CURRICULUM VITAE Srinivasan ThyagaRajan€¦ · CURRICULUM VITAE Srinivasan ThyagaRajan PERSONAL...
Transcript of CURRICULUM VITAE Srinivasan ThyagaRajan€¦ · CURRICULUM VITAE Srinivasan ThyagaRajan PERSONAL...
CURRICULUM VITAE
Srinivasan ThyagaRajan
PERSONAL INFORMATION
Date of Birth: May 25, 1964
Marital Status: Married, Two children
Address: 127/8 F4, First Main Road, Alwarthirunagar Annexe, Chennai 600087
Telephone: 9940201794
E-mail: [email protected]
EDUCATION Madras Veterinary College
Madras, India. Veterinary Science B. V. Sc. 1981-1987
Kansas State University, KS, U.S.A. Physiology Ph. D. 1988-1993
(Neuroendocrinology)
PREVIOUS POSITIONS AND APPOINTMENTS
6/1988-9/1993 Graduate Research Assistant with Teaching Responsibilities, Dept. of
Anatomy and Physiology, College of Veterinary Medicine, Kansas State
University, KS, U. S. A.
10/1993-1/1997 Postdoctoral fellow, Dept. of Neurobiology and Anatomy, School of
Medicine and Dentistry, University of Rochester, NY, U. S. A.
2/1997-6/1998 Research Assistant Professor, Dept. of Neurobiology and Anatomy,
University of Rochester, NY, U. S. A.
7/1998-6/2001 Assistant Professor, Dept. of Pathology and Human Anatomy,
Center for Neuroimmunology, School of Medicine,
Loma Linda University, CA, U. S. A.
7/2001-8/2003 Assistant Adjunct Professor, Dept. of Anatomy and Neurobiology,
Susan Samueli Center for Complementary and Alternative Medicine,
College of Medicine, University of California, Irvine, CA, U. S. A.
9/2003-7/2006 Associate Research Professor, Division of Human Anatomy, Dept. of
Pathology and Human Anatomy, School of Medicine, Loma Linda
University, Loma Linda, CA, U. S. A.
8/2006-6/2008 Adjunct Associate Research Professor, Division of Human Anatomy,
Dept. of Pathology and Human Anat., School of Medicine, Loma Linda
University, Loma Linda, CA, U. S. A.
1/2007-1/2008 Interim Head of the Department, Department of Biotechnology
(~6 months) SRM University, Kattankulathur 603 203, Kanchipuram District, Tamil
Nadu, INDIA
07/2010-2013 Honorary Consul General of Michigan State University, MI, USA
for India representing College of Veterinary Medicine, MSU
07/2011-2013 Adjunct Associate Professor, Department of Pathobiology and
Diagnostic Investigation, Michigan State University, MI, USA
12/2012-05/2019 Head, Department of Biotechnology, School of Bioengineering, SRM
IST, India
10/2006-05/2019 Professor, Department of Biotechnology, SRM IST, India
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HONORS 1983-1987 Recipient of Tamil Nadu Agricultural University Merit Scholarship
Award, Madras Veterinary College, India.
1987 Gold Medals and Books (Physiology), Madras Veterinary College, India.
1993 Sigma Xi Travel Award, Kansas State University, KS, U. S. A.
MEMBERSHIP IN PROFESSIONAL SOCIETIES
Indian Academy of Neuroscience, 2007-present
Society for Neuroscience, 1991- 2016
The Endocrine Society, 1992-2002
Psychoneuroimmunology Research Society, 2000-2004
The Gerontological Society of America1991-1993
Sigma Xi 1993
Society of Phi Zeta 1991-1993
UNIVERSITY AND DEPARTMENTAL COMMITTEES AT SRM UNIVERSITY, INDIA
Development of curriculum and syllabi for B. Tech. (Biotech.) course for 2007-2010
B. Tech. (Biotech.) Immunology Project Coordinator, Dept. Biotechnology, 2008, 2009.
B. Tech. (Biotech.) Medical Biotechnology Project Coordinator, Dept. Biotechnology, 2010
M. Tech. (Biotech.) Research Project Coordinator, Dept. Biotechnology, 2007-08.
Associate Superintendent, Exam Cell. Supervision of University examinations. 2007-08.
Organizing Secretary, Recent Advances in Bioengineering, SRM IST, February 7-9,
2008. International workshop and conferences by the six departments of the School of
Bioengineering with delegates over 2000.
Organized the inauguration of Biotechnology Student Association with 3 eminent speakers and
arranged 9 seminars given by entrepreneurs, industrialists, and scientists. 2009-10
Local Sectional Secretary: Animal, Veterinary, and Fishery Sciences, Indian Science Congress
Association Meeting, SRM University, January 3-7, 2011.
Organized an one-day workshop on Innovative Methodologies in Teaching of Life Science and
Biomedical Science Laboratory Courses in collaboration with Mahatma Gandhi-
Doerenkamp Center (MGDC) for Alternatives to Use of Animals in Life Science
Education, Bharathidasan University, Tiruchy at SRM University, February 26, 2011.
Organized the inauguration of Biotechnology Student Association with 2 eminent speakers and
arranged 3 seminars given by clinician, industrialist, and scientist. 2011-12
Development of curriculum and syllabi for B. Tech. and M. Tech. (Biotech.) courses-2013
Regulations
Development of curriculum and syllabi for B. Tech. and M. Tech. (Biotech.) courses-2015
Regulations
Development of curriculum and syllabi for B. Tech. (Biotech.) course-2018 Regulations
PARTICIPATION IN ACADEMIC AND RESEARCH REVIEW COMMITTEES
The Wellcome Trust, U. K.; Ad hoc reviewer, 2000.
Member, Board of Studies of Basic Sciences Faculty, Tamil Nadu Veterinary and Animal
Sciences University, 2009-2012.
Head, Pharmacology and Clinical Sciences Research Program, World Noni Research
Foundation, Chennai, April 2013-present
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Reviewer of grants under SPARSH (Social Innovation Programme for Products Affordable &
Relevant to Societal Health), Biotechnology Industry Research Assistance Council
(BIRAC), DBT. September 8, 2016
Reviewer of grants, DST. 2015, 2016
Executive Council Member, National Academy of Biological Sciences, India. September 2016-
present
MANUSCRIPT REVIEW FOR JOURNALS
Neuroimmunomodulation
International Journal of Psychology
Brain Behavior and Immunity
Brain Research
Neurobiology of Aging
Journal of Pharmacology and Experimental Therapeutics
Journal of Neuroimmunology
Endocrine
Proceedings of Indian National Science Academy- B
Pharmacological Research
Endocrinology
Oncology Research International
AGE
Psychiatry Research
Neuroscience Letters
BioMed Research International
Experimental Biology and Medicine
Drug and Chemical Toxicology
American Journal of Physiology-Endocrinology and Metabolism
Molecular Psychiatry
International Immunopharmacology
EDUCATIONAL CONTRIBUTIONS
Graduate Education
Gross Anatomy (Medical, Dental, and Veterinary)
Veterinary Gross Anatomy I (AP 700, 6 credit hours), Kansas State University, KS.
Fall Semester, 1991 and 1992: Laboratory Instructor. Contact hours: 250
hours/semester.
Medical Gross Anatomy (ANAT 511), Loma Linda University, CA. Fall and Winter
Quarter, 1999. Laboratory instruction to medical students.
Human Gross Anatomy (Medicine 500), University of California, Irvine, College of Medicine.
