D. James CooperRussell Gruen

National Health & Medical Research Council (NHMRC)

Funding dates: 2014-2016

The Alfred, Melbourne Australia

supported

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.

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ANZIC-Research Centre, Monash University

High impact TBI research for 15 years

Current multicenter RCTs

N=500Severe TBI, Prophylactic hypothermiaEarly/prolonged/slow

N=600Mod /severe TBIErythropoietin

Overview

Primary research question or hypothesis Comparative Effectiveness Research approach will identify

most effective clinical interventions for TBI pts world-wideNumber of subjects

100 ICU at Alfred Hospital; (1800 ICU in CENTER)Study design

Prospective longitudinal observational cohort study Australian ICU stratum sites within global CER

Aus: Trauma system, multi-discipline ICU, intensivist led, high nursing ratios, outcomes Registries, collaborative research ethic

Living reviews / translation hub Complete Australian TBI RCTs with Europe sites

Participation in InTBIR

What are your expectations for joining InTBIR? Help maximize strength of global TBI collaboration Maximize TBI patient diversity within InTBIR Working within InTBIR will enable Global results to

best inform our management, speed of translation, and guide research

Participation in InTBIR

How might your participation contribute to achieving the mission of InTBIR ? Assist patient recruitment in ICU stratum of CENTER Assist generalizability European findings to another

first world center Broaden practice variation for the world-wide CER Link Australia into the global collaboration Compare Australian structures / therapies / outcomes

with other world centers

Participation in InTBIR

Do you already have an ongoing collaboration with InTBIR projects? What successes and issues so far?

Collaboration with CENTER-TBI Success: Collaborative NHMRC-EC Funding Issues: Funding cut by 2/3 ($375K/3 yrs). CRE grant

for TBI research and OzENTER – not successful. Monash Co-ordination Centre and Translation Centre Planning for modified start up at Alfred late 2014

MRI/DTI technical issues tested over 2 years

Participation in InTBIR

Is the funding agency currently supporting your project open to international collaboration under the umbrella of InTBIR?

In principle - Yes.