LYDIA REBECCA MEADOR

Biological Design, PhD Candidate Arizona State University

Tempe, AZ 85281 E-mail: lydia.meador@asu.edu

Phone: 918-671-8420 648 W Edgewood Ave, Mesa, AZ 85210

EDUCATION

Ph.D., Biological Design, expected graduation August 2016, Arizona State University, Tempe, AZ NSF Graduate Research Fellow Philanthropic Education Organization Scholar ASU Dissertation Fellow Committee: Dr. Bertram Jacobs (Co-Chair), Dr. Tsafrir Leket-Mor (Co-Chair), Dr. Hugh Mason, Dr.

Joseph Blattman Dissertation: Searching for an HIV vaccine: a novel heterologous prime-boost strategy combining

replicating vaccinia virus and plant-produced virus-like particles

B.S., Botany with honors, B.S., Microbiology-Molecular Genetics, May 2011, Oklahoma State University, Stillwater, OK

Double Major: Biochemistry & Molecular Biology Honors thesis: Characterization and evolutionary potential of tandemly duplicated genes in

Arabidopsis thaliana and Arabidopsis lyrata

PUBLICATIONS

Kessans SA, Linhart M, Meador LR, Kilbourne J, Fromme P, Matoba N, Mor TS. 2014. Immunological characterization of plant-based HIV-1 gag/dgp41 virus like particles. Accepted. PLOS One

Meador LR, Mor TS. 2014. Virus-like particles and nanoparticle vaccines 2014: session 5 (plant-based technology). Human Vaccines and Immunotherapuetics. 10:10, 3068-3073.

Gong Z, Kessans SA, Song L, Dorner K, Lee H, Meador LR, LaBaer J, Hogue BG, Mor TS, Fromme P. 2014. Recombinant expression, purification and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41. Protein Science 23(11): 1607-1618.

TEACHING EXPERIENCE

Teaching Assistantships 2013 Course: Advanced Immunology Dr. Joseph Blattman, Arizona State University Led discussion groups for immunology case studies and gave a lecture on HIV

pathogenesis Student Mentoring 2016 Mentor for interns: Book Thanchanok & Apisara Ausawasamrit

Meador 2

Laboratory of Dr. Tsafrir Leket-Mor Project: Expression and purification of chlorotoxin-mCD3 Fab fusion protein in Nicotiana

benthamiana 2016-present Mentor for undergraduate: Siavosh Naji-Talakar Laboratory of Dr. Tsafrir Leket-Mor Project: Attempting to decrease dgp41 toxicity to plants by disrupting interaction with

calmodulin in an effort to make transgenic plants for vaccine protein production

2016-present Mentor for undergraduate: Michelle Di Palma Laboratory of Dr. Tsafrir Leket-Mor Project: Difference in immunogenicity of plant-produced Gag/dgp41 HIV virus-like

particles with altered protein ratios from multiple expression vectors

2015-present Mentor for undergraduate: Caroline Snyder Laboratory of Dr. Bertram Jacobs Project: Toxicity of deconstructed-gp41 expression in mammalian cell culture involves a

calcium dependent ER stress pathway

2015-present Mentor for undergraduate: Marissa Kaufman Laboratory of Dr. Tsafrir Leket-Mor Project: Purification of His-tagged HIV virus-like particles for structural characterization

2014-present Mentor for undergraduate: William Martelly Laboratory of Dr. Bertram Jacobs Project: Plant-produced HIV virus-like particle stimulation of innate signaling pathways

in cell culture

2014-2015 Mentor for undergraduate: Roberto Torres Laboratory of Dr. Tsafrir Leket-Mor Project: Comparison of plant viral expression vectors to increase yield of HIV virus-like

particles in Nicotiana benthamiana

2014-present Mentor for undergraduate: Rebekah Dickey Laboratory of Dr. Tsafrir Leket-Mor Project/Honors thesis: Plant-produced HIV virus-like particle stimulation and activation

of immune cells

2013-2014 Mentor for senior undergraduate: Patrick Cervantes Laboratory of Dr. Tsafrir Leket-Mor Project: Comparison of plant viral expression vectors to increase yield of HIV virus-like

particles in Nicotiana benthamiana

Spring 2013 Teaching Assistant, Advanced Immunology (MIC 425/598) Instructor: Dr. Joseph Blattman Involvement: leading case study discussions, teaching one lecture on HIV

pathogenesis and protection, grading papers

2012-2013 Mentor for senior undergraduate: David Beaumont Laboratory of Dr. Tsafrir Leket-Mor

Project: Increasing expression of the HIV membrane protein dgp41 in Nicotiana benthamiana using geminiviral vectors

Meador 3

PAPER PRESENTATIONS

Meador LR, Kessans SA, Dickey R, Kaufman M, Martelly W, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Poster title: Immunological characterization of an HIV vaccine comprised of Gag and dgp41 virus-like particles produced both in plants and by live Vaccinia virus vectors. Awards Gala for the Arizona Bioindustry Association. Phoenix, AZ. 3 October, 2015.