2002-2003. Lectures and laboratory instruction to medical students.
Medical Gross Anatomy (ANAT 521-524), Loma Linda University, CA. 2005-2006.
Laboratory instruction and review of Anatomy to first-year medical students.
Human Anatomy for Dentists (ANAT 509) Loma Linda University, CA. Spring Quarter, 2006.
Laboratory instruction on head and neck to first year dental students.
Neuroscience
Neuroscience (ANAT 537), Loma Linda University, CA. Spring Quarter, 2006. Lecture on
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Hypothalamus, neural pathways, and functions to medical students.
Psychoneuroimmunology involving Behavior, Neuroscience, Endocrinology, and Immunology
Mind-Body interactions and health outcomes (HPRO 515), Loma Linda University, CA.
Fall Quarter, 1999 and 2000. Lectures on Psychoneuroimmunology and Cancer.
Immune system: Public health applications (HPRO 575), Loma Linda University, CA.
Fall Quarter, 2003 and 2004. Lectures on neuroendocrine-immune basis for cancer
pathogenesis and psychosocial influences on cancer pathogenesis and therapy.
Immunology for Pharmacy Students (RXPS 571), Loma Linda University, CA. Winter
Quarter, 2005 and 2006. Lectures on interactions between the nervous, endocrine, and
immune systems and immunopharmacology.
Cellular Mechanism and Integrated Systems II (IBGS 512 & 513), Loma Linda University,
CA. Winter and Spring Quarters, 2006. Lectures on Neuro-Endocrine-Immune
Interaction and its role in diseases to graduate students.
Graduate course in Psychoneuroimmunology (ANAT 557), Loma Linda University, CA.
Spring Quarter, 2006. As a Co-Director of the course assisted in developing the course
and lecture material, selection of peer-reviewed manuscripts for group
discussion, and grading of the students. Lectures and moderating group discussions on
a variety of topics in psychoneuroimmunology to graduate students.
Biotechnology, Genetic Engineering, and Bioinformatics at SRM University, INDIA
Immunology Laboratory (BT 208), Even semester 2006-07.Immunology lab training to II year
B. Tech. (Biotechnology).
Immunology BT 207: Odd semester 2007-08, II year B. Tech. (Biotech.).
BI 356: Even Semester 2008-09, III year B. Tech. (Bioinfo.).
BT0205: Course Coordinator, Odd Semesters 2008-09, 2009-10, 2010-11, 2011-
12, 2012-13, 2013-14II year B. Tech. (Gen. Eng. and Biotech.).
BT1010/15BT205: Odd semesters 2014-15, 2015-16, 2017-18, 2018-19
Seminar: BT 504, Even semester 2006-07.I year M. Tech. (Biotech.).
BT 509, Odd semester, 2007-08, I year M. Tech. (Biotech.).
Signal transduction and cell signaling (BT 560), Even semester 2006-07.I year M. Tech.
(Biotech.).
Cancer Biology BT0615: Odd semester 2009-10. II Year M. Tech. (Biotech.).
BT0325: Odd Semester 2010-11, 2011-12, 2012-13, 2013-14, 2014-15. III Year
B. Tech. (Biotech.).
BI0358:Even Semester 2009-10, 2010-11. III Year B. Tech. (Bioinfo.)
BT1051:Odd semester 2015-16
Cell culture and Hybridoma technology (GN 304), Even semesters 2006-07. 2007-08.2008-09
Lectures to III year B. Tech. (Genetic Engineering).
Immunotechnology BT 455:Odd semester, 2007-08, 2008-09, 2009-10. IV year B. Tech.
(Biotech.).
BT 558: Even semester, 2007-08, I year M. Tech. (Biotech.).
Biology for Engineers (GE 0102), Even semester, 2007-08, I year B. Tech. (ICE).
Course Coordinator, Even semester, 2009-2010, 2010-11, 2011-12 and taught I year B.
Tech. (FPE).
Biochemistry BT0102: Course Coordinator, Even Semester, 2010-11, 2011-12, 2012-13. I
Year B. Tech. (Biotech.).
BT1004: Even Semester, 2013-14, 2014-15
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Cell Biology BT0104: Course Coordinator, Even Semester, 2011-12, 2012-13. I Year B.
Tech. (Biotech.).
BT1003/15BT201: Even Semester, 2013-14, 2014-15, 2016-17, 2017-18,
Human Physiology and Health BT1002: Even Semester, 2013-14, 2014-15, 2015-16
Neurobiology BT1021: Odd Semester, 2015-16
Cellular and Molecular Neuroscience BT1072/15BT211E: Even semester, 2015-16,
2016-17, 2017-18, 2018-19
Developmental Biology 15BT207E: Odd semester, 2018-19
Training of Undergraduate and Graduate Students University of Rochester, NY.
Undergraduate students: Valerie Levy (1994-1995)
J. Cory Kalvass (1996-1997).
Loma Linda University, CA.
Summer Research Scholars
(2nd year medical students): R. Kerr (June-August, 1998)
Brian Teruya (June-August, 1999)
University of California Irvine, CA.
Minority Biomedical Research
Support Program & Biol. 199: Danielle Campbell, July-December, 2002,
Biol 199: Catherine Lajoie, July-December, 2002,
Loma Linda University, CA.
Minority Summer Student: Paola Garcia, June-August, 2005
M.S. thesis committee member: Schari Flowers, 2004-2006
Guidance to Graduate students: Jeff Carter, Brooke Millar, Sam Perez, and
Dorian Silva, 2003-2006
SRM IST, Kattankulathur, INDIA
B. Tech. (Biotech.) Students: Harini Krishnan; 2009-2011
Miti Mishra and Ranvijay Singh; 2010-2014
S. Gopinath; 2011-2013
R. Karthik Ramakrishnan and Vishak Raman;
2012-2013
Soha Chhaya, Sushrut Shitoot, T. C. ThyagaRajan,
2013-2014
Shaili Gour, T. Kannan, Mantavya Patel, M. M.
Hariharan, V. Prasanna, 2013-16
M. Tech. (Biotech.) Students: Biswa Behera and Vikram Sabapathy;.2005-07.
Ramyapriya, Sam Masih, and Mohd. Zeeshan;
2007-09
A. Sindhu and Preetam Bala; 2009-10
Utsav Sharma and Varun Sharma; 2010-2011
Uday Pratap and Aparna Mohanty; 2011-2012
Anushree Patil, Prathamesh Kale, and Himanshu
Sharma; 2012-2013
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Anurupa Bhattacharya (External), 2014
Rahul Nair, 2014-2015
Ph. D. (Biotech.) Full-time: Hannah Priyanka 2009-2014
Uday P. Pratap 2012-2017
Hima, L. 2013-
R. Vasantharekha 2012-2018
PAST GRANT SUPPORT
U. S. A.
Somerset Pharmaceuticals Inc., Desmethylselegiline in an in vivo model of neuronal
degeneration and altered immune responses. 9/15/95-6/30/98. Co-P. I. (David L. Felten,
P. I.), 100% effort. $224,000 (TC).
U. S. Army Medical Research and Materiel Command Breast Cancer Research Program, Grant
DAMD17-96-1-6214, “Deprenyl and Protection against Mammary tumors.” 1996-1999.
Co-P. I. (David L. Felten, P. I.), 85% effort. $601,310 (TC)
Intramural Grant, Loma Linda University, “Sympathetic Noradrenergic Neuronal Modulation
of Th1Vs Th2 Cytokines in Aging: Effects of Deprenyl Treatment.” 2000-2001. P. I.
