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CURRICULUM VITAE REUBEN KAPUR, PH.D
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Reuben Kapur, Ph.D. - CV 07152013 1 CURRICULUM VITAE REUBEN KAPUR, PH.D. Freida and Albrecht Kipp Chair Professor of Pediatrics Director, Program in Hematologic Malignancies and Stem Cell Biology Professor of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Microbiology & Immunology Chairman, Biomedical Research Committee Herman B Wells Center for Pediatric Research Indiana University School of Medicine Cancer Research Institute 1044 W. Walnut Street, Room 168 Indianapolis, IN 46202 Phone: 317-274-4658 Fax: 317-274-8679 Email: [email protected] http://www.wellscenter.iupui.edu/researchers/reuben-kapur http://www.cancer.iu.edu/research/members/member_bio.php?id=1250 PROFILE Dr. Kapur is the Director of the Hematologic Malignancies and Stem Cell Biology Research Program within the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine. The group consists of six members including Drs. Mervin Yoder (endothelial cell biology and stem cell development), Nadia Carlesso (Notch signaling in stem cells and leukemogenesis), Rebecca Chan (SHP2 mutations in JMML), Mingjiang Xu (ASLX1 and TET2 mutations in leukemogenesis) and Yan Liu (Bmi1 signaling in stem cells and leukemogenesis). The group regularly interacts with other stem cell biologists on campus including Drs. Hal Broxmeyer (stem cell biology), Louis Pelus (stem cell homing and mobilization) and Edward Srour (hematopoietic microenvironment). Dr. Kapur is a principal investigator at the Wells Center focusing on understanding the molecular mechanisms of adhesion/migration and growth control in normal and leukemic stem/progenitor cells. He received his undergraduate degrees from Christ Church College (in Physics, Chemistry and Mathematics) and Washington State University (in Microbiology and Immunology). He obtained his Ph.D. from the University of Arizona, majoring in Microbiology and Immunology and minoring in Molecular and Cellular biology. He completed his post-doctoral fellowship under the supervision of Dr. David A. Williams at the Herman B Wells Center in the area of hematopoietic stem cell biology as a Howard Hughes Fellow and joined the pediatric faculty as an Assistant Professor in 2001. He was promoted to full Professor in 2010. Dr. Kapur has distinguished himself as an outstanding scientist in the area of Hematologic Malignancies and Hematopoietic Stem and Progenitor Cell Biology and has established a national and international reputation in this field. He has served on several important committees such as the American Society of Hematology (ASH), the International Society for Experimental Hematology (ISEH), and the National Institutes of Health (NIH) Hematopoiesis Study Section. Dr. Kapur continues
Transcript of CURRICULUM VITAE REUBEN KAPUR, PH.D
Reuben Kapur, Ph.D. - CV 07152013 1
CURRICULUM VITAE
REUBEN KAPUR, PH.D. Freida and Albrecht Kipp Chair Professor of Pediatrics Director, Program in Hematologic Malignancies and Stem Cell Biology Professor of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Microbiology & Immunology Chairman, Biomedical Research Committee Herman B Wells Center for Pediatric Research Indiana University School of Medicine Cancer Research Institute 1044 W. Walnut Street, Room 168 Indianapolis, IN 46202 Phone: 317-274-4658 Fax: 317-274-8679 Email: [email protected] http://www.wellscenter.iupui.edu/researchers/reuben-kapur http://www.cancer.iu.edu/research/members/member_bio.php?id=1250
PROFILE Dr. Kapur is the Director of the Hematologic Malignancies and Stem Cell Biology Research Program within the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine. The group consists of six members including Drs. Mervin Yoder (endothelial cell biology and stem cell development), Nadia Carlesso (Notch signaling in stem cells and leukemogenesis), Rebecca Chan (SHP2 mutations in JMML), Mingjiang Xu (ASLX1 and TET2 mutations in leukemogenesis) and Yan Liu (Bmi1 signaling in stem cells and leukemogenesis). The group regularly interacts with other stem cell biologists on campus including Drs. Hal Broxmeyer (stem cell biology), Louis Pelus (stem cell homing and mobilization) and Edward Srour (hematopoietic microenvironment). Dr. Kapur is a principal investigator at the Wells Center focusing on understanding the molecular mechanisms of adhesion/migration and growth control in normal and leukemic stem/progenitor cells. He received his undergraduate degrees from Christ Church College (in Physics, Chemistry and Mathematics) and Washington State University (in Microbiology and Immunology). He obtained his Ph.D. from the University of Arizona, majoring in Microbiology and Immunology and minoring in Molecular and Cellular biology. He completed his post-doctoral fellowship under the supervision of Dr. David A. Williams at the Herman B Wells Center in the area of hematopoietic stem cell biology as a Howard Hughes Fellow and joined the pediatric faculty as an Assistant Professor in 2001. He was promoted to full Professor in 2010. Dr. Kapur has distinguished himself as an outstanding scientist in the area of Hematologic Malignancies and Hematopoietic Stem and Progenitor Cell Biology and has established a national and international reputation in this field. He has served on several important committees such as the American Society of Hematology (ASH), the International Society for Experimental Hematology (ISEH), and the National Institutes of Health (NIH) Hematopoiesis Study Section. Dr. Kapur continues
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to publish in prestigious journals and holds multiple National Institutes of Health research grants in hematopoietic stem cell biology and leukemia. RESEARCH FOCUS Major focus of Dr. Kapur’s lab is to understand the signaling pathways involved in regulating normal and abnormal hematopoiesis. In adults, bone marrow (BM) is the major site for the continuous production of mature blood cells. Mature blood cells arise from hematopoietic stem cells (HSC) within the bone marrow cavity. While the regulation of HSCs is an extremely popular area of investigation, how it occurs remains an enigma. It is thought that part of the process involves self-renewal, differentiation and apoptosis or senescence. Although the precise mechanisms by which these fates are determined is still unclear, several molecules have been implicated in these processes, including components of the BM microenvironment. The BM microenvironment consists of extracellular matrix proteins as well as cells such as osteoblasts and stromal cells which contribute to hematopoietic stem/progenitor (HSC/P) cell fate by anchoring these cells in the BM cavity and delivering adhesive signals as well as signals in the form of soluble ligands, including cytokines and chemokines. These signals induce intracellular activation of both the positive regulators of HSC/P cell growth, self-renewal and differentiation as well as negative signals. Some of these pathways, such as those initiated by stem cell factor (SCF), the ligand for KIT, stromal cell derived factor-1 (SDF-1), and thrombopoietin (TPO), induce the activation of phosphatidylinositol-3 kinase (PI3K), Src kinase (SFK) and focal adhesion kinase (FAK). How PI3K and its downstream targets including members of Rho family GTPases including ROCK and Rap1 contribute to HSC/P regulation is a major area of ongoing research in Kapur's lab. Kapur lab is also interested in understanding the mechanisms of oxidative as well as ribosomal stress and has recently identified an essential role for FAK and ROCK kinases in this process. In the context of leukemogenesis, Kapur lab is interested in understanding the role of oncogenic forms of KIT and FLT3 receptors in regulating myeloproliferative neoplasms as well as acute myeloid leukemia, with the intent of defining novel therapeutic targets in these diseases. EDUCATION
UNDERGRADUATE: 1982-1985 Christ Church College, B.S. Physics, Chemistry & Mathematics 1985-1989 Washington State University, B.S. (Cum Laude), Microbiology & Immunology GRADUATE: 1989-1994 University of Arizona, Ph.D. Microbiology & Immunology w/Minor in Molecular and Cellular Biology POSTDOCTORAL: 1994-1997 Howard Hughes Fellow, Howard Hughes Medical Institute, Indiana University School of Medicine, Indianapolis, IN 1997-1998 Leukemia Research Foundation Fellow, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
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1998-1999 National Research Service Award (NIH/NRSA Fellow), Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
ACADEMIC APPOINTMENTS
1999-2002 Adjunct Graduate Faculty, Department of Life Sciences, School of Graduate Studies,
Indiana State University, Terre Haute, IN 1999-2001 Assistant Scientist, Herman B Wells Center for Pediatric Research, Indiana University
School of Medicine, Indianapolis, IN 2001-2006 Assistant Professor of Pediatrics, Herman B Wells Center for Pediatric Research,
Indiana University School of Medicine, Indianapolis, IN 2001-2006 Associate Member, Cancer Research Center, Indiana University School of Medicine,
Indianapolis, IN 2003-2006 Assistant Professor of Molecular Biology and Biochemistry, Indiana University School
of Medicine, Indianapolis, IN 2006-present Member, Cancer Research Center, Indiana University School of Medicine,
Indianapolis, IN 2007-2010 Associate Professor of Pediatrics, Herman B Wells Center for Pediatrics, Indiana
University School of Medicine, Indianapolis, IN 2007-2010 Associate Professor of Molecular Biology and Biochemistry, Medical and Molecular
Genetics, Indiana University School of Medicine, Indianapolis, IN 2007-2010 Associate Professor of Microbiology and Immunology, Indiana University School of
Medicine, Indianapolis, IN 2009-present Director, Hematologic Malignancies and Stem Cell Biology Program, Herman B Wells
Center for Pediatric Research, IU School of Medicine, Indianapolis, IN 2010-present Professor of Pediatrics, Herman B Wells Center for Pediatrics, Indiana University
School of Medicine, Indianapolis, IN 2010-present Professor of Molecular Biology and Biochemistry, Medical and Molecular Genetics,
Indiana University School of Medicine, Indianapolis, IN 2010-present Professor of Genetics, Indiana University School of Medicine, Indianapolis, IN 2010-present Professor of Microbiology and Immunology, Indiana University School of Medicine,
Indianapolis, IN 2010-present Freida and Albrecht Kipp Professor of Pediatrics, Department of Pediatrics, Indiana
University School of Medicine, Indianapolis, IN 2013 Chairman, Biomedical Research Committee, Indiana University School of Medicine,
Indianapolis, IN HONORS AND AWARDS
1989 Cum Laude, Washington State University 1989-1990 Graduate Academic Fellowship, University of Arizona 1991-1992 Outstanding Instructor, University of Arizona 1994-1997 Howard Hughes Postdoctoral Fellowship, Indiana University School of Medicine 1997-1998 Leukemia Research Foundation Fellowship, Indiana University School of Medicine 1998-1999 NIH Postdoctoral Fellowship (NRSA), Indiana University School of Medicine 2000-2002 Junior Faculty Scholar Award, American Society of Hematology (ASH) 2001 Travel Award, American Society of Hematology, Orlando, FL.