Meador LR, Kessans SA, Dickey R, Kaufman M, Martelly W, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Oral presentation: Immunological characterization of virus-like particles produced both in plants and by live Vaccinia virus vectors as a vaccine candidate for HIV. 34th Annual Meeting of the American Society for Virology. London, Ontario, Canada. 11-15 July, 2015.

Meador LR, Kessans SA, Dickey R, Kaufman M, Martelly W, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Poster title: Immunological characterization of an HIV vaccine comprised of Gag and dgp41 virus-like particles produced both in plants and by live Vaccinia virus vectors. 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Vancouver, British Columbia, Canada. 19-22 July, 2015.

Meador LR and Charles Arntzen. Exhibit poster: ZMapp: An Experimental Treatment for Ebola Made in Tobacco Plants. American Public Health Assocation Annual Meeting. New Orleans, LA. 16-19 November, 2014.

Meador LR, Martin T, Mason H, Jacobs BL, Blattman JN, Mor TS. Poster title: Production of LCMV glycoprotein virus-like particles in Nicotiana benthamiana as a murine model of protective vaccination strategies for HIV. Arizona Bioindustry Association. Scottsdale, AZ. 19 June 2014.

Meador LR, Martin T, Mason H, Jacobs BL, Blattman JN, Mor TS. Poster title: Production of LCMV glycoprotein virus-like particles in Nicotiana benthamiana as a murine model of protective vaccination strategies for HIV. Virus-like particles and nano-particle vaccines. Salk Institute. La Jolla, CA. 4-6 June, 2014.

Meador LR, Kessans SA, Beaumont DM, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Oral presentation: Testing an HIV vaccine using live vaccinia virus and plant-produced Gag and dgp41 virus-like particles. Plant Based Vaccines, Antibodies, and Biologics. Verona, Italy. 4-7 June 2013.

Meador LR, Kessans SA, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Poster title: Creation of a novel HIV vaccine using live vaccinia virus and plant-produced Gag and dgp41. Graduate and Professional Student Association Fall Welcome Event. Arizona State University. Tempe, AZ. 2012.

Meador LR, Kessans SA, Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and Mor TS. Poster title: Creation of a novel HIV vaccine using live vaccinia virus and plant-produced Gag and dgp41. XIX International Poxvirus, Asfarvirus, and Iridovirus Conference. Salamanca, Spain. 26 June 2012.

Meador LR, Steets JA, Meinke D. Oral Presentation: Characterization and evolutionary potential of tandemly duplicated genes in Arabidopsis thaliana and Arabidopsis lyrata. National Conference on Undergraduate Research. Ithaca University. Ithaca, NY. 2011.

Meador LR, Steets JA, Meinke D. Oral Presentation: Characterization and evolutionary potential of tandemly duplicated genes in Arabidopsis thaliana and Arabidopsis lyrata. Honors thesis presentation/defense. Oklahoma State University. Stillwater, OK. 2010.

Meador LR, Steets JA. Oral Presentation: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Oklahoma-Louis Stokes Alliance for Minority Participation Annual Symposium. Oklahoma State University. Stillwater, OK. 2010.

Meador 4

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Biochemistry and Molecular Biology Annual Symposium for the Biological Sciences. Oklahoma State University. Stillwater, OK. 2010.

Meador LR, Steets JA. Oral Presentation: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Niblack Research Scholars Symposium. Oklahoma State University. Stillwater, OK. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Ecological Society of America Conference. Pittsburgh, PA. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Evolution 2010 Conference. Oregon Convention Center. Portland, OR. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. National Conference for Undergraduate Research. University of Montana. Missoula, MT. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Oklahoma State University Research Week. Stillwater, OK. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Oklahoma Research Day at the Capitol. Oklahoma City, OK. 2010.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Oklahoma EPSCoR Research Day. Northeastern State University - Broken Arrow, OK. 2009.