$6,000.
The Japan Foundation for Aging and Health: Japan-U. S. Cooperative Research Program for
Longevity Sciences. “Desmethyldeprenyl and Neural-Immune Interactions.” 1/1/01-
12/31/01. P. I. $5,000.
Intramural Grant, Loma Linda University, “Estrogen and Reproductive Aging.” 2003-2005.
P. I. $50,000.
India
SRM University. “Estrogen: A Neuroprotective or Proinflammatory Hormone?” August 2009-
July 2010. P. I. Harini Krishnan, II B. Tech. (Biotech.), Co-I. Rs. 0.65 Lakhs.
Department of Science and Technology, Government of India. “Modulation of Neural-Immune
Signaling by Estrogen in Reproductive Aging.” March 2008-February 2011. P. I. F.
NO. SR/SO/HS-46/2007. Rs. 37.44 Lakhs.
World Noni Research Foundation, Chennai. “Physiological significance of Noni
phytochemicals on the Neuro-Endocrine-Immune system.” 2010-2012. P. I. Order
No.: FFEP-CRP-O8-O02. Rs. 10.00 Lakhs.
Department of Biotechnology, Government of India. “Neuroendocrine-Immune Interactions in
Mammary Tumorigenesis.” 2009-2012. P. I. Order No.: BT/PR9199/Med/30/12/2007.
Rs. 40.25 Lakhs.
Ministry of Agriculture, GoI, Coconut Development Board, Kerala. “Health benefits of dietary
intake of Virgin coconut oil on neural-immune network.” 2014-2016. P. I.
F.No.1345/2013 Tech. Rs. 26.29 Lakhs
INVITED SPEAKER 1. Aging: Hypothalamic catecholamines and neuroendocrine functions. Department of
Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New
York, June 18. 1993.
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2. First International Conference on Immunology and Aging: In a symposium titled Neuro-
Endocrine-Immune System Interaction. National Institutes of Health Campus, Bethesda, MD.
June 16-19, 1996.
3. In Vivo Neuroimmunology and L-deprenyl effect on brain catecholamines/serotonin. Somerset
Pharmaceuticals, Tampa, FL. October 21, 1996.
4. Anti-tumor effect of deprenyl in rats with carcinogen-induced mammary tumors. 1st Annual
University of Rochester Cancer Center Scientific Symposium, Genesee County Museum,
Mumford, NY. November 4, 1996.
5. Sympathetic modulation of immunity in aging. Twenty-first International Symposium on Brain
and the Bio-defense System. Division of Brain Sciences, The Taniguchi Foundation, Kyoto,
Japan. January 19-22, 1998.
6. L-deprenyl-induced inhibition of mammary tumor growth is associated with altered neural
activity and immune function in rats. Era of Hope Meeting, Department of Defense Breast
Cancer Research Program, Atlanta. June 8-11, 2000.
7. Modulation of neuroendocrine-immune signaling by deprenyl and desmethyldeprenyl in aging
and breast cancer. Fifth International National Institute for Longevity Sciences Workshop,
Interventions: Part III, Obu-shi, Aichi, Japan, November 30-December 1, 2000. Co-Chairman
of the scientific session: Antioxidants I.
8. Sprouting of noradrenergic nerve fibers, immune modulation and protection from mammary
tumors. Symposium: Sympathetic nervous system modulation of immune function: role in
immune function abnormalities in the elderly, in cancer, and in autoimmune disease. Annual
meeting of the Psychoneuroimmunology Research Society, Utrecht, The Netherlands, May 19,
2001.
9. Neuroendocrine regulation of immune reactivity: Effects of propargylamines in aging and
breast cancer. Department of Anatomy and Neurobiology, University of California, Irvine.
May 25, 2001 10. Neural Influences on Immune Reactivity in Reproductive Aging. Biomedical Research
Seminar, Loma Linda University, CA. April 22, 2004 11. Communications between the Neuroendocrine System and Immune System in Aging and
Mammary Cancer. School of Biotechnology, SRM University, Kattankulathur, India. November 4, 2006.
12. Neuroimmunomodulation of splenic sympathetic noradrenergic (NA) nerve fibers by estrogen in rats. Silver Jubilee Conference of Indian Academy of Neurosciences, Varanasi, India. November 23, 2007.
13. Fundamental Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious Diseases and AIDS. NIPER, Chandigarh, India. December 11-13, 2008.
14. Female Reproductive Aging and Mammary Cancer: Involvement of Neural-immune Interactions. Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, MI, USA. March 18, 2010.
15. Current Status in Cancer Biology. Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai. February 27, 2012
16. Pharmacological Properties and Clinical Applications of Morinda citrifolia. Noni Search 2014; Ninth national symposium “Noni for Everyone,” Goa. September 27, 2014
17. A conundrum: Does immune system operate in isolation or regulated by neuroendocrine system? Immunocon-2014, Madurai Kamaraj University, Madurai. December 13, 2014
18. Neuroendocrine-Immune system and Homeostasis and Neuroendocrine-Immune interactions in Aging and Age- related diseases. Academies’ Lecture Workshop, Vels University, Chennai. March 12, 2015
19. Medicinal plants in the treatment of cancer and neurodegenerative diseases. Second World Noni Congress: Noni and Medicinal plants for Inclusive Growth and Wellness. SRM University. March 20, 2016
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20. Reproductive Aging: Key neural-immune interactions during early middle age in brain and lymphoid organs. Symposium on Neural Functions of Aging Brain organized by ICUBR & SSH and RGCB, Thiruvananthapuram, September 28, 2016.
PUBLICATIONS
1. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1 stimulates the
release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo. Life Sci.
48:925-930, 1991.
2. ThyagaRajan, S., Meites, J. and Quadri, S. K. Underfeeding-induced suppression of
mammary tumors: counteraction by estrogen and haloperidol. Proc. Soc. Exp. Biol. Med.,
203:236-242, 1993.
3. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1ß increases
5-hydroxyindoleacetic acid release in the hypothalamus in vivo. Brain Res. Bull., 31:745-748,
1993.
4. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Correlations of catecholamine
release in the medial preoptic area with proestrous surges of luteinizing hormone and prolactin:
effects of aging. Endocrinology 135:119-126, 1994.
5. ThyagaRajan, S., Meites, J. and Quadri, S. K. Deprenyl treatment reinitiates estrous cycles,
reduces serum prolactin and decreases the incidence of mammary and pituitary tumors in old
acyclic rats. Endocrinology 136:1103-1110, 1995.
6. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Cyclic changes in the release of
norepinephrine and dopamine in the medial basal hypothalamus: effects of aging. Brain Res.,
689:122-128, 1995.
7. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Cyclic and age-related changes in
norepinephrine concentrations in the medial preoptic area and arcuate nucleus. Brain Res.
Bull., 38:561-564, 1995.
8. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Tyrosine hydroxylase and DOPA
decarboxylase activities in the medial preoptic area and arcuate nucleus during the estrous
cycle: effects of aging. Brain Res. Bull., 42:265-271, 1997.
9. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Anti-tumor effect of L-deprenyl in rats with
carcinogen-induced mammary tumors. Cancer Letters 123:177-183, 1998.
10. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Restoration of sympathetic noradrenergic
nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized
and old Fischer 344 rats. J. Neuroimmunol., 81:144-157, 1998.
11. ThyagaRajan, S., Madden, K.S., Kalvass, J. C., Dimitrova, S., Felten, S. Y. and Felten, D. L.
L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of
noradrenergic nerve fibers in the spleens of old F344 rats. J. Neuroimmunol., 92:9-21, 1998.
