CURRICULUM VITAE Mustafa F. Lokhandwala, Ph.D ... VITAE Mustafa F. Lokhandwala, Ph.D. EDUCATION...

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CURRICULUM VITAE Mustafa F. Lokhandwala, Ph.D. EDUCATION Degree Year Institution Field B.Pharm 1966 L.M.College of Pharmacy Pharmacy Ahmedabad, India M.S. l968 Columbia University Pharmacology New York, New York Ph.D. 1975 University of Houston Pharmacology Houston, Texas PROFESSIONAL APPOINTMENTS Title Institution Dates Dean College of Pharmacy 2008-2009 University of Houston Director Heart and Kidney Institute 2006-present University of Houston Executive Vice Dean College of Pharmacy 2003-present For Research University of Houston Dean College of Pharmacy 1991-2002 University of Houston Professor Department of Pharmacology 1989-present University of Houston Chairman Department of Pharmacology 1980-1991 University of Houston Associate Professor Department of Pharmacology 1981-1989 University of Houston Assistant Professor Department of Pharmacology 1975-1981 University of Houston Research Assistant Department of Pharmacology 1970-1971 Columbia University/Ciba-Geigy New York and Tuckhoe, N.Y.

Transcript of CURRICULUM VITAE Mustafa F. Lokhandwala, Ph.D ... VITAE Mustafa F. Lokhandwala, Ph.D. EDUCATION...

CURRICULUM VITAE

Mustafa F. Lokhandwala, Ph.D.

EDUCATION Degree Year Institution Field B.Pharm 1966 L.M.College of Pharmacy Pharmacy Ahmedabad, India M.S. l968 Columbia University Pharmacology New York, New York Ph.D. 1975 University of Houston Pharmacology Houston, Texas PROFESSIONAL APPOINTMENTS Title Institution Dates Dean College of Pharmacy 2008-2009 University of Houston Director Heart and Kidney Institute 2006-present University of Houston Executive Vice Dean College of Pharmacy 2003-present For Research University of Houston Dean College of Pharmacy 1991-2002 University of Houston Professor Department of Pharmacology 1989-present University of Houston Chairman Department of Pharmacology 1980-1991 University of Houston Associate Professor Department of Pharmacology 1981-1989 University of Houston Assistant Professor Department of Pharmacology 1975-1981 University of Houston Research Assistant Department of Pharmacology 1970-1971 Columbia University/Ciba-Geigy New York and Tuckhoe, N.Y.

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OTHER APPOINTMENTS Adjunct Professor Hypertension & Clinical Pharmacology 1989-present Baylor College of Medicine Houston, Texas Adjunct Associate Hypertension & Clinical Pharmacology 1986-1989 Professor Baylor College of Medicine Houston, Texas Visiting Professor University of Rome September, 1989 Rome, Italy Visiting Professor The Third Military Medical University March, 2007 Chongqing, P.R.China RESEARCH INTERESTS, TRAINING AND TECHNIQUES Cardiovascular and Renal Pharmacology Hypertension and Antihypertensive Drug Mechanisms Central and peripheral control of the cardiovascular and renal function Role of oxidative stress in hypertension, diabetes and aging

- receptor-G protein coupling - drug responsiveness - antioxidant supplementation - redox imbalance and role of transcription factors - activators of antioxidant responsive elements

Dopamine, Dopamine Receptor Agonists and Cardiovascular Function Dopamine receptor function in obesity, diabetes, hypertension and aging Dopamine receptor mediated cellular signalling mechanisms in the proximal tubule Role of kidney dopamine in sodium balance and control of blood pressure Oxidative stress and D1 receptor signal transduction in the kidney Research Techniques

Measurements of inflammatory, reactive oxygen species and several biomarkers in hypertension, aging and diabetes

In vivo measurements of cardiac function including output, contractility

Measurements of venous return and vascylar rsistance in various beds

Sympathetic nerve stimulation induced changes in cardiac and renal function

Measurements of renal function including renal plasma flow, glomerular filtration rate, sodium excretion, pressure natriuresis relationships

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Cardiovascular and renal responses to drugs and other maneuvers in models of diabetes, hypertension and aging. .

Research Accomplishments Identification of presynaptic dopamine receptors on sympathetic nerve terminals under

in vivo conditions and the demonstration that activation of these receptors was responsible, at least in part for the vasodilator action of dopamine.

Demonstration of the uncoupling of D1 receptor in proximal tubule from the G-protein

in hypertension and in aging

Hyperglycemia and hyperinsulinemia contribute to receptor-G protein uncoupling in type I and type II diabetes, respectively. Improvement of insulin sensitivity in diabetic rats with drug therapy restores D1 receptor-G protein coupling and renal responsiveness to dopamine. The mechanism by which oxidative stress and inflammation contribute to various diseases: Studies on the role of NFkB, Nrf2 and Phase II antioxidant enzymes. AWARDS & HONORS University of Houston chapter of Sigma Xi, The Scientific Research Society’s Research Excellence Award for 1993. Individual Educational Excellence Award, Texas Pharmacy Foundation, 2000 Robert A. Boblitt Rho Chi Lectutre, 2004 TEACHING EXPERIENCE Pharmacology Principles of Drug Action Hypertension/Antihypertensive Agents Angina/Antianginal Agents Graduate Courses Adrenergic/Cholinergic Pharmacology Cardiovascular pharmacology Cardiovascular research techniques Advances in renal pharmacology GRADUATE STUDENTS