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2008 Prestigious External Award Recognition, 2008 IUPUI Chancellor’s Honors Convocation, Indianapolis, IN
2008 Invited faculty of 1000 Medicine 2013 Chairman, Biomedical Research Committee (BRC), Indiana University School of
Medicine, Indianapolis, IN 2013 Nominated, Vice President, International Society for Experimental Hematology TEACHING ASSIGNMENTS
1990-1994 Assistant Instructor, Microbiology and Immunology, University of Arizona UNDERGRADUATE SUMMER STUDENTS AND MEDICAL STUDENTS: 1990-1993 J. LoCascio, Selectide, Inc., Biotech firm 1990-1993 T. D. Camenisch, Assistant Professor, University of Arizona 1990-1994 J. Keifer, Graduate Student, University of Texas 1990-1992 A. Acevedo, Medical Student, University of Arizona 1995 J. Uffman, First Year Resident, University of Arizona 1996 K. Schindler, Graduate Student, University of Colorado 1995-1998 R. Maze, Patent Lawyer, Washington, DC 1995 D. McMillin, Undergraduate Student, Indiana University 1998 G. Chen, Residency, Vanderbilt University 1999-2010 Taught over 300 students in the “Molecular Medicine in Action” Program for High
School Students who are interested in pursuing a career in science 2002-2003 Philip Huang, Indiana University School of Medicine 2002-2003 J.T. Gripe, Indiana University School of Medicine 2002-2003 Margret Haineline, Indiana University School of Medicine 2002-2003 Brian Money, Indiana University School of Medicine 2004 Chad Harris, Indiana University School of Medicine 2005 Peter Kariuki, Indiana University School of Medicine 2006 Joel Beane, Indiana University School of Medicine 2007 Benjamin Abratigue, Indiana University School of Medicine 2008 Allison Rusie, Indiana University School of Medicine 2009 Jessica Arnett, Indiana University School of Medicine 2009 Stephen Spencer, Indiana University School of Medicine 2010-2012 Alexander Tuttle, Indiana University School of Medicine 2010-2012 Philip Hanneman, Indiana University School of Medicine 2011 Linlin Xu, Indiana University School of Medicine 2012-2013 Victor Canela, California State University, Dominguez Hills, CA 2012 Lisa Miele, Indiana University School of Medicine 2012-2013 Emily Waskow, Indiana University School of Medicine GRADUATE SCHOOL THESIS COMMITTEES: 2003-2008 Christopher Lux (MD/Ph.D.), Department of Biochemistry and Molecular Biology,
Indiana University School of Medicine 2005-2011 Elisabeth Lasater (Ph.D.), Department of Biochemistry and Molecular Biology, Indiana
University School of Medicine
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2006-2012 Sarah Nabinger (Ph.D.), Department of Medical and Molecular Genetics, Indiana University School of Medicine
2008-2011 Lisa Smith (Ph.D.), Department of Microbiology and Immunology, Indiana University School of Medicine
2010-2012 Hoa Nguyen (Ph.D.), Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
2010-present Brandon David Downing (MD/Ph.D.), Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
2010-2013 Jonathan Luke Meador (M.S.), Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
PH.D. THESIS DIRECTOR: 1999-2002 Saurabh Chandra, (Ph.D.), Indiana University School of Medicine 2005-2011 Subha Krishnan (Ph.D.), Department of Biochemistry and Molecular Biology, Indiana
University School of Medicine 2006-present Holly Martin (Ph.D.), Department of Medical and Molecular Genetics, Indiana
University School of Medicine 2009-present Joydeep Ghosh (Ph.D.), Microbiology and Immunology, Indiana University School of
Medicine POSTDOCTORAL FELLOWS: 2000-2003 Bailin Tan, M.D., Indiana University School of Medicine, now Associate Research
Professor at Indiana University, Indianapolis, IN 2001-2005 Li Hong, Ph.D., Indiana University School of Medicine, now Senior Scientist at Eli Lilly,
Indianapolis, IN 2002-2008 Veerendra Munugalavadla, Ph.D., Indiana University School of Medicine, now Senior
Scientist at Genetech, San Francisco, CA 2003-2006 Jinbiao Chen, Ph.D., Indiana University School of Medicine, now Senior Scientist at Eli
Lilly, Indianapolis, IN 2005-2011 Sasidhar Vemula, Ph.D., Indiana University School of Medicine - now Assistant
Research Professor, Indiana University School of Medicine, 2006-2012 Peilin Ma, Ph.D., Indiana University School of Medicine - now Assistant Research
Professor, University of Michigan 2006-present Baskar Ramdas, Ph.D., Indiana University School of Medicine 2006-present Ping Hu, Ph.D., Indiana University School of Medicine 2008-present Raghuveer Mali, Ph.D., Indiana University School of Medicine 2010-present Anindya Chatterjee, Ph.D., Indiana University School of Medicine AWARDS TO STUDENTS AND POSTDOCTORAL FELLOWS: 2001 Bailin Tan, (Postdoctoral Fellow) was awarded travel award to attend the annual
meeting of the American Society of Hematology, Orlando, FL 2001 Anita Reddy (Summer student) was awarded 2nd price for the work she accomplished
under the Wells Center summer student program, Indiana University School of Medicine
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2003 Veerendra Munugalavadla (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, San Diego, CA
2004 Veerendra Munugalavadla (Postdoctoral Fellow) was awarded first prize for his poster presentation at the “Biochemistry Research Day”, Indianapolis
2005 Jinbiao Chen (Postdoctoral Fellow) was awarded first prize for his poster presentation at the “Biochemistry Research Day”, Indianapolis
2005 Jinbiao Chen (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, Atlanta, GA
2007 Subha Krishnan (Graduate Student) was awarded a travel award to attend the Keystone Symposia, "PI3-Kinase Signaling Pathways in Disease", in Santa Fe, New Mexico.
2007 Veerendra Munugalavadla (Postdoctoral Fellow) was invited to speak at the Plenary Session, ISEH, Hamburg, Germany
2007 Peilin Ma (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, Atlanta, GA.
2007 Sasidhar Vemula (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, Atlanta, GA.
2007 Veerendra Munugalavadla (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, Atlanta, GA.
2008 Sasidhar Vemula (Postdoctoral Fellow) was invited to attend the American Association for Cancer Research-American Society of Hematology Workshop on PI3-Kinase, Lansdowne, VA.
2009 Sasidhar Vemula (Postdoctoral Fellow) was awarded a travel award to attend the annual meeting of the American Society of Hematology, New Orleans, LA.
2009 Raghuveer Mali (Postdoctoral Fellow) was awarded a travel award to attend the 51st Annual meeting of the American Society of Hematology, New Orleans, LA.
2010 Raghuveer Mali (Postdoctoral Fellow) was awarded the Transitional/Clinical Research; Post-Doc/Medical Fellow Poster Award. Indiana University Cancer Research Day, Indianapolis, IN
2010 Peilin Ma (Postdoctoral Fellow) was awarded the Basic Science; Post-Doc/Medical Fellow Poster Award, Indiana University Cancer Research Day, Indianapolis, IN
2010 Sasidhar Vemula (Postdoctoral Fellow) was awarded the Outstanding Poster Presentation Award, Midwest Blood Club Meeting, Indianapolis, IN.
2011 Anindya Chatterjee (Postdoctoral Fellow), Basic Sciences/Postdoc/Medical Student Award - 2nd Place, Indiana University Cancer Research Day, Indianapolis, IN
2011 Raghuveer Mali (Postdoctoral Fellow) was awarded a travel award to attend the 53rd Annual meeting of the American Society of Hematology, San Diego, CA
2011 Raghuveer Mali, Best Poster Award, 9th Annual Midwest Blood Club Symposium, Cincinnati, OH
2011 Holly Martin (graduate student), Paradise Award, 1st place at 2012 Sigma Xi Graduate Biomedical Research Competition, Indiana University School of Medicine, Indianapolis, IN
2011 Holly Martin (graduate student), Honorable Mention in the Translational/Clinical Research, IUSCC Cancer Research Day, Indiana University School of Medicine, Indianapolis, IN
2012 Holly Martin (graduate student), ST. Jude National Graduate Student Symposium Participant, Memphis, TN
2012 Holly Martin (graduate student), Poster Award, Graduate Student category, 10th Annual Midwest Blood Club, Indianapolis, IN
2012 Holly Martin (graduate student), Abstract Achievement Award, American Society of Hematology, Atlanta, GA.
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2013 Anindya Chatterjee (Postdoctoral Fellow), Presentation Award - 1st place, Indiana University Cancer Research Day, Indianapolis, IN
2013 Holly Martin (graduate student), Presentation Achievement Award, Indiana University Cancer Research Day, Indianapolis, IN
GRADUATE TEACHING ASSIGNMENTS: 2004-2007 Responsible for team teaching a graduate level course (B810) in the Department of
Molecular Biology and Biochemistry, Cellular Biochemistry and Regulation, Fall Term. 2005-2007 Responsible for team teaching a graduate level course (J854) in the Department of
Microbiology and Immunology, Hematopoiesis, Spring Term. PROFESSIONAL ORGANIZATIONS
1989-present Golden Key Honor Society, Washington State University 1989-present Phi Beta Kappa Society, Washington State University 1998-present Member, American Society of Hematology (ASH) 2001-present Member, Indiana University School of Medicine Cancer Center - NIH funded 2001-present Member, Indiana University School of Medicine Cancer Center - Core Centers for Excellence in Molecular Hematology - NIH funded 2001-present Member, International Society for Experimental Hematology (ISEH) 2003-present Member, American Society of Biochemistry and Molecular Biology 2009-present Member, American Society for the Advancement of Science (AAAS) PROFESSIONAL SERVICE
American Society of Hematology (ASH): 2000 Scientific Session Chair, American Society of Hematology (ASH), San Francisco, CA 2003 Abstract Reviewer, American Society of Hematology (ASH), San Diego, CA. 2003 Scientific Season Chair, Hematopoietic Stem and Progenitor Biology, American
Society of Hematology (ASH), San Diego, CA. 2005 Abstract Reviewer, American Society of Hematology (ASH), Atlanta, GA. 2005 Scientific Session Chair, Hematopoiesis-Cytokines and Signal Transduction, American
Society of Hematology (ASH), Atlanta, GA. 2008 Scientific Season Chair, Signaling Diversity in Hematopoietic Cells, American Society
of Hematology (ASH), San Francisco, CA 2008-2010 Member of American Society of Hematology (ASH) Scientific Committee on
Hematopoietic Cytokines and Factors 2009 Nominator of Abstract Reviewer for the American Society of Hematology (ASH) 2009,
New Orleans, LA 2010 Abstract Reviewer, American Society of Hematology (ASH) Scholar Awards Study
Section 2011 Abstract Reviewer, American Society of Hematology (ASH), San Francisco, CA. 2012 Coordinating Chair for Abstract Reviews, American Society of Hematology (ASH),
Atlanta, GA
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Department of Defense (DOD): 2008 Scientist Reviewer, NFRP Neurofibromatosis-B 2009 Scientist Reviewer, PRMRP Peer Reviewed Medical Research 2012 Scientist Reviewer, NFRP Molecular Biology International Society of Experimental Hematology (ISEH): 2006-present Member of Editorial Board, Journal of Experimental Hematology 2008 Abstract Reviewer, International Society for Hematology and Stem Cells (ISEH),
Boston, MA 2008-2010 Secretary/Treasurer, International Society of Experimental Hematology (ISEH) Board
of Directors 2013 Nominated, Vice President International Society of Experimental Hematology (ISEH) Midwest Blood Club (MWBC): 2007 Scientific Season Chair, “Midwest Blood Club”, Cincinnati’s Children’s Hospital Medical
Center, Cincinnati, OH National Institutes of Health (NIH): 2005 Ad-Hoc Reviewer, Heart, Lung, and Blood Program Project Review Committee (HLBP) 2006 Ad-Hoc Reviewer, Hematopoiesis (HP) study section 2006 Ad-Hoc Reviewer, Hematopoiesis (HP) study section 2007 Ad-Hoc Reviewer, Red cell membrane studies, ZDK1-GRB-G (M2) 2007 Ad-Hoc Reviewer, Hematopoiesis (HP) study section 2008 Ad-Hoc Reviewer, Hematology Program Projects, ZDK1-GRB-9 (M2) 2008 Ad-Hoc Reviewer, Heart, Lung, and Blood Program Project Review Committee (HLBP) 2008 Standing member, Hematopoiesis (HP) study section 2008 Ad-Hoc Reviewer, R13 conference application, ZDK1-GRB-N (J2) 2009 Standing member, Hematopoiesis (HP) study section 2009 Ad-Hoc Reviewer, Heart, Lung, and Blood Program Project Review Committee (HLBP) 2009 Standing member, Hematopoiesis (HP) study section 2009 Ad-Hoc Reviewer, NHLBI Grand Opportunities in Translational Research
Implementation Program (ARRA), ZHL1-CSR-H (O2) 2009 Standing member, Hematopoiesis (HP) study section 2010 Standing member, Hematopoiesis (HP) study section 2010 Ad-Hoc Reviewer, Center for Scientific Review special emphasis panel, ZRG1-MCH-G 2010 Standing member, Molecular and Cellular Hematology (MCH) Study Section 2010 Standing member, Molecular and Cellular Hematology (MCH) Study Section 2011 Standing member, Molecular and Cellular Hematology (MCH) Study Section 2011 Standing member, Molecular and Cellular Hematology (MCH) Study Section 2011 Ad-Hoc Reviewer, Molecular Oncogenesis (MONC) Study Section 2011 Ad-Hoc Reviewer, R13 conference application, ZDK1-GRB-N (M4) 2012 Ad-Hoc Reviewer, Cellular and Molecular Immunology-B (CMIB) Study Section 2013 Ad-Hoc Reviewer, R13 conference application, ZDK1-GRB-N (M3) 2013 Ad-Hoc Reviewer, Molecular Oncogenesis (MONC) Study Section
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2013 Ad-Hoc Reviewer, Member Conflict, Hematology and Vascular Pathobiology, ZRG1-VH-D (03)
Other: 2006 Ad-Hoc Reviewer, Italian Association for Cancer Research 2006-present Ad-Hoc Reviewer, Ohio Cancer Research Associates 2007 Ad-Hoc Reviewer, Vienna Science and Technology Fund, Austria 2009-present Member, Board of Directors, Indiana Cord Blood Bank, Indianapolis, IN 2013 Ad-Hoc Reviewer, Israel Science Foundation
REVIEWER FOR JOURNALS: 2000-present Blood Journal 2001-present Journal of Leukocyte Biology 2002-present Leukemia 2002-present Journal of Experimental Hematology 2002-present Oncogene 2004-present Stem Cells 2004-present International Journal of Biochemistry and Cell Biology 2004-present Molecular and Cellular Biology 2005-present Genes and Development 2005-present European Journal of Biochemistry 2006-present European Journal of Hematology 2008-present Journal of Clinical Investigation 2008-present Journal of Immunology 2008-present Cancer Research 2006-present Immunity 2006-present American Journal of Pathology UNIVERSITY SERVICE
1999-2007 Teacher, “Molecular Medicine in Action (MMIA)”, A Science Symposium for High
School Students, Indiana University School of Medicine 2000 Judge, Graduate Student Symposium, Indiana University School of Medicine 2002-2004 Responsible for organizing weekly Seminar Series in Herman B Wells Center 2003 Poster Judge, Research Day, Indiana University, Cancer Center 2004-present Member, Biomedical Research Committee, Indiana University School of Medicine.