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12. ThyagaRajan, S., Stevens, S. Y. and Felten, D. L. Region-specific alterations in the
concentrations of catecholamines and indoleamines in the brains of young and old F344 rats
after L-deprenyl treatment. Brain Res. Bull., 48:513-520, 1999.
13. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Effects of L-deprenyl
treatment on noradrenergic innervation and immune reactivity in lymphoid organs of young
F344 rats. J. Neuroimmunol., 96:57-65, 1999.
14. ThyagaRajan, S. and Quadri, S. K. L-deprenyl inhibits tumor growth, reduces serum
prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced
mammary tumors. Endocrine, 10:225-232, 1999.
15. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Inhibition of tumor growth
by L-deprenyl involves neural-immune interactions in rats with spontaneously developing
mammary tumors. Anticancer Res., 19:5023-5028, 1999.
16. ThyagaRajan, S. and Quadri, S. K. L-deprenyl stimulates the release of catecholamines in the
rat medial basal hypothalamus in vivo. Neurosci. Lett., 270:79-82, 1999.
17. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Restoration of splenic
noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-
deprenyl and L-desmethyldeprenyl. Int. J. Immunopharmacol., 22:523-536, 2000.
18. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Anti-tumor effect of L-
deprenyl is associated with enhanced central and peripheral neurotransmission and immune
function in rats with carcinogen-induced mammary tumors. J. Neuroimmunol., 109:95-104,
2000.
19. Bellinger, D. L., Stevens, S. Y., ThyagaRajan, S., Lorton, D., and Madden, K.S. Aging and
sympathetic modulation of immune function in Fischer 344 rats: Effects of chemical
sympathectomy on primary antibody response. J. Neuroimmunol., 165: 21-32, 2005.
20. Bellinger, D. L., Silva, D., Millar, B. A., Molinaro, C., Ghamsary, M., Carter, J., Perez, S.,
Lorton, D., Lubahn, C., Araujoa, G. and ThyagaRajan, S. Sympathetic nervous system and
lymphocyte proliferation in the Fischer 344 rat spleen: a longitudinal study.
Neuroimmunomodulation, 15(4-6):260-271, 2008
21. Perez, S., Silva,D., Millar, B., A.,Molinaro, C., Carter, J., Bassett, K., Lorton, D., Garcia, P.,
Tan, L., Lubahn, C., ThyagaRajan, S. and Bellinger, D. L. Sympathetic innervation of the
spleen in male Brown Norway rats: A longitudinal aging study. Brain Res.,1302:106-117,
2009.
22. ThyagaRajan, S., Madden, K.S., Teruya, B., Stevens, S. Y., Felten, D. L. and Bellinger, D. L.
Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary
lymphoid organs in female Fischer 344 rats. J. Neuroimmunol., 233:54-64, 2011.
23. Perez, S., Kozic, B., Molinaro, C., ThyagaRajan, S., Ghamsary, M., Lubahn, C., Lorton, D.
and Bellinger, D. L. Chronically lowering sympathetic activity protects sympathetic nerves in
spleens from aging F344 rats. J. Neuroimmunol., 247:38-51, 2012
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24. Priyanka, H.P., Bala, P., Ankisettipalle, S. and ThyagaRajan, S. Bacopa monnieri and L-
deprenyl differentially enhance the activities of antioxidant enzymes and the expression of
tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-B pathways in the spleen
of female Wistar rats. Neurochem. Res., 38:141-152, 2013.
25. ThyagaRajan, S.,Madden, K.S., Boehm, G. W., Stevens, S. Y., Felten, D. L. and Bellinger, D.
L. L-deprenyl reverses age-associated decline in splenic norepinephrine, IL-2 and IFN-
production in old female F344 rats. Neuroimmunomodulation,20:72-78, 2013.
26. ThyagaRajan, S.,Tran, L., Molinaro, C. A., Gridley, D. S., Felten, D. L. and Bellinger, D. L.
Prevention of mammary tumor development through neuroimmunomodulation in the spleen
and lymph nodes of old female Sprague-Dawley rats by L-deprenyl.
Neuroimmunomodulation20:141-151, 2013.
27. Priyanka H., Singh, R. V., Mishra, M., and ThyagaRajan, S. Diverse age-related effects of
Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities,
and intracellular targets in splenocytes of F344 male rats. Int. Immunopharmacol. 15:260-274,
2013.
28. Priyanka H., Sharma, U., Gopinath, S., Sharma, V., Hima, L., and ThyagaRajan, S. Menstrual
cycle and reproductive aging alters immune reactivity, NGF expression, antioxidant enzyme
activities, and intracellular signaling pathways in the peripheral blood mononuclear cells of
healthy women. Brain Behav. Immun. 32, 131–143, 2013
29. Priyanka H., Krishnan, H. C., Singh, R. V., Hima, L., and ThyagaRajan, S. Estrogen
modulates in vitro T cell responses in a concentration- and receptor dependent manner: effects
on intracellular molecular targets and antioxidant enzymes. Mol. Immunol. 56(4):328–339,
2013.
30. Priyanka, H.P. and ThyagaRajan, S. Selective modulation of lymphoproliferation and
cytokine production via intracellular signaling targets by 1- and 2-adrenoceptors and
estrogen in splenocytes. Int. Immunopharmacol.17:774–784, 2013.
31. Kale, P., Mohanty, A., Patil, A., Mishra, M., Pratap, U.P., Priyanka, H.P. and ThyagaRajan, S.
Estrogen modulates neural–immune interactions through intracellular signaling pathways and
antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats. J.
Neuroimmunol. 267:7-15, 2014.
32. Priyanka, H.P., Singh, R.V., Pratap, U.P. and ThyagaRajan, S. Estrogen modulates β(2)-
adrenoceptor-induced cell-mediated and inflammatory immune responses through ER-α
involving distinct intracellular signaling pathways, antioxidant enzymes, and nitric oxide. Cell
Immunol. 292:1-8, 2014.
33. Pratap, U.P., Anand, K., Yasmine, F., Hima, L., Priyanka, H.P., ThyagaRajan, S.
Phytochemicals in Morinda citrifolia fruit selectively modulate age-associated immunity and
antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats.
J Recept Signal Transduct Res. 2015 Oct 8:1-13.
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34 Pratap, U.P., Sharma, H.R., Mohanty, A., Kale, P., Gopinath, S., Hima, L., Priyanka, H.P.,
ThyagaRajan, S. Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric
oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats. Int
Immunopharmacol. 29(2):591-598, 2015
35. Pratap, U.P., Patil, A., Sharma, H.R., Hima, L., Chockalingam, R., Hariharan, M. M., Shitoot,
S., Priyanka, H.P., ThyagaRajan, S. Estrogen-induced neuroprotective and anti-inflammatory
effects are dependent on the brain areas of middle-aged female rats. Brain Res. Bull. 124:238-
253 2016.
36. Pratap, U.P., Hima, L., Priyanka, H.P., ThyagaRajan, S. Noni (Morinda citrifolia L.) fruit
juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats.
J. Ethnopharmacol. 198:363-371, 2017
37. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., Srinivasan, A.V., ThyagaRajan, S.
Interrelationship between Mini-Mental State Examination scores and biochemical parameters
in patients with mild cognitive impairment and Alzheimer's disease. Geriatr Gerontol Int.