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A. A. Martinez, Ph.D. (l980) Dissertation title: Involvement of sympathetic nervous system in the cardiovascular

actions of 5-hydroxytryptamine G. J. Hom, M.S. (l980) Thesis title: Presynaptic inhibition of sympathetic nervous system by adenosine: physiological & pharmacological implications S. J. Augustine, M.S. (l98l) Thesis title Characteristics and mechanisms of clonidine withdrawal in

normotensive and hypertensive rats A.T. Hamed, Ph.D. (l98l) Dissertation title: Pharmacological significance of cardiovascular dopamine receptors R. J. Barrett, Ph.D. (l982) Dissertation title: Role of sympathetic nervous system dopamine receptors in the

cardiovascular actions of lergotrile and pergolide E. J. Peter, M.S. (l984) Thesis title: Pharmacological analysis of the actions of calcium entry blockers

felodipine, nifedipine and verapamil: Interactions with pre and postsynaptic alpha adrenoceptors.

S. Sengupta, M.S. (1985) Thesis title: Pharmacological characterization of the cardiovascular actions of

dopamine receptor agonists, fenoldopam and quinpirole in rats. M. H. Sabouni, Ph.D. (1986) Dissertation title: Pharmacological characterization of dopamine receptors in the

sympathetic ganglia G. Kavukondala, M.S. (1986) Thesis title: The role of Na+-K+-ATPase in the regulation of sympathetic neuro-

effector function in the isolated perfused rat kidney S. S. Hegde, Ph.D. (1990) Dissertation title: Renal dopamine in the regulation of sodium and water excretion during

acute volume expansion S. J. Vyas, Ph.D. (1992) Dissertation title: Involvement of tubular DA-1 receptors in the natriuretic and diuretic

responses to dopamine and dopexamine: Role of Phospholipase-C in cellular signaling events

C. J. Chen, M.D. Ph.D. (1992) Dissertation title: Dopamine receptor- coupled cellular signaling mechanisms in renal

proximal tubules of spontaneously hypertensive rats S. Gopalakrishnan, M.S. (1994) Thesis title: Alpha-1 adrenoceptors in the renal proximal tubules: Characterization

and cellular signaling mechnisms

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U. Venkatakrishnan, M.S. (1994) Thesis title: The role of nitric oxide in the diuretic and natriuretic responses to

dopamine-1 receptor activation V. Kansra, M.S. (1995) Thesis title: Dopamine stimulates protein kinase C activity in normotensive but not

in hypertensive rats M. Bharatula, M.S. (1996) Thesis title: Characterization of Angiotensin Type I (AT1) Receptor Subtypes in the

Biphasic Effect of Angiotensin II on Renal Proximal Tubular Sodium Potassium ATPase

V. Kansra, Ph.D. (1997) Dissertation title: Renal dopamine receptor signaling mechanisms in Fisher 344 old rats S. Beheray, Ph.D. (1999) Dissertation title: Age related alterations in dopamine receptor-mediated signaling

pathways in renal proximal tubules M. Becker M.S. (1999)

Alterations in angiotensin II receptor mediated signaling pathways in the renal proximal tubules of obese Zucker hypertensive rats

V. Narkar Ph.D. (2002) Dissertation title: Dopamine D2 receptor signaling and function in renal proximal

tubules M. Menezes M.S. (2002) Thesis title: Alterations in dopamine D2-like receptor signaling mechanisms in

renal proximal tubules of Fischer 344 rats. M. Trivedi Pharm.D. / Ph.D. (2004) Renal dopamine receptor dysfunction in obese Zucker rats. A. Marwaha Ph.D. (2005)

Renal dopamine D1 receptor function in hyperglycemia associated oxidative stress

R. Fardoun Pharm.D. / Ph.D. (2006) Cellular mechanisms of oxidative stress-induced defective renal dopamine D1 receptor function A. B. Muhammad Ph.D. (2010)

Effect of exercise and caloric restriction on renal dopamine D1 receptor function in obese Zucker rats.

L. George Pharm.D. / Ph.D. (2010)

Mechanism of exercize-mediated restoration of renal dopamine D1 receptor function in aging.

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S. Bhatt Ph.D. (2011) Vascular oxidative stress in hyoertension G. Chough Ph.D. (2011)

Role of age-associated oxidative stress in altered renal D1 and AT1 receptor fuhctions and hypertension.

A. Javedhkar Ph.D. (2011) Oxidative stress and renal AT1 receptor function during hypertension. POSTDOCTORAL FELLOWS AND RESEARCH FACULTY Dr. R. D. Ekas 1978-1982 Dr. D. C. Eikenburg 1979-1981 Dr. A. L. Jadhav 1981-1988 Dr. S. Tachikawa 1981-1982 Dr. J. L. Montastruc 1982 Dr. H. O. Watkins 1982-1990 Dr. A. F. Ansari 1984-1985 Dr. G. D. Adjei 1984 Dr. A. T. Hamed 1985 Dr. M. L. DeFeo 1986-1987 Dr. T. Sakamoto 1991-1992 Dr. A. T. Hamed 1992-1993 Dr. C. J. Chen 1992-1994 Dr. T. Hussain 1995-2001 Dr. M. Asghar 1999-present Dr. L. Zhang 2001-2002 Dr. A. Banday 2001-present Dr. A Marwaha 2005-2006

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GRANT & CONTRACTS

Studies on the mechanisms of antihypertensive action of various beta adrenergic blocking agents From: New Research Opportunities Program University of Houston $4,518; 1/1/76 to l2/31/76 Studies on the functional role of presynaptic beta adrenergic receptor mechanism in sympathetic neurtoransmission From: Pharmaceutical Manufacturers Association Foundation Washington, DC $10,000; 1/1/77 to 12/31/78 Vascular reactivity in experimental hypertension From: American Heart Association; Texas Affiliate, Inc. Austin, Texas $12,685; 7/l/78 to 6/30/79 Presynaptic regulatory mechanisms in hypertension From: National Heart, Lung and Blood Institute; National Institutes of Health Bethesda, MD $194,242; 7/l/78 to l2/31/82 The role of sympathetic nervous system in the cardiovascular actions of dopaminergic agents From: Eli Lilly & Co. Indianapolis, Indiana $7,l75; 7/1/81 to 6/30/84 Studies on the role of central nervous system in the cardiovascular actions of pergolide From: Limited Grants-in-Aid Program University of Houston-University Park $600; 6/1/82 to 8/31/82

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Presynaptic dopamine receptors and sympathetic function From: National Heart, Lung & Blood Institute; National Institutes of Health Bethesda, MD $146,692; 8/l/80 to 7/31/85 Cardiovascular actions of LY-l4l865 From: Eli Lilly & Co. Indianapolis, Indiana $3,850; 7/1/84 to 6/30/8 Cardiovascular dopamine pharmacology From: Smith Kline & French Laboratories Philadelphia, PA $4,000; 4/1/85 to 3/31/86 Travel Award to attend the Asian Congress of Pharmacology, New Delhi, India From: Provost's Office University of Houston-University Park $1,000; 1/1/85 to 3/31/85 Program for Stimulation of Research Careers in the Pharmaceutical Sciences From: AACP Bethesda, Maryland $13,475; 4/1/85 to 3/31/86 Symposium on Dopaminergic Systems in Hypertension Gent, Belgium. September 8-9, 1986 From: Smith Kline and French Laboratories,Philadelphia, PA $6,500 From: Eli Lilly and Company, Indianapolis, Indiana $750 From: Rhone Poulenc Sante, Paris, France $1,000 From: Abbott Laboratories,Chicago, Illinois $500 Pathogenesis of Hypertension From: NHLBI Minority School Faculty Development Award for Dr. Arun L. Jadhav $4,500; 9/1/85 to 8/30/90

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Directed Research Career Development Program for Pharmacy Students From: AACP Bethesda, Maryland $20,130; 5/1/86 to 8/31/87 Evaluation of dopamine receptor function in spontaneously hypertensive rats following chronic treatment with agonists From: Eli Lilly & Co. Indianapolis, Indiana $6,468; 1/1/87 to 12/31/88 Role of Dopamine in Urinary Sodium Excretion From: University of Houston/BRSG $5,000; 4/l/87 to 3/31/88 Cardiovascular Effects of Liposomal Encapsulated PGE-1 in Rats From: Liposome Technology, Inc. Menlo Park, CA $5,000; 4/1/88 to 3/31/89 Selective Dopamine Receptor Agonists in the Treatment of Genetic Hypertension in Rats From: NHLBI Minority School Faculty Development Award for Dr. Halcyon O. Watkins $146,305; 4/1/88 to 3/31/93 Autoradiographic, Biochemical and Pharmacological Studies on the Dopamine-1 Receptors in the Cardiovascular System with Fenoldopam From: Smith Kline and French Laboratories King of Prussia, PA $10,000; 6/1/88 to 5/31/89 Role of Kidney Dopamine in the Natriuretic Response to Acute Volume Expansion: Potential Interactions with ANF (Schering Predoctoral Fellowship for S. S. Hegde) From: Schering Corporation Bloomfield, NJ $32,000; 9/1/88 to 8/31/90 Characterization of the Renal Effects of Dopexamine From: Fisons Pharmaceuticals Leicestershire, England $47,000; 1/1/89 to 12/31/90 Biochemical Neuropharmacology

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From: Baylor College of Medicine Houston, TX $25,000; 1/1/89 to 12/31/92 Autoradiographic and Functional Studies on Dopexamine From: Fisons Pharmaceuticals Leicestershire, England $25,000; 2/1/89 to 1/31/91 Effects of Dopexamine on Myocardial Contractility in Hemorrhagic Shock From: Fisons Pharmaceuticals Leicestershire, England $60,000; 1/1/90 to 12/31/91 Biochemical Studies on Dopexamine From: Fisons Pharmaceuticals Leicestershire, England $12,000; 1/1/90 to 12/31/91 Symposium on Significance of Peripheral Dopaminergic System in Cardiovascular and Renal Function. Essen, West Germany, July 8-10, 1990 From: Fisons plc, Leicestershire, England $15,000 From: Simes Cardiovascular Resarch Center, Milan, Italy $10,000 From: E. Merck & Co., West Germany $3,000 From: Syntex Research $1,000 From: Smith Kline & French Laboratories, Swedeland, PA $500 Autoradiographic Localization of Dopexamine Binding in the Human Cardiovascular System From: Fisons Pharmaceuticals Leicestershire, England $54,000; 1/1/90 to 12/31/91 Schering-Plough Support for Predoctoral Training Program in Pharmacology From: Schering Corporation

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Bloomfield, NJ $15,000; 9/1/90 to 8/31/91 Interactions Between Norepinephrine-Dopexamine in Affecting Renal Function From: Fisons Pharmaceuticals Leicestershire, England $10,000; 1/1/91 to 12/31/91 Effect of Dopexamine on Mesenteric Circulation During Hemorrhagic Shock From: Fisons Pharmaceuticals Leicestershire, England $60,000; 1/1/91 to 12/31/92 Autoradiographic Localization of Dopexamine Binding in the Human Intestinal Vessels From: Fisons Pharmaceuticals Leicestershire, England $40,000; 1/1/91 to 12/31/92 Schering-Plough Support for Predoctoral Trainee in Pharmacology From: Schering Corporation Bloomfield, NJ $55,000; 9/1/91 to 8/31/95 Influence of Bradykinin Receptor Antagonist on the Cardiovascular and Renal Effects of Angiotensin II Receptor Antagonist and Ramipril From: Hoechst-Roussel Pharmaceuticals, Inc. Sommerville, NJ $30,000; 3/1/92 to 2/28/93 Influence of Dopexamine on Cardiovascular Toxicity Produced by Xanthine and Xanthine Oxidase From: Fisons Pharmaceuticals Leicestershire, England $25,000; 4/1/92 to 3/31/93 Influence of Angiotensin Converting Enzyme Inhibition and Receptor Blockade on the Renal Effects of Fenoldopam From: Merck Sharp & Dohme Research Laboratories West Point, PA $20,000; 11/1/92 to 10/31/93 Provision of Pharmaceutical Care in Texas Prisons From: Texas Department of Criminal Justice,Austin, TX $1,405,877; 9/1/92 to 8/31/93 Provision of Pharmaceutical Care in Texas Prisons

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From: Texas Department of Criminal Justice, Austin, TX $1,479,781; 9/1/93 to 8/31/94 Co-Operative Research In New Drug Discovery & Delivery From: M.D. Anderson Cancer Center Houston, Tx $65,000; 9/1/93 to 8/31/96 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $1,289,868; 9/1/94 to 8/31/95 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $1,465,380; 9/1/95 to 8/31/96 Sixth International Conference on Peripheral Dopamine Camerino, Italy. June 28-July 1, 1996. From: Roche Bioscience, Palo Alto, CA. $1000 From: Merck & Co, Inc. West Point, PA $3145 From: SmithKline Beecham, King of Prussia, PA $1000 From: Zambon Group, Milan, Italy $3500 From: University of Camerino, Camerino, Italy $5000 From: Sandoz, Italy $2000 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $1,682,652; 9/1/96 to 8/31/97 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $1,698,110; 9/1/97 to 8/31/98 Kidney Dopamine Receptor Function in Old Rats (AG 15031) From: National Institute on Aging; National Institutes of Health

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Bethesda, MD $ 997,267; 7/1/98 to 12/31/03 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $1,752,481; 9/1/98 to 8/31/99 Provision of Pharmaceutical Care in Texas Prisons From: UTMB Managed Care, Galveston, Tx. $755,339; 9/1/99 to 3/12/00 Renal Dopamine Receptor Function in Obese Zucker Rats (DK 58743) From: National Institute of Diabetes, Digestive and Kidney Diseases; NIH Bethesda, MD $ 895,000; 03/01/01 to 01/31/06 Kidney Dopamine Receptor Function in Old Rats (AG 15031-04S1) From: National Institute on Aging; National Institutes of Health Bethesda, MD $ 79,176; 09/01/03 to 12/31/04 AFPE Pre-Doctoral Fellowship for Meghna Trivedi From: American Foundation for Pharmaceutical Education Rockville, MD $6,000.00; 09/01/03 to 08/31/04 Age-Related Changes in Renal Dopamine Receptor Function (AG 25056) From: National Institute on Aging; National Institutes of Health Bethesda, MD $ 1,485,000; 08/1/05 to 07/31/11 Renal Dopamine and Angiotensin II Receptor Function in Age-Related Hypertension From: National Institute on Aging; National Institutes of Health Betheda, MD $ 1, 875,000; 09/01/11 to 08/31/16 Role: Co-Investigator PI: Dr. Mahammad Asghar

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COMMITTEE SERVICE Department Member, Graduate Education Committee, Department of Pharmacology, College of Pharmacy, University of Houston (1978-1980). Chairman, Graduate Education Committee, Department of Pharmacology, College of Pharmacy, University of Houston (1980-1991). College Member, Admissions Committee, College of Pharmacy, University of Houston (1976-1978). Member, Library Committee, College of Pharmacy, University of Houston, (1976-1990). Member, Graduate Studies Committee, College of Pharmacy, University of Houston (1979-1981) Member, Ad Hoc Curriculum Revision Committee, College of Pharmacy, University of Houston (1979-1980). Member, Executive Committee, College of Pharmacy, University of Houston (1980-1991). Member, Accreditation Self-Study, College of Pharmacy, University of Houston (1985-1988). Chair, Executive Council, College of Pharmacy, University of Houston (1991-2002). Chair, Task Force on TMC Building Annex, College of Pharmacy, University of Houston(2003-present) University Member, Research Council, University of Houston (1983-1986). Chairman, Biomedical Research Support Grant Subcommittee, University of Houston (1983-1986). Member, Internal Grants Program Subcommittee, University of Houston (1983-1984). Member, Advisory Committee for International Affairs, University of Houston (1985-1986). Member, Ad-Hoc Resarch Award Committee, University of Houston (1986-1987).