Responsible for reviewing ~50 grant applications per year. 2004-2010 Member, LARC Advisory Committee, Indiana University School of Medicine 2005-2011 Member, Search Committee for recruiting Principal Investigator’s in the Pulmonary
Research Division of Wells Center, Indiana University School of Medicine 2005-2007 Member, Graduate Student Admissions Committee for the Department of Molecular
Biology and Biochemistry 2006 Judge/Member, Graduate Student Symposium, Indiana University School of Medicine 2006 Poster Judge, Research Day, Indiana University Cancer Center
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2006-present Member, Graduate Student Admissions Committee (IBMG), Indiana University-Purdue University at Indianapolis. Responsible for reviewing ~100 applicants a year and making overseas trips for interviewing and recruiting foreign graduate students to the IBMG program.
2007-2009 Member, Search Committee for recruiting Principal Investigators in the Department of Molecular Biology and Biochemistry, Indiana University School of Medicine
2008-present Member, In Vivo Therapeutics Core Advisory Committee 2009-present Member, Recruitment of M.D./Ph.D. Students, Indiana University School of Medicine 2010-2012 Co-Chair, Biomedical Research Committee, Indiana University School of Medicine 2012 Member, Riley Hospital Committee Meeting (Giving Campaign) 2012-present Chairman, Biomedical Research Committee (BRG), Indiana University School of
Medicine, Indianapolis, IN OTHER PROFESSIONAL ACTIVITIES
PRESENTATIONS/LECTURES/SEMINARS: 2000 Keystone Symposia, Breckenridge, CO 2000 American Society of Hematology (ASH), San Francisco, CA 2001 American Society of Hematology (ASH), Orlando, FL 2001 Department of Experimental Hematology, University of Cincinnati, Children’s Hospital,
Cincinnati, OH 2002 Department of Biology, Ball State University, Muncie, IN 2003 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 2003 Department of Molecular Biology and Biochemistry, Indiana University School of
Medicine, Indianapolis, IN 2003 American Society of Hematology (ASH), San Diego, CA 2005 “Activating mutations of KIT in hematopoiesis”, John’s Hopkins University, Baltimore,
MD 2005 “Activating mutations of KIT in hematopoiesis”, Wabash College, Crawfordsville, IN 2006 “Role of KIT in Hematopoiesis”, Queens University, Ontario, Canada 2006 “Role of Oncogenic KIT in Mastocytosis”, Workshop on Myeloid Development,
American Society for Hematology (ASH), Orlando, FL 2007 “Role of Src and PI3Kinase in Hematopoiesis”, Department of Experimental
Hematology, Cincinnati’s Children’s Hospital Medical Center, Cincinnati, OH. 2007 “Role of PI3Kinase in Normal and Abnormal Hematopoiesis”, Department of Medical &
Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 2007 “Role of PI3Kinase in Leukemogenesis”, Department of Microbiology and Immunology,
Indiana University school of Medicine, Indianapolis, IN 2007 “Role of PI3Kinase in Hematopoiesis”, Division of Hematology/Oncology, Case
Comprehensive Cancer Center at the University Hospitals of Cleveland and Case Western Reserve University, CCCC Blood Club, Cleveland, OH
2008 “Role of PI3Kinase in Hematopoiesis”, University of New Mexico Cancer Center, Albuquerque, NM
2009 “Role of PI3 Kinase and Rho GTPase in Leukemogenesis”, Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY
2009 “Rock ‘n’ Roll in hematopoiesis”, Pediatric Faculty Research Seminar, Wells Center Seminar Series, Indiana University, Indianapolis, IN
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2011 “KIT induced myeloproliferative disease is dependent on PI3K and SHP2 phosphatase: identification of SHP2 as a novel druggable target for treating MPD and AML”, Midwest Blood Club, Cincinnati, OH
2012 “Targeting receptor tyrosine kinase signals in myeloproliferative neoplasms and AML”, Blood Center of Wisconsin, University of Wisconsin, Milwaukee, WI
2012 “Shp2 Breakthrough”, WFHB FireHouse Broadcasting, radio interview concerning Cancer Therapy, Bloomington Community Radio, Inc., Indianapolis, IN
2012 “Targeting oncogenic receptor tyrosine kinase induced signals in myeloproliferative neoplasms and acute myeloid leukemia”. Cardiac Group, Indiana University School of Medicine, Indianapolis, IN.
2012 “Targeting oncogenic receptor tyrosine kinase induced signals in myeloproliferative neoplasms and acute myeloid leukemia”. Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN.
2012 “Targeting oncogenic receptor tyrosine kinase induced signals in myeloproliferative neoplasms and acute myeloid leukemia”. Emory University, Winship Cancer Institute, Atlanta, GA.
2012 “Role of Rap GTPases in stem cell retention, engraftment and niche creation”. Workshop on Myeloid Development, American Society for Hematology, Atlanta, GA.
2013 “RAP “n” ROCK in hematopoiesis”, Department of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA.
2013 “Targeting oncogenic receptor tyrosine kinase induced signals in myeloproliferative neoplasms and acute myeloid leukemia”. Children’s Cancer Hospital, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
PATENTS
2003 Methods for Modulating the Proliferation of Hematopoietic cells by Fibronectin Peptides 2010 Rho Kinase Inhibitors as Potential Therapeutic Agents for Oncogenic KIT, FLT3, and
BCR-ABL Induced Leukemogenisis (Pending) 2012 Inhibition of ROCK1 for the Treatment of Anemia (Pending) 2012 Role of Rap1 in Stem Cell Engraftment (Pending) GRANTS AND FELLOWSHIPS
PRIOR SUPPORT: 1994-1997 Howard Hughes Fellowship, Indiana University School of Medicine 1997-1998 Leukemia Research Foundation, Indiana University School of Medicine 1997-2000 (NIH) NRSA F32 DK09752
National Institutes of Health The role of soluble and membrane-associated stem cell factor in hematopoiesis
2000-2002 American Society of Hematology (ASH) Junior Faculty Scholar Award
Functional and biochemical analysis of adhesion induced “cross-talk” between c-Kit and integrins
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2003-2004 Indiana University Core Centers of Excellence in Molecular Hematology NIH
“The role of PI-3Kinase in CML” 2004-2009 NIH R01 HL075816 (Kapur - PI) “Mechanisms of adhesion and growth control in stem cells”. 2005-2010 NIH R01 HL082981 (Kapur - Co-PI) “Activating PTPN11 and c-KIT mutations in Myeloproliferate disorder”. 2006-2012 NIH R01 HL077177 (Kapur - PI) “Novel mechanisms of c-KIT regulation in Mast cells”. 2009-2011 NIH-ARRA R01 HL079816 (Kapur - PI) “Mechanisms of adhesion and growth control in stem cells”.
CURRENT SUPPORT: 2009-2014 NIH R01 HL08111 (Kapur - PI) “Role of Vav and Rac in KIT oncogenesis” 2010-2015 NIH R01 CA134777 (Kapur/Chan - MPI) “Role of Shp2 in FLT3-ITD-Induced Leukemogenesis” 2011-2015 NIH R01 HL109602 (Kapur - Co-PI) “Collagen Cross-links Direct Matrix-Induced Vasculogenesis via Tunable Pathways” PENDING SUPPORT: R01 HL077177 (Kapur - PI) NIH/NHLBI “Novel Mechanisms of C-Kit Regulation in Mast Cells” 1R01CA171769 (Kapur - PI) NIH/NCI “Role of Rho kinases in chronic myelogenous leukemia” 1R01DK101009 (Kapur - PI) NIH/NIDDK “Signaling mechanisms involved in stress erythropoiesis” 1R01CA173852 (Kapur - PI) NIH/NCI “Role of p21 activated kinase in Leukemogenesis” 1R01HL118718 (Kapur - PI) NIH/NHLBI
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“Hyperactive Shp2 function in Myeloproliferative Neoplasms” 1R01CA171793 (Kapur - PI) NIH/NCI “Novel Signaling Mechanisms in Myeloproliferative Neoplasms” GRANTS AND FELLOWSHIPS TO GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS: T32 HL007910 (PI: Broxmeyer) (Kapur - Mentor) 12/01/07 - 11/30/12 NIH/NHLBI “Gene Therapy Training Grant”. Training program for post-doctoral fellows (Ping Hu, Ph.D and Anindya Chatterjee, Ph.D). T32 DK007519-26 (PI: Broxmeyer) (Kapur - Mentor) 07/01/07 - 12/31/2011 NIH/NIDDK “Regulation of Hematopoietic Cell Production”. Training program for graduate student (Holly Martin). 1F31AG040974 (PI: Martin; Kapur – Mentor) 01/01/12 – 12/13/2013 NIH/NIA “Novel therapeutic targets for Leukemia in Elderly” PF-13-065-01 (PI: Chatterjee; Kapur – Mentor) 01/01/13 – 01/01/2016 American Cancer Society (ACS) “A Novel FAK-Rac-PAK Signaling Pathway in Flt3ITD Induced Leukemogenesis” Biomedical Research Grant (PI: Mali; Kapur – Mentor) 07/01/13 - 06/30/2014 “Role of Lim Kinase in leukemogenesis” Ralph W. and Grace M. Showalter Research Trust (PI: Mali; Kapur - Mentor) 07/01/12 - 06/30/2013 “Ezrin’s role in chronic myelogenous leukemia” PUBLICATIONS
BOOK CHAPTERS: 1. Harris DT and Kapur R. Molecular characterization of a novel evolutionary conserved function-
associated molecule on natural killer cells. "Modulators of Immune Responses: The Evolutionary Trail", pp 167-182. SOS Publications, 1996.
2. Kapur R, Yoder MC, Polin RA: Developmental immunology, in AA Fanaroff, RJ Martin (eds):
Neonatal-Perinatal Medicine: Diseases of the fetus and infant, Seventh Edition, St. Louis, Mosby - Year Book, 2000, pp. 676-706.
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3. Douglas SD, Kapur R, Merrill JD, Yoder MC, Ho W: The Mononuclear Phagocytic, Dendritic cell, and Natural Killer Cell Systems, In Steihm ER, Ochs HD, Winkelstein JA, eds. Immunologic Disorders in Infants and Children, 5th ed., Harcourt, Philadelphia, 2004, pp.129-156
4. Reuben Kapur, Mervin C. Yoder, and Richard A. Polin. The Immune System. Fanaroff and
Martin's Neonatal-Perinatal Medicine, Diseases of the Fetus and Infant, 8th Edition, Volume 2, Mosby Elsevier, 2006, pp 761-882
5. Reuben Kapur, Mervin C. Yoder, and Richard A. Polin. The Immune System. Fanaroff and
Martin's Neonatal-Perinatal Medicine, Diseases of the Fetus and Infant, 9th Edition, Mosby Elsevier, June 2009
JOURNAL ARTICLES (PEER REVIEWED): 1. Harris DT., Kapur R, Frye C, Acevedo A, Camenisch T, Jaso-Friedmann L and Evans DL. A
species-conserved NK cell antigen receptor is a novel vimentin-like molecule. Dev. Comp. Immunology, (5):395-403, 1992.
2. Kapur R, Evans D, and Harris DT. Evolutionary conservation of human function-associated
molecule on murine natural killer cells: Expression and function. Scandinavian Journal of Immunology, 40(1):50-56, 1994.
3. Kapur R, Evans D, and Harris DT. An Evolutionary conserved target cell antigen along with MHC
class I molecules influences susceptibility to murine NK cell lysis. Dev. Comp. Immunology, (4):347-355, 1995.
4. Majumdar MK, Everett ET, Xiao X, Cooper R, Langley K, Kapur R, Vik T, and Williams DA.
Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations. Blood, Apr 15; 87(8):3203-3211, 1996.
5. Maze R, Kapur R, Kelley MR, Hansen WK, Oh SY, Williams DA. Reversal of 1, 3-bis (2-chloroethyl1)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using 06-methylguanine DNA methyltransferase complementary DNA. J Immunol, Jan 15;158(2):1006-1013, 1997.
6. Kapur R, Everett ET, McAndrews-Hill M, Vik T, and Williams DA. Overexpression of human stem
cell factor impairs melanocyte, mast cell, and thymocyte development: a role for receptor tyrosine kinase mediated MAP kinase activation in cell differentiation. Blood, Oct 15; 90 (8):3018-3026, 1997.
7. Kapur R, Majumdar MK, Xiao X, Schindler K, McAndrews-Hill M, and Williams DA. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis. Blood, Feb 1; 91(3):879-889, 1998.
8. Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock J, Borneo JB,
Bradford GB, Atkinson SJ, Dinauer MC, and Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity, Feb; (2):183-196, 1999.
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9. Kapur R, Cooper R, Xiao X, Donovan P, Weiss M, and Williams DA. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel (17H) mice. Blood, Sep 15; 94 (6):1915-1925, 1999.
10. Yang FC, Kapur R, King AJ, Tao W, Breese R, Marshall M, Dinauer MC, and Williams DA. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity, May; (5):557-568, 2000.
11. Kapur R, and Zhang L. A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin. J Biol Chem., Jan 1; 276 (2):1099-1106, 2001.
12. Kapur R, Cooper R, Zhang L, and Williams DA. Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways. Blood, Apr 1; 97 (7):1975-1981, 2001.
13. Marques SA, Dy LC, Southhall MD, Yi Q, Smietana E, Kapur R, Marques M, Travers JB, and
Spandau DF. The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway. J Pharmacol Exp Ther., Mar; 300(3):1026-1035, 2002.
14. Kapur R, Chandra SC, Cooper R, McCarthy J, and Williams DA. Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor. Blood, Aug 15; 100(4):1287-1293, 2002.
15. Ingram D, Zhang L, McCarthy J, Wenning MJ, Fisher L, Clapp DW, and Kapur R.
Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function. Blood, Nov 15; 100(10):3656-3662, 2002.
16. Xie X, Chan RJ, Johnson SA, Starr M, McCarthy J, Kapur R, and Yoder MC. Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs. Blood, Feb 15; 101(4):1329-1335, 2003.
17. Tan BL, Hong L, Munugalavadla V, and Kapur R. Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor. J Biol Chem., Mar 28; 278(13):11686-11695, 2003.
18. Tan BL, Yazicioglu MN, Ingram DA, McCarthy J, Borneo J, Williams DA, and Kapur R. Genetic evidence for convergence of c-Kit and alpha4 integrin-mediated signals on class IA PI-3Kinase and Rac pathway in regulating integrin-directed migration in mast cells. Blood, Jun 15; 101(12):4725-4732, 2003.
19. Huddleston H, Tan B, Yang FC, Wenning MJ, Orazi A, Yoder MC, Kapur R, and Ingram DA. Functional p85alpha gene is required for normal murine fetal erythropoiesis. Blood, Jul 1; 102(1):142-145, 2003.
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20. Chandra S, Kapur R, Chuzhanoya N, Summey V, Prentice D, Barker J, Cooper DN, and Williams
DA. A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype. Blood, Nov 15; 102(10):3548-55, 2003. (Chosen for the cover of November 15th, 2003 issue of the Journal Blood.)
21. Yang FC, Ingram DA, Chen S, Hingtgen CM, Ratner N, Monk KR, Clegg T, White H, Mead L, Wenning MJ, Williams DA, Kapur R, Atkinson SJ, and Clapp, DW. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1 +/- mast cells. J Clin Invest., Dec; 12(12):1851-1861, 2003.
22. Hong L, Munugalavadla V, and Kapur R. c-Kit mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways. Mol Cell Biol., Feb; 24 (3):1401-1410, 2004. PMCID: PMC321438
23. Hiatt K, Ingram DA, Huddleston H, Spandau DF, Kapur R, and Clapp DW. Loss of nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol., Apr;164(4):1471-1479, 2004.
24. Munugalavadla V, and Kapur R. Role of c-Kit and erythropoietin receptor in erythropoiesis. Crit Rev Oncol Hematol., Apr; 54(1):63-75, 2005.
25. Khalaf WF, White H, Wenning MJ, Orazi A, Kapur R, and Ingram DA. K-Ras is essential for normal fetal liver erythropoiesis. Blood, May 1; 105(9):3538-3541, 2005.
26. Chan RJ, Leedy MB, Munugalavadla V, Voorhorst CS, Li Y, Yu M, and Kapur R. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood, May 1; 105(9):3737-3742, 2005. PMCID: PMC1895012
27. Munugalavadla V, Bornew J, Ingram DA, and Kapur R. p85 Subunit of class IA PI-3Kinase is crucial for macrophage growth and migration. Blood, Jul 1; 106:103-109, 2005. PMCID: PMC1895121
28. Munugalavadla V, Dore LC, Tan BL, Hong L, Vishnu M, Weiss MJ, and Kapur R. Repression of c-Kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Mol Cell Biol., Aug; 25(15):6747-6759, 2005. PMCID: PMC1190349
29. Bijangi-Vishehsaraei K, Saadatzadeh MR, Werne A, McKenzie K, Kapur R, Ichijo H, Haneline LS.
Enhanced TNF induced apoptosis in Fanconi anemia type C deficient cells is dependent on apoptosis signal-regulating kinase 1. Blood, Dec 15; 106(13):4124-4130, 2005. PMCID: PMC1895245
30. Wang ZY, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz RR, Dent AL. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J Immunol., Jan 15;176(2):880-888, 2006.
31. Haneline LS, White H, Yang FC, Chen S, Orschell C, Kapur R, Ingram DA. Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo. Blood, Feb 15; 107(4):1375-1382, 2006. PMCID: PMC1895408
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32. Li B, Jia N, Kapur R, Chun KT. Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood, Jun 1; 107(11):4291-4299, 2006. PMCID: PMC1895787
33. Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH. T-bet is a Critical Determinant in the Instability of the IL-17-Secreting T-helper Phenotype. Blood. Sep 1;108(5):1595-601, 2006. PMCID: PMC1895507
34. Wu X, Estwick SA, Ming W, Chen S, Nebesio T, Li Y, Yuan J, Kapur R, Ingram DA, Yoder MC,
Yang FC. Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem cell/progenitors. Hum Mol Genet. Oct 1;15(19):2837-45, 2006.
35. Mathur AN, Chang NC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas
GS, and Kaplan MH. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol. Apr 15; 178(8):4901-7, 2007.
36. Samayawardhena LA, Kapur R, Craig AW. Involvement of Fyn kinase in Kit and integrin-
mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood. May 1; 109(9):3679-86, 2007.
37. Borneo J, Munugalavadla V, Sims EC, Vemula S, Orschell CM, Yoder MC, and Kapur R. Src Family kinase mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors. Exp Hematol. Jul; 35(7):1026-37, 2007. PMCID: PMC2481405
38. Thieu VT, Nguyen ET, McCarthy BP, Bruns HA, Kapur R, Chang CH and Kaplan MH. IL-4 stimulated NF-КB activity is required for Stat6 DNA binding. J Leuk Biol. Aug; 82(2):370-9, 2007.
39. Munugalavadla V, Sims EC, Borneo J, Chan RJ and Kapur R. Genetic and Pharmacologic
Evidence Implicating the p85α, but not p85β, Regulatory Subunit of PI3K and Rac2 GTPase in Regulating Oncogenic KIT-Induced Transformation in Acute Myeloid Leukemia and systemic Mastocytosis. Blood. Sep 1:110(5):1612-20, 2007. PMCID: PMC1975845
40. Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW, Paranavitana NC, Peng X, Kim
C, Munugalavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J. Immunol. Dec 15; 178(12):8322-31, 2007. PMCID: PMC2722108
41. Munugalavadla V, Sims EC, Chan RJ, Lenz SD, and Kapur R. Requirement for p85α regulatory subunit of class IA PI3Kinase in myeloproliferative disease driven by an activation loop mutant of KIT. Exp Hematol. Mar; 36(3):301-8, 2008.
42. Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, Yuan J, Robling AG, Kapur R, Chan RJ, and Yang FC. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Hum Mol Genet. Apr 1; 17(7):936-48, 2008.
43. Orschell CM, Borneo J, Munugalavadla V, Ma P, Sims E, Ramdas B, Yoder MC, and Kapur R.
Deficiency of Src Family Kinases Compromises the Repopulating Ability of Hematopoietic Stem Cells. Exp Hematol. May; 36(5):655-66, 2008.