Meador LR, Walker PT, Shi MZ, Xie DY. Oral Presentation: Characterization of suspension-cultured PAP1 transgenic cells through growth, anthocyanins, and gene expression. Phytochemistry Society of North America Meeting. Towson University. Baltimore, MD. 2009.

Meador LR, Walker PT, Shi MZ, Xie DY. Oral Presentation: Characterization of suspension-cultured PAP1 transgenic cells through growth, anthocyanins, and gene expression. North Carolina State University Undergraduate Research Symposium. Raleigh, NC. 2009.

Meador LR, Steets JA. Poster title: Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana. Wentz Research Scholar Symposium, Oklahoma State University. Stillwater, OK. 2009.

Meador LR, Steets JA. Poster title: Polymorphism in microsatellite loci in Impatiens capensis. National Conference for Undergraduate Research. University of Wisconsin. La Crosse, WI. 2009.

Meador LR, Steets JA. Poster title: Polymorphism in microsatellite loci in Impatiens capensis. Oklahoma State University Research Week. Stillwater, OK. 2009.

Meador LR, Steets JA. Poster title: Polymorphism in microsatellite loci in Impatiens capensis (Balsaminaceae). Freshman Research Scholars Symposium. Oklahoma State University. Stillwater, OK. 2008.

Meador LR, Steets JA. Poster title: Polymorphism in microsatellite loci in Impatiens capensis (Balsaminaceae). Oklahoma Academy of Sciences Fall Technical Meeting. Southern Nazarene University. Oklahoma City, OK. 2008.

Meador 5

PROFESSIONAL EXPERIENCE

2011-Present National Science Foundation Graduate Research Fellow, Biological Design Ph.D. Program Developing a novel HIV vaccine using live Vaccinia virus and plant-produced Gag and

dgp41 Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State

University Supervisors: Dr. Tsafrir Leket-Mor and Dr. Bertram Jacobs

2011-2012 Graduate Research Assistant, Biological Design Ph.D. Program Rotation project: Human IgG construct expression comparison and cloning of

xylosyltransferase and fucosyltransferase in Nicotiana benthamiana Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State

University Supervisor: Dr. Hugh Mason

2010-2011 Wentz Research Scholar Effects of genetic modification on antioxidant production in canola meal Department of Biosystems and Agricultural Engineering, Oklahoma State University Supervisor: Dr. Nurhan Dunford

Honors Thesis Evolution of tandem arrays of duplicated genes in Arabidopsis thaliana and Arabidopsis lyrata Department of Botany, Oklahoma State University Supervisors: Dr. David Meinke and Dr. Janette A. Steets

2009-2010 Niblack Research Scholar Interactive effects of herbivory and drought stress for leaf hair production and evolution in Arabidopsis kamchatica Department of Botany, Oklahoma State University Supervisor: Dr. Janette A. Steets

Summer 2009 NSF Synthetic Biology Research Experience for Undergraduates Characterization of suspension-cultured PAP1 transgenic cells through growth, anthocyanins, and gene expression

Department of Plant Biology, North Carolina State University Supervisor: Dr. De-Yu Xie

2008-2009 Wentz Research Scholar Within- and between-generation effects of drought stress for leaf hair production and flowering time in Arabidopsis thaliana Department of Botany, Oklahoma State University Supervisor: Dr. Janette A. Steets

2007-2008 Freshman Research Scholar Polymorphism in microsatellite loci in Impatiens capensis (Balsaminaceae)

Department of Botany, Oklahoma State University Supervisor: Dr. Janette A. Steets

Meador 6

ACADEMIC AWARDS Scholarships and Fellowships

2015-Present Arizona State University Dissertation Fellowship

2015-Present Philanthropic Education Organization Scholar

2011-Present National Science Foundation Graduate Research Fellow

2010-2011 Barry M. Goldwater Scholar

2010-2011 Anne Clark McHale Scholarship for Senior Women in Microbiology

2009-2010 Oklahoma State University Botany Scholarship

2008-2011 Class of 1942/Willham Library Scholar, Oklahoma State University Edmon Low Library

2008 Wentz Special Scholarship, Oklahoma State University

2007-2011 National Merit Scholar Institution Award, Oklahoma State University

2007-2011 Oklahoma State Regents for Higher Education Academic Scholar Tuition Waiver

2007-2011 Oklahoma State Regents for Higher Education Academic Scholar Cash Award

2007-2011 National Merit Dean’s Scholarship, Oklahoma State University

2007-2011 T.D. Williamson, Jr. Scholarship, T.D. Williamson, Inc.

