6,68 7,62 27 60 6,88 6,63 7,67 19 70 6,83 6,58 7,72 11 80 6,78 6,515 7,76 6,5 90 6,73 6,45 7,8 2 100

7,57 7,28 6,98 1000 -100 7,52 7,25 7,03 955 -90 7,47 7,22 7,08910 -80 7,42 7,17 7,13 690 -70 7,37 7,12 7,18 470 -60 7,32 7,07 7,23 430 -50 7,27 7,02 7,28 390 -40 7,22 6,97 7,33 270 -30 7,17 6,92 7,38 150 -20 7,16 6,91 7,39 125 -10

Correspondences between Resistance and pH

IV. BENEFITS OF THE DDFAO The DDFAO System ( Computerized Screening and Functional Diagnosis) is the result of the progress achieved in data processing and in biotechnology, of the application of mathematics and physics ( Ohm’s Law) to the human body and of the knowledge acquired in neurophysiology, in neurofunctional medicine and in neurosciences. -possibility to visualise the body’s function in the correct chronobiology of an individual -predictive medicine -structural diseases -dynamic analysis -electroscangram of the entire body (ESG) -follow up of therapies and control of treatments Through the analysis of organic tissue, of the body’s systems and of the segmental innervations of the skin, it allows the evaluation of the quality of homeostasis of a given organism according to its regulatory capabilities and its capacity to adapt to its environment. -low cost medical system -non-invasive method of investigation -essential too that complements clinical observation -necessary time for measurement: 2 minutes The originality of this system comes from proposing a new way of reading the purely biophysical aspects of the body’s functioning but also from the establishment of a direct link between neuro-functional regulation and informational regulation which leads to an open system of regulation which integrates the conventional approach of disease and a biophysical approach which is quantifiable. Thus it opens the way for new research but offers already a mechanism of understanding which was unknown until now because it was not measurable ( acupuncture, homeopathy, osteopathy…) .At the dawn of the 21st century and alongside functional MRI , Magnetoencephalophy, genetic engineering and space medicine, the DDFAO should be among the leaders in biotechnology with the added advantage that it can be used in the medical office. The DDFAO will change the daily practice for doctors ,eliminating the barriers between conventional medical care and alternative medicine. The indications are shown visually and alternative medicine possesses finally a diagnostic tool and a follow up of therapies. The Synergy between these disciplines will allow the patient to have the optimum treatment of lesions ,as well as standpoint functioning . The dysfunction preceding the lesion ,the DDFAO associated to the genomic profiles , will allow the doctor to practice “predictive medicine” which will certainly be the medicine of the XXIst century.

V.RESULTS ANALYSIS After the recording of the data of the patient, the ESG/ DDFAO proposes to doctors to visualize a body of data that shows the functional capacity and the homeostasis of the patient. The results present themselves under the following form: 1.Reconstitution pictures : Vertebral column report or Vertebral ESG (visualization of the rachis) Integral analysis or Organic ESG : an organic report (96 individualized zones ) Neurovegetative or autonomic system ESG report Segmental innervations ESG report Dental disruptive field ESG report Lymph node chain ESG report (value of the principals ganglions) 2.Linear or circular graphs allowing the analysis regulatory systems of the organism 3.A report of all bioelectrical points integrated in virtual circuits: Main ESG meridians Paradox ESG meridians Muscular ESG tendon meridians Lo ESG points Assistance for choice of acupuncture points on body External and internal face electroauriculogram Bioelectrical regulation centers 4. An aid to the therapeutic decision: Biophysical treatments Products BRC Medibio are a homeopathy and acupuncture rational modernizations Classical homeopathy Osteopathy Chemical substances acting on the physical structures Phytotherapy Trace elements 5.Interpretation Functional Psychological or behavioral 6.Personalized diet and micro nutrition 7. Results analysis reserved for the doctor 8.Information for the patient 9.Supplementary examinations 10.The doctor’s report for the patient

VI. SCIENTIFICS BASES

1- The quantum theory

This science of the infinitesimally small, of subatomic particles, combines 2 major lines of medical thinking: eastern energy and western physiology.

The Russians, at the watershed of the eastern and western cultures, were pioneers in this field. Nicolaï G. Bassov and Alexandre Prokhorov received the Nobel Prize for physics in 1964 for the discovery of Maser (the Precursor of Laser) in the 50s.

Quantum theory is quintessential chemistry, physics and biology, placing the subatomic parts of material at the centre of the energy cybernetics of our homeostasis.

Since the start of the 20th century, we owe our knowledge of the structure of the atom to the works of the British physicist Ernest Rutherford.

Formulated by Max Planck in 1900, the concept of quantum action has been developed from 1926 to the modern day by Louis de Broglie, Niels Bohr, Wolfgang Pauli, Werner Heisenberg, Erwin Schrödinger, Paul Dirac and many others. This elementary particle, the photon is both a corpuscle and an energy quantum, and allows information coherence from the whole body to be maintained in a homeostatic hologram.

When electrons are hit by energy quanta, (photons), they change gravitational orbits, performing what is called "quantum leaps", and absorbing or emitting electromagnetic radiation. Much research has been performed in this field

" Georges Lakhovsky (cellular oscillating circuits, 1939 (1)

" Harold Burr ("Living cellular fields", 1945 (2)

" Erwin Schrödinger (Nobel Prize for quantum mechanics in 1933, "open systems and

entropy", 1945(3)

" Herbert Frolich (quantum supra-conductivity phenomena, 1952, by dipolar oscillations of

cell membranes,confirmed in 1974 by Soviet researchers (4), the concept of intercellular and inter-organ language thanks to coherent wave fields in 1988 (5)

" In 1970, at the Kharkov State University, N.P. Zalyubovskaya gave a first presentation on

the effects of bio-resonances of millimetre waves. In the same period, in Canada, S.I. Webb conducted identical research, followed slightly later by Gründler and Kelmann in Germany, and by others in other countries.

" Ilya Prigogine (Nobel prize winner for chemistry, 1977), for his research into the

"dissipative structures" which through their coherent spatial organisation, could propagate throughout the entire biological system, which remains in a permanent state of change (6)

" In 1982, scientists from the Kiev State University: Ye. A. Andreyev, M.U. Bely and S.P.

Sit'ko, discovered "the existence of fundamental frequencies which are characteristic of the human body" (7), by analysing information obtained from extraordinary "opposing effects" observed by the physicists I.S. Cherkasov and S.V. Nedzvetsky from Odessa. Experimental studies on the action of millimetre electromagnetic wave resonance on the human body firstly opened new diagnostic and therapeutic opportunities and secondly gave birth to a new science: the physics of the living being.

" Fritz Albert Popp (1989, coherent electromagnetic Laser type emissions, by cellular DNA

provide the communication for cells and tissues) (8). Closer to home, it has been shown that cyto-skeletal microtubules act as a guide for millimetre electromagnetic waves, which provide the resonance and coherence for all biological entities at frequencies of 1013 Hz and their harmonics. (9)

In terms of the concept of dissipative structures, and since the initial work by Lashley and Pribram showing the network functioning of neuronal populations, a model of holographic optical quanta was proposed by Pribram, in 1991, in order to model the brain (10).

In 1987 and 1993, Davidov, introduced the concept of solitons to explain metabolic energy transport mechanisms, acting through excitation of molecular chains. (11).

Freeman (l 996, 2000) observed that networks of neurones functioned in a manner which was synchronised both in phase and in amplitude (12, 13).

Ricciardi, in 1967 and Umezawa in 1976, had already biult up the quantum model of the brain, accepting this hypothesis (14).

At the end of 1997, progress in millimetre wave measurement machines (with a sensitivity in the region of 0.5x10-22 W/Hz) made it possible to record human millimetre radiation (15). The dissipative quantum model of the brain was applied and confirmed for the neuronal networks by Pessa in 1999 (16).

In 2000, Eléonora Alfinito confirmed the quantum field theory, observing that dipolar quantum waves had varying frequencies in time and space, both for memory effects and for localised cerebral activities (17). This concept of the "living being" was considered by Sit'ko to be the 4th constituent of the quantum organisation of nature, after the molecule, atom and nucleus (18).

It has been established that a strong electric field ( # 105 V/cm) exists at the surface of each living cell membrane. Considering that the physical properties of membranes allow these to oscillate at frequencies of 1010 to 1011 Hz (i.e. millimetre waves), Sit'ko concluded that each cell of each living organisms could be considered to be a source of an electromagnetic pump. Specialists at the Scientific Research Centre for Quantum Medicine "VIDHUK" of the Ukraine Ministry of Health, used very high sensitivity radiometric measurement systems to determine the radio-electric properties of the human body:

- irradiation tends towards a constant level for each specific organism - For different people, the levels of radiation may differ by 2 or 3 values - The potency of the radiation depends on the functional state of the body, the type of life

and nutrition (19). References

1) G. Lakhovsky : « Le secret de la vie », Ed. Gauthier-Villars, Paris 1928

2) Harold Saxton Burr : « Blue Print for immortality - The electric pattern of life", Ed. C.W. Daniel Cy Ltd, Saffron Walden, England

3) Erwin Schrödinger: " What is life? ", Cambridge University Press, London 1945

4) N.D. Deryatkov, Soviet Physics USPEKHI 16, 568 - 1974

5) H. Frohlich: " Biological Coherence and Response to External Stimuli Ed. Springer Heidelberg, 1988

6) I. Prigogine et I. Stengers : « La Nouvelle Alliance », Ed. Gallimard, 1979

7) Andreyev Ye. A., Bely M. U., Sit'ko S. P. "'Manifestation of characteristic eigenfrequencies of human organism". Application

for the Discovery to the Committee of Inventions and Discovery at the Council of Ministers of the USSR. 32-OT- 1 0609.b May 22, 1982 (in Russian)

8) F. A. Popp, "Biologie de la Lumière", Ed. Pietteur, Liège, 1989

9) Golant MB. : Acoustico-electric waves in cell membranes of living organisms - a key problem for understanding of mm waves interaction with living orgamisms. In: Deviatkov N.D. and Betskii O.V. Ed. Seven plus, Moscow, 1994

10) K.H. Pribram, Brain and perception, Lawrence Erlbaum, New Jersey, 1991

11) A.S. Davydov, V.N. Ermakov, Physica, D28,168,1987 12)13). Freeman, Intem. J. of Neural Systems, 7, 473 (1996)

14) LM. Ricciardi and H. Umezawa, Kibemetic 4, 44 (1967)

15) "Physics of the Alive", Vol. 6, 1, (1998)

16) E. Pessa and G. Vitiello, Bloelectrochemistry and Bioenergetics 48, 339 (1999)

17) C.I.J. Stuart, Y. Takahashi and H. Umezawa, J. Theor. Biol. 71, 605 (1978)

18) "Physics of the Alive", (1993, 1994, 1995)-, (Ed. by S. Sit'ko)

19) Sit'ko S.P., Yanenko A.F. Direct registration of the non equilibnium electromagnetic radiation of a human body in mm-range. Physics of the Alive. - V.5, N02 - 1997. P. 60

20) H. Rossman und F. A. Popp : Statistik der Elektroakupunktur nach Voll 1 Arztzeitschrift fùr Natur Heil Verfahren, Jan. 1986, 51-59; and Sept. 1986, 623-630

2 - Measurements of resistances of human body systems and organs

In 1954, Dr Rheinhold Voll (1909-1990), a German physicist from Plochingen, measured the human organ and body system resistance by electro-acupuncture (Voll organometer) to the passage of a continuous 1.28 V current (minimal voltage to be applied between 2 electrodes in order to obtain passage of a current without changing biological systems).

Several thousands of patients were tested in this way. Voll's works were correlated and published in 1986 by Fritz Albert Popp, a world-renowned expert at the Kaiserlautern Biophysics Centre in Germany (20). Voll was able to measure the resistances of organs and systems in human beings.