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44. Hong L, Ramdas B, Chen J, Harris C, Wojchowski DM, Kapur R. Kit associated intracellular tyrosines play an essential role in EpoR co-signaling. Cell Signal. Aug 20(8):1513-21, 2008. PMCID: PMC2666019
45. Munugalavadla V, Vemula S, Sims EC, Krishnan S, Chen S, Yan J, Li H, Niziolek PJ, Takemoto
C, Robling A, Yang FC, and Kapur R. The p85 Subunit of Class of IA Phosphatidylinositol 3Kinase Regulates the Expression of Multiple Genes Involved in Osteoclast Maturation and Migration. Molecular and Cellular Biology. December 28(23):7182-98, 2008. (Chosen for the cover of December 28th 2008 issue of the Journal Molecular and Cellular Biology.) PMCID: PMC2593377
46. Saadatzadeh MR, Bijangi-Vishehsaraei K, Kapur R, Haneline LS. Distinct roles of stress-
activated protein kinases in Fanconi anemia type C deficient hematopoiesis. Blood. Mar 19; 113(12):2655-60, 2009. PMCID: PMC2661855
47. Benson EA, Goebel MG, Yang FC, Kapur R, McClintick J, Sanghani S, Clapp DW, Harrrington
MA. Loss of SIMP compromises TNFα Dependent Survival of Hamatopoietic Progenitors. Ex. Hematol. Feb;38(2):71-81, 2010. PMCID: PMC2815193
48. Vemula S, Shi J, Hanneman P, Wei Lei, and Kapur R. ROCK1 Functions as a Suppressor of
Inflammatory Cell Migration by Regulating PTEN Phosphorylation and Stability. Blood. Mar 4;115(9):1785-96, 2010. PMCID: PMC2832812
49. Lasater EA, Li F, Bessler WK, Estes ML, Vemula S, Hingtgen CM, Dinauer M, Kapur R, Conway
SJ, and Ingram DA. Genetic and Cellular Evidence of Vascular Inflammation in Neurofibromin Deficient Mice and Humans. J Clin Invest. Mar 1;120(3):859-70, 2010. PMCID: PMC2593377
50. Vemula S., Ramdas B, Hanneman P, Martin J, Beggs HE, and Kapur R. Essential Role for Focal
Adhesion Kinase in Regulating Stress Hematopoiesis. Blood. Nov 18; 116 (20):4103-15, 2010. PMCID: PMC2993618
51. Lee Y; Brandal S; Noel P; Wentzel E; Mendell JT; McDevitt MA; Kapur R; Carter M; Metcalfe DD.
KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation. Blood. Mar 31; 117(13):3629-40, 2011. PMCID: PMC3072881
52. Wu X, Chen S, Orlando SA, Yuan J, Kim ET, Munugalavadla V, Mali RS, Kapur R, and Yang FC. p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway. J Biol Chem. Apr 15;286(15):13512-21, 2011. PMCID: PMC3075697
53. Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan
RJ, Krystal G, Craig AW, Takemoto C, and Kapur R. The PI3K pathway drives the maturation of mast cells via microphthaimia transcription factor. Blood. Sep 29;118(13):3459-69, 2011. PMCID: PMC3186328. (Plenary Paper).
54. Mali R, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC,
Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS and Kapur R. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL. Cancer Cell. Sep 13;20(3):357-69, 2011. PMCID: PMC32207244.
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Comment on this article - “ROCKing in hematology”. Science-Business Exchange - Nature Publishing Group, Martz L, SciBX 4(39);1081, 2011
Evaluated by Olson M, a member of faculty of 1000 (F1000): “The essential contribution of Rho kinase (ROCK) activity to the survival and growth of hematopoietic…..”. F1000.com/13293959.
Patent application filed in the US for the use of fasudil to treat mastocytosis and AML. SciBX 4(38); 1074, 2011
55. Ma P, Vemula S, Munugalavadla V, Chen JB, Sims E, Borneo J, Kondo T, Ramsas B, Mali RS, Li
S, Hashino E, Takemoto C, and Kapur R. Balanced Interactions between Lyn, p85α regulatory Subunit of Class IA Phosphatidylinositol-3-kinase and SHIP is Essential for Mast Cell Growth and Maturation. Molecular and Cellular Biology. Oct;31(19):4052-62. 2011. PMCID: PMC3187372.
56. Qu P, Yan C, Blum JS, Kapur R and Du H. Myeloid-specific expression of human lysosomal acid
lipase corrects malformation and malfunction of myeloid-derived suppressive cells in lal-/- mice. J of Immunology. Oct 1;187(7):3854-66, 2011. PMCID:PMC3178672
57. Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Famdas B, Ma P, Hasnino E,
and Kapur R. Class I(A) PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through regulation of Growth and survival Related Genes. PLoS One. 7(1):e28979, 2012. Epub Jan 4, 2012. PMCID: PMC3251560
58. Ma P, Mali RS, Martin H, Ramdas B, Sims E, and Kapur R. Role of intracellular tyrosines in
activating KIT induced myeloproliferative disease. Leukemia. Feb 2.doi:10.1038/leu.2012, 2012. PMCID: in process
59. Wu L, Yan C, Czader M, Foreman O, Blum JS, Kapur R, and Du H. Inhibition of PPARγ in
myeloid lineage cells induces systemic inflammation, ummunosuppression and tumorigenesis. Blood. Jan 5;119(1):115-26, 2012. PMCID: PMC3251224.
60. Ruschmann J, Antignano F, Lam V, Shyder K, Kim C, Essak M, Zhang A, Lin AH, Mali RS, Kapur
R, and Krystal G. The Role of SHIP in the Development and Activation of mouse Mocosal and Connective Tissue Mast Cells. J of Immunology. Apr 15;118(8):3839-50, 2012. PMCID: in process
61. Krishnan S, Mali RS, Ramdas B, Sims E, Ma P, Ghosh J, Munugalavadla V, Hanneman P, Beane
J, and Kapur R. p85β regulatory subunit of class IA PI3Kinase negatively regulates mast cell trowth, matruation and leukemogenesis. Blood. Apr 26;119(17):3951-61, 2012. PMCID: PMC3350362
62. Hu P, Carlesso N, Xu M, Liu Y, Nebreda AR, Takemoto C, and Kapur R. Genetic evidence for
critical roles of P38α in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J of Biol. Chem. Jun 8;287(24):20258-69, 2012. PMCID: PMC3370208
63. Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann
K, Roers A, and Craig AW. SH2 domain-containing phosphatase-2 is a critical regulator of connective tissue mast cell survival and nomeostasis in mice. Molecular and Cellular Biology. Jul;32(14):2653-63, 2012. PMCID: PMC3416204
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64. Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, and Kapur R. Role of SHP2 phosphatase in KIT induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. Sep 27;120 (13):2669-78, 2012. PMCID: PMC3460688.
Comment on the article - “KIT’s ship comes in” by Benjamin S. Braun, San
Francisco, University of California. Blood. 120,2541-2542, 2012
65. Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis T, An WF, Li
X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, VerPlank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner, J, Goh BC, Mercher T, Carpenter AE, Could RJ, Clemons PA, Carr SA , Root DE, Schreiber SL, Stern AM, and Crispino JD. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell. Aug 3;150 (3):575-89, 2012.
66. Vemula S, Shi J, Mali RS, Ma P, Liu Y, Hanneman P, Koehler KR, Hashino E, Wei L, and Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Blood. Oct 4;120(14):2868-76.doi:10.1182/blood-2011-10-384172, 2012. PMCID: PMC3466968
67. Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, and Brutkiewicz RR. Regulation of the actin cytoskeleton by Rho Kinase controls antigen presentation by CD1d1. J. of Immunology. Aug 15;198 (4):1689-98, 2012. PMCID: PMC3411863
68. Traina F, Jankowska AM, Visconte V, Makishima H, O’Keefe CL, Elson P, Han Y, Hsieh FH,
Sekeres MA, Kalaycio M, Lichtin AE, Advani AS, Duong HK, Copelan E, Kapur R, Saad STO, Maciejeski JP, and Tiu R. Single nucleotide polymorphism array leisions, TET2, DNMT3A, ASCL1 and CBL mutations are present in systemic mastocytosis. PlosOne . 7(8):e43090, 2012. PMCID: PMC3419680
69. Hu P, Nebreda AR, Liu Y, Carlesso N, Kaplan M, and Kapur R. P38α negatively regulates T helper type 2 responses by orchestrating multiple TCR-associated signals. J of Biol Chem. Sep 28;287(40):33215-26, 2012. PMCID: PMC3460427
70. Mali RS and Kapur R. Targeting Rho Associated Kinases in Leukemia and Myeloproliferative Neoplasms. Oncotarget. Sep;3(9):909-10, 2012. PMCID: in process.
71. Mali RS, Chan R and Kapur R. Targeting SHP2 phosphatase in Myeloproliferative Neoplasms. Oncotarget. Oct 8, 2012. [Epub ahead of print].
72. Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Fukuda S, Goenka S, Feng GS, Yu M, Sandusky
GE, Boswell HS, Zhang ZY, Kapur R, and Chan RJ. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Hematopoietic Progenitor Hyperproliferation and Malignant Disease In Vivo. Leukemia. Feb; 27 (2):398-408. doi:10.1038/leu.2012.308, 2012.
73. Stansfield BK, Bessler Wk, Mali R, Mund JA, Downing B, Li F, Sarchet KN, Distasi MR, Conway SJ, Kapur R, and Ingram DA. Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway. Hum Mol Genet. Mar 1; 22 (5):977-88. doi: 10.1093/hmg/dds502, 2013. PMCID: PMC3561913
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74. Mali R, and Kapur R. Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development. Cell Cycle. Jan 1; 12 (1):7-8. doi:10.4161/cc.23070, 2013. PMCID: PMC3570519
75. Shi J, Wu X, Surma M, Vemula S Zhang L, Yang Y, Kapur R, and Wei L. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell Death Dis. Feb7; 4:e483. doi:10.1038/cddis, 2013.
76. Martin H, Mali RS. Chatterjee A, Ramdas B, Ghosh J, Sims E, Munugalavadla V, Vlaar CP, Dharmawardhane S, and Kapur R. Role of p21-activated kinase and specific guanine exchange factors of Rac GTPase in oncogenic KIT induced systemic mastocytosis and acute myeloid leukemia. J Clin Invest. In Press.
77. Stansfield BK, Bessler Wk, Mali RS, Mund JA, Downing B, Kapur R, and Ingram DA. Ras-Mek-Erk signaling directly regulates Nf1 heterozygous neo-intima formation. American J of Pathology. Under revision
78. Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Vemula S, Bunting K, Shah N, Chan RJ and Kapur R. Unraveling a novel mechanism of Stat5 regulation by FAK, Rac1, and Pak1 in acute myeloid leukemia and myeloproliferative neoplasms. Cell Reports. In review.
PRESENTED ABSTRACTS (* ORAL PRESENTATION): 1. Acevedo A, Kapur R and Harris DT. Analysis of an evolutionary-conserved function-associated
molecule (FAM) on murine natural killer (NK) cells. Fifth International Dev. Comp. Immunol. Congress, Portland, OR, 1991.
2. * Kapur R, Acevedo A, Frye C, Christopher M, Kiefer J and Harris DT. Analysis of a novel
function-associated molecule (FAM) on murine natural killer cells. Arizona Branch A.S.M., April, 1991.
3. Harris DT, Kapur R, Acevedo A, Friedmann L and Evans DL. Analysis of a novel function-
associated molecule (FAM) on murine natural killer (NK) cells. FASEB, Atlanta, GA, 1991. 4. Harris DT, Kapur R, Frye C, Swiergiel J, Friedmann L and Evans DL. Analysis of a putative
antigen receptor on murine NK cells. 5th Midwinter Immunology Conference, Asilomar, CA, 1991.
5. * Kapur R, Swiergiel J, Frye C, Friedmann L, Evans D and Harris DT. Analysis of a novel
function-associated molecule on murine natural killer cells. FASEB, Anaheim, CA, 1992.
6. * Kapur R, Friedmann L, Evans D and Harris D. Analysis of a novel function-associated
molecule (FAM) on murine natural killer cells. AAI/CIS Meeting, Denver, CO, May, 1993.
7. * Kapur R, Evans D and Harris D. Molecular characterization of an intermediate filament
vimentin related function-associated molecule (fam) on murine natural killer cells. Annual Meeting Arizona Branch ASM, Pheonix, AZ, 1994.
