DALTON CARDIOVASCULAR April 2018 RESEARCH CENTER
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2018 Americas User Group Meeng John Donahue, our User Support Specialist-Expert just returned from a week long training in San Francis- co, CA for the Bitplane’s Imaris Soſt- ware. John is amazed by the power of this image analysis soſtware. Please see John if you have interest in learning what this soſtware package can do for en- hancing your research. Brian Ruyle wins First Place Brian Ruyle, Graduate Research Assistant in the Laboratory of Ei- leen Hasser won First Place at the 25th Annual CV Poster contest for undergrad and graduate students. Brian’s poster tle, “PVN Projec- ons to the nTS are Essenal for Full Expression of Responses to Peripheral Chemoreflex Smulaon.” Anthony Belenchia Ph.D. Post Doc in the Laboratory of Lakshmi Pu- lakat, won third place in the Post Doctoral poster contest held during the 25th Annual CV Day. Dr Belenchia’s poster tle was, “ The Novel Cardio-Oncology Drug, NP- Anthony Belenchia Ph.D. wins at CV Day 6A4, Regulates the Growth of Multiple Breast Cancer Cell Lines rough Distinct Cell-Specific Mechanisms” Dr Allen W. Hahn 1933-2018 In 1969 the family moved back to his alma mater, the University of Missouri College of Veterinary Medicine, where he taught and conducted research at Dalton Cardiovascular Research Center. Breast Cancer Therapy in the news He was a professor at the veterinary college, teach- ing his passions: computer applicaons in veteri- nary medicine (veterinary informacs) especially arficial intelligence, expert systems and ECG pro- cessing; comparave cardiovascular performance and disease in non-human species; biological sens- ing electrodes; and biomaterials. He authored or co-authored more than 130 academic publicaons. He held five US patents for his research in the medical field. He received more than $2.3 million in grants for his research at the university. In 1993 Dr. Hahn received the University of Mis- souri Faculty Alumni Award, and in 2001 he re- ceived the Henry S. Geyer Award for public service to higher educaon. He was a lifeme honor roll member of the American Veterinary Medical Asso- ciaon. Click here to access the CVM website GRANT SUCCESS: Dr Lakshmi Pulakat, Resident Dalton Invesgator, Department of Medicine-Cardiology receives 4 year NIH RO1 award. Project Title: Mechanisms for Sex Differences in CVD Pathology and Development of a Targeted Therapeuc “In order to effecvely treat tumors, therapeucs are being developed that target mutant proteins that help grow cancer cells; APR-246 is one of those drugs,” said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardio- vascular Research Center. “However, we have idenfied another way to target cancer cells using APR-246 that aack breast tumor cells as well as anbodies that target the blood vessels that supply nutrients to tumors. Click here for enre arcle. April 2018 DALTON CARDIOVASCULAR RESEARCH CENTER
Transcript of DALTON CARDIOVASCULAR April 2018 RESEARCH CENTER
2018 Americas User Group MeetingJohn Donahue, our User Support Specialist-Expert just returned from a week long training in San Francis-co, CA for the Bitplane’s Imaris Soft-ware. John is amazed by the power of this image analysis software.
Please see John if you have interestin learning what this software package can do for en-hancing your research.
Brian Ruyle wins First PlaceBrian Ruyle, Graduate Research Assistant in the Laboratory of Ei-leen Hasser won First Place at the 25th Annual CV Poster contest for undergrad and graduate students. Brian’s poster title, “PVN Projec-tions to the nTS are Essential for Full Expression of Responses
to Peripheral Chemoreflex Stimulation.”
Anthony Belenchia Ph.D. Post Doc in the Laboratory of Lakshmi Pu-lakat, won third place in the Post Doctoral poster contest held during the 25th Annual CV Day.
Dr Belenchia’s poster title was, “ The Novel Cardio-Oncology Drug, NP-
Anthony Belenchia Ph.D. wins at CV Day
6A4, Regulates the Growth of Multiple Breast Cancer Cell Lines Through Distinct Cell-Specific Mechanisms”
Dr Allen W. Hahn1933-2018 In 1969 the family moved back to his alma mater, the University of Missouri College of Veterinary Medicine, where he taught and conducted research at Dalton Cardiovascular Research Center.
