Cylindrical Ion Trap Mass Spectrometer for Chemical ... · IMS Einzel Lens Square Quad Skim CIT mer...
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Cylindrical Ion Trap Mass Spectrometer for Chemical Warfare Agent Detection and
Identification
Cylindrical Ion Trap Mass Spectrometer for Chemical Warfare Agent Detection and
IdentificationM. Todd Griffin, Jack E. Fulton, Jr., Robert F. McAtee,
Norm Popkie, Michael A. Eagan, Mike Jahn
Night Vision/Electro Optics and Chemical/Biological/Explosives Detection Group Naval Surface Warfare Center, Crane Division
Crane, IN 47522
Rong Gao, Lefteri H. Tsoukalas, R. Graham CooksPurdue University
W. Lafayette, IN 47907-1290Distribution Statement A - Approved for public release; distribution unlimited.
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Report Documentation Page Form ApprovedOMB No. 0704-0188
Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering andmaintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information,including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, ArlingtonVA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if itdoes not display a currently valid OMB control number.
1. REPORT DATE 01 OCT 2005
2. REPORT TYPE N/A
3. DATES COVERED -
4. TITLE AND SUBTITLE Cylindrical Ion Trap Mass Spectrometer for Chemical Warfare AgentDetection and Identification
5a. CONTRACT NUMBER
5b. GRANT NUMBER
5c. PROGRAM ELEMENT NUMBER
6. AUTHOR(S) 5d. PROJECT NUMBER
5e. TASK NUMBER
5f. WORK UNIT NUMBER
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Night Vision/Electro Optics and Chemical/Biological/Explosives DetectionGroup Naval Surface Warfare Center, Crane Division Crane, IN 47522
8. PERFORMING ORGANIZATIONREPORT NUMBER
9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S)
11. SPONSOR/MONITOR’S REPORT NUMBER(S)
12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release, distribution unlimited
13. SUPPLEMENTARY NOTES See also ADM001851, Proceedings of the 2003 Joint Service Scientific Conference on Chemical &Biological Defense Research, 17-20 November 2003. , The original document contains color images.
14. ABSTRACT
15. SUBJECT TERMS
16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT
UU
18. NUMBEROF PAGES
17
19a. NAME OFRESPONSIBLE PERSON
a. REPORT unclassified
b. ABSTRACT unclassified
c. THIS PAGE unclassified
Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18
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Selective, Rapid Detection of Chemical Warfare Agents
in Air by Ion Trap Mass Spectrometry! Requirements, field portable plus
" Speed of analysis: < 10 seconds" Sensitivity: LOD < 1 part per trillion by volume" Selectivity: samples are complex mixtures of organics
! The Solution" Miniature mass spectrometer" Ion trap with simple cylindrical electrodes " Rapid, selective membrane introduction of samples
! Basis for Effort" Detailed simulations of ion motion in ion traps" Decade-long study of ion trap performance" Collaboration between Purdue, Crane, and Griffin, a start-up
company who will manufacture instruments
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Methodology
•Selective Adsorption/Desorption•Selective Ionization•Selective Mass Analysis•Selective Dissociation and MS/MS Analysis
Air Sample
Membrane Selective Desorption
Mass Analysis
MS/MSAnalysis
Detection
DataAnalysis
Preconcentration of analytes
Thermal Release Laser or CI
Multiple Stages of Selectivity
Ion trap (CIT)Selective Binding
SelectiveIonization
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BEEQ –Research grade laboratoryInstrumentSize: BigWeight : 4 tonsPower : 15,000 W
Mini-CIT Ver. 5.0Size: 45 x 60 x 71 cmWeight: 140 lbsPower: 200 - 300 W
Mini-CIT Ver. 7.0•Size 18cm x 28cm x 65cm•Weight: 60 lbs•Power 120W
Miniaturization of the Mass Spectrometer
Modified ITSModified ITS--40 40 Rugged Rugged TransportableTransportableSize: 200x 200x 100 cmWeight: 800 lbsPower: 4500 W
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Current Commercial System
Griffin Analytical Technologies
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0
0 .0 5
0 .1
0 .1 5
0 .2
0 .2 5
0 .3
0 .3 5
0 .4
50 70 90 110 130 150 170 190
156
123
55,57
69,71
78-87
95
109
m/z Thomson
Rel
ativ
e In
tens
ity
Halls cough drops (12 mg menthol per drop) in airmini 5.0 with internal unheated membrane
OH
Menthol
C10H20O
MW 156.27
Mini Mass Spec Monitoring of Menthol from Cough Drops in Air
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0.9 V peak heightRise :30 sec.Fall: 30 sec.