Reuben Kapur, Ph.D. - CV 07152013 22
8. * Kapur R., Evans D and Harris D. Analysis of a vimentin-like function associated molecule
(FAM) on murine natural killer cells. Experimental Biology 94, Anaheim, CA, April, 1994. 9. Kapur R, Uffman J, Cooper R, Majumdar M and Williams DA. Defective thymocyte
development in mice overexpressing the human membrane-associated form of stem cell factor. Presented at the American Society of Hematology meeting, Seattle, Washington, December, 1995.
10. * Kapur R, Xiao X, Cooper R, Resnick J, Donovan PJ and Williams DA. Splicing defect of the
kit ligand cytoplasmic tail in steel17H mice results in diminished cell-associated protein with altered biological activity. Presented at the International Society of Experimental Hematology, Dusseldorf, Germany, August, 1995.
11. * Kapur R, Majumdar MK, Xiao X, Schindler K, McAndrews-Hill M, and Williams DA.
Transgenic expression of stem cell factor in Steel dickie mice: delineation of a unique role of membrane-associated protein in erythropoiesis. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 1996.
12. Maze R, Kapur R, and Williams DA. Genetically modified hematopoietic stem cells expressing
O6-methylguanine DNA methyltransferase via a retrovirus vector protect the lymphoid and stem cell compartments in long-term engrafted animals treated with nitrosurea. Biomedicine, Washington, DC, May, 1996.
13. * Kapur R, Majumdar MK, Xiao X, Schindler K, McAndrews-Hill M, and Williams DA. Signaling
via the interaction of membrane-restricted stem cell factor and KIT receptor tyrosine kinase: genetic evidence for a unique role in erythropoiesis. Presented at the International Society of Experimental Hematology, Cannes, France, August, 1997.
14. Oh SY, Kapur R, Bailey JR, Trammell JK and Williams DA. A ligand-stimulated internalization
deficient c-Kit mutant induces enhanced apoptosis in IC2 cells but differentiation in PC12 cells. Presented at the American Society of Hematology meeting, Miami Beach, Florida, December, 1998.
15. * Kapur R, Cooper R, Xiao X, Vik T and Williams DA. Presentation of stem cell factor affects
the kinetics of MAP-Kinase and PI-3Kinase/Akt phosphorylation in hematopoietic cells. Presented at the American Society of Hematology meeting, Miami Beach, Florida, December, 1998.
16. * Kapur R, Cooper R, Xiao X, Donovan P, and Williams DA. Impaired c-Kit signaling in
response to abnormal presentation of stem cell factor results in lympho-hemopoietic defects in Steel17H mice. Presented at the American Society of Hematology meeting, Miami Beach, Florida, December, 1998.
17. * Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock J, Borneo JB,
Bradford GB, Atkinson SJ, Dinauer MC, and Williams DA. Deficiency of the hematopoietic cell-specific Rho-family GTPase, Rac2, is characterized by multiple abnormalities in neutrophil function and impaired host defense. Presented at the American Society of Hematology meeting, Miami Beach, Florida, December, 1998.
Reuben Kapur, Ph.D. - CV 07152013 23
18. * Kapur R, Cooper R, Kato I and Williams DA. Suppression of p38 mitogen activated protein
kinase activation is required for inhibiting integrin VLA-4 adhesion-induced apoptosis in hematopoietic cells. Presented at the American Society of Hematology meeting, New Orleans, Louisiana, December, 1999.
19. Kapur R, Cooper R, Kato I and Williams DA. Functional and biochemical evidence for
adhesion-induced “cross-talk” between a receptor tyrosine kinase and integrins: differential collaboration of c-Kit with VLA-4 and VLA-5 in hematopoietic cells. Presented at the American Society of Hematology meeting, New Orleans, Louisiana, December, 1999.
20. * Yang FC, Kapur R, Borneo JB, Roberts A and Williams DA. Enhanced growth factor induced
apoptosis in mast cells derived from Rac2-deficient mice: a novel role of Rac2 in Akt-mediated survival of mast cells. Presented at the American Society of Hematology meeting, New Orleans, Louisiana, December, 1999
21. * Yang FC, Kapur R, King AJ, Tao W, Borneo JB and Williams DA. Rac2 regulates the
activation of Akt and the balance between pro- and anti-apoptotic proteins Bad and Bcl-xL. Presented at the International Society of Experimental Hematology meeting, Tampa, Florida, July, 2000.
22. Yi Q, Marques S, Dy LC, Smietana E, Kapur R, Spandau DF, and Travers JB. The epidermal
platelet-activating factor receptor stimulates multiple mitogen-activated protein kinase pathways. Journal of Investigative Dermatology, 114:870, 2000.
23. Kapur R, Cooper R, Ito I and Williams DA. Distinct signaling pathways control opposing affects
of VLA-4 and VLA-5 mediated growth, survival and differentiation in hematopoietic cells. Keystone Symposium, Breckenridge, Colorado, March, 2000.
24. Hiatt KK, Ingram DA, Hong L, Kapur R, and Clapp DW. Loss of Nf1 reduces Fas ligand-
mediated apoptosis in murine bone marrow derived mast cells in response to stem cell factor. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2001.
25. Tan BL, Hong L, and Kapur R. Functional and biochemical consequences of abrogating the
activation of diverse signaling pathways in c-Kit: restoration of Src signaling pathway in c-Kit alone is sufficient to partially restore cooperation with Epo-R. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2001.
26. Ingram DA, Zhang L, McCarthy J, Wenning MJ, Fisher L, Clapp DW, and Kapur R.
Neurofibromin tumor suppressor gene functions as a GAP for Ras in T cells: Functional and biochemical consequences of Nf1 heterozygosity and homozygosity. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2001.
27. * Tan BL, Yazicioglu MN, Ingram DA and Kapur R. A novel role for c-Kit in modulating a4b1-
integrin directed migration of hematopoietic cells: Biochemical and genetic evidence for convergence of c-Kit and a4b1-integrin mediated signals on PI-3Kinase/Rac pathway. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2001.
28. * Ingram DA, Chen S, Fisher L, Wenning MJ, Huddleston H, Atkinson S, Williams DA, Kapur R,
and Clapp DW. Haploinsufficiency of the Nf1 tumor suppressor gene enhances the migration of
Reuben Kapur, Ph.D. - CV 07152013 24
mast cells via increased adhesion to VLA-4 and hyperactivation of the Ras-PI-3K-Rac2 pathway. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
29. Li K, Miller C, Hedge S, Barber D, Kapur R, and Wojchowski DM. Roles for Epo receptor Y343
in Kit synergy. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
30. Chandra S, Kapur R, Barker J and Williams DA. Rare mechanism of mutation leads to a unique
Steel gene rearrangement and lethal allele. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
31. Chandra S, Harris CE, Lanner C, Summey V, Kapur R, and Williams DA. Novel mutant of
murine associated with reduced proliferation of fetal liver progenitor cells. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
32. Hong L, Munugalavadla V, Tan B, and Kapur R. Functional and biochemical consequences of
restoring diverse early signaling pathways in a naked c-Kit receptor: Src pathway is sufficient to completely restore survival and migration but not proliferation. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
33. * Huddleston H, Kapur R, Tan B, Yang FC, Wenning MJ, Yoder MC, and Ingram DA. Genetic
reduction of class IA PI-3Kinase activity disrupts normal murine fetal erythropoiesis in vivo. Presented at the American Society of Hematology meeting, Orlando, Florida, December, 2002.
34. * Ingram DA, Chen S, Fisher L, Wenning MJ, Huddleston H, Atkinson S, Williams DA, Kapur R,
and Clapp DW. Haploinsufficiency of the Nf1 tumor suppressor gene enhances the migration of mast cells via increased adhesion to VLA-4 and hyperactivation of the Ras-PI-3K-Rac2 pathway. International Society of Experimental Hematology, Quebec, June, 2002.
35. Hong L, Munugalavadla V, and Kapur R. Functional and biochemical consequences of
restoring diverse early signaling pathways in a naked c-Kit receptor: Src pathway is sufficient to completely restore survival and migration but not proliferation. Presented at the International Society of Experimental Hematology meeting, July, 2003.
36. Yang FC, Ingram DA, Chen S, Ratner N, Monk K, White H, Mead L, Atkinson S, Kapur R,
Williams DA, Clapp DW. Loss of the Nf1 tumor suppressor gene in Schwann cells provides a potent stimulus for mast cell migration via secretion of soluble Kit ligand. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
37. * Ingram DA, White H, Hong P, Yang FC, Kapur R, Haneline LS. Genetic Disruption of Class IA
PI-3 kinase activity disrupts fetal hematopoiesis and competitive repopulating ability In Vivo. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
38. Borneo J, Munugalavadla V, Koon D, McCarthy J, and Kapur R. Lyn Src Family Kinase is both
a Positive and a Negative Regulator of Hematopoiesis: A Novel Dual Role for Lyn in Regulating Growth and Survival of Primitive Stem/Progenitor Cells and Lineage Committed Mast Cells. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
Reuben Kapur, Ph.D. - CV 07152013 25
39. Munugalavadla V, Ingram DA, and Kapur R. p85 Subunit of Class IA PI-3Kinase Plays an Essential Role in regulating Growth and Actin based functions in Macrophages. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
40. Li B, Jia N, Kapur R, and Chun K. Enforced expression of CUL-4A interferes with erythrocyte
differentiation and exit from the cell cycle and promotes proliferation in erythroblasts. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
41. * Munugalavadla V, Tan B, Hong L, Reddy A, Weiss M and Kapur R. GATA-1 represses c-Kit
signaling to inhibit cell proliferation during erythroid maturation. Presented at the American Society of Hematology meeting, San Diego, California, December, 2003.
42. Borneo J, Orschell CM, Munugalavadla V, and Kapur R. Genetic Evidence for a Role of Src
Kinases in Mobilization, Homing and Engraftment of Hematopoietic Stem Cells: Deficiency of Src Kinases Results in Enhanced G-CSF Induced Mobilization. Blood, Nov 2004; 104: 1292. Presented at the American Society of Hematology meeting, San Diego, California, December, 2004.
43. Munugalavadla V, Hong L, White H, Ingram DA, and Kapur R. Differential Role for pP85 and
p85ß Regulatory Subunits of Class IA PI-3Kinase in Mast Cell Growth and Maturation. Blood, Nov 2004; 104: 2162. Presented at the American Society of Hematology meeting, San Diego, California, December, 2004.
44. Li K, Karur V, Vincent B, Curato J, Kapur R, Besmer P, and Wojchowski DM. Kit PY567-
Directed Signals Are Important for Efficient Erythroid Progenitor Cell Proliferation and Survival, and Are Attenuated by Kit PY569. Blood, Nov 2004; 104: 2168. Presented at the American Society of Hematology meeting, San Diego, California, December, 2004.
45. Munugalavadla V, Borneo J, Chen J, and Kapur R. Opposing Roles for Class IA PI-3Kinase
and Src Family Kinase in Regulating Myeloid Cell Growth and Lineage Commitment. Blood, Nov 2004; 104: 3543. Presented at the American Society of Hematology meeting, San Diego, California, December, 2004.
46. Munugalavadla V, Sims E, Ingram DA, Robling A, and Kapur R. p85 Regulatory Subunit of
Class IA PI-3Kinase Regulates Osteoclast Function(s) and Bone Mass. Blood, Nov 2005; 106: 2223. Presented at the American Society of Hematology meeting, Atlanta, Georgia, December, 2005.
47. Munugalavadla V, Sims E, Borneo J, and Kapur R. Gleevec Resistant Activating Mutation of c-
Kit (D816V) Demonstrates Ligand Independent Growth and Promiscuous Cooperation with Multiple Cytokine Receptors Via the p85 Subunit of Class IA PI-3Kinase. Blood, Nov 2005; 106: 3530. Presented at the American Society of Hematology meeting, Atlanta, Georgia, December, 2005.