2007-2008 Freshmen Research Scholarship, Oklahoma State University

2007-2008 Moose Association Scholarship, Women of the Moose Lodge

Awards and Recognition

2011 Arizona State University SUN Award

2011 Oklahoma State University Arts & Sciences Gonfalonier

2011 Oklahoma State University Top 10 Outstanding Senior

2010-2011 Oklahoma State University Arts & Sciences Top 10 Senior

2010-2011 Oklahoma State University Senior of Significance

2011 Division of Institutional Diversity Excellence in Achievement Award

2011 Dean’s Excellence Award for Student Assistants at the OSU Edmon Low Library

2011 V.G. Heller Award in Biochemistry & Molecular Biology

2010 Botanical Society of America Young Botanist Award

2010 Departmental Honors Award, OSU Dept. of Botany

2009-2010 Dan Wesley Outstanding Junior for OSU College of Arts & Sciences

2008-2009 Oklahoma State University Botany Department Outstanding Senior

2008 General Honors Award from OSU Honors College

Meador 7

2008 Oklahoma Academy of Sciences Technical Meeting Best Poster

2007-2011 Oklahoma State University President’s Honor Roll

2007-2008 Oklahoma State University Top 20 Freshmen Women

GRANT ACTIVITY Research Support

2015-2016 Graduate Research Support Program $2000

Graduate and Professional Student Association, Arizona State University

2010-2011 Wentz Research Scholar $4000

Office of Scholar Development, Oklahoma State University

2009 McPherson Fund Award $600

Department of Botany, Oklahoma State University

Summer 2009 Synthetic Biology REU $4000

National Science Foundation Grant, North Carolina State University

2009-2010 Niblack Research Scholar $8000

Office of Vice President for Research and Technology Transfer, Oklahoma State

University

2008-2009 Wentz Research Scholar $4000

Office of Scholar Development, Oklahoma State University

2007-2008 Freshman Research Scholar $500

Office of Scholar Development, Oklahoma State University

Travel Support

2015 Student Travel Award Biological Design, Ph.D. Program

2015 Women in Science Career Development Travel Award International Society for Antiviral Research

2014 Student Travel Award Graduate and Professional Student Association, Arizona State University

2013 Student Travel Award Graduate College, Arizona State University

2013 Student Travel Award Graduate and Professional Student Association, Arizona State University

2012 Student Travel Award Graduate College, Arizona State University

2012 Student Travel Award Graduate and Professional Student Association, Arizona State University

2012 Student Travel Award Biological Design Graduate Program, Arizona State University

Meador 8

2009 Frank & Mary Loewus Student Travel Award Phytochemistry Society of North America

ACTIVITIES AND SERVICE

Ad hoc Reviewer – Journals

Acta Biochimica Polonica

Departmental Service

Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University

2015 Volunteer, Night of the Open Door

2014 Tour guide, ASU Tempe Leadership Day

Biochemistry and Molecular Biology, Oklahoma State University

2009-2011 Member, Biochemistry Club

Microbiology, Oklahoma State University

2010-2011 Co-President, Microbiology Club

Botany, Oklahoma State University

2008-2009 Treasurer, Oklahoma State University Botanical Society

2007-2011 Member, Oklahoma State University Botanical Society

College Service

College of Arts & Sciences, Oklahoma State University

2010-2011 Delegate for College of Arts & Sciences, University Honors Council

2010-2011 Peer Mentor, College of Arts & Sciences

Institutional Service

Arizona State University

2013 & 2014 Organizer, Arizona State University Hands on Science Day sponsored by the Association for Women in Science

2012-Present Vice President, Association for Women in Science – Central Arizona Chapter

2012-2013 Peer Mentor, Shades Diversity Program

Fall 2011 Peer Reviewer, Graduate & Professional Student Association: Graduate Research Support Program

Fall 2011 Volunteer, Biodesign Institute Homecoming Outreach: Strawberry DNA Extraction

Meador 9

Oklahoma State University

Spring 2011 Attendee, Women for OSU Conference, Stillwater, OK

Summer 2010 Delegate, Golden Key International Conference, Scottsdale, AZ

Summer 2010 Volunteer, National Lab Day, Stillwater, OK

Spring 2010 Organizer, Golden Key International Honour Society Regional Summit, Stillwater, OK