The resistances ranged between 1000 and 2 kiloohms. A healthy individual in homeostatic equilibrium had values of 100 k ohms per measurement branch, with limits of between 140 and 94 k ohms.

Any increase in resistances indicates a hypo-reactivity or hypofunctioning (greater than 140 k ohms) process, and any fall in resistances indicated either an irritative process (between 94 and 71 k ohms), or either an inflammatory process or intoxication (resistances less than 70 k ohms).

3 - Colloidal Properties of a material

After T. Graham discovered a new state of a material in 1861: the colloidal state, an intermediary between the mineral and organic, allowing cells to keep their properties in a common medium, optical, physical and chemical refinement allowed the observation to be made that the entire human body, except for the integument, consists of infinitely small particles which were constantly moving and electrically charged, maintained in suspension, and all forming the "colloidal state".

The essential characteristics of this "colloidal state" is that the perpetual movement of these unicellular particles (an agglomerate of similar molecules of 0.001 to 0.3 µn, called micelles).

The agitation was due to electrical charges which these particles carried and to the action of the terestial magnetic field (W. Krauss, 1979) and to movements of cellular centrioles (M. Bornens).

If these electrified micelles lost their electrical charge, they stopped moving and precipitated. Similarly, if their movement was slowed down or stopped, the micelles lost their electric charge and precipitated (obvious crystallisation of a blood drop, R. Steiner).

As a result of all this, it is essential to constantly maintain this dual physical factor: movements-charge and charge-movements of micelles, defines the permanent biological colloidal state and any damage to one or other of these factors causes them to precipitate.

Any biological material taken from a clinically and biologically healthy body is a in a preserved colloidal state, and vice versa. The colloidal state corresponds to a precise movement of eletronic charge within the living material, both in terms of the ions emitted and those which are received.

The quality of the intra- and extracellular water (which makes shorter or longer hydrostatic bonds: monomers, dimers, trimers etc. up to 7 molecules may be bound together, studies by Damadian), both increases and amplifies the quality of the electrical signal.

This results in one major law: all colloidal systems are not living but all living systems are colloidal; electronic charges give the structure to the material, failing which the material is reduced to the state of its constitutent materials.

4 - Perturbing foci and fields

Studies by X. Pflaum (between 1979 and 1982) and by V. Schmidt on neuro-humoral regulation, and by R. Sheldrake, T. Moss and P. Mandell demonstrated that any pathological

process is preceded to a greater or larger extent by neuro-functional disequilibrium and loco-regional electrical constants.

5 - Measurement of biological microcurrents

The research bio-electronics work by L.C. Vincent allowed measurement techniques for biological micro currents to be established. This method has been automated and computerised by the German company Med-tronik.

It is based on the concept "of electrotitrotion". The electrical field created by a generator between 2 skin electrodes, alternatively anode and then cathode, induces polarisation of the biological volume traversed by the field, the electron flow transforming into an ion current.

By applying Ohm's law, the system may therefore calculate the amounts of H+ ions (acid) and basic ions (HCOO, performic acid) in the different tissues of the areas traversed.

The redox processes which permanently regulate all cell mechanisms for membrane equilibration, ion exchange, enzyme activity, osmotic and oncotic pressures, rH2 and pH and at the end of the day, the human electrical field.

They obey very strict laws and constraints. The Vincent bio-electronic allows pH, resistivities and redox (rH2) potentials of blood, urine and saliva to be analysed and biological micro currents to be measured.

6 - Somaesthesia

In addition to the clearly identified sensory organs such as eyes and ears, the body has receptors which are sensitive to tissue mechanical stimulation in almost all of its tissues. Information obtained from all of these receptors form the stomato visceral sensitivity and is divided into a somatic sensitivity or somaesthesia (either superficial or deep) (the system inervating the skin, joints, ligaments and tendons) and visceral sensitivity (the system inervating the viscera) (fig. 6.1). Somaesthesia represents four major modalities: mechanical sensitivity (touch, vibration etc.), thermal sensitivity, chemical sensitivity and pain. Chemo reception, which is involved mostly in visceral sensitivity, is linked to the autonomic nervous system.

7 - Use of the principle of nuclear magnetic resonance in biology:

Dr Raymond Damadian, a mathematician and bio-physicist from the New York State University Medical Center, studied the magnetic resonance of water molecule protons in living cells (proton relaxation time, linked to H+/OH- hydrostatic bonds). He showed that these protons, when they formed part of a cancer cell, had a different relaxation time to protons from healthy tissues. All healthy tissues have times of between 0.26 and 0.90 seconds, whereas the same tissues when diseased by tumour contain less bound water, which requires 1 and 1.5 seconds to delete the orientation effects of the resistant field. By a mechanical comparison, it may be considered that application of NMR involves measuring the elasticity of the molecule. Dr R. Damadian came to the conclusion that the water molecules in cancerous tissue behaved differently to water molecules in normal tissue. In his opinion, water was the major component of all cells and water molecules formed dipoles, i.e. groups formed by two electrical or magnetic charges, which were equal and of opposite polarity. In a healthy cell, the dipoles align along the electrical fields created by ions (atoms or groups of atoms carrying an electrical charge) within the cells, in an order which corresponds to the cell structure. The electrical charges are perturbed and the structure of the cell is disorganised in the cancer cell, the centrioles which were perpendicular become parallel (explaining the loss in tempero-spatial positioning of the cell). The work by Dr Damadian completely confirmed the bio-electronic explanation for the origin of cancerous cells.