0.45 V peak heightRise :26 sec.Fall: 26 sec.
Altoid in Air: Mini Mass Spec Trap and Release MIMS
30s heatBlank
15s Altoid
60s heat
30s heat
3 .00E +00
4 .00E +00
5 .00E +00
6 .00E +00
7 .00E +00
8 .00E +00
9 .00E +00
1 .00E +01
1 .1 0E +01
1 .2 0E +01
1 .3 0E +01
0 1 6 3 2 4 8 6 4 8 0 9 6
1 2 3 4 5 6
3 .0 0 E + 0 0
4 .0 0 E + 0 0
5 .0 0 E + 0 0
6 .0 0 E + 0 0
7 .0 0 E + 0 0
8 .0 0 E + 0 0
9 .0 0 E + 0 0
1 .0 0 E + 0 1
1 .1 0 E + 0 1
1 .2 0 E + 0 1
1 .3 0 E + 0 1
0 1 6 3 2 4 8 6 4 8 0 9 6
1 2 3 4 5 6
30s heat
30s Altoid
60s heat
30s heat
Blank
Blank
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Membrane Introduction Test Set
• Flow-Bench with mass flow meters• RTDs/Humidity sensors• Variable membrane heater• Vacuum chamber with variable pump• Dual chamber vapor generator• Automated testing
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Mini-Mass Spectrometer
Ion Lenses
Cylindrical Ion Trap
r0 = 2.5 mm
Sample Inlet
Current DesignNew DesignFilament
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1 pg of methyl salicylate in 1 µL methanol
0
0.05
0.1
0.15
70 90 110 130 150 170 190
Methyl Salicylatem/z 152
m/z (Thomson)
0
0.05
0.1
0.15
70 90 110 130 150 170 190
nitrotoluenem/z 137
nitrotoluenem/z 107
nitrotoluenem/z 91
m/z 77, 79
m/z 156
152Resolution ~100
Toluene with membrane inlet91
92
90 95m/z (Thomson)
Performance Characteristics: Sensitivity and Resolution
background subtracted
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MSn of Methyl Salicylate
0.00
0.50
1.00
1.50
5.0 6.0 7.0 8.0 9.0 10.0 11.0 12.0 13.0 14.0 15.0
152CID: 0 Vm/z 152
0.00
0.50
1.00
1.50
5.0 6.0 7.0 8.0 9.0 10.0 11.0 12.0 13.0 14.0 15.0time (ms)
152
120CID: 0.02 V
CID: 0 Vm/z 120
0.00
0.50
1.00
1.50
5.0 6.0 7.0 8.0 9.0 10.0 11.0 12.0 13.0 14.0 15.0time (ms)
152CID: 0.02 V
m/z 120
m/z 92m/z 152
0.00
0.50
1.00
1.50
5.0 6.0 7.0 8.0 9.0 10.0 11.0 12.0 13.0 14.0 15.0
m/z 92m/z 120
m/z 152
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• Wavelet transform
– Definition
– Admissible condition
– Inverse transform
( ) ( )∫
−= dt
a
ttx
aaWTx
τψτ *1,
( )∞<
Ψ= ∫
∞
0
2
ωωω
ψ dc
( ) ( )∫ ∫∞ ∞+
∞−
−=
0 2
1,
1 ττψτψ
da
t
aaWT
a
da
ctx x
Wavelets
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0 5 0 0 1 0 0 0 1 5 0 0 2 0 0 0 2 5 0 0- 0 . 8
- 0 . 6
- 0 . 4
- 0 . 2
0
0 . 2
0 . 4
0 . 60 5 0 0 1 0 0 0 1 5 0 0 2 0 0 0 2 5 0 0
- 0 . 8
- 0 . 6
- 0 . 4
- 0 . 2
0
0 . 2
0 . 4
0 . 6
Single scan of methyl salicylate
Original and processed data
Signal Processing of DataWavelet Filtering
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0 500 1000 1500 2000 2500-0.2
-0.15
-0.1
-0.05
0
0.05
0.1
0.15
0.2
0.25
Results after trend removal
Signal Processing of DataWavelet Filtering
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CIT Automated Test Set
• Fully automated PXI based control system • Control software written in LabVIEW• Leak valve and membrane introduction system• Couple with flow bench and vapor generator
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Future Work
IMS Einzel Lens
Square Quad
CITSkimmer
Tube Lens
IMS-MS
CITCIT
Einzel Lens
Einzel Lens
Source Array
Source Array
Filament Array
Filament Array
Multiplexed CIT
• System integration• Performance optimization• IMS-MS• Multiplexed CIT• Biological Capabilities• Algorithm Development
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Funding:Integrated Detection of Hazardous Materials (IDHM) Program, a Department of Defense project managed jointly by Center for Sensing Science and Technology, Purdue University, and Naval Surface Warfare Center, Crane, Indiana
Robert Santini, Andy Guymon, Chris Doerge, Mark Carlsen, MikeEverly, Jim Zimmerman, Alan Ronemus, Robert Fagan, RandyRapogle, and Greg Hawkins.
Dr. Cooks acknowledges the technical support of the Amy Instrumentationand Dr Robert Santini provided via the Indiana Instrumentation Institute (III).
Acknowledgements