Breast Cancer Therapy in the news
He was a professor at the veterinary college, teach-ing his passions: computer applications in veteri-nary medicine (veterinary informatics) especially artificial intelligence, expert systems and ECG pro-cessing; comparative cardiovascular performance and disease in non-human species; biological sens-ing electrodes; and biomaterials. He authored or co-authored more than 130 academic publications. He held five US patents for his research in the medical field. He received more than $2.3 million in grants for his research at the university.
In 1993 Dr. Hahn received the University of Mis-souri Faculty Alumni Award, and in 2001 he re-ceived the Henry S. Geyer Award for public service to higher education. He was a lifetime honor roll member of the American Veterinary Medical Asso-ciation. Click here to access the CVM website
GRANT SUCCESS: Dr Lakshmi Pulakat, Resident Dalton Investigator, Department of Medicine-Cardiology receives 4 year NIH RO1 award. Project Title: Mechanisms for Sex Differences in CVD Pathology and Development of a Targeted Therapeutic
“In order to effectively treat tumors, therapeutics are being developed that target mutant proteins that help grow cancer cells; APR-246 is one of those drugs,” said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardio-vascular Research Center.
“However, we have identified another way to target cancer cells using APR-246 that attack breast tumor cells as well as antibodies that target the blood vessels that supply nutrients to tumors. Click here for entire article.
April 2018DALTON CARDIOVASCULAR
RESEARCH CENTER
Dr Kevin Gillis, Resident Dalton Investigator has some exciting news in that the Army Ants won the Engineer-ing Inspiration award at the FIRST St. Louis Regional competition last night! This is a prestigious award that qualifies the team to attend the FIRST Championship in Houston April 18-21st. The award ‘Celebrates out-standing success in advancing respect and appreciation for engineering within a team’s school or organization and community.’ The judges were deeply impressed by the number and quality of the outreach events that the Army Ants participated in (27 in 2017), as well as the central role that diversity and inclusion plays in Army Ants outreach through partnerships with GradeAPlus, Granny’s House and Benton STEM elementary.
To highlight the importance of community outreach, NASA pays the $5,000 registration fee for regional Engi-neering Inspiration winners to attend the FIRST champi-onship. In fact, this is the only award in FIRST that cov-ers the registration fee to Championship. Whereas the NASA grant covers the registration fee, the Army Ants will need to raise an additional ~$10,000 quite soon to cover the travel and hotel costs to attend Championship in Houston and compete for the national award. Going to Championship is a once-in-a-lifetime event for most of the kids on the team to reward them for their hard work on outreach and to inspire them to continue to grow their important work in the community.
The Army Ants also won the Rocket City Regional in Huntsville, Alabama! They finished qualifying matches ranked 3rd out of 46 teams and then were chosen as the first pick of the number one ranked team to be on the #1 alliance. They advanced through quarter and semi finals in straight sets and then won in the finals in a thrilling three-game match.
So the Army Ants have now demonstrated they are nationally competitive both on the field and in the community and look forward to seeing how far they can take it at the international championship in Houston in April.
Dr Kevin Gillis leads the Army Ants to competition!
Vevo LAZR Photoacoustic Imaging System and
Rodent Cardiocascular Phenotyping Facility
The Vevo LAZR Photoacoustic Imaging System and Rodent Cardiovascular Phenotyping Facility are ready for your use.
The overall goals of the facility are:
• To establish a core rodent cardiovascular phenotyping facility for the use of MU Investiga-tors to characterize the in vivo consequences of genetic and disease-based manipulations• To provide fee-for-service capabilities so as to decrease the needs of individual laboratories to establish their own testing facilities and pro-vide consistency/quality control of measurements• To provide a comprehensive core facility that will value-add to the programs of individual investigators and increase competitiveness for both external grant funding and interactions with industry.
