The Tricarboxylic Acid Cycle Krebs’ Cycle Citric Acid Cycle Hans Krebs.
D. KREBS CYCLE. 2. occurs in the matrix of the mitochondria 3. only occurs if oxygen is present 1....
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Transcript of D. KREBS CYCLE. 2. occurs in the matrix of the mitochondria 3. only occurs if oxygen is present 1....
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D. KREBS CYCLE
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2. occurs in the matrix of the mitochondria
3. only occurs if oxygen is present
1. Krebs cycle allows the cell to get more energy out of the acetyl-CoA product of the oxidation of pyruvate
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remember the cell is trying to
release NAD+ to allow glycolysis to continue
produce ATP
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COOHO=C CH2
COOH
COOH CH2
HOC – COOH CH2
COOH
acetyl-CoA
CH3
C=O S-CoA
4. Details
H2O
CoA-SH
hydrase
oxaloacetate
citrate
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COOH CH2
HOC – COOH CH2
COOH
COOH CH2
HC – COOH HOCH COOH
isomerase
citrate
isocitrate
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COOH CH2
HC – COOH HOCH COOH
COOH CH2
CH2 C=0 COOH
NAD+
NADH + H+
CO2
dehydrogenase
decarboxylase
isocitrate
alpha-ketoglutarate
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COOH CH2
CH2 C=0 COOH
COOHCH2
CH2
C=OS – CoA
NAD+
NADH + H+
CO2
CoASH
dehydrogenase
decarboxylase
alpha-ketoglutarate
succinyl-CoA
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COOHCH2
CH2
C=OS – CoA
COOHCH2
CH2
COOH
CoASH
GTP
GDP + Pi
ADP
ATP
phosphorylase
H2O
hydrase
succinyl-CoA
succinate
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COOHCH2
CH2
COOH
COOH CH llHC COOH
FAD+
H2
dehydrogenase
FAD
succinate
fumarate
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COOH CH llHC COOH
COOHHOCH CH2
COOH
H2O
hydrase
fumarate
malate
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COOHHOCH CH2
COOH
COOHO=C CH2
COOH
NAD+
NADH + H+
dehydrogenase
malate
oxaloacetate
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START AGAIN
COOHO=C CH2
COOH
COOH CH2
HOC – COOH CH2
COOH
acetyl-CoA
CH3
C=O S-CoA
Oxaloacetate
citric acid
so this is sometimes called the citric acid cycle
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5. EQUATION:
acetyl-CoA + 3 NAD+ + FAD+ + H20 + ADP + Pi
2 CO2 + 3 [NADH + H+] + FADH2 + ATPCoASH +
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E. SUMMARY – so far for HIGH ENERGY PRODUCTS
where
glucose glycolysis
cytoplasm
2 ATP
oxidation of pyruvate
oxidation of pyruvate
matrix of mitochondria
2 [NADH + H+]
4 ATP
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oxidation of pyruvate
oxidation of pyruvate Kreb’s cycle
Kreb’s cycle
2 [NADH + H+] 2 ATP6 [NADH + H+]
2 FADH2
matrix of mitochondria
where
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remember the cell is trying to
release NAD+ to allow glycolysis to continue
produce ATP
Krebs made no NAD+, it used 6
Krebs made only 2 more ATP