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Member, Academic Council, University of Houston (1988-1991). Member, Biomedical Research Support Grant Subcommittee, University of Houston (1989). Member, Nominating Committee, Sigma Xi Scientific Research Society (1988-1991). Member, Dean's Council (1991-2002) Task Force on Faculty/Staff Merit Salary Increase (1994-95) Task Force on HEAF Allocations (1994-95) Task Force on Research Priorities (1995-96) Task Force on Faculty Workload (1995-96) Task Force on University Development (1995-96) Task Force on Faculty Development (1996-97) Task Force on Faculty Reward Systems (1996-97) Member, Search Committee, Director of Animal Care Operations (2004-2005) External Member, Executive Committee, Texas Pharmacologists, 1980-1992. Member, Texas Pharmacy Congress, 1991-2002 Member, Policy Council, Texas Medical Center, 1991-2002 Delegate, Council of Deans, American Association of Colleges of Pharmacy, 1991-2002 Member, Long Range Planning Committee, Texas Pharmaceutical Association, 1991-1993. Member, President's Advisory Committee, Texas Society of Hospital Pharmacists, 1991-1993. Member, Faculty Advisory Committee, Owen Healthcare, Inc. 1992-2000. Member, Research Conflict of Interest Oversight Committee, UT Health Science Center-Houston 2003-present CONTINUING EDUCATION SEMINARS Mechanism of Action of Peripherally Acting Antihypertensive Agents. In: Continuing Education Short Course on Hypertension and its Treatment,Wichita Falls, Texas, October, 1975. Mechanism of Action and Therapeutic Uses of Some Newer Centrally Acting Antihypertensive Agents. In: Continuing Education Short Course on New Concepts in Drug Therapy, Houston, Texas, November 1976. Morphine and Related Narcotics. In: Continuing Education Short Course on Drugs of Abuse, Houston, Texas, March 1978.

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Hypertension: Pathophysiology and Treatment In: Continuing Education Short Course on Current Concepts in the Treatment of Cardiovascular Disease, Houston, Texas, March 1980. Calcium Antagonists. In: Continuing Education Short Course on Clinical Pharmacology of Selected Therapeutic Agents, Houston, Texas, November 1981. Calcium Antagonists in the Treatment of Hypertension. In: Continuing Education Short Course on Hypertension and Antihypertensive Agents, Houston, Texas, October 1984. Etiology and Pathogenesis of Hypertension. In: Continuing Education Short Course on New Concepts and New Drugs in Cardiovascular Diseases, Beaumont, Texas, November, 1985. Angiotensin Converting Enzyme Inhibitors and Calcium Antagonists in Cardiovascular Disease. In: Continuing Education Short Course on New Concepts and New Drugs in Cardiovascular Diseases, Beuamont, Texas, November, 1985. Pathophysiology of Hypertension. In: A Symposium on Hypertension in Blacks: Pathophysiology and Treatment, Houston, Texas, October, 1986. New Drug Discovery and Premarketing Evaluation of Drugs. May, 1995. New Drugs for 1994. June, 1995. SOCIETY MEMBERSHIPS American Association for the Advancement of Science American Society for Pharmacology and Experimental Therapeutics Member, Committee on Public Affairs (1995-01) Chair, Committee on Public Affairs (1996-01) Member, Public Affairs Advisory Committee, FASEB (1996-99) Member, Science Policy Committee, FASEB (1999-02) Society for Experimental Biology and Medicine International Society of Hypertension Abstract Reviewer: Sixth Scientific Meeting, Heidelberg, Germany Abstract Reviewer: Sixteenth Scientific Meeting, Glasgow, Scotland Abstract Reviewer, Seventeenth Scientific Meeting, Amsterdam, The Netherlands Fellow, Council for High Blood Pressure Research, American Heart Association Council on Basic Science, American Heart Association American Association of Colleges of Pharmacy Member, Committee on Faculty Enterpreunership (1994-96) Member, Finance Committee (1995-96) Member, International Pharmaceutical Education Advisory Committee (2001-02) Rho Chi Fellow, American Society of Nephrology Member, Program Committee, 2001 World Congress of Nephrology Sigma Xi, The Scientific Research Society Inter-American Society of Hypertension Texas Pharmacy Association Member, 1996 Pharmacist of the Year Selection Committee Trustee, Texas Pharmacy Foundation (1996-97)

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Texas Society of Health-Systems Pharmacists The American Society of Hypertension American Society of Health-Systems Pharmacists Society for Free Radical Biology and Medicine, Abstract Reviewer (2003, 2004, 2006) The American Society for Cell Biology ORGANIZATION OF MEETINGS AND SYMPOSIA Member, Organizing Committee, Fall Meeting of the American Society for Pharmacology and Experimental Therapeutics, Houston, TX 1978. Chairman, Organizing Committee, Sixth Annual Meeting of Texas Pharmacologists, Houston, TX 1980. Member, Organizing Committee, Annual Meeting of Scientists of Indian Origin, Society for Neuroscience, Dallas, TX 1983. Co-Organizer, Symposium on Dopaminergic Systems in Hypertension, Gent, Belgium 1986. Co-Organizer, Scientific Program, Thirteenth Annual Meeting of Texas Pharmacologists, Galveston, TX 1989. Co-Organizer, Annual Meeting of the S.W. Section of the Society for Expermental Biology & Medicine, Houston, TX 1989. Co-Organizer, Symposium on Significance of Peripheral Dopaminergic System in Cardiovascular and Renal Function, Essen, West Germany 1990. Co-Organizer, Symposium on New Cardiovascular Drugs, Acapulco, Mexico 1991. Member, Advisory Committee, 5th International Conference on Peripheral Dopamine, Kyoto, Japan, 1994. Member, Scientific Committee, Interaction in the Practice of Internal Medicine and Endocrinology, Capri, Italy, 1994. Co-organizer, 6th International Conference on Peripheral Dopamine, Camerino, Italy, 1996. Member, Planning Committee, USP South Regional Meeting, Houston, Tx., 1997. Chairman, International Scientific Advisory Committee, Symposium on Emerging Trends in Diabetes and Hypertension, Ahmedabad, India, 1997. Co-organizer, Symposium on The Role of Renal Dopamine Receptors in Hypertension at the EB’99 Meeting in Washington, D.C. April, 1999. Member, Scientific Program Committee, 8th International Conference on Peripheral Dopamine, Stockholm, Sweden, June, 2002. Member, International Scientific Committee, Pan Arab Congress of Pharmacology, Fez, Morocco, September, 2002.

