Cuthbert SRF Forum May 2014
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Transcript of Cuthbert SRF Forum May 2014
Schizophrenia Research ForumWebinarMay 28, 2014
Bruce N. Cuthbert, Ph.D.
Director, Division of Adult Translational Research
National Institute of Mental Health
Toward Precision Medicine for Mental Disorders:NIMH Research Domain Criteria (RDoC)
Disclosures
• Dr. Cuthbert is a Title 42 federal employee who is required to disclose all financial holdings as public record, and has no outside activities to disclose.
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Schizophrenia: A complex syndrome
• Highly heterogeneous
• Michael Owen: “There is no such thing as schizophrenia.”
• Psychosis, hallucinations in other disorders
• Research task: Study the individual differences to find more precise diagnosis and intervention
Polygenic Risks for Mental Disorders
Cross-Disorder group of the PGC,Lancet, 2013
Neurodevelopment and Plasticity
Neurodevelopment
Environment
Age
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NIMH Strategic Plan: Goal 1.4
• “Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.”
[Symptoms]• Elevated Stress
• Heightened threat reactivity
• Abnormalities in reward-related activity• Substance abuse
• Hippocampus: encoding functions• Perceptual aberrations
• Social withdrawal• Need for social relationships
• Disruptions in network connectivity• Dysfunctions in arousal/activation systems
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RDoC: Quick Summary
• A framework to study mechanisms that cut across traditional disorder boundaries
• Dimensional approach – understand transitions from normal to mild, moderate, severe dysfunction
• Will inform, not compete with, future versions of DSM and ICD
• Toward personalized medicine in psychiatry, consistent with other areas of medicine
• http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml