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Curriculum Vitae William E. Grizzle, M.D., Ph.D.

UNIVERSITY OF ALABAMA AT BIRMINGHAM

SCHOOL OF MEDICINE

FACULTY CURRICULUM VITAE

PERSONAL INFORMATION Name: William E. Grizzle

Citizenship: USA

Home Address: 1992 Glen Cove

Homewood, Alabama 35209

Phone: (205) 942-2989

RANK/TITLE: Professor

DEPARTMENT: Pathology and Surgery

Business Address: 703 South 19th Street

Zeigler Building - Room 426

Birmingham, AL 35294-0007

Phone: (205) 934-4214

FAX: (205) 934-0816

E-Mail Address: [email protected]

HOSPITAL AND OTHER (NON ACADEMIC) APPOINTMENTS: 1971 Graduate Assistant Instructor, Department of Biophysics, Johns Hopkins University,

"Electronics for Research" (Biophysics 25.303)

1975 Postdoctoral Research Associate, Biomedical Engineering Department, Johns

Hopkins School of Medicine

1977-1979 Resident, Department of Pathology, Vanderbilt University School of Medicine

1979-1980 Resident, Department of Pathology, University of Alabama at Birmingham, Schools

of Medicine and Dentistry, Birmingham, AL

1981- Clinical Instructor, School of Health-Related Professions, Allied Health Department

and Cytotechnology Program, UAB

1981- Pathologist, Veterans Administration Medical Center, Birmingham, Alabama

1981-1985 Assistant Professor, Department of Pathology, UAB

1983- Senior Scientist and Director, Tissue Procurement Service, Comprehensive Cancer

Center, UAB

1985-1989 Associate Professor, Department of Pathology, UAB

1987- Director, Southern Division, National Cancer Institute, Cooperative Human Tissue

Network

1989- Professor, Department of Pathology, UAB

1990-2000 Head, Autopsy Service, Department of Pathology, UAB and Veteran’s Hospital,

Birmingham

2005 - Adjunct Professor of Urology, Emory University Medical School

2017- Professor, Department of Surgery, UAB


EDUCATION: Institution Degree Year

Harvard University B.A., Chemistry and 1965

Physics

Bettis Atomic Power Laboratory Certificate in Nuclear 1967

Reactor Engineering School, Engineering

Westinghouse

Georgetown University (all but dissertation ABD

completed for M.S.

in Physics)

Johns Hopkins University Ph.D., Biophysics 1975

Johns Hopkins University M.D. 1977

School of Medicine

MILITARY SERVICE:

1965-1970 Naval Officer (03), assigned to staff (Radiation Health Physics) of Admiral

Hyman G. Rickover in Division of Naval Reactors, U.S. Atomic Energy

Commission; Honorable Discharge

LICENSURE:

1980 State of Alabama, Number 9454

BOARD CERTIFICATION:

1980 FLEX

1982 American Board of Pathology, Anatomical and Clinical, Diplomate

POSTDOCTORAL TRAINING:

Year Degree Institution

1975 Postdoctoral Research Associate, Johns Hopkins University

Biomedical Engineering Department School of Medicine

AWARDS/HONORS/COMMITTEES:

1961-1965 NROTC Full Scholarship, Harvard University

1965 Honors Degree, Harvard University

1970-1974 NIH Graduate Fellowship, Johns Hopkins University,

Department of Biophysics

1976 Henry Strong Denison Scholarship for Excellence in Biomedical Research,

Johns Hopkins School of Medicine

1988-1991 College of America Pathologists (CAP)– House of Delegates, Alternate

Delegate, Alabama

1980 CAP – Commission on Laboratory Accreditation, Inspector

1985 CAP – Faculty, Inspection Workshops

1984-1985 Best Pathology Consultant, Medical-Pathology Conference, University of


Alabama at Birmingham

1987-1991 Committee on Markers of Exposure to Toxic Substances:

National Monitoring of Human Tissue, National Research Council

National Academy of Science

1988-1990 House of Delegates, College of American Pathologists, Alternate

Delegate Alabama

1991-1993 Peer Review Committee - American Heart Association, Alabama Affiliate

1996-1997 Ad Hoc Committee, American Society for Investigative Pathology

1995 Resident Teaching Award

1996-2000 Biological Stain Commission – Vice President

2000-2004 Biological Stain Commission – President

1996-2001 Associate Director, Oral Cancer Biology Center, UAB

1996-1998 Ad Hoc Committee, College of American Pathologists, Requirements for the

Use of Human Tissues in Research

1997-2000 Committee to Establish the International Society of Biological and

Environmental Resources (ISBER) - an organization focusing on use of

human and animal tissues in research; Organizing Board.

2000-2003 Board of Directors ISBER

2000-2002 Chairman – Genitourinary Group – Early Detection Research Network (EDRN)

2003-2003 Co-Chair Minisymposium entitled “Proteomics and Novel Technologies for

diagnosis and Early Detection at AACR 9th

Annual Meeting, Washington, DC.

2004-2005 President Elect– The International Society for Biological and Environmental

Repositories (ISBER)

2005-2006 President – The International Society for Biological and Environmental

Repositories (ISBER)

2006-2007 Nominating Committee Chair, The International Society for Biological and

Environmental Repositories (ISBER)

2006-2008 Member, Scientific Advisory Board, BioLife Solutions.

2006-Current Member, Steering Committee for Pulmonary Hypertension Breakthrough

Initiative (PHBI)

2006-Current Member, Tissue Utiliztion Committee for PHBI

2007 Consultant, Cancer Therapy & Research Center (CTRC), The University of Texas

Health Science at San Antonio

2007-2008 Chair, CHTN Coordinating Committee (begins 2007)

2007-2008 NCI - Leadership Award in Translational Research and in the Early Detection

Rewearch Network.

1984-Current Consultant, Division of Cancer Biology and Diagnosis, National Cancer

Institute

Reviewer (ad hoc) Study Sections, National Cancer Institute

Reviewer for the American Journal of Medicine, Archives of Pathology and

Laboratory Medicine, the American Journal of Medical Sciences, Cancer

Research, Endocrinology, Journal of Histotechnology, Journal of

Nutrition, Biotechnic and Histotechnology, Journal of Urology, American

Journal of Physiology

1987-Current Member, Coordinating Committee, National Cancer Institute’s Cooperative

Human Tissue Network (CHTN)

1993-Current Southwest Oncology Group, GU Pathology Committee

1992-Current Editorial Board, Journal of Histotechnology

1993-Current Southwest Oncology Group; GU Pathology Committee

1992-Current Elected Member, Biological Stain Commission


1993-2017 Biological Stain Commission – Trustee

1996-Current Advisory Committee to the Director, National Cancer Institute, Developmental

Diagnostics Working Group - Development of Clinical Resources

1998-Current College of American Pathologists - Ad Hoc Committee on Genetics and Medical

Information Privacy

2002-2006 Executive Committee – Early Detection Research Network (EDRN)

2007-2009 Member, Oversight Committee, Interspore Prostate Biomarker Study (IPBS),

Johns Hopkins University

2007-2009 Consultant, Kirkwood Guild Melanoma Tissue Repository

2008-Current Consultant, Genitourinary Research Center and the Prostate SPORE, M. D.

Anderson Cancer Center

2008-Current UT M. D. Anderson Cancer Center, Division of Cancer Medicine, Department of

Genitourinary Medical Oncology, David Koch Center for Applied Research of

Genitourinary Cancers Advisory Board

2008- 2010 Consultant, Ad Hoc IPBS (Inter-SPORE Prostate Biomarker Study) Oversight

Committee

2008-Current Chair, ACRIN NLST Biomarker Oversight Committee

2009-Current Member, Program Steering Committee on Bioethics, Morehouse School of

Medicine/Tuskegee University/UAB Cancer Partnership

2010-2011 NCI - Leadership Award in Translational Research and in the Early Detection

Rewearch Network.

2010-2014 Consultant to the Prostate Cancer Pathology Resource Network (PCPRN)

2010-Current Member, The Cancer Genome Atlas (TCGA) Breast Disease Working Group

2010-Current Pathology Reviewer (Breast), The Cancer Genome Atlas (TCGA) Project

2010-Current Member, External Advisory Board, Biospecimen Shared Resource Facility,

Kansas University Cancer Center

2010-2014 External Advisor, Steering Committee, Prostate Cancer Biomarker Network

(PCBN), Johns Hopkins University

2011-2014 External Advisory Committee for the Department of Defense Lung Cancer

Biospecimen Resource Network (LCBRN)

2011-Current Member, Breast Pathology Expert Pathology Committee of the Cancer Genome

Atlas (TCGA) Project

Previous Consultant in Tissue Resources for the National Heart, Lung and Blood Institute

of the National Institutes of Health

2010-Current Consultant in Tissue Resoruces for the National Institute of Arthritis and

Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health

2011-Current Consultant in Tissue Resources for the Canadian Tumour Repository Network

(CTRNet).

2011-Current Consultant, SSIP Public Affairs Focus Group focused on the ANPRM on Human

Subjects Research Protections

2012-Current Member, the ISBER Science Policy Committee

2012-Current Associate Editor for Cancer Biomarkers

2014-2017 Consultant and Member of the External Advisory Board of the DOD Prostate

Cancer Biorepository Network (PCBN)

2015 ISBER Award for Outstanding Achievement in Biobanking

2017-Current Biological Stain Commission - Trustee Emeritus

2019 ISBER Founder’s Award

NATIONAL/INTERNATIONAL ORGANIZATIONAL ACTIVITIES:


March 2004 Organized the EDRN Biostatistical (SELDI-MALDI) workshop at Fred

Hutchinson Cancer Center, March 15-20, 2004, Seattle, WA.

March 2004 Co-Chair, Symposium Session: Molecular Profiling and Computer Modeling in

Early Detection and Treatment of Cancer, The Society of Toxicology 43rd

Annual

Meeting, March 21-25, 2004, Baltimore, MD.

PROFESSIONAL SOCIETIES:

Past Member American Diabetes Association

Past Member American Society of Cytology, Fellow

Past Member American Society of Clinical Pathologists, Fellow

Past Member American Association for Clinical Chemistry

Past Member Clinical Ligand Assay Society

Past Member College of American Pathologists, Fellow

Past Member Endocrine Society

Current Member International Academy of Pathology

Current Member Alabama Society for Histotechnology (Honorary)

Current Member National Society for Histotechnology

Current Member Biological Stain Commission

Current Member International Society for Biological and Environmental Repositories

Current Member American Association for Cancer Research

MEMBERSHIPS: (Memberships are listed in Societies or Awards and Honors, previous two

categories.)

COUNCILS AND COMMITTEES:

UNIVERSITY ACTIVITIES:

1975-1977 Curriculum Committee, Johns Hopkins University School of Medicine

1991-1992 Co-Chairman, Committee for the Examination of the Autopsy

1981-1983 Chairman, Residency Committee, Department of Pathology, University of

Alabama at Birmingham,

Member, 1980-1981; 1986-1993

1982-1991 Teaching Committee, Department of Pathology, UAB

1983-1993 Research Committee, Department of Pathology, UAB

1984-1985 Chairman, Research Review Committee, Department of Pathology UAB

1984-1985 Graduate School Council

1984-1993 Graduate Committee, Department of Pathology

1984-1988 Tumor Committee, Birmingham Veterans Administration Medical Center

1985-1989 Animal Research Use Committee, Birmingham Veterans Administration

Medical Center

1991-1995 Medical Education Task Force Committee, University of Alabama System

Medical Education Committee, UAB

1991-1995 Chairman, Assessment Committee, University of Alabama System Medical

Education Committee, UAB

1991-1995 Basic Sciences Committee, University of Alabama System Medical Education

Committee, UAB

1991-1993 Patient/Problem-Based Learning Committee, University of Alabama System

Medical Education Committee, UAB

1991-1992 Chairman, Genitourinary Research Working Group


1995-1997 Medical and Dental Basic Sciences Advisory Committee,

Chair, Subcommittee on the Definition of Tenure

1996-1998 Pathology Department Advisory Committee

1986-2007 Institutional Review Board - Human Use, UAB

1996-2001 Associate Director, Oral Cancer Biology Center, UAB

1996-2001 Head and Neck Cancer Working Group

1999-2000 Hospital Utilization Committee

1999-2000 Clinical Studies Review Committee - Comprehensive Cancer Center

1999-2000 Gastrointestinal Tumor Working Group

1999-2001 UAB Faculty Senate Alternate; 2000-Current – Finance Committee

2000-2002 Joint Health Sciences Faculty Status Committee

2000-2005 Steering Committee, UAB Ovarian SPORE

2000-2001 Head, HIPAA Committee on Research

2001 NCI Co-Chair, Commercial Data Elements Committee for Breast Cancer

2002-2008 Steering Committee, UAB Pancreatic SPORE

2003-2005 School of Medicine/Dentistry Joint Health Sciences Faculty Status Committee

2004-2005 Member, Multidisciplinary Advisory Committee (MAC)

1987-2009 Chair, CHTN Regulatory Affairs Subcommittee

1996-2009 Chair, CHTN Bioinformatics Subcommittee

1989-Current Cancer Committee

1993-Current Genitourinary Clinical Working Group

1993-Current Chemoprevention Committee, Comprehensive Cancer Center

2000-Current Associate Scientist – UAB Clinical Nutrition Research Center

2001-Current Executive Committee, UAB Breast SPORE

2000-Current Head of the Program of Translational Research in Neoplasia, Pathology, UAB

2005-Current Senior Scientist, Center for Aging

2005-Current HIPAA Steering Committee, University and Health Services Foundation

2004-Current Co-Director, GU Clinical Research Center, UAB

2011-Current Member, Internal Advisory Committee for T32 Research Training Program in

Surgical Oncology

EDITORIAL BOARD MEMBERSHIPS:

Past International Journal of Cancer (1995-2009)

Past Laboratory Investigation

Past Clinical, Cosmetic and Investigational Dermatology

Past Research Trends (2004-2008)

Current Cell Preservation Technology (2006-current)

Current Biotechnic and Histotechnology (1994-current)

Current Journal of Histotechnology

Current Clinical Cancer Research

Current Current Cancer Therapy Reviews

Current Cancer Informatics

Current Journal of Cancer Science and Therapy

Current Breast Cancer: Basic and Clinical Research

Current Cell Preservation Technology

Current Human Genomics and Proteomics (2008-current)

Current Cancer Biomarkers

Current Clinical Cancer Research

Current Translational Andrology and Urology (2018-current)


OTHER:

Current Postdoctoral Fellows/Faculty:

Russell B. Myers, Ph.D. - 1991 –2000

Muio M. Arnold, Ph.D - 1993 - 1994

Cecilia Moran, M.D. - 1994

G. Dean Roye, M.D. - 1995-1996

Omar K. Danner, M.D. - 1995

Philip Roland, M.D. - 1996- 1997

Stephenie Dillard, M.D. - 1996 –1997

Helen Krontiras, M.D. - 1996 –1997

Cristina Rodriguez-Burford, Ph.D. - 1999 – 2001

Upender Manne, Ph.D. - 1995 – 2000

David Brown, Ph.D. - 1997

Andra R. Frost, M.D. - 1997 – 2000

Walter C. Bell, M.D. - 2000 – current

Chandrika Piyathilake, Ph.D. - 1997-2000

Scott Magnuson, M.D. - 1998-1999

Mark Gibbons, M.D. - 1999

Lynya Talley, Ph.D. - 1999-2000

Cheung F. (David) Chheng, M.D. - 1999-2008

Isam-Eldin Eltoum, M.D. - 2000 – 2005

Darshana N. Jhala, M.D. - 2000 - 2005

Nirag Jhala, M.D. - 2000 – current

Katrin M. Klemm, M.D. - 2001- 2003

Maria Azrad, Ph.D. - 2001-2005

Victor S. Vital-Reyes, M.D. - 2002-2005

Maximo A. Benavides, M.D. - 2003-2005

Wen Yang, M.D. - 2004 - 2006

Dennis Otali, Ph.D. - 2005 – 2007, 2009 - 2018

Hadiyah Green, Ph.D. 2005-2013

Omar Hameed, M.D. - 2006 - ________

Piotr Kulesza, M.D, - 2006 - 2009

Patricia DeVilliers, DDS - 2009 -_________

Jacqueline Jones, Ph.D. - 2009-2012

Shi Wei, M.D. - 2010 - 2014

Evrim Gurpinar, Ph.D. - 2011-2013

Elizabeth Hanson-Kerr, M.D. - 2005-2007

Lacey R. McNally, Ph.D. - 2005-current

Matthew N. Alder, M.D., Ph.D. - 2006-2009

Derrick M. Huffman, Ph.D. - 2007

Heather Nicole Tinsley, Ph.D. - 2007-2010

Qinghua (Peter) He, Ph.D. - 2010-2011

Liz Simon, Ph.D. - 2011-2012

Nan Li, Ph.D. - 2013-2014

Christos Vaklavas 2014-current

Clayton Yates - 2012-current

Daniel S. Atherton - 2014-current

Mick Edmonds, Ph.D. - 2018-current

Sameer Al-Diffalha, M.D. - 2018-current

Honghe Wang, Ph.D. - 2018-current


EDUCATIONAL EXPERIENCE Teaching Experience

• Member of Curriculum Committee, Johns Hopkins University Medical School,

1975-1977

• Medical students’ endocrine pathophysiology at Vanderbilt and UAB 1977

• Coursemaster - endocrine pathophysiology, UAB, 1983-1996

• Faculty endocrine pathophysiology, 1981-2008

• Member of UAB Department of Pathology Education Committee, 1982-1991

• Member of the University of Alabama at Birmingham Medical Education

Committee

• Chairman of the Assessment Subcommittee of the UAB Medical Education

Committee, 1991-95

• Executive Board, Medical Education Committee, 1992-95


BIBLIOGRAPHY

MANUSCRIPTS

Manuscripts already published

1. Levy II H, Grizzle WE. Wide-line NMR Study of Molecular Motion in

Me3[SiNSiMe3]2. J Chem Physics 1966; 45:1954-61.

2. Grizzle WE, Dallman MF, Schramm LP, Gann DS. Inhibitory and Facilitory

Hypothalamic Areas Mediating ACTH Release in the Cat. Endocrinology 1974;

95(5):1450-61.

3. Grizzle WE, Johnson RN, Schramm LP, Gann DS. Hypothalamic Cells in the Area

Mediating ACTH Release Respond Right Atrial Stretch. Am J Physiol 1975;

228(4)1039-45.

4. Ward DG, Grizzle WE, Gann DS. Inhibitory and Facilitory Areas of the Rostral Pons

Mediating ACTH Release in the Cat. Endocrinology 1976; 99(5):1220-28.

5. Maran JW, Carlson DE, Grizzle WE, Ward DG, Gann DS. Organization of the

Hypothalamus for Control of Adrenocorticotropin in the Cat. Endocrinology

1978;103(3):957-70.

6. Grizzle WE, Johnson KH. Membranous Nephropathy in a Renal Allograft. Its

Occurrence With Previous Anti-Glomerular Basement Membrane Disease. Arch Pathol

Lab Med 198l; l05(2):7l-75

7. Rubin KE, Grizzle WE. Radiology rounds: Fever of Unknown Origin in a 48-Year Old

Man Seven Years After Mesocaval Shunt. Ala J Med Sci 1982;19(3):289-95

8. Crowell W, Grizzle WE, Siegel AL. Functional Carotid Paragangliomas: Biochemical,

Ultrastructural and Histochemical Correlation with Clinical Symptoms. Arch Pathol Lab

Med 1982;l06(12):599-603

9. Phillips J, Orr JW, Grizzle W, Hatch KD. An Extra-adrenal Pheochromocytoma

Mimicking Lymph Node Metastasis from a Cervical Cancer. Gynecol Oncol

1982;13(3):416-22

10. Orr JW, Grizzle WE, Huddleston JF. Squamous Cell Carcinoma Metastatic to the

Placenta and Ovary. Obstet Gynecol 1982;59( 6 Suppl):8lS-83S

11. Ketchum CH, Robinson CA, Hall LM, Grizzle WE, Maclaren NK, Riley WJ, Trost C.

Clinical Significance and Partial Biochemical Characterization of Lactate Dehydrogenase

Isoenzyme 6. Clin Chem 1984;30(1):46-49

12. Herrera GA, De Moraes HP, Grizzle WE, Han SG. Malignant Small Bowel Neoplasm

of Enteric Plexus Derivation (Plexosarcoma) Light and Electron Microscopic Study

Confirming the Origin of the Neoplasm. Dig Dis Sci 1984;29(3):275-84


13. Grizzle WE, Dunlap NE. Aldosterone Blocks Adrenal Compensatory Hypertrophy in

the Rat. Am J Physiol 1984;246(4 Pt 1):E306-10

14. Dunlap NE, Grizzle WE. Golden Syrian Hamsters: A New Experimental Model for

Adrenal Compensatory Hypertrophy. Endocrinology 1984;114(5):1490-95

15. Grizzle WE, Tolbert L, Pittman CS, Siegel AL, Aldrete JS. Corticotropin Production by

Tumors of the Autonomic Nervous System. Arch Pathol Lab Med 1984;108(7):545-50

16. Robinson Jr CA, Ketchum CH, Grizzle WE, Hall LM, Alexander CB. Abnormal Lactate

Dehydrogenase Isoenzyme Pattern in a Critically Ill Patient. South Med J

1984;77(7):921-23

17. Ketchum CH, Robinson Jr CA, Hall LM, Grizzle WE. LD-6 Isoenzyme and Lactat-

Independent Dehydrogenase Differ. Clin Chem 1984;30(7):1269-71

18. Pino JA, Gaitan E, Grizzle WE. Resistencia a La Insulina, Acanthosis Nigricans Y

Escleredema Diabeticorum. Acta Medica Colombiana 1984;9:341-45

19. Herrera GA, Garceau PA, Grizzle WE. Glucagon Producing Islet Cell Tumors. Am Soc

Clin Pathol Check Sample 1984 AP84-ll

20. Dunlap NE, Grizzle WE, Siegel AL. Cushing's syndrome: Screening Methods in

Hospitalized Patients. Arch Pathol Lab Med 1985;109(3):222-229

21. Prasthofer EF, Prchal JT, Grizzle WE, Grossi CE. Plasmacytoid T-cell Lymphoma

Associated with Chronic Myeloproliferative Disorder. Am J Surg Pathol 1985;9(5):380-

87

22. Grizzle WE, Dunlap NE, Stabler TV. A Commercially Available Assay Kit for

Determining Aldosterone Concentration in Non-Extracted Rat Serum. Lab Anim Sci

1985;35(4):387-91

23. Grizzle WE. Pheochromocytomas. Clin Chem News 1985;11(12):6-7

24. Stabler TV, Grizzle WE, Howell WH. Non-Resolving Cushing's Syndrome Secondary

to Depot Methylprednisolone Verified by High-Performance Liquid Chromatography.

South Med J 1985;78(9):1143-44

25. Wurster-Hill DH, Noll WW, Bircher LY, Pettengill OS, Grizzle WE. Cytogenetics of

Medullary Carcinoma of the Thyroid. Cancer Genet Cytogenet 1986;20(3-4):247-53

26. Staples TC, Grizzle WE. A Methyl Green Nuclear Stain for Argyrophil Procedures.

Lab Med 1986;17(9):532-534

27. Kheir SM, Omura E, Grizzle WE, Herrera GA. Histologic Variation in the Skin Lesions

of the Glucagonoma Syndrome. Am J Surg Pathol 1986;l0(7):445-453

28. Gandour MJ, Grizzle WE. A Small Adrenocortical Carcinoma with Aggressive


Behavior. An evaluation of criteria for malignancy. Arch Pathol Lab Med

1986;110(11):l076-l079

29. Chastain SL, Ketchum CH, Grizzle WE. Atypical Creatine Kinase Migrating with

CKMB. J Am Med Assoc 1986;256:1035-l036

30. Staples TC, Grizzle WE. Effect of Temperature on Arygrophilic Impregnation with

Development of a High Temperature, Rapid Argyrophil Procedure. Stain Technol

1987;62(1):41-49

31. Dustan HP, Stanley RJ, Grizzle WE, Brand JW. Medical Pathology Conference: A 35-

Year Old Black Woman with Hypokalemia and Accelerated Hypertension. Ala J Med

Sci 1987;24(1):31-40

32. Kennedy JI, Chandler DB, Fulmer JD, Wert MB, Grizzle WE. Effects of Dietary Fats

on Bleomycin-Induced Pulmonary Fibrosis. Exp Lung Res 1987;12(2):149-16l

33. Stinnett B, Rodu B, Grizzle WE. New Developments in Understanding Phenytoin-

Induced Gingival Hyperplasia. J Am Dent Assoc 1987;114(6):814-816. Reprinted:

Year Book Dent 1988

34. Forrester K, Almoguera KC, Han K, Grizzle WE, Perucho M. Detection of High

Incidence of K-ras Oncogenes During Human Colon Tumorigenesis. Nature

1987;327(6120):298-303

35. Clausen KC, Grizzle WE, LiVolsi VA, Newton WE. Availability of Human Tissues for

Research in Cancer. Science 1987;237(4810):10-11

36. Grizzle WE. The Nuts and Bolts of Quality Assurance in Anatomic Pathology. Ala Soc

Histotechnol 1987;12(3):1-2,12(4):1-2

37. Forrester K, Almoguera KC, Jordano J, Grizzle WE, Perucho M. High Incidence of C-

K-RAS Oncogenes in Human Colon Cancer Detected by the RNAse A Mismatch

Cleavage Method. J Tumor Marker Onc;1987:2(3):113-122

38. Chandler DB, Barton JC, Briggs III DD, Butler TW, Kennedy JJ, Grizzle WE, Fulmer

JD. Effect of Iron Deficiency in Bleomycin-Induced Lung Fibrosis in the Hamster. Am

Rev Respir Dis 1988;137(1):85-89

39. Chandler DB, Butler TW, Briggs DD, Grizzle WE, Barton JC, Fulmer JD. Modulation

of the Development of Bleomycin-Induced Fibrosis by Deferoxamine. Toxicol Appl

Pharmacol 1988;92(3):358-367

40. Jenkins RL, McDaniel HG, Grizzle W, Parrish SW, McDaniel HB. Demonstration of

the Adnosine Reservoirs with Nitrobenzylthioinosine in Liver and Diaphragm by High-

Performance Liquid Chromatography. J Chromatogr 1988;426(2):249-258

41. Ryan WG, Grizzle WE. Methods of Measuring Thyroid Hormone Levels. Am J

Psychiatry 1988;145(2):266


42. Chastain SL, Ketchum CH, Grizzle WE. Stability and Electrophoretic Characteristics of

Creatine Kinase BB Extracted from Human Brain and Intestine. Clin Chem

1988;34(3):489-492

43. Kenney P, Pittman CS, Grizzle WE, Crossly C. Tachybrady-Arrhythmias and "Spells" in

a 47 Year Old Man. Ala J Med Sci 1988;25(2):151-158

44. Ketchum CH, Robinson Jr CA, Hall LM, Grizzle WE. Lactate Dehydrogenase Isolated

from Human Liver Mitochondria: Its Purification and Partial Biochemical

Characterization. Clin Biochem 1988;21(4):231-237

45. Pillion DJ, Yang M, Grizzle WE. Distribution of Receptors for Insulin and Insulin-Like

Growth Factor I (Somatomedin C) in the Adrenal Gland. Biochem Biophys Res

Commun 1988;154(1):138-145

46. Pillion DJ, Jenkins R, Atchison JA, Stockard CR, Clements RS, Grizzle WE.

Paradoxical Organ-Specific Adaptations to Streptozotocin Diabetes Mellitus in Adult

Rats. Am J Physiol 1988;254(6 Pt 1):E749-E755

47. Grizzle WE. Pathology of the Adrenal Gland. Semin Roentgenol 1988;23(4):323-331

48. Atchison JA, Grizzle WE, Pillion DJ. The Effect of Haemolysis on Radioimmunoassay

for Insulin. Diabetalogia 1988;31(6):403-404

49. Turbat-Herrera EA, Herrera GA, Gore I, Lott RA, Grizzle WE, Bonnin JM.

Neuroendocrine Differentiation in Prostatic Carcinomas. A retrospective autopsy study.

Arch Pathol Lab Med 1988;112(11):1100-1105

50. Grizzle WE, Polt SS. Guidelines to Avoid Personnel Contamination by Infective Agents

in Research Laboratories that Use Human Tissues. J Tissue Culture Method

1988;11(4)19l-200

51. Walter-Ryan WG, Pittman CS, Grizzle WE. Lithium Treatment of Hyperthyroidism. J

Clin Psychiat 1988;49(4)170

52. Dunlap NE, Grizzle WE, Heck Jr LW. Unsuspected Cushing's Disease in Patient with

Fatal Staphylococcal Bacteremia and Multiple Pituitary Adenomas. Am J Med

1989;86(2):217-21

53. Clausen KP, Grizzle WE, Livolsi V, Newton WA, Aamodt R. The Cooperative Human

Tissue Network. Cancer 1989;63(7):1452-1455

54. Atchison JA, Grizzle WE, Pillion DJ. Colonic Absorption of Insulin: An in vitro and in

vivo Evaluation. J Pharmacol Exp Ther 1989;248(2):567-572

55. Pace C, Goldsmith K, Delmo C, Grizzle W, Bucy RP. Functional and Morphological

Studies of Long-Term Islet Allografts in the Renal Subcapsular Space of the BB/W Rat.

Transplantation 1989;47(4):580-582

56. Grizzle WE, Dunlap NE. Cushing's Syndrome: Diagnosis of the Atypical Patient. Arch


Pathol Lab Med 1989;113(7):727-728

57. Herrera GA, Cerezo L, Jones JE, Sack J, Grizzle WE, Pollack WJ, Lott RL.

Gastrointestinal Autonomic Nerve Tumors 'Plexosarcomas'. Arch Pathol Lab Med

1989;113(8):846-853

58. Pillion DJ, Arnold P, Yang M, Stockard CR, Grizzle WE. Receptors for Insulin and

Insulin-Like Growth Factor-1 in the Human Adrenal Gland. Biochem Biophy Res

Commun 1989;165(1):204-211.

59. Alvarez RD, Grizzle WE, Smith LJ, Miller DM. Compensatory Ovarian Hypertrophy

Occurs by a Mechanism Distinct from Compensatory Growth in the Regenerating Liver.

Am J Obstet Gynecol 1989;161(6 Pt 1):1653-1657.

60. Perucho M, Forrester K, Almoguera C, Kahn S, Lama C, Shibata D, Arnheim N, Grizzle

WE. Expression and Mutational Activation of the c-Ki-ras Gene in Human Carcinomas.

Cancer Cells 1989;7:137-141.

61. Kennedy JI, Chandler DB, Fulmer JD, Wert MB, Grizzle WE. Dietary Fish Oil Inhibits

Bleomycin-Induced Pulmonary Fibrosis in the Rat. Exp Lung Res 1989;15(2):315-329.

62. Allard MF, DeVenny MF, Doss LK, Grizzle WE, Bishop SP. Alterations in Dietary

Sodium Affect Isoproterenol-Induced Cardiac Hypertrophy. J Mol Cell Cardiol 1990;

22(10):1135-1145.

63. Bookstein R, Rio P, Madreperla SA, Hong F, Allred C, Grizzle WE, Lee WH. Promoter

Deletion and Loss of Retinoblastoma Gene Expression in Human Prostate Carcinoma.

Proc Natl Acad Sci 1990; 87 (19):7762-6.

64. Kwakye JB, Johnson MR, Barnes S, Grizzle WE, Diasio RB. Identification of Bile Acid

CoA: Amino Acid N-Acyltransferase in Rat Kidney. Biochem J 1991; 280 (Pt 3):821-

824.

65. Pillion DJ, Bartlett JD, Meezan E, Yang M, Crain RJ, Grizzle WE. Systemic Absorption

of Insulin Delivered Topically to the Rat Eye. Invest Opthalmol Vis Sci 1991;

32(12):3021-3027.

66. Saleh MN, Khazaeli MB, Wheeler RH, Allen L, Tilden AB, Grizzle W, Reisfeld RA, Yu

AL, Gillies SD, LoBuglio AF. Phase I Trial of the Chimeric Anti-GD2 Monoclonal

Antibody ch14.18 in Patients with Malignant Melanoma. Hum Antibodies Hybridomas

1992; 3(1):19-24.

67. LiVolsi VA, Clausen K, Grizzle W, Newton W, Pretlow TG, Aamodt R. The

Cooperative Human Tissue Network: An Update. Cancer 1993; 71(4):1391-1394.

68. Saleh MN, Khazaeli MB, Grizzle WE, Wheeler RH, Lawson S, Liu T, Russell C,

Meredith R, Schlom J, LoBuglio AF. A Phase 1 Clinical Trial of Murine Monoclonal

Antibody D612 in Patients with Metastatic Gastrointestinal Cancer. Cancer Res 1993;

53(19):4555-4562.


69. Royal M, Grizzle WE, Algermissen V, Mowry RW. The Success of a Clinical Librarian

Program in an Academic Autopsy Pathology Service. Am J Clin Pathol 1993; 99(5):576-

581.

70. Pillion DJ, Grizzle WE, Yang M, Meezan E, Stockard CR, Ganapathy V, Leibach FH,

Myers RB, Haskell JF. Expression of IGF-II/Man-6-P Receptors on Rat, Rabbit and

Human Colon Epithelial Cells. Am J Physiol 1993; 264(6 Pt 2):R1101-R1110.

71. Meredith RF, Khazaeli MB, Grizzle WE, Orr RA, Plott G, Urist MM, Liu T, Russell

CD, Wheeler RH, Schlom J, LoBuglio AF. Direct Localization Comparison of Murine

and Chimeric B72.3 Antibodies in Patients with Colon Cancer. Hum Antibodies

Hybridomas 1993; 4(4):190-197.

72. Myers RB, Kudlow JE, Grizzle WE. Expression of Transforming Growth Factor-Alpha,

Epidermal Growth Factor and the Epidermal Growth Factor Receptor in Adenocarcinoma

of the Prostate and Benign Prostatic Hyperplasia. Mod Pathol 1993; 6(6):733-737.

73. Myers RB, Srivastava S, Oelschlager DK, Grizzle WE. Expression of p160erbB-3

and

p185erbB-2

in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma. J Natl

Cancer Inst 1994; 86(15):1140-1145.

74. Myers RB, Meredith RF, Schlom J, LoBuglio AF, Bueschen AJ, Wheeler RH, Stockard

CR, Grizzle WE. Tumor Associated Glycoprotein-72 is Highly Expressed in Prostatic

Adenocarcinomas. J Urol 1994; 152(1):243-246.

75. Grizzle WE, Myers RB, Arnold MM, Srivastava S. Evaluation of Biomarkers in Breast

and Prostate Cancer. J Cell Biochem 1994 ;( Suppl) 19:259-266.

76. Beenken S, Huang P, Sellers M, Peters G, Listinsky C, Stockard C, Hubbard W, Wheeler

R, Grizzle WE. Retinoid Modulation of Biomarkers in Oral Leukoplakia/Dysplasia. J

Cell Biochem 1994 ;(Suppl)19:270-277.

77. Parker CR, Falany CN, Stockard CR, Stankovic AK, Grizzle WE.

Immunohistochemical Localization of Dehydroepiandrosterone Sulfotransferase in

Human Fetal Tissues. J Clin Endocrinol Metab 1994; 78(1):234-236.

78. Myers RB, Parker MW, Grizzle WE. The Effects of Coumarin and Suramin on the

Growth of Malignant Renal and Prostatic Cell Lines. J Cancer Res Clin Oncol, Springer-

Verlag 1994:120(Suppl):S11-S13.

79. Grizzle WE, Phelan ST. Thyroid Dysfunction in Nonpregnant Women. Prim Care

Update Ob-Gyns 1994; 1(1):45-54.

80. Meredith RF, Bueschen AJ, Khazaeli MB, Plott WE, Grizzle WE, Wheeler RH, Schlom

J, Russell CD, Liu T, LoBuglio AF. Treatment of Metastatic Prostate Cancer with

Radiolabeled Antibody CC49. J Nucl Med 1994; 35(6):1017-1022.

81. Bostwick DG, Burke HB, Wheeler TM, Chung LWK, Bookstein R, Pretlow TG, Nagle

RB, Montironi R, Lieber MM, Veltri RW, Grizzle WE, Grignon DJ. The Most

Promising Surrogate Endpoint Biomarkers for Screening Candidate Chemopreventive


Compounds for Prostatic Adenocarcinoma in Short-Term Phase II Clinical Trials. J Cell

Biochem 1994 ;( Suppl) 19:283-289.

82. Myers RB, Oelschlager D, Srivastava S, Grizzle WE. Accumulation of the p53 Protein

Occurs More Frequently in Metastatic than in Localized Prostatic Adenocarcinomas.

Prostate 1994; 25(5):243-248.

83. Stankovic AK, Grizzle WE, Stockard CR, Parker CR. Interactions Between

Transforming Growth Factor β and Adrenocorticotropin in Growth Regulation of Human

Adrenal Fetal Zone Cells. Am J Physiol 1994; 266(3 Pt1):E495-E500.

84. Garg A, Grizzle WE, Kansal PC, Stabler TV, Boots LR. Counter-Regulatory Hormone

Responses to Insulin-Induced Acute Hypoglycemia in Hypopituitary Patients. Horm

Metab Res 1994; 26(6):276-282.

85. Ryan WG, Roddam RF, Grizzle WE. Thyroid Function Screening in Newly Admitted

Psychiatric Inpatients. Ann Clin Psychiatry 1994; 6(1):7-12.

86. Kakar SS, Grizzle WE, Neill JD. The Nucleotide Sequences of Human GnRH Receptors

in Breast and Ovarian Tumors are Identical with that Found in Pituitary. Mol Cell

Endocrinol 1994; 106(1-2):145-149.

87. Grizzle WE, Phelan ST. Evaluation of Thyroid Nodules: Clinical Considerations. Prim

Care Update Ob-Gyns 1994; 1(4):161-167.

88. Myers RB, Srivastava S, Grizzle WE. Lewis Y Antigen as Detected by the Monoclonal

Antibody BR96 is Expressed Strongly in Prostatic Adenocarcinoma. J Urol 1995;

153(5):1572-1574.

89. Myers RB, Schlom J, Srivastava S, Grizzle WE. Expression of Tumor-Associated

Glycoprotein 72 in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma.

Mod Pathol 1995; 8(3):260-265.

90. Grizzle WE, Myers RB, Oelschlager DK. Prognostic Biomarkers in Breast Cancer:

Factors Affecting Immunohistochemical Evaluation. Breast 1995; 1(4):243-250.

91. Parker CR, Stankovic AK, Falany DN, Grizzle WE. Effect of TGF-beta on

dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells. Ann NY

Acad Sci 1995; 774:326-328.

92. Parker CR, Stankovic AK, Falany CN, Faye-Petersen O, Grizzle WE.

Immunocytochemical Analyses of Dehydroepiandroisterone Sulfotransferase in Cultured

Human Fetal Adrenal Cells. J Clin Endocrinol Metab 1995; 80(6):1027-1031.

93. Robinson ML, Overbeek PA, Verran DJ, Grizzle WE, Stockard CR, Friesel R., Maciag

T, Thompson JA. Extracellular FGF-1 Acts as a Lens Differentiation Factor in

Transgenic Mice. Development 1995; 121(2):505-514.

94. Parker CR, Faye-Petersen O, Stankovic AK, Mason JI, Grizzle WE.

Immunohistochemical Evaluation of the Cellular Localization and Ontogeny of 3β-


Hydroxysteroid Dehydrogenase/Delta 5-4 Isomerase in the Human Fetal Adrenal Gland.

Endocr Res 1995; 21(1-2):69-80.

95. Myers RB, Lampejo O, Herrera GA, Srivastava S, Oelschlager D, Grizzle WE. TGFα

Expression is a Relatively Late Event in the Progression of Prostatic Adenocarcinoma. J

Urol Pathol 1995; 3: 195-204.

96. Bell DS, Grizzle WE, Dunlap NE. Neisidioblastosis Causing Reversal of Insulin-

Dependent Diabetes and Development of Hyperinsulinemic Hypoglycemia. Diabetes

Care 1995; 18(10):1379-1380.

97. Sekar MC, Sambandam V, Roy D, Grizzle WE. Decreased Cyclic Inositol

Phosphohydrolase Activity in Hamster Renal Tumors and Human Renal Cell

Carcinomas. Biochem Mol Med 1995; 56(2):104-107.

98. Sekar MC, Sambandam V, Grizzle WE, McDonald JM. Dissociation of cyclic inositol

phosphohydrolase activity from annexin III. J Biol Chem 1996; 271(14):8295-8299.

99. Faye-Petersen OM, Arnold MM, Grizzle WE, Lie JT. Lymphoplasmacytic Aortitis and

Acute Aortic Dissection: An Uncommon Association. Arch Pathol Lab Med 1996;

120(4):402-404.

100. Raben D, Buchsbaum DJ, Khazaeli MB, Rosenfeld ME, Gillespie GY, Grizzle WE, Liu

T, Curiel DT. Enhancement of Radiolabeled Antibody Binding and Tumor Localization

Through Adenoviral Transduction of the Human Carcinoembryonic Antigen Gene. Gene

Ther 1996; 3(7):567-580.

101. Myers RB, Grizzle WE. Biomarker Expression in Prostatic Intraepithelial Neoplasia.

Eur Urol 1996; 30(2):153-166.

102. Roye GD, Myers RB, Brown D, Poczatek R, Beenken SW, Grizzle WE. CD44

Expression in Dysplastic Epithelium and Squamous-Cell Carcinoma of the Esophagus.

Int J Cancer 1996; 69(4):254-258.

103. Myers RB, Srivastava S, Oelschlager DK, Brown D, Grizzle WE. Expression of nm23-

H1 in Prostatic Intraepithelial Neoplasia and Adenocarcinoma. Hum Pathol 1996;

27(10):1021-1024.

104. Grizzle WE, Woodruff, KH, Trainer TD. The Pathologist's Role in the Use of Human

Tissues in Research - Legal, Ethical, and Other Issues. Arch Pathol Lab Med 1996;

120(10):909-912.

105. Grizzle WE. Theory and Practice of Silver Staining in Histopathology. J Histotechnol

1996; 19(3):183-195.

106. Grizzle WE. Silver Staining Methods to Identify Cells of the Dispersed Neuroendocrine

System. J Histotechnol 1996; 19(3):225-234.

107. Myers RB, Brown D, Oelschlager DK, Waterbor JW, Marshall ME, Srivastava S,

Stockard CR, Urban DA, Grizzle WE. Elevated Serum Levels of p105erbB-2

in Patients


with Advanced Stage Prostatic Adenocarcinoma. Int J Cancer 1996; 69(5):398-402.

108. Myers RB, Oelschlager DK, Hockett RD, Rogers MD, Conway-Myers BA, Grizzle WE.

The Effects of Dihydrotestosterone on the Expression of p185erbB-2

and c-erbB-2 mRNA

in the Prostatic Cell Line LNCaP. J Steroid Biochem Mol Biol 1996; 59(5-6):441-447.

109. Arnold MM, Srivastava S, Fredenburgh J, Stockard CR, Myers RB, Grizzle WE. Effects

of Fixation and Tissue Processing on Immunohistochemical Demonstration of Specific

Antigens. Biotech Histochem 1996; 71(5):224-230.

110. Meredith RF, Khazaeli MB, Plott WE, Grizzle WE, Liu T, Schlom J, Russell CD,

Wheeler RH, LoBuglio AF. Phase II Study of Dual 131

I-Labeled Monoclonal Antibody

Therapy with Interferon in Patients with Metastatic Colorectal Cancer. Clin Cancer Res

1996; 2(11):1811-1818.

111. Meredith RF, Partridge EE, Alvarez RD, Khazaeli MB, Plott G, Russell CD, Wheeler

RH, Liu T., Grizzle WE, Schlom J, LoBuglio AF. Intraperitoneal Radioimmunotherapy

of Ovarian Cancer with Lutetium-177-CC49. J Nucl Med 1996; 37(9):1491-1496.

112. Li ZH, Aaltonen LA, Shu Q, Srivastava S, Grizzle WE, Shibata D. Effects of Mutation

and Growth Rates on Patterns of Microsatellite Instability. Am J Pathol 1996;

148(6):1757-1761

113. Manne U, Myers RB, Srivastava S, Grizzle WE. Re: Loss of Tumor Marker-

Immunostaining Intensity on Stored Paraffin Slides of Breast Cancer. J Natl Cancer Inst

1997; 89(8):585-586.

114. Grizzle WE, Myers RB, Manne U. The Use of Biomarker Expression to Characterize

Neoplastic Processes. Biotech Histochem 1997; 72(2):96-104.

115. Myers RB and Grizzle WE. Changes in Biomarker Expression in the Development of

Prostatic Adenocarcinoma. Biotech Histochem 1997; 72(2):86-95.

116. Arribas R, Capella G, Tortola S, Masramon L, Grizzle WE, Perucho M, Peinado MA.

Assessment of genomic damage in colorectal cancer by DNA fingerprinting: prognostic

applications. J Clin Oncol 1997; 15(10)3230-40.

117. Grizzle WE. Biomarkers - The New Frontier in the Pathology of Invasive and

Preinvasive Neoplasias. Biotech Histochem 1997; 72(2):59-61.

118. Manne U, Myers RB, Moron C, Poczatek RB, Dillard S, Weiss H, Brown D, Srivastava

S, Grizzle WE. Prognostic Significance of Bcl-2 Protein Expression and p53 Nuclear

Accumulation in Colorectal Adenocarcinoma. Int J Cancer 1997; 74(3):346-358.

119. Alvarez RD, Partridge EE, Khazaeli MB, Plott G, Austin M, Kilgore L, Russell CD, Liu

T, Grizzle WE, Schlom J, LoBuglio AF, Meredith RF. Intraperitoneal

Radioimmunotherapy of Ovarian Cancer with 177

Lu-CC49: A Phase I/II Study. Gynecol

Oncol 1997; 65(1):94-101.

120. Kim M, Wright M, Deshane J, Accavitti MA, Tilden A, Saleh M, Vaughan WP, Carabasi


MH, Rogers MD, Hockett RD, Grizzle WE, Curiel DT. A Novel Gene Therapy Strategy

for Elimination of Prostate Carcinoma Cells from Human Bone Marrow. Hum Gene

Ther 1997; 8(2):157-170.

121. Parker CR, Mixon RL, Brissie RM, Grizzle WE. Aging Alters Zonation in the Adrenal

Cortex of Men. J Clin Endocrinol Metab 1997; 82(11):3898-901.

122. Colin IM, Kopp P, Zbaren J, Haberli A, Grizzle WE, Jameson JL. Expression of Nitric

Oxide Synthase III in Human Thyroid Follicular Cells: Evidence for Increased

Expression in Hyperthyroidism. Eur J Endocrinol 1997; 136(6):649-655.

123. Swanson SM, Whitaker LM, Stockard CR, Myers RB, Oelschlager D, Grizzle WE,

Juliana M, Grubbs CJ. Hormone levels and mammary epithelial cell proliferation in rats

treated with a regimen of estradiol and progesterone that mimics the preventive effect of

pregnancy against mammary cancer. Anticancer Res 1997; 17(6D):4639-4645.

124. Saleh MN, Tilden AB, Meredith RF, LoBuglio AF, Grizzle WE. Chimeric Antibodies

with Specificity for Tumor Antigens: Demonstration of in situ Localization to Tumors

after Antibody Therapy. Biotech Histochem 1998; 73(4):186-197.

125. Fabian CJ, Kimler BF, Elledge RM, Grizzle WE, Beenken SW, Ward, JH. Models for

early chemoprevention trials in breast cancer. Hematol Oncol Clin North Am 1998;

12(5):993-1017.

126. Manne U, Weiss HL, Myers RB, Danner OK, Moron C, Srivastava S, Grizzle WE.

Nuclear Accumulation of p53 in Colorectal Adenocarcinoma: Prognostic Importance

Differs with Race and Location of the Tumor. Cancer 1998; 83(12):2456-2467.

127. Grizzle WE, Aamodt R, Clausen K, LiVolsi V, Pretlow TG, Qualman S. Providing

Human Tissues for Research: How to Establish A Program. Arch Pathol Lab Med 1998;

122(12):1065-1076.

128. Stackhouse MA, Buchsbaum DJ, Grizzle WE, Bright SJ, Olsen CC, Kancharla S, Mayo

MS, Curiel DT. Radiosensitization mediated by a transfected anti-erbB-2 single chain

antibody in vitro and in vivo. Int J Radiat Oncol Biol Phys 1998; 42(4):817-822.

129. Rogers BE, Garver RI, Grizzle WE, Buchsbaum DJ. Genetic Induction of Antigens and

Receptors as Targets for Cancer Radiotherapy. Tumor Targeting 1998; 3:122-137.

130. Myers RB, Oelschlager DK, Coan PN, Frost AR, Weiss HL, Manne U, Pretlow TG,

Grizzle WE. Changes in Cyclin Dependent Kinase Inhibitors p21 and p27 During the

Castration Induced Regression of the CWR22 Model of Prostatic Adenocarcinoma. J

Urol 1999; 161(3):945-949.

131. Myers RB, Oelschlager D, Manne U, Coan PN, Weiss H, Grizzle WE. Androgenic

Regulation of Growth Factor and Growth Factor Receptor Expression in the CWR22

Model of Prostatic Adenocarcinoma. Int J Cancer 1999; 82(3):424-429.

132. Grizzle WE, Grody WW, Noll WW, Sobel ME, Stass SA, Trainer T, Travers H, Weedn

V, Woodruff K. Recommended Policies for Uses of Human Tissue in Research,


Education, and Quality Control. Ad Hoc Committee on Stored Tissue, College of

American Pathologists. Arch Pathol Lab Med 1999; 123(4):296-300.

133. Krontiras H, Roye GD, Beenken SE, Myers RB, Mayo MS, Peters GE, Grizzle WE.

Fatty Acid Synthase Expression is Increased in Neoplastic Lesions of the Oral Tongue.

Head Neck 1999; 21(4):325-329.

134. Stackhouse MA, Buchsbaum DJ, Kancharla SR, Grizzle WE, Grimes C, Laffoon K,

Pederson LC, Curiel DT. Specific Membrane Receptor Gene Expression Targeted with

Radiolabeled Peptide Employing the erbB-2 and DF3 Promoter Elements in Adenoviral

Vectors. Cancer Gene Ther 1999; 6(3):209-219.

135. Beenken S, Sellers M, Huang P, Peters G, Krontiras H, Dixon P, Stockard C, Listinsky C,

Grizzle WE. Transforming Growth Factor α (TGFα), Expression in Dysplastic Oral

Leukoplakia: Modulation by 13-cis Retinoic Acid. Head Neck 1999;21(6):566-573.

136. Poczatek RB, Myers RB, Manne U, Oelschlager D, Weiss HL, Bostwick DG, Grizzle

WE. Ep-CAM Levels in Prostatic Adenocarcinoma and Prostatic Intraepithelial

Neoplasia. J Urol 1999; 162(4):1462-1466.

137. Urban D, Myers R, Manne U, Weiss H, Mohler J, Perkins D, Marklewicz M, Lieberman

R, Kelloff G, Marshall M and Grizzle W. Evaluation of Biomarker Modulation by

Fenreinide in Prostate Cancer Patients. Eur Urol 1999; 35(5-6):429-438.

138. Saleh MN, Raisch KP, Stackhouse MA, Grizzle WE, Bonner JA, Mayo MS, Kim H-G,

Meredith RF, Wheeler RH, Buchsbaum DJ. Combined Modality Therapy of A431

Human Epidermoid Cancer Using Anti-EGFr Antibody C225 and Radiation. Cancer

Biother Radiopharm 1999; 14(6); 451-463.

139. Meredith RF, Khazaeli MB, Macey DJ, Grizzle WE, Mayo M, Schlom J, Russell CD,

LoBuglio AF. Phase II Study of Interferon-Enhanced 131

I-Labeled High Affinity CC49

Monoclonal Antibody Therapy in Patients with Metastatic Prostate Cancer. Clin Cancer

Res 1999; 5(10 Suppl):3254s-3258s.

140. Foster KW, Ren S, Louro ID, Lobo-Ruppert SM, McKie-Bell P, Grizzle W, Hayes MR,

Broker TR, Chow LT, Ruppert JM. Oncogene Expression Cloning by Retroviral

Transduction of Adenovirus E1A-Immortalized Rat Kidney RK3E Cells: Transformation

of a Host with Epithelial Features by c-MYC and the Zinc Finger Protein GKLF1. Cell

Growth Differ 1999; 10(6):423-434.

2000

141. Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE. The

Expression of Ep-CAM (17-1A) in Squamous Cell Cancers of the Lung. Hum Pathol

2000; 31(4):482-487.

142. Zinn KR, Buchsbaum DJ, Chaudhuri T, Mountz JM, Grizzle WE, Rogers BE.

Noninvasive Monitoring of Gene Transfer Using a Reporter Receptor Imaged with a

High Affinity Peptide Radiolabeled with 99m

Tc or 188

Re. J Nucl Med 2000; 41(5):887-

895.


143. Piyathilake CJ, Johanning GL, Macaluso M, Whiteside, MA, Oelschlager DK,

Heimburger DC, Grizzle WE. Localized Folate and Vitamin B-12 Deficiency in

Squamous Cell Lung Cancer is Associated with Global DNA Hypomethylation. Nutr

Cancer 2000; 37(1): 99-107.

144. Piyathilake CH, Bell WC, Johanning GL, Cornwell PE, Heimburger DC, Grizzle WE.

The Accumulation of Ascorbic Acid by Squamous Cell Carcinomas of the Lung and

Larynx is associated with Global Methylation of DNA. Cancer 2000;89(1): 171-176.

145. Stackhouse MA, Pederson LC, Grizzle WE, Curiel DT, Gebert J, Haack K, Vickers SM,

Mayo MS, Buchsbaum DJ. Fractionated radiation therapy in combination with

adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances

cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models.

Gene Ther 2000; 7(12):1019-1026.

146. Weiss HL, Rodriguez-Burford C, Grubbs CJ, Grizzle WE. Longitudinal Analysis of

Mammary Cancer Multiplicity in Chemoprevention Studies. Anticancer Res 2000;

20(4):2281-7.

147. Ren S, Smith MJ, Louro ID, McKie-Bell P, Bani MR, Wagner M, Zochodne B, Redden

DT, Grizzle WE, Wang ND, Smith DI, Herbst RA, Bardenheuer W, Opalka B, Schutte J,

Trent JM, Ben-David Y, Ruppert JM. The p44S10 locus, encoding a subunit of the

proteasome regulatory particle, is amplified during progression of cutaneous malignant

melanoma. Oncogene 2000; 19(11):1419-27.

148. Adachi Y, Reynolds PN, Yamamoto M, Grizzle WE, Overturf K, Matsubara S,

Muramatsu T, Curiel DT. Midkine Promoter-based Adenoviral Vector Gene Delivery for

Pediatric Solid Tumors. Cancer Res 2000; 60(16):4305-4310.

149. Manne U, Weiss H, Grizzle WE. Racial differences in the prognostic usefulness of MUC1

and MUC2 in colorectal adenocarcinomas. Clin Cancer Res 2000; 6(10):4017-25.

150. Manne U, Weiss HL, Grizzle WE. Bcl-2 Expression is Associated with Improved

Prognosis in Patients with Distal Colorectal Adenocarcinomas. Int J Cancer 2000;

89(5):423-30.

151. Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC, Grizzle WE.

The Expression of Fatty Acid Synthease (FASE) is an Early Event in the Development

and Progression of Squamous Cell Carcinoma of the Lung. Hum Pathol 2000;

31(9):1068-73.

152. Meredith R, Alvarez R, Partridge E, Kilgore L, Khazaeli M, Grizzle W, Barnes M,

Austin JM, Scholm J, LoBuglio A. Enhanced Radioimmunotherapy (RIT) for Ovarian

Cancer: Results of a Phase I/II Trial. Gynecol Oncol 2000;76(2):258.

153. Foster KW, Frost AR, McKie-Bell P, Lin CY, Engler JA, Grizzle WE, Ruppert JM.

Increase of GKLF Messenger RNA and Protein Expression during Progression of Breast

Cancer. Cancer Res 2000; 60(22):6488-95.


154. Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE,

Heimburger DC, Niveleau A. Immunohistochemical Evaluation of Global DNA

Methylation: Comparison with In Vitro Radiolabeled Methyl Incorporation Assay.

Biotech Histochem 2000; 75(6):251-8.

155. Frost A, Sparks D, and Grizzle WE, Methods of antigen recovery vary in their

usefulness in unmasking specific antigens in immunohistochemistry. App

Immunohistochem Mol Morphol 2000; 8(3):236-43.

156. Reynolds PN, Zinn KR, Gavrilyuk VD, Balyasnikova IV, Rogers BE, Buchsbaum DJ,

Wang MH, Miletich DJ, Grizzle WE, Douglas JT, Danilov SM, Curiel DT. A

targetable, injectable adenoviral vector for selective gene delivery to pulmonary

endothelium in vivo. Mol Ther 2000; 2(6):562-578.

2001

157. Urban D, Irwin W, Kirk M, Markiewicz MA, Myers R, Smith M, Weiss H, Grizzle WE,

Barnes S. The Effect of Isolated Soy Protein on Plasma Biomarkers in Elderly Men with

Elevated Serum Prostate Specific Antigen. J Urol 2001; 165:294-300.

158. Grizzle WE, Manne U, Jhala NC, Weiss HL. Molecular Characterization of Colorectal

Neoplasia in Translational Research. Arch Pathol Lab Med 2001; 125(1):91-98.

159. Rodriguez-Burford C, Lubet RA, Steele VE, Eto I, Bandy M, Juliana MM, Weiss HL,

Grizzle WE, Kelloff GJ, Grubbs CJ. Effects of acute and chronic body weight gain

reductions in the evaluation of agents for efficacy in mammary cancer prevention. Oncol

Rep 2001; 8(2):373-9.

160. Yamamoto M, Alemany R, Adachi Y, Grizzle WE, Curiel DT. Characterization of the

Cyclooxygenase-2 Promoter in an Adenoviral Vector and Its Application for the

Mitigation of Toxicity in Suicide Gene Therapy of Gastrointestinal Cancers. Mol Ther

2001; 3(3):385-94.

161. Gibbons MD, Manne U, Carroll WR, Peters GE, Weiss HL, Grizzle WE. Molecular

Differences in Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Major

Salivary Glands. Laryngoscope 2001; 111(8):1373-8.

162. Beenken SW, Grizzle WE, Crowe DR, Conner MG, Weiss HL, Sellers MT, Krontiras H,

Urist MM, Bland KI. Molecular Biomarkers for Breast Cancer Prognosis: Co-expression

of c-erbB-2 and p53. Ann Surg 2001; 233(5):630-8.

163. Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R,

Bayesian Monitoring of a Phase 2 Chemoprevention Trial in High-risk Cohorts for

Prostate Cancer. Urology 2001; 57(4 Suppl. 1):220-3.

164. Myers RB, Oelschlager DK, Weiss HL, Frost, AR, Grizzle WE. Fatty Acid Synthase -

An Early Molecular Marker of Progression of Prostatic Adenocarcinoma to Androgen

Independence. J Urol, Investigative Urology 2001; 165(3):1027-32.

165. Eltoum I, Fredenburgh J, Myers RB, Grizzle WE. Introduction to the Theory and


Practice of Fixation of Tissues. J. Histotechnol 2001; 24(3):173-90.

166. Grizzle WE, Stockard CR, Billings PE. The Effects of Tissue Processing Variables

Other Than Fixation on Histochemical Staining and Immunohistochemical Detection of

Antigens. J Histotechnol 2001; 24(3):213-9.

167. Eltoum I, Fredenburgh J, Grizzle WE. Advanced Concepts in Fixation: Effects of

Fixation on Immunohistochemistry, Reversibility of Fixation and Recovery of Proteins,

Nucleic Acid, and other Molecules from Fixed and Processed Tissues, Developmental

Methods of Fixation. J Histotechnol 2001; 24 (3); 201-210.

168. Rodríguez-Burford C, Barnes MN, Berry W, Partridge EE, Grizzle WE.

Immunohistochemical expression of molecular markers in an avian model: a potential

model for pre-clinical evaluation of agents for ovarian cancer chemoprevention.

Gynecology/Oncology 2001; 81(3):373-9.

169. Mountz JD, Van Zant GE, Zhang HG, Grizzle WE, Ahmed R, Williams RW, Hsu HC.

Genetic dissection of age-related changes of immune function in mice. Scand J Immunol

2001; 54(1-2):10-20.

170. Piyathilake CJ, Frost AR, Bell WC, Oelschlager D, Weiss H, Johanning GL, Niveleau A,

Heimburger DC, Grizzle WE. Altered global methylation of DNA: an epigenetic

difference in susceptibility for lung cancer is associated with its progression. Hum Pathol

2001; 32(8):856-62.

171. Reynolds PN, Nicklin SA, Kaliberova L, Boatman BG, Grizzle WE, Balyasnikova IV,

Baker AH, Danilov SM, Curiel DT. Combined transductional and transcriptional

targeting improves the specificity of transgene expression in vivo. Nat Biotechnol 2001;

19 (9):838-842.

172. Grizzle WE, Fredenburgh J. Avoiding biohazards in medical, veterinary and research

laboratories. Biotech Histochem 2001; 76 (4):183-206.

173. Jones WT, Stockard CR, Grizzle WE. Effects of time and temperature during

attachment of sections to microscope slides on immunohistochemical detection of

antigens. Biotech Histochem 2001; 76 (2):55-8.

174. Meredith RF, Alvarez RD, Partridge EE, Khazaeli MB, Lin C-Y, Macey DJ, Austin JM,

Kilgore LC, Russell CD, Grizzle WE, Schlom J, LoBuglio AF. Intraperitoneal

radioimmunochemotherapy of ovarian cancer: A phase I study. Cancer Biother

Radiopharm 2001; 16 (4) 305-15.

175. Manne U, Gary BD, Oelschlager DK, Weiss HL, Frost AR , Grizzle WE. Altered

subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an

independent prognostic factor in colorectal adenocarcinomas. Clin Cancer Res 2001;7

(11): 3495-503.

176. Scott G, Deng A, Rodriguez-Burford C, Seiberg M, Han R, Babiarz L, Grizzle W, Bell W,

Pentland A. Protase-activated receptor 2, a receptor involved in melanosome transfer, is

upregulated in human skin by ultraviolet irradiation. J Invest Dermatol 2001;117(6):1412-


1420.

2002

177. Grizzle WE, Manne U, Weiss HL, Jhala N, Talley LI. Molecular staging of colorectal

cancer in African-American and Caucasian patients using phenotypic expression of p53,

Bcl-2, MUC-1 and p27kip-1

. Int J Cancer 2002;97(4):403-9.

178. Rodriguez-Burford C, Barnes MN, Oelschlager DK, Myers RB, Talley LI, Partridge EE,

Grizzle WE. Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian

carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents. Clin

Cancer Res, 2002. 8(1):202-9.

179. Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC and Grizzle

WE. Differential expression of growth factors in squamous cell carcinoma and pre-

cancerous lesions of the lung. Clin Cancer Res 2002;8:734-744.

180. Miller CR, Gustin AN, Vickers SM, Manne U, Grizzle WE, Buchsbaum DJ, Diasio RB,

Johnson, MR. Quantitation of cytosine deaminase mRNA by real-time RT-PCR: A

sensitive method for assessing 5-Flurocytosine toxicity in vitro. Analytical Biochemistry

2002;301(2):189-199.

181. Zinn KR, Chaudhuri TR, Krasnykh VN, Buschbaum DJ, Belousova N, Grizzle WE,

Curiel DT, Rogers BE. Gamma camera dual imaging with a somatostatin receptor and

thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology

2002; 223(2):417-425.

182. Beenken S, Hockett Jr R, Grizzle W, Weiss HL, Pickens A, Perloff M, Malone WF,

Bland KI. Transforming growth factor (TGF-): A surrogate endpoint biomarker? J

Am Coll Surg 2002;195(2):149-158.

183. Grizzle WE, Mountz JD, Yang PA, Xu, X, Sun, S, Van Zant GE, Williams RW, Hsu

HC, Zhang HG. BXD recombinant inbred mice represent a novel T cell-mediated

immune response tumor model. Int J Cancer 2002; 101:270-279.

184. Barnes MN, Grizzle WE, Grubbs CJ, Partridge EE. Paradigms for primary prevention of

ovarian carcinoma. CA Cancer J Clin 2002;52(4):216-225.

185. Jewell SD, Srinivasan M, McCart LM, Williams N, Grizzle WE, LiVolsi V, MacLennan

G, Sedmak DD. Analysis of the molecular quality of human tissues: An experience from

the Cooperative Human Tissue Network. Am J Clin Pathol 2002;118(5): 733-741.

186. Fabian CJ, Kimler BF, Brady DA, Mayo MS, Chang CHJ, Ferraro JA, Zalles CM,

Stanton AL, Masood S, Grizzle WE, Boyd NF, Arneson DW, Johnson KA. A phase II

breast cancer chemoprevention trial of oral DFMO: breast tissue, imaging, and serum and

urine markers. Clin Cancer Res 2002; 8(10):3105-3117.

187. Rodriguez-Burford C, Steele VE, Anderson A, Stockard CR, Weiss HL, Eto I, Johanning

GL, Grizzle WE, Grubbs CJ. Effects of body weight gain reduction resulting from

chemopreventive agent treatment on mammary gland morphology. Nutr Cancer 2002;

43(1):67-75.


188. Barnes MN, Berry WD, Straughn JM, Kirby Tom, Leath CA, Huh WK, Grizzle WE. A

pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an

avian model of spontaneous ovarian carcinogenesis. Gynecol Oncol 2002; 87(1):57-63.

189. Talley LI, Grizzle WE, Waterbor JW, Brown K, Weiss H, Frost AR. Hormone receptors

and proliferation in breast carcinomas of equivalent histologic grades in pre- and

postmenopausal women. Int J Cancer 2002; 98(1):118-127.

190. Robles LD, Frost AR, Davila M, Hutson AD, Grizzle WE, Chakrabarti R. Down-

regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. J Biol Chem 2002;

277(28):25431-8.

191. Piyathilake CJ, Bell WC, Oelschlager DK, Heimburger CD, Grizzle WE. The pattern of

expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers

of the lung, larynx, and oral cavity. Head Neck 2002; 24(9):859-867.

192. Alvarez RD, Huh WK, Khazaeli MB, Meredith RF, Partridge EE, Kilgore LC, Grizzle

WE, Shen S, Austin JM, Barnes MN, Carey D, Schlom J, LoBuglio AF. A phase I study

of combined modality (90) Yttrium-CC49 intraperitoneal radioimmunotherapy for

ovarian cancer. Clin Cancer Res 2002; 8(9):2806-11.

193. Posey JA, Khazaeli MB, Bookman MA, Nowrouzi A, Grizzle WE, Thornton J, Carey

DE, Lorenz JM, Sing AP, Siegall CB, LoBuglio AF, Saleh MN. A phase I trial of the

single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid

tumors. Clin Cancer Res 2002; 8(10):3092-9.

194. Buschbaum DJ, Bonner JA, Grizzle WE, Stackhouse MA, Capenter M, Hicklin DJ,

Bohlen P, Raisch KP. Treatment of pancreatic cancer xenografts with Erbitux (IMC-

C225) anti-EGFR antibody, gemcitabine, and radiation. Int J Radia Oncol Biol Phys

2002; 54(4): 1180-93.

195. MacLennan PA, Delzell E, Sathiakumar N, Meyers SL, Cheng H, Grizzle WE, Chen

VW, Wu XC. Cancer incidence among triazine herbicide manufacturing workers. J

Occup Environ Med 2002; 44(11):1048-58.

2003

196. Bell WC, Myers RB, Oelschlager DK, Hosein T, Grizzle WE. The response of

extracellular signal-regulated kinase (ERK) to androgen induced proliferation in the

androgen sensitive prostate cancer cell line, LNCaP. Biotechnic and Histochem 2003;

78(1):11-16.

197. Zhang HG, Grizzle WE. Aging, immunity, and tumor susceptibility. Immunol Allergy

Clin N Am 2003; 23:83-102.

198. Rodriguez-Burford, C, Oelschlager DK, Talley LI, Barnes MN, Partridge EE, Grizzle

WE. The use of dimethyl sulfoxide (DMSO) as a vehicle in cell culture experiments

using ovarian carcinoma cell lines. J Biotech & Histochem 2003; 78(1):17-21.


199. Alvarez RD, Conner MG, Weiss H, Klug PM, Niwas S, Manne U, Bacus J, Kagan V,

Sexton KC, Grubbs CJ, Eltoum IE, Grizzle WE. The efficacy of 9-cis retinoic acid

(aliretinoin) as a chemopreventive agent for cervical dysplasia: Results of a randomized

double blind clinical trial. Cancer Epidemiol Biomarkers Prev 2003; 12(2):114-9.

200. Piyathilake CJ, Frost AR, Manne U, Weiss H, Heimburger DC, Grizzle WE. Nuclear

accumulation of p53 is a potential marker for the development of squamous cell lung

cancer in smokers. Chest 2003; 123(1):181-6.

201. Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z, Cao X.

Smad4 as a transcription corepressor for estrogen receptor alpha. J Biol Chem 2003;

278(17): 15192-15200.

202. Piyathilake CJ, Henao O, Frost AR, Macaluso M, Bell WC, Johanning GL, Heimburger

DC, Niveleau A, Grizzle WE. Race- and age-dependent alterations in global

methylation of DNA in squamous cell carcinoma of the lung (United States). Cancer

Causes and Control 2003;14:37-42.

203. Luo B, Liu L, Tang L, Zhang J, Stockard CR, Grizzle WE, Fallon MB. Increased

pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1

in cirrhotic and portal hypertensive rats: a potential mechanism in experimental

hepatopulmonary syndrome. J Hepatol 2003; 38(5):556-63.

204. Poulin N, Frost A, Carraro A, Mommers E, Guillaud M, Van Diest PJ, Grizzle W,

Beenken S. Risk biomarker assessment for breast cancer progression: replication

precision of nuclear morphometry. Anal Cell Pathol 2003; 25(3):129-38.

205. Mahasreshti PJ, Kataram M, Wang MH, Stockard CR, Grizzle WE, Carey D, Siegal GP,

Haisma HJ, Alvarez RD, Curiel DT. Intravenous delivery of adenovirus-mediated

soluble FLT-1 results in liver toxicity. Clinical Cancer Res 2003; 9:2701-2710. PMID:

12855650.

206. Davila M, Frost AR, Grizzle WE, Chakrabarti R. LIM kinase 1 is essential for the

invasive growth of prostate epithelial cells: implications in prostate cancers. J Biol Chem

2003; 278(38):36868-36875.

207. Blume SW, Miller DM, Guarcello V, Shrestha K, Meng Z, Snyder RC, Grizzle WE,

Ruppert JM, Gartland GL, Stockard CR, Jones DE, Emanuel P. Inhibition of

tumorigenicity by the 5’-untranslated RNA of the human c-myc P0 transcript. Exp Cell

Res 2003; 288(1):131-42.

208. Rosenthal EL, Shreenivas S, Peters GE, Grizzle WE, Desmond R, Gladson CL.

Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell

carcinoma. Laryngoscope 2003; 113(8):1406-10.

209. Buschbaum DJ, Zhou T, Grizzle WE, Oliver PG, Hammond CJ, Carpenter M, LoBuglio

AF. Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in

combination with chemotherapy and/or radiation therapy in a human breast cancer

model. Clinical Cancer Res 2003; 9:3731-41.


210. Chhieng DC, Rodriguez-Burford C, Talley LI, Sviglin H, Stockard CR, Kleinberg MJ,

Barnes MN, Partridge EE, Khazaeli MB, Grizzle WE. Expression of CEA, Tag-72, and

Lewis-Y antigen in primary and metastatic lesions of ovarian carcinoma. Hum Pathol

2003; 34(10):1016-21.

211. Zhang J, Ling Y, Luo Bm, Tang L, Ryter SW, Stockard CR, Grizzle WE, Fallon MB.

Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in

experimental hepatopulmonary syndrome. Gastroenterology 2003; 125(5):1441-51.

212. Chhieng DC, Benson E, Eltoum I, Eloubeidi MA, Jhala N, Jhala D, Siegal GP, Grizzle

WE, Manne U. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained

by fine-needle aspiration. Cancer 2003; 99(6):365-71.

213. Rodriguez-Burford C, Chhieng DC, Stockard CR, Kleinberg MJ, Barnes MN, Partridge

EE, Weiss HL, Grizzle WE. P53 and erbB-2 are not associated in matched cases of

primary and metastatic ovarian carcinomas. Dis Markers 2003; 19(1):11-17.

214. Weiss HL, Niwas S, Grizzle WE, Piyathilake C. Receiver operating characteristic

(ROC) to determine cut-off points of biomarkers in lung cancer patients. Disease

Markers 2003; 19(6):273-8.

2004

215. Straughn JM Jr, Shaw DR, Guerrero A, Bhoola SM, Racelis A, Wang Z, Chiriva-

Internati M, Grizzle WE, Alvarez RD, Lim SH, Strong TV. Expression of sperm protein

17 (Sp17) in ovarian cancer. Int J Cancer 2004; 108(6)805-11.

216. Bonner JA, Buchsbaum DJ, Rogers BE, Grizzle WE, Trummell HQ, Curiel DT, Fiveash

JB, Ove R, Paisch KP. Adenoviral vector-mediated augmentation of epidermal growth

factor receptor (EGFR) enhances the radiosensitization properties of anti-EGFR

treatment in prostate cancer cells. Int J Radiat Oncol Biol Phys 2004; 58(3):950-8.

217. Vital-Reyes V, Tellez-Velasco T, Chhieng D, Grizzle WE, Reyes-Fuentes A.

Spontaneous pregnancy in a patient with premature ovarian failure: A Case Report. J

Reproductive Medicine; 2004; 49: 989-991.

218. Manne U, Jhala N, Jones J, Weiss HL, Chatla C, Meleth S, Suarez-Cuervo C, Grizzle

WE. Prognostic significance of p27kip-1 expression in colorectal adenocarcinomas is

associated with tumor stage. Clin Cancer Res 2004; 10(5):1743-52.

219. Li L, Hsu HC, Stockard CR, Yang P, Zhou J, Wu Q, Grizzle WE, Mountz JD. IL-12

inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation.

J Immunol 2004; 172(5):2909-16.

220. Ponnazhagan S, Mahendra G, Kumar S, Shaw DR, Stockard CR, Grizzle WE, Meleth S.

Adeno-associated virus 2-mediated anti-angiogenic cancer gene therapy: long-term

efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single

factor. Cancer Res 2004; 64(5):1781-7.

221. Qualman SJ, France M, Grizzle WE, LiVolsi VA, Moskaluk CA, Ramirez NC,


Washington MK. Establishing a tumour bank: banking, informatics and ethics. Br J

Cancer 2004; 90(6):1115-9.

222. Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng

DC, Grizzle WE, Engler JA, Krontiras H, Bland KI, LoBuglio AF, Lobo-Ruppert SM,

Ruppert JM. Nuclear localization of KLF4 is associated with an aggressive phenotype in

early-stage breast cancer. Clin Cancer Res 2004; 10(8):2709-19.

223. Ling Y, Zhang J, Luo B, Song D, Liu L, Tang L, Stockard CR, Grizzle WE, Ku DD,

Fallon MB. The role of endothelin-1 and the endothelin B receptor in the pathogenesis of

hepatopulmonary syndrome in the rat. Hepatology 2004; 39(6):1593-602.

224. Dulaimi E, De Caceres II, Uzzo RG, Al-Saleem T, Greenberg RE, Polascik TJ, Babb JS,

Grizzle WE, Cairns P. Promoter hypermethylation profile of kidney cancer. Clin

Cancer Res 2004; 10(12):3972-9.

225. Alexander D, Chatla C, Funkhouser E, Meleth S, Grizzle WE, Manne U. Post-surgical

disparity in survival between African-Americans and Caucasians with colonic

adenocarcinomas. Clin Cancer Res 2004; 101(1):66-76.

226. Chhieng DC, Frost AR, Niwas S, Weiss H, Grizzle WE, Beeken S. Intratumor

heterogeneity of biomarker expression in breast carcinomas. Biotech Histochem 2004;

79(1):25-36.

227. Grizzle WE, Adam BL, Bigbee WL, Conrads TP, Carroll C, Feng Z, Izbicka E, Jendoubi

M, Johnsey D, Kagan J, Leach RJ, McCarthy DB, Semmes OJ, Srivastava S, Thompson

IM, Thornquist MD, Verma M, Zhang Z, Zou Z. Serum protein expression profiling for

cancer detection: validation of a SELDI-based approach for prostate cancer. Disease

Markers 19(2003, 2004):185-195.

228. Grizzle WE, Meleth S. Clarification in the point/counterpoint discussion related to

Surface-Enhanced Laser Desorption/Ionization Time of Flight Mass Spectrometric

identification of patients with adenocarcinomas of the prostate: Proteomic pattern

complexity reveals a rich and unchartered continent of biomarkers. Clin Chem 2004;

50(8):1475-7.

229. Grizzle WE, Semmes OJ, Basler J, Izbicka E, Feng Z, Kagan J, Adam BL, Troyer D,

Srivastava S, Thornquist M, Zhang Z, Thompson I. The early detection research network

surface-enhanced laser desorption and ionization prostate cancer detection study: A study

in biomarkers validation in genitourinary oncology. Urol Oncol 2004; 22(4):337-43.

230. Fabian CJ, Kimler BF, Anderson J, Tawfik OW, Mayo MS, Burak WE Jr,

O’Shaughnessy JA, Albain KS, Hyams DM, Budd GT, Ganz PA, Sauter ER, Beenken

SW, Grizzle WE, Fruehauf JP, Arneson DW, Bacus JW, Lagios MD, Johnson KA,

Browne D. Breast cancer chemoprevention phase I evaluation of biomarker modulation

by Arzoxifene, a third generation selective estrogen receptor modulator. Clin Can

Research 2004; 10:5403-5417.

231. Ploeger LS, Belien JAM, Poulin NM, Grizzle W, van Diest PJ. Confocal 3D DNA

cytometry: assessment of required coefficient of variation by computer simulation. Cell


Oncol 2004; 26(3):93-9.

232. Singh S, Singh UP, Grizzle WE, Lillard JW. CXCL12-CXCR4 interactions modulate

prostate cancer cell migration, metalloproteinase expression and invasion. Laboratory

Investigation 2004; 84(12):1666-76.

233. Kaliberov SA, Kaliberova LN, Stockard CR, Grizzle WE, Buchsbaum DJ. Adenovirus-

mediated FLT1-targeted proapoptotic gene therapy of human prostate cancer. Mol Ther

2004;10(6):1059-1070.

234. Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW. Expression and functional role

of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res 2004; 10:8743-

8750.

2005

235. Mahendra G, Kumar S, Isayeva T, Mahasreshti P, Curiel DT, Stockard CR, Grizzle WE,

Alapati V, Singh R, Siegal GP, Meleth S, Ponnazhagan S. Antiangiogenic cancer gene

therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like

tyrosine kinase-1 receptor. Cancer Gene Ther 2005; 12(1):26-34.

236. Semmes OJ, Feng Z, Adam BL, Banez LL, Bigbee WL, Campos D, Cazares LH, Chan

DW, Grizzle WE, Izbicka E, Kagan J, Malik G, McLerran D, Moul JW, Partin A,

Prasanna P, Rosenzweig J, Sokoll LJ, Srivastava S, Srivastiva S, Thompson I, Welsh MJ,

White N, Winget M, Yasui Y, Zhang Z, Zhu L. Evaluation of serum protein profiling by

surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the

detection of prostate cancer: 1. Assessment of platform reproducibility. Clinical

Chemistry 2005; 51(1):102-12.

237. Bumpers HL, Huang MB, Powell M, Grizzle WE, Lillard J, Okoli J, Bond VC. Effects

of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer.

Cancer Biol Ther 2005; 4(1):65-69.

238. Mountz JD, Yang P, Wu Q, Zhou J, Tousson A, Fitzgerald A, Allen J, Wang X, Cartner

S, Grizzle W.E., Yi N, Lu L. Genetic segregation of spontaneous erosive arthritis and

generalized autoimmune disease in the BXD2 recombinant inbred strain of mice. Scand

J Immunol 2005; 61(2):128-38.

239. Malik G, Ward MD, Gupta SK, Trosset MW, Grizzle WE, Adam BL, Diaz JI, Semmes

OJ. Serum levels of an isoforms of Apolipoprotein A-II as a potential marker for prostate

cancer. Clin Cancer Res 2005; 11(3):1073-1085.

240. Everts M, Kim-Park SA, Preuss MA, Passineau MJ, Glasgow JN, Pereboev AV,

Mahasreshti PJ, Grizzle WE, Reynolds PN, Curiel DT. Selective induction of tumor-

associated antigens in murine pulmonary vasculature using double-targeted adenoviral

vectors. Gene Ther 2005; 12:1042-1048.

241. Alexander D, Jhala N, Chatla C, Steinhauer J, Funkhouser E, Coffey CS, Grizzle WE,

Manne U. High-grade tumor differentiation is an indicator of poor prognosis in African

Americans with colonic adenocarcinomas. Cancer 2005; 103(10):2163-70.


242. Aamodt RL, Anouna A, Baird P, Beck JC, Bledsoe MA, DeSouza Y, Grizzle WE, Gosh

J, Holland NT, Hakimian R, Michels C, Pitt KE, Sexton KC, Shea K, Stark A, Vaught J.

Best practices for repositories I: collection, storage and retrieval of human biological

materials for research. Cell Preservation Tech 2005; 3: 5-48.

243. Stonecypher MS, Byer SJ, Grizzle WE, Carroll SL. Activation of the Neuregulin-

1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in

human malignant peripheral nerve sheath tumors. Oncogene 2005; 24:5589-5605.

244. Li QN, Wu L, Oelschlager D, Wan M, Stockard CR, Grizzle WE, Wang N, Chen H, Sun

Y, Cao X. Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor α

positive breast cancer cells. J Biol Chem 2005; 280(29):27022-27028.

245. Yang, X, Wang J, Liu C, Grizzle WE, Yu S, Zhang S, Barnes S, Koopman WJ, Mountz

JD, Kimberly RP, Zhang HG. Cleavage of p53-vimentin complex enhances tumor

necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid

arthritis synovial fibroblasts. Am J Pathol 2005; 167(3):705-19.

246. Barnes MN, Chhieng DF, Dreher M, Jones JL, Grizzle WE, Jones L, Talley L, Partridge

EE. Feasibility of performing chemoprevention trials in women at elevated risk of

ovarian carcinoma: Initial examination of celecoxib as a chemopreventive agent.

Gynecol Oncol 2005; 98:376-382.

247. Piyathilake C, Bell W, Jones J, Henao O, Heimburger D, Nieleau A, Grizzle WE.

Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis. Head & Neck

2005; 27(12):1061-7.

248. Forero A, Meredith RF, Khazaeli MB, Shen S, Grizzle WE, Carey D, Busby E,

LoBuglio AF, Robert F. Phase I study of (90) Y-CC49 monoclonal antibody therapy in

patients with advanced non-small cell lung cancer: effect of chelating agents and

paclitaxel co-administration. Cancer Biother Radiopharm 2005; 20(5):467-78.

249. Piyathilake CJ, Bell WC, Jones J, Henao OL, Heimburger DC, Niveleau A, Grizzle WE.

Patterns of global DNA and histone methylation appear to be similar in normal

dysplastic and neoplastic oral epithelium of humans. Dis Markers 2005; 21(3):147-51.

250. Ploeger LS, Huisman A, van der Gugten J, van der Giezen DM, Belien JA, Abbaker AY,

Dullens HF, Grizzle WE, Poulin NM, Meijer GA, van Diest PJ. Implementation of

accurate and fast DNA cytometry by confocal microscopy in 3D. Cell Oncol 2005;

27(4):225-30.

251. Rodriguez-Burford C, Mercurio M, Carey D, Han R, Gordon G, Niwas S, Bell W, Elmets

CA, Grizzle WE, Pentland AP. Selective cyclooxygenase-2 inhibition produces

heterogenous erythema response to UV-irradiation. J Invest Dermatol 2005;

125(6):1317-20.

252. Huisman A, Ploeger LS, Dullens H.F, Poulin N, Grizzle WE, van Diest PJ.

Development of 3-D chromatin texture analysis using confocal laser scanning

microscopy. Cell Oncol 2005; 27(5-6):335-45.


253. Meleth S, Eltoum IA, Zhu L, Oelschlager D, Piyathilake C, Chhieng D, Grizzle WE.

Novel approaches to smoothing and comparing SELDI TOF spectra. Cancer Informatics

2005; 1(1):78-85.

254. Grizzle WE, Semmes OJ, Bigbee W, Zhu L, Malik G, Oelschlager DK, Manne B,

Manne U. The need for the review and understanding of SELDI/MALDI mass

spectrometry data prior to analysis. Cancer Informatics 2005; 1(1):86-97.

255. Luo B, Tang L, Wang Z, Zhang J, Ling Y, Feng W, Sun JZ, Stockard CR, Frost AR,

Chen YF, Grizzle WE, Fallon MB. Cholangiocyte endothelin 1 and transforming

growth factor beta 1 production in rat experimental hepatopulmonary syndrome.

Gastroenterology 2005; 129(2): 682-695.

256. Chatla C, Jhala NC, Katkoori VR, Alexander D, Meleth S, Grizzle WE, Manne U.

Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with

tumor stage of colorectal adenocarcinoma. Cancer Biomarkers 2005; 1:241-250.

2006

257. Vital-Reyes V, Chhieng D, Rodriguez-Burford C, Tellez-Velasco, Grizzle W, Chavarria-

Olarte ME, Reyes-Fuentes A. Ovarian biopsy in infertile patients with ovarian

dysfunction. Int J Gynecol Pathol 2006; 25(1):90-94.

258. Liu C, Yu S, Zinn K, Wang J, Zhang L, Jia Y, Kappes JC, Barnes S, Kimberly RP,

Grizzle WE, Zhang HG. Murine mammary carcinoma exosomes promote tumor growth

by suppression of NK cell function. J Immunol 2006; 176(3):1375-85.

259. Steg A, Wang W, Blanquicett C, Grunda JM, Eltoum IA, Wang K, Buchsbaum DJ,

Vickers SM, Russo S, Diasio RB, Frost AR, Grizzle WE, Johnson MR. Multiple gene

expression analyses in paraffin-embedded tissues by Taqman low density array:

application to Hedgehog and Wnt pathway analysis in ovarian endometrioid

adenocarcinoma. J Mol Diagn 2006; 8(1):76-83. PMCID:PMC1867577.

260. Straughn JM Jr, Oliver PG, Zhou T, Wang W, Alvarez RD, Grizzle WE, Buchsbaum DJ.

Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in

combination with chemotherapy and radiation therapy in a cervical cancer model.

Gynecol Oncol 2006; 101:46-54.

261. Vital-Reyes VS, Rodriguez-Burford C, Oelschlager DK, Grizzle WE. Cell density

influences the effect of celecoxib in two carcinoma cell lines. Biotech Histochem 2006;

81(1):51-54.

262. Zhang HG, Liu C, Su K, Yu S, Zhang L, Zhang S, Wang J, Cao X, Grizzle W, Kimberly

RP. A membrane form of TNF-α presented by exosomes delays T cell activation-

induced cell death. J Immunol 2006; 176(12):7385-93.

263. Vital-Reyes V, Rodriguez-Burford C, Chieng DC, Alvarado-Cabrero I, Reyes-Fuentes A,

Grizzle WE. Ovarian expression of markers associated with proliferation or apoptosis in

women with diminished ovarian reserve. Fertil Steril 2006; 86(1):176-85.


264. Vital-Reyes V, Rodriguez-Burford C, Chhieng D, Oelschlager D, Reyes-Fuentes A,

Barnes M, Grizzle WE. Celecoxib inhibits cellular growth, decreases Ki-67 expression

and modifies apoptosis in ovarian cancer cell lines. Arch Med Res 2006; 37(6):689-95.

265. Grunda JM, Nabors LB, Palmer CA, Chhieng DC, Steg A, Mikkelsen T, Diasio RB,

Zhang K, Allison D, Grizzle WE, Wang W, Gillespie GY, Johnson MR. Increased

expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and

survivin is associated with poor survival in glioblastoma multiforme (GBM). J

Neurooncol 2006 Dec;80(3):261-74.

266. Wang J, Li C, Liu Y, Mei W, Yu S, Liu C, Zhang L, Cao X, Kimberly RP, Grizzle W,

Zhang HG. JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to

tumor necrosis factor-α. Am J Pathol 2006; 169(3):889-902.

267. Jhala N, Jhala D, Vickers SM, Eltoum I, Batra SK, Manne U, Eloubeidi M, Jones JJ,

Grizzle WE. Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates:

A model for translational research application. Am J Clin Pathol 2006; 126(4): 572-9.

268. Baker AC, Eltoum I, Curry RO, Stockard CR, Manne U, Grizzle WE, Chhieng D.

Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix.

Arch Pathol Lab Med 2006; 130(10):1510-5.

269. Piyathilake CJ, Oelschlager DK, Meleth S, Partridge EE, Grizzle WE. Plasma protein

profiles differ between women diagnosed with cervical intraepithelial neoplasia (CIN) 1

and 3. Cancer Informatics 2006; 2:421-425. PMCID:PMC2675504.

270. Markert J, Parker J, Buchsbaum DJ, Grizzle WE, Gillespie GY, Whitley R. Oncoloytic

HSV-1 for the treatment of brain tumors. Herpes 2006; 13(3):66-71.

2007

271. Huisman A, Ploeger LS, Dullens HF, Jonges TN, Belien JA, Meijer GA, Poulin N,

Grizzle WE, van Diest PJ. Discrimination between benign and malignant prostate tissue

using chromatin texture analysis in 3-D by confocal laser scanning microscopy. Prostate

2007;67(3)248-54.

272. Qiu T, Grizzle WE, Oelschalger DK, Shen X, Cao X. Control of prostate cell growth:

BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in

Smad1. Embo J 2007;26(2):346-57. PMCID:PMC1783451.

273. Benavides MA, Oelschlager DK, Zhang HG, Stockard CR, Vital-Reyes VS, Katkoori

VR, Manne U, Wang W, Bland KI, Grizzle WE. Methionine inhibits cellular growth

dependent upon the p53 status of cells. Am J Surg 2007; 193(2):274-83.

274. Estes JM, Oliver PG, Straughn JM Jr, Zhou T, Wang W, Grizzle WE, Alvarez RD,

Stockard CR, LoBuglio AF, Buchsbaum DJ. Efficacy of anti-death receptor 5 (DR5)

antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue

slice model. Gynecol Oncol 2007; 105(2):291-8.


275. Liu C, Yu S, Kappes J, Wang J, Grizzle WE, Zinn KR, Zhang HG. Expansion of spleen

myeloid suppressor cells represses NK cell cytotoxicity in tumor bearing host. Blood

2007; 109(10):4336-42. PMCID:PMC1885503.

276. Hsu HC, Wu Y, Yang P, Wu Q, Job G, Chen J, Wang J. Accavitti-Loper MA, Grizzle

WE, Carter RH, Mountz JD. Overexpression of activation-induced cytidine deaminase

in B cells is associated with production of highly pathogenic autoantibodies. J Immunol

2007; 178(8):5357-65.

277. Meleth S, Chatla C, Katkoori VR, Anderson B, Hardin JM, Jhala NC, Barolucci A,

Grizzle WE, Manne U. Comparison of predicted probabilities of proportional hazards

regression and linear discriminant analysis methods using a colorectal cancer molecular

biomarker database. Cancer Inform 2007; 3:115-122. PMCID: PMC2675853.

278. Zhang HG, Kim H, Liu C, Yu S, Wang J, Grizzle WE, Kimberly RP, Barnes S.

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell

tumor cytotoxicity. Biochim Biophys Acta. 2007; 1773(7):1116-23.

PMCID:PMC2577190.

279. Yu, S, Liu C, Su K, Wang J, Liu Y, Zhang L, Li C, Cong Y, Kimberly R, Grizzle WE,

Falkson C, Zhang HG. Tumor exosomes inhibit differentiation of bone marrow dendritic

cells. J Immunol 2007; 178:6867-6875.

280. Piyathilake CJ, Azrad M, Jhala D, Macaluso M, Kabagambe K, Brill I, Niveleau A, Jhala

N, Grizzle WE. Mandatory fortification with folic acid in the United States is not

associated with changes in the degree or the pattern of global DNA methylation in cells

involved in cervical carcinogenesis. Cancer Biomarkers 2007; 2(6):259-66.

281. Davila M, Jhala D, Ghosh D, Grizzle WE, Chakrabarti R. Expression of LIM kinase 1 is

associated with reversible G1/S phase arrest, chromosomal instability and prostate

cancer. Mol Cancer 2007; 6:40. PMICD:PMC1913540.

282. Huffman DM, Grizzle WE, Bamman MM, Kim JS, Eltoum IA, Elgavish A, Nagy TR.

SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 2007;

67(14): 6612-8.

283. Chhieng DC, Rodriguez-Burford C, Meleth S, Grizzle WE, Ferguson SM. Assessment

of biomarker expression in predicting pathologic response to neoadjuvant chemotherapy

in patients with locally advanced breast cancer. Breast J 2007; 13(5):534-535.

284. Kojima K, Vickers SM, Adsay NV, Jhala NC, Kim HG, Schoeb TR, Grizzle WE, Klug

CA. Inactivation of Smad4 accelerates Kras (G12D)-mediated pancreatic neoplasia.

Cancer Res 2007; 67(17):8121-30.

285. Derosier LC, Buchsbaum DJ, Oliver PG, Huang ZQ, Sellers JC, Grizzle WE, Wang W,

Zhou T, Zinn KR, Long JW, Vickers SM. Combination treatment with TRA-8 anti death

receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of

pancreatic cancer. Clin Cancer Res 2007; 13(18):5535s-43s. PMCID:PMC3045836.

286. Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE, Vickers


SM, Saluja AK. Triptolide induces pancreatic cancer cell death via inhibition of heat

shock protein 70. Cancer Res 2007; 67(19):9407-16.

287. Steg A, Vickers SM, Eloubeidi M, Wang W, Eltoum IA, Grizzle WE, Saif MW,

Lobuglio AF, Frost AR, Johnson MR. Hedgehog pathway expression in heterogeneous

pancreatic adenocarcinoma: implications for the molecular analysis of clinically available

biopsies. Diagn Mol Pathol. 2007; 16(4):229-37.

288. Alexander DD, Waterbor J, Hughes T, Funkhouser E, Grizzle W, Manne U. African-

American and Caucasian disparities in colorectal cancer mortality and survival by data

source: An epidemiologic review. Cancer Biomark. 2007; 3(6):301-13.

PMCID:PMC2667694.

289. Chakrabarti R, Jones JL, Oelschlager DK, Tapia T, Tousson A, Grizzle WE.

Phosphorylated LIM Kinases Colocalize with gamma-Tubulin in Centrosomes During

Early Stages of Mitosis. Cell Cycle 2007; 6(23):2944-52.

290. Derosier LC, Vickers SM, Zinn KR, Huang Z, Wang W, Grizzle WE, Sellers J, Stockard

CR Jr, Zhou T, Oliver PG, Arnoletti P, Lobuglio AF, Buchsbaum DJ. TRA-8 anti-DR5

monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically

validated orthotopic pancreatic tumor growth. Mol Cancer Ther. 2007; 6(12):3198-207.

291. Grizzle WE, Xu X, Zhang S, Stockard CR, Liu C, Yu S, Wang J, Mountz JD, Zhang

HG. Age-related increase of tumor susceptibility is associated with myeloid-derived

suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred

BXD12 mice. Mech Ageing Dev. 2007; 128(11-12):672-80.

2008

292. Mackenzie KF, Topping EC, Bugaj-Gaweda B, Deng C, Cheung YF, Olsen AE, Stockard

CR, High Mitchell L, Baillie GS, Grizzle WE, De Vivo M, Houslay MD, Wang D,

Bolger GB. Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific

phosphodiesterase that has undergone rapid evolutionary change. Biochem J.

2008;411(2):361-9. PMCID:PMC4337886.

293. McLerran D, Grizzle WE, Feng Z, Thompson IM, Bigbee WL, Cazares LH, Chan DW,

Dahlgren J, Diaz J, Kagan J, Lin DW, Malik G, Oelschlager D, Partin A, Randolph TW,

Sokoll L, Srivastava S, Srivastava S, Thornquist M, Troyer D, Wright GL,Zhang Z, Zhu

L, Semmes OJ. SELDI-TOF MS Whole Serum Proteomic Profiling with IMAC Surface

Does Not Reliably Detect Prostate Cancer. Clin Chem. 2008; 54(1):53-60.

PMCID:PMC5332515.

294. McLerran D, Grizzle WE, Feng Z, Bigbee WL, Banez LL, Cazares LH, Chan DW, Diaz

J, Izbicka E, Kagan J, Malehorn DE, Malik G, Oelschlager D, Partin A, Randolph T,

Rosenzweig N, Srivastava S, Srivastava S, Thompson IM, Thornquist M, Troyer D,

Yasui Y, Zhang Z, Zhu L, Semmes OJ. Analytical Validation of Serum Proteomic

Profiling for Diagnosis of Prostate Cancer: Sources of Sample Bias. Clin Chem. 2008;

54(1):44-52. PMCID:PMC3354530.

295. Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle


WE, Manne U. Clinical significance of a novel single nucleotide polymorphism in the 5'

untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma. Front

Biosci. 2008, 13:1050-61. PMCID: PMC2667692.

296. Huffman DM, Moellering DR, Grizzle WE, Stockard CR, Johnson MS, Nagy TR.

Effect of exercise and calorie restriction on biomarkers of aging in mice. Am J Physiol

Regul Integr Comp Physiol. 2008; 294(5): R1618-27. PMCID:PMC4332519.

297. Kendrick JE, Straughn JM Jr, Oliver PG, Wang W, Nan L, Grizzle WE, Stockard CR,

Alvarez RD, Buchsbaum DJ. Anti-tumor activity of the TRA-8 anti-DR5 antibody in

combination with cisplatin in an ex vivo human cervical cancer model. Gynecol Oncol.

2008; 108(3):591-7. (PMCID not required; published before 4/2008).

298. Shanmugam C, Katkoori VR, Jhala NC, Grizzle WE, Siegal GP, Manne U. p53 Nuclear

Accumulation and Bcl-2 Expression in Contiguous Adenomatous Components of

Colorectal Adenocarcinomas Predict Aggressive Tumor Behavior. J Histochem

Cytochem. 2008; 56(3):305-12. PMCID: PMC2324183.

299. Alder MN, Herrin BR, Sadlonova A, Stockard CR, Grizzle WE, Gartland LA, Gartland

GL, Boydston JA, Turnbough CL Jr, Cooper MD. Antibody responses of variable

lymphocyte receptors in the lamprey. Nat Immunol. 2008; 9(3):319-27. (PMCID not

required; published prior to 4/2008).

300. Piyathilake CJ, Celedonio JE, Macaluso M, Bell WC, Azrad M, Grizzle WE. Mandatory

fortification with folic acid in the United States is associated with increased expression of

DNA methyltransferase-1 in the cervix. Nutrition. 2008; 24(1):94-9. PMCID:

PMC2215322.

301. Bell WC, Young ES, Billings PE, Grizzle WE. The efficient operation of the surgical

pathology gross room. Biotech Histochem. 2008; 83(2):71-82. Review.

PMCID:PMC2903959.

302. Pitt K, Campbell L, Skubitz A, Somiari S, Sexton K, Pugh R, Aamodt R, Baird P, Betsou

F, Cohen L, De Souza Y, Gaffney E, Geary P, Grizzle WE,Gunter E, Horsefall D,

Kessler J, Michels C, Kaercher E, Morales O, Morente M, Morrin H, Petersen G, Robb J,

Seberg O, Thomas J, Thorne H, Walters C, Riegman P. Best practices for repositories:

collection, storage, retrieval and distribution of biological materials for research, Second

Edition. Cell Preservation Technology. 2008; 6 (1):5-58. (PMCID not required; no

federal funding).

303. Aikhionbare FO, Mehrabi S, Thompson W, Yao X, Grizzle W, Partridge E. mtDNA

sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and

age difference. Diagn Pathol. 2008; 3:32. PMCID: PMC2494992.

304. Talley L, Chhieng DC, Bell WC, Grizzle WE, Frost AR. Immunohistochemical

detection of EGFR, p185 (erbB-2), Bcl-2 and p53 in breast carcinomas in pre-

menopausal and post-menopausal women. Biotech Histochem. 2008; 83(1):5-14.

(PMCID not required; published prior to 4/2008).

305. Kim H, Morgan DE, Zeng H, Grizzle WE, Warram JM, Stockard CR, Wang D, Zinn


KR. Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy

with novel apoptosis-inducing anti-DR5 antibody. Radiology. 2008; 248 (3):844-51.

PMCID: PMC2657851.

306. Qu Z, Van Ginkel S, Roy AM, Westbrook L, Nasrin M, Maxuitenko Y, Frost AR, Carey

D, Wang W, Li R, Grizzle WE, Thottassery JV, Kern FG. Vascular endothelial growth

factor reduces tamoxifen efficacy and promotes metastatic colonization and desmoplasia

in breast tumors. Cancer Res. 2008, 68(15):6232-40. PMCID:PMC4337242.

307. Kojima K, Asmellash S, Klug CA, Grizzle WE, Mobley JA, Christein JD. Applying

proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer. J

Gastrointest Surg. 2008; 12(10):1683-90. (PMCID not required; no federal funding).

308. Grizzle, WE, Sexton KC, Bell WC. Quality Assurance in Tissue Resources Supporting

Biomedical Research. Cell Preservation Technology. 2008; 6(2): 113-118.

PMCID:PMC3094015.

309. Kim H, Morgan DE, Buchsbaum DJ, Zeng H, Grizzle WE, Warram JM, Stockard CR,

McNally LR, Long JW, Sellers JC, Forero A, Zinn KR. Early therapy evaluation of

combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor

xenografts by diffusion-weighted magnetic resonance imaging. Cancer Res. 2008;

68(20):8369-76. PMCID: PMC2597015.

310. Wang D, Stockard CR, Harkins L, Lott P, Salih C, Yuan K, Buchsbaum D, Hashim A,

Zayzafoon M, Hardy RW, Hameed O, Grizzle W, Siegal GP. Immunohistochemistry in

the evaluation of neovascularization in tumor xenografts. Biotech Histochem. 2008;

83(3):179-89. PMCID: PMC2651088.

311. Wang GJ, Liu Y, Qin A, Shah SV, Deng ZB, Xiang X, Cheng Z, Liu C, Wang J, Zhang

L, Grizzle WE, Zhang HG. Thymus exosomes-like particles induce regulatory T cells. J

Immunol. 2008; 181(8):5242-8. PMCID:PMC4319673.

312. Newman JR, Bohannon IA, Zhang W, Skipper JB, Grizzle WE, Rosenthal EL.

Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.

Arch Otolaryngol Head Neck Surg. 2008; 134(11):1218-24. PMCID: PMC2676729.

313. Edgerton ME, Morrison C, LiVolsi VA, Moskaluk CAA, Qualman SJ, Washington MK,

Grizzle WE, A Standards Based Ontological Approach to Information Handling for Use

by Organizations Providing Human Tissue for Research. Cancer Informatics 2008;

6:127-136. PMCID: PMC2623300.

2009

314. Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Groen TV, Grizzle WE,

Ponnazhagan S, Fallon MB. Pulmonary Angiogenesis in Rat Model of Hepatopulmonary

Syndrome. Gastroenterology. 2009; 136(3):1070-80. PMCID: PMC2827330.

315. Xiang X, Poliakov A, Liu C, Liu Y, Deng ZB, Wang J, Cheng Z, Shah SV, Wang GJ,

Zhang L, Grizzle WE, Mobley J, Zhang HG. Induction of myeloid-derived suppressor

cells by tumor exosomes. Int J Cancer. 2009; 124(11):2621-33. PMCID: PMC2757307.


316. Hewitt R, Watson PH, Dhir R, Aamodt R, Thomas G, Mercola D, Grizzle WE, Morente

MM. Timing of consent for the research use of surgically removed tissue: is

Postoperative Consenting Acceptable? Cancer. 2009; 115(1):4-9. (PMCID not required;

commentary; no federal funding).

317. Singh S, Bond VC, Powell M, Singh UP, Bumpers HL, Grizzle WE, Lillard JW Jr.

CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer

cells and inhibit tumor growth. Mol Cancer Ther. 2009; 8(1):178-84.

PMCID:PMC3600559.

318. Tuck MK, Chan DW, Chia D, Godwin AK, Grizzle WE, Krueger KE, Rom W, Sanda

M, Sorbara L, Stass S, Wang W, Brenner DE. Standard Operating Procedures for Serum

and Plasma Collection: Early Detection Research Network Consensus Statement

Standard Operating Procedure Integration Working Group. J Proteome Res. 2009;

8(1):113-117. PMCID: PMC2655764.

319. Shanmugam C, Katkoori V, Jhala N, Grizzle W, Manne U. Immunohistochemical

expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine

pancreas. Biotech Histochem. 2009; 84(2):39-45. PMCID: PMC2667687.

320. Liu K, Bellam N, Lin HY, Wang B,. Stockard CR, Grizzle WE and Lin WC. Regulation

of p53 by TopBP1, a potential mechanism of p53 inactivation in cancer. Mol Cell Biol.

2009; 29(10):2673-93. PMCID: PMC2682038.

321. Katkoori V, Jia X, Shanmugam C, Wan W, Meleth S, Bumpers H, Grizzle W, Manne U,

Prognostic Significance of p53 Codon 72 Polymorphism Differs with Race in Colorectal

Adenocarcinoma. Clin Cancer Res 2009; 15(7)2406-16. PMCID:PMC3635077.

322. Bell WC, Sexton KC, Grizzle WE. How to efficiently obtain human tissues to support

specific biomedical research projects. Cancer Epidemiol Biomarkers Prev 2009:

18(6):1676-9. PMCID: PMC2694221.

323. Otali D, Stockard CR, Oelschlager DK, Wan W, Manne U, Watts SA, Grizzle WE.

Combined effects of formalin fixation and tissue processing on immunorecognition.

Biotech Histochem. 2009; 84(5):223-47. PMCID:PMC2903968.

324. Grizzle W. Special symposium: fixation and tissue processing models. Biotech

Histochem. 2009; 84(5):185-93. PMCID:PMC2891300.

325. Frederick PJ, Kendrick JE, Straughn JM Jr, Della Manna DL, Oliver PG, Lin HY,

Grizzle WE, Stockard CR, Alvarez RD, Zhou T, Lobuglio AF, Buchsbaum DJ. Effect of

TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo

human ovarian cancer model. Int J Gynecol Cancer. 2009; 19(5):814-819. (PMCID not

required; no federal funding).

326. Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle

WE, Lillard JW Jr. Clinical and biological significance of CXCR5 expressed by prostate

cancer specimens and cell lines. Int J Cancer 2009, 15;125(10):2288-95.

PMCID:PMC3600527.


327. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic

KR, Grizzle WE, Lillard JW Jr. Serum CXCL13 positively correlates with prostatic

disease, prostate-specific antigen and mediates prostate cancer cell invasion,integrin

clustering and cell adhesion. Cancer Lett 2009; 283 (1):29-35. PMCID:PMC3600557.

328. Deng ZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S,

Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG.

Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin

resistance. Diabetes. 2009; 58(11):2498-505. PMCID: PMC2768161.

329. Xu X, Hsu HC, Chen J, Grizzle WE, Chatham WW, Stockard CR, Wu Q, Yang PA,

Holers VM, Mountz JD. Increased expression of activation-induced cytidine deaminase

is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis. Scand J

Immunol. 2009; 70 (3): 309-16. PMCID:PMC3674772.

330. Li J, Wang Y, Yang C, Wang P, Oelschlager DK, Zheng Y, Tian DA, Grizzle WE,

Buchsbaum DJ, Wan M. Polyethylene glycosylated curcumin conjugate inhibits

pancreatic cancer cell growth through inactivation of Jab1. Mol Pharmacol. 2009; 76

(1):81-90. (PMCID not required; no federal funding).

331. Kaliberova LN, Krendelchtchikova V, Harmon DK, Stockard CR, Petersen AS, Markert

JM, Gillespie GY, Grizzle WE, Buchsbaum DJ, Kaliberov SA. CRAdRGDflt-IL24

virotherapy in combination with chemotherapy of experimental glioma. Cancer Gene

Ther. 2009; 16(10):794-805. PMCID:PMC4332514.

332. Jian B, Nagineni CN, Meleth S, Grizzle W, Bland K, Chaudry I, Raju R. Anosmin-1

involved in neuronal cell migration is hypoxia inducible and cancer regulated. Cell

Cycle. 2009; 8 (22):3770-6. (PMCID not required; no federal funding).

333. Kaliberova LN, Kusmartsev SA, Krendelchtchikova V, Stockard CR, Grizzle WE,

Buchsbaum DJ, Kaliberov SA. Experimental cancer therapy using restoration of NAD+-

linked 15-hydroxyprostaglandin dehydrogenase expression. Mol Cancer Ther. 2009;

8(11):3130-9. (PMCID not required; no federal funding).

334. Ren Y, Wu L, Frost AR, Grizzle W, Cao X, Wan M. Dual effects of TGF-beta on

ERalpha-mediated estrogenic transcriptional activity in breast cancer. Mol Cancer. 2009;

8:111. PMCID: PMC2787496.

335. Piyathilake CJ, Macaluso M, Celedonio JE, Badiga S, Bell WC, Grizzle WE.

Mandatory fortification with folic acid in the United States appears to have adverse

effects on histone methylation in women with pre-cancer but not in women free of pre-

cancer. Int J of Women’s Health 2009: 131-137. PMCID:PMC2971712.

336. Deng ZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, Shah SV, Zhang S, Zhang L,

Zhuang X, Michalek S, Grizzle WE, Zhang HG. Immature myeloid cells induced by a

high-fat diet contribute to liver inflammation. Hepatology 2009; 50(5):1412-20. PMCID:

PMC2852608.


2010

337. Xu L, Kwon YJ, Frolova N, Steg AD, Yuan K, Johnson MR, Grizzle WE, Desmond RA,

Frost AR. Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-

negative breast cancer. Breast Cancer Res Treat. 2010; 123(1):59-71.

PMCID:PMC2888711.

338. Anderson B, Hardin JM, Alexander DD, Meleth S, Grizzle WE, Manne U. Comparison

of the predictive qualities of three prognostic models of colorectal cancer. Frontiers in

Bioscience, E2, 665-9672. 2010. PMCID: PMC2675853.

339. Sharma PK, Singh R, Novakovic KR, Eaton JW, Grizzle WE, Singh S. CCR9 mediates

PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of

CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide. Int J Cancer. 2010;

127(9):2020-30. (PMCID not required; no federal funding).

340. Kim H, Folks KD, Guo L, Stockard CR, Fineberg NS, Grizzle WE, George JF,

Buchsbaum DJ, Morgan DE, Zinn KR. DCE-MRI Detects Early Vascular Response in

Breast Tumor Xenografts Following Anti-DR5 Therapy. Mol Imaging Biol. 2010;

13(1):94-103. PMCID:PMC128021.

341. Edgerton ME, Grizzle WE, Washington MK. The Deployment of a Tissue Request

Tracking System for the CHTN: A Case Study in Managing Change In Informatics for

Biobanking Operations. BMC Med Inform Decis Mak 2010; 10:32.

PMCID:PMC2893081.

342. Blume SW, Jackson NL, Frost AR, Grizzle WE, Shcherbakov OD, Choi H, Meng Z.

Northwestern profiling of potential translation-regulatory proteins in human breast

epithelial cells and malignant breast tissues: evidence for pathological activation of the

IGF1R IRES. Exp. Mol. Pathol. 2010; 88(3):341-52. PMCID: PMC2868104.

343. McNally LR, Welch DR, Beck BH, Stafford LJ, Long JW, Sellers JC, Huang ZQ, Grizzle

WE, Stockard CR, Nash KT, Buchsbaum DJ. KISS1 over-expression suppresses

metastasis of pancreatic adenocarcinoma in a xenograft mouse model. Clin Exp Metastasis

2010;27(8):591-600. PMCID:PMC2975384.

344. Johnson EL, Singh R, Singh S, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard Jr

JW. CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase

expression and invasion. World J Surg Oncolog. 2010; 8:62. PMCID:PMC2927595.

345. Wang CW, Manne U, Reddy VB, Oelschlager DK, Katkoori VR, Grizzle WE, Kapoor R.

Development of combination tapered fiber-optic biosensor dip probe for quantitative

estimation of interleukin-6 in serum samples. J Biomed Opt 2010; 15(6):067005.

PMCID:PMC3017577.

346. Kimball KJ, Preuss, MA, Barnes MN, Wang M, Siegal GP, Wan W, Kuo H, Saddek S,

Stockard CR, Grizzle WE, Harris R, Aurigemma R,David T Curiel DT, Alvarez R. A

Phase I Study of a Tropism Modified Conditionally Replicative Adenovirus for Recurrent

Gynecologic Malignancies. Clin Cancer Res 2010; 16(21):5277-87. PMCID:PMC2970766.


347. Mehrabi S, Akwe JA, Adams G Jr., Grizzle W, Yao X, Aikhionbare FO. Analysis of

mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol. 2010;5:66.

PMCID:PMC2959018.

348. Atha DH, Manne U, Grizzle WE, Wagner PD, Srivastava S, Reipa V. Standards for

Immunohistochemical Imaging: A protein reference device for biomarker quantitation. J

Histochem Cytochem 2010;58(11):1005-14. PMCID:PMC2958133.

349. Xiang X, Liu Y, Zhuang X, Zhang S, Michalek S, Taylor DD, Grizzle W, Zhang HG.

TLR2 mediated expansion of MDSCs is dependent on the source of tumor exosomes. Am

J Pathol 2010;177(4):1606-10. PMCID:PMC2947257.

350. Benavides MA, Hagen KL, Fang W, Du P, Lin S, Moyer MP, Yang W, Bland KI, Grizzle

WE, Bosland MC. Suppression by L-methionine of cell cycle progression in LNCaP and

MCF-7 cells but not benign cells. Anticancer Res 2010;30(6):1881-5.

PMCID:PMC4166481.

351. Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, Barnes S, Grizzle W, Miller D, Zhang

HG. A novel nanoparticle drug delivery system-the anti-inflammatory activity of curcumin

is enhanced when encapsulated in exosomes. Mol Ther 2010;18(9):1606-14.

PMCID:PMC2956928.

352. Shanmugam C, Jhala NC, Katkoori VR, Wan W, Meleth S, Grizzle WE, Manne U.

Prognostic value of MUC4 expression in colorectal adenocarcinomas. Cancer 2010;

116(15):3577-86. PMCID:PMC2910814.

353. Liu Y, Xiang X, Zhuang X, Zhang S, Liu C, Cheng Z, Michalek SM, Grizzle WE, Zhang

HG. Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived

suppressor cells. Am J Pathol 2010;176:2490-2499. PMCID:PMC2861113.

354. Piazza GA, Keeton AB, Tinsley HN, Whitt JD, Gary BD, Singh R, Grizzle WE, Reynolds

RC. NSAIDs: Old drugs reveal new anticancer targets. Pharmaceuticals 2010;3(5):1652-

1667.

355. Katkoori VR, Suarez-Cuervo C, Shanmugam C, Jhala NC, Callends T, Messiaen L, Posey

III J, Bumpers HL, Meleth S, Grizzle WE, Manne U. Bax expression is a candidate

prognostic and predictive marker of colorectal cancer. J Gastrointest Oncol 2010; 1:76-89.

PMCID:PMC3397579.

2011

356. Johnson-Holiday C, Singh R, Johnson E, Singh S, Stockard CR, Grizzle WE, Lillard JW

Jr. CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast

cancer cells in CCR9-dependent fashion. Int J Oncol. 2011;38(5):1279-85.

PMCID:PMC3760515.

357. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary

AM. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma.

Cancer Prev Res (Phila). 2011;4(1):137-49. PMCID:PMC3635802.


358. Sherman S, Shats O, Ketcham MA, Anderson MA, Whitcomb DC, Lynch HT, Ghiorzo P,

Rubinstein WS, Sasson AR, Grizzle WE, Haynatzki G, Feng J, Sherman A, Kinarsky L,

Brand RE. PCCR: pancreatic cancer collaborative registry. Cancer Inform 2011; 10:83-

91. PMCID:PMC3085425.

359. He QP, Wang J, Mobley JA, Richman J, Grizzle WE. Self-calibrated warping for mass

spectra alignment. Cancer Inform 2011; 10:65-82. PMCID:PMC3085421.

360. Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat

GK, Reddy ES. Histone deacetylase inhibitors, valproic acide and trichostatin-A induce

apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J

Oncol 2011; 1:111-9. PMCID:PMC3329756.

361. Kim H, Folks KD, Guo L, Sellers JC, Fineberg NS, Stockard R, Grizzle WE, Buchsbaum

DJ, Morgan DE, George JF, Zinn KR. Early therapy evaluation of combined cetuximab

and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contract-enhanced

magnetic resonance imaging. Mol Imaging 2011; 3:153-67. PMCID:PMC3957340.

362. Shah N, Zhai G, Knowles JA, Stockard CR, Grizzle WE, Fineberg N, Zhou T, Zinn KR,

Rosenthal EL, Kim H. (18)F-FDG PET/CT imaging detects therapy efficacy of anti-

EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts. Mol

Imaging Biol 2011; 14(2):237-44. PMCID:PMC3594775.

363. Xiang X, Zhuang X, Ju S, Jiang H, Mu J, Zhang L, Miller D, Grizzle W, Zhang HG. miR-

155 promotes macroscopic tumor formation yet inhibits tumor dissemination from

mammary fat pads to the lung by preventing EMT. Oncogene; 2011; 30(31):3440-53.

PMCID:PMC4139014.

364. Deng Z, Pardi R, Cheadle W, Xiang X, Zhang S, Shah SV, Grizzle W, Miller D, Mountz J,

Zhang HG. Plant homologue constitutive photomorphogenesis 9 (COP9) signalsome

subunit CSN5 regulates innate immune responses in macrophages. Blood 2011;

117(18):4796-804. (PMCID: not required, no federal funding).

365. Brand RE, Nolen BM, Zeh HJ, Allen PJ, Grizzle WE, Lokshin AE. Serum biomarker

panels for the detection of pancreatic cancer. Clin Can Res 2011; 17(4):805-16.

PMCID:PMC3075824.

366. Walsh SB, Xu J, Xu H, Kurundkar AR, Maheshwari A, Grizzle WE, Timares L, Huang

CC, Kopelovich L, Elmets CA, Athar M. Cyclosporine A mediates Pathogenesis of

Aggressive Cutaneous Squamous Cancer by Augmenting Epithelial-Mesenchymal

Transition: role of TGF(beta) signaling Pathways. Mol Carcinog 2011; 50(7):516-27.

PMCID:PMC3110643.

367. Zhang H-G, Grizzle WE. Exosomes and Cancer: A newly described pathway of immune

suppression. Clin Can Res 2011; 17(5):959-64. PMCID:PMC3155407.

368. Grizzle WE, Bell WC, Sexton KC. Issues in collecting, processing and storing human

tissues and associated information to support biomedical research. Cancer Biomark

2011;9(1):531-49. PMCID:PMC3445033.


369. Manne U, Shanmugam C, Katkoori VR, Bumpers HL, Grizzle WE. Development and

progression of colorectal neoplasia. Cancer Biomark 2011;9(1-6):235-65.

PMCID:PMC3445039.

370. Srivastava S., Grizzle WE. Biomarkers and the genetics of early neoplastic lesions.

Cancer Biomark 2011;(9)(1-6):41-64. PMCID:PMC3478673.

371. Grizzle WE, Srivastava S, Manne U. The biology of incipient, pre-invasive or

intraepithelial neoplasia. Cancer Biomark 2011;9(1-6):21-39. PMCID:PMC3430522.

372. Grizzle WE, Srivastava S, Manne U. Translational pathology of neoplasia. Cancer

Biomark 2011;9(1-6):7-20. PMCID:PMC3445029.

373. Grizzle WE, Srivastava S, Manne U. Editorial: Translational pathology of early cancer.

Cancer Biomark 2011;9(1-6):1-4. PMCID: PMC3445029.

374. Srivastava SK, Bhardwaj A, Singh S, Arora S, Wang B, Grizzle WE, Singh AP.

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of

pancreatic cancer cells. Carcinogenesis 2011; 12:1832-9. PMCID:PMC3220613.

375. Zhuang X, Xiang X, Axtell R, Ju S, Mu J, Sun D, Zhang L, Grizzle W, Miller D.,

Steinman L, Zhang HG. Treatment of brain inflammatory diseases by delivering exosome

encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther

2011;10:1769-79. PMCID:PMC3188748.

376. Kim H, Zhai G, Liu Z, Samuel S, Shah N, Helman EE, Knowles JA, Stockard CR,

Fineberg NS, Grizzle WE, Zhou T, Zinn KR, Rosenthal EL. Extracellular matrix

metalloproteinase as a novel target for pancreatic cancer therapy. Anticancer Drugs

2011;22(9):864-74. PMCID:PMC3587034.

377. Singh R, Stockard CR, Grizzle WE, Lillard Jr, Singh S. Expression and histopathological

correlation of CCR9 and CCL25 in ovarian cancer. Int J Oncol 2011;39(2):373-81.

PMCID:PMC3760589.

378. Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey Jr JA, Bumpers HL,

Grizzle WE, Eltoum IE, Siegal GP, Manne U. Evaluation of lymph node numbers for

adequate staging of stage II and III colon cancer. J Hemat Oncol 2011;4:25.

PMCID:PMC3124418.

379. Qin Y, Xu J, Aysola K, Begum N, Reddy V, Yuli C, Grizzle W, Partridge E, Reddy ESP,

Rao V. Ubc9 mediates nuclear localization and tumor suppression of BRCA1 and

BRCA1a proteins. J Cellular Physiology 2011;226:3355-67. PMCID:PMC3329759.

380. Hsu H-C, Yang P, Wu Q, Wang J, Job G, Guentert T, Li J, Stockard CR, Le TV, Chaplin

DD, Grizzle WE, Mountz JD. Inhibition of the catalytic function of Activation-Induced

Cytidine Deaminase promotes apoptosis of gereminal center B cells in BXD2 mice.

Arthritis & Rheumatism 2011; 63:2038-48. PMCID:PMC3379710.


381. Hensel JA, Chanda D, Kumar S, Sawant A, Grizzle WE, Siegal GP, Ponnazhagan S. LL-

37 as a therapeutic target for late stage prostate cancer. Cancer Prev Res 2011; 4(1):137-

49. PMCID:PMC3025071.

382. Benavides MA, Hu D, Baraoidan MK, Bruno A, Du P, Lin S, Yang W, Bland KI, Grizzle

WE, Bosland MC. L-methionine-induced alterations in molecular signatures in MCF-7

and LNCaP cancer cells. J Cancer Res Clin Oncol 2011; 137(3):441-53.

PMCID:PMC2988108.

383. Grizzle WE, Knoppers BM, Zeps N, Sullivan K. What are the most oppressing legal and

ethical issues facing biorepositories and what are some strategies to address them?

Biopreservation and Biobanking 2011; 9(4):317-19. PMCID:PMC4275773.

2012

384. Deng Z, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W,

Mobley J, Roman J, Miller D, Zhang HG. Tumor cell cross talk with tumor-associated

leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor

progression. Am J Pathol 2012; 180(1):390-398. (PMCID: not required, no federal

funding).

385. Meredith R, You Z, Alvarez R, Partridge E, Grizzle W, Lobuglio A. Predictors of long-

term outcome from intraperitoneal radioimmunotherapy for ovarian cancer. Cancer

Biother Radiopharm 2012; 27(1):36-40. PMCID:PMC3277922.

386. Wang H, Jones J, Turner T, He QP, Hardy S, Grizzle WE, Welch DR, Yates C. Clinical

and biological significance of KISS1 expression in prostate cancer. Am J Pathol 2012;

180 (3):1170-8. PMCID:PMC3349884.

387. Zhang H-G, X Zhuang, Sun D, Liu Y, Xiang X, Grizzle WE. Exosomes and immune

surveillance of neoplastic lesions: a review. Biotech Histochem 2012; 87(3):161-8.

PMCID:PMC3445025.

388. Bovell L, Shanmugam C, Katkoori VR, Zhang B, Vogtmann E, Grizzle WE, Manne U.

miRNAs are stable in colorectal cancer archival tissue blocks. Front Biosci (Elite Ed).

2012; 4:1937-40. PMCID:PMC3681606.

389. Bledsoe MJ, Grizzle WE, Clark BJ, Zeps N. Practical implementation issues and

challenges for biobanks in the return of individual research results. Genet Med 2012;

14(4):478-83. PMCID:PMC3388905.

390. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H,

Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle

WE, Wang H, Sen S. Aurora Kinase-A inactivates DNA damage induced apoptosis and

spindle assembly checkpoint response functions of p73. Cancer Cell 2012; 21(2):196-211.

PMCID:PMC3760020.

391. Grunda JM, Steg AD, He Q, Steciuk MR, Byan-Parker S, Johnson MR, Grizzle WE.

Differential expression of breast cancer-associated genes between stage- and age-matched


tumor specimens from African- and Caucasian-American women diagnosed with breast

cancer. BMC Res Notes 2012;5(1):248. PMCID:PMC3476447.

392. Whitt JD, Li N, Tinsley HN, Chen Xi, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi

AH, Grizzle WE, Piazza GA. A novel sulindac derivative that potently suppresses colon

tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional

activity. Cancer Prev Res 2012;5(6):822-33. PMCID:PMC3546530.

393. Anderson MA, Zolotarevsky E, Cooper KL, Sherman S, Shats O, Whitcomb DC, Lynch

HT, Ghiorzo P, Rubinstein WS, Vogel KJ, Sasson AR, Grizzle WE, Ketcham MA, Lee

SY, Normolle D, Plonka C, Mertens A, Tripon RC, Brand RE. Alchol and tobacco lower

the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a

multicenter study. Am J Gastroenterol 2012; 107(11):1730-9. PMCID:PMC3923585.

394. Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA. New NSAID

targets and derivatives for colorectal cancer chemoprevention. Recent Results Cancer Res

2012; 191:105-20. PMCID:PMC3703626.

395. Sloane PA, Shastry S, Wilhelm A, Courville C, Tang LP, Mehta N, Backer K, Levin E,

Raju SV, Li Y, Mazur M, Byan-Parker S, Grizzle W, Sorscher EJ, Dransfield MT, Rowe

SM. A pharmacologic approach to acquired cystic fibrosis transmembrane conductance

regulator dysfunction in smoking related lung disease. PLoS One 2012; 7(6):e39809.

PMCID:PMC3387224.

396. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M,

Grizzle WE, Aldred MA, Cook CD, Tuder RM. Modern age pathology of pulmonary

arterial hypertension. Am J Respir Crit Care Med 2012; 186(3):261-72.

PMCID:PMC3886716.

397. Qin Y, Xu J, Aysola K, Oprea G, Reddy A, Matthews R, Okoli J, Cantor A, Grizzle WE,

Partridge EE, Reddy ES, Landen C, Rao VN. BRCA1 proteins regulate growth of ovarian

cancer cells by tethering Ubc9. Am J Cancer Res 2012; 2(5):540-548.

PMCID:PMC3433105.

398. Srivastava SK, Bhardwaj A, Singh S, Arora S, McClellan S, Grizzle WE, Reed E, Singh

AP. Myb overexpression overrides androgen depletion-induced cell cycle arrest and

apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in

castration resistance. Carcinogenesis 2012; 33(6)1149-57. PMCID:PMC3514863.

399. Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE,

Owen LB, Singh S. CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic

cancer cells via ERK- and Akt- mediated activation of NF-kB: implications for

bidirectional tumor-stromal interactions. J Biological Chem 2012; 287(46):39115-24.

PMCID:PMC3493952.

400. Jones J, Wang H, Zhou J, Hardy S, Turner T, Austin D, He Q, Wells A, Grizzle WE, Yates

C. Nuclear kaiso indicates aggressive prostate cancers and promotes migration and

invasiveness of prostate cancer cells. Am J Pathol 2012; 181(5):1836-46.

PMCID:PMC3483816.


401. Kojima K, Bowersock GJ, Kojima C, Klug CA, Grizzle WE, Mobley JA. Validation of a

robust proteomic analysis carried out on FFPE tissues of the pancreas obtained from mouse

and human. Proteomics 2012; 12(22):3393-402. PMCID:PMC3656494.

402. Campbell, L.D., Betsou, F., Garcia, D.L.,[ …]Grizzle, W.E.[….]Sexton, K.S.[…], et al.

2012 Best practices for repositories: Collection, storage, retrieval and distribution of

biological materials for research. 3rd

edition. Biopreserv Biobank 2012;10(2):79-161.

http://doi.org/10.1089/bio.2012.1022

2013

403. Bledsoe MJ, Clayton EW, McGuire AL, Grizzle WE, O’Rourke PO, Zeps N. Return of

research results from genomic biobanks: cost matters. Genet Med 2013; 15(2):103-5.

PMCID:PMC3635086.

404. Sun D, Zhuang X, Zhang S, Deng ZB, Grizzle W, Miller D, Zhang HG. Exosomes are

endogenous nanoparticles that can deliver biological information between cells. Adv Drug

Deliv Rev 2013; 65(3):342-7. (PMCID not required; no federal funding).

405. Katkoori VR, Manne K, Vital-Reyes VS, Rodriguez C, Shanmugam C, Sthanam M, Manne

U, Chatla C, Abdulkadir SA, Grizzle WE. Selective COX-2 inhibitor (celecoxib)

decreases cellular growth in prostate cancer cell lines independent of p53. Biotech

Histochem 2013; 88(1):38-46. (PMCID not required; no federal funding).

406. Otali D, He Q, Stockard CR, Grizzle WE. Preservation of immunorecognition by

transferring cells from 10% neutral buffered formalin to 70% ethanol. Biotech Histochem

2013; 88(3-4):170-80. PMCID:PMC3737737.

407. Sharifov, OF, Xu X, Gaggar A, Grizzle WE, Mishra VK, Honavar J, Litovsky SH,

Palgunachari MN, White CR, Anantharamaiah GM, Gupta H. Anti-inflammatory

mechanisms of apoloipoproteine A-1 mimetic peotide in acute respiratory distress

syndrome secondary to sepsis. PLOS ONE 2013; 8(5):e64486. PMCID:PMC3653907.

408. Bovell LC, Shanmugam C, Putcha BDK, Zhang B, Bae S, Grizzle WE, Manne U. The

prognostic value of microRNAs varies with patient race/ethnicity and stage of colorectal

cancer. Clinical Cancer Research 2013; 19(14):3955-65. PMCID:PMC3746330.

409. Liu L, Chu KK, Houser GH, Diephuis BJ, Li Y, Wilsterman EJ, Shastry S, Dierksen GA,

Birket SE, Mazur M, Byan-Parker S, Grizzle WE, Sorscher EJ, Rowe SM, Tearney GJ.

Method for quantitative study of airway functional microanatomy using Micro-Optical

Coherence Tomography. PLOS ONE 2013;8(1):e54473. PMCID:PMC3553101.

410. Gurpinar E, Grizzle WE, Shacka JJ, Mader B, Li N, Piazza NA, Russo S, Keeton AB,

Piazza GA. A novel sulindac derivative inhibits lung adenocarcinoma cell growth through

suppression of Akt/mTOR signaling and induction of autophagy. Molecular Cancer Ther

2013;12(5):663-74. PMCID:PMC3651802.

411. Frederick PJ, Green HN, Huang JS, Egger ME, Frieboes HB, Grizzle WE, McNally LR.

Chemoresistance in ovarian cancer linked to expression of microRNAs. Biotech

Histochem 2013; 88(7):403-9. (PMCID: not required, no federal funding).

https://urldefense.proofpoint.com/v2/url?u=http-3A__doi.org_10.1089_bio.2012.1022&d=DwMFaQ&c=o3PTkfaYAd6-No7SurnLtwPssd47t-De9Do23lQNz7U&r=rbUStQj6wmXGGcCU4NOCG5QgU7iEyF9_g8SRfnlB4GE&m=7HVWNKnMXgBuKAP24_KAl2lFeajzExckSSUY5vm3_Xc&s=6bKoCbB64YElRH59OaHhg4hX8EGaa1RF3txWJ-sue80&e=


412. Kerr EH, Frederick PJ, Egger ME, Stockard CR, Sellers J, DellaManna D, Oelschlager D,

Amm HM, Eltoum IE, Straughn JM, Buchsbaum DJ, Grizzle WE, McNally LR. Lung

resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic

marker for advanced ovarian serous carcinoma. Ann Surg Oncol 2013; 20(9):3059-65.

(PMCID not required; no federal funding).

413. Srivastava SK, Bhardwaj A, Leavesley SJ, Grizzle WE, Singh S, Singh AP. MicroRNAs

as potential clinical biomarkers: emerging approaches for their detection. Biotech

Histochem 2013; 88(7):373-87. PMCID:PMC4318494.

414. McNally LR, Manne U, Grizzle WE. Post-transcriptional processing of genetic

information and its relation to cancer. Biotech Histochem 2013; 88(7):365-72.

PMCID:PMC4091847.

415. Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP, Brossier NM, Grizzle WE,

Mikhail FM, Roth KA, Carroll SL. Transgenic mice overexpressing neuregulin-1 model

neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific

chromosomal copy number variations in tumorigenesis. Am J Path 2013; 182(3):646-67.

PMCID:PMC3586689.

416. Gurpinar E, Grizzle WE, Piazza GA. COX-independent mechanisms of cancer

chemoprevention by anti-inflammatory drugs. Front Oncol 2013; 3:181.

PMCID:PMC3708159.

417. Grizzle WE. Guest Editorial: It is primarily the control of transcription and post-

transcriptional processing that are critical to the development and progression of sporadic

neoplasias. Biotech Histochem 2013; 88(7):361-4. (No PMCID required; editoral, not peer

reviewed).

418. Jones J, Grizzle W, Wang H, Yates C. MicroRNAs that affect prostate cancer: emphasis

on prostate cancer in African Americans. Biotech Histochem 2013; 88(7):410-24.

PMCID:PMC4119086.

419. Bledsoe MJ, Grizzle WE. Use of human specimens in research: the evolving US

regulatory, policy, and scientific landscape. Diagnostic Path 2013; 19(9):322-330.

PMCID:PMC3954467.

420. Bledsoe MJ, Clayton EW, McGuire AL, Grizzle WE, O’Rourke PP, Zeps N. Return of

research results from genomic biobanks: a call for data. Genet Med 2013;15(2):159-60.

(PMCID not required; not peer reviewed).

421. Sun D, Zhuang X, Zhang S, Deng ZB, Grizzle W, Miller D, Zhang HG. Exosomes are

endogenous nanoparticles that can deliver biological information between calls. Adv Drug

Deliv Rev 2013; 65(3):342-7. (PMCID not reqired; no federal funding).

422. Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA. New NSAID

targets and derivatives for colorectal cancer chemoprevention. Recent Results in Cancer

Res 2013; 191:105-20. PMCID:PMC3703626.


423. Huang JS, Egger ME, Grizzle WE, McNally LR. MicroRNA-100 regulates IGF1-receptor

expression in metastatic pancreatic cancer cells. Biotech Histochem 2013; 88(7):397-402.

PMCID:PMC4170730.

424. Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C,

Feng W, Grizzle W, Yan J, Miller D, Dronenberg M, Zhang HG. Exosome-like

nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation

of liver NKT cells. J Immunol 2013; 90(7):3579-89. (PMCID not required; no federal

funding.

425. Nolen BM, Orlichenko LS, Marrangoni A, Velikokhatnaya L, Prosser D, Grizzle WE, Ho

K, Jenkins FJ, Bovbjerg DH, Lokshin AE. An extensive targeted proteomic analysis of

disease-related protein biomarkers in urine from healthy donors. PLoS One 2013;

8(5):e63368. PMCID:PMC3665773.

426. Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA,

Grizzle WE, Owen LB, Singh AP. An undesired effect of chemotherapy: gemcitabine

promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent,

nuclear factor kB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4. J

Biol Chem 2013; 288(29):21197-207. PMCID:PMC3774385.

427. Adams G Jr, Mehrabi S, Vatcharapijarn Y, Iyamu OI, Akwe JA, Grizzle WE, Yao X,

Aikhionbare FO. Frequencies of mtDNA mutations in primary tissues of colorectal

adenopolyps. Front Biosci 2013; 5:809-13. PMCID:PMC3739296.

428. Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi

AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Sulinac selectively

inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-

catenin signaling. Mol Cancer Ther 2013; 12(9):1848-59. PMCID:PMC3800150.

429. Pan Z, Grizzle W, Hameed O. Significant variation of immunohistochemical marker

expression in paired primary and metastatic clear cell renal cell carcinomas. Am J Clin

Pathol. 2013; 140(3):410-8. (PMCID not required; no federal funding).

430. Kaliberov SA, Kaliberova LN, Hong Lu Z, Preuss MA, Barnes JA, Stockard CR, Grizzle

WE, Arbeit JM, Curiel DT. Retargeting of gene expression using endothelium specific

hexon modified adenoviral vector. Virology 2013; 447(1-2):312-25.

PMCID:PMC3894856.

431. Nguyen TL, Grizzle WE, Zhang K, Hameed O, Siegal GP, Wei S. Syndecan-1

overexpression is associated with nonluminal subtypes and poor prognosis in advanced

breast cancer. Am J Clin Pathol 2013; 140(4):468-74. (PMCID not required; no federal

funding).

432. Otali D, He Q, Grizzle WE. The effect of antigen retrieval on cells fixed in 10% neutral

buffered formalin followed by transfer to 70% ethanol. PLOS One 2013; 8(12): e82405.

PMCID:PMC3866107.


433. Grizzle WE, Moore HM. Mouse model findings and the future of human tissue in disease

research. Biopreserv Biobank 2013;11(3):135-36. (PMCID not required; no federal

funding).

2014

434. Devine DJ, Rostas JW, Metge BJ, Das S, Mulekar MS, Tucker JA, Grizzle WE,

Buchsbaum KJ, Shevde LA, Samant RS. Loss of N-Myc interactor promotes epithelial-

mesenchymal transition by activiation of TGF-β/SMAD signaling. Oncogene 2014;

33(20):2620-8. PMCID:PMC4267223.

435. Gurpinar E, Grizzle WE, Piazza GA. NSAIDs inhibit tumorigenesis, but how? Clin Cancer

Res 2014; 20(5):1104-13. PMCID:PMC3947450.

436. Benavides MA, Bosland MC, da Silva CP, Gomes Sares CT, Cerqueira de Oliveria AM,

Kemp R, Dos Reis RB, Martins VR, Sampaio SV, Bland KI, Grizzle WE, Dos Santos JS.

L-Methionine inhibits growth of human pancreatic cancer cells. Anticancer Drugs 2014;

25(2):200-3. PMCID:PMC4346324.

437. Zhang HG, Grizzle WE. Exosomes: a novel pathway of local and distant intercellular

communication that facilitates the growth and metastasis of neoplastic lesions. Am J Pathol

2014; 184(1):28-41. PMCID:PMC3873490.

438. Jones J, Wang H, Karanam B, Theodore S, Dean-Colomb W, Welch DR, Grizzle W, Yates

C. Nuclear localization of Kaiso promotes the poorly differentiataed phenotype and EMT

in infiltrating ductal carcinomas. Clin Exp Metastasis 2014;31(5):497-510.

PMCID:PMC4065802.

439. Varley KT, Gertz J, Roberts BS, Davis NS, Bowling KM, Kirby MK, Nesmith AS, Oliver

PG, Grizzle WE, Forero A, Buchsbaum DJ, LoBuglio AF, Myers RM. Recurrent read-

through fusion transcripts in breast cancer. Breast Cancer Res Treat 2014; 146(2):287-97.

PMCID:PMC4085473.

440. Londono-Joshi AI, Arend RC, Aristizabal L, Lu W, Samant RS, Metge BJ, Hidalgo B,

Grizzle WE, Conner M, Forero-Torres A, Lobuglio AF, Li Y, Buchsbaum DJ. Effect of

niclosamide on basal-like breast cancers. Mol Cancer Ther 2014; 13(4):800-11.

PMCID:PMC3981919.

441. Theodore SC, Davis M, Zhou F, Wang H, Chen D, Rhim J, Dean-Colomb W, Turner T, Ji

W, Zeng G, Grizzle W, Yates C. MicroRNA profiling of novel African American and

Caucasian prostate cancer cell lines reveals a reciprocal regulatory relationship of miR-152

and DNA methyltranferase-1. Oncotarget 2014; 5(11):3512-25. PMCID:PMC4116499.

442. Watson PH, Nussbeck SY, Carter C, O’Donoghue S, Cheah S, Matzke LAM, Barnes RO,

Bartlett J, Carpenter J, Grizzle WE, Johnston RN, Mes-Masson AM, Murphy L, Sexton K,

Shepard L, Simeon-Dubach D, Zeps N, Schater B. A framework for biobank sustainability.

Biopreservation and Biobanking 2014; 12(1):60-8. PMCID:PMC4150367.

443. Parker CR Jr, Grizzle WE, Blevins JK, Hawkes K. Development of adrenal cortical

zonation and expression of key elements of adrenal androgen production in the chimpanzee


(Pan troglodytes) from birth to adulthood. Mol Cell Endocrinol 2014; 387(1-2):35-43.

PMCID:PMC4016767.

444. Chanda D, Lee JH, Sawant A, Hensel JA, Isayeva T, Reilly SD, Siegal GP, Smith C,

Grizzle W, Singh R, Ponnazhagan S. Anterior gradient protein-2 is a regulator of cellular

adhension in prostate cancer. PLoS One 2014;9(2):e89940. PMCID:PMC3937391.

445. Bhardwaj A, Singh S, Srivastava SK, Arora S, Hyde SJ, Andrews J, Grizzle WE, Singh

AP. Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and

suppresses prostate tumor growth and metastasis in an orthotopic mouse model. Br J

Cancer 2014; 110(8):2000-10. PMCID:PMC3992501.

446. Li N, Lee K, Zhu B, Gary BD, Ramirez-Alcantara V, Gurpinar E, Canzoneri JC, Fajardo A,

Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP,

Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA. Phosphodiesterase

10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-

dependent TCF transcriptional activity. Oncogene 2015; 19;34(12):1499-509 doi:

10.1038/onc.2014.94. Epub 2014 Apr 7 PMCID:PMC4212019

447. Nolen BM, Brand RE, Prosser D, Velikokhatnaya L, Allen PJ, Zeh HJ, Grizzle WE,

Lomakin A, Lokshin AE. Prediagnostic serum biomarkers as early detection tools for

pancreatic cancer in a large prospective cohort study. PLoS One 2014; 9(4):e94928. doi:

10.1371/journal.pone.0094928. PMCID:PMC3991628.

448. Auer H, Mobley J, Ayers L, Bowen J, Chuaqui R, Johnson L, Livolsi V, Lubenski I,

McGarvey D, Monovich L, Moskaluk C, Rumpel C, Sexton K, Washington M, Wiles K,

Grizzle W, Ramirez N. The effects of frozen tissue storage conditions on the integrity of

RNA and protein. Biotech Histochem 2014;89(7):518-528. PMCID:PMC4213858.

449. Liu L, Shastry S, Byan-Parker S, Houser G, Chu K, Birket SE, Fernandez CM, Gardecki

JA, Grizzle W, Wilsterman EJ, Sorscher EJ, Rowe SM, Tearney GJ. An autoregulatory

mechnnism governing mucociliary transport is sensitive to mucus load. Am J Respir Cell

Mol Biol 2014; 51(4):485-93. PMCID:PMC4189485.

450. Meredith RF, Raische KP, Bonner JA, Buchsbaum DJ, Grizzle WE, Li Y, Spencer SA.

Pazopanib combined with radiation: in vivo model of interaction. Cancer Biother

Radiopharm 2014; 29(6):247-50. (PMCID not required; no federal funding).

451. Li H, Hsu HC, Wu Q, Yang P, Li J, Oukka M, Steele CH, Cua DJ, Grizzle WE, Mountz

JD. IL-23 promotes TCR-mediated negative selection of thymocytes through the

upregulation of IL-23 receptor and RORγt. Nature Comm 2014; 8(5):4259.

PMCID:PMC4136447.

452. Karamanian Va, Harhay M, Grant GR, Palevsky HI, Grizzle WE, Zamanian RT, Ihida-

Stansbury K, Kawut SM, Taichman DB, Jones PL. Erythropoietin upregulation in

pulmonary arterial hypertension. Pulm Circ 2014;4(2):269-79. PMCID:PMC4070770.

453. Birket SE, Chu KK, Liu L, Houser GH, Diephuis BJ, Wilsterman EJ, Dierksen G, Mazur

M, Shastry S, Li Y, Watson JD, Smith AT, Schuster BS, Hanes J, Grizzle WE, Sorscher


EJ, Tearney GJ, Rowe SM. A functional anatomic defect of the cystic fibrosis airway. Am

J Respir Crit Care Med 2014;190(4):421-32. PMCID:PMC4214131.

454. Green HN, Crockett SD, Martyshkin DV, Singh KP, Grizzle WE, Rosenthal EL, Mirov B.

A histological evaluation and in vivo assessment of intratumoral near infrared

photothermal nanotherapy-induced tumor regression. Int J Nanomedicine 2014; 9:5093-

102. PMCID:PMC4227627.

455. Desai A, Aysola K, Qin Y, Okoli C, Hariprasad R, Chinemerem U, Gates C, Reddy A,

Danner O, Franklin G, Ngozi A, Cantuaria G, Singh K, Grizzle W, Landen C, Partridge

EE, Rice VM, Reddy ES, Rao VN. Epithelial ovarian cancer: an overview. World J Transl

Med 2014; 3(1):1-8. PMCID:PMC4267287.

2015

456. Isayeva T, Xu J, Ragin C, Dai Q, Coooper T, Carroll W, Dayan D, Vered M, Wenig B,

Rosenthal E, Grizzle W, Anderson J, Willey CD, Yang ES, Brandwein-Gensler M. The

protective effect of p16(Ink4A) in oral cavity carcinomas: p16(Ink4A) dampens tumor

invasion: integrated analysis of expression and kinomics pathways. Mod Path 2015;

28(5):631-53. PMCID:PMC4607481

457. Che P, Yang Y, Han X, Hu M, Sellers JC, Londono-Joshi LJ, Cai GQ, Buchsbaum DJ,

Christein JD, Tang Q, Chen D, Li Q, Grizzle WE, Lu YY, Ding Q. S100A4 promotes

pancreatic cancer progression through a dual signaling pathway mediated by Src and focal

adhesion kinase. Sci Rep 2015; 5:8453. PMCID:PMC4326725.

458. Forero-Torres A, Varley KT, Abramson VG, Li Y, Vaklavas C, Lin NU, Liu MC, Rugo

HS, Nanda R, Storniolo AM, Traina TA, Patil S, Hayes DF, Van Poznak CH, Nangia JR,

Irvin Jr WJ, Krontiras H, De Los Santos JF, Haluska P, Grizzle W, Meyers RM, Wolff

AC. TBCRC 019: phase II trial of nab-PAC with/without the anti-death receptor 5

monoclonal antibody tigatuzumab in patients with triple negative breast cancer. Clin Can

Res 2015; 21(12):2722-9. PMCID:PMC6186432.

459. Stanley J, Klepczyk L, Keene K, Wei S, Li Y, Forero A, Grizzle W, Wielgos M, Brazelton

J, LoBuglio AF, Yang ES. PARP1 and phosphor-p65 protein expression is increased in

human HER2-positive breast cancers. Breast Cancer Res Treat 2015; 150(3):569-79.

PMCID:PMC4396624

460. Grizzle WE, Gunter EW, Sexton KC, Bell WC. Quality management of biorepositories.

Biopreservation & Biobanking 2015; 13(3):183-194. PMCID:PMC26035008

461. Putcha BD, Jia X, Katkoori VR, Salih C, Shanmugam C, Jadhav T, Bovell LC, Behring

MP, Callens T, Messiaen L, Bae S, Grizzle WE, Singh KP, Manne U. Clinical

implications of rabphillin-3A-like gene alterations in breast cancer. PLoS One. 2015 Jun

12;10(6):e0129216. PMCID:PMC4466565.

462. Vaklavas C, Meng Z, Choi H, Grizzle WE, Zinn KR, Blume SW. Small molecule

inhibitors of IRES-mediated translation. Cancer Biol Ther 2015;16(10);1471-1485 doi:

10.1080/15384047.201.1071729. PMCID:PMC4846101.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186432/


463. Anderson KC, Willey CD, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat

W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. High

throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase

acivity dependent molecular subtypes. PLoS One 2015 Sep 25;10(9): e0139267 doi:

10.1371/journal.pone.0139267. PMCID:PMC4583516.

464. Kimbrough CW, Khanal A, Zeiderman M, Khanal BR, Burton NC, McMasters KM,

Vickers S, Grizzle WE, McNally LR. Targeting acidity in pancreatic adenocarcinoma:

multispectral optoacoustic tomography detects pH-low insertion peptide probes in vivo.

Clin Can Res 2015;21(20):4576-85. PMCID:PMC4609270.

465. Yin W, Kimbrough Cw, Gomez-Gutierrez JG, Burns CT, Chuong P, Grizzle WE, McNally

LR. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo

using optoacoustic tomography. J Nanobiotechnol 2015;13(1):90. PMCID:PMC4665906.

2016

466. Boone J, Arend RC, Johnston BE, Cooper SJ, Gilchrest SA, Oelschlager DK, Grizzle

WE, McGwin G, Gangrade A, Straughn JM Jr, Buchsbaum DJ. Targeting the Wnt/β-catenin

pathway in primary ovarian cancer with the porcupine inhibitor WNT974. Laboratory

Investigation 2016;96(2):249-259. PMID:26658453

467. Li R, Zhang K, Penedo TL, Kragel CP, Grizzle WE, Hameed O, Siegal GP, Wei S. The

RANK pathway in advanced breast cancer: Does Src play a role? Applied

Immunohistochem Mol Morphol 2016;24(1):42-50. PMID: 26200837

468. Demark-Wahnefried W, Nix JW, Hunter GR, Rais-Bahrami S, Desmond RA, Chacko B,

Morrowo CD, Azrad M, Frugé AD, Tsuruta Y, Ptacek T, Tully SA,, Segal R, Grizzle WE.

Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of

caloric restriction and increased physical activity versus a wait-list control on tumor

chraacteristics and circulating biomarkers in men electing prostatectomy for prostate

cancer. BMC Cancer 2016;16:61. PMCID:PMC4743419

469. Kim H, Samuel S, Lopez-Casas PP, Grizzle WE, Hidalgo M, Kovar JL, Oelschlager D,

Zinn KR, Warram JM, Buchsbaum DJ. SPARC independent delivery of nab-paclitaxel

without depleting tumor stroma in patient-derived pancreatic cancer xenografts. Molecular

Cancer Therapeutics February 1, 2016. doi: 10.11158/1535-7163. MCT-15-0764

PMCID:PMC4873363

470. Forero A, Li Y, Chen D, Grizzle WE, Updike KL, Merz ND, Downs-Kelly E, Burwell TC,

Vaklavas C, Buchsbaum DJ, Myers RM, LoBuglio AF, Varley KE. Expression of the

MHC class II pathway in triple-negative breast cancer tumor cells is associated with a good

prognosis and infiltrating lymphocytes. Cancer Immunol Res 2016 May;4(5):390-9.

PMCID:PMC4878913

471. Birket S, Chu K, Houser G, Liu L, Fernandez C, Solomon G, Lin V, Shastry S, Mazur M,

Sloane P, Hanes J, Grizzle W, Sorscher E, Tearney G, Rowe S. Combination therapy with

cystic fibrosis transmembrane conductance regulator modulators augment the airway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873363/


functional microanatomy. Am J Physiol Lung Cell Mol Physiol 2016;310(10):L928-39. doi:

10.1152/ajplung.00395.2015. PMCID:PMC4896103

472. Ludwig MR, Kojima K, Bowersock GJ, Chen D, Steele C, Jhala NC, Christein JD,

Buchsbaum DJ, Grizzle WE, Klug CA, Mobley JA. Surveying the serologic proteome in a

tissue-specific kras(G12D) knockin mouse model of pancreatic cancer. Proteomics 2016;

16(3):516-531. PMID: 26572242

473. Betsou F, Bulla A, Cho, S-Y, Clements J, Chuaqui R, Copola D, De Souza Y, De Wilde A,

Grizzle W, Guadgni F, Gunter E, Heil S, Hodgkinson V, Kessler J, Kiehntopf M, Kim H-

S, Koppandi I, Shea K, Singh R, Sobel M, Somiari S, Spyropoulos D, Stone M, Tybring G,

Valyi-Nagy K, Van den Eynden G, Wadhwa L. Assays for qualification and quality

stratification of clinical biospecimens used in research: a technical report from the ISBER

biospecimen science working group. Biopreservation and Biobanking 2016;14(5):298-309.

PMID:27046294. PMCID:PMC5896556

474. Schultz MJ, Holdbrooks At, Chakraborty A, Grizzle WE, Landen Jr, CN, Buchsbaum DJ,

Conner MG, Arend RC, Yoon K, Klug CA, Bullard DC, Kesterson RA, Oliver PG,

O’Connor AK, Yoder BK, Bellis SL. The tumor-associated glycosyltransferase ST6Gal-I

regulates stem cell transcription factors and confers a cancer stem cell phenotype. Cancer

Res. 2016;76(13):3978-88 PMCID: PMC4930726

475. Otali D, Fredenburgh J, Oelschlager DK, Grizzle WE. A standard tissue as a control for

histochemical and immunohistochemical staining. Biotech Histochem 2016;91(5):309-26.

PMCID: PMC5338041

476. Gaignaux A, Ashton G, Coppola D, De Souza Y, De Wilde A, Eliason J, Grizzle W,

Guadagni F, Gunter E, Koppandi I, Shea K, Shi T, Stein JA, Sobel ME, Tybring G, Van

den Eynden G, Betsou F, and for the ISBER Proficiency Testing Advisory Group. A

biospecimen proficiency testing program for biobank accreditation: Four years of

experience. Biopreservation and Biobanking 2016; 14(5):429-439. PMID: 27195612

477. McNally LR, Mezera M, Morgan D, Frederick PJ, Yang ES, Eltoum I-E, Grizzle WE.

Current and emerging clinical applications of multispectral optoacoustic tomography

(MSOT) in oncology. Clinical Cancer Research 2016;22(14):3432-9.PMCID:

PMC5046137

478. Gordetsky J, Gibson B, Stevens T, Ellenburg J, Grizzle W, Rais-Bahrami S. Occult

metastases in pelvic lymphadenectomy specimens from patients with urothelial carcinoma

of the bladder. Urology 2016;94:161-166. PMID:27184604

479. Zhang J, Riby JE, Conde L, Grizzle WE, Cui X, Skibola CF. A Fucus vesiculosus extract

inhibits estrogen receptor activation and induces cell death in female cancer cell lines.

BMC Complement Altern Med. 2016;16:151. PMCID: PMC4884380

480. Kirby MK, Ramaker RC, Gertz J, Davis NS, Johnston BE, Oliver PG, Sexton KC, Greeno

EW, Christein JD, Heslin MJ, Posey JA, Grizzle WE, Vickers SM, Buchsbaum DJ,

Cooper SJ, Myers R. RNA sequencing of pancreatic adenocarcinoma tumors yields novel


http://www.ncbi.nlm.nih.gov/pubmed?term=The+tumor-associated+glycosyltransferase+ST6Gal-I+regulates+stem+cell+transcription+facors+and+confers+a+cancer+stem+ell+phenotype&db=PubMed&holding=uablib_fft&otool=uablib&myncbishare=uablib&submit=Go

http://www.ncbi.nlm.nih.gov/pubmed?term=The+tumor-associated+glycosyltransferase+ST6Gal-I+regulates+stem+cell+transcription+facors+and+confers+a+cancer+stem+ell+phenotype&db=PubMed&holding=uablib_fft&otool=uablib&myncbishare=uablib&submit=Go

http://www.ncbi.nlm.nih.gov/pubmed?term=Occult+metastases+in+pelvic+lymphadenectomy+specimens+from+patients+with+urothelial+carcinoma+of+the+bladder&db=PubMed&holding=uablib_fft&otool=uablib&myncbishare=uablib&submit=Go


expression patterns associated with long-term survival and reveals a role for ANGPTL4.

Mol Oncol 2016;10(8);1169-82. PMCID: PMC5423196

481. Zeiderman MR, Morgan DE, Christein JD, Grizzle WE, McMasters, KM, McNally LR.

Acidic pH-targeted chitosan-capped mesoporous silica coated gold nanorods facilitate

detection of pancreatic tumors via multispectral optoacoustic tomography. ACS Biomater

Sci Eng, 2016;2:1108-1120. PMCID: PMC5470628.

482. Vaklavas C, Grizzle W, Choi H, Meng Z, Zinn K, Shrestha K, Blume SW. IRES inhibition

induces terminal differentiation and synchronized death in triple-negative breast cancer and

glioblastoma cells. Tumour Biol 2016;37(10):13247-13264. PMCID: PMC5097113

483. Ottman R, Levy J, Grizzle WE, Chakrabarti R. The other face of miR-17-92a cluster,

exhibiting tumor suppressor effects in prostate cancer. Oncotarget 2016;7(45):73739-73753

PMCID: PMC5340125

484. Seijo E, Lima D, Iriabho E, Almeida J, Monico J, Echverri M, Gutierrez S, Flores I, Lee J-

H, Fisher K, Grizzle WE, Sica GL, Butler C, Hicks C, Meade CD, Sodeke SO, Moroz K,

Coppola D, Munoz-Antonia T. Construction and validation of a multi-institutional tissue

microarray of invasive ductal carcinoma from racially and ethnically diverse populations.

Cancer Control 2016;23(4):383-389. PMCID: PMC5268085

485. Grizzle WE, Otali D, Sexton KC, Atherton DS. Effects of Cold Ischemia on Gene

Expression: A Review and Commentary. Biopreserv Biobank. 2016;14(6):548-558.

PMCID:PMC5180081

486. Tsuruta Y, Rogers LQ, Krontiras H, Grizzle WE, Frugé AD, Oster RA, Umphrey HR,

Jones LW, Azrad M, Demark-Wahnefried W. Exploring effects of presurgical weight loss

among women with stage 0–II breast cancer: protocol for a randomised controlled

feasibility trial. BMJ Open 2016;6(9), p. 3012320 PMCID: PMC5030610

2017

487. Vaklavas C, Blume SW, Grizzle WE. Translational dysregulation in cancer: Molecular

insights and potential clinical applications in biomarker development. Frontiers in

Oncology. 2017;7:158. PMID: 28798901 PMCID: PMC5526920.

488. Van Neste L, Groskopf J, Grizzle WE, Adams, GW, DeGuenther MS, Kolettis PN, Bryant

JE, Kearney GP, Kearney P, Van Crieking W, Gaston S. Epigenetic risk score improves

prostate cancer risk assessment. The Prostate. 2017;77(12):1259-1264 PMID: 28762545

489. Demark-Wahefried W, Rais-Bahrami S, Desmond RA, Gordetsky JB, Hunter GR, Azrad

M, Frugé AD, Nix JW, Sudarshan S, Tsuruta Y, Tully SA, Segal R, Chacko B, Grizzle

WE. Presurgical weight loss affects tumour traits and circulating biomarkers in men with

prostate cancer. Br J Cancer, 2017;117(9):1303-1313. PMCID: PMC5672928.

490. McDaniel JM, Varley KT, Gertz J, Savic DS, Roberts BS, Bailey SK, Shevde LA,

Ramaker RC, Lasseigne BN, Kirby MK, Newberry KM, Patridge EC, Jones AL, Boone B,

Levy SE, Oliver PG, Sexton KC, Grizzle WE, Forero A, Buchsbaum DJ, Cooper SJ,




Myers RM. Genomic regulation of invasion by STAT3 in triple negative breast cancer.

Oncotarget 2017;8(5):8226-8238. PMID: 28030809 PMCID: PMC5352396

491. Bhutiani N, Grizzle WE, Galandiuk S, Otali D, Dryden GW, Egilmez NK, McNally LR.

Non-invasive Imaging of Colitis using Multispectral Optoacoustic Tomography. J Nucl

Med. 2017;58(6):1009-1012 PMID: 27908970 PMCID: PMC5450363

492. Zhu B, Lindsey A, Li N, Lee K, Ramírez-Alcántara V, Canzoneri J, Fajardo A, da Silva,

LM, Thomas M, Piazza J, Yet L, Eberhardt B, Gurpinar E, Otali D, Grizzle W,

Valiyaveettil J, Chen X, Keeton A, Piazza G. Phosphodiesterase 10A is overexpressed in

lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and

MAPK signaling. Oncotarget. 2017;8(41):69264-69280. PMCID: PMC15642477.

493. Tripathi S, Davis MB, Hughley R, He Q, Bae S, Grizzle WE, Karanam B, Marini R,

Colomb WD, Yates C. Quadruple Negative Breast Cancers in African American women

have an enriched Basal and Immune signature. J Immunol May 1, 2017, 198 (1

Supplement) 76-5. PMCID:PMC6005569.

2018

494. Bledsoe MJ, Russell-Einhorn MK, Grizzle WE. Shifting sands: the complexities and

uncertainties of the evolving US regulatory, policy, and scientific landscape for

biospecimen research, Diagnostic Histopathology. 2018;24(4):136-148.

495. Betsou F, Bilbao R, Case J, Chuaqui R, Clementws JA, De Souza Y, De Wilde Q, Geiger J,

Grizzle W, Guadagni F, Gunter E, Heil S, Kienhtopf M, Koppandi I, Lehmann S, Linsen

L, Mackenzie-Dodds J, Quesada RA, Tebbakha R, Selander T, Shea K, Sobel M, Somairi

S, Spyropoulos D, Stone M, Tybring G. Valyi-Nagy K, Wadhwa L, ISBER Biospecimen

Science Working Group. Standard PREanalytical Code version 3.0. Biopreservation and

Biobanking 2018;16(1):9-12.

496. Abisoye-Ogunniyan A, Lin H, Ghebremedhin A, Salam A, Karanam B, Theodore S, Jones-

Trich J, Davis M, Grizzle W, Wang H, Yates C. Transcriptional Repressor Kaiso Promotes

Epithelial to Mesenchymal Transition and Metastasis in Prostate Cancer through Direct

Regulation of miR-200c. Cancer Lett. 2018;431:1-10 PMCID:PMC6158022

497. Campbell LD, Astrin JJ, DeSouza Y, Giri, J, Patel AA, Rawley-Payne M, Rush A and

Sieffert N. The 2018 Revision of the ISBER Best Practices: Summary of Changes and the

Editorial Team's Development Process. Biopreservation and Biobanking 2018;16(1): 3-6.

498. Gaffney EF, Riegman PH, Grizzle WE, Watson PH. Factors that drive the increasing use

of FFPE tissue in basic and translational cancer research. Biotech Histochem.

2018;93(5):373-386.

499. Vaklavas C, Zinn K, Samuel S, Meng Z, Grizzle W, Choio H, Blume S. Translational

control of the undifferentiated phenotype in ER-positive breast tumor cells: cytoplasmic

localization of ER-alpha and impact of IRES inhibition. Oncology Reports

2018;39(6):2482-2498 PMID: 29620220. PMCID:PMC5983923.

500. Samykutty A, Grizzle WE, Fouts BL, McNally MW, Chong P, Thomas A, Chiba A, Otali

D, Woloszynska A, Said N, Frederick PJ, Jasinski J,, Liu J, McNally LR. Optoacoustic

https://urldefense.proofpoint.com/v2/url?u=https-3A__www.ncbi.nlm.nih.gov_pubmed_29751044&d=DwMFAg&c=o3PTkfaYAd6-No7SurnLtwPssd47t-De9Do23lQNz7U&r=X9M9ED7tqBKtM7PpD_oqmw&m=IHFRHT4B8U9HBLBox-c-gbielMOfsm0Jq7HtHGH1cdU&s=g11f9w5QrLtjJ1bNYDf4cOXgB0DHBcwB7170uRm-dIc&e=




imaging identifies ovarian cancer in vivo using a microenvironment targeted theranostic

wormhole mesoporous silica nanoparticle. Biomaterials. 2018;182:114-126 PMID:

30118979 PMCID: PMC6289590.

501. Chakravarthi BVSK, Del Carmen M, Pena, R, Agarwal S, Chandrashekar DS,

Balasubramanya SAH, Jabboure FJ, Matoso A, Bivalacqua TJ, Rezeaei K, Chaux A,

Grizzle WE, Sonpavde G, Gordetsky J, Netto GJ, Varambally S. A role for de novo purine

metabolic enzyme PAICS in bladder cancer progression. Neoplasia 2018;20(9):894-904

PMID: 30121007 PMCID: PMC6098199.

502. Grizzle WE, Sexton KC. Commentary on improving biospecimen utilization by classic

biobanks: Identifying past and minimizing future mistakes. In Special Issue: Biospecimen

Utilization: A Critical Challenge in Global Bioresource/Biobanking Operations, editors

William E. Grizzle and Marianna J. Bledsoe, Biopreserv Biobank. 2019;17:243-247

PMID: 30508389 PMCID: PMC6588113

503. Grizzle WE, Sexton KC, McGarvey D, Menchhofen ZV, LiVolsi V. Lessons learned

during three decades of operations of two prospective bioresources in Special Issue:

Biospecimen Utilization: A Critical Challenge in Global Bioresource/Biobanking

Operations, editors William E. Grizzle and Marianna J. Bledsoe, Biopreserv Biobank.

2018;16(6):483-492 PMID: 30457879. PMCID:PMC6308275

504. Gaston SM, Grizzle WE, Rais-Bahrami S, Kearney GP. Nitrocellulose tissue prints: An

innovative approach to preparing high quality DNA and RNA from prostate biopsies

without compromising the cores for pathology diagnosis. Transl Androl Urol 2018

Sep;7(Suppl 4):S514-S-518. PMID:30363516. PMCID:PMC6178309.

505. Bailey MH, Tokheim C, Porta-Pardo E et al.: Comprehensive Characterization of Cancer

Driver Genes and Mutations. Cell. 2018;173:371-385 e318. PMID: 29625053.

PMCID:PMC6029450

506. Berger AC, Korkut A, Kanchi RS et al.: A Comprehensive Pan-Cancer Molecular Study of

Gynecologic and Breast Cancers. Cancer Cell. 2018;33:690-705 e699. PMID: 29622464.

PMCID:PMC5959730

507. Campbell JD, Yau C, Bowlby R et al.: Genomic, Pathway Network, and Immunologic

Features Distinguishing Squamous Carcinomas. Cell Rep. 2018;23:194-212 e196. PMID:

29617660. PMCID:PMC6002769

508. Chen H, Li C, Peng X, Zhou Z et al.: A Pan-Cancer Analysis of Enhancer Expression in

Nearly 9000 Patient Samples. Cell. 2018.;173:386-399 e312. PMID: 29625054.

PMCID:PMC5890960

509. Chiu HS, Somvanshi S, Patel E et al.: Pan-Cancer Analysis of lncRNA Regulation

Supports Their Targeting of Cancer Genes in Each Tumor Context. Cell Rep.

2018;23:297-312 e212. PMID: 29617668. PMCID:PMC5906131

510. Ding L, Bailey MH, Porta-Pardo E et al.: Perspective on Oncogenic Processes at the End of

the Beginning of Cancer Genomics. Cell. 2018;173:305-320 e310. PMID: 29625049.

PMCID:PMC5916814

https://www.ncbi.nlm.nih.gov/pubmed/30118979



511. Ellrott K, Bailey MH, Saksena G et al.: Scalable Open Science Approach for Mutation

Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell Syst. 2018;6:271-281

e277. PMID: 29596782. PMC

512. Gao Q, Liang WW, Foltz SM et al.: Driver Fusions and Their Implications in the

Development and Treatment of Human Cancers. Cell Rep. 2018;23:227-238 e223. PMID:

29617662. PMCID:PMC5916809

513. Ge Z, Leighton JS, Wang Y et al.: Integrated Genomic Analysis of the Ubiquitin Pathway

across Cancer Types. Cell Rep. 2018;23:213-226 e213. PMID: 29617661.

PMCID:PMC5916807

514. Hoadley KA, Yau C, Hinoue T et al.: Cell-of-Origin Patterns Dominate the Molecular

Classification of 10,000 Tumors from 33 Types of Cancer. Cell. 2018;173:291-304 e296.

PMID: 29625048. PMCID:PMC5957518

515. Huang KL, Mashl RJ, Wu Y et al.: Pathogenic Germline Variants in 10,389 Adult Cancers.

Cell. 2018;173:355-370 e314. PMID: 29625052. PMCID:PMC5949147

516. Jayasinghe RG, Cao S, Gao Q et al.: Systematic Analysis of Splice-Site-Creating

Mutations in Cancer. Cell Rep. 2018;23:270-281 e273. PMID: 29617666. PMC

517. Knijnenburg TA, Wang L, Zimmermann MT et al.: Genomic and Molecular Landscape of

DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell Rep. 2018;

23:239-254 e236. PMID: 29617664. PMCID:PMC5961503

518. Liu J, Lichtenberg T, Hoadley KA et al.: An Integrated TCGA Pan-Cancer Clinical Data

Resource to Drive High-Quality Survival Outcome Analytics. Cell. 2018;173:400-416

e411. PMID: 29625055. PMC

519. Liu Y, Sethi NS, Hinoue T et al.: Comparative Molecular Analysis of Gastrointestinal

Adenocarcinomas. Cancer Cell. 2018;33:721-735 e728. PMID: 29622466.

PMCID:PMC5966039

520. Malta TM, Sokolov A, Gentles AJ et al.: Machine Learning Identifies Stemness Features

Associated with Oncogenic Dedifferentiation. Cell. 2018;173:338-354 e315. PMID:

29625051. PMCID:PMC5902191

521. Peng X, Chen Z, Farshidfar F et al.: Molecular Characterization and Clinical Relevance of

Metabolic Expression Subtypes in Human Cancers. Cell Rep. 2018;23:255-269 e254.

PMID: 29617665. PMCID:PMC5916795

522. Ricketts CJ, De Cubas AA, Fan H et al.: The Cancer Genome Atlas Comprehensive

Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2018;23:3698. PMID:

29925010. PMC

523. Sanchez-Vega F, Mina M, Armenia J et al.: Oncogenic Signaling Pathways in The Cancer

Genome Atlas. Cell. 2018;173:321-337 e310. PMID: 29625050. PMCID:PMC6070353

524. Saltz J, Gupta R, Hou L et al.: Spatial Organization and Molecular Correlation of Tumor-

Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell Rep.

2018;23:181-193 e187. PMID: 29617659. PMCID:PMC5943714


525. Schaub FX, Dhankani V, Berger AC et al.: Pan-cancer Alterations of the MYC Oncogene

and Its Proximal Network across the Cancer Genome Atlas. Cell Syst. 2018;6:282-300

e282. PMID: 29596783. PMCID:PMC5892207

526. Seiler M, Peng S, Agrawal AA et al.: Somatic Mutational Landscape of Splicing Factor

Genes and Their Functional Consequences across 33 Cancer Types. Cell Rep.

2018;23:282-296 e284. PMID: 29617667. PMCID:PMC5933844

527. Taylor AM, Shih J, Ha G et al.: Genomic and Functional Approaches to Understanding

Cancer Aneuploidy. Cancer Cell. 2018;33:676-689 e673. PMID: 29622463.

PMCID:PMC6028190

528. Thorsson V, Gibbs DL, Brown SD et al.: The Immune Landscape of Cancer. Immunity.

2018;48:812-830 e814. PMID: 29628290. PMCID:PMC5982584

529. Wang Z, Yang B, Zhang M et al.: lncRNA Epigenetic Landscape Analysis Identifies

EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle

Progression in Cancer. Cancer Cell. 2018;33:706-720 e709. PMID: 29622465. PMCID:

PMC6143179

530. Way GP, Sanchez-Vega F, La K et al.: Machine Learning Detects Pan-cancer Ras Pathway

Activation in The Cancer Genome Atlas. Cell Rep. 2018;23:172-180 e173. PMID:

29617658. PMCID:PMC5918694

531. Davis M, Tripathi S, Hughley R, He Q, Bae S, Karanam B, Martini R, Newman L, Colomb

W, Grizzle W, Yates C. AR negative triple negative or “quadruple negative” breast

cancers in African American women have an enriched basal and immune signature. PLOS

One 13(6): e0196909. June 18, 2018. https://doi.org/10.1371/journal.pone.0196909.

PMCID:PMC6005569.

532. Bledsoe MJ, Grizzle WE. Biospecimen Utilization: A Critical Challenge in Global

Bioresource/Biobanking Operations. In Special Issue: Biospecimen Utilization: A Critical

Challenge in Global Bioresource/Biobanking Operations, editors William E. Grizzle and

Marianna J. Bledsoe, Biopreserv Biobank 2019;17(3):21-203.

533. Grizzle WE, Sexton KC. Commentary on improving biospecimen utilization by classic

biobanks: Identifying past and minimizing future mistakes. In Special Issue: Biospecimen


William E. Grizzle and Marianna J. Bledsoe, Biopreserv Biobank. 2019;17:243-247

PMID: 30508389 PMCID: PMC6588113.

534. Watson PH, Hewitt RE, Catchpoole, DR, Grizzle WE. Biobank: What's in a Name? in

Special Issue: Biospecimen Utilization: A Critical Challenge in Global

Bioresource/Biobanking Operations, editors William E. Grizzle and Marianna J. Bledsoe,

Biopreserv Biobank. 2019;17(3):24-208.

535. Otali D, Al Diffalha S, Grizzle WE. Biological, Medical, and other Tissue Variables

Affecting Biospecimen Utilization in Special Issue: Biospecimen Utilization: A Critical

Challenge in Global Bioresource/Biobanking Operations, editors William E. Grizzle and

Marianna J. Bledsoe, Biopreserv Biobank. 2019;17(3):258-263.

https://doi.org/10.1371/journal.pone.0196909

https://uab-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_maryannliebert_s10_1089_bio_2019_29053_mjb&context=PC&vid=Lister_Hill&lang=en_US&search_scope=EVERYTHING&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,grizzle%20william%20e.&sortby=date&mode=Basic&offset=10


536. Grizzle WE, Bledsoe MJ, Al Diffalha S, Otali D, Sexton KC. The utilization of

biospecimens: Impact of the choice of biobanking model in Special Issue: Biospecimen


William E. Grizzle and Marianna J. Bledsoe, Biopreserv Biobank June 2019;17:230-242

537. Al Diffalha S, Sexton KC, Watson PH, Grizzle WE. The importance of human tissue

bioresources in advancing biomedical research in Special Issue: Biospecimen Utilization:

A Critical Challenge in Global Bioresource/Biobanking Operations, editors William E.

Grizzle and Marianna J. Bledsoe, Biopreserv Biobank, June 2019;17:209-212.

538. Demark-Wahnefried W, Rogers L, Gibson J, Harada S, Fruge A, Oster R, Grizzle W,

Norian L, Yang E, Della Manna D, Jones L, Azrad M, Krontiras H. Randomized trial of

weight loss in primary breast cancer: impact on body composition, circulating biomarkers

and tumor characteristics. Int J Cancer 2019 Aug 23, doi: 10.1002/ijc.32637. (Epub ahead

of print).

Manuscripts in Press

1. Grizzle WE, Kittles R, Rais-Bahrami S, Shah E, Adams G, DeGuenther M, Kolettis P,

Nix J, Bryant J, Chinsky R, Kearns J, Dehimer K, Terrin N, Chang H, Gaston S. Self-

identified African Americans and prostate cancer risk: West African genetic ancestry is

associated with prostate cancer diagnosis and with higher Gleason sum on biopsy. (In

Press, Cancer Medicine).

2. Behring M, Hale K, Ozaydin B, Grizzle WE, Sodeke SO, Manne U. Inclusiveness and

Ethical Considerations for Observational, Translational, and Clinical Cancer Health

Disparity Research. (In press, Cancer).

3. Grizzle WE. Commentary: Issues in the use of human tissues to support precision

medicine. (In press, Journal of Health Care for the Poor and Underserved).

4.

Manuscripts Submitted

1. Vaklavas C, Blume SW, Grizzle WE. Hallmarks and determinants of oncogenic

translation revealed by ribosome profiling in models of breast cancer. (Submitted)

2. Chandrashekar DS, Chakravarthi BVSK, Robinson A, Anderson J, Agarwal S,

Balasubramanya SAH, Eich M-L, Bajpai A, Davuluri S, Guru M, Guru A, Naik G, Della

Manna D, Acharya D, Carskadon S, Manne U, Crossman D, Ferguson J, Grizzle W,

Palanisamy N, Willey C, Crowley M, Netto G, Yang E, Sonpavde G, and Varambally S.

Therapeutically actionable PAK4 is amplified, overexpressed and is involved in bladder

cancer progression. (Submitted)

Other Publications (letters to the editor, book reviews, editorials, etc.)

1. Grizzle WE. Membranous nephropathy in a renal allograft. Arch Pathol Lab Med

(Letter to Editor) 1981;105:560


2. Grizzle WE, Mowry RW. FDA regulation of immunochemicals used in

immunohistochemistry: Our view. Biotech Histochem (Letter to Editor)

1994;69(6):348-350

3. Fredenburgh J and Grizzle WE. FIXATION: Impact of Histopathology from

Hematoxylin and Eosin Stains to Immunostaining (Part I). American Society of Clinical

Pathologists Teleconference - Continuing Education, 1996.

4. Fredenburgh J and Grizzle WE. FIXATION: Impact of Histopathology from

Hematoxylin and Eosin Stains to Immunostaining (Part II). American Society of Clinical

Pathologists Teleconference - Continuing Education, 1996.

5. Grizzle WE. Overview: It's All in the (Silver) Family. J Histotechnology (Guest

Editorial) 1996;19(3):179

6. Grizzle WE. Introduction: Biomarkers - The New Frontier in the Pathology of Invasive

and Preinvasive Neoplasias. Biotech Histochem (Editorial) 1997;72(2):59-61

7. Grizzle WE. The Use of Fixatives in Diagnostic Pathology. J Histotechnology (Guest

Editorial) 2001;24(3)151-152.

8. Grizzle WE. Review of the 2002 annual meeting of the Biological Stain Commission.

Biotech Histochem 2002; 77(4):181-182.

9. Grizzle WE. President’s Report of the Biological Stain Commission Annual Meeting

June 6-7, 2003, Rochester, New York. Biotech Histochem 2003; 78(3-4)141-144.

10. Li L, Hsu HC, Grizzle WE, Stockard CR, Ho KJ, Lott P, Yang PA, Zhang HG, Mountz

JD. Erratum. Scand J Immunol 2003; 58(1):118.

11. Hanner R, Mifflin TE, Grizzle WE. Inaugural Issue for ISBER and CPT. Cell

Preservation Technology (Editorial) 2005;3(1):3-4.

12. Grizzle WE. A critical need for increased understanding of the use of human tissues in

biomedical research. J Cancer Sci Ther 2012; 4(9):16-17. PMCID:PMC3527846.

13. Grizzle WE. Missed opportunities and lost lives: Consequences of some proposed

changes to regulations on research with human tissues-Letter. Clinical Cancer Research

2015;21(23):5404-5405

14. Demark-Wahnefried W, Nix JW, Hunter GR, Rais-Bahrami S, Desmond RA, Chacko B,

Morrow CD, Azrad M, Frugé AD, Tsuruta Y, Ptacek T, Sully SA, Segal R, Grizzle WE.

Erratum to: Feasibility outcomes of a presurgical randomized controlled trial exploring

the impact of caloric restriction and increased physical activity versus a wait-list control

on tumor characgeristics and cir culating biomarkes in men electing prostatectomy for

prostate cancer. BMC Cancer 2017 Jan 23 17(1):71 PMID 28114897 PMCID:

PMC5260118


15. Demark-Wahnefried W, Rais-Bahrami S, Desmond RA, Gordetsky JB, Azrad M, Fruge

AD, Yang ES, Norian LA, Grizzle WE. Reply to “Phase II prospective randomized trial

of weight loss prior to radical prostatectomy. Prostate Cancer and Prostatic Diseases.

April 24, 2018. https://doi.org/10.1038/s41391-018-0038-9. PMCID:PMC602611

BOOKS

1. Grizzle WE. Hypothalamic control of adrenocorticotropic hormone (ACTH) [Ph.D.

Dissertation]. The Johns Hopkins University, 1975.

2. Grizzle WE. Use of Human Tissues in Research in Matching Needs, Saving Lives:

Building a Comprehensive Network for Transplantation and Biomedical Research.

Swerdlow JL. The Annenberg Washington Program, Washington, D.C., 1989

3. Forrester K, Almoguera C, Lama C, Dunitz J, Kawanishi H, Grizzle WE, Perucho, M.

Expression and mutational activation of the c-K-ras oncogene in human colorectal

Adenomas and carcinomas. Familial Adenomatous Polyposis, (Ed. L. Herrera) Alan R.

Liss, Inc., New York, 1990;337-346.

4. Bailar JC, Gaylor D, Grizzle WE, Grumbly T, Kalman D, Mahaffey K, Matthews HB,

Perera F, Waksberg J. Monitoring Human Tissues for Toxic Substances. National

Academy Press, Washington, D.C., 1991.

5. Grizzle WE. Tissue Resources in the Detection and Evaluation of Markers, In: Early

Detection of Cancer: Molecular Markers. (Ed. S. Srivastava), SM Lippman, WK Hong,

JL Mulshine, Futura Publishing Co., Inc. 1994; 69-76.

6. Grizzle WE, Myers RB, Manne U, Stockard CR, Harkins LE, Srivastava S. Factors

Affecting Immunohistochemical Evaluation of Biomarker Expression in Neoplasia. John

Walker's Methods in Molecular Medicine - Tumor Marker Protocols, (Eds. Margaret

Hanausek and Zbigniew Walaszek), Humana Press, Inc., Totowa, NJ, 1998; 161-179.

7. Grizzle WE, Myers RB, Manne U, Srivastava S. Immunohistochemical Evaluation of

Biomarkers in Prostatic and Colorectal Neoplasia. John Walker's Methods in Molecular

Medicine - Tumor Marker Protocols, (Eds. Margaret Hanausek and Zbigniew Walaszek),

Humana Press, Inc., Totowa, NJ, 1998; 143-160.

8. Fabian CJ, Kimler BF, Elledge RM, Grizzle WE, Beenken SW, Ward JH. Models for

Early Chemoprevention Trials in Breast Cancer. Seminars in Oncology.

Hematology/Oncology Clinics of North America, Vol. 12 (No. 5), pp. 993-1017, 1998.

9. Grizzle WE, Shibata D, Manne U, Myers RB, Frost AR. Molecular and Histopathologic

Changes in the Development of Colorectal Neoplasia. In: Molecular Pathology of Early

Cancer, (Eds. S. Srivastava, D. E. Henson and A. Gazdar), IOS Press, Van Diemenstratt,

Amsterdam, Netherlands, Chapter 10, pp 135-170, 1999.

10. Grizzle WE and Sexton KC. Development of a Facility to Supply Human Tissues to Aid

in Medical Research. In: Molecular Pathology of Early Cancer, (Eds. S. Srivastava, D.

E. Henson and A. Gazdar), IOS Press, Van Diemenstratt, Amsterdam, Netherlands,

https://doi.org/10.1038/s41391-018-0038-9


Chapter 24, pp 371-383, 1999.

11. Beenken SW, Grizzle WE, Crowe DR, et al.: Molecular biomarkers for breast cancer

prognosis: Coexpression of c-erbB-2 and p53. In: Copeland EM III (ed), Year Book of

Surgery, 2002 Edition. Mosby Yearbook, St. Louis, MO, Chapter 11-1, pp. 305-307,

2002.

12. Fabian CJ, Kimler BF, Mayo MS, Grizzle WE, Masood S, Ursin G. Strategies for

Cancer Chemoprevention. Clinical Approaches to the Discovering and Testing New

Breast Cancer Prevention Drugs. In: Cancer Chemoprevention Volume 2. (Eds. Kelloff,

Hawk, Sigman), Humana Press Inc., Totowa, NJ. Chapter 17, pp 213-237, 2005.

13. Chhieng DF, Frost AR, Talley LL, Grizzle WE. Biology of Breast Cancer. Molecular

and pathologic features of ductal neoplasia of the breast: Racial Considerations. In:

Breast Cancer in Women of African Descent. (Eds. CKO Williams, CP Hunter, C

Falkson and O Olopade). Chapter 3, pp 39-70, 2005.

14. Alvarez RD, Grizzle WE, Weiss HL, Grubbs CJ, Oza A. Progress in the Development

of Effective Chemoprevention Agents for Cervical Neoplasia. In: Cancer

Chemoprevention Volume 2. (Eds. Kelloff, Hawk, Sigman), Humana Press Inc., Totowa,

NJ. pp 437-438, 2005.

15. Grizzle WE, Bell W, Fredenburgh J. Safety in biomedical and other laboratories. In:

Molecular Diagnostics. (Eds. G. Patrinos, W. Ansorg). Chapter 33, pp 421-428, 2005.

16. Grizzle WE, Semmes OJ, Bigbee WL, Malik G, Miller E, Manne B, Oelschalger DK,

Zhu L, Manne U. Use of mass spectrographic methods to identify disease processes. In:

Molecular Diagnostics. (Eds. G. Patrinos, W. Ansorg). Amsterdam, The Netherlands:

Elsevier Academic Press. Chapter 17, pp 211-222, 2005.

17. Grizzle WE, Bostwick DG, Burke H, Tawfik OW, McGregor D, Cohn J, Lieberman R.

Biomarkers in Prostate Cancer. AACR 96th

Annual Meeting, Education Book 2005: 196-

204.

18. Grizzle WE, Bell W, Sexton KC. Best practices and challenges in collecting and

processing human tissues to support biomedical research. AACR 96th

Annual Meeting,

Education Book 2005: 305-310.

19. Chhieng DC, Rodriguez-Burford C, Grizzle WE. Role of immunohistochemical

expression of Lewis Y antigen in ovarian carcinoma. In: Handbook of

Immunohistochemistry and in situ Hybridization of Human Carcinomas: Molecular

Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinoma. Volume 4. (Ed. Hayat

MA). Chapter 19, pp 465-471, 2006.

20. Grizzle WE, Fredenburgh J, Myers RB. Fixation of Tissues. In: Theory and Practice

of Histological Techniques, 6th

Edition, (Eds. J. Bancroft, M. Gamble), Churchill

Livingstone, Edinburgh, United Kingdom. Chapter 4, pp 53-74, 2007.

21. Billings, PE and Grizzle, WE. The Gross Room. In: Theory and Practice of

Histological Techniques, 6th




22. Myers RB, Fredenburgh JL, Grizzle WE. Carbohydrates. In: Theory and Practice of

Histological Techniques, 6th



23. Fredenburgh JL, Bancroft J, Grizzle WE, and Myers RB. Proteins and Nucleic Acids. .

In: Theory and Practice of Histological Techniques, 6th

Edition, (Eds. J. Bancroft, M.

Gamble), Churchill Livingstone, Edinburgh, United Kingdom. Chapter 13, pp 217-231,

2007.

24. Grizzle WE, Bancroft J. The Dispersed Neuroendocrine System, Cytoplasmic Granules,

Other Organelles. In: Theory and Practice of Histological Techniques, 6th

Edition, (Eds.

J. Bancroft, M. Gamble), Churchill Livingstone, Edinburgh, United Kingdom. Chapter

16, pp 283-307, 2007.

25. Grizzle WE, Fredenburgh JL, Myers RB. Appendices to Theory and Practice of

Histologic Techniques, 6th

Edition, (Eds. J Bancroft, M. Gamble), Churchill Livingstone,

Edinburgh, United Kingdom, pp 673-694, 2007.

26. et al Grizzle WE, et al. Report of the Public Responsibility in Medicine and Research.

The PRIM&R Human Tissue/Specimen Banking Working Group, 2007.

27. et al, Grizzle WE, et al. Section II Tools for Investigators, IRBs and Repository

Managers. The PRIM&R Tissue Working Group Report, Section II, 2008.

28. Bell WC, Sexton KC, Grizzle WE. Organizational issues in providing high-quality

human tissues and clinical information for the support of biomedical research. In:

Methods Mol Biol, (Eds. Robert Grützmann and Christian Pilarsky), 2010; 576:1-30.

29. Grizzle WE, Bell WC, Fredenburgh J. General Considerations Concerning Safety in

Biomedical Research Laboratories. In: Molecular Diagnostics, 2nd edition, (Eds.,

Patrinos GP and Ansorg W) 2010, Chapter 39, pp 563-72.

30. Srivastava S., Grizzle WE, Eds., Translational Pathology of Early Cancer, IOS Press,

BV, Amsterdam, The Netherlands 2012.

31. Grizzle WE, Srivastava S, Manne U. Translational Pathology of Neoplasia. In:

Translational Pathology of Early Cancer. (Eds. S Srivastava, WE Grizzle) IOS Press

BV, Amsterdam, The Netherlands; 2012;7-20.

32. Grizzle WE, Bell WC, Sexton KC. Issues in collecting, processing and storing human

tissues and associated information to support biomedical research. In: Translational

Pathology of Early Cancer. (Eds. S Srivastava, WE Grizzle), IOS Press BV, Amsterdam,

The Netherlands; 2012;531-549.

33. Grizzle WE, Srivastava S, Manne U. The biology of incipient, pre-invasive or

intraepithelial neoplasia. In: Translational Pathology of Early Cancer, (Eds. S

Srivastava, WE Grizzle), IOS Press BV, Amsterdam, The Netherlands; 2012;21-39.


34. Srivastava S, Grizzle WE. Biomarkers and the genetics of early neoplastic lesions. In:

Translational Pathology of Early Cancer, (Eds. S Srivastava, WE Grizzle), IOS Press

BV, Amsterdam, The Netherlands; 2012;41-64.

35. Manne U, Shanmugam C, Katkoori VR, Grizzle WE. Development and progression of

colorectal neoplasia. In: Translational Pathology of Early Cancer, (Eds. S Srivastava,

WE Grizzle), IOS Press BV, Amsterdam, The Netherlands; 2012;235-265.

36. Grizzle WE, Sexton KC, Bell WC. Human Tissue Biorepository. In: Molecular

Genetic Pathology, volume 1, 2nd

edition. (Eds. L Cheng, D. Zhang, Eble J), Springer

Science+Business Media. 2013;483-497.

37. Zhang HG, Grizzle WE. The effects of exosomes and related vesicles on cancer

development, progression and dissemination. In: Emerging Concepts of Tumor

Exosome-Mediated Cell-Cell Communication, (Eds HG Zhang), Springer Science.

2012;107-129.

38. Tinsley, H.N., Grizzle, W.E., Abadi, A.H., Keeton, A.B., Zhu, B., Xi, Y., and Piazza,

G.A. “New NSAID targets and derivatives for colorectal cancer prevention.” Invited

chapter for the book Prospects for Chemoprevention of Colorectal Neoplasia – Emerging

Role of Anti Inflammatory Drugs. (Eds Chan AT, Detering, E), Berlin, Springer,

2013;105-120.

39. Grizzle WE, Sexton KC, Bell WC. Issues in Operating a Human Tissue Resource

Supporting Biomedical Research In: Cellular Therapy: Principles, Methods and

Regulations, 2nd edition. Editors Areman E, Loper K. AABB: Bethesda, MD, 2016; 497-

509. (PMCID not required; Book Chapter).

40. Atherton DS, Sexton KC, Otali D, Bell WC, Grizzle WE. Factors affecting the use of

human tissues in biomedical research: Implications in the design and operation of a

biorepository In: Cancer Gene Profiling: Methods and Protocols,2nd

edition, editors

Grützmann R and Pilarsky C. Springer Science+Business Media, LLC: New York,

2016;1-38 (PMCID not required; Book Chapter).

41. Atherton DS, Fredenburgh J, Sexton KC, Bell WC, Grizzle WE. Safety and the

biorepository. In: Molecular Diagnostics, Third Edition, editors Patrinos G, Danielson P,

Ansorge W., Danielson PB. Elsevier: San Diego. 2016: 479-492. (PMCID not required;

Book Chapter).

42. Burke HB, Grizzle WE. Clinical Validation of Molecular Biomarkers in Translational

Medicine In: Biomarkers in Cancer Screening and Early Detection, Sudhir Srivastava,

editor, Wiley, Oxford, UK 2017: 256-266.

43. Nobis N, Grizzle W, Sodeke S. Bioethics and cancer biomarker research. In:

Biomarkers in Cancer Screening and Early Detection. (Ed. Srivastava S) Wiley, Oxford

UK Press 2017: 277-282.

44. Hewitt RE, Grizzle WE, Watson PH, Lee Y, di Donato J-H, Vaught J. Biobanking

Networks and Global Banking In: Biobanking of Human Biospecimens: Principles and

Practice, editors Hainaut P, Vaught J, Zatloukal K, Pasterk M. Springer Nature: Cham,


Switzerland 2017: 111-135.

45. Grizzle WE, Fredenburgh J, Sexton K, Bell W. Safety issues in biorepositories In:

Biobanking of Human Specimens: Principles and Practice. Editors Hainaut P, Vaught J,

Pasterk M, Zatloukal K, Pasterk M. Springer Nature: Cham, Switzerland 2017: 65-83.

(PMCID not required: Book Chapter).

Be sure to add PRIM&R IRB Textbook chapters

MISCELLANEOUS

Films, educational tapes, syllabi, software packages and courses developed, etc.

1. Endocrine Pathophysiology Syllabus for use by UAB Sophomore Medical Students,

1983-current

2. Grizzle WE et al. Cooperative Human Tissue Network Database Program

Published Abstracts/Presentations

1. Grizzle WE, Johnson RN, Schramm LP, Gann DS. Localized hypothalamic area related

to neural control of ACTH. Fed Proc 1973;32:295

2. Grizzle WE, Dallman MF, Schramm LP, Gann DS. Hypothalamic areas associated with

neural control of ACTH. Physiologist 1973;l6:330

3. Grizzle WE, Dallman MF, Schramm LP, Gann DS. Hypothalamic control of ACTH

release after hemodynamic changes. Abstracts of Short Communications, IV

International Congress of the International Society of Psychoneuroendocrinology, 1973

4. Grizzle WE, Schramm LP, Gann DS. Medication of the release of ACTH by the medial-

dorsal hypothalamus (MDH). Proceedings of the Society for Neurosciences 1974, p. 238

5. Ward DG, Grizzle WE, Gann DS. Inhibitory and facilitory areas of the rostral pons

mediating ACTH release in the cat. Endocrinology [Suppl] 1976;97:309

6. Maran JW, Carlson DE, Grizzle WE, Ward DG, Gann DS. Hypothalamic organization

for control of ACTH in the cat. Endocrinology [Suppl] 1977;l00:57

7. Siegel AL, Grizzle WE, Stabler TV. Identification of functional neoplasms of the

autonomic nervous system. Clin Chem 1982;28:l636

8. Grizzle WE, Siegel AL. Extra-adrenal pargangliomas: Biochemical, ultrastructural and

histochemical analysis. Endocrinology [Suppl] 1982;110-119

9. Dunlap NE, Grizzle WE. Urinary free cortisol as screening method of choice for


Cushing's syndrome. American College of Physicians, 1983 Annual Session. Hosp Pract

1983:18(6):37-43

10. Dunlap NE, Grizzle WE. The golden hamster: A new experimental model of

compensatory adrenal hypertrophy. Endocrinology [Suppl] 1983;112:332

11. Grizzle WE, Dunlap NE. Aldosterone blocks compensatory adrenal hypertrophy in the

rat. Endocrinology [Suppl] 1983;112:321

12. Grizzle WE, Bell DS. Islet cell hyperplasia as a cause of hypoglycemia in adult patients.

Diabetes [Suppl] 1983;32:116A

13. Robinson CA, Ketchum CH, Hall LM, Grizzle WE. LD isoenzyme VI: Clinical

properties. Clin Chem 1983;29:1168

14. Dunlap NE, Grizzle WE. Effect of aldosterone on adrenal compensatory hypertrophy in

the rat. In: Seventh International Congress of Endocrinology. Princeton: Exerpta

Medica. 1984, p. 542

15. Grizzle WE, Dunlap NE. Antagonists to aldosterone block its effect on adrenal

compensatory hypertrophy in the rat. In: Seventh International Congress of

Endocrinology. Princeton: Excerpt Medica. 1984, p. 781

16. Garg A, Grizzle WE, Stabler TV, Boots LR, Boshell BR, Kansal PC. Adrenomedullary

responses of patients with khypopituitarism to insulin induced hypoglycemia.

Endocrinology [Suppl] 1985;116:169

17. Grizzle WE, Stabler TV, Siegel AL. Evaluation of functional endocrine tumors with

emphasis on tumors of the autonomic nervous system. South Med J [Suppl] 1985;79:41

18. Chastain SL, Ketchum C, Grizzle WE. Alteration of the electrophorectic mobility of

human brain type creatine kinase (CK-BB) activity. Clin Chem 1986;32:ll29

19. Gandour MJ, Grizzle WE. An unusually small adrenal cortical carcinoma. South Med

Assoc, 80th Annual Scientific Assembly, Atlanta, GA, 1986

20. Kennedy JI, Chandler DB, Fulmer JD, Grizzle WE, Wert MB. Dietary menhaden oil

modulates bleomycin-induced pulmonary fibrosis. Markfield Symposium on Interstitial

Lung Disease, Chicago, IL, 1986

21. Ingram JT, Grizzle WE. Characterization of the effect of aldosterone on adrenal

compensatory growth in hamsters. J Cellular Biochemistry [Suppl] 1987;llA:130

22. Pillion DJ, Atchison JA, Jenkins R, Stockard CR, Clements RS, Grizzle WE. Changes

in intestinal size and weight in the streptozotocin (STZ) - diabetic rat. Diabetes [Suppl]

1987;36:125A

23. Atchison JA, Grizzle WE, Pillion DJ. Efficiency of insulin administered into the large

intestine. Diabetes [Suppl] 1987;36:125A


24. Kennedy JI, Chandler DB, Fulmer JD, Wert MB, Grizzle WE. Effects of dietary fats on

bleomycin-induced pulmonary fibrosis. Exp Lung Res 1987;12:149-161

25. Turbat-Herrera EA, Herrera GA, Gori I, Lott RA, Grizzle WE, Bonnin JA.

Neuroendocrine differentiation in prostatic carcinomas. ASCP/CAP Fall National

Meeting, New Orleans, LA, October 24-28, 1987.

26. Jones J, Sack J, Grizzle WE, Pollack WJ, Lott RC, Herrera CA, Cerezo L. Intestinal

Plexosarcoma. Lab Invest 1988:58;44A

27. Pace CS, Bucy RP, Grizzle WE, Powell KG, Delmo MC, Boshell BR. Transplantation

of pancreatic allografts into the spontaneously diabetic BB/W rat. Diabetes [Suppl]

1988;37:211A

28. Grizzle WE, Zitch RP, Hagood ML, Smith LJ, Ingram JT. The effect of lighting

regimens and the pineal gland on adrenal compensatory growth. Endocrinology [Suppl]

1988;122:103

29. Atchison JA, Grizzle WE, Pillion DJ. The effect of hemolysis on the radioimmunassay

for insulin. Diabetes [Suppl] 1988;37:134A

30. Grizzle WE, Smith LJ, Ingram JT. A commercial kit for measuring aldosterone in non-

extracted serum from rats and hamsters. Clin Chem 1988;34:1197

31. Herrera GA, Cerezo L, Jones J, Sack J, Grizzle W, Pollack WJ, Lott RA. Intestinal

plexosarcomas. International Academy of Pathology Meeting, Washington, DC,

February 28-March 3, 1988

32. Alvarez RD, Smith LJ, Miller DM, Grizzle WE. Protooncogene expression in

compensatory ovarian hypertrophy. Society for the Study of Reproduction, 1988, Seattle,

Washington

33. Perucho M, Forrester C, Almoguera S, Kahn C, Lama D, Shibata N, Arnheim N, Grizzle

WE. Expression and mutational activation of the C-Ki-ras gene in human carcinomas.

34. Pillion DJ, Atkchison JA, Grizzle WE. Colonic absorption of insulin In Vitro and In

Vivo. Proceedings of the Symposium on The Action of Insulin and Related Growth

Factors in Diabetes Mellitus, 1988, Joslin Center, Boston, MA

35. Hunter F, Oelschlager DK, Bhown AS, Grizzle WE, Bennett JC. The cellular

distribution of fodrin in murine thymocytes. American Rheumatism Association, 1989,

Cincinnati, Ohio

36. Hunter F, Oelschlager DK, Bhown AS, Bennett JC, Lott RL, Grizzle WE. Murine fodrin

distribution studied by monoclonal and polyclonal antibodies. Cell Biol 1989

37. Geer MJ, Hunter F, Bennett JC, Grizzle WE. Cellular expression of fodrin in the

developing murine cerebellum. FASEB 1989

38. Arnold P, Grizzle WE, Yang M, Pillion DJ. Altered IGF-I/insulin receptor expression in


human vs. rat adrenal tissue. FASEB 1989

39. Pillion DJ, Hayes A, Yang M, Atchison JA, Grizzle WE. Mechanism of intestinal

insulin binding and absorption. FASEB 1989

40. Carpenter G, Todderud G, Grizzle W, Nishibe S, Wahl M. EGF-induced

phosphorylation of phospholipase C-gamma. ASBMB/AA1 1990

41. Grizzle WE, Carpenter G. EGF stimulates recovery of tyrosine-phosphorylated

phospholipase C activity in a non-transformed cell line. ASBMB/AAI 1990

42. Grizzle WE, Pillion DJ. Renal receptors for insulin and IGF-1: localization and species

specificity. American Diabetes Association, 1990, Atlanta, Georgia

43. Pillion DJ, Haskell JF, Grizzle WE. Differential expression of receptors for h1GF-II on

rat and rabbit colon epithelial cells. American Diabetes Association, 1990, Atlanta,

Georgia

44. Pillion DJ, Meezan E, Grizzle WE. Localization of insulin and IGF-1 binding sites in

the human kidney: autopsy samples vs. surgical specimens. ASPET, 1990, Milwaukee,

Wisconsin

45. Meredith R, Orr R, Grizzle W, Urist M, Russell C, Wheeler R, LoBuglio A, Khazaeli

MB. Comparative localization of murine and chimeric B72.3 antibody in patients with

colon cancer. 6th International Conference on Monoclonal Antibody Immunoconjugates

for Cancer, 1991, San Diego, California

46. Pillion DJ, Yang M, Meezan E, Bartlett JD, Crain JR, Grizzle WE. Treatment of

diabetic rats with eye drops containing insulin. Association for Research in Vision and

Ophthalmology, 1991

47. Pillion DJ, Yang M, Meezan E, Bartlett JD, Crain JR, Grizzle WE. Insulin absorption

from eye drops in the rat. 14th International Diabetes Federation Congress, Washington

DC, 1991

48. Kwakye JB, Johnson MR, Barnes S, Grizzle WE, Diasio RB. Identification of bile acid

CoA: Amino acid: N-Acyltransferase in human kidney. National Association of

Gastroenterology, Annual Meeting, 1991

49. Romeo GM, Kwayke J, Barnes S, Diasio RB, Johnson M, Grizzle WE.

Immunohistochemical localization of bile acid CoA: Amino acid: N-Acyltransferase in

human and rat livers. National Association of Gastroenterology, Annual Meeting, 1991

50. Dropcho EJ, Saleh MN, Grizzle WE, Oh SJ. Peripheral Neuropathy Following

Treatment of Melanoma with a Murine Anti-GD2 Monoclonal Antibody (MoAb).

American Academy of Neurology, 1991

51. Grizzle WE, Saleh M, Stockard CR, LoBuglio AF. Pathologic Changes in the Human

Gastrointestinal Tract Secondary to Immunotherapy with the Monoclonal Antibody

D612. American Association for Cancer Research, 1991


52. Myers RB, Kudlow JE, Grizzle WE. Expression of Transforming Growth Factor Alpha,

Epidermal Growth Factor and the Epidermal Growth Factor Receptor in Benign Prostatic

Hyperplasia and Prostate Cancer. Endocrine Society Annual Meeting, 1992

53. Parker CR, Stankovic A, Grizzle WE, Dion D. The Effects of TGF-Beta on Growth and

Steroidogenesis of Non-Confluent Primary Cultures of Human Fetal Adrenal Cells.

Ninth International Congress of Endocrinology, Nice, France, 1992.

54. Myers RB, Oelschlager D, Srivastava S, Grizzle WE. TGFα is Strongly Expressed in

Metastatic Prostatic Adenocarcinoma. 87th Annual Scientific Assembly of the Southern

Medical Association, 1993. S Med J 1993;86(9):S103-S104.

55. Myers RB, Oelschlager D, Srivastava S, Grizzle WE. Primary Tumors from Patients

with Metastatic Prostatic Adenocarcinoma Have Higher Rates of p53 Mutations than

Non-Metastatic Primary Tumors. 87th Annual Scientific Assembly of the Southern

Medical Association, 1993. S Med J 1993;86(9):S-103.

56. Myers RB, Grizzle WE. Effects of Retinoic Acid on the Growth of Malignant Human

Prostatic Cell Lines. United States and Canadian Academy of Pathology, Annual

Meeting, 65A, 1993.

57. Parker MLW, Grizzle WE. Immunohistochemical Localization of EGF, TGFα, and the

EGF Receptor in Renal Cell Carcinoma. United States and Canadian Academy of

Pathology, Annual Meeting, 66A, 1993.

58. Parker, CR, Stankovic A, Falany, CN, Comer KA, Grizzle WE, Stockard CR, Dion LD.

Dehydroepiandrosterone Sulfotransferase: Cellular Localization and Regulation of

Expression in Cultured Human Fetal Adrenal Cells. Society for Gynecologic

Investigation, 1993 Annual Meeting, Oral Presentation.

59. Parker CR, Falany C, Stankovic AK, Stockard CR, Grizzle WE. Immunohistochemical

Localization of DHEA-Sulfotransferase (DST) in Human Fetal Tissues. Society for

Gynecologic Investigation, 1993 Annual Meeting, Poster Session.

60. Arnold M, Myers R, Stockard C, Fredenburgh J, Srivastava S, Grizzle W. Effect of

fixatives on demonstration of keratin, neu p53, and B72.3 in paraffin embedded tumor

tissues. 1994 Annual Meeting, United States and Canadian Academy of Pathology.

Modern Pathol 1994;7(1):161A.

61. Grizzle WE, Myers RB, Oelschlager D, Srivastava S. TGFα Expression is a Relatively

Late Event in the Progression of Prostatic Adenocarcinoma. 1994 Keystone Symposia on

Molecular and Cellular Biology. J Cell Biochem 1994;(Suppl)18D:230

62. Grizzle WE, Myers RB, Arnold MM, Srivastava S. Evaluation of Biomarkers in Breast

and Prostate Cancer. 1994 Quantitative Pathology in Chemoprevention Trials:

Standardization and Quality Control of Surrogate Endpoint Biomarker Assays for Colon,

Breast and Prostate. J Cell Biochem, 1994;(Suppl)19:259-266

63. Beenken S, Huang P, Sellers M, Listinsky C, Stockard C, Hubbard W, Wheeler R,


Grizzle WE. Retinoid Modulation of Biomarkers in Oral Leukoplakia/Dysplasia. 1994

Quantitative Pathology in Chemoprevention Trials: Standardization and Quality Control

of Surrogate Endpoint Biomarker Assays for Colon, Breast and Prostate,

1994;(Suppl)19:270-277

64. Myers RB, Parker MW, Grizzle WE. The Effects of Coumarin and Suramin on the

Growth of Malignant Cell Lines. 1994 German Cancer Congress. The Effects of

Coumarin and Suramin on the Growth of Malignant Cell Lines. J Cancer Res Clin

Oncol, Springer-Verlag 1994 Suppl 120:S11-S13

65. Parker CR, Faye-Petersen O, Grizzle WE. Ontogeny and Cellular Localization of

Immunoreactive 3β Hydroxysteroid Dehydrogenase in the Human Fetal Adrenal. IX

International Congress on Hormonal Steroids, 1994, B-113, p. 97

66. Myers RB, Srivastava S, Grizzle WE. Lewis Y Antigen as Detected by the Monoclonal

Antibody BR96 is Expressed Strongly in Prostatic Adenocarcinomas. 1994 American

Association for Cancer Research Sponsored Basic and Clinical Aspects of Prostate

Cancer Meeting

67. Myers RB, Oelschlager D, Srivastava S, Grizzle WE. erbB-2 and erbB-3 are Expressed

Distinctively in PIN and Invasive Prostatic Adenocarcinomas. Proc Am Assoc Cancer

Res, 1994

68. Sellers M, Grizzle W, Huang P, Peters G, Listinsky C, Stockard C, Hubbard W. Wheeler

R, Beenken S. Modulation of TGFα and Leukoplakia by 13-cis Retinoic Acid. 85th

Annual Meeting of the American Association for Cancer Research, 1994

69. Fisher K, Waites K, Utz C, Grizzle W. Importance of Microbial Cultures in the Adult

Postmortem Examination. American Society for Microbiology Meeting, 1994

70. Urban D, Grizzle WE, Coward L, Kirk M, Barnes S. A Clinical Trial of the

Chemopreventive Effect of a Soy Beverage in Men at High Risk for Prostate Cancer.

First International Symposium on Soy and Prevention of Chronic Diseases, 1994

71. Stankovic AK, Falany CN, Grizzle WE, Parker CR. Effects of Tumor Necrosis Factor-α

(TNF-α) on Growth and the Steroid Biosynthetic Pathway of Human Fetal Adrenal Cells.

1994 Annual Meeting, Society for Gynecologic Investigation

72. Perucho M, Srivastava S, Myers RB, Grizzle WE. Mutations in ras and Microsatellite

Genetic Instability are Uncommon Events in the Pathogenesis of Prostatic

Adenocarcinomas. 1994 American Association for Cancer Research Sponsored Basic

and Clinical Aspects of Prostate Cancer Meeting

73. Myers RB, Srivastava S, Oelschlager DK, Grizzle WE. Serum Levels of erbB-2 Protein

in Patients with Prostatic Adenocarcinoma. 1995 Annual Meeting of the American

Association for Cancer Research. Abstract #3839

74. Myers RB, Marshall ME, Oelschlager DK, Grizzle WE. An EGF-Diphtheria Fusion

Protein Kills the Prostate Cancer Cell Lines DU145 and LNCaP. 1995 Annual Meeting

of the American Association for Cancer Research. Abstract #2551


75. Saleh M, LoBuglio A, Sugarman S, Murray J, Onetto N, Warner G, Mezza L, Davidson

T, Grizzle W, Daniel C, LeBherz D, Healey D, Baron T, van Leeuwen D, Canetta R,

Hellstrom K. Gastrointestinal Effects of Chimeric BR96-Doxorubicn (DOX) Conjugate.

86th

Annual Meeting of the American Association for Cancer Research, March 18-22,

Toronto, Ontario, Canada. Abstract #2876

76. Listinsky CM, Huang S, Sellers MT, Wheeler R, Grizzle W, Beenken S. p53 Antigen

Overexpression in Patients with Dysplastic Oral Leukoplakia: Lack of Response to

Treatment with 13-CIS Retinoid Acid. 1995 Annual Meeting, United States and

Canadian Academy of Pathology

77. Lamartiniere CA, Zhang J, Brown NM, Coan PW, Barnes S, Grizzle WE. Selective

Cellular Proliferation of the Dorsolateral Prostate over the Ventral Prostate in Rats

Treated Chronically with Testosterone and Estradiol. International Congress of

Toxicology, Seattle, WA, 1995

78. Parker CR, Faye-Petersen O, Mason JI, Grizzle WE, Falany CN, Stankovic AK.

Ontogeny and Topology of 3β-Hydroxysteroid Dehydrogenase (HSD) and

Dehydroepiandrosterone Sulfotransferase (DST) in the Fetal and Adult Human Adrenal.

1995 Annual Meeting, The Society for Gynecologic Investigation

79. Stankovic AK, Falany CN, Grizzle WE, Parker CR. Effects of Tumor Necrosis Factor-α

(TNF-α) on Growth and the Steroid Biosynthetic Pathway of Human Fetal Adrenal Cells.

1995 Annual Meeting, Society for Gynecologic Investigation

80. Sekar MC, Sambandam V, McDonald JM, Grizzle WE, Stockard CR, Berry R.

Dissociation of Cyclic Inositol Phosphohydrolase Activity from Annexin III Binding.

American Society for Cell Biology, 1995

81. Verran DJ, Stockard CR, Grizzle W, Herrera G, Diethelm AG, Thompson JA.

Immunolocalization of FGF-1 and FGFR-1 in Rejected Human Renal Allograft Tissue.

Transplantation and Associated Immunology, 1995

82. Meredith R, Wheeler R, Khazaeli M, Plott G, Russell C, Liu T, Grizzle W, Schlom J,

LoBuglio A. Interferon Enhanced Dual 131

I-Antibody Therapy for Metastatic Colon

Cancer. 10th International Conference on Monoclonal Antibody Immunoconjugates,

San Diego, 1995

83. Myers RB, Oelschlager D, Srivastava S, Grizzle WE. Expression of nm23-H1 in

Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma. 1996 Annual Meeting,

United States and Canadian Academy of Pathology. Modern Pathol 1(1):78A, 1996

84. Manne U, Myers RB, Moron C, Srivastava S, Grizzle WE. p53 and bcl-2 Protein

Expression in Colorectal Cancer. 1996 Annual Meeting, United States and Canadian

Academy of Pathology. Modern Pathol 1(1):62A, 1996

85. Manne U, Myers RB, Moron C, Srivastava S, Grizzle WE. Racial Distribution of p53

Mutations in Colorectal Adenocarcinoma. 1996 Annual Meeting, United States and

Canadian Academy of Pathology. Modern Pathol 1(1):62A, 1996


86. Roye GD, Myers RB, Beenken, SW, Grizzle WE. CD44H Expression in Dysplastic and

Malignant Lesions of the Esophagus. 1996 Annual Meeting, United States and Canadian

Academy of Pathology. Modern Pathol ((1):64A, 1996

87. Listinsky JJ, Listinsky CM, Myers RB, Grizzle WE, DeMuth PA, Lawing LF, Siegal

GP. α-Fucosidase Reduces the Invasiveness of DU-145 Prostate Carcinoma Cells In

Vitro. Modern Pathol ((1):147A, 1996

88. Urban D, Grizzle WE, Coward L, Kirk M, Barnes S. A Clinical Trial of the

Chemopreventive Effect of a Soy Beverage in Men at High Risk for Prostate Cancer.

First International Symposium on Soy and Prevention of Chronic Diseases, 1995

89. Myers RB, Manne U, Grizzle WE, Deshane J, Wright M, Curiel DT. Intracellular

Antibody Mediated Down-Regulation of p185erbB-2

Expression in Malignant Prostatic

Cells. Proc Amer Assoc Cancer Res 37:342A, 1996

90. Myers RB, Oelschlager DK, Conway-Myers BA, Grizzle WE. The Effects of

Dihydrostestosterone on the Expression of p185erbB-2

in the Prostatic Cell Line LNCaP.

Proc Amer Assoc Cancer Res 37:224A, 1996

91. Myers RB, Hockett RD, Rogers MD, Oelschlager DK, Grizzle WE. Androgen Mediated

Expression of c-erbB-2 mRNA and Protein in the LNCaP Cell Line. 10th International

Congress of Endocrinology, P1-92 1:157, 1996

92. Manne U, Brown D, Myers RB, Perucho M, Srivastava S, Moron C, Grizzle WE. Racial

Distribution and p53 Abnormalities in Mucinous and Non-Mucinous Colorectal

Adenocarcinomas. Proc Amer Assoc Cancer Res 37:253A, 1996

93. Roye GD, Myers RB, Beenken SW, Grizzle WE. Fatty Acid Synthetase Expression in

Malignant and Premalignant Lesions of the Esophagus. Proc Amer Assoc Cancer Res

37:493A, 1996

94. Myers RB, Oelschlager DK, Poczatek RB, Srivastava S, Grizzle WE. The Expression of

the Androgen Regulated Enzyme Fatty Acid Synthetase in Prostatic Intraepithelial

Neoplasia and Prostatic Adenocarcinoma. 10th International Congress of Endocrinology,

P1-93 1:158, 1996

95. Myers RB, Oelschlager DK, Poczatek RB, Srivastava S, Grizzle WE. Fatty Acid

Synthetase is Expressed in Prostatic Intraepithelial Neoplasia and Prostatic

Adenocarcinoma and is Regulated by Sex Steroids. 1996 International Symposium on

Biology of Prostate Growth, March 28-31, 1996, Washington, DC

96. Myers RB, Hockett R, Rogers MD, Srivastava S, Grizzle WE. Effects of Androgens on

the Expression of c-erbB-2 mRNA and Protein in the LNCaP Cell Line. 1996

International Symposium on Biology of Prostate Growth, March 28-31, 1996,

Washington, DC

97. Meredith R, Alvarez R, Partridge E, Khazaeli M, Plott G, Macey D, Russell C, Liu T,

Grizzle W, Schlom J, LoBuglio A. Intraperitoneal Radioimmunotherapy of Ovarian


Cancer with 177

LU-CC49. Sixth Conference on Radioimmunodetection and

Radioimmunotherapy of Cancer. Princeton, NJ, 1996

98. Raben D, Buchsbaum DJ, Mikheeva G, Grizzle WE, Khazaeli MB, Rogers B, Curiel

DT, Garver RL Jr. A Strategy to Augment Efficacy of Genetic Radiation

Immunotherapy by Use of Conditionally Replication-Enabled Adenovirus. Fifth

International Conference on Gene Therapy of Cancer sponsored by the American

Association for Cancer Research. San Diego, CA, 1996

99. Alvarez R, Partridge E, Khazaeli M, Plott G, Russell C, Liu TP, Grizzle W, Schlom J,

LoBuglio A, Meredith R. Intraperitoneal Radioimmunotherapy of ovarian Cancer with 177

Lu-CC49: A Phase I Study. Society of Gynecologic Oncology, 1996

100. Manne U, Shibata D, Tsao J, Srivastava S, Grizzle WE. p53 Nuclear Accumulation

(p53NA), Bcl-2 Expression and Clinicopathological Characteristics of Primary

Colorectal Adenocarcinomas (CAC) with Microsatellite Instability (MSI). Proc Amer

Assoc Cancer Res 38: (Abstract #1003), 1997

101. Roland P, Myers RB, Conner MG, Manne U, Alvarez RD, Grizzle WE. CD44

Expression in Cervical Dysplasia. Proc Amer Assoc Cancer Res 38:108A, 1997

102. Poczatek RB, Myers RB, Manne U, Bostwick DG, Grizzle WE. Expression of the

323/A3 Tumor-Associated Antigen in Prostatic Adenocarcinoma and Prostatic

Intraepithelial Neoplasia. Proc Amer Assoc Cancer Res 38:427A, 1997

103. Krontiras H, Roye GD, Myers RB, Beenken SE, Grizzle WE. Fatty Acid Synthetase

Overexpression Correlates with Malignant Phenotype in Carcinomas of the Oral Tongue.

Proc Amer Assoc Cancer Res 38:541A, 1997

104. Rogers BE, Curiel DT, Khazaeli MB, Grizzle WE, Laffoon K, McLean S, Buchsbaum

DJ. Radiolabeled Ligand Binding to Cells Induced to Express the Epidermal Growth

Factor Receptor Using a Recombinant Adenoviral Vector. J Nuclear Med, 38:18P, 1997

105. Swanson SM, Whitaker LM, Stockard CR, Myers RB, Oelschlager D, Grizzle WE,

Grubbs CJ. Hormone Levels and Mammary Epithelial Cell Proliferation and

Differentiation in Rats Treated with a Chemopreventative Regimen of Estradiol and

Progesterone (E&P). Proc Amer Assoc Cancer Res 38:370A, 1997

106. Sekar MC, Stockard C, Grizzle W, Ernst J. Ductal Distribution of Annexin III.

Experimental Biology Annual Meeting, Abstract #10199, 1997

107. Meredith R, Alvarez R, Partridge E, Khazaeli MB, Grizzle W, Schlom J, LoBuglio A.

Enhanced Intraperitoneal Radioimmunotherapy with Adjuvant Interferon and Taxol.

Amer Soc Therapeutic Radiology & Oncology Annual Meeting, Oct., 1997

108. Meredith R, Alvarez R, Partridge E, Khazaeli MB, Grizzle W, May M, Schlom J,

LoBuglio A. Enhanced Intraperitoneal Radioimmunotherapy (RIT) of Ovarian Cancer.

Proceedings American Association for Cancer Research, 39:324, 1998

109. Myers RB, Manne U, Frost AR, Grizzle WE, LeBoeuf RD. Expression of Suppressin in


Neoplasia of the Breast. Proceedings American Association for Cancer Research

(Abstract #4241) 39:623, 1998

110. Myers RB, Lieberman R, Kelloff GJ, Grizzle WE. Effects of Chemopreventive Agents

on the Growth of Prostatic Adenocarcinoma Cell Lines In Vitro. Proceedings American

Association for Cancer Research (Abstract #1320) 39:193, 1998

111. Myers RB, Oelschlager DK, Pretlow T, Coan PN, Grizzle WE. Expression of p21 and

p27 During Castration Induced Regression of Prostatic Adenocarcinoma. Proceedings

American Association for Cancer Research (Abstract #90) 39:14, 1998

112. Manne U, Myers RB, Oelschlager D, Weiss HL, Perucho M, Grizzle WE. Association

Between the Amount of Mucin and p53 Abnormalities in Colorectal Adenocarcinomas.

Proceedings American Association for Cancer Research (Abstract #3734) 39:549, 1998

113. Manne U, Myers RB, Sekar CM, Grizzle WE. Differential Growth Inhibitory Effects of

Inositol Hexophosphate on Colon Cancer Cell Lines. Proceedings American Association

for Cancer Research (Abstract #4078) 39:599, 1998

114. Manne U, Oelschlager D, Grizzle WE, LeBoeuf RD. Expression of Suppressin, a

Candidate Tumor Suppressor Gene, in Colorectal Adenocarcinomas. Proceedings

American Association for Cancer Research (Abstract #4242) 39:623, 1998

115. Beenken SW, Manne U, Myers RB, Weiss H, Krontiras H, Malone W, Peters GE, Kelloff

GJ, Grizzle WE. Increased Expression of Transforming Growth Factor-Alpha,

Epidermal Growth Factor Receptor, erbB-2 and erbB-3 in Dysplastic Leukoplakia. Amer

Soc Clin Oncol, Los Angeles, CA, May 16-19, 1998.

116. Myers RB, Oelschlager DK, Manne U, Coan P and Grizzle WE. Androgen Regulation

of Growth Factor Receptor in Prostatic Carcinoma. Am Soc Cell Biol 38:661, 1998

117. Piyathilake CJ, Manne U, Heimburger DC, Weiss H, Frost AR, Grizzle WE. TGF-α

Expression in Epithelial Hyperplasia/Dysplasia and Invasive Squamous Cell Carcinoma

(SCC) in the Human Lung. American Society of Preventive Oncology, 1998 Annual

Meeting, March 4-6, 1998, Bethesda, MD

118. Roland PY, Alvarez RD, Grizzle WE, Myers RB, Barnes M, Kilgore LC, Partridge EE.

The Chemopreventive Agent Sulindac Modulates Expression of TGF-α and EGF-

Receptor in the Uterine Cervix. Society of Gynecologic Oncologists 29th Annual

Meeting, 1998

119. Stackhouse MA, Buchsbaum DJ, Grizzle WE, Bright S, Olsen C, Kancharla S, Mayo

MS, Curiel DT. Radiosensitization Mediated by an Anti-erbB-2 Single Chain Antibody

In Vitro and In Vivo. Tenth International Conference on Chemical Modifiers,

Clearwater, FL, January 28-31, 1998

120. Mixon RL, Brissie RM, Grizzle WE, Thomas J, Faye-Petersen O, Parker CR, Jr.

Immunohistochemical Studies on 3β-Hydroxysteroid Dehydrogenase in the Adult Human

Adrenal. 45th Annual Meeting The Society for Gynecological Investigation, March 11-

14, 1998


121. Pederson LC, Beenken SW, Manne U, Myers RB, Weiss H, Malone W, Peters GE,

Kelloff GJ, Grizzle WE. Changes in the Expression of p185erbB-2

in Dysplastic

Leukoplakia. Fifth Research Workshop on the Biology, Prevention and Treatment of

Head and Neck Cancer, August 28-30, 1998

122. Myers RB, Oelschlager DK, Frost A, Grizzle WE. Expression of Fatty Acid Synthetase

During Castration Induced Regression of Prostatic Adenocarcinoma. Proceedings Am

Assoc Cancer Res (Abstract #430) 65, 1999

123. Manne U, Oelschlager DK, Gary BD, Frost AR, Weiss HL, LeBoeuf RD, Grizzle WE.

Altered Subcellular Localization of Suppressin a Novel Inhibitor of Cell-Cycle Entry, is

an Independent Prognostic Factor in Colorectal Adenocarcinomas (CRC). Proceedings

Am Assoc Cancer Res (Abstract #4613) 698, 1999

124. Gibbons MD, Manne U, Carroll WR, Peters GE, Weiss HL, Grizzle WE. Phenotypic

Expression of p185erbB-2

in Malignant Salivary Gland Tumors. Proceedings Am Assoc

Cancer Res (Abstract #1269) 191, 1999

125. Urban D, Myers R, Manne U, Weiss H, Mohler J, Poulin N, Grubbs C, Lieberman R,

Kelloff G, Grizzle W. Evaluation of Biomarker Modulation by Fenretinide (4-HPR) in

Prostate Cancer Patients. Proceedings Am Assoc Cancer Res (Abstract #2849) 431, 1999

126. Poulen N, Grizzle W, Lieberman R, Kelloff G, Beenken S. Prospective Analysis and

Correlation of Nuclear Morphometry and Immunohistochemistry in DCIS and Minimally

Invasive Breast Carcinoma. Proceedings Am Assoc Cancer Res (Abstract #2844) 430,

1999

127. Buchsbaum DJ, Grizzle WE, Curiel DT, Garver RI, Jr. A Strategy to Augment

Expression of Carcinoembryonic Antigen by Use of Conditionally Replication-Enabled

Adenovirus. Therapeutic Approaches Employing Replicative Viral Systems Meeting,

Sponsored by New York Academy of Sciences, 1999

128. Piyathilake CJ, Oelschlager DK, Heimburger DC, Cornwell PE and Grizzle WE. The

Accumulation of Ascorbic Acid by Squamous Cell Cancers of the Lung, Larynx and Oral

Cavity. 2nd

International Conference on Anti-oxidants and Free Radicals in Health and

Disease, Vancouver, BC, 1999.

129. Buchsbaum DJ, Rogers BE, Raben D, Garver RI Jr., Grizzle WE, Khazaeli MB, Curiel

DT. Genetic Radioisotope Targeting Strategies for Cancer Localization and Therapy.

American Society of Gene Therapy, 1999

130. Hockett R, Grizzle W, Perloff M, Malone W, Beenken S. Prospective Analysis of

TGFα, EGFr and erbB-2 mRNA Expression by Quantitative RT-PCR in Dysplastic Oral

Leukoplakia During Treatment with 13-cis Retinoic Acid. American Association for

Cancer Research 1999 Annual Meeting

131. Rodriguez-Burford C, Lubet RA, Steele VE, Eto I, Grizzle WE, Johanning GL, Stockard

CR, Kelloff GJ, Grubbs CJ. Effect of reduced body weight gain (BWG) in

chemoprevention studies using the methylnitrosourea (MNU)-induced mammary cancer


model. Proc Amer Assoc Cancer Res 1999;40:653

132. Frost AR, Sparks D, Grizzle WE. Comparison of Low Temperature (LTAR) and

Microwave antigen Retrieval (MAR) Methods in Immunohistochemical Staining of

Breast Cancers. American Association for Cancer Research 1999 Annual Meeting

133. Hosein T, Myers RB, Bell WC, Oelschlager DK, Grizzle WE. The Potential Role of the

MAP Kinase Pathway in the Response of LNCaP Cells to Androgens. American

Association for Cancer Research Annual Meeting, San Francisco, CA, April 1-5, 2000

134. Bonner J, Robert F, Raisch K, Saleh M, Buchsbaum D, Stackhouse M, LoBuglio A,

Meredith R, Spencer S, Grizzle W, Waksal H. The Epidermal Growth Factor (EGFr) as

a Therapeutic Target in Squamous Cell Malignancies. Radiation Research Society

Annual Meeting, 2000.

135. Manne U, Weiss H, Grizzle WE. Bcl-2 Expression is Associated with Improved

Prognosis in African-Americans and Caucasians with Distal Colorectal Adenocarcinomas

(CRCs). American Association for Cancer Research Annual Meeting, San Francisco,

CA, April 1-5, 2000. Abstract #3789

136. Burford-Rodriguez C, Myers RB, Oelschlager DK, Grizzle WE and Barnes M. Effects

of Aspirin, Acetaminophen and a Cox-II Inhibitor on Cell Lines of Ovarian Cancer.

American Association for Cancer Research Annual Meeting, San Francisco, CA, April 1-

5, 2000. Abstract #3155

137. Talley LI, Frost AR, Bell WC, Zaidi SN, Waterbor J, Grizzle WE. Correlation of

Proliferation, p27, and Estrogen Receptor (ER) in DCIS and Invasive Ductal Carcinomas

(IDC) in Pre- and Post-Menopausal Women. American Association for Cancer Research

Annual Meeting, San Francisco, CA, April 1-5, 2000. Abstract #2091

138. Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE. The

Expression of Ep-CAM (17-1A) is Associated with Progression of Squamous Cell

Carcinoma of the Lung. American Association for Cancer Research (Abstract #4391),

319, 2000

139. Piyathilake CJ, Bell WC, Johanning GL, Cornwell PE, Heimburger DC, Grizzle WE.

The Accumulation of Ascorbic Acid by Squamous Cell Cancers of the Lung and Larynx

Enhances Global Methylation of DNA. American Association for Cancer Research

Annual Meeting, San Francisco, CA, April 1-5, 2000, Abstract #3173

140. Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE,

Heimburger DC, Niveleau A. Immunohistochemical Evaluation of Global DNA

Methylation: Comparison with In Vitro Radiolabeled Methyl Incorporation Assay.

American Association for Cancer Research (Abstract #3174), 250, 2000

141. Buck RH, Robert F, Meredith RF, Grizzle WE, Khazaeli MB, LoBuglio AF. Phase I

Study of 90

Y-CC49 Monoclonal Antibody (Mab) Therapy in Patients with Advanced

Non-Small Cell Lung Cancer (NSCLC). American Association for Cancer Research

Annual Meeting, San Francisco, CA, April 1-5, 2000. Abstract #4031


142. Poulin N, Grizzle W, Lieberman R, Kelloff G, Beenken S. Prospective Analysis and

Correlation of Nuclear Morphometry and Immunohistochemistry in DCIS and Minimally

Invasive Breast Carcinoma. American Association for Cancer Research Annual Meeting,

San Francisco, CA, April 1-5, 2000

143. Gustin A, Manne U, Myers RB, Weiss H, Peters GE, Perloff M, Malone W, Grizzle WE,

Beenken SW. Increased Expression of Transforming Growth Factor-Alpha, Epidermal

Growth Factor Receptor, erbB-2 and erbB-3 in Dysplastic Oral Leukoplakia. American

Association for Cancer Research Annual Meeting, San Francisco, CA, April 1-5, 2000

144. Gustin AN, Johnson MR, Miller CR, Diasio RB, Grizzle WE, Vickers SM, Buschbaum

DJ. Quantitation of Cytosine Deaminase and Adenovirus by Real Time RT-PCR: A

Novel Method for Assessing Expression Levels in Gene Therapy. American Association

for Cancer Research Annual Meeting, San Francisco, CA, April 1-5, 2000. Abstract

#4254

145. Frost A, Myers R, Manne U, Weiss H, Urist M, Heslin M, Grizzle W, Beenken SW.

Evaluation of erbB-2, TGF-Alpha and PCNA Expression in a Study of

Difluromethylornithine (DFMO) in Patients with Breast Ductal Carcinoma In Situ.

American Society for Clinical Oncologists Annual Meeting, 2000.

146. Urban DA, Weiss HL, Grizzle WE, Beenken SW, Cronin K, Kelloff GJ, Liberman R.

Application of Bayesian Methods in the Monitoring of A Phase II Chemoprevention Trial

of 4HPR in Prostate Cancer. American Association for Cancer Research Annual

Meeting, San Francisco, CA April 1-5, 2000. Abstract #2614

147. Johanning FW, Khazeali MB, Strong TV, Grizzle WE, LoBuglio AF. Human

Endogenous Retrovirus, HERV-K 10, is Expressed in Human Breast Cancer. American

Association for Cancer Research Annual Meeting, San Francisco, CA April 1-5, 2000.

Abstract #4442

148. Gustin A, Manne U, Myers R, Weiss H, Peters G, Perloff M, Malone W, Dixon P,

Grizzle WE, Beenken S. Increased Phenotypic Expression of TGF- and EGF Receptor

in Dysplastic Oral Leukoplakia. (Presented at American Society of Clinical Oncologists

Annual Meeting, May, 2000)

149. Talley L, Zaidi SN, Frost, AR, Grizzle WE. p27, Estrogen Receptor and Proliferation in

Breast Carcinomas in Pre- and Post-Menopausal Women. United States and Canadian

Academy of Pathology, Annual Meeting, 2000.

150. Zinn KR, Buchsbaum DJ, Chanudhuri TR, Mountz JM, Grizzle WE, Rogers BE. 99m

Tc-

P2045: A New Peptide for Imaging Somatostatin Receptor Gene Transfer. Proceedings

Am Assoc Cancer Res (Abstract #318), Vol. 41(5), p. 81, 2000

151. Piyathilake CJ, Oelschlager DK, Heimburger DC, Cornwell PE, Grizzle WE. The

Accumulation of Ascorbic Acid by Squamous Cell Cancers of the Lung, Larynx, and

Oral Cavity. FASEB: Experimental Biology 2000, Vol. 14(4), Abstract #166.11, March

15, 2000

152. Piyathilake CJ, Frost AR, Manne U, Weiss H, Heimburger DC, Grizzle WE. Elevated


Expression of Fatty Acid Synthase (FASE) in Squamous Cell Cancer of the Lung.

FASEB: Experimental Biology 2000, Vol. 14(4), Abstract #552.1, March 15, 2000

153. Piyathilake CJ, Johanning GL, Macaluso JM, Whiteside MA, Oelschlager DC,

Heimburger DC, Grizzle WE. Localized Folate and Vitamin B-12 Deficiency in

Squamous Cell Lung Cancer is Associated With Global DNA Hypomethylation.

FASEB: Experimental Biology 2000, Vol. 14(4), Abstract #337.11, March 15, 2000

154. Manne U, Jhala N, Jones J, Weiss H, Grizzle WE. Prognostic Markers of Colorectal

Adenocarcinoma - Nuclear Accumulation of p53, Expression of Bcl-2, MUC1 and

Suppressin: Effect of Ethnicity and Anatomic location. Proceeding of the Early

Detection Network Meeting, Chicago, IL, September 26 – 28, 2000.

155. Beenken SW, Grizzle WE, Crowe DR, Conner MG, Weiss HL, Sellers MT, Krontiras H,

Urist MM, Bland KI. Molecular Biomarkers for Breast Cancer Prognosis: Co-

expression of c-erbB-2 and p53. Southern Surgical Association Annual Meeting,

December 4, 2000.

156. Talley LI, Grizzle WE, Waterbor JW, Frost AR. Comparison of estrogen and

progesterone receptors, p27, and K67 in histologically normal tissue, ductal carcinoma in

situ (DCIS) and invasive carcinomas in younger versus older women. Abstract #39, 92nd

Annual Meeting of the American Association for Cancer Research, New Orleans, LA,

March 24 – 28, 2001.

157. Frost AR, Bell WC, Niwas S, Talley LI, Moore-Ali G, Grizzle WE. erbB-2, epidermal

growth factor receptor (EGFR), Bcl-2 and p53 in breast carcinomas in younger and older

women. Abstract #43, 92nd

Annual Meeting of the American Association for Cancer

Research, New Orleans, LA, March 24 – 28, 2001.

158. Miller CR, Buchsbaum DJ, Williams CR, Kiss P, Elgavish G, Grizzle WE, Diasio RB,

Johnson MR, Gillespie GY. Cytosine Deaminase/5-Fluorocytosine Therapy for

Gastrointestinal (GI) and Non-GI Malignancies. Abstract #150, 92nd

Annual Meeting of

the American Association for Cancer Research, New Orleans, LA, March 24 – 28, 2001.

159. Meredith RF, Alvarez R, Partridge E, Khazaeli MB, Austin JM, Kilgore L, Grizzle WE,

Schlom J, LoBuglio A. Phase I Studies of Combined Modality Intraperitoneal Therapy

of Ovarian Cancer. Abstract #251, 92nd

Annual Meeting of the American Association for

Cancer Research, New Orleans, LA, March 24 – 28, 2001.

160. Rodriguez-Burford C, Chhieng DC, Stockard CR, Barnes MN, Alvarez RD, Partridge

EE, Weiss HL, Grizzle WE. Association Between p53 and ErbB-2 in Primary and

Matched Metastatic Lesions of Ovarian Carcinoma. Abstract #1177, 92nd

Annual

Meeting of the American Association for Cancer Research, New Orleans, LA, March 24

– 28, 2001.

161. Manne U, Sprague AP, Jones WT, Hardin JM, Grizzle WE. Use of Artificial

Intelligence (AI) and Computational Statistical (CS) Methods in Predicting the Clinical

Outcome of Colorectal Cancer (CRC) Patients. Abstract #1534, 92nd

Annual Meeting of

the American Association for Cancer Research, New Orleans, LA, March 24 – 28, 2001.


162. Jhala NC, Manne U, Gary B, Talley L, Weiss HL, Grizzle WE. Nuclear Accumulation

of p53 in Colorectal Adenocarcinoma: Prognostic Importance Differs with Race, Age and

Location of the Tumor. Abstract #2692, 92nd

Annual Meeting of the American

Association for Cancer Research, New Orleans, LA, March 24 – 28, 2001.

163. Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.

Differential expression of growth factors in squamous cell carcinoma and pre-cancerous

lesions of the lung. Abstract #2790, 92nd

Annual Meeting of the American Association

for Cancer Research, New Orleans, LA, March 24 – 28, 2001.

164. Kimler BF, Zalles CM, Masood S, Kitchen J, Grizzle WE, Arneson DW, Mayo MS,

Fabian CJ. Phase II Chemoprevention Trial of -Difluoromethylornithine (DFMO) in

Women at High Risk for Breast Cancer: Surrogate Endpoint Biomarkers. Abstract #2790,

92nd

Annual Meeting of the American Association for Cancer Research, New Orleans,

LA, March 24 – 28, 2001.

165. Rodriguez-Burford C, Jones J, Partridge EE, Zhou T, Grizzle WE. The effects of a

novel anti-human DR5 monoclonal antibody in ovarian carcinoma cells. Ninth annual

SPORE Investigator’s Workshop, July, 2001.

166. Chhieng DC, Rodriguez-Burford C, Sviglin H, Talley LI, Stockard CR, Kleinberg MJ,

Barnes MN, Partridge EE and Grizzle WE. Expression of CEA, Tag-72, and Lewis Y

antigen in primary and metastatic lesions of ovarian carcinoma. 93rd

Annual Meeting of

the American Association of Cancer Research, San Francisco, California April 6-10,

2002.

167. Frost AR, Talley LI, Chhieng D, Bell WC, Moore C, Grizzle WE. Ethnic differences in

expression of molecular markers in invasive breast carcinomas. 93rd

Annual Meeting of

the American Association for Cancer Research, San Francisco, CA, April 6 - 10, 2002

and the InterSPORE Scientific Meeting, July, 2002.

168. Barnes MN, Berry WD, Straughn JM, Kirby TO, Leath CA, Huh WK, Grizzle WE,

Edward PE. Utilization of a novel avian model of spontaneous ovarian carcinogenesis:

results of a controlled trial of hormonal based chemoprevention. American Society of

Clinical Oncology Annual Meeting, Orlando, FL, May 2002.

169. Chhieng DC, Rodriguez-Burford C, Stockard CR, Barnes MN, Sviglin H, Talley L,

Alvarez RD, Partridge EE, Grizzle WE. Expression of therapeutic targets in primary

matched metastatic lesions of ovarian carcinoma. 10th

SPORE Investigators’ Workshop,

Chantilly, Virginia, July 13-16, 2002. (Abstract #202).

170. Sadlonova A, Morphy LR, Moore C. Grizzle WE, Frost AR, Stromal and Epithelial

Interactions in Pre-Neoplastic Breast Disease Are Affected by Growth Factors. 10th

SPORE Investigators’ Workshop, Chantilly, Virginia, July 13-16, 2002.

171. Sadlonova A, Murphy L, Grizzle WE, Frost AR. The effect of growth factors on stromal

and epithelial interactions in pre-neoplastic breast disease. 93rd

Annual Meeting of the

American Association for Cancer Research, San Francisco, CA, April 6 - 10, 2002 and

the InterSPORE Scientific Meeting, July, 2002, (Abstract #52).


172. Chhieng DC, Frost AR, Niwas S, Weiss H, Grizzle W, Beeken S. Intratumoral

Heterogeneity of Biomarker Expression in Breast Carcinomas. Abstract presented at 91st

USCAP meeting at Chicago Feb 2003.

173. Steinhauer JR, Manne U, Jhala N, Grizzle WE. Heterogeneity of differentiation in

colorectal adenocarcinomas. Annual meeting of the United States and Canadian Academy

of Pathology, 2002.

174. Manne U, Hardin M, Sprague A, Jones WT, Grizzle WE. Validation of prognostic value

of molecular markers of colorectal Adenocarcinoma (CRC) using data mining tools. Fifth

Steering Committee Meeting of Early Detection Research Network of NCI-NIH, Houston

TX, Feb 3-5, 2002.

175. Manne U, Bell W, Jones J, Talley L, Said-Al-Naief N, Grizzle WE. Expression of TGF-

a, EGF receptor, erbB-2 and erbB-3 in squamous cell dysplasia and carcinoma of the

tongue. Amer Assoc Cancer Res Annual Meeting, 2002; Vol. 42, Abstract # 5018.

176. Manne U, Gary B, Jones, J, Jhala N, Chatla C, Grizzle WE. Differences in the

mutational spectra of the p53 gene in colorectal adenocarcinomas of African-Americans

and Caucasians. Amer Assoc Cancer Res Annual Meeting, 2002; Vol. 42, Abstract #

5018.

177. Nirag C Jhala, Manne U, Jones J, Oelschlager DK, Vasudevan V, Weiss HL, Grizzle

WE. Prognostic significance of p27kip-1 expression in colorectal adenocarcinomas is

associated with tumor stage. Amer Assoc Cancer Res Annual Meeting, 2002; Vol. 42,

Abstract # 1083.

178. Manne U, Jhala N, Vasudevan V, Jones JL, Weiss HL, Grizzle WE. Molecular changes in

adenomatous colorectal lesions in patients with existing colorectal Adenocarcinoma.

AACR, Frontiers in Cancer Prevention Research, Boston, MA October 14-18, 2002;

Abstract # B322.

179. Chhieng DC, Benson E, Eltoum IA, Eloubeidi MA, Jhala NC, Jhala D, Siegal GP,

Grizzle WE, Manne U. MUC1 expression in diagnosing pancreatic ductal carcinoma

obtained by fine needle aspiration biopsy. USCAP 2003.

180. Drake RR, Manne U, Adam BL, Ahn C, Cazares L, Semmes OJ, Bigbee WL, Grizzle

WE, Johnson DA, Seldi-tof-ms profiling of serum for early detection of colorectal

cancer. AACR 2003.

181. Carpenter M, Meleth S, Grizzle WE. Statistical processing and analysis of proteomic

and genomic data. Proceedings of the Pharmaceutical SAS Users Group (PharmaSUG),

April 2003, pp 545-548.

182. Chhieng DC, Miller E, Eltoum IA, Zhu L, Grizzle WE. Protein Profile of Body Cavity

Fluid by Surface Enhanced Laser Desorption/Ionization Time of Flight Mass

Spectrometry (SELDI-TOF). Mod Pathol. 2003; 16:62A.

183. Jones J, Rodriguez-Burford C, Zhou T, Tousson A, Grizzle WE. Phenotypic expression

of the TRAIL receptors, DR4 and DR5, in cell lines and tissues of adenocarcinomas of


the ovary. Presented at the 11th

SPORE Investigators’ Workshop, July 8-10, 2003,

Baltimore, MD.

184. Miller EJ, Suarez-Cuervo C, Singh RS, Vital-Reyes V, Barnes III, MN, Grizzle WE.

Effects of celebrex in ovarian carcinoma cell lines. Presented at the 11th

SPORE

Investigators’ Workshop, July 8-10, 2003, Baltimore, MD.

185. Jones J, Rodriguez-Burford C, Zhou T, Tousson A, LoBuglio AF, Buchsbaum DJ,

Grizzle WE. The phenotypic expression of TNF-related apoptosis-inducing ligand

(TRAIL) receptors, DR4 and DR5, in neoplasia of the breast. Presented at the 11th

SPORE Investigators’ Workshop, July 8-10, 2003, Baltimore, MD.

186. Barnes NM, Chieng D, Miller E, Grizzle WE, Jones L, Partridge EE. A controlled

clinical trial of celecoxib as a chemopreventive agent in women at elevated risk of

ovarian carcinoma: Evaluation of enrollment into a pilot study. Presented at the 11th

SPORE Investigators’ Workshop, July 8-10, 2003, Baltimore, MD.

187. Qu Z, Van Ginkel S., Thottassery JV, Nasrin M, Maxuitenki Y, Carey D, Frost AR,

Grizzle WE, Kern FG. Doxycycline-regulated expression of VEGF-A165 in MCF-7

breast cancer cells demonstrates its ability to enhance estrogen-stimulated tumor growth,

tamoxifen resistance and macrometastatic potential. Presented at the American

Association for Cancer Research 94th

Annual Meeting, July 2003, Washington, DC.

Abstract #4972.

188. Thottassery, Selander, Westbrook, Van Ginkel, Ross L, Frost, Maxuitenko, Grizzle,

White L, Kern. Effects of heparanase overexpression in MCF-7 cells transfected with

heparin-binding angiogenic factor FGF-1 in experimental metastasis assays. Presented at

the American Association for Cancer Research 94th

Annual Meeting, July 2003,

Washington, DC. Abstract #287.

189. Jones J, Zhou T, Tousson A, Rodriguez-Burford C, Grizzle WE. The pattern of

expression of TRAIL receptors, DR4 and DR5, in ovarian neoplasia. Presented at the

American Association for Cancer Research 94th

Annual Meeting, July 2003, Washington,

DC. Abstract #2185.

190. Manne U, Jhala N, Vasudevan V, Chatla C, Jones J, Suarez-Cuervo C, Meleth S, Grizzle

WE. Molecular phenotypic changes in adenomatous components of colorectal

adenocarcinomas. Presented at the American Association for Cancer Research 94th

Annual Meeting, July 2003, Washington, DC. Abstract #1877.

191. Sadlonova A, Moore CS, Grizzle WE, Frost AR. The effect of human mammary

fibroblasts on the progression of the MCF10AT xenograft model of proliferative breast

disease. Presented at the American Association for Cancer Research 94th

Annual

Meeting, July 2003, Washington, DC. Abstract #3434.

192. Gaines J, Bhoola SM, Straughn JM, Grizzle W, Strong TV, Shaw DR. Expression of

sperm protein 17 (Sp17) in ovarian tumors. Presented at the American Association for

Cancer Research 94th



193. Miller, EJ, Greene P, Chhieng D, Partridge E, Grizzle WE, Eltoum IA. SELDI-TOF

protein profiles of cervical mucus in normal vs. dysoplastic epithelium. Presented at the


Annual Meeting, July 2003, Washington,

DC. Abstract #486.

194. Fabian CJ, Clark J, Metheny T, Xue Q, Grizzle WE, Zalles CM Kimler BF. Proportion

of benign ductal epithelial cells expressing Ki-67/MIB-1 in random periareolar fine

needle aspirates from women at high risk for breast cancer. Presented at the American


Annual Meeting, July, 2003, Washington, DC.

Abstract #1878.

195. Singh S, Hannah PS, Singh UP, Grizzle WE, Lillard JW Jr. Differential CXCR4 and

CCR9 expression by prostate cancer. Presented at the American Association for Cancer

Research 94th


196. Ponnazhagan S, Mahendra G, Kumar S, Shaw DR, Stockard CR, Grizzle WE. Adeno-

associated virus-2-mediated anti-angiogenic gene therapy: Long-term efficacy of a

combination vector over individual therapy. Presented at the American Association for



197. Jhala N, Manne U, Chatla C, Meleth S, Jones J, Grizzle WE. Molecular phenotypic

expression in adenomas and colorectal adenocarcinomas. Gordon Research Conference

“New Frontiers in Cancer Detection & Diagnosis” meeting, August 17-22, 2003,

Andover, NH.

198. McDuffee E, Thornthwaite JT, Bates J, Stockard CR, Grizzle W. Immunostaining of a

newly identified cancer antigen present in cell membranes of ovarian carcinoma tissues.

Presented at the AACR “Frontiers in Cancer Prevention Research” meeting, October 26-

30, 2003, Phoenix, AZ.

199. Vital-Reyes V, Miller EJ, Rodriguez-Burford C, Suarez-Cuervo C, Singh RS, Barnes

MN, Grizzle WE. Effects of celebrex on ovarian carcinoma cell lines. Presented at the

AACR “Frontiers in Cancer Prevention Research” meeting, October 26-30, 2003,

Phoenix, AZ.

200. Grizzle WE, Manne U, Jhala N, Suarez-Cuervo C, Meleth S, Alexander D. (invited

presentation) The molecular staging of colorectal cancer. Presented at the Society of

Toxicology Meeting, March 21-25, 2004, Baltimore, MD.

201. Thomas RD, Grizzle WE, Manne U, McLean VA. Predicting clinical prognosis in

colorectal cancer patients using molecular profile data and bioinformatics technologies.

Presented at the Society of Toxicology Meeting, March 21-25, 2004, Baltimore, MD.

202. Rodriguez-Burford C, Chhieng DC, Talley L, Jones J, Grizzle WE, Ferguson SM.

Correlation of biomarker expression and response to preoperative chemotherapy in

patients with locally advanced breast cancer. Abstract #5255. Presented at the American


Annual Meeting, Orlando, Florida, March 27-31,

2004.


203. Chhieng DC, Meleth S, Miller E, Eltoum I, Zhu L, Grizzle WE. Protein profiles of body

cavity fluid generated by surface enhanced laser desorption/ionization time of flight mass

spectrometry (SELDI-TOF-MS) is helpful in distinguishing between reactive and

neoplastic processes. Abstract #3550. Presented at the American Association for Cancer

Research 95th

Annual Meeting, Orlando, Florida, March 27-31, 2004.

204. McDuffee EC, Thornthwaite JT, Jones JL, Rodriguez-Burford C., Grizzle WE. The

expression of LT-11 in ovarian carcinoma and normal ovarian tissues. Abstract #5471.

Presented at the American Association for Cancer Research 95th

Annual Meeting,

Orlando, Florida, March 27-31, 2004.

205. Bumpers HL, Huang MB, Grizzle WE, Okoli J, Powell M, Lillard J, Bond VC.

Antiangiogenic effects of a novel HIV nef cytotoxic peptide on the growth of primary

and metastatic colorectal cancer. Abstract #52. Presented at the American Association

for Cancer Research 95th


206. Suarez-Cuervo C, Herring C, Jhala N, Posey J, Grizzle W, Meleth S, Manne U.

Predictive value of molecular markers in clinical response of colorectal carcinoma to 5-

FU treatment. Abstract #1145. Presented at the American Association for Cancer

Research 95th


207. Gandham M, Katkoori VR, Soong R, Diasio RB, Suarez-Cuervo C, Meleth S, Shibata

DK, Grizzle WE, Manne U. Analysis of microsatellite instability in colorectal

adenocarcinomas of African-American and Caucasian patients. Abstract #918.

Presented at the American Association for Cancer Research 95th

Annual Meeting,


208. Jhala DN, Jhala NC, Jones JL, Grizzle WE. Clusterin expression in normal and

neoplastic islet cells of the pancreas. Abstract #1954. Presented at the American



2004.

209. Singh S, Singh UP, Grizzle WE, Lillard JW Jr. Cxcr5-mediated prostate cancer cell

migration and invasion. Abstract #1763. Presented at the American Association for



210. Singh S, Bond VC, Singh UP, Powell M, Grizzle WE, Bumpers HL, Lillard JW Jr.

Glycoprotein 120 IIIB mediates prostate cancer cell death and inhibits

lymphangiogenesis. Abstract #3794. Presented at the American Association for Cancer

Research 95th


211. Katkoori VR, Gandham M, Jhala NC, Soong R, Diasio RB, Meleth S, Grizzle WE,

Manne U. Differences in the mutational spectra of the p53 gene in proximal colonic

adenocarcinomas of African-American Caucasians. Abstract #4023. Presented at the


Annual Meeting, Orlando, Florida,

March 27-31, 2004.

212. Vital-Reyes V, Rodriguez-Burford C, Oelschlager DK, Suarez-Cuervo C, Manne U,

Grizzle WE. COX-2 inhibitor (Celecoxib) affects the cellular growth and phenotypic

expression of p53 in only selected colon, prostate and ovarian cancer cell lines. Abstract


#4391. Presented at the American Association for Cancer Research 95th

Annual Meeting,


213. Chatla C, Alexander D, Katholi CR, Jhala NC, Grizzle WE, Manne U. Bcl-2 expression

and p53 nuclear accumulation are the indicators of tumor recurrence and patient survival

in colorectal adenocarcinoma. Abstract #LB-213. Presented at the American



2004.

214. Pandya AY, Talley LI, Frost AR, Fitzgerald TJ, Trivedi V, Chakravarthy M, Chhieng

DC, Grizzle WE, Engler JA, Krontiras H, Bland KI, LoBuglio AF, Lobo-Ruppert SM,

Ruppert JM. Nuclear localization of KLF4 is associated with an aggressive phenotype in

early stage breast cancer. Presented at the 12th

SPORE Investigators’ Workshop,

Baltimore, MD, July 10-13, 2004.

215. Vital-Reyes V, Rodriguez-Burford C, Oelschlager DK, Suarez-Cuervo C, Manne U,

Grizzle, WE. The COX-2 inhibitor, Celecoxib, inhibits differentially the cellular growth

of ovarian, prostate and colon carcinoma cell lines independent of p53 status. Presented

at the 12th

SPORE Investigators’ Workshop, Baltimore, MD, July 10-13, 2004.

216. Barnes MN, Chhieng D, Jones J, Riaz V, Dreher M, Grizzle WE, Jones L, Talley L,

Partridge EE. A controlled clinical trial of Celecoxib as a chemopreventive agent for

ovarian cancer: a feasibility study in women at elevated risk. Presented at the 12th

SPORE Investigators’ Workshop, Baltimore, MD, July 10-13, 2004.

217. Vital-Reyes V, Rodriguez-Burford, Oelschlager KD, Suarez-Cuervo C, Manne U,

Grizzle WE. The COX-2 inhibitor, celecoxib, inhibits differentially the cellular growth

of ovarian, prostate and colon carcinoma cell lines independent of p53 status. Abstract #

508. Presented at the Third Annual AACR International Conference “Frontiers in Cancer

Prevention Research” meeting, Seattle, WA, October 16-20, 2004.

218. Manne U, Grizzle WE, Jhala N, Sreelatha M, Chatla C, Hardin M. Clinical implications of

molecular markers of colorectal cancer differ with tumor location, stage and ethnicity.

9th World Congress on Advances in Oncology and 7th International Symposium on

Molecular Medicine, Crete, Greece, 2004, Abstract 414.

219. Jhala N, Chatla C, Katkoori V, Herring C, Grizzle WE, Manne U. Usefulness of

molecular phenotypic expression in colorectal adenocarcinomas based on tumor stage,

differentiation and histologic type. Presented at the 2005 America Society of Clinical

Oncology Gastrointestinal Cancers Symposium, Miami, FL, January 27-29, 2005.

220. Semmes OJ, Malik G, Ward M, Trossett M, Grizzle W, Diaz J, Davis J, Schellhammer

P. Serum levels of an isoforms of apolipoprotein A-II as a potential marker for prostate

cancer. Presented at the 2005 American Society of Clinical Oncology Prostate Cancer

Symposium, Orlando, FL, February 17-19, 2005.

221. Vital-Reyes VS, Rodriguez-Burford C, Oelschlager DK, Grizzle WE. Albumin

influences the inhibitory effect exerted by celecoxib on cellular viability in WiDR and

CAOV3 cancer cell lines. (Abstract # 6083). Presented at the 2005 American

Association for Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.


222. Mittal A, Maxuitenko Y, Rinehart J, Waud WR, Thottassery J, Frost AR, Grizzle WE,

Rongbao L, Qu Z. A preclinical study of tamoxifen in combination with bevacizumab

(Avastin) for the treatment of ER-positive breast cancer. (Abstract #1091). Presented at

the 2005 American Association for Cancer Research Meeting, Anaheim, CA, April 16-

20, 2005.

223. Chatla C, Neelagiri V, Jain V, Jhala NC, Grizzle WE, Manne U. African-American

patients with high grade proximal colonic adenocarcinomas are at increased risk of short

survival. (Abstract #474). Presented at the 2005 American Association for Cancer

Research Meeting, Anaheim, CA, April 16-20, 2005.

224. Herring CB, Chatla C, Katkoori VR, Jhala NC, Oelschlager D, Grizzle WE, Manne U.

Detection of p53 mutations by a panel of monoclonal antibodies and their clinical

implications in colorectal adenocarcinoma. (Abstract #1262). Presented at the 2005

American Association for Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.

225. Benavides MA, Stockard CR, Oeslchlager DK, Vital-Reyes VS, Katkoori VR, Manne U,

Grizzle WE. Methionine inhibits the growth of MCF-7 (breast) and LNCaP (prostate)

cancer cell line but not DU-145 prostate cancer cell. (Abstract #1577). Presented at the

2005 American Association for Cancer Research Meeting, Anaheim, CA, April 16-20,

2005.

226. Rodriguez-Burford C, Chhieng DC, Jones JL, Meleth S, Grizzle WE, Ferguson SM.

Can biomarker expression be used as an indicator of response to preoperative

chemotherapy in patients with breast cancer? (Abstract #2174). Presented at the 2005

American Association for Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.

227. Jhala DN, Jhala NC, Jones J, Grizzle WE. Clusterin and Survivin in normal islets and

islet cell tumors of pancreas. (Abstract #2147). Presented at the 2005 American

Association for Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.

228. Singh S, Johnson EE, Singh UP, Cooper CR, Chung LWK, Datta MW, Grizzle WE,

Lillard JW Jr. CXCL13 bone marrow and CXCR5 prostate cancer cell expression and

functional roles in motility, adhesion and invasion. (Abstract #2383). Presented at the


2005.

229. Katkoori VR, Chatla C, Jia X, Grizzle WE, Manne U. Mutations in the L3 loop of zink-

binding domain of p53 are poor prognostic indicators of Caucasians with colorectal

adenocarcinomas. (Abstract #2548). Presented at the 2005 American Association for

Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.

230. Jhala NC, Grizzle WE, Vickers S, Jhala D, Arnoletti P, Saif MW, Russo S. Frequency

and association of downstream mediators of EGFr phosphorylation pathway in pancreatic

adenocarcinoma. (Abstract #2726). Presented at the 2005 American Association for

Cancer Research Meeting, Anaheim, CA, April 16-20, 2005.

231. Davila M, Grizzle WE, Chakrabarti R. Profiling of transcription factor activation by

androgen receptor in androgen dependent and androgen independent xenograft prostate


tumors. (Abstract #4517). Presented at the 2005 American Association for Cancer

Research Meeting, Anaheim, CA, April 16-20, 2005.

232. Piyathilake CJ, Owlschlager DK, Meleth S, Partridge EE, Grizzle WE. Potential use of

plasma protein profiles to identify high-grade cervical neoplasia among women positive

for high-risk (HR) human papilloma virus (HPV). (Abstract #4804). Presented at the


2005.

233. Ploeger LS, Van der Gusten J, Van der Giezen D, Belien J, Abbaker A, Dullens H,

Huisman A, Grizzle W, Poulin N, Van Diest PJ. Implementation of routine conflocal

DNA cytometry of clinical samples in 3D. Presented at Society for Cellular Oncology

meeting, Belfast. Cell Oncol 2005; 27:152.

234. Ploeger LS, Belien J, Poulin N, Grizzle W, Van Diest PJ. Confocal 3D cytometry:

assessment of required sample size by computer simulation. Presented at Society for

Cellular Oncology meeting, Belfast. Cell Oncol 2005; 27:152.

235. Huisman A, Ploeger LS, Dullens HFL, Lammers H, Jonges GN, Poulin NM, Grizzle W,

Van Diest PJ. 3-D chromatin texture analysis of prostate tissue using confocal laser

scanning microscopy. Presented at Society for Cellular Oncology meeting, Belfast. Cell

Oncol 2005; 27:157.

236. Steg A, Johnson M, Wang W, Grizzle WE. The use of paraffin embedded tissue in

analyses using real time quantitative PCR. Presented at the Early Detection Research

Network (EDRN) 4th

Annual Scientific Workshop, Philadelphia, PA, March 20-22, 2006.

237. Manne U and Grizzle WE. Comparison of prognostic value of molecular markers of

colorectal cancer predicted by proportional hazards regression and linear discriminant

analyses. Presented at the Early Detection Research Network (EDRN) 4th

Annual

Scientific Workshop, Philadelphia, PA, March 20-22, 2006.

238. Meleth S, Grizzle WE, Manne U. Comparison of prognostic value of molecular markers

of colorectal cancer predicted by proportional hazards regression and linear discriminant

analyses. Presented at the Early Detection Research Network (EDRN) 4th

Annual

Scientific Workshop, Philadelphia, PA, March 20-22, 2006.

239. Katkoori VR, Jia X, Chen DT, Grizzle WE, Manne U. Differential gene expression

profiles of colorectal adenocarcinomas in relation to a single nucleotide polymorphism at

-25 of the 5’ untranslated region (5’UTR-25) of the RPH3AL gene. (Abstract #96)

Presented at the 97th

American Association for Cancer Research (AACR) Annual

Meeting, Washington, DC, April 1-5, 2006.

240. Goli RR, Katkoori VR, Callens T, Messiaen L, Jhala NC, Grizzle WE, Manne U.

Higher incidence of single nucleotide polymorphisms at codon 72 of the p53 gene are

associated with poor prognosis of African-American patients with high grade colorectal

adenocarcinomas. (Abstract #391) Presented at the 97th

American Association for

Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.

241. Singh S, Singh R, Singh UP, Kimbro SK, Cooper CR, Chung LWK, Datta MW, Didier


PJ, Grizzle WE, Lillard JW. CXCR5-CXCL13 expression regulates cellular

mechanisms involved in prostate cancer cell invasion and correlates with prostate cancer

progression. (Abstract #289) Presented at the 97th

American Association for Cancer

Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.

242. Jia X, Katkoori VR, Jhala NC, Callens T, Messiaen L, Herring CB, Posey J, Grizzle WE,

Manne U. Molecular and immunohistochemical analysis of Smad4 in colorectal

adenocarcinomas. (Abstract #912). Presented at the 97th

American Association for

Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006.

243. McDuffee EC, Grizzle WE, Jones JL, Secor McVoy JR, Harris RB, Thornthwaite JT.

Characterization and phenotypic expression of carboxy-terminal cytokeratin 8 in normal

and malignant tissues producing a unique IgM response. (Abstract #2224) Presented at

the 97th

American Association for Cancer Research (AACR) Annual Meeting,

Washington, DC, April 1-5, 2006.

244. Singh S, Sinch R, Singh UP, Kimbro SK, Cooper CR, Chung LWK, Datta MW, Didier

PJ, Grizzle WE, Lillard JW. CC chemokine receptor-9 and its natural ligand CCL25,

regulates cellular mechanisms involved in prostate cancer progression. (Abstract #2464)


American Association for Cancer Research (AACR) Annual


245. Katkoori VR, Jia X, Chakrapani C, Kumar S, Selvarangan P, Grizzle WE, Manne U. A

novel single nucleotide polymorphism in the 5’ untranslated region of the Rabphillin-3A-

Like gene is associated with nodal metastasis, early recurrence and poor survival of

patients with colorectal adenocarcinoma. (Abstract #5728) Presented at the 97th

American Association for Cancer Research (AACR) Annual Meeting, Washington, DC,

April 1-5, 2006.

246. Benavides MA, Oelschlager DK, Zhang HG, Stockard CR, Vital-Reyes VS, Katkoori

VR, Manne U, Bland KI, Grizzle WE. Mehionine inhibits cellular growth dependent

upon the p53 status of cells. (Abstract #2639). Presented at the 97th

American

Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5,

2006.

247. Manne U, Suarez-Cuervo C, Jhala NC, Posey J, Herring CB, Meleth S, Grizzle WE.

Phenotypic expression of Bax is a predictive marker of 5-fluorouracil treatment in

colorectal cancer. (Abstract # 3605). Presented at the 2006 Annual Meeting of the

American Society of Clinical Oncology, Atlanta, GA, June 2-6, 2006.

248. McDuffee EC, Grizzle WE, Jones J, Secor McVoy JR, Harris RB, Thornthwaite JT. A

carboxy-terminal cytoketatin 8-like protein that produces a unique stable IgM response.


SPORE Investigator’s Workshop, Baltimore, MD, July 16-19, 2006.

249. Steg A, Johnson M, Wang W, Grizzle WE. Paraffin embedded tissues can be used in the

analyses of gene expression using real time quantitative PCR. Presented at the 14th

SPORE Investigator’s Workshop, Baltimore, MD, July 16-19, 2006.

250. Otali D, Stockard CR, Oelschlager D, Grizzle WE. Loss of epitope immunorecognition:

combined effects of fixation and dehydration and the extent of recovery of epitope


recognition by antigen retrieval. Presented at the Gordon Research Conference “New

Frontiers in Cancer Detection & Diagnosis” workshop, Ventura, CA, January 21-26,

2007.

251. Phillips PA, Dudeja V, Dawra R, Grizzle WE, Vickers S, Saluja A. Triptolide decreases

pancreatic cancer growth and metastases by inhibiting HSP70 expression: A potential

therapeutic candidate. Presented at the American Association for Cancer Research

(AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract # 5626).

252. Herbey I, Ivankova NV, Grizzle WE. Cancer development trends in Eastern European

countries and USA: A comparative study. Presented at the American Association for

Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007.

(Abstract #64).

253. Singh R, Lillard Jr JW, Grizzle WE, Singh S. CCR9-CCL25 interaction involved in

prostate cancer cell survival. Presented at the American Association for Cancer Research

(AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract # 458).

254. Jia X, Katkoori VR, Callens T, Shanmugam CK, Jhala NC, Messiaen L, Grizzle WE,

Manne U. Immunohistochemical staining patterns of Smad4 expression based on 18q

deletions in colorectal adenocarcinomas. Presented at the American Association for


(Abstract # 205).

255. Katkoori V, Goli RR, Callens T, Messiaen L, Jhala NC, Grizzle WE, Meleth S, Manne

U. Prognostic value of molecular alterations in high grade colorectal adenocarcinomas

varies in African-Americans and Caucasians. Presented at the American Association for


(Abstract # 141).

256. Uruno T, Cruz-Montero C, Fridlyand J, Chew K, Grizzle W, Gray JW, Chin K.

Assessment of genome aberrations of ~ 120 breast cancers in African American women.

Presented at the American Association for Cancer Research (AACR) Annual Meeting,

Los Angeles, CA, April 14-18, 2007. (Abstract # 2940).

257. Katkoori VR, Jia X, Callens T, Kumar S, Ponnazhagan S, Messiaen L, Grizzle W,

Manne U. Rabphillin-3A-Like gene is a candidate tumor suppressor in colorectal

adenocarcinoma. Presented at the American Association for Cancer Research (AACR)

Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract # 3650).

258. Jia X, Katkoori VR, Callens T, Messiaen L, Grizzle WE, Siegal GP, Manne U.

Correlation between the abnormalities of p53 and Rabphillin-3A-Like genes in colorectal

adenocarcinoma. Presented at the American Association for Cancer Research (AACR)

Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract # 4555).

259. Shanmugam CK, Katkoori VR, Jia X, Jhala NC, Grizzle WE, Manne U. Allelic variants

of the Rabphillin-3A-Like gene and their association with aggressive phenotypic features

of colorectal adenocarcinomas. Presented at the American Association for Cancer

Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract #

5306).


260. Chakrabarti R, Jones JL, Oelschlager DK, Tapia T, Tousson A, Grizzle WE.

Phosphorylated LIM kinases colocalize with gamma-tubulin in centrosomes during early

stages of mitosis. Presented at the American Association for Cancer Research (AACR)

Annual Meeting, Los Angeles, CA, April 14-18, 2007. (Abstract # LB228).

261. Grizzle WE and Sexton KC. Establishing a tissue resource/repository”. Presented at the

ISBER 2007 Annual Meeting, Singapore, May 30 – June 2, 2007.

262. Reddy VB, Oelschlager DK, Nolan JS, Taylor KL, Post J, Grizzle WE, Manne U.

Cytokin expression profiles of patients with acute myelogenous leukemia (AML) and

non-hodgkin lymphoma (NHL) detected by Luminex-based multiplex assay. Presented

at the ASCO Annual Meeting, Chicago, Illinois, June 1-5, 2007.

263. Steg A, Vickrs SM, Eloubeidi M, Wang W, Eltoum IA, Grizzle WE, Frost AR, Johnson

MR. Quantifying gene expression in heterogeneous pancreatic adenocarcinoma:

Implications for the molecular analysis of clinically available biopsies. Presented at the

158th

SPORE Investigators Workshop, Baltimore MD, July 7-10, 2007.

264. Manne U, Grizzle WE, Alexander DD, Katkoori V. Racial differences in colorectal

cancer: the need to educate clinicians and researchers for improved patient care. To Be

Presented at the American Association for Cancer Education annual meeting,

Birmingham, AL, October 11-13, 2007.

265. Talley LI, Stockard CR, Otali D, Chandrakumar S, Steciuk MR, Parker SB, Adams AL,

Chhieng CF, Hameed O, Johnson MR, Grizzle WE, Frost AR. Racial differences in

ductal carcinomas of the breast and DCIS. Presented at the AACR Science of Cancer

Health Disparities Meeting, Atlanta GA, November 27-30, 2007. (Abstract #A74).

266. Katkoori VR, Jia X, Callens T, Messiaen L, Shanmugam CK, Grizzle WE, Manne U.

Prognostic importance of p53 codon 72 polymorphism differs with race in microsatellite

stable colorectal adenocarcinoma. Presented at the AACR Science of Cancer Health

Disparities Meeting, Atlanta GA, November 27-30, 2007. (Abstract #A26).

267. Katkoori VR, Jia X, Callens T, Messiaen L, Shanmugam K, Grizzle WE, Manne U.

Prognostic importance of p53 codon 72 polymorphism differs with race in microsatelitte

stable colorectal adenocarcinoma. Presented at the AACR Science of Cancer Health

Disparities Meeting, Atlanta GA, November 27-30, 2007. (Abstract #PR-11).

268. Jia X, Shanmugam S, Katkoori VR, Jhala NC, Callens T, Messiaen L, Grizzle WE,

Manne U. Loss of heterozygosity at 17p13 and 17p13.1 loci is associated with poor

survival of African Americans with colorectal adenocarcinomas. Presented at the AACR

Science of Cancer Health Disparities Meeting, Atlanta GA, November 27-30, 2007.

(Abstract #B101).

269. Kim H., Morgan DE., Buchsbaum D. J., Zeng H., Grizzle WE., Warram JM., Stockard

CR., McNally LR., Long JW., Sellers JC., Forero A., Zinn KR., "Early evaluation of a

novel therapy with anti-DR5 antibody and chemotherapy in orthotopic pancreatic tumor

xenografts using high field strength diffusion weighted imaging." Proceedings of

American Association for Cancer Research Annual Meeting, vol. 49, pp 881, 2008.


270. Katkoori VR, Xu J, Shanmugam C, Ponnazhagan S, Lin H-Y, Grizzle WE, Manne U.

Down regulation of the Rabphillin-3A-Like gene, located on 17p 13.3, is associated with

the metastasis of colorectal adenocarcinoma. Abstract # 334. Proceedings of American

Association for Cancer Research Annual Meeting, San Diego, CA, April 14-16, 2008.

271. Shanmugam C, Jhala NC, Meleth S, Junker W, Batra SK, Grizzle WE, Manne U.

Aberrant phenotypic expression of MUC17 is associated with aggressive behavior of

colorectal adenocarcinomas. Abstract #987. Proceedings of American Association for

Cancer Research Annual Meeting 2008. Proceedings of American Association for Cancer

Research Annual Meeting, San Diego, CA, April 14-16, 2008.

272. Herbey I, Ivankova N, Grizzle WE, Waterbor J. Title: Nuclear radiation, age and cancer

incidences in Eastern European countries, 1983-1997. Abstract #1055. Proceedings of

American Association for Cancer Research Annual Meeting, San Diego, CA, April 14-

16, 2008.

273. Sharma PK, Singh R, Lilard JW, Chung LWK, Grizzle WE, Singh S.Title: CCR9-

mediated inhibition of drug-induced apoptosis in prostate cancer cells. Abstract #1333.

Proceedings of American Association for Cancer Research Annual Meeting, San Diego,

CA, April 14-16, 2008.

274. Kim H, Morgan DE, Buchsbaum DJ, Zeng H, Grizzle WE, Warram JM, Stockard CR,

McNally LR, Long JW, Sellers JC, Forero A, Zinn KR. Title: Early evaluation of a novel

therapy with anti-DR5 antibody and chemotherapy in orthotopic pancreatic tumor

xenografts using high field strength diffusion weighted imaging. Abstract #3722.

Proceedings of American Association for Cancer Research Annual Meeting, San Diego,

CA, April 14-16, 2008.

275. Suzuki J, Uruno T, Cruz-Montero C, Klein-McDowell M, Tokuyasu T, Roydasgupta R,

DeVries S, Waldman FM, Chew K, Grizzle WE, Gray JW, Chin K. Analysis of genomic

disparity in ~ 230 breast cancer between African American and white women.Abstract

#LB-280. Proceedings of American Association for Cancer Research Annual Meeting,

San Diego, CA, April 14-16, 2008.

276. Grizzle WE, Talley LI, Stockard CR, Steciuk MR, Otali D, Brown-McGauley C,

Shanmugam C, Parker SB, Adams, AL, Chhieng CF, Hameed O, Johnson MR, Manne U.

Racial differences in DCIS and carcinoma of the breast. Abstract #5485. Proceedings of

American Association for Cancer Research Annual Meeting, San Diego, CA, April 14-

16, 2008.

277. Kim HK, Martin CM, Andea AA, Grizzle WE, Katiyar SK, Elmets CR, Timares, L. Bid

cell cycle regulation isoform induction and tumor suppressor activity in UV-induced skin

carcinogenesis. DNA Repair and Genomic Stability: Implications for Cancer: 07-Jan-08

ENU DNA-1477. Houston Texas.

278. Hsu HC, Yang P, Wu Q, Stockard C, Job G, Grizzle WE, Mountz JD. Positive Feedback

of Autoantibodies, Immune Complexes, and Spontaneous Germinal Centers Through An

AID-Dependent Mechanism. Abstract #741. American College of Rheumatology, San

Francisco, CA, Oct 24-29, 2008.


279. Benavides MA, Hagen K, Fang W, Pigino G, Bongarzone E, Yang W, Bland KI, Grizzle

WE, Bosland, MC. Methionine induces cell cycle arrest selectively in LNCaP and MCF-

7 cells, but not in colon cancer cells or untransformed breast, prostate and colon cells.

Abstract #1276. American Association for Cancer Research annual meeting, Denver,

CO, April 19-22, 2009.

280. McNally LR, Stafford LJ, Welch DR, Long JW, Sellers JC, Huang ZQ, Grizzle WE,

Stockard CR, Buchsbaum DJ. KiSS 1 re-expression in pancreatic adenocarcinoma in a

xenograft mouse model. Abstract #1189. American Association for Cancer Research

annual meeting, Denver, CO, April 19-22, 2009.

281. Shanmugam C, Katkoori VR, Jhala NC, Wan W, Meleth S, Junker W, Batra SK, Grizzle

WE, Manne U. Increased expression of MUC4 is associated with poor survival of

patients with early stage colorectal adenocarcinomas. Abstract #2726. American

Association for Cancer Research annual meeting, Denver, CO, April 19-22, 2009.

282. Singh PK, Singh R, Eaton JW, Lilliard Jr JW, Novakovic KR, Grizzle WE, Chung

LWK, Singh S. Expression and functional role of CXCR6 in prostate cancer. Abstract

#2258. American Association for Cancer Research annual meeting, Denver, CO, April

19-22, 2009.

283. Grizzle WE, Talley LI, Stockard CR, Steciuk MR, Otali D, Shanmugam CK, Parker SB,

Chhieng CF, Hameed O, Johnson MR, Manne KB, Manne U, Meleth S, Frost AR.

Analysis by race of p53 and Bcl-2 interaction in DCIS. Abstract #3441. American

Association for Cancer Research annual meeting, Denver, CO, April 19-22, 2009.

284. Katkoori VR, Shanmugam C, Lucas BL, Batra SK, Grizzle WE, Siegal GP, Manne U.

MUC17 is a potential tumor suppressor gene in colorectal adenocarcinoma. Abstract

#4362. American Association for Cancer Research annual meeting, Denver, CO, April

19-22, 2009.

285. Sharma PK, Singh R, Eaton JW, Lilliard Jr. JW, Novakovic KR, Grizzle WE, Chung

LWK, Singh S. CCL25 blockage inhibits anti-apoptotic signals in prostate cancer cells

and enhances cytotoxic effects of etoposide. Abstract #4583. American Association for

Cancer Research annual meeting, Denver, CO, April 19-22, 2009.

286. Jia X, Shanmugam CK, Callen T, Messiaen L, Grizzle WE, Manne U. Molecular

analysis of the Rabphillin 3A-Like gene in breast normal and tumor cell lines and tissues.

Abstract #5328. American Association for Cancer Research annual meeting, Denver,

CO, April 19-22, 2009.

287. Kulcycki A, Grizzle WE, Meleth S, You Z, Oelschlager D. Proteomic analysis of

seminal and vaginal fluid for developing improved biomarkers in contraceptive research.

Population Association of America annual meeting, April 29-May 2, 2009.

288. Tuder RM, Sexton KC, Zhang L, Watkins J, Parker SB, Grizzle WE (2009, May).

Histopathological assessment of the first 9 cases collected by the Pulmonary

Hypertension Breakthrough Initiative (PHBI). Presented at the International Conference

of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179


April: A4881.

289. Kim H, Zinn KR, Folks KD, Guo L, Stockard CR, Fineberg N, Grizzle WE, George JF.

Novel MRI biomarkers measuring early response of breast tumor xenografts following

anti-DR5 and bevacizumab therapies. 2009 World Molecular Imaging Congress (WMIC

2009), September 23-26, 2009.

290. Jian B, Grizzle W, Bland K, Chaudry I, Raju R. Anosmin-1 is a hypoxia-inducible

neuroprotectant. Neurological Association and Society for Neuroscience 134th

Annual

Meeting, Baltimore, Maryland, October 11-14, 2009.

291. Shanmugam CK, Hines RB, Jhala NC, Grizzle WE, Manne U. Clinical significance of

lymph node extraction in Stage II and III colon cancers. UAB-CCC-Annual Retreat,

October-2009.

292. Bovell L, Katkoori VR, Shanmugam CK, Lee C-H, Sreelatha Meleth, Bumpers HL,

Grizzle WE, Manne U. The prognostic value of microRNAs in colorectal cancer varies

with patient race/ethnicity. UAB-CCC-Annual Retreat, October-2009.

293. Grizzle WE, Jhala NC, Eloubeidi MA, Christein JD, Arnoletti JP, Oelschlager DK,

Wang J, He Q, Vickers SM. Mulitplex immunoassays of cytokines in EUS-FNAs of the

Pancreas. Presented at the NCI Translational Sciences Meeting, Vienna, VA, November

5-7, 2009.

294. Frederick PJ, McNally LR, Bevis KS, Sellers JC, Manna DLD, Grizzle WE, Stockard

CR, Straughn Jr. JM, Buchsbaum DJ. The expression of lung resistance protein (LRP)

predicts platinum resistance in patients with advanced epithelial ovarian carcinoma.

Presented at the Society of Gynecologic Oncology, 2010 Annual Meeting on Women's

Cancer. San Francisco, California, March 14-17, 2010

295. Kerr EH, V Dailey V, Grizzle WE, Hameed O. Should Saved Interval Sections of

Prostate Needle Biopsy (PNBx) Specimens be Examined Microscopically? Presented at

the United States and Canadian Academy of Pathology, 2010 Annual Meeting,

Washington, DC, March 20-26, 2010

296. Kraemer MB, Idrees K, Wang D, Liles S, Heslin S, Chernock RD, Lewis JS, GrizzleWE

Hameed O. Growth Factor Receptor Expression and Microvascular Density in Adrenal

and Extra-Adrenal Pheochromocytomas/Paragangliomas (PG). Presented at the United

States and Canadian Academy of Pathology, 2010 Annual Meeting, Washington, DC,

March 20-26, 2010

297. Kim H, Zinn KR, Buchsbaum DJ, Guo L, Sellers JC, Fineberg N, Stockard CR, Grizzle

WE, George JF, Folks KD. Early therapy assessment of cetuximab and irinotecan in

orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic

resonance imaging. Abstract # 7355. Proceedings of the American Association for

Cancer Research. Presented at the AACR 101st Annual Meeting 2010, Washington, DC,

April 17-21, 2010.

298. Benavides MA, Hu D, Baraoidan MK, Bruno A, Du P, Lin S, Yang W, Bland KI,

Grizzle WE, Bosland MC. Identification of a Molecular Signature after of L-methionine


treatment in MCF-7 and LNCaP Cancer Cells. Presented at the AACR 101st Annual

Meeting 2010, Washington, DC, April 17-21, 2010.

299. Grizzle WE, Eloubeidi MA, Christein JD, Arnoletti JP, Vickers SM, Jhala NC.

Multiplex Immunoanalysis of Cytokines in EUS-FNAs and in Plasma to Detect

Pancreatic Cancer. Presented at the AACR 101st Annual Meeting 2010, Washington,

DC, April 17-21, 2010.

300. Nolen B, Lomakin A, Bast Jr R, Lu K, Grizzle WE, Jhala NC, Eloubeidi MA, Christein

JD, Arnoletti JP, Oelschlager DK, Vickers SM, Marrangoni A, Lokshin A. Urine

biomarkers outperform serum biomarkers in the diagnosis of various human cancers.

Presented at the AACR Annual Meeting, 2010.

301. Bovell L, Katkoori VR, Shanmugam C, Lee CH, Meleth S, Bumpers HL, Grizzle WE,

Manne U. Higher Expressions of miR-21, miR-106a, miR-181b, and miR-203 are

Associated with Poor Prognosis in Colorectal Cancer Patients. Presented at the AACR

Annual Meeting, 2010.

302. Atha DH, Tona A, Manne U, Grizzle WE, Wagner P, Srivastava S, Elliott JT.

Development of an In-Vitro System for Performance Characterization of p53 Antibodies.

Presented at the AACR Annual Meeting, 2010.

303. McNally LR, Frederick PJ, Bevis KS, Sellers JC, Della Manna DL, Straughn JM,

Stockard CR, Grizzle WE, Buchsbaum DJ. The expression of lung resistance protein

(LRP) in patient ascites predicts platinum resistance in advanced epithelial ovarian

carcinoma. Presented at the AACR Annual Meeting, 2010.

304. Sharma PK, Singh R, Grizzle WE, Singh S. Clinical and biological signaificance of

CCR9-CCL25 axis in prostate cancer. Presented at the AACR Annual Meeting, 2010.

305. Benavides MA, Hagen KL, Yang W, Grizzle WE, Bosland MC. Methionine modulates

p53 and induces cell cycle arrest G1 in breast and prostate cancer cell lines. Presented at

the AACR Annual Meeting, 2010.

306. Grizzle WE. The importance of tissue resources to research. Presented at the

Biopsecimen Shared Resource Lecture at the University of Kansas Cancer Center, April

26, 2010.

307. Kim H, Zinn KR, Buchsbaum DJ, Guo L, Sellers JC, Fineberg N, Stockard CR, Grizzle

WE, George JF, Folks KD. Dynamic Contrast-Enhanced Magnetic Resonance Imaging

for Early Therapy Evaluation of Combined Anti-EGFR Antibody and Irinotecan in

Orthotopic Pancreatic Tumor Xenografts. Abstract # 6384. Presented at the Proceeding

of International Society of Magnetic Resonance in Medicine. ISMRM-ESMRMB Joint

Annual Meeting, Stockholm, Sweden, May 3-7, 2010.

308. Barnes JA , Bradley WE, Stockard CR, Grizzle WE, Dell’Italia LJ, Glasgow JN, Curiel

DT, Preuss MA . Targeted treatment of pulmonary hypertension with adenovirus

expressing the endothelin B receptor. Presented at the ASGT 13th

Annual Meeting and

Clinical Trials Training Course, Washington DC, May 17-22, 2010.


309. Singh S, Grizzle WE. Significance of CCR9-CCL25 axis in prostate cancer metastasis.

Presented at theAmerican Urological Association Education and Research, Inc., 2010

Annual Meeting. San Francisco, CA, May 29 – June 3, 2010.

310. Grizzle WE, Talley LI, Stockard CR, Steciuk MR, Chandrakumar S, Parker SB, Hameed

O, Johnson MR, Manne KB, Manne U, Meleth S, Frost AR. Analysis by Race of p53

and Bcl-2 Interaction in DCIS. 2010 Breast SPORE Rountable Meeting, Nashville, TN,

May 20-22, 2010.

311. Grizzle WE. Factors that affect the quality and usefulness of tissues in biomedical

research. Presented at the 8th

Australasian Biospecimen Network Annual Meeting,

Brisbane, December 2, 2010.

312. Grizzle WE. Biobanking and tissue repositories. Presented at the 6th

Annual Academic

Surgical Congress, February 1, 2011.

313. Grizzle WE, Sexton KC, Henderson M, Sobel, Hewitt R, Jewell S. The facilitation of

communication among repositories by the International Society for Biological and

Environmental Repositories (ISBER). Presented at the 4th

Annual Biospecimen Research

Network (BRN) Symposium, Bethesda, MD, March 28-29, 2011.

314. Grizzle WE, Kerr EH, Parker SB, Oelschlager DK, McNally LR. Variability of

microRNA measurements in breast ductal carcinomas. Presented at the American

Association for Cancer Research 102nd

Annual Meeting, Orlando, Florida, April 2-6,

2011.

315. Srivastava SK, Singh S, Bhardwaj A, Grizzle WE, Singh AP. miR-345 is a novel tumor

suppressor microRNA in pancreatic cancer. Presented at the American Association for

Cancer Research 102nd

Annual Meeting, Orlando, Florida, April 2-6, 2011.

316. Kerr EH, Oelschlager DK, McNally LR, Grizzle WE. Interleukin 6 may predict

chemoresistant ovarian cancer. Presented at the American Association for Cancer

Research 102nd


317. Shah N, Zhai G, Knowles J, Stockard C, Grizzle W, Fineberg N, Zhou T, Zinn K,

Rosenthal E, Kim H. Therapy assessment of a novel anti-EMMPRIN antibody and

gemcitabine in an orthotopic pancreatic-tumor murine model by FDG PET/CT imaging.

Presented at the American Association for Cancer Research 102nd

Annual Meeting,

Orlando, Florida, April 2-6, 2011.

318. Kerr EH, Frederick PJ, Oelschlager DK, Amm H, Sellers J, Della Manna D, Buchsbaum

DJ, Buchsbaum DJ, Grizzle WE, McNally LR. Chemoresistance in patients with

papillary serous carcinoma of the ovary. Presented at the American Association for



319. Piazza GA, Keeton AB, Tinsley HN, Whitt JD, Li N, Gurpinar E, Sun Y, Matthew B,

Reynolds RC, Zhang W, Singh R, Coward L, Gorman G, Maxuitenko YY, Grizzle WE,

Chang WC, Clapper M. Colon cancer chemopreventive properties of a non-

cyclooxygenase inhibitory amide derivative of sulindac. Presented at the American




2011.

320. Bovell LC, Shanmugam C, Katkoori V, Salih C, Grizzle WE, Manne U. Fixation does

not affect the integrity of microRNAs in archival colorectal cancer specimens over a

period of 20 years. Presented at the American Association for Cancer Research 102nd


321. Shanmugam C, Salih C, Katkoori VR, Bovell LL, Callens T, Messiaen LM, Hameed O,

Grizzle WE, Manne U. Single nucleotide polymorphisms in p53 condon 72 is associated

with grade III tumors in African-Americans with breast carcinoma. Presented at the

American Association for Cancer Research 102nd


April 2-6, 2011.

322. Ahluwalla S, Shanmugam C, Katkoori VR, Jhala NC, Sugandha SP, Grizzle WE, Manne

U. The prognostic value of p53 abnormalities in colorectal cancers varies based on

detection methods. Presented at the American Association for Cancer Research 102nd


323. Katkoori VR, Salih C, Sthanam M, Shanmugam, Callens T, Messiaen LM, Grizzle WE,

Bumpers HL, Birdsong G, Manne U. Prognostic significance of the low level

microsatellite instability phenotype differs with race in colorectal adenocarcinoma.

Presented at the American Association for Cancer Research 102nd

Annual Meeting,

Orlando, Florida, April 2-6, 2011.

324. Srivastava SK, Bhardwaj A, Singh S, Reed E, Grizzle W, Singh AP. C-Myb promotes

growth, invasion and androgen-independence of prostate cancer cells. Presented at the



April 2-6, 2011.

325. Liu Y, Xiang X, Grizzle W, Miller D, Zhang HG. Contribution of MyD88 to the tumor

exosomes-mediated induction of myeloid derived suppressor cells. Presented at the



April 2-6, 2011.

326. Nolen BM, Lomakin A, Grizzle WE, Jhala N, Eloubeidi MA, Christein JD, Arnoletti JP,

Oelschalger DK, Vickers SM, Lokshin AE. The combined use of urine and serum

biomarkers in early detection strategies for pancreatic cancer. Presented at the American



2011.

327. Singh S, Srivastava SK, Bhardwaj A, Owen LB, Grizzle WE, Singh AP. Evidence

supporting a role of in pancreatic cancer. Presented at the American Association for



328. Sun D, Zhuang X, Grizzle W, Miller D, Zhang HG. A novel nanoparticle drug delivery

system: the anti-inflammatory activity of curcumin is enhanced whtn encapsulated in

exosomes. Presented at the American Association for Cancer Research 102nd

Annual

Meeting, Orlando, Florida, April 2-6, 2011.

329. Kim H, Zhai G, Shah N, Liu Z, Helman E, Knowles J, Stockard C, Grizzle W, Zhou T,


Zinn K, Rosenthal E. Novel monoclonal antibody targeting EMMPRIN for pancreatic

cancer therapy. Presented at the American Association for Cancer Research 102nd


330. Singh R, Singh S, Grizzle WE, Lillard Jr. JM. Expression and functional role of CXCR5

and CXCL13 in non-small cell lung carcinoma (NSCLC). Presented at the American



2011.

331. Singh R, Lillard Jr JW, Grizzle WE, Singh S. Expresson and functional role of CCR9 in

lung cancer. Presented at the American Association for Cancer Research 102nd

Annual

Meeting, Orlando, Florida, April 2-6, 2011.

332. Grizzle WE. Return of research results: stakeholder prospective and practical

implementation issues biobank perspective. Presented at the 2011 ISBER Meeting,

Arlington, VA, May 18, 2011.

333. Gaston SM, Kearney GP, Grizzle WE. Prostate biopsy tissue print technologies; a

practical and innovative approach to overcoming racial disparities in the datasets used for

prostate cancer biomarker development. Presented at the AACR Cancer Health

Disparities Meeting, Washington, D.C., September 18, 2011.

334. vonMenchhofen Z, Livolsi V, Grizzle W, Sexton K, McGarvey D. Controlled

vocabularies for Bio-repositories-an integrated, simplified approach: keeping its structure

simple (KISS). Presented at the Association of Pathology Informatics Conference,

Pittsburgh, PA, October 4-7, 2011.

335. Grizzle WE, Otali D, He Q, Stockard. Effects on immunorecognition of transfer of cells

from 10% NBF to 70% ethanol. Presented at the 5th


Network (BRN) Symposium. Bethesda, Maryland, February 22-23, 2012.

336. Kulesza P, Grizzle WE et. al. Comparison of FNA and core biopsy versus complete

excision in monitoring tumor response to EGFR blockade in murine xenograft models.

Presented at the United States and Canadian Academy of Pathology 101st Annual

Meeting, Vancouver, BC, Canada, March 17-23, 2012.

337. Nguyen TH, Berg PE, Ghimbovschi S, Grizzle WE. Differential expression of BP1 and

associated gene networks in breast cancer of African American women and Caucasian

American women. Presented at the AACR Annual Meeting, Chicago, IL, March 31 –

April 2, 2012.

338. Katkoori VR, Choudhary S, Butler AR, Shanmugam C, Bovell LL, Samuel T, Athar M,

Grizzle WE, Manne U. Interaction between the rabphillin-3A-like gene and

phosphorylation of mammalian target of rapamycin (mTOR) in colorectal cancer.

Presented at the AACR Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

339. Vaklavas C, Meng Z, White EL, Rasmussen L, Maddry JA, Nebane-Akah M, Grizzle

WE, Zinn KR, Frost AR, Stockard CR, Samuel SL, Everts M, Whitley RJ, Blume SW.

Blocking synthesis of oncogenic proteins in breast tumor cells through pharmacologic

inhibition of the IRES. Presented at the AACR Annual Meeting, Chicago, IL, March 31


– April 2, 2012.

340. Bhardwaj A, Srivastava SK, Singh S, Arora S, Honkanen RE, Grizzle WE, Reed E,

Singh AP. Protein phosphatase 2A (PP2A) downregulation is associated with androgen-

independent and aggressive phenotypes in prostate cancer. Presented at the AACR

Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

341. Tinsley HN, Gary BD, Whitt J, Zhang W, Chen X, Keeton AB, Grubbs CJ, Grizzle WE,

Piazza GA. Breast cancer chemopreventive activity of a novel amide derivative of

sulindac involves inhibition of PDE5, activation of PKG, and attenuation of Wnt/β-

catenin signaling. Presented at the AACR Annual Meeting, Chicago, IL, March 31 –

April 2, 2012.

342. Srivastava SK, Bhardwaj A, Arora S, Singh S, McClellan S, Wang B, Grizzle WE,

Singh AP. MiR-345 downregulation is assocatied with apoptosis resistance in pancreatic

cnacer: therapeutic implications. Presented at the AACR Annual Meeting, Chicago, IL,

March 31 – April 2, 2012.

343. Otali D, He Q, Stockard CR, Grizzle WE. Preservation of immunorecognition by the

transfer of cells from 10% neutral buffered formalin to 70% ethanol. Presented at the

AACR Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

344. Gurpinar E, Grizzle WE, Liu Y, Shacka JJ, Keeton AB, Piazza GA. A novel non-COX-

inhibitory sulindac derivative induces autophagic cell death in lung adenocarcinoma

cells. Presented at the AACR Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

345. Singh R, Grizzle WE, Singh S, Lillard Jr JW. Expression of CXCR5 and its natural

ligand CXCL13 in ovarian cancer. Presented at the AACR Annual Meeting, Chicago, IL,

March 31 – April 2, 2012.

346. Srivastava SK, Arora S, Bhardwaj A, Scammell JG, Owen LB, Grizzle WE, Singh AP,

Singh S. Evidence supporting a role of FKBP51 in melanoma pathogenesis. Presented at

the AACR Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

347. Singh R, Grizzle WE, Lillard Jr JW, Singh S. Withaferin-A inhibits prostate utmor

growth by enhancing anti-tumor immune response. Presented at the AACR Annual

Meeting, Chicago, IL, March 31 – April 2, 2012.

348. Ludwig MR, Kojima K, Grizzle WE, Mobley JA, Klug CA. Identification of pre-

invasive pancreatic cancer serum biomarkers using genetically engineered mouse modesl

and mass spectrometry techniques. Presented at the AACR Annual Meeting, Chicago,

IL, March 31 – April 2, 2012.

349. Green HN, Grizzle WE, Rosenthal EL, Mirov SB, McNally LR. Active targeting,

fluorescence imaging, and NIR photothermal therapy of malignant tumors. Presented at

the AACR Annual Meeting, Chicago, IL, March 31 – April 2, 2012.

350. McNally LR, Kerr EH, Oelschalger D, Grizzle WE. miRNA expression differes

between African American and European American patients with pancreatic

adenocarcinoma. Presented at the Sixth Annual Pancreatic Cancer Advocacy Day


meeting, Washington, DC, June 25-26, 2012.