8 - Information theory

This is based on the following work:

" Morpho-genetic fields and information theory by R. Sheldrake " The biology of light by A.F. Popp " The colloidal theory by T.Graham " Calculation of frequencies at an organic level by Sit'ko " Cell exchanges induce a potential difference at the level of the membrane

These studies show the existence of an intercellular language within the body, coding of information in electromagnetic form at the level of the cell being the key to medicine for the future

9 – Some Neurophysiology principles

A review of the fundamental principles of neurophysiology will enable you to rapidly interpret the ESG Homeostasis Homeostasis is the natural capacity of our body to maintain a dynamic state of equilibrium of our internal environment. Homeostasis is dependent on cortical and sub-cortical structures (the capacity for functional regulation of homeostasis) and on genetic polymorphism (the capacity for genetic regulation of homeostasis) ESG allows the state of health of the subject (functional delta) to be established with respect to its ability to maintain correct homeostasis. Our brain is above all programmed to ensure survival of the individual at all costs. Amongst other things this survival is based on respect of the equilibrium of these constants of our internal environment. However, all systems and organs contribute to maintaining homeostasis. This dynamic regulation is subject to variations which remain within a physiological delta value. The ESG images may therefore vary depending on chronobiology and according to the circumstances at the time of measurement, as do all laboratory analyses, the electrocardiogram or electroencephalogram. These variations must however be maintained within a physiological delta value ESG and brain’s structure The ESG records values of neuronal excitability and metabolic production of the following cortical and sub-cortical structures: Frontal lobes: which are the place where thought is constructed The hypophysis: production from which determines almost all of the hormonal system The hypothalamus represents 1% of the total weight of the brain i.e. 4 grams. However it controls a large part of our major functions: Blood pressure Hunger/thirst regulation The autonomic nervous system Body temperature The endocrine system, through releasing factors from the hypothalamus By showing the extent of metabolic production, ESG plays a key role in neurofunctional diagnosis ESG also allows the level of neuronal excitability of the limbic system to be estimated. The limbic system influences our behaviour and the handling of our emotions. As we know that emotions influence the immune system, the endocrine system and the autonomic nervous system, we can understand the importance of this measurement. The limbic system also controls our medium term memory and our learning memory. In addition it plays a role in triggering dermatological problems

The autonomic nervous system : dysfunctions of the autonomic nervous system are factors which aggravate many diseases (diabetes, cardiovascular diseases). They may also be sufficient to explain many dysfunctions (constipation, gastrointestinal problems, stress etc.) ESG and immunity Immunity : ESG also records the level of T lymphocytes circulating in the body. T lymphocytes form one of the bases of the immune system, as antibodies released by B lymphocytes require the presence of T lymphocytes. T lymphocytes also give rise to NK (Natural Killer) cells which are necessary for the removal of organisms and cancer cells Connection neuro- psycho- endocrino-immune (image I and II) The image I helps us to understand the interrelationship or connection between the 3 body systems: The central nervous system, with which is associated the autonomic nervous system The endocrine system The immune system This connection is achieved through molecules, the neuropeptides, neuromediators and cytokines. The relationships of this organisation are essential for the neurofunctional interpretation of ESG demonstrates the importance of the endocrine system and the effects of existing modulation or feedback The stress Discovered by PR Seyle, the implications of stress in medical terms is still a current topic. Stress is necessary for life, although its persistence is responsible for dysfunctions and factors which aggravate many diseases. (image III) In addition, as a result of feedback from persistent stress, we can better understand how inflammation, for example gastro-intestinal, can lead to a fall in immunity or a depressive state These 2 curves demonstrate the inverse relationship between blood cortisol levels and the number of plasma T lymphocytes.(image IV) From this curve it is clear that a state of stress maintained by infection, allergy, a virus or a psychological problem will have repercussions on immunity. Sanguineous pH and tissue pH (image V ) Finally, you should remember that blood and tissue pH behave inversely Acidosis corresponds to basic tissues (blue colour on the ESG)

Image I

CCeennttrraall NNeerrvvoouuss SSyysstteemm

Left Cortex Right Cortex

reticular GlucocorticoïdsTTHHAALLAAMMUUSSlimbic SystemAutonomic System

HHYYPPOOTTHHAALLAAMMUUSS ADHSerotoninDopamin

SS MSH GRF CRF LFR TRF

Médulloadrenal HHYYPPOOPPHHYYSSIISS Corticoadrenal Catécholamines

immune System endocrine System Image II

No cognitif stimuli (bacteries,virus,toxins)

cognitif stimuli (emotionnal stress)

MSHLymphocytes Hypothalamus

CRH CRH

Macrophages Hypophysis IL-1ACTH TSH FSH

Lymphocytes B

Adrenal ACTH

Glucocorticoïds

Image IV

T LYMPHOCYTES

8 H 11H 16H 22H

CORTISOL PLASMA

8h

Image III

Stress Bacteries, virus,allergie,

intoxication, psychological conflict ,

Hypothalamus

Hypophysis Autonomic systemLimbic S.

CorticoadrenalImmune S. Médulloadrenal

CortisolCatécholamines

Glucocorticoïdspersistent Stress

vigilance

feedback Effects Come back to normal

Image V

TISSUES ACID

Inversion Interfaces

acid /alkalin

Reduction /oxydation

Foods

Drinks Medicine

ALKALIN

Sanguineous URINE

ACID

VII. INDICATIONS FOR ESG / DDFAO General medicine: Essential tool complementary to clinical observation to determine:

Whether homeostasis is respected (internal media constants) and if it is not to prescribe further examinations (screening) Functional diseases, to determine the cause and origin The functional complications of lesions Recorded cure for all diseases

Gynaecology By visualising the psychoneuro-endocrino-immune connection

To understand the causes of hypofertility or sterility To monitor difficult pregnancies

Cardiology The inflammatory region revealed by the DDFAO can help:

Evaluate cardiovascular risk Initiate action to prevent the pathology Monitor treatment of cardiovascular diseases Treat aggravating factors (cortisol , sympathetic system, psychology, immunity….)