To discuss or schedule use, please contact, Zhe Sun PhD, [email protected], or (573) 884-2499
Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Jia G, Hill MA, Sowers JR. Circ Res. 2018 Feb 16;122(4):624-638. doi: 10.1161/CIRCRESAHA.117.311586. Review. PMID: 29449364
Spontaneous oscillation in cell adhesion and stiffness measured using atomic force microscopy. Sanyour H, Childs J, Meininger GA, Hong Z.Sci Rep. 2018 Feb 13;8(1):2899. doi: 10.1038/s41598-018-21253-9. PMID: 29440673
Imaging of Mitochondrial and Cytosolic Ca2+ Signals in Cultured Astrocytes. Zhang N, Ding S. Curr Protoc Neu-rosci. 2018 Jan 22;82:2.29.1-2.29.11. doi: 10.1002/cpns.42. PMID: 29357111
Cardiovascular disease progression in female Zucker Diabetic Fatty rats occurs via unique mechanisms com-pared to males. Lum-Naihe K, Toedebusch R, Mahmood A, Bajwa J, Carmack T, Kumar SA, Ardhanari S, De-Marco VG, Emter CA, Pulakat L. Sci Rep. 2017 Dec 19;7(1):17823. doi: 10.1038/s41598-017-18003-8. PMID: 29259233
Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman’s summary. Mall MA, Hwang TC, Braakman I. J Cyst Fibros. 2018 Mar;17(2S):S1-S4. doi: 10.1016/j.jcf.2017.11.008. Epub 2017 Dec 9. Review. PMID: 29229473
Remote Activation of a Nanopore for High-Performance Genetic Detection Using a pH Taxis-Mimicking Mech-anism. Wang Y, Tian K, Du X, Shi RC, Gu LQ. Anal Chem. 2017 Dec 19;89(24):13039-13043. doi: 10.1021/acs.analchem.7b03979. Epub 2017 Dec 4. PMID: 29183111
What is the potential of nanolock- and nanocross-nanopore technology in cancer diagnosis? Gu LQ, Gates KS, Wang MX, Li G. Expert Rev Mol Diagn. 2018 Feb;18(2):113-117. doi: 10.1080/14737159.2018.1410060. Epub 2017 Dec 1. No abstract available. PMID 29171309
Jia, G., Habibi, J., Annayya R. Aroor, A.R., Hill, M.A., DeMarco, V.G., Li E. Lee, L.E., Ma, L., Barron, B.J., Wha-ley-Connell, A., and Sowers, J.R. Enhanced endothelium epithelial sodium channel signaling prompts left ven-tricular diastolic dysfunction in obese female mice. Metabolism 78:69-79, 2018.
Ho, I-L., Nourian, N., Hill, M.A., Meininger, G.A., Li, W.Y. Quantification of elastin-fiber reticulation in rat mes-enteric arterioles using molecular dynamics optimization. Biomedical Physics & Engineering Express, Accepted for Publication.
Qiu, T., Li, M., Yang, Y.A., Sowers, J.R., Korthuis, R.M. and Hill, M.A. Depletion of dendritic cells in perivascular adipose tissue improves arterial relaxation responses in type 2 diabetic mice. Metabolism Accepted for Publi-cation, 2018
Publications
Structural mechanisms of CFTR function and dysfunction. Hwang TC, Yeh JT, Zhang J, Yu YC, Yeh HI, Destefano S. J Gen Physiol. 2018 Mar 26. pii: jgp.201711946. doi: 10.1085/jgp.201711946. [Epub ahead of print] Review.PMID: 29581173
Gene Expression Profiles of Ion Channels and Receptors in Mouse Resistance Arteries: Effects of Cell Type, Vas-cular Bed and Age. Boerman EM, Sidharth S, Shaw RL, Joshi T, Segal SS. Microcirculation. 2018 Mar 25:e12452. doi: 10.1111/micc.12452. [Epub ahead of print] PMID: 29577514
Chronic Interval Exercise Training Prevents BKCa-channel Mediated Coronary Vascular Dysfunction in Aor-tic-Banded Mini-Swine.Olver TD, Edwards JC, Ferguson BS, Hiemstra JA, Thorne PK, Hill MA, Laughlin MH, Em-ter CA.J Appl Physiol (1985). 2018 Mar 29. doi: 10.1152/japplphysiol.01138.2017. [Epub ahead of print] PMID: 29596016
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