17(10):1737-1745, 2017
38. Ravichandran, K. A., Karrunanithi, S., Hima, L., Pratap, U.P., Priyanka, H.P., ThyagaRajan,
S. Estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth
factor through free radical generation in the thymus and mesenteric lymph nodes of middle‐aged ovariectomized female Sprague–Dawley rats. Clin. Exp. Neuroimmunol. 8: 341-350,
2017.
39. Pratap, U.P., Priyanka, H.P., Ramanathan, K.R., Raman, V., Hima, L., ThyagaRajan, S. Noni
(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes
of old F344 rats. J Integr Med. 16(3):199-207, 2018.
40. Perez, S.D., Molinaro, C.A., Tan, L., ThyagaRajan, S., Lorton, D., Bellinger, D. L.
Sympathetic neurotransmission in spleens from aging Brown-Norway rats subjected to reduced
sympathetic tone. J Neuroimmunol. 324:1-15, 2018.
Reviews
1. Madden, K. S., ThyagaRajan, S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Age-
associated alterations in sympathetic neural interactions with the immune system. Dev. Comp.
Immunol., 21:479-486, 1997.
2. Madden, K. S., ThyagaRajan, S. and Felten, D. L. Alterations in sympathetic noradrenergic
innervation in lymphoid organs with age. Ann. N. Y. Acad. Sci., 840:262-268, 1998.
3. ThyagaRajan, S. and Felten, D. L. Modulation of neuroendocrine-immune signaling by L-
deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech. Ageing Dev., 123:
1065-1079, 2002.
12
4. Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., Molinaro, C.,
Lubahn, C. and Lorton, D. Innervation of lymphoid organs: Clinical implications. Clinical
Neurosci. Res., 6(1-2):3-33, 2006.
5. Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., Molinaro, C.,
Lubahn, C. and Lorton, D. Sympathetic modulation of immunity: Relevance to disease. Cell
Immunol., 252:27-56, 2008.
6. ThyagaRajan, S. and Priyanka, H.P. Bidirectional communication between the
neuroendocrine system and the immune system: relevance to health and diseases. Annals of
Neurosci., 19(1):40-46, 2012.
7. ThyagaRajan, S., Priyanka, H.P. and Pundir, U. P. Aging alters sympathetic noradrenergic
innervation and immune reactivity in the lymphoid organs: Strategies to reverse neuro-immune
senescence. Online journal. http://www.brainimmune.com. July 29, 2012
8. ThyagaRajan, S., Hima, L., Pratap, U.P., Priyanka, H.P., Vasantharekha, R. Estrogen-induced
neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and
lymphoid organs. J. Chem. Neuroanat. 2019 Jan;95:6-12, 2019.
Book Chapters
1. ThyagaRajan, S., Madden, K.S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Sympathetic
modulation of immunity in aging. In: Brain and Biodefence, Oomura, Y. and Hori, T. (Eds.),
Japan Scientific Societies Press, Tokyo and Karger, Switzerland, 27-38, 1998.
2. Bellinger, D. L., Madden, K.S., Lorton, D., ThyagaRajan, S. and Felten, D. L. Age-related
alterations in neural-immune interactions and neural strategies in immunosenescence. In:
Psychoneuroimmunology, Ader, R., Felten, D. L. and Cohen N. (Eds.), Academic Press, New
York, Third Edition, Volume 1, 241-286, 2001.
3. Bellinger, D. L., ThyagaRajan, S., Lorton, D., Madden, K.S., Tran, L. and Felten, D. L.
Psychoimmunology Today - Mechanisms Mediating the Effects of Psychological Status on the
Immune System. In: The Psychoimmunology of Cancer, Lewis, C. E., Barraclough, J., and
O’Brien, R. (Eds.), Second Edition, Oxford University Press, Oxford, 4-99, 2002.
4. Bellinger, D. L., ThyagaRajan, S.,Damjanovic, A. K., Millar, B., Lubahn, C. and Lorton, D. An
Overview of Neural-Immune Communication in Development, Adulthood, and Aging. In:
Immunotoxicology and Immunopharmacology, Luebke, R. W., House, R., and Kimber, I. (Eds.),
Third Edition, CRC Press, Florida, 489-507, 2006.
5. ThyagaRajan, S., Arun, M., Masih, S., Ramyapriya, M. and Mohammed, Z. Fundamental
Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious
Diseases and AIDS. In: Proceedings of the International Conference on Biotechnological
Approaches to Neuroimmunomodulation and Infectious Diseases, Singh, P. P. and Donahoe,
R.M. (Eds.), 461-480, 2008.
13
Proceedings of Conferences 1. Priyanka, H., Pundir, U., Mohanty, A., Singh, R., Hima, L., ThyagaRajan, S. In vitro effects
of Noni fruit juice on the age-related modulation of proliferation of lymphocytes, IFN
production, and antioxidant enzyme activities in the splenic lymphocytes of F344 rats. In:
Proceedings of Noni Search 2011; Sixth national symposium “Noni-A panacea for wellness,
Rethinam, P. and Marimuthu, T. (Eds.), 54-68, 2011.
2. Pundir, U.P., Priyanka, H.P., Yasmine, F., Mohanty, A., Singh, R., Mishra, M., Hima, L.,
ThyagaRajan, S. In vitro effects of Noni fruit juice on the age-related modulation of
proliferation of lymphocytes, IFN production, and antioxidant enzyme activities in the draining
lymphocytes of F344 rats. In: Proceedings of Noni Search 2012; Seventh national symposium
“Noni-The tool for wellness, Rethinam, P. and Marimuthu, T. (Eds.), 136-149, 2012.
3. Pratap, U.P., Ramakrishnan, K.R., Raman, V., Patil, A.P., Kale, P.P., Sharma, H.R., Singh,
R.V., Priyanka, H.P., ThyagaRajan, S. In vivo effects of Morinda citrifolia fruit juice on
lymphocytes proliferation, cytokine production, nitric oxide level and intracellular signaling
pathways in spleen and draining lymph nodes isolated from old F344 rats. Proceedings of
Eighth National Symposium, "Noni for Sustainable Wellness," p 184-196, 2013
4. Pratap, U.P., Patel, M., Hima, L., and ThyagaRajan, S. In vivo effects of Divine Noni Gold on
Cholinesterase activities and nitric oxide production in different brain areas of old F344 male
rats. Proceedings of Ninth National Symposium,“ Noni for Everyone”, p. 144-153, 2014.
Books
1. Biology for Engineers. S. ThyagaRajan, N. Selvamurugan, M. P. Rajesh, R. A. Nazeer,
Richard W. Thilagaraj, S. Barathi, and M. K. Jaganthan. Tata McGraw-Hill, New Delhi, 2012.
ISBN-13:978-1-12-143993-1; ISBN-10:1-12-143993-4
Author of Chapters 4 (Molecular machines) and 5 (Nervous system, immune system, and cell
signaling), pp. 126-205.
ABSTRACTS
1. Palazzolo, D. L., ThyagaRajan, S. and Quadri, S. K. Effects of aging on in vitro
catecholamine release. Gerontological Society of America Abstracts 29:93a, 1989.
2. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Changes in norepinephrine and
dopamine contents in the hypothalamus during the afternoon of proestrus. Kansas Academy of
Science Abstracts 9:41, 1990.
3. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin induces the release of
dopamine and its metabolite from the hypothalamus in vivo. Society for Neuroscience
Abstracts 16(2):971, 1990.
4. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on mammary tumors and on brain
neurotransmitters. Kansas Academy of Science Abstracts 10:34, 1991.
5. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Changes in the concentration of
catecholamines and their metabolites in middle-aged animals during the afternoon of proestrus.
Kansas Academy of Science Abstracts 10:23, 1991.
14
6. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. The in vivo release of
catecholamines (CA) from the medial preoptic area (MPA) during the estrous cycle in rats:
effects of aging. Endocrine Society Abstracts 73:1023, 1991.
7. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Age-related changes in
catecholamines released from the medial basal hypothalamus (MBH) of conscious, freely
moving female rats. Third IBRO World Congress of Neuroscience Abstracts 3:228, 1991.
8. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on brain neurotransmitters (NT) in old
male rats. Society for Neuroscience Abstracts 17(1):369, 1991.
9. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Aromatic L-aminoacid
decarboxylase activity in the hypothalamus (HT) during the estrous cycle: effects of aging.
Society for Neuroscience Abstracts 17(1):347, 1991.
10. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on body weight and organ weights in
old female rats. KansasAcademy of Science Abstracts 11:44, 1992.
11. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Release of 5-hydroxyindoleacetic
acid (5-HIAA) from the medial preoptic area (MPA) during different stages of estrous cycle:
effects of aging. Kansas Academy of Science Abstracts 11:30, 1992.
12. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on neurotransmitters (NT) in the
medial basal hypothalamus (MBH) and striatum (ST) of old female rats. The FASEB Journal
6:A2034, 1992.
13. ThyagaRajan, S. and Quadri, S. K. Deprenyl stimulates the release of catecholamines and 5-
hydroxyindoleacetic acid from the medial basal hypothalamus in vivo. Endocrine Society
Abstracts 74:431, 1992.
14. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Effects of aging on the monoamine
oxidase activity in the hypothalamus. Ninth International Congress of Endocrinology Abstracts
9:556, 1992.
15. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1ß induces the release of
5-hydroxyindoleacetic acid (5-HIAA) from the hypothalamus in vivo. Society for Neuroscience
Abstracts 18(1):766, 1992.
16. ThyagaRajan, S. and Quadri, S. K. Effects of feed restriction on mammary tumor growth and
hypothalamic neurotransmitters in rats. Society for Neuroscience Abstracts 18 (1):114, 1992.
17. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Age-related changes in the in vivo
release of 5-hydroxyindoleacetic acid (5-HIAA) from the medial basal hypothalamus (MBH) of
female rats. The Gerontologist 32:218, 1992.
18. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Tyrosine hydroxylase activity in the
hypothalamus during the estrous cycle: effects of aging. The Gerontologist 32:217, 1992.
15
19. ThyagaRajan, S. and Quadri, S. K. Deprenyl-induced suppression of carcinogen-induced
mammary tumor. growth in rats. Endocrine Society Abstracts 75:528, 1993.
20. Quadri, S. K., MohanKumar, P. S., ThyagaRajan, S., Palazzolo, D. L. and Sakamoto, K. Age-
related changes in hypothalamic monoamines and estrous cycles: effects of dietary restriction.
Endocrine Society Abstracts 77:P1-103, 1995.
21. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Deprenyl inhibits the development of
mammary tumors in rats. Society for Neuroscience Abstracts 21 (3):1629, 1995.
22. Felten, D. L., ThyagaRajan, S. and Felten, S. Y. L-Deprenyl induces recovery of splenic
sympathetic nerves and enhances some immune functions in aged rats. The Gerontologist
35:127, 1995.
23. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Deprenyl partially restores the age-related
loss of sympathetic noradrenergic innervation in the spleens of F344 rats. Society for
Neuroscience Abstracts 22 (3):1793, 1996.
24. ThyagaRajan, S., Madden, K.S., Kalvass, J. C., Dimitrova, S., Felten, S. Y. and Felten, D. L.
Deprenyl increases IL-2 production, NK cell activity, and partially prevents the age-related loss
of sympathetic noradrenergic innervation in the spleens of F344 rats. Society for Neuroscience
Abstracts 23 (1):718, 1997.
25. ThyagaRajan, S., Madden, K.S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Age-
associated alterations in norepinephrine concentration in lymphoid organs of female F344 rats.
Research Perspectives in Psychoneuroimmunology VIII. Neuroimmunomodulation 5:50, 1998.
26. Kerr, R., ThyagaRajan, S., Bellinger, D.L., Felten, D.L. Interleukin-2 (IL-2)-induced
activation of c-fos proto-oncogene immunoreactivity in the rat brain. J. Investigative Med.,
47(2):35A, 1999.
27. ThyagaRajan, S., Madden, and Felten, D. L. L-deprenyl-induced inhibition of mammary
tumor growth is associated with altered neural activity and immune function in rats.
Department of Defense Breast Cancer Research Program meeting, Era of Hope, Proceedings,
volume II, 682, 2000.
28. ThyagaRajan, S. and Felten, D. L. L-Deprenyl- and L-desmethyldeprenyl-induced restoration
of splenic noradrenergic nerve fibers and immune functions in old F344 rats. Society for
Neuroscience Abstracts 26 (1):1183, 2000.
29. ThyagaRajan, S. and Felten, D. L. Deprenyl: A modulator of neuroendocrine-immune
interactions in breast cancer. Cancer Detection and Prevention, 24 (Supplement 1): Abstract
216, 2000.
30. ThyagaRajan, S. and Felten, D. L. Modulation of neuroendocrine-immune signaling by
deprenyl and desmethyldeprenyl in aging and breast cancer. 5th International NILS Workshop,
Interventions: Part III, Abstract, 2000.
16
31. ThyagaRajan, S. Effects of L-deprenyl and L-desmethyldeprenyl on neuroendocrine-immune
interactions in aging and breast cancer. Brain Behav. Immun., 15:123, 2001.
32. ThyagaRajan, S., Bellinger, D. L., Nance, D. M., and Karsten, A. H. Estrogen-induced
inhibition of sympathetic noradrenergic (NA) neuronal activity in the spleens of male and female
rats. 11th Annual meeting of the PNIRS at Titisee, Germany, 2004.
33. Bellinger, D. L., Karsten, A.H., Siva, D., Schmidt, E., Molinaro, C., ThyagaRajan, S., Lubahn,
C., and Lorton, D. Age effects on T-lymphocyte function in short and long-lived rats with age-
related differences in sympathetic innervation of the spleen. 11th Annual meeting of the PNIRS,
2004.
34. Karsten A. H. , Bellinger, D. L., Gridley, D. S. and ThyagaRajan, S. Sympathetic modulation
of mammalian prostate cancer. 11th Annual meeting of the PNIRS, 2004.
35. Clarke, C., Karsten, A.H., Gridley, D.S., ThyagaRajan, S., Molinaro, C., Bellinger, D.L.
Sympathetic modulation of mammalian prostate cancer. LLU-NIH Initiative for Minority
Student Development Annual Symposium
36. Bellinger, D. L., Millar, B., Flowers, S., Damjanovic, A. K., Nance, D. M. and ThyagaRajan,
S. Estrogen and immunity: Neuromodulation by splenic sympathetic noradrenergic (NA) nerve
fibers in rats. 12th Annual meeting of the PNIRS at Denver, 2005.
37. Damjanovic, A. K., Carter, J., Gridley, D. S., ThyagaRajan, S., Molinaro, C. and Bellinger, D.
L. Sympathetic Modulation of Mammalian Prostate Cancer. 12th Annual meeting of the
PNIRS at Denver, 2005.