ENT Distinguish between allergy and chronic inflammation Monitor treatment

Surgery Estimate the body's recovery potential before surgery and thereby reduce the risk of

neucosomial diseases Reduce stress before surgery Improve healing

Anti-age medicine ESG provides a view of inflammation and tissue ischemia which significantly increases entropy Endocrinology Note the psychoneuro-endocrino-immune connection and therapeutic monitoring of replacement therapy Psychology and psychiatry Note the psychoneuro-endocrino-immune connection and acquire greater understanding of the origin of psychiatric pathologies or behaviour Nutritionists Note the psychoneuro-endocrino-immune connection and acquire greater understanding of the origin of obesity or anorexia. Oncology

Determine the oxidizing stress in a basic medium, which promotes genetic damage responsible for initiating cancer, and introduce prevention at this stage View the dysfunction caused by the cancerous lesion and restore homeostasis to

improve prognosis Therapeutic monitoring

Gastro-enterology Note the psychoneuro-endocrino-immune connection and acquire greater understanding of the origin of digestive problems (constipation, mucosal hyperpermeability ….) Sports medicine Practicing sport at a high level requires an optimal state of homeostatic balance Visualising the levels of stress, oxygenation at muscle level and the athlete's psychological condition will influence his or her performance. Dermatology Skin diseases often have psychological, endocrine, immune system, allergic or hepatic origins….visualisation of the psychoneuro-endocrino-immune connection is used to determine the origin of pathologies and appropriate treatment. Pain-relief medicine Practicing neurofunctional auricular acupuncture helps reduce almost all types of pain. Professor Alimi relieves Gustave Roussy cancer sufferers using this method and a publication proves that this technique has given results where morphine was ineffective. Homeopathy: Homeopathy acts without drugs, using the transmission of low frequency electromagnetic waves. DDFAO which records bioconductivity, is used to recommend the most suitable bioelectronic treatment. Acupuncture Acupuncture, created by the Chinese empirically, 5000 years ago, was used to restore the body's balance (yin /yang), which neurophysiologists call homeostasis. It is precisely these variations in balance and connections which DDFAO displays. An electrical measurement of all the meridians, taking chronobiology into account, is also taken without using subjective methods such as pulse-taking or the condition of the tongue. VIII. CONTRAINDICATIONS OF DDFAO:

Cardiac pacemaker wearers Dermatological lesions in contact with the electrodes

Amputation of member

Pregnant women: the examination is not dangerous, but the results could be incorrect

due to the presence of the baby

IX. INTERPRETATION OF RESULTS Interpretation is based on neurophysiological, neurofunctional and neuroscientific aspects and inductive statistics (using more than 15000 measurements). Interpretation will require visualisation of all reconstituted images as well as graphics, using your medical knowledge.

Pathological grids cannot be drawn up on the basis of DDFAO examinations because the same pathologies can cause different dysfunctions.

The level of deviation from homeostasis must be interpreted and a functional diagnosis made.

The measurement and interpretation provided by DDFAO does not take the clinical context or clinical examination into account, so the physician must make the synthesis between the measurement and the clinical context (pathology, pharmacopoeia, prior history….) which remains essential. Patients under medication (anti-inflammatories, antidepressants, antibiotics,

hypotensives, diuretics, hormones….) must specify their treatment. If the treatment is short-lasting, the examination can be postponed until 15 days after the end of treatment.

If the treatment is long-duration, the examination is performed taking into account the fact that most drugs reduce bioconductivity (basic terrain) except in the event of drug allergy, which, on the contrary, increases bioconductivity. In agreement with Pflaum's work on neurofunctional regulation, the function is, by

definition, dynamic, so that several records (stimuli) are needed to be able to judge homeostatic regulation.

Therefore, detecting organic or structural lesions which alter function can only take place dynamically. One measurement must be mad according to the standard and one using the automatic device, to make a functional diagnosis of a patient: The comparison with standard measurements will provide information on the patient's

functional status in real time and the functions of each system and organ with respect to the norm.

The automatic measurement will provide information on the functional status, taking

chronobiology into account and visualising the origin of the dysfunctions detected in organs or systems.

1- Neurophysiological, neurofunctional and neuroscientific bases The pH conditions the voltage and intensity of each zone of the body and determines the activity of Ca+ dependant voltage An tissue alkaline pH is a sign of:

Tissue hypoxia Vessel vasodilatation (increased NO and reduced catecholamines and serotonin) Increased cellular exchanges and tissue proliferation Increased apoptosis and genetic damage Reduced neuronal excitability Acidosis (Sanguineous)

An tissue acid pH is a sign of: Tissue hyperoxia Vessel vasoconstriction (reduced NO and increased catecholamines and serotonin) Reduced cellular exchanges and tissue proliferation Accelerated entropy Increased neuron excitability alkalosis(Sanguineous)

Functional diagnosis is performed by comparing the automatic measurement with the standard measurement, taking into account from both a diagnostic and a therapeutic points of view what is stabilised or aggravated in the automatic measurement. In the automatic measurement bioconductivity is increased: homeostatic status unbalanced possibility of:

stress (look for viral, bacterial infection, allergies, intoxication, seats of psychological disorders or conflicts) which could cause inflammation, the clinical context and complementary examinations are required to eliminate this possibility oxidizing stress by raising the redox potential search for interconnections and feedback effects of a functional or already

pathological psychoneuro-endocrino-immune function imbalance increased neuron excitability increased CO2 , catecholamines, serotonin and reduced NO and voltage dependent

Ca++ If this condition persists, and depending on its prior history (system feedback effects), increased bioconductivity can cause deficiency diseases: possibility of:

connectivity arthritis muscle contractions acute attacks of inflammatory osteoarthritis cardiovascular diseases : artherosclerosis , stoke diabetes Type II hypofertility thyroid deregulation adrenal gland deregulation hepatic deregulation degeneration of all kinds, including macular, impotence, dwarfism,

dryness of all kinds. Possibility of initiating benign or malignant tumoral processes development of necrotic processes allergy or intoxication (which are both types of inflammation) vicious post-traumatic sequelae, with or without reactional disturbing

or destabilising foci. reduced bioconductivity:

unbalanced homeostatic condition possibility of:

Chronic inflammation with vasodilatation and increased cell exchanges requiring a search for foci through complementary examination oxidizing stress through reduction of redox potential

search for interconnections and feedback effects of functional or already pathological psychoneuro-endocrino-immune imbalance reduced neuronal excitability reduced CO2 , catecholamines, serotonin and increased NO and voltage dependent

Ca++ If this condition persists, and depending on its prior history (system feedback effects), reduced bioconductivity can cause diseases due to excess: Possibility of:

osteoarthritis thyroid deregulation somesthetic disorders cardiovascular diseases : arteriosclerosis diabetes Type I adenomas fibromas Paget's disease polyposis Ocular hypertension Possibility of progression of benign or malignant tumour processes and

increased apoptotic processes.

2.Statistical interpretation (15000 measurements)

CASE 1 - This patient displays a strong potential for recovery with a possibility of rapidly reaching a state of vigilance and stress with no feedback effects (immunity and physiological limbic system). Ischemia in the phrenic zones and upper limbs is due to muscular tension. Hyperthroidism is the result of hyper-production by the hypothalamus and the hypophysis. Hypoexcitability of the frontal lobes reflects an increase in cerebral activity. This patient requires further examination, particularly with respect to the thyroid.

CASE 2 - This patient wants to become pregnant and has a menstrual delay (15 days) without pregnancy. She displays hormonal hypoproduction (hypophyseal zone), reduced immunity (T lymphocytes stored in the thymus). increased emotivity (limbic system) and increased cerebral activity (frontal lobes) indicating high stress (slaved right hand measurement)

CASE 3 - This patient takes hormone replacement treatment, which has caused a dysfunction of the hypothalamus and hypophyseal hormone production reflected in the thyroid. Ischemia in the upper limbs causes pain. Ischemia in the limbic system causes insomnia and tension headaches. Cardiovascular examinations have been prescribed

CASE 4 - This patient suffers from severe hormonal problems (hypothalamus and above all hypophyseal dysfunction). Ischemia reflects inflammation of the digestive system, kidneys and genital area, requiring further examination of these organs. Immunity is reduced, emotivity increased and the frontal lobes are in a state of hypoexcitation, indicating depression. Slaved measurement is used to note the level of asthenia and hypometabolism in this patient.

CASE 5 - Severe ischemia requiring further examination. Hormonal disorders. Feedback effects of stress in the immune and limbic systems. Digestive and urogenital examinations are necessary. In this case, there is a significant increase in cardiovascular risk.

CASE 6 - Stationary condition between the standard and automatic measurements, reflecting homeostatic imbalance with persistent stress leading to feedback effects with reduced immunity and short-term memory and increased emotivity. It is essential to find the cause of the stress through further examination.

CASE 7 - Patient displaying sympathetic dystonia with dysfunction of the hypothalamus and rapidly controlled stress in the chronobiology. However, since the problem is controlled by the left cortex (hyperexcitability), this dystonia should be monitored and a cardiovascular examination performed. The automatic measurement shows that the hypophyseal dysfunction is compensated; the posterior hypothalamus appears to be the reason for this. The patient is hypertensive and suffers from hypercholesterolemia. The slaved measurement of the limbic system indicates that the patient suffers from insomnia.

CASE 8 - Patient under anticoagulant following cardiopathy. The ischemia with feedback effects in the immune and limbic systems indicates that the this patient displays factors aggravating the pathology and the cardiovascular risk is greatly increased.

CASE 9 - Patient suffering from type I diabetes. Ischemia with increased sympathetic activity and stress are factors which aggravate the pathology. Emergency measures must be taken.

CASE 10 - This patient suffers from hyperproduction of vasopressin in the hypothalamus accompanied by hypertension and reduced diuresis, which is reflected by chronic asthenia.

CASE 11 - This patient suffers from hypothalamic and hypophyseal hyperproduction, indicating an increase in hormone production. Since diuresis is reduced, vasopressin is increased, leading to hypertension. The patient also suffers from insomnia (limbic system) Cardiovascular monitoring is essential for this patient.

• If the mean of all the recording branches is >+20: premature ageing, inflammatory

condition with increased cardiovascular risk, neurovegetative dystonia (spasmophilia), digestive intolerance, neuro-endocrine disorders, allergies, intoxication, increased risk of degenerative neurological disease.

Inherited disposition to allergy If the mean of all the recording branches is <-20: chronic fatigue, possibility of chronic inflammation, risk of genetic damage and cancerogenic initiation: degenerative terrain.

Degenerative state

• If cortisol, thyroxin, immunity and the left cortex display reduced bioconductivity: possibility of degenerative disease.

Diagnosed cancer

Multiple sclerosis

Clinical protocol

a) – All new patients have 4 measurements made: all using the automatic delta to optimise measurement. This measurement is automatic using the dynamic examination icon.

2 standard 30 second measurements

2 automatic 30 second measurements

We make the functional diagnosis by comparison between the 2nd visit using the automatic device (Aa) and the second visit using standard measurements (Na)

The dynamics between the standard examination and the automatic examination reveals the origin of the functional problems affecting the organs and systems visualised by the standard or slaved measurements: 2 examples

Greater bio conductivity problems indicating a state of stress. The origin of the dysfunction is hyper-production of the hypothalamo –hypophyseal pathway reflected in the thyroid.

However, in this case, hypothalamo-hypophyseal dysfunction is sustained and a urogenital disorder is indicated by the automatic measurement, confirming hypertension and hypercholesterolemia.

b) Depending on the changes in bioconductivity observed and aid in deciding on a proposed treatment: BRC MEDIBIO , homeopathy, somatic acupuncture, auricular acupuncture, osteopathy ….we start by regulating the target areas.

A new basic examination (30 seconds) is performed after 5 minutes:

There are 2 possibilities:

• bioconductivity is not regulated or has worsened

This is doubtless an organic or structural problem.

The measurements show the same image of lack of regulation when bio conductivity falls steeply from L1 to S5.

Examination recorded Examination 5 minutes after treatment

Further biochemical and lesional examinations are requested. Laboratory tests, X-rays.….. :

It is a case of ankylosing spondylitis.

All the cases we have sent for further examination have confirmed a more or less serious organic or structural biochemical problem.