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Member, International Advisory Board, 9th National Conference on Bioactive Heterocycles and Drug Discovery Paradigm, Rajkot, India, January, 2005. INVITATIONS TO NATIONAL & INTERNATIONAL MEETINGS International Symposium on Central Actions of Angiotensin and Related Hormones, Houston, TX, January 1976. International Symposium on Hypertension and Antihypertensive Agents, Texas Medical Center, Houston, TX, October 1977. Symposium on Dopamine Receptor Mechanisms, The New York Academy of Sciences, New York, NY, May 1979. International Symposium on Central Nervous System Mechanisms in Hypertension, Houston, TX, May 1980. Symposium on Receptor Mechanisms in Pharmacology, Puerto Vallarta, Mexico, January 1983. First Smith Kline & French Laboratories Annual Research Symposium on Dopamine Receptor Agonists, Philadelphia, PA. February 1983. Symposium on Calcium Channel Blockers, Asian Congress of Pharmacology, New Delhi, India, January 1985. International Symposium on Chemical Modulation of Neural Function, Calcutta, India, January 1985. Symposium on The Role of Peripheral Dopamine Receptors in Cardiovascular Function, FASEB Meeting, Anaheim, CA, April 1985. Symposium on Brain Peptides and Catecholamines in Cardiovascular Regulation in Normal and Disease States, Houston, TX., January, 1986. Symposium on CNS Actions of Dopamine, Texas Pharmacologists Meeting, Galveston, TX., May, 1986. Symposium on Dopaminergic Systems in Hypertension, Gent, Belgium, September, 1986. Fifth Capo Boi Conference on Neuroscience, Symposium on Similarities and Dissimilarities Between Central and Peripheral Dopamine Receptors, Villasimius, Sardinia, Italy, May, 1987. Symposium on Peripheral Actions of Dopamine, Melbourne, Australia, August, 1987. Department Chairmen's Symposium, Texas Pharmacologists, Austin, TX., June, 1988.

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Symposium on Receptors and Signal Transduction, Southwestern Section of Society for Experimental Biology and Medicine, Dallas, TX., November, 1988. Symposium on Dopamine Receptors and Pharmacotherapy of Heart Failure, Rottach-Eagern, West Germany, July, 1989. Seventh Meeting on Adrenergic Mechanisms, Porto, Portugal, October, 1989. 3rd International Symposium on Peripheral Actions of Dopamine, Charlottesville, VA., October, 1989. Symposium on Ibopamine: New Pharmacotherapeutic Approach to Heart Failure, Kyoto, Japan, October, 1989. Dopaminergic Agents in Vital Organ Perfusion, Amsterdam, The Netherlands, June, 1990. Dopacard Workshop: Toward Improving Vital Organ Perfusion, Stockholm, Sweden, June, 1990. Satellite Symposium on Significance of Peripheral Dopaminergic System in Cardiovascular and Renal Function, Essen, West Germany, July, 1990. 11th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, March, 1991. Symposium on Renal Actions of Dopexamine Hydrochloride, Brussels, Belgium, March, 1991. Symposium on Improving Vital Organ Function - The Role of Dopexamine Hydrochloride, Montreux, Switzerland, September, 1991. Symposium on Regional Blood Flow, London, England, November, 1991. ISH - Workshop on Hypertension and Receptors, Amsterdam, The Netherlands, November, 1991. XXIVth Annual Meeting of Indian Pharmacological Society, Ahmedabad, India, December, 1991. 5th Annual Meting of the Indo-American Pharmaceutical Society, New York, N.Y. April, 1992. 4th International Conference on Peripheral Dopamine, Porto, Portugal, June, 1992. 7th International Catecholamine Symposium, Amsterdam, The Netherlands, June, 1992. 113th Annual Meetimg of the Texas Pharmaceutical Association, Houston, Tx. June, 1992. 7th Annual Region D Meeting of the Texas Pharmaceutical Association, San Antonio, Tx. April, 1993. Interactions in the Practice of Internal Medicine and Endocrinology, Capri, Italy, September, 1994.

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5th International Coference on Peripheral Dopamine, Kyoto, Japan, October, 1994. Renal Dopaminergic Mechanisms in Hypertension, Sapporo, Japan, October, 1994. American Association of Colleges of Pharmacy : Isuues of State Funding for Education and Research, Washington,D.C. March, 1995. 15th Internatinal Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, March, 1995. Texas Society of Health-Systems Pharmacists: Panel Discussant, Corpus Christi, Texas, April, 1996. 6th International Conference on Peripheral Dopamine, Camerino, Italy, July, 1996. 9th Meeting on Adrenergic Mechanisms, Porto, Portugal, September, 1996. Drug Policy Forum of Texas, Houston, Tx., October, 1996. Eckerd Conference on the Future of Managing Pharmaceutical Care, Clearwater, Florida, November, 1996. FASEB Consensus Conference on Federal Funding, Washington, D.C., November, 1996. Texas Society of Health-Systems Pharmacists: Panel Discussant, Austin, Texas, April, 1997. Eckerd 2nd Annual Healthcare Summit, St.Petersburg, Florida, November, 1997 First Asia-Pacific Congress on Hypertension, Surat, India, November, 1997. Symposium on Emerging Trends in Diabetes and Hypertension, Ahmedabad, India, December, 1997. 7th International Conference on Peripheral Dopamine, Dublin, Ireland, August, 1998. 34th Scientific Meeting of the Society for the Spontaneously Hypertensive Rat, Kyoto, Japan, October, 1998. Experimental Biology ‘99 Symposium on The Role of Renal Dopamine Receptors in Hypertension, Washington, D.C. April, 1999. Acta Physiologica Scandanavica Symposium on Vasodilators in the Development of Hypertension: NO and Dopamine, Uppsala, Sweden, June, 1999. Symposium on Dopamine and Blood Pressure Regulation, 2nd European Congress of Pharmacology, Budapest, Hungary, July, 1999. 1st International Congress of Hypertension: From Pathophysiology to Treatment, Fez, Morocco, October, 1999. American Association of Colleges of Pharmacy Annual Meeting:Forum on Pharm.D./Ph.D. Programs, San Diego, CA, July, 2000.