48. * Chen J, Vemula S, and Kapur R. Structure Function Analysis of Hematopoietic Specific Src
Family Kinases Lyn, Hck and Fgr Reveal a Critical Role for Lyn’s Unique Domain in Regulating Growth of Myeloid Cells That Is Distinct from the Role of Hck and Fgr’s Unique Domain. Blood, Nov 2005; 106: 68. Presented at the American Society of Hematology meeting, Atlanta, GA, December, 2005.
Reuben Kapur, Ph.D. - CV 07152013 26
49. Kapur R, Wayne A, Metcalfe D, Carter M, Shahlaee A, and Takemoto C. Kit Signaling regulates Mitf Expression in Mastocytosis. Presented at the American Society for Hematology, Orlando, Fl, December 2006.
50. Veerendra Munugalavadla, Clifford Takemoto, Emily Sims, Alexander Robling, Feng-Chun Yang
and Reuben Kapur. p85α subunit of class IA PI-3Kinase regulates the expression of multiple genes involved in osteoclast differentiation and migration. Presented at the Keystone Symposia, Santa Fe, NM, February, 2007.
51. Munugalavadla V, Sims EC, Borneo J, Chan RJ, and Kapur R. Genetic and Pharmacologic
Evidence Implicating the p85α, but not p85β, Regulatory Subunit of PI-3Kinase and Rac2 GTPase in Regulating Oncogenic KIT Induced Transformation in Acute Myeloid Leukemia and Systemic Mastocytosis. Presented at the Keystone Symposia, Santa Fe, NM, February, 2007.
52. * Krishnan S, Munugalavadla V, and Kapur R. Differential role of p85α and p85β regulatory
subunits of class IA PI-3Kinase in mast cell growth and differentiation. Presented at the Keystone Symposia, Santa Fe, NM, February,2007.
53. * Munugalavadla V, Sims EC, and Kapur R. Genetic and Pharmacologic Evidence Implicating
the p84α, but not p85β, Regulatory Subunit of PI-3Kinase and Rac2 GTPase in Regulating Oncogenic KIT Induced Transformation in Acute Myeloid Leukemia and Systemic Mastocytosis. Presented at the 5th Midwest Blood Club Meeting in Cincinnati, OH, April, 2007.
54. Munugalavadla V, Sims EC, Lenz SD, and Kapur R. Requirement for p85α regulatory subunit
of class IA PI3Kinase and Rac2 GTPase in myeloproliferative disease driven by activation loop mutant of KIT. Presented at the Genetics Retreat, Indiana University, Indianapolis, IN, September, 2007.
55. Ma P and Kapur R. Repression of ROCKII by GATA-1 inhibits cell proliferation during erythroid
maturation. Presented at the Genetics Retreat, Indiana University, Indianapolis, IN, September, 2007.
56. Vemula S, Abratigue BP, Gandra P, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan M, Beggs
H, and Kapur R. Focal adhesion kinase regulates critical functions in hematopoiesis. Presented at the Genetics Retreat, Indiana University, Indianapolis, IN, September, 2007.
57. Vemula S, Gandra P, Shi J, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan M, Wei L, and
Kapur R. ROCKI regulates critical functions in macrophages and neutrophils. Presented at the Genetics Retreat, Indiana University, Indianapolis, IN, September, 2007.
58. Munugalavadla V, Sims EC, Lenz SD, and Kapur R. Requirement for p85α regulatory subunit
of class IA PI3Kinase and Rac2 GTPase in myeloproliferative disease driven by activation loop mutant of KIT. Presented at the Biochemistry and Molecular Biology Research Day, Indiana University, Indianapolis, IN, September, 2007.
59. Ma P, and Kapur R. Repression of ROCKII by GATA-1 inhibits cell proliferation during erythroid
maturation. Presented at the Biochemistry and Molecular Biology Research Day, Indiana University, Indianapolis, IN, September, 2007.
60. Vemula S, Abratigue BP, Gandra P, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan M, Beggs
H, and Kapur R. Focal adhesion kinase regulates critical functions in hematopoiesis.
Reuben Kapur, Ph.D. - CV 07152013 27
Presented at the Biochemistry and Molecular Biology Research Day, Indiana University, Indianapolis, IN, September, 2007.
61. Vemula S, Gandra P, Shi J, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan M, Wei L, and
Kapur R. ROCKI regulates critical functions in macrophages and neutrophils. Presented at the Presented at the Biochemistry and Molecular Biology Research Day, Indiana University, Indianapolis, IN, September, 2007.
62. * Munugalavadla V, Sims EC, and Kapur R. Genetic and Pharmacologic Evidence Implicating
the p85α, but not p85β, Regulatory Subunit of PI-3Kinase and Rac2 GTPase in Regulating Oncogenic KIT Induced Transformation in Acute Myeloid Leukemia and Systemic Mastocytosis. Presented at the International Society for Hematology, Hamburg, Germany, September, 2007.
63. * Munugalavadla V, Sims EC, and Kapur R. Genetic and pharmacologic evidence implicating
the p85α, but not p85β, regulatory subunit of PI-3Kinase and Rac2 GTPase in regulating oncogenic KIT induced transformation in acute myeloid leukemia and systemic mastocytosis. Presented at the Midwest Society for Pediatric Research, Indianapolis, IN, October, 2007.
64. Ma P and Kapur R. Repression of ROCKII by GATA-1 inhibits cell proliferation during erythroid
maturation. Presented at the American Society of Hematology, Atlanta, GA, December, 2007. 65. Vemula S, Abratigue BP, Gandra P, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan N, Beggs
H, and Kapur R. Focal adhesion kinase regulates critical functions in hematopoiesis. Presented at the American Society of Hematology, Atlanta, GA, December, 2007.
66. Vemula S, Gandra P, Shi J, O’Malley JT, Ahyi AN, Stritesky G, Yeh N, Kaplan M, Wei L, and
Kapur R. ROCKI regulates critical functions in macrophages and neutrophils. Presented at the American Society of Hematology, Atlanta, GA, December, 2007.
67. * Munugalavadla V, Sims EC, Lenz SD, and Kapur R. Requirement for p85α regulatory subunit
of class IA PI3Kinase and Rac2 GTPase in myeloproliferative disease driven by activation loop mutant of KIT. Presented at the American Society of Hematology, Atlanta, GA, December, 2007.
68. Munugalavadla V, Sims EC, Shi J, Wei L, and Kapur R. ROCKI regulates growth, maturation
and migration of mast cells. Presented at the American Society of Hematology, Atlanta, GA, December, 2007.
69. *Nabinger SC, Kapur R, and Chan RJ. The Role of Shp2 in Flt3-ID-Induced Leukemogenesis.
Presented at the International Neonatal Hematology and Immunology Meeting, Boston, MA, July, 2008.
70. Vemula S, Shi J, Wei L, Kapur R. ROCK1 negatively regulates macrophage and neutrophil
migration by regulating the activation of PTEN. Presented at the Microbiology & Immunology Research Session, Indiana University, Indianapolis, IN, September, 2008.
71. * Vemula S, Shi J, Wei L, Kapur R. ROCK1 negatively regulates macrophage and neutrophil
migration by regulating the activation of PTEN. Presented at the Medical & Molecular Genetics 2nd Annual Retreat, Indiana University, Indianapolis, IN, September, 2008.
Reuben Kapur, Ph.D. - CV 07152013 28
72. Vemula S, Shi J, Wei L, Kapur R. ROCK1 negatively regulates macrophage and neutrophil
migration by regulating the activation of PTEN. Presented at the 2008 Biochemistry & Molecular Biology Research Day, Indiana University, Indianapolis, IN, October, 2008.
73. Nabinger SC, Fukuda S, Kapur R, and Chan RJ. The role of Protein Tyrosine Phosphatase,
Shp2, in FLT3-ITD-Induced Leukemogenesis. Presented at the American Society for Hematology, San Francisco, CA, December, 2008.
74. * Vemula S, Shi J, Wei L, and Kapur R. ROCK1 negatively regulates macrophage and
neutrophil migration by regulating the activation of PTEN. Presented at the 2009 Midwest Blood Club, Cincinnati, OH, April, 2009.
75. * Li F, Estes M, Vemula S, Lasater EA, Bessler WK, Kapur R, Case, J, and Ingram DA. A
Mouse Model of Aneurysm in Neurofibromatosis Type I. Presented at the Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2009, Washington, D.C., April, 2009.
76. *Kapur R, Vemula S, Shi J, Hanneman PH, Wei L. ROCK1 negatively regulates macrophage
and neutrophil migration by regulating the activation of PTEN. Presented at the International Society for Hematology and Stem Cells Scientific Annual Meeting, Athens, Greece, September, 2009.
77. Martin H and Kapur R. Cooperation of AML1-ETO and Oncogenic KIT in Acute Myelogenous
Leukemia. Presented at Indiana University Medical Genetics Symposium, Indianapolis, IN, October, 2009.
78. Ma P, Martin H, Sims E, Ramdas B, Ghosh J, and Kapur R. Role of Intracellular Tyrosine
Residues of KIT on Oncogenic Transformation. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
79. Mali R, Ramdas B, Munugalavadla V, Sims E, and Kapur R. Rho Kinase Inhibitors as Potential
Therapeutic Agents for Oncogenic KIT, FLT3, and BCR-ABL Induced Leukemogenesis. Presented at the 51st American Society of Hematology, New Orleans, Louisiana, December, 2009.
80. *Mali R, Krishnan S, Ramdas B, Munugalavadla V, Sims E, Hanneman P, and Kapur R.
Differential Role of Class 1A PI 3-Kinase regulatory subunits in Mast Cell Growth, Maturation and Survival. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
81. Vemula S, Ramdas B, Hanneman PH, Beggs H, and Kapur R. Role of Focal Adhesion Kinase
in Myelotoxicity, Inflammatory Strees Response and Myeloid Cell Functions. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
82. *Vemula S, Shi J, Hanneman PH, Wei L, and Kapur R. ROCK1 functions as a Suppressor of
Inflammatory Cell Migration by Regulating PTEN Phosphorylation and Stability. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
Reuben Kapur, Ph.D. - CV 07152013 29
83. *Nabinger SC, He Y, Yin F, Zhang X, Senganjo LT, Fukuda S, Yu M, Feng GS, Zhang ZY, Kapur R, and Chan R. Targeting the Protein Tyrosine Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
84. Goodwin CB, Yang Z, Vemula S, Yin F, Kapur R, and Chan RJ. Genetic Disruption of he PI3K
Regulatory Subunit, p85 Partially Normalizes Gain-of-Function PTPN11-Induced Hypersensitivity to GM-CSF in Hematopoietic Progenitors. Presented at the American Society of Hematology, New Orleans, Louisiana, December, 2009.
85. Mali R, Ramdas B, Munugalavadla V, Sims E, and Kapur R. Rho Kinase Inhibitors as Potential
Therapeutic Agents for Oncogenic KIT, FLT3, and BCR-ABL Induced Leukemogenesis. Presented at the Indiana University School of Medicine 2010 Biochemistry and Molecular Biology Research Day, Indianapolis, IN, February, 2010.
86. Ma P, Martin H, Sims E, Ramdas B, Ghosh J, and Kapur R. Role of Intracellular Tyrosine
Residues of KIT on Oncogenic Transformation. Presented at the Indiana University School of Medicine 2010 Biochemistry and Molecular Biology Research Day, Indianapolis, IN, February, 2010.
87. Vemula S, Ramdas B, Hanneman PH, Beggs H, and Kapur R. Role of Focal Adhesion Kinase
in Myelotoxicity, Inflammatory Stress Response and Myeloid Cell Functions. Presented at the Indiana University School of Medicine 2010 Biochemistry and Molecular Biology Research Day, Indianapolis, IN, February, 2010.
88. *Martin H, Ma P, Ramdas B, and Kapur R. Cooperation of AML1-ETO and Oncogenic KIT
Acute Myelogenous Leukemia. Presented at the Indiana University Research Day, Indianapolis, IN, March, 2010.
89. Vemula S, Ramdas B, Hanneman PH, Beggs H, and Kapur R. Role of Focal Adhesion Kinase
in Myelotoxicity, Inflammatory Stress Response and Myeloid Cell Functions. Presented at the Indiana University Cancer Research Day, Indianapolis, IN, May, 2010.
90. Mali R, Krishnan S, Ramdas B, Munugalavadla V, Sims E, Hanneman P, and Kapur R.
Differential Role of Class 1A PI 3-Kinased Regulatory Subunits in Mast Cell Growth, Maturation and Survival. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2010.
91. Ma P, Martin H, Sims E, Ramdas B, Ghosh J, and Kapur R. Role of Intracellular Tyrosine
Residues of KIT on Oncogenic Transformation. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2010.
92. Mali RS, Ramdas B, Ma P, Munugalavadla V, Sims E, Boswell HS, and Kapur R. Evidence for ROCK as potential therapeutic target for treatment of hematologic malignancies involving oncogenic KIT, FLT3, and BRC-ABL. Presented at the Indiana University Cancer Research Day, Indianapolis, IN, 2010.
93. Martin H, Ma P, Ramdas B, and Kapur R. Cooperation of AML1-ETO and Oncogenic KIT Acute
Myelogenous Leukemia. Presented at the Indiana University Cancer Research Day, Indianapolis, IN, May, 2010.
Reuben Kapur, Ph.D. - CV 07152013 30
94. Vemula S, Ramdas B, Hanneman PH, Martin J, Beggs H, and Kapur R. Essential Role for Focal Adhesion Kinase in Regulating Stress Hematopoiesis. Presented at the Midwest Blood Club, Indianapolis, IN, May, 2010.
95. *Mali R, Krishnan S, Ramdas B, Munugalavadla V, Sims E, Hanneman P, and Kapur R.
Differential Role of Class 1A PI 3-Kinased Regulatory Subunits in Mast Cell Growth, Maturation and Survival. Presented at the 8th Midwest Blood Club, Indianapolis, IN, May, 2010.
96. Mali RS, Ramdas B, Ma P, Mungalavadla V, Sims E, Boswell HS, and Kapur R. Evidence for ROCK as potential therapeutic target for treatment of hematologic malignancies involving oncogenic KIE, FLTs and BCR-ABL. Presented at the 8th Midwest Blood Club, Indianapolis, IN, May, 2010.
97. *Ma P, Martin H, Sims E, Ramdas B, Ghosh J, and Kapur R. Role of Intracellular Tyrosine
Residues of KIT on Oncogenic Transformation. Presented at the Midwest Blood Club, Indianapolis, IN, May, 2010.
98. Martin H, Ma P, Ramdas B, and Kapur R. Cooperation of AML1-ETO and Oncogenic KIT Acute
Myelogenous Leukemia. Presented at the Midwest Blood Club, Indianapolis, IN, May, 2010. 99. Wen QJ, Huang A, Small S, An F, Bliss-Moreau M, VerPlank L, Lewis T, Schenone M, Tolliday
N, Moore C, Bittker J, Vokes M, Carpenter A, Vemula S, Shi J, Wei L, Kapur R, Mercher T, Levine R, Izraeli S, Stern AM, Gould R, Bradner J, and Crispino JD. High-throughput screen targeting polyploidization in megakaryocytes identified small molecules efficacious in acute megakaryocytic leukemia. Presented at the Midwest Blood Club, Indianapolis, IN, May, 2010.
100. Chatterjee A, Vemula S, Ramdas B, Martin H, Nabinger SC, Chan RJ, Kapur R. Novel
signaling pathway in Flt3ITD mediated leukemogenesis. Presented at the Midwest Blood Club, Cincinnati, OH, April, 2011.
101. Kapur R, Ma P, Zeng L, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger SC, Li S,
Munugalavadla V, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, and Mali RS. KIT induced myeloproliferative disease is dependent on PI3Kinase and SHP2 phosphatase: Identification of SHP2 as a novel druggable target for treating MPD and AML. Presented at the 9th Midwest Blood Club, Cincinnati, OH, April, 2011.
102. Mali RS, Ramdas B, Ma P, Munugalavadla V, Sims E, Shi J, Wei L, Lewis TA, Stern AM, Wen
Q, Crispino JD, Boswell HS, and Kapur R. Phosphorylation of myosin light chain by Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT. Presented at the 9th Midwest Blood Club, Cincinnati, OH, April, 2011.
103. Martin H, Chatterjee A, Ma P, Ramdas B and Kapur R. RAC GTPases and PAK as potential
Therapeutic Targets of Oncogenic KIT in Acute Myelogenous Leukemia. Presented at the Midwest Blood Club, Cincinnati, OH, April, 2011
104. Ghosh J, Ramdas B, Mali RS, Chatterjee A, Ma P, and Kapur R. Role of S6K1 in regulation of normal and stress hematopoiesis. Presented at the Indiana University Cancer Research Day, Indianapolis, IN, 2011.
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105. Chatterjee A, Ramdas B, Vemula S, Mali RS, Ghosh J, Martin H, Nabinger SC, Goodwin CB, Chan RJ and Kapur R. Fak is a nove therapeutic target in Flt3-ITD medicated leukemogenesis. Presented at the Indiana University Cancer Research Day, Indianapolis, IN, 2011.
106. Martin H, Chatterjee A, Ma P, Ramdas B, Sims E, and Kapur R. p21 Activated kinase (PAK) as
a Potential Therapeutic Target for Oncogenic KIT in Acute Myelogenous Leukemia. Presented at the International Society for Hematology Meeting, Vancouver, Canada, August, 2011
107. Ma P, Mali RS, Zeng LF, martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger S., Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, and Kapur R. Role of SHP2 phosphatase in KIT induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Presented at the 53rd Annual Meeting of the American Society for Hematology, Atlanta, GA. December, 2011.
108. Vemula S, Shi J, Mali RS, Ma P, Hanneman P, Wei L and Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Presented at the 53rd Annual Meeting of the American Society for Hematology, Atlanta, GA. December, 2011.
109. Ghosh J, Ramdas B, Ma P, Mali RS and Kapur R. Role of p70s6 kinase in regulation of
hematopoiesis. Presented at the IBMG Campus Research Day, Indianapolis, IN, January, 2012.
110. *Chatterjee A, Vemula S, Ramdas B, Mali RS, Ghosh J, Martin H, Nabinger SC, Goodwin C,
Chan RJ, and Kapur R. “FAK is a novel therapeutic target in Flt3-ITD mediated leukemogenesis.” Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
111. Martin H, Ma P, Chatterjee A, Ramdas B, Sims E, and Kapur R. Genetic Disruption and
Pharmacologic Inhibition of the Vav-Rac-PAK Signaling Pathway Suppresses Oncogenic KIT Mediated Leukemogenesis. Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
112. Hu P, Carlesso N, Xu M, Liu Y, Nebreda AR, Takemoto C, and Kapur R. Genetic evidence for
a critical role of P38α in regulating mast cell differentiation and chemotaxis through distinct mechanisms. Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
113. Vemula S, Shi J, Mali RS, Ma P, Hanneman P, Wei L and Kapur R. ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53. Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
114. Martin H, Ma P, Chatterjee A, Ramdas B, Sims E, and Kapur R. Genetic Disruption and Pharmacologic Inhibition of the Vav-Rac-PAK Signaling Pathway Suppresses Oncogenic KIT Mediated Leukemogenesis. Presented at the St. Jude national Graduate Student Symposium, Memphis, TN, March, 2012.
115. Chatterjee A, Ramdas B, Vemula S, Mali RS, Ghosh J, Martin H, Nabinger SC, Goodwin C,
Chan R, and Kapur R. FAK is a novel therapeutic target in FLT3-ITD mediated leukemogenesis. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2012
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116. Goodwin CB, Gearinger RL, Mali RS, Chan G, Neel BG, Kapur R, and Chan RJ. The PI3K catalytic subunit p100δ us a crucial mediator of leukemia-associated mutant PTPN11-induced GM-CSF hypersensitivity. Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
117. Chatterjee A, Ramdas B, Vemula S, Mali RS, Ghosh J, Martin H, Nabinger SC, Goodwin C, Chan R, and Kapur R. FAK is a novel therapeutic target in FLT3-ITD mediated leukemogenesis. Presented at the 10th Annual Midwest Blood Club Symposium, Indianapolis, IN, March, 2012.
118. Ghosh J, Ramdas B, Mali RS, Chatterjee A, Ma P, and Kapur R. Role of S6K1 in regulation of normal and stress Hematopoiesis. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2012.
119. Canela V, Ghosh J, Chatterjee A, and Kapur R. Inhibition of FAK as a potential therapeutic option in treating FLT3 and c-KIT induced leukemogenesis. Presented at the Indian University School of Medicine Summer Student Presentations, Indianapolis, IN, August, 2012.
120. Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Richine B, Bowling J, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky G, Boswell HS, Zhang ZY, Kapur R, and Chan RJ. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT-3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT-3-IDT-Expressing Leukemic Cells. Presented at the American Society for Hematology, Atlanta, GA. December, 2012.
121. *Chatterjee A, Ghosh J, Ramdas B, Vemula S, Martin H, Mali R, Nabinger SC, Goodwin CB, Boswell HS, Chan RJ, and Kapur R. Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in flt3ITD Induced leukemogenesis. Presented at the 54th American Society for Hematology, Atlanta, GA. December, 2012.
122. *Martin H, Ma P, Chatterjee A, Ramdas B, Sims E, Cornelis PV, Dharmawardhane S, and Kapur R. Role of p21 Activated Kinase and Specific Guanine Exchange Factors of Rac GTPases in Oncogenic KIT Induced Systemic Mastocytosis and Acute Myeloid Leukemia. Presented at the American Society for Hematology, Atlanta, GA. December, 2012.
123. * Goodwin CB, Gearinger RL, Mali RS, Chan G, Neel BG, Kapur R, and Chan RJ. The PI3K catalytic subunit p110δ us a crucial mediator of leukemia-associated mutant PTPN11-induced GM-CSF hypersensitivity. Presented at the 6th International Symposium on MDS and Bone Marrow Failure Syndromes in Childhood, Prauge, Czech Republic, 2012.
124. Ghosh J, Ramdas B, Quilliam L, and Kapur R. Rap1 is a potential therapeutic target for non-myeloablative conditioning. Presented at the Indiana University Research Day, Indianapolis, IN. April, 2013.
125. Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Vemula S, Chan R, and Kapur R. Unraveling a novel mechanism of Stat5 regulation in oncogenic Flt3 induced Acute Myeloid Leukemia. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2013.
126. Ghosh J, Ramdas B, Chatterjee A, Zollman A, Carlesso N, Quilliam L, and Kapur R. Rap1
GTPase Regulates the Retention and Self-renewal of Hematopoietic Stem Cells in the Bone
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Marrow Niche. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2013.
127. Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Vlaar CP, Dharmawardhane S, and Kapur R. P21-Activated Kinase and Specific Guanine Exchange Factor of Rac GTPases in oncogenic Kit induces Systemic Mastocytosis and Acute Myeloid Leukemia. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2013.
128. Hu P, Nebreda AR, and Kapur R. P38α Intrinsically Regulates Stress Erythropoiesis Through Controlling Survival of Erythroid Precursors. Presented at the Indiana University Cancer Research Day, Indianapolis, IN. May, 2013.