Winter 2010 Brookhaven National Lab College Mini-Semester Program participant

2009-2011 Director of Membership Drive, Golden Key International Honour Society

2009-2011 Vice President, Golden Key International Honour Society

2009-2011 Member, Oklahoma Louis Stokes Alliance for Minority Participation in Science, Technology, Engineering, and Mathematics

Spring 2009 Host, Stout Hall Spring Preview for high school students

Spring 2009 Attendee, Golden Key International Honour Society Regional Conference, Dallas, TX

Fall 2009 Co-Chair, Stout Hall Homecoming Committee

2009-2010 Mentor, Girl Scouts High School Troop with Campus Girl Scouts

2008-2009 Executive for Recycling, Stout Hall Government

2008-2009 Member, Young Democrats

2007-2011 Secretary, Campus Girl Scouts

2007-2011 Member, Oklahoma State University Students Today Alumni Tomorrow

Spring 2008 Host, Stout Hall Spring Preview for high school students

Spring 2008 Secretary, Residence Hall Association Senate

2007-2008 Senator for Stout Hall, Residence Hall Association

2007-2008 Student Government Association Election Agency

2007 Founding Member, Campus Girl Scouts

Professional Service

2013 & 2014 Organizer, Association for Women in Science judging category at the Arizona Science and Engineering Fair, Phoenix, AZ

2012-2015 Judge, Arizona Science and Engineering Fair – Junior High Division, Phoenix, AZ

2012-2013 Vice President, Association for Women in Science, Central Arizona Chapter

Spring 2010 Volunteer, Society of Women Engineers Girl Scout Day

Spring 2008 Volunteer, Society of Women Engineers Girl Scout Day

Meador 10

Community Service

Spring 2012 Volunteer, Gilbert Water Festival 2012, Gilbert, AZ

Spring 2012 Participant, First Friday Art/Science Fusions

Spring 2010 Volunteer, Women in Science Conference, Oklahoma City, OK

Spring 2010 Volunteer, Habitat for Humanity Collegiate Challenge, Alamosa, CO

Spring 2010 Participant, Habitat for Humanity Shack-a-thon fundraiser

Spring 2009 Volunteer, Girl Scouts Thinking Day

Spring 2008 Participant, Habitat for Humanity Shack-a-thon fundraiser, Most Creative Award

PROFESSIONAL DEVELOPMENT

“Jumpstarting STEM Careers: Pathways to a Successful STEM Career.” Panel speakers in STEM and

Career Resources from various sources. Association for Women in Science. Tempe, AZ. 15

January 2016.

“Jumpstarting STEM Careers: Scientific Writing Symposium.” Elizabeth Pennisi (Science Magazine), Mary

Preap (Elsevier), and Clara Moskowitz (Scientific American). Association for Women in Science.

Tempe, AZ. 9 January 2015.

“Media attention in the sciences: the good, the bad, and the ugly.” Charles Arntzen. Association for

Women in Science. Tempe, AZ. 23 Oct. 2014.

“Tips on giving a great professional talk.” Patrick Cheung. Association for Women in Science. Tempe, AZ.

27 Nov. 2013.

“How to make visually compelling posters.” Patrick Cheung. Association for Women in Science. Tempe,

AZ. 20 Feb. 2013.

“Preparing for the Faculty Interview.” Duane Roen. Association for Women in Science. Tempe, AZ. 19

Sept. 2012.

“Preparing for the Academic Job Search.” Duane Roen. Strategies for Success. Arizona State University.

Tempe, AZ. 11 Sept. 2012.

Preparing Future Faculty, Year 1: Exploratory Phase. Arizona State University. 2012-2013.

The PFF program seeks to allow students to explore opportunities in academia while preparing

students to enter the job market with outstanding professional development. We attend

workshops and enlist advice of outside speakers while preparing crucial items of an application

or tenure packet.

“Funding: The Early Years – Grant Writing Workshop.” Faye Farmer. Association for Women in Science.

Tempe, AZ. 24 Apr. 2011.

“Writing an Elevator Speech.” Amanda Collins: The Grammar Doctor. Association for Women in Science.

Tempe, AZ. 15 Mar. 2011.

PROFESSIONAL AFFILIATIONS Association for Women in Science

Meador 11

International Society for Antiviral Research

American Society for Virology

International AIDS Society