In this case, biophysical treatment in association with conventional treatment may help the patient, particularly in the event of pain (auricular acupuncture)

• Bioconductivity is regulated

We then regulate the other zones until a well-balanced homeostatic result is obtained.

Examination obtained

Examination 5minutes after treatment

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The journal of Alternative and complementary Medicine Volume 8 Number 4 2002

Clinical trials "Approved"

Deputy Chief Medical Officer of S.P.Botkin municipal hospital clinic

Alexéev V.G. 25 June 2003

Report on clinical testing Computerized Screening and Functional Diagnosis - DDFAO System, composed as detailed in the appendix, produced by MEDI L.D. (France). Between 19 June and 25 June 2003, in the functional diagnosis section of the S.P.Botkin municipal hospital clinic, clinical tests were performed on the Computerized Screening and Functional Diagnosis - DDFAO, composed as detailed in the appendix, produced by MEDI L.D. (France). To perform these tests, a system, a technical trial report and documentation including a description of the system and the user manual were provided. The tests were intended to determine the main parameters and possibilities for recommending the use of the device in diagnostic establishments and prophylaxis centres. The tests were performed by employees of the functional diagnosis section, following prior instruction on how to use the system, provided by a MEDI L.D. (France) specialist. Computerized Screening and Functional Diagnosis - DDFAO System, composed as detailed in the appendix, produced by MEDI L.D. (France), is intended for use in rapid patient examination based on the analysis of electrical conductivity of human organs and systems. The patient examination is performed using six connected electrodes. The data recorded is transmitted to the computer. The DDFAO program analyses the data obtained and generates a large number of reports on the condition of the patient examined. Depending on the type of diagnosis to be made the examination takes between 30 seconds and 3 minutes. The program stores a database of patients, users and examinations as well as a dynamic analysis of the patient's condition over time. Because it is easy to use and highly effective, the DDFAO system can be used by various different types of medical establishment to make a rapid evaluation of a patient's condition. During development of the system we used the work done by R.Voll, V.Schmidt and X.Pflaum. The biophysics of the electrical characteristics of the human body are used to confirm that there is a range of values of electrical conductivity and capacity specific to a healthy body. Alterations in the state of individual organs and major systems influence these electrical characteristics. Measuring instruments are used to determine deviations when there is a rise or fall in these values. The values thus obtained from the signal between the different branches are within a range of –100 to 100 conventional units and are used to evaluate the state of the patient's organs and systems. Based on this information, the system performs the analysis and gives an indication of that state of the organs and systems – essential targets, the dysfunction of which can lead to various diseases

Required computer configuration: Processor – Pentium or higher, RAM – 32 Mb or more; disk space – at least 35 Mb; CD ROM drive; sound card, mouse. The program runs with all types of video adaptor resolution. Protocol The tests were performed on 65 patients between 19 June and 25 June 2003 The 65 patients were split into 4 batches: Batch 1: healthy patient with no known pathology or symptoms Batch 2: hepatic patients Batch 3: patients suffering from malignant tumours Batch 4: patients hospitalised with severe depression 33 women aged between 26 and 75 32 men aged between 24 and 82 Measurements were all taken dynamically (measurement time 2 minutes) The diagnosis took into account: The electrosomatogram: value of 22 volumes recorded The somatotom: value of 69 zones Standard deviation of the automatic examination Result Batch 1: healthy patient with no known pathology or symptoms Mean of electrosomatogram between –5 and +10 Mean of the 69 zones of the somatotom: between –10 and +12 Volumes of the electrosomatogram most affected: 115 17 3 4 bioconductivity increased 2 4 16 18 bioconductivity decreased Automatically controlled dynamic analysis: improvement of all values in automatic mode and standard deviation: 73 Zones of the somatotom most affected: phrenic zones and arm Batch 2: hepatic patients Mean of electrosomatogram: - 20 Mean of the 69 zones of the somatotom: - 23 Volumes of the electrosomatogram most affected: 1 2 3 4 5 6 bioconductivity decreased Automatically controlled dynamic analysis: aggravation of all the values and standard deviation: 60 Zones of the somatotom most affected: zones of the cortex and digestive system overall with diminished bioconductivity Batch 3: patients suffering from malignant tumours Mean of electrosomatogram:- 30 Mean of the 69 zones of the somatotome – 33 Volumes of the electrosomatogram most affected: 1 2 3 4 5 6 9 10 16 18 bioconductivity decreased Automatically controlled dynamic analysis: aggravation of all values in automatic mode and standard deviation: 47 Zones of the somatotom most affected: left cortex and immune system

Batch 4: patients hospitalized for severe depression Mean of electrosomatogram: - 10 Mean of the 69 zones of the somatotom - 12 Volumes of the electrosomatogram most affected: 1 3 16 18 bio conductivity strongly decreased Automatically controlled dynamic analysis: aggravation of values 1 3 16 18 in automatic mode and standard deviations: 63 Zones of the somatotom most affected: right and left cortex, limbic system and immunity. Discussion: It is clearly demonstrated that analysing the measurement of bio conductivity determined by the DDFAO examination detects the pathologies we selected (hepatitis, cancers, severe depression) simply through dynamic analysis of the electrosomatograms and somatotoms obtained and the standard deviation in automatic mode. Analysis of the standard deviation can also be used to judged the patients' recovery potential in both healthy and sick patients. The means of the results described above are: In batch 1: 73 % In batch 2: 77 % In batch 3: 79 % In batch 4: 89 % Which is extremely significant, although it is clear that this screening requires further examination to confirm the diagnosis. Conclusion: The DDFAO analyses the body's bio conductivity using a method requiring no intervention by either the patient or the practitioner in just 2 minutes and by producing reconstituted graphics and images such as the electrosomatogram, the somatotom and dynamic analysis using variable parameters is undeniably interesting in addition to the practitioner's clinical observations, and enables a functional delta to be determined and detects pathologies at an early stage. Computerized Screening and Functional Diagnosis - DDFAO System, meets modern requirements for advance diagnosis and may considerably reduce the time needed to prescribe methods of investigation or further treatment for patients. Computerized Screening and Functional Diagnosis - DDFAO System, can be used by diagnostic establishments and prophylaxis centres, and it is recommended for registration by the Russian Federation Ministry of Health, considering its composition as detailed in the Appendix of this Report. Physician in the functional diagnosis section Mertsalova O.N.