38. Millar, B., Perez, S. D., Carter, J. L., Flowers, S. R., Evelsizer, S., Alberto, S., ThyagaRajan,
S., Molinaro, C. A., Wood, C. and Bellinger, D. L. Aging alters sympathetic response to
immunization with KLH in Fischer 344 rats. Presented at the 13th Annual Meeting of the
Psychoneuroimmunology Research Society May 31 – June 3, 2006 in Miami, Florida.
39. Perez, S. D., Molinaro, C. A., Vyas, S., Millar, B., Carter, J., Wood, C., ThyagaRajan, S., and
Bellinger, D. L., Chronically reducing sympathetic activity in the spleen during middle age
does not reverse the age-related increase in -AR-stimulated cAMP production in splenocytes.
Presented at the 13th Annual Meeting of the Psychoneurommunology Research Society May
31 – June 3, 2006 in Miami, Florida.
40. Carter, J. L., Damjanovic, A. K., Molinaro, C. A., Vyas, S., Gridley, D. S., ThyagaRajan, S.
and Bellinger, D. L. Sympathetic modulation of mammalian prostate cancer in vitro. Presented
at the 13th Annual Meeting of the Psychoneurommunology Research Society May 31 – June 3,
2006 in Miami, Florida.
41. ThyagaRajan, S. Neuroimmunomodulation of splenic sympathetic noradrenergic (NA) nerve
fibers by estrogen in rats. Annals of Neuroscience, 14:62, 2007
17
42. ThyagaRajan, S.A Union between Biotechnology and Neuroimmunoendocrinology: Its
Implications in Health and Diseases. Proceedings of Recent Advances in Bioengineering, SRM
University. Feb 7-9, 2008
43. ThyagaRajan, S., Arun, M., Masih, S., Ramyapriya, M. and Mohammed, Z. Fundamental
Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious
Diseases and AIDS. Abstracts of the International Conference on Biotechnological
Approaches to Neuroimmunomodulation and Infectious Diseases, p57, 2008.
44. Priyanka, H.,Bala P, Sindu A, Harini K, and ThyagaRajan, S. In Vitro effects of 17beta-
estradiol alone or in association with adrenergic agents on lymphocytes. 5th Federation of
Asian and Oceanian Neuroscience Societies (FAONS) Congress - 2010 & XXVIII Annual
Meeting of Indian Academy of Neurosciences, Lucknow, India. November 25 - 28,
2010.Annals of Neuroscience, 17: p90.
45. Harini K, Priyanka P H, Preetam B, Sindhu A, and ThyagaRajan S. In vivo effects of 17β-
estradiol on the Antioxidant enzyme activities in the Peripheral organs and Brain Areas in
female Wistar rats.5th Federation of Asian and Oceanian Neuroscience Societies (FAONS)
Congress - 2010 & XXVIII Annual Meeting of Indian Academy of Neurosciences, Lucknow,
India. November 25 - 28, 2010. Annals of Neuroscience, 17: p99.
46. Bala P, Sindu A, Priyanka H, Harini K, and ThyagaRajan, S. Modulation of antioxidant
enzyme activity by Bacopa monnieraand L-deprenyl in the lymphoid organs and brain areas of
female Wistar rats: A comparative study. 5th Federation of Asian and Oceanian Neuroscience
Societies (FAONS) Congress - 2010 & XXVIII Annual Meeting of Indian Academy of
Neurosciences, Lucknow, India. November 25 - 28, 2010. Annals of Neuroscience, 17: p94.
47. Priyanka H., Sharma, U., Sharma, V., and ThyagaRajan, S. Co-incubation of 17 beta-
estradiol with splenic lymphocytes: Effects on lymphocyte functions and modulation by
adrenergic receptor agonists. Society for Neuroscience Abstracts 390.06/VV28, 2011.
48. Sharma, U., Sharma, V., Priyanka H., and ThyagaRajan, S. Alterations in cytokine
production and antioxidant enzyme levels in reproductive aging in Indian women. Society for
Neuroscience Abstracts 926.12/VV77, 2011.
49. Patil, A.P., Sharma, H., Mishra, M., Pundir, U. P., Priyanka H., and ThyagaRajan, S. In vivo
effects of 17β-estradiol on the antioxidant enzyme activities in brain areas of Sprague-Dawley
female rats. Annals of Neurosciences. Vol 19, pp. 39, 2012
50. Priyanka H., Pundir, U. P., and ThyagaRajan, S. In vitro effects of 17β-estradiol on splenic
lymphocytes on Sprague-Dawley rats are mediated by suppression of NO production: effects
on modulation of lymphocyte function by adrenergic agonists and antagonists. Annals of
Neurosciences. Vol 19, pp. 50, 2012
51. Sharma, H., Mohanty, A., Kale, P.P., Raman, V., Pundir, U. P., Priyanka H., and
ThyagaRajan, S. Alterations in antioxidant enzyme activities and immunity by estrogen in the
draining lymph nodes of female Sprague-Dawley rats. Annals of Neurosciences. Vol 19, pp.
52, 2012.
18
52. Ramakrishnan, K.R., Raman, V., Singh, R.V., Kale, P.P., Pundir, U. P., Priyanka H., and
ThyagaRajan, S. Noni fruit juice modulates cytokine production and antioxidant enzyme
activities in draining lymph nodes of old F344 male rats. Annals of Neurosciences. Vol 19, pp.
68, 2012.
53. Mishra, M., Priyanka H., and ThyagaRajan, S. Age-associated in vitro effects of Donepezil on
cytokine levels (IL-2 and IFN-γ) and anti-oxidant enzyme activity in splenic lymphocytes of
Fischer344 rats. Annals of Neurosciences. Vol 19, pp. 59, 2012.
54. Kale, P.P., Mohanty, A., Sharma, H.,Patil, A.P., Ramakrishnan, K.R., Pundir, U. P., Priyanka
H., and ThyagaRajan, S. Effects of estrogen treatment on antioxidant enzyme activity and
immunomodulation in the spleen of middle-aged Sprague-Dawley rats. Annals of
Neurosciences. Vol 19, pp. 67, 2012.
55. Singh, R.V., Priyanka H., and ThyagaRajan, S. In vitro effects of Bacopa monnieri (Brahmi)
on age-dependent proliferation of splenic lymphocytes, modulation of cytokine production and
antioxidant enzyme activities in male F344 rats. Annals of Neurosciences. Vol 19, pp. 70,
2012.
56. Gopinath, S., Hima, L., Sharma, U., Sharma, V., Priyanka H., and ThyagaRajan, S.
Neuroendocrine-immune interactions in female reproductive aging. Annals of Neurosciences.
Vol 19, pp. 72, 2012.
57. Pundir, U. P., Patil, A.P., Gopinath, S., Priyanka H., and ThyagaRajan, S. In vivo effects of
Noni fruit juice on brain antioxidant activities and splenic lymphocyte proliferation, IL-2 and
IFN-γ production in old F344 male rats. Annals of Neurosciences. Vol 19, pp. 83, 2012.
58. Priyanka, H.P., Thiyagaraj, A., Hopper, W., ThyagaRajan, S. In silico modelling and
simulation of neuroendocrine-immune modulation through adrenergic and estrogen receptor-
mediated signals in lymphocytes. Annals of Neurosciences, Vol. 20, p. 66, 2013
59. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., ThyagaRajan, S. Neuropsychological
Analysis in Indian patients with dementia. Annals of Neurosciences, Vol 20, p. 55, 2013
60. Priyanka, H. P., Pratap, U. P., Hima, L., Vasantharekha, R., Puspharani, A., and ThyagaRajan,
S. Spirituality alters cell-mediated immune functions but not humoral immune functions in Indian
women with metastatic breast cancer. 41st Annual Conference of Indian Immunology Society,
IMMUNOCON-2014. P. 128.
