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DC Potential and the Brain Ali Gorji Epilepsy Research Center Münster University.
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Transcript of DC Potential and the Brain Ali Gorji Epilepsy Research Center Münster University.
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DC Potential and the Brain
Ali GorjiEpilepsy Research Center
Münster University
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Hans Berger became the first human electroencephalographer by recording the EEG signals used non-polarizable clay cylinder electrodes and Edelmann’s
small string galvanometer.
1924
Hans Berger (1873-1941)
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DC vs. AC Potentials
C
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Spreading depression
I
II
III
IV
V
VI
KCl
Horizontal propagation
10 s
DC4
DC3
DC2
DC1
2 mV
Vertical propagation
Front of excitation
Zone of depression
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Spreading depression recordings from living human brain tissues
Gorji et al., 2001
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Migraine aura is the human equivalent of cortical spreading depression
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Karl Spencer Lashley (1890-1958)
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Hadjikhani et al. 2001PNAS
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100µV1 s
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DC vs. AC Potentials
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DC Potential in Acute Brain Injury
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Spreading Depression and Epileptic Field Potentials in Human Brain
Dreier, et al., 2012
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DC Potential Changes and EEG
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Cortical DC Potential Associated with Food Intake in Hungry humans and Rats
Rats Human (Khaleghi et al., 2009) (Schmitt et al., 2001)
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Conclusion
• DC potentials of the brain comprise sustained displacements of the baseline as well as fluctuations between 0 Hz and 100 Hz including the frequency range of the conventional EEG.
• Neurons, glial cells and blood-brain barriers forming functional units may act as a compound generator of DC potentials.
• The slow components of neocortical DC potential shifts reflect changes in the level of excitation and excitability of the cortex.
• Negative DC fluctuation was also observed accompanied by ictal discharges in human brain.• Negative DC deflections were reported in patients suffering from hypoxic brain injuries . • Spreading depression, a negative DC deflection, has been shown to play crucial role in aura
phase of migraine with aura. • Psychophysiological studies revealed that DC potentials are highly sensitive to different
information processing and to personal characteristics of the people.
• It seems promising to extend DC potentials studies to provide further insights into mechanisms of brain function and dysfunction.
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Thanks for your attention
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Basic Mechanisms Underlying Generation of Potentials
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Membrane Potential Changes and Field Potentials
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Principle of Wave Generation
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EEG and Membrane Potential Changes
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Changes of DC/EEG during Asphyxia and Hypercapnia