Appendix to the clinical test report of 25 June 2003

Composition of the Computerized Screening and Functional Diagnosis - DDFAO System 1. Device connected to the computer's USB port. 2. Electrodes to apply to the patient. 3. Connecting cables and wires. 4. DDFAO Multilingual CD – the DDFAO program. 5. User manual. Mertsalova O.N.

"Approved" General Manager

of the OOO "Jeldorpharmtrans" Medical centre

E.V. Lvova 03 July 2003

Report of clinical tests performed

on the computer aided functional diagnosis and screening system - DDFAO, composed as detailed in the appendix, produced by MEDI L.D. (France).

1. Test procedure

During the period of 23 June 2003 to 03 July 2003 at the OOO "Jeldorpharmtrans" medical centre, practicing diagnosis and treatment, covered by a licence, Serial N° MDKZ N°15032 / 6491 dated 18.07.2002, issued by the Moscow Public Health Committee, clinical tests were held concerning the computer aided functional diagnosis and screening system - DDFAO, composed as detailed in the appendix, produced by MEDI L.D. (France). Protocol Tests were performed on 70 patients between 23 June and 03 July 2003 49 women aged between 15 and 73 21 men aged between 19 and 78. The tests were performed on patients who visited the centre for various reasons. A dynamic CAFDS examination was performed and then, after clinical observation, the patients were sent for conventional examinations (laboratory tests, ECG, echography, X-rays….. ) Once the diagnosis was made, we looked at the CAFDS results again to determine the system's efficacy.

2. Composition of the system during tests The system is composed as indicated in the appendix to the report; technical documentation has been provided: description of the system and operating manual, technical and toxicological test reports.

3. Purpose of the tests To determine, through tests, the possibility of recommending the installation and use of the CAFDS system by diagnostic establishments, spas and prophylaxis centres.

4. Destination of the computer aided functional diagnosis and screening system – DDFAO

The computer aided functional diagnosis and screening system - DDFAO, being produced by MEDI L.D. (France), from the functional point of view, includes the DDFAO measuring

device and program, it is designed to make a rapid examination of a patient, based on an analysis of the volume conductivity of human organs and systems. During the examination, the patient is connected by six electrodes which measure the electrical characteristics of specific skin zones. Using the DDFAO device, running as a dependant interface controlled by a computer program, the data are entered into the computer and subjected to later processing by the DDFAO program, which analyses the data acquired and produces a large number of reports relative to the condition of the patient examined. Depending on the type of diagnosis involved, the examination lasts from 30 seconds to 3 minutes. The information on each new patient is entered into the database, thereby reporting on each of the patient's visits to analyse the dynamics of the patient's condition over time. Because it is very easy to use and extremely efficient, the computer aided functional diagnosis and screening system - DDFAO can be used in different medical establishments for fast evaluation of a patient's bodily condition and to detect any eventual pathologies. During development of the system we used the work done by R.Voll, V.Schmidt and X.Pflaum. The biophysics of the electrical characteristics of the human body allow us to confirm that there is a range of values of electrical conductivity and capacity specific to a healthy body. Alterations in the state of individual organs and major systems influence these electrical characteristics, increasing or reducing conductivity and capacity which are recorded by the DDFAO device. The signals obtained between the different branches are within a range of –100 to 100 conventional units and used to evaluate the state of the patient's organs and systems with sufficient accuracy. Based on this information, the system performs the analysis and gives an indication of the state of the organs and systems – essential targets, dysfunction of which can lead to various diseases Required computer configuration: Processor – Pentium or higher, RAM – 32 Mb or more; disk space – at least 35 Mb; CD ROM drive; sound card, mouse.. The program runs with all types of video adaptor resolution. The CAFDS device is connected to the computer's USB port. The DDFAO device does not require an external power supply.

5. Test procedure During clinical testing, the computer aided functional diagnosis and screening system - DDFAO, produced by MEDI L.D. (France) was used in the OOO "Jeldorpharmtrans" medical centre for fast patient diagnosis. 70 patients were examined. It was concluded that the data acquired could be used, with a high degree of certainty, to detect organs needing further examination or a visit to a specialist. The data from the examination of patients obtained using the computer aided functional diagnosis and screening system - DDFAO, were verified by specialised investigations. It was noted that the probability diagnostics provided by the DDFAO system showed a high degree of correlation with the data from investigations made using conventional methods. It appears that for various pathologies (spasmophilia, digestive intoxication, gastric ulcers, gallstones, tension migraines, arrhythmias ……) , the DDFAO system showed a degree of correlation with the data produced by the conventional tests to a level of 79,6 %.

6. Conclusion With a figure of 79.6 % of correlation between the diagnosis established and the DDFAO, it is undeniable that this system, with its ease of use and the time needed to take the measurement

( 2 to 3 minutes), is useful in addition to clinical observation in medical diagnostic centres, for directing the patient in a rational manner to other more costly examinations. the computer aided functional diagnosis and screening system - DDFAO composed as detailed in the appendix, produced by MEDI L.D. (France) (see the appendix to this report) meets modern requirements for advance diagnosis and may considerably reduce the time needed to prescribe methods of investigation or further treatment for patients. The computer aided functional diagnosis and screening system - DDFAO, can be used by diagnostic establishments and prophylaxis centres, and it is recommended for registration by the Russian Federation Ministry of Health, considering its composition as given in the Appendix of this Report. : Lobanova G.A.

Appendix to the clinical test report of 03 July 2003

Composition

the computer aided functional diagnosis and screening system – DDFAO: Device connected to the computer's USB port. Electrodes to apply to the patient. Connecting cables and wires. DDFAO Multilingual CD – the DDFAO program. User manual.

Lobanova G.A.