61. Pratap, U. P., Sharma, H., Patil, A., Hima, L., Priyanka, H. P., and ThyagaRajan, S. Estrogen-
induced up regulation of NF-kB is accompanied by an increase in IFN-g and nitric oxide
production via Akt/m-TOR pathways in the lymphocytes draining lymph nodes of middle-aged
female rats. 41st Annual Conference of Indian Immunology Society, IMMUNOCON-2014. P.
104.
62. Hima, L., Priyanka, H. P., Pratap, U. P., Vasantharekha, R., and ThyagaRajan, S. Age-
associated alterations in immunity in healthy Indian men and women. 41st Annual Conference
of Indian Immunology Society, IMMUNOCON-2014. P. 122-123.
19
63. Ramasamy Vasantharekha, Hima, L., Pratap, U. P., Priyanka, H. P., Swarnalingam, T.,
Srinivasan, A. V., and ThyagaRajan, S. Peripheral cell-mediated and humoral immune
dysfunction associated with cognitive impairment and Alzheimer’s disease. 41st Annual
Conference of Indian Immunology Society, IMMUNOCON-2014. P. 123.
64. Priyanka, H.P., Pratap, U.P., Hima, L., Vasantharekha, R., and ThyagaRajan S. (2014)
Correlative assessment of spirituality-induced effects on the neuroendocrine-immune network:
Effects on cell-mediated immune functions in Indian women with metastatic breast cancer.
International Symposium on Translational Neuroscience and XXXII Annual Conference of the
Indian Academy of Neurosciences. p. 114-115.
65. Hima, L., Vasantharekha, R., Shitoot, S., Pratap, U.P., Priyanka, H.P., and ThyagaRajan, S.
(2014) Correlative analysis of proinflammatory markers with Mini-Mental State
Examination(MMSE) Indian patients with Cognitive dysfunction. International Symposium on
Translational Neuroscience and XXXII Annual Conference of the Indian Academy of
Neurosciences. p. 122-123.
66. Patel, M., Hima, L., Pratap, U.P., Kannan, T., Gour, S., Vasantharekha, R., Priyanka, H.P., and
ThyagaRajan, S. (2014) Age-related alterations in LPS-induced proliferation, cytokine
production and antioxidant enzyme activities correlative with serum cortisol in healthy Indian
men. International Symposium on Translational Neuroscience and XXXII Annual Conference
of the Indian Academy of Neurosciences. p.127-128.
67. Nair, R.S., Chhaya, S., Pratap, U.P., Hima, L., Priyanka, H.P., and ThyagaRajan, S. (2014)
Correlative study of the role of spirituality on cancer-associated metabolic reprogramming and
cancer-related fatigue in Indian women with metastatic breast cancer. International Symposium
on Translational Neuroscience and XXXII Annual Conference of the Indian Academy of
Neurosciences. p.. 161.
68. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., and ThyagaRajan, S. (2014) Correlative
analysis of cognitive dysfunction and expression of amyloid precursor protein in Indian men
and women with Alzheimer’s disease. International Symposium on Translational Neuroscience
and XXXII Annual Conference of the Indian Academy of Neurosciences. p.162-163.
69. Gour, S., Hima, L., Pratap, U.P., Kannan, T., Patel, M., Vasantharekha, R., Priyanka, H.P., and
ThyagaRajan, S. (2014) Age-associated alterations in humoral immune functions and
antioxidant enzyme activities correlative with serum cortisol in the lymphocytes of healthy
Indian women. International Symposium on Translational Neuroscience and XXXII Annual
Conference of the Indian Academy of Neurosciences. p.178.
70. Kannan, T., Pratap, U.P., Hima, L., Gour, S., Patel, M., Nair, R.S., Vasantharekha, R.,
Priyanka, H.P., and ThyagaRajan, S. (2014) Aging alters cell mediated immune functions and
signaling pathways in lymphocytes of healthy Indian men correlative with serum cortisol .
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71. Pratap, U.P., Patil, A., Kale, P., Hima, L., Singh, R.V., Priyanka, H.P., and ThyagaRajan, S.
(2014) Estrogen modulates intracellular signaling pathways in Medial basal hypothalamus and
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Striatum of middle-aged ovariectomized female rats. International Symposium on Translational
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72. Priyanka, H.P., Pratap U.P., Hima L., ThyagaRajan S. (2014) β₂-adrenoceptor stimulation
differentially regulates breast cancer cell survival depending on estrogen receptor (ER) status
through p-ERK. Proceedings of International Conference on Cancer Biology: Molecular
Mechanisms and Novel Therapeutics, “Cancercon 2014, p.119.
73. Hima, L., Patel, M., Shaili, G., Kannan, T., Pratap, U.P., ThyagaRajan, S. (2015). Age-related
alterations in stress hormone, pro-inflammatory cytokines and antioxidant enzymes in healthy
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74. Pratap, U.P., Hima, L., Patil, A., Priyanka, H.P., ThyagaRajan, S. (2015). Effects of 17β-
estradiol on cholinesterase activity and tyrosine hydroxylase expression via p-ERK and p-Akt
pathways in frontal cortex of middle-aged ovariectomized rats. XXXIII Annual Conference of
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75. Chockalingam, R.M., Hariharan, M.M., Prasanna, V., Pratap, U.P., Hima, L., ThyagaRajan, S.
(2015). Differential modulation of activities of the metabolic enzymes by 17β-estradiol in the
brain areas of ovariectomized female Sprague-Dawley rats. XXXIII Annual Conference of
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76. Ravichandran, K. A., Karrunanithi S., Hima, L., Pratap, U. P., Priyanka, H.P. ThyagaRajan, S.
(2016). Upregulation of neural parameters, molecular mechanisms and antioxidant status
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(2016). Estrogen modulates neural factors, intracellular signalling molecules and antioxidant
status in thymus of middle-aged ovariectomized female Sprague-Dawley rats. Indian Academy
of Neurosciences-2016: 132-133.
78. Popat, D., Talapatra, A., Ravichandran, K. A., Hima, L, and ThyagaRajan, S. (2017). Virgin
coconut oil enhances antioxidant status in the thymus of female wistar rats through cell signaling
molecules. Indian Academy of Neurosciences-2017: P86.
79. Talapatra, A., Popat, D., Ravichandran, K. A., Hima, L, and ThyagaRajan, S. (2017). Virgin
Coconut Oil Enhances Intracellular Signaling Molecules and Antioxidant Enzyme Activities in
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Interactions occur in men compared to women through discrete intracellular signaling pathways.
International Conference on Immunology. P.No.79, September 2018.
81. Vasantharekha, R. and ThyagaRajan, S. Interaction of signaling and immune pathways in
Alzheimer’s disease. International Conference on Immunology. P.No.29, September 2018.
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82. Subramanian, P. A., Thandapani, P., Ananth, S., Vasantharekha, R. and ThyagaRajan, S.
Neuro-immune interactions in obesity. International Conference on Immunology. P.No.77,
September 2018.
83. Kumaraguru, S., Ramesh, A. P., Vasantharekha, R. and ThyagaRajan, S. Neuro-immune
interactions in cancer. International Conference on Immunology. P.No.78, September 2018.