351. Grizzle WE. Collecting Human and Animal Tissues to Support Biomedical Research:

Effects on the Operations of Anatomic Pathology. Presented at the National Society for

Histotechnology Annual Meeting, Vancouver, Canada, October 3, 2012.

352. Varley KT, Gertz J, Agee JM, Oliver PG, Buchsbaum DJ, Grizzle WE, LoBuglio AF,

Myers R. Integrated analysis of DNA methylation, RNA-seq and ChIP-seq to identify

master regulators of breast cancer subtype gene expression signatures. Presented at the

14th

Annual Advances in Genome Biology and Technology (AGBT) Meeting, Marco

Island, FL, February 20-23, 2013.

353. Li R, Nguyen T, Kragel C, Zhang K, Grizzle WE, Hameed O, Siegal GP, Wei S. The

RANK pathway in breast cancer: Src plays a role! Presented at the United States &

Canadian Academy of Pathology’s 102nd

Annual Meeting, Baltimore, MD, March 2-8,

2013.

354. Lubenski I, Grizzle WE, Watson M, Moskaluk C, Trock B, Mechanic L, Alvanja M, Zhu

C. Federally supported cancer biospecimen resources available to the research

community. Presented at the AACR 2013 Annual Meeting, Washington, DC, April 6-11,

2013.

355. Cai G-Q, Kerr EH, Han X, Li Q, Hu M, Buchasbaum DJ, Stockard CR, Grizzle WE,

Ding Q. S100A4 promotes cell migration and growth through focal adhesion kinase and

Src mediated dual signaling pathways in pancreatic cancer cells. Presented at the AACR

2013 Annual Meeting, Washington, DC, April 6-11, 2013.

356. Gurpinar E, Grizzle WE, Shacka JJ, Li N, Keeton AB, Piazza GA. A novel non-COX-

inhibitory sulindac derivative induces autophagic cell death by inhibiting Akt signaling in

lung cancer cells. Presented at the AACR 2013 Annual Meeting, Washington, DC, April

6-11, 2013.

357. Grizzle WE. Obtaining tissue from the Cooperative Human Tissue Network (CHTN).

Presented at the AACR 2013 Annual Meeting, Washington, DC, April 6-11, 2013.

358. Bovell L, Balananda-Dhurjati, Putcha K, Devadasan D, Bae S, Grizzle WE, Manne U.

Evaluationof the prognostic value of miRNA-181b and its target identification and

validation in colorectal cancers. Presented at the AACR 2013 Annual Meeting,


359. Kaur G, Srivastava SK, Arora S, Bhandwaj A, McClellan S, Scammell JG, Grizzle WE,

Owen LB, Fodstad O, Singh AP, Singh S. Functional role of FKBP51 in malignant

progression of melanoma. Presented at the AACR 2013 Annual Meeting, Washington,

DC, April 6-11, 2013.

360. Theodore S, Davis M, Rhim J. Grizzle WE, Turner T, Yates C. MicroRNA expression

profiling in African American and Caucasian prostate cancer. Presented at the AACR


361. Srivastava SK, Tyag N, Kaur G, Arora S, Bhardwaj A, Grizzle WE, Singh AP, Singh S.


Evidence supporting a role of ETV4 in pancreatic cancer pathogenesis. Presented at the

AACR 2013 Annual Meeting, Washington, DC, April 6-11, 2013.

362. Srivastava SK, Singh S, Bhardwaj A, Arora S, McClellan S, Grizzle WE, Singh AP.

Myb contributes to pancreatic cancer growth and metastasis. Presented at the AACR


363. Bhardwaj A, Singh S, Srivastava SK, Arora S, Hyde SJ, Honkanen RE, Grizzle WE,

Singh AP. Downregulation of protein phosphatase 2A promotes prostate cancer

progression and metastasis. Presented at the AACR 2013 Annual Meeting, Washington,

DC, April 6-11, 2013.

364. Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Keeton AB, Grizzle WE,

Piazza GA. Next generation sulindac. Presented at the AACR 2013 Annual Meeting,


365. Huang JS, Egger M, Grizzle WE, McNally LR. IGF1-receptor expression is regulated

by miR-100 in metastatic pancreatic cancer cells. Presented at the AACR 2013 Annual


366. Singh R, Gupta P, Grizzle WE, Lillard JW, Singh S. Differential expression of CC

chemokine receptor-9 in prostate cancer. Presented at the AACR 2013 Annual Meeting,


367. Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Grizzle WE, Owen LB,

Singh AP. An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer

cell invasiveness through upregulation of CXCR4. Presented at the AACR 2013 Annual


368. Klepczyk LC, Wei S, Brazelton JD, Keene KS, Bonner JA, LoBuglio AF, Forero A,

Grizzle WE, Yang ES. Correlation between poly (ADP-ribose) polymerase (PARP) and

phospho-p65 expression in human breast cancer. Presented at the ASCO Annual

Meeting, Chicago, IL, May 31-June 4, 2013.

369. Grizzle WE. Artifacts in immunostaining – Troubleshooting difficult cases. Presented

at the 39th

Annual National Society for Histotechnology Symposium/Convention,

Providence, RI, September 20-26, 2013.

370. Grizzle WE. Analysis of mucins by histochemical and immunohistochemical

techniques. To Be Presented at the 39th

Annual NSH Symposium/Convention,

Providence, RI, September 20-26, 2013.

371. Grizzle WE. Collecting human and animal tissues to support biomedical research:

Effects on the operations of anatomic pathology. To Be Presented at the 39th

Annual

NSH Symposium/Convention, Providence, RI, September 20-26, 2013.

372. Van Neste L, Van Criekinge W, Bigley J, Grizzle WE, Adams GW, Karney GP, Gaston

SM. Performance of an epigenetic assay to predict prostate cancer aggressiveness:

Comparing Gleason score and NCCN risk categories. Presented at the EAU Section of

Urological Research (ESUR) meeting in October 9-11, 2014, Glasgow, Scotland.


373. Grizzle WE. Limitations of the use of human prostate tissues in biomedical research.

To be presented at the Prostate Cancer Foundation 21st Annual Scientific Retreat,

Carlsbad, CA, October 23, 2014.

374. Gaston SM, Grizzle WE, Kittles R, Hayek J, Kolettis PN, Rais-Bahrami S, Nix J,

Gordetsky J, Adams GW, Kearney GP. The use of innovative prostate biopsy tissue print

techniques for molecular genomic, epigenomic and gene expression studies. Presented at

the 2015 AACR Annual Meeting, April 18-22, 2015, Philadelphia, PA.

375. Naik G, Chen D, Crowley M, Crossman D, Sexton KC, Grizzle WE, Mehta AN,

Sonpavde G. Whole exome sequencing (WES) of penile squamous cell carcinoma

(PSCC) identifies multiple recurrent mutations. To be presented at the 2016

Genitourinary Cancers Symposium, San Francisco, California, January 7-9, 2016.

376. Van Neste L, Stewart G, Gaston SM, Grizzle WE, Adams GW, Kearney GP, Epstein JI,

Harrison DJ, Partin AW, Van Criekinge W. Combined DNA-methylation intensity and

clinical risk score stratifies ipatients for high-grade disease. Presented at the 2016

Genitourinary Cancers Symposium, San Francisco, California.

377. Arend RC, Boone JD, Cooper SJ, Gilchrest A, Oelschlager DK, Grizzle WE, McGwin

G, Abhishek G, Straughn JM, Buchsbaum DJ. Targeting the Wnt/β-catenin pathway in

primary ovarian cancer with the porcupine inhibitor WNT974. Presented at the 2015

AACR Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, Poster

Presentation, Orlando, Florida, October 17-20, 2015.

378. Gaston SM, Kearns J, Adams GW, Rais-Bahrami S, Nix JW, Kolettis PN, Bryant JE,

DeGuenther MS, Oelschalger D, Otalil D, Grizzle WE. A biopsy-focused approach to

molecular studies of prostate cancer in African Americans: the Birmingham Alabama

Prostate Cancer Consortium (BAPrCa). To be presented at the 2016 Ninth AACR

Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and

the Medically Underserved, Poster Presentation, Fort Lauderdale, Florida, September 25-

28, 2016.

379. Gaston SM, Kearns J, Adams GW, Rais-Bahrami S, Nix JW, Kolettis PN, Bryant JE,

DeGuenther MS, Oelschlager D, Otali D, Grizzle WE. Satisfying the fatty acid demand

of prostate cancer: Outlier overexpression of genes involved in de novo synthesis vs fatty

acid uptake define two different and potentially synergistic prostate cancer phenotypes.

Presented at the 2017 Genitourinary Cancers Symposium ASCO, Poster Presentation,

Orlando, FL, February 16-18, 2017.

Oral Presentations

Scientific papers presented at international meetings

Grizzle, W.E.: "Growth Factors and Related Protooncogenes in Animal Research",

Annual Meeting of the Swiss Society of Histopathology, Lucerne, Switzerland, 1993

Grizzle, W.E., Myers, R.B.: "Antitumor Effects of Coumarin In Vitro", 21st German

Cancer Congress, Hamburg, Germany, 1994.


Grizzle, W.E.: "Prostatic Neoplasia: From PIN to Androgen Resistance", Ottawa

Regional Cancer Center, Ottawa, Ontario, Canada, June 16-19, 1998.

Grizzle, W.E.: "Colorectal Adenocarcinoma: A New Prospective on Prognosis Based on

Location of the Tumor and on Race of the Patient", Ottawa Regional Cancer Center,

Ottawa, Ontario, Canada, June 16-19, 1998.

Grizzle, W.E.: "Genetic and Epigenetic Changes in Prostate Cancer", U.S.-Japan

Cooperative Cancer Research Program: "Molecular Determinants of Preneoplasia and

Early Cancer Progression", Kauai, Hawaii, 1998.

Grizzle, W.E.: “Tissue Resources”; “Prostatic Neoplasia: From PIN to Androgen

Resistance”; “Colorectal Cancer: Molecular Phenotypes and Molecular Markers of

Prognosis”, XI IMSS (Mexican Institute of Social Security) Medical Research National

Forum, Cocoyoc, Morelos, Mexico; September 26-29, 2000.

Grizzle, W.E.: Invited Participant: European ISBER Meeting, Italy, October 15-24,

2004. Podium Presentation “Bias and other issues in providing human tissues for

research”

Grizzle, W.E.: “Strategies to Address Next Generation Challenges for BioBanking -

Avoiding Bias in Tissue Resources”, WW Biobank Summitt III, Stockholm, Sweden,

May 24-25, 2005.

Grizzle, W.E.: African Organization for Research and Training in Cancer (AORTIC)

Annual Meeting, “Developing Tissue Resources in a 3rd

World Environment”, Senegal,

Dakar, November 14-17, 2005.

Working Conference of Leaders in Biobanking, London, England, December 12-13,

2005.

Grizzle W.: Invited Participant: Lessons learned in diagnostic research. Alliance of

Glycobiologists for Detection of Cancer and Cancer Risk, Bethesa, MD. September 2-3,

2009

Grizzle, W.E.: Invited Participant: NCI, Office of Biorepositories and Biospecimen

Research, National Institutes of Health, caHUB User Group Workshop, September 8,

2009.

Aamodt R, Grizzle W. Workshop Title: Hominid Sample Research Resources.

Presentation: The model of the co-operative human tissue network for human samples.

Center for Academic and Research Training in Anthropogeny (CARTA), December 18-

19, 2009.

Grizzle WE, Sexton KC. Title: Designing and maintaining a tissue repository.

International Society for Biological and Environmental Repositories (ISBER) Annual

Meeting, British Columbia, Canada, May 15-18, 2012.

Grizzle WE, Sexton KC. Title: Designing and maintaining a tissue repository. Asian


Network of Research Resource Centers (ANRRC) Annual Meeting, Jeju Island, Korea,

October 17-19, 2012.

Grizzle WE, Sexton KC. Title: What biorepositories need to know about how

investigators plan to use human tissues in their research and the limitations of such use.

Presented at the International Society for Biological and Environmental Repositories

(ISBER) Annual Meeting, Sydney, Australia, May 5-9, 2013.

Grizzle WE. Title: Limitations in the use of human tissues in research: What

biorepositories and investigators need to know. Australasian Biospecimen Network

Association (ABNA) Conference 2016 14th

Annual Meeting on Biobanking: Blood,

Tissue & Beyond, Adelaide, Australia, October 13, 2016

Grizzle WE. Title: Out of the biobank and into the archives. The science of using new

and old samples. Australasian Biospecimen Network Association (ABNA) Conference

2016 14th

Annual Meeting on Biobanking: Blood, Tissue & Beyond, Adelaide,

Australia, October 14, 2016

Grizzle WE

Scientific papers presented at local and regional meetings

Invited lectures, workshops, etc. at national postgraduate courses and meetings and at

other universities

Grizzle, W.E.: "Tumor Biology", Cancer Management Course, American College of

Surgeons, 1987.

Grizzle, W.E.: Human Tissue, Use in Research and Laboratory Controls. College of

American Pathologists, Annual Meeting, 1991

Grizzle, W.E.: Invited Participant: National Cancer Institute Sponsored Consensus

Conference: Chemoprevention of Breast Cancer, 1993

Grizzle, W.E.: Invited Participant: NCI Consensus Conference Surrogate Endpoint

Markers in Breast, Colorectal and Prostate Cancer, 1993

Grizzle, W.E.: Tissue Resources to Support Breast Cancer Research", National Institutes

of Health Sponsored Conference: Breast Cancer Resources to Facilitate Research, 1994

Grizzle, W.E.: Invited Participant: National Action Plan on Breast Cancer - National

Biological Resource Banks Working Group. Tissue Procurement Workshop. Bethesda,

Maryland, September 18-19, 1996

Grizzle, W.E.: Invited Participant: Advisory Committee to the Director, National

Cancer Institute: Developmental Diagnostics Working Group - Development of Clinical

Resources, Bethesda, MD, November 5-6, 1996

Grizzle, W.E.: Invited Participant: NCI Sponsored Cancer Chromosome Aberration


Workshop, Bethesda, MD, March 4-5, 1997

Grizzle, W.E.: Invited Participant: NCI National Action Plan on Breast Cancer -

Informed Consent and IRB Review: A Model for Review and Discussion, Bethesda,

MD, June 21, 1997

Grizzle, W.E.: Invited Participant: International Society for Nutrition and Cancer

Conference, Irvine, CA, 1997

Grizzle, W.E.: Invited Participant: NCI Sponsored Breast Cancer Progress Review

Group (PRG) Roundtable, Bethesda, MD, September 14-16, 1997

Grizzle, W.E.: Invited Participant/Member: College of American Pathologists Ad Hoc

Committee on Stored Tissue/Genetic Privacy Meeting, Arlington, VA, May 2, 1998

Grizzle, W.E.: Invited Participant/Member: Selective Estrogen Receptor Modulator

(SERM) in Women with Newly Diagnosed Breast Cancer Investigator's Meeting,

Chicago, IL, July 1, 1998

Grizzle, W.E.: Invited Participant: NCI Sponsored Sixth SPORE Investigators'

Workshop. Rockville, MD, July 12-14, 1998

Grizzle, W.E.: Invited Participant: NCI Sponsored Informed Consent Field Test

Meeting, Chicago, IL, September 18, 1998

Grizzle, W.E.: "Variation of Prognostic Biomarkers in Colorectal Adenocarcinoma

Based on the Race of the Patient and Anatomic Location of the Tumor" - Kansas Cancer

Institute Research Round Table, Kansas City, KS, September 22, 1998.

Grizzle, W.E.: "Adenocarcinoma of the Prostate: From Prostatic Intraepithelial

Neoplasia to Androgen Resistance" - Grand Rounds Presentation, University of Kansas

Medical Center, Kansas City, KS, September 23, 1998.

Grizzle, W.E.: Invited Participant/Presentation: NCI Sponsored Seventh SPORE

Investigators' Workshop, Rockville, MD, July 11-13, 1999

Grizzle, W.E.: Invited Participant/Panelist: NCI Sponsored Workshop on "Prevention of

Prostate Cancer", Baltimore, MD, August 8-9, 1999

Grizzle, W.E.: Invited Participant/Member: International Society of Biological and

Environmental Repositories - Repository Management Meeting, Manassas, VA,

September 15, 1999

Grizzle, W.E.: Invited Participant/Presentation: American Cancer Society Meeting,

Henry Ford Hospital; Advisor, Tissue Resources, Henry Ford Medical Center, Detroit,

MI, September 15-17, 1999

Grizzle, W.E.: Invited Participant/Presentation: Selective Estrogen Receptor Modulator

(SERM) in Women with Newly Diagnosed Breast Cancer Investigator's Meeting,

Chicago, IL, September 17-18, 1999


Grizzle, W.E.: “Use of Biomarkers in Diagnosis, in Determining Prognosis, and as

Targets for Therapy”, Lecture, Update in Diagnostic Pathology Conference, Hilton Head

Island, SC, September 23 – 26, 1999.

Grizzle, W.E.: “Biomarkers for Cancer Prevention”, Lecture, UAB Comprehensive

Cancer Center Retreat, Birmingham-Jefferson Civic Center, Birmingham, AL, October

25, 1999.

Grizzle, W.E.: Invited Participant: NCI Sponsored Conference on Best Practices

Ensuring Confidentiality in the Conduct of Clinical Research, Bethesda, MD, December

1-2, 1999.

Grizzle, W.E.: Invited Participant: 8th

SPORE Investigators’ Workshop, Chantilly, VA,

July 9-11, 2000.

Grizzle, W. E.: Invited Participant: Network of Dentists, Oral Surgeons, Oral Oncologists

and Oral Pathologists to Acquire and Make Available Premalignant Oral Lesions,

Bethesda, MD, May 24, 2001.

Grizzle, W.E.: Invited Participant: Review Panel for National Cancer Institute Prostate

Cancer SPORE Grant Applications, San Antonio, TX, January 21-23, 2002.

Grizzle, W.E.: Invited Participant: Early Detection Research Network (EDRN) Steering

Committee Meeting, Houston, TX February 3-5, 2002.

Grizzle, W.E.: Invited Participant: Mammary MMHCC/Breast SPORE Exploratory

Workshop, Santa Fe, New Mexico, February 14-15, 2002.

Grizzle, W.E.: Invited Participant: NIH/EDRN Sponsored Gordon Research Conference

“New Frontiers in Cancer Detection”, Ventura, CA, March 11-15, 2002.

Grizzle, W.E.: Invited Participant: American Association for Cancer Research Annual

Meeting San Francisco, CA, April 6-10, 2002.

Grizzle, W.E.: Invited Participant: Experimental Biology Meeting, New Orleans,

Louisiana, April 20-21, 2002.

Grizzle, W.E.: Invited Participant: International Society for Biological and

Environmental Repositories (ISBER) Annual Meeting, Boston, MA, May 6-8, 2002.

Grizzle, W.E.: Invited Participant: Biological Stain Commission Annual Meeting,

Rockville, Maryland, June 6-7, 2002.

Grizzle, W.E.: Invited Participant: Cooperative Human Tsisue Network (CHTN)

Meeting, Las Vegas, Nevada, June 12-14, 2002.

Grizzle, W.E.: Invited Participant: SPORE Investigator’s Workshop / Annual Meeting,

Chantilly, Virginia, July 13-15, 2002.


Grizzle, W.E.: Invited Participant: Cancer Center Advisory Committee, University of

Kansas Medical Center, Kansas City, Kansas, August 22-23, 2002.

Grizzle, W.E.: Invited Participant: EDRN Steering Committee Meeting, Ann Arbor, MI,

September 3-5, 2002.

Grizzle, W.E.: Invited Participant: Presented Grand Rounds, Northwestern University,

Chicago, IL, September 9, 2002.

Grizzle, W.E.: Invited Participant: National Cancer Institute Study Section, Grant

Reviews, Rockville, MD, September 18, 2002.

Grizzle, W.E.: Invited Participant: HIPAA Privacy Rule Meeting – “Health Information

Databases & Repositories - Applying the Privacy Rule to Research” (speaker), Fairfax,

Virginia, September 19, 2002.

Grizzle, W.E.: Invited Participant: National Cancer Institute Sponsored Site Visit,

Bethesda, MD, September 23-25, 2002.

Grizzle, W.E.: Invited Participant: National Society for Histotechnologists Annual

Meeting, Long Beach, California, October 1-3, 2002.

Grizzle, W.E.: Invited Participant: EDRN Network Consulting Committee Meeting,

Washington, DC, October 4, 2002.

Grizzle, W.E.: Invited Participant: October 14 – 18 AACR Sponsored “Frontiers in

Cancer Prevention Meeting”, Boston, MA, October 14-18, 2002.

Grizzle, W.E.: Invited Participant: EDRN SELDI Meeting, San Antonio, TX, October 28,

2002.

Grizzle, W.E.: Invited Participant: CHTN Coordinating Committee Meeting, Nashville,

TN, November 12-13, 2002.

Grizzle, W.E.: Invited Participant: Ovarian SPORE related meeting with Duke

University, Drs. Burchuck and Duke, Durham, NC, November 20-21, 2002.

Grizzle, W.E.: Invited Participant: ISBER meeting, Washington, DC, December 6, 2002.

Grizzle, W.E.: Invited Participant: NIDDK / NCI Grant Review, Head of Study Section,

Washington, DC, December 9, 2002.

Grizzle, W.E.: Invited Participant: EDRN Validation Pre-Launch Meeting, Washington,

DC, December 10, 2002.

Grizzle, W.E.: Invited Participant: EDRN Steering Committee Meeting, Birmingham,

AL, January 29-31, 2003.

Grizzle, W.E.: Invited Participant: NCI-PLCO/NLST Steering Committee Meeting,

Santa Monica, CA, February 12-13, 2003.


Grizzle, W.E.: Invited Participant: NCI SPORE in Prostate and GU Cancer, Application

Reviewers Group Meeting, Bethesda, MD, February 26-28, 2003.

Grizzle, W.E: Invited Participant: U.S. & Canadian Academy of Pathology Meeting,

Washington, DC, March 22-23, 2003.

Grizzle, W.E.: Invited Participant: American Association for Cancer Research Annual

Meeting, Toronto, ON, April 4-9, 2003.

Grizzle, W.E.: Invited Participant: ISBER annual meeting. Philadelphia, PA, May 3-7,

2003.

Grizzle, W.E.: Invited Participant: Biological Stain Commission meeting, Rochester,

NY, May 18-20, 2003.

Grizzle, W.E.: Invited Participant: National Biospecimen Network Design Team

Meeting, Bethesda, MD, May 28, 2003.

Grizzle W.E.: Invited Participant: CHTN Coordinating Committee Meeting, Chicago,

IL, June 17-19, 2003.

Grizzle, W.E.: Invited Participant: EDRN Steering Committee Meeting, Pittsburgh, PA,

June 23-25, 2003.


SPORE Workshop, Baltimore, MD, July 8-10,

2003.

Grizzle, W.E.: Invited Participant: National Biospecimen Network Design Team

Meeting, Bethesda, MD, July 28-29, 2003.

Grizzle, W.E.: Invited Participant: Subcommittee on Human Tissue Procurement,

Wayne, PA, August 4-5, 2003.

Grizzle, W.E.: Invited Participant: Gordon Research Conference New Frontiers in

Cancer Detection and Diagnosis, Andover, NH, August 17-22, 2003.

Grizzle, W.E.: Invited Participant: Emory University/Prostate SPORE submission

meeting with Dr. Amin, Atlanta, GA, August 26-28, 2003.

Grizzle, W.E.: Invited Participant: PLCO Steering Committee Meeting, Chicago, IL,


Grizzle, W.E.: Invited Participant: NSN Meeting, Louisville, KY, October 17-23, 2003.

Grizzle, W.E.: Invited Participant: EDRN Meeting, Dallas, TX, February 1-4, 2004.

Grizzle, W.E.: Invited Participant: Brain SPORE Grant Review Meeting, San Diego,

CA, February 8-11, 2004.


Grizzle, W.E.: Invited Participant: Biomarker SPORE Review Meeting, Houston, TX,

February 15-16, 2004.

Grizzle, W.E.: Invited Participant: CaBig Meeting, Washington, DC, February 18-20,

2004. Podium Presentation “Tissue resources”

Grizzle, W.E.: Invited Participant: Biological Stain Commission By-Laws Meeting, Ft.

Lauderdale, February 27-29, 2004.

Grizzle, W.E.: Organizer: SELDI-MALDI Workshop, Presenter: “Mass Spectroscopy

Analysis: Analyzer Beware”, Seattle, WA, March 15-20, 2004.

Grizzle, W.E.: Invited Participant: Society of Toxicology Meeting, Baltimore, MD,

March 23-24, 2004. Podium Presentation “The molecular staging of colorectal cancer”

Grizzle, W.E.: Invited Participant: The Burnham Institute, PPG Grant Review

(Perucho), LaJolla, CA, April 14-15, 2004. / Presented Grand Rounds on 4/15/04 “Early

detection and progression of colorectal cancer”

Grizzle, W.E.: Invited Participant: Repository Meeting, Bethesda, MD, April 26, 2004.

Grizzle, W.E.: Invited Participant: PRIM&R Meeting, Boston, MA, May 4-6, 2004.

Podium Presentation “Regulatory issues in human collection and tissue banking”

Grizzle, W.E.: Invited Participant/Presenter: “Proteomics in the Early Detection and

Molecular Staging of Colorectal Cancer”, Henry Ford Health System, Detroit, MI, May

28, 2004.

Grizzle, W.E.: Invited Participant: SPORE Investigator’s Workshop, Baltimore, MD,

July 9-13, 2004. Podium Presentation “Use of biomarkers in early detection, diagnosis,

prognosis, and surrogate endpoints, applications to GI and pancreatic cancers”

Grizzle, W.E.: Invited Participant: EDRN GU Collaborative Meeting, Houston, TX,


Grizzle, W.E.: Invited Participant: NSH Annual Meeting, Toronto, Canada, September

18-23, 2004.

Grizzle, W.E.: Invited Participant: EDRN Breast/GYN Meeting, New York, NY,


Grizzle, W.E.: Invited Participant: III Annual and CaBig Meeting, Pittsburgh, PA,

October 4-8, 2004. Podium Presentation “Bias in data from multiplex assay methods.

Grizzle, W.E.: Invited Participant: CaBig meeting, Philadelphia, PA, November 7-9,

2004.

Grizzle, W.E.: Invited Participant: Gordon Research Conference, Santa Barbara, CA,

January 16-21, 2005.


Grizzle, W.E.: Invited Participant/Presenter: EDRN Steering Committee Meeting,

“Overcoming Bottlenecks: Ways to Synergize Efforts within and Outside the EDRN”,

Bethesda, MD, March 21-23, 2005.

Grizzle, W.E..: Invited Presenter: Medical Ground Rounds, UAB, “New Approaches to

Proteomics”.

Grizzle, W.E.: Invited Participant: NCI Biorepository Coordinating Committee Retreat,


Grizzle, W.E.: Invited Participant: CaBIG Meeting, Baltimore, MD, April 11-13, 2005.

Grizzle, W.E.: Invited Participant: AACR Meeting. Presentations: “Breast and Prostate

Clinical Prevention Trials, including Biomarker End-Point Evaluation” and “Human

Specimen Research: Promise, Problems and Practical Approaches” Anaheim, CA, April

15-21, 2005.


SPORE Investigators Workshop, Washington,

DC., July 9-12, 2005.

Grizzle, W.E.: Invited Discussion Leader and Panelist: NCI/NIH Biorepository Coordinating

Committee Workshop “Best Practices and Recommendations for Establishing and

Maintaining Biorepositories that Support Cancer Research”, July 18-20, 2005.

Grizzle, W.E.: Invited Participant/Speaker: “Biorepository 911: Biosafety”, NCI

Biospecimen Coordinating Committee Workshop Best Practices and Recommendations

for Establishing and Maintaining Biorepositories That Support Cancer Research,

Washington, DC, July 19, 2005.

Grizzle, W.E.: Invited Participant/Speaker: “Analysis of Tissue”, NCI Biospecimen

Coordinating Committee Workshop Best Practices and Recommendations for

Establishing and Maintaining Biorepositories That Support Cancer Research,

Washington, DC, July 19, 2005.

Grizzle, W.E.: Invited Participant/Keynote Speaker: Henry Ford Health System 6th

Annual Symposium on Experimental Therapeutics in Oncology: Targeting Cancer,

“Targeting Cancer – Uses of a Tissue Repository”, Detroit, MI, July 29, 2005.

Grizzle, W.E.: Invited Participant: CHTN Coordinating Committee Meeting,

Charleston, NC, August 9-10, 2005.

Grizzle, W.E.: Invited Participant: National Institute of Standards and Technology

(NIST) Meeting – Discussion Leader “Panel Discussion on Clinical Reference Materials

and Logistical Challenges”, Gaithersburg, MD, August 18-19, 2005.

Grizzle, W.E.: Invited Participant: Consensus Conference: AFIP Tissue Repository

Meeting, “What Makes a Tissue Repository Valuable?”, Washington, DC, August 30-31,

2005.

Grizzle, W.E.: “Clinical Synergy Report”, Eleventh EDRN Steering Committee

Meeting, September 19-22, 2005, Seattle, WA.


Grizzle, W.E.: “Importance of Standard Operating Procedures”, Eleventh EDRN

Steering Committee Meeting, September 19-22, 2005, Seattle, WA.

Grizzle, W.E.: “Preventing Bias in Tissue Repository”, United States Military Cancer

Institute Bio-Specimen Network Program, November 22, 2005, Bethesda, MD.

Grizzle, W.E.: “The Use of Molecular Markers in the Early Diagnosis and/or Prognosis

of Pancreatic Lesions”, Early Detection Research Network (EDRN) Pancreas Working

Group Meeting, January 6, 2006.

Grizzle, W.E.: “The Use of Paraffin Embedded Tissues in Analyses Using Real Time

Quantitative PCR”. Early Detection Research Network (EDRN) Scientific Workshop,

March 20-22, 2006, Philadelphia PA.

Grizzle, W.E.: “Establishing a Tissue Resource/Repository” Workshop – ISBER Annual

Meeting, Washington, DC, April 30 – May 2, 2006.

Grizzle, W.E.: Speaker/Discussion Leader, NIH Conference on Harmonization of Issues

Related to Tissue Resources, Washington, DC, May, 2006.

Grizzle, W.E.: “Challenges in FNA Analysis for Early Diagnosis.” Early Detection

Research Network (EDRN) 13th

Steering Committee Meeting, September 18, 2006,

Pittsburgh, PA.

Grizzle, W.E.: “Analysis of FNAs for Early Diagnosis” Breakout Session, Early

Detection Research Network (EDRN) 13th

Steering Committee Meeting, September 18,

2006, Pittsburgh, PA.

Grizzle, W.E.: “Pancreatic Reference Set.” Breakout Session, Early Detection Research

Network (EDRN) 13th

Steering Committee Meeting, September 18, 2006, Pittsburgh, PA.

Grizzle, W.E.: “EDRN Validation Study on the Detection of Prostate Cancer Using

SELDI Profiling.” Early Detection Research Network (EDRN) 13th

Steering Committee

Meeting, September 19, 2006, Pittsburgh, PA.

Grizzle, W.E..: Invited Presenter: “Tissue Resources: The Good, the Bad and the Ugly.”

Yale University Grand Rounds. October 28, 2010, New Haven, CT.

Grizzle, W.E.: “Tissue Repositories: The Good, the Bad and the Ulgy: What

Investigators Need to Know.” February 5, 2012, Deely Research Centre, British

Columbia Cancer Agency, Victoria, BC, Canada.

Invited lectures at local and regional courses and meetings

Grizzle WE. Workshop: Non-H and E Diagnosis. Symposium of the National Society

for Histotechnology Region III, 1982

Grizzle WE. Laboratory Evaluation of Adrenal Medullary and Related Endocrine


Tumors. American Society for Medical Technology, 1984

Grizzle WE, Clark L, Staples TC. Workshop: Technical Aspects of Histochemical

Silver Stains Including the Microwave Technique. Alabama Society for

Histotechnology, 1984

Grizzle WE. Quality Control in Anatomic Pathology and Histopathology. Reichert

Histology Symposium, 1985

Grizzle WE. AIDS Precautions, Alabama Society for Histotechnology, 1985.

Staples TC and Grizzle WE. "Tissue Identification" Alabama Society for

Histotechnology, 1985

Grizzle WE, Staples TC. Silver Stains in Endocrinology and Neuroendocrinology.

National Society for Histotechnology, Region III, 1986.

Grizzle WE, Staples T, Clark L. A Review and Workshop of the Technical

Considerations of Silver Stains. Proceedings of the 1988 Symposium of the National

Society for Histotechnology

Grizzle WE. Scientific Session: AIDS in 1990 - A look at the predictions. Alabama

Society for Histotechnology, 1990

Grizzle WE. Growth Factors and Protooncogenes - Identification and Importance in

Diagnostic Histopathology. National Society for Histotechnology, Annual Meeting,

1991

Staples TL, Grizzle WE. Silver Staining in Diagnostic Histopathology. Wet Workshop,

National Society for Histotechnology, Annual Meeting, 1991

Grizzle WE. Theoretical Concepts of Silver Stains. National Society for

Histotechnology, Annual Meeting, 1991

Fredenburgh J, Grizzle WE. Safety in the Tissue Processing Histology Laboratory:

Toxic Chemicals to Biohazards. National Society for Histotechnology, Annual Meeting,

1992.

Grizzle WE, Fredenburgh J. The Endocrine System of Man Versus Animals:

Comparison Using Immunohistology and Special Stains. National Society for

Histotechnology, Annual Meeting, 1992.

Grizzle WE. Histological Silver Stains - Theory and Application. National Society for

Histotechnology, Annual Meeting, 1992.

Grizzle WE, Fredenburgh J, Myers RB, Oelschlager D, Srivastava S. Effect of Fixation

on Immunohistochemical Analysis of Tumor Markers. Annual Meeting of Biological

Stain Commission, 1993.

Grizzle WE and Fredenburgh J. Safety and Compliance in the Histology Laboratory:


Biohazards to Toxic Chemicals. National Society for Histotechnology Annual Meeting,

1993.

Grizzle WE and Fredenburgh J. Safety and Compliance in the Histology Laboratory:

Biohazards to Toxic Chemicals. National Society for Histotechnology Annual Meeting,

1994.

Grizzle WE. Histological Silver Stains "Theory and Application". National Society for

Histotechnology Annual Meeting, 1994.

Grizzle WE and Fredenburgh J. Fixation: Impact of Histopathology from H&E Stains

to Immunostaining. National Society for Histotechnology, 1994.

Grizzle WE and Fredenburgh J. Laboratory Safety Workshop. National Society for


Grizzle WE and Harkins L. Advanced Methods of Immunohistochemistry: Fixation,

Antigen Retrieval, Quantitation and Recent Developments. National Society for


Grizzle WE and Fredenburgh J. Laboratory Safety Workshop. Alabama Society for

Histotechnology, Regional Meeting, 1995.

Grizzle WE and Fredenburgh J. Laboratory Safety Workshop. Florida Society for

Histotechnology, Regional Meeting, 1995.

Grizzle WE. Quality Control of Special Stains: Involvement of External Organizations

- Biological Stain Commission and College of American Pathologists. Florida Society

for Histotechnology, Regional Meeting, 1995.

Grizzle WE and Myers RB. "Cytoplasmic Biomarkers" presented at the Prostatic

Intraepithelial Neoplasia Workshop sponsored by the American Cancer Society/National

Cancer Institute, Bethesda, MD, July 1-2, 1996.

Grizzle WE. "Factors Affecting Immunostaining from Fixation to Antigen Retrieval."

2nd Annual Advanced Immunohistochemistry Seminar, Birmingham, AL, August 15-17,

1996.

Fredenburgh J. and Grizzle WE. Fixation: Impact of Histopathology from Hematoxylin

and Eosin Stains to Immunostaining. National Society for Histotechnology Annual

Meeting, Albuquerque, NM, October 19-23, 1996.

Grizzle WE. It's All in the Silver Family. Alabama Society for Histotechnology,

Regional Meeting, Mobile, AL, November 15-17, 1996.

Fredenburgh J. and Grizzle WE. Safety and Compliance in the Laboratory. National

Society for Histotechnology, Annual Meeting, Salt Lake City, UT, September 12-17,

1998.

Fredenburgh J. and Grizzle WE. Troubleshooting Complex Histochemical Stains.


National Society for Histotechnology, Annual Meeting, Salt Lake City, UT, September

12-17, 1998.

Fredenburgh J. and Grizzle WE. Safety and Compliance in the Laboratory: Biohazards

to Toxic Chemicals. National Society for Histotechnology, Annual Meeting, Providence,

RI., October 16-21, 1999.

Fredenburgh J. and Grizzle WE. Special Stains: Their Chemical Mechanism. National

Society for Histotechnology, Annual Meeting, Providence, RI., October 16-21, 1999.

Grizzle WE. Molecular Phenotypes of Neoplastic Lesions from Diagnosis to Molecular

Targeting. UAB Comprehensive Cancer Center Seminar Series, January 10, 2001.

Grizzle WE. Prostate Cancer from Prostatic Intraepithelial Neoplasia to Androgen

Independence. Seminar University of Texas, Southwestern Medical Center, Dallas, TX.

July 24, 2001.

Grizzle WE. “The Relationship of Early Breast Neoplasia in Animals and Man.” Breast

SPORE Exploratory Workshop. Santa Fe, New Mexico. February 14, 2002.

Grizzle, W.E.: “Androgen Regulation of Prostate Cancer”, Northwestern University

Department of Pathology, Kansas City, KS; September 9, 2002.

Grizzle WE. The Early Detection, Diagnosis and Staging of Colorectal Neoplasia Using

Molecular Markers and/or Protein-Fingerprints as Identified by SELDI-TOF-MS.

International Academy of Pathology Meeting, Washington, DC, March 22-23, 2003.

(Invited presentation).

Grizzle, WE. Use of biomarkers in early detection, diagnosis, prognosis, and surrogate

endpoints, applications to GI and pancreatic cancers. Presented at the 12th

SPORE

Investigators’ Workshop, Baltimore, MD, July 13, 2004. (Podium presentation).

Grizzle WE. Prognostic factors in colorectal cancer vary with race. Presented at the

MSM/TU/UAC Cancer Center Partnership’s 3rd

Summer Institute in Birmingham, AL.

July 22-23, 2004 during breakout session (9:000-10:00am). Presentation repeated 10:15-

11:15am.

Grizzle WE. Issues in the collection, processing and banking of human tissue specimens

– the importance of bias in collections. Presented at the ISBER 2005 Annual Meeting,

Seattle, WA, May 1-4, 2005.

Grizzle WE. The Cooperative Human Tissue Network as an example of prospective

tissue collections. Presented at the ISBER 2005 Annual Meeting, Seattle, WA, May 1-4,

2005.

Grizzle WE. Tissue specimen resources of the Early Detection Research Network.

Presented at the ISBER 2005 Annual Meeting, Seattle, WA, May 1-4, 2005.

Grizzle WE. The development of informatics and databases to support

tissue/environmental repositories. Workshop presented at the ISBER 2005 Annual


Meeting, Seattle, WA, May 1-4, 2005.

Grizzle WE. Interaction of Clinical Laboratories in Research. Presented at the Alabama

Pathology and Laboratory Professionals Meeting, (Meeting sponsored by the Alabama

Society for Histotechnology and the Alabama State Society for Clinical Science), May

18, 2005.

Grizzle WE. Strategies to Address Next Generation of Challenges for Biobanking.

Presented at the World Wide Biobank Summit III, Stockholm, Sweden, May 25, 2005.

Grizzle WE. Translational Research Seminar Series, Presented at the University of

Alabama at Birmingham, Birmingham, AL, November 1, 2005.

Huffman DM, Grizzle WE, Bamman MM, Kim JS, Eltoum IA, Elgavish A, Nagy TR.

SIRT1 is significantly elevated in mouse and human prostate cancer. UAB Cancer

Center Retreat, Birmingham, AL, October 30, 2006.

Grizzle WE and Sexton KC. Establishing a tissue resource/repository. Presented at the

ISBER 2007 Annual Meeting, Singapore, May 30 – June 2, 2007.

Grizzle WE. Bias in Tissue Collection, Processing and Storage, University of Michigan.

September 2007.

Grizzle WE. New approaches in the study of DCIS/LCIS. Presented at the Inter-

SPORE meeting, Boston, MA, March 12-14, 2009.

Grizzle WE. Even a blind pig can sometimes find a mushroom or accidental discoveries

are made by observations followed by careful searches. Presented at the National Society

for Histotechnology Annual Meeting 2009, Birmingham, AL.

Grizzle WE. The importance of tissue resources to research. Presented at the University

of Kansas Cancer Center, April 26, 2010.

Grizzle, WE. Tissue Resources: The Good, the Bad and the Ugly, Yale University

Grand Rounds. October 28, 2010, New Haven, CT.

Grizzle WE. Factors that affect the quality and usefulness of tissues in biomedical

research. Presented at the 8th

Australasian Biospecimen Network Annual Meeting,

Brisbane, December 2, 2010.

Grizzle WE. Biobanking and tissue repositories. Presented at the 6th

Annual Academic

Surgical Congress, February 1, 2011.

Grizzle WE, Sexton KC, Henderson M, Sobel, Hewitt R, Jewell S. The facilitation of

communication among repositories by the international society for biological and

environmental repositories (ISBER). Presented at the 4th


Network (BRN) Symposium, Bethesda, MD, March 28-29, 2011.

Grizzle WE. Return of research results: stakeholder prospective and practical

implementation issues biobank perspective. Presented at the 2011 ISBER Meeting,


Arlington, VA, May 18, 2011.

Grizzle WE. What investigators need to know about solid tissues in planning their

research and in optimization of the use of tissues in research. Presented at the UAB

Pathology Center for Clinical and Translational Science (CCTS) Mini-Workshops in

Tissue Biorepositories, March 13, 2012.

Grizzle WE, Edberg. What investigators need to know about the use of bodily fluids in

research: blook (serum, plasma, buffy coats, whole blood, clot), urine and saliva.

Presented at the UAB Pathology Center for Clinical and Translational Science (CCTS)

Mini-Workshops in Tissue Biorepositories, March 20 and April 17, 2012.

Grizzle WE, Miller J. Regulatory and ethical issues in biorepositories from IRB-HIPAA

to safety. Presented at the UAB Pathology Center for Clinical and Translational Science

(CCTS) Mini-Workshops in Tissue Biorepositories, August 21, 2012.

Grizzle WE. Review of major issues in biorepository operations. Presented at the UAB

Pathology Center for Clinical and Translational Science (CCTS) Mini-Workshops in

Tissue Biorepositories, August 28, 2012.

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