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4th Annual Houston International Community Health Summit, Houston, Tx. September, 2000. 27th Annual Texas Federation of Drug Store Convention, Austin, Tx. October, 2001. Education Connection Conference, Rite Aid Corporation, Philadelphia, PA., November, 2001. American Association of Colleges of Pharmacy Interim Meeting, Houston, Tx. March, 2002. Partnership in Pharmacy Focus 2002 Conference, Palm Harbor, FL. April, 2002. 8th International Conference on Peripheral Dopamine, Stockholm, Sweden, June, 2002. Fourth Annual John H. Laragh Conference on Advances in Hypertension Research, The American Society of Hypertension, Coral Gables, FL. January, 2003. Biology of the Aging Kidney Workshop, National Institute on Aging, Bethesda, MD, January, 2003. Seventh Annual Diabetes Conference, The SMi Group, London, England, October, 2005 The Biology of Aging, Gordon Research Conference, Ventura, CA, February, 2006. The 12th International SHR Symposium, Kyoto, Japan, October, 2006 The 13th Innternational SHR Symposium, Prague, the Czec Republic, June, 2008 Symposium on R alpha lipoic acid, Rome, Italy, September, 2010. INVITATIONS FOR SEMINARS Division of Gynecology, Memorial Hospital, Houston, TX, April 1977. Department of Neurology, New York University Medical Center, New York, NY, May 1979. Department of Pharmacology, New Jersey College of Medicine and Dentistry, Newark, NJ, May 1979. Department of Pharmacology, University of Kentucky, College of Medicine, Lexington, KY, June 1979. Department of Pharmacology, Smith Kline Corporation, Philadelphia, PA, January 1981.

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Department of Biology, Synthelabo, L.E.R.S., Paris, France, June 1981. Department of Pharmacology, Texas College of Osteopathic Medicine, Ft. Worth, TX, June 1982. Department of Pharmacology, Smith Kline Corp., Philadelphia, PA, June 1982. Department of Cardiovascular Pharmacology. Eli Lilly & Co., Indianapolis, IN, November 1982. Department of Pharmacology, Syntex Research, Palo Alto, CA, June 1983. Department of Biology, Texas Southern University, Houston, TX, February 1984. Division of Cardiology, St. Luke's Episcopal Hospital & Texas Heart Institute, Houston, TX, March 1984. Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad, India, January 1985. Department of Pharmacology, College of Medicine & Dentistry, Newark, NJ, March 1985. Department of Cardiovascular Pharmacology, Ayerst Research Laboratories, Princeton, NJ, August 1985. Department of Cardiovascular Research, Rhone-Poulenc Sante, Paris, France, September, 1986. Department of Physiology, University of Goteborg, Goteborg, Sweden, September, 1986. Houston Pharmacological Center, UT Medical School, Houston, TX, April, 1987. Department of Biology, Prairie View A&M University, Prairie View, TX, September, 1987. Department of Pharmacology, Schering Corporation, Bloomfield, NJ, November, 1987. Department of Neuroscience, University of Rome, Rome, Italy, December, 1987. Division of Endocrinology, University of Florence, Florence, Italy, December, 1987. Liposome Technology, Inc., Menlo Park, CA, February, 1988. Department of Pharmacology, Squibb Institute for Medical Research, Princeton, NJ, March, 1988. Department of Pharmacology, Berlex Laboratories, Cedar Knoll, NJ, March, 1989. Department of Pharmacology, Smith Kline & French Laboratories, Swedeland, PA, June, 1989. Cardiovascular Research Group, Simes Laboratories, Zambon Corporation, Milan, Italy, July, 1989. Institute of Pharmacology, Erasmus University, Rotterdam, The Netherlands, June, 1990.

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Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX, May, 1991. Division of Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, June, 1991. Department of Cardiovascular and Respiratory Science, University of Rome-La Sapienza, Rome, Italy, October, 1991. Department of Intensive Care, Erasme University Hospital, Brussels, Belgium, December, 1991. Indian Medical Association, Palanpur, India, December, 1991. Department of Pharmacology, University of Texas Medical Branch at Galveston, Galveston, TX, April, 1992. Division of Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX. October, 1993. Sigma Xi, The Scientific Research Society, University of Houston Chapter, Houston, TX. November, 1993. Faculty of Pharmacy, University of Camerino, Camerino, Italy. June, 1994. The Speywood Laboratories, Ltd. London, England. June, 1994. Department of Physiology, Trinity Collge Dublin, Dublin, Ireland. September, 1996. Indian Medical Association, Palanpur, India. December, 1997. Department of Pharmacology, University of California-San Diego, La Jolla, CA. August, 1998. Department of Pharmacology, Kinki University School of Medicine, Osaka, Japan, September, 1998. Graduate School of Medicine, Kinki University, Osaka, Japan, September, 1998. Department of Pharmacology, Mt. Sinai University School of Medicine, New York, NY, December, 1998. Department of Pharmacology, Molecular Pharmacology and Renal Physiology Unit, INSERM, Toulouse, France, June, 2001. Dyslipedimia Research Laboratories, Astra-Zeneca, Molndal, Sweden, June, 2002. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Tx. January, 2003. Department of Biology and Biochemistry, College of Natural Sciences and Mathematics, University of Houston, Houston, Tx. February, 2003. Faculty of Pharmacy, University of Camerino, Camerino, Italy, October, 2004.

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Washington County Rotary Club, Brenham, Tx. March, 2005. Department of Health and Kinesiology, Texas A&M University, College Station, Tx. November, 2006. School of Pharmacy, Texas Tech University Health Sciences Center Amarillo, Tx. January, 2007 Department of Pharmacology, The Third Military Medical University, Chogqing, P.R.China, March, 2007 Deprtmant of Cardiology, The Third Military Medical University, Chogqing, P.R.China, March, 2007 Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Forth Worth, TX. March, 2008 Deaprtmant of Pharmacology, University of Medicine and Dentistry of New Jersey, Newark, NJ. April, 2008. Faculty of Pharmacy, University of Camerino, Camerino, Italy, October, 2008. EXTERNAL GRANTS & OTHER REVIEWS Member: Site Visit Committee, National Institute of General Medical Sciences, NIH,

1980, 1981. Site Visit Committee, National Center for Research Resources, NIH, 1992. Member: Special Review Committee, Pharmacological Sciences , NIGMS, March, 1987.

Special Review Group, Experimental Cardiovascular Science, NHLBI, October, 1992.

Member: Scientific Advisory Committee, RCMI Program Project, Texas Southern University, 1995-2000 Proposal Reviewer: National Science Foundation, 1980, 1984, 1985, 1992, 2000. The National Kidney Foundation, 1997 Reviewer: Ph.D. Programs in Pharmacology, National Research Council, 1993. Reviewer: Developmental Research Projects, RCMI Program for Texas Southern University 1993. Evaluation Team Member: American Council on Pharmaceutical Education, 1994. Reviewer: Italian Ministry for Education University and Research, 2001-present Member: Cardiovascular and Renal Study Section, CSR/NIH

July 1, 2002 – October 31, 2003. Cellular and Molecular Biology of the Kidney Study Section, CSR/NIH

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March 1, 2004- June 30, 2006. Member: CSR/NIH, Special Emphasis Review Panel, November, 2006. Ad-hoc Member: Hypertension Microcirculation Study Section, October, 2008, January, 2009, September, 2009, June, 2010. Member: NHLBI Spring Hypertension Program Project Review Group, May, 2003 NHLBI Special Emphasis Panel Program Project Review Group, May, 2006 NHLBI Special Emphasis Panel Program Project Review Group, October, 2008 Member: Review Panel, Oklahoma Center for the Advacement of Science and Technology, April, 2007.

EDITOR-IN-CHIEF Clinical and Experimental Hypertension (1993- present) ASSOCIATE EDITOR Clinical & Experimental Hypertension (1992-1993) EDITORIAL BOARDS Clinical & Experimental Hypertension (1985-1991) Drug Development Research (1986-1992) Journal of Cardiovascular Pharmacology (1987-1998) Hypertension Research (1999-present) Experimental Biology & Medicine (2000-2005) Journal of Epithelial Biology and Pharmacology (2008-present) MANUSCRIPT REVIEWS (1975-present) Life Sciences European Journal of Pharmacology Journal of Pharmacology & Experimental Therapeutics Journal of Autonomic Pharmacology Circulation Research American Journal of Physiology : Heart & Circulatory Physiology American Journal of Physiology: Renal, Fluid & Electrolyte Physiology American Journal of Physiology: Regulatory , Imtegrative & Comparative Physiology American Journal of Physiology: Endocrinology & Metabolism American Journal of Physiology: Cell Physiology Pediatric Nephrology Hypertension Federation Proceedings Pharmacological Reviews Brain Research Bulletin Journal of Clinical Investigation Research Communications in Chemical Pathology & Pharmacology

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Journal of Pharmaceutical Sciences Archives Internationales de Pharmacodynamie et de Therapie Naunyn-Schmiedeberg's Archives of Pharmacology Circulation Circulation Research Biochemical Pharmacology Fundamental & Clininical Pharmacology Clinical Intensive Care The International Journal of Biochemistry & Cell Biology Molecular Pharmacology Pharmacology and Therapeutics American Journal of Hypertension Kidney International Journal of Neurochemistry Experimental Biology & Medicine Journal of Hypertension Cellular and Molecular Biology American Journal of Kidney Diseases Science Physiological Genomics Proceedings of the National Academy of Sciences Acta Physiologica Scandavavica British Journal of Pharmacology Neuroscience Letters Nephron Current Medicinal Chemistry-Cardiovascular and Hematological Agents Non-Linearity in Biology, Toxicology and Medicine Nature Clinical Practice Nephrology American Journal of Nephrology Journal of Aging Research

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PUBLICATIONS Books & Journals 1. Central Actions of Angiotensin and Related Hormones, Eds. J. P. Buckley and C.M.

Ferrario. Assoc. Ed. M.F. Lokhandwala, Pergamon Press, Inc., New York, 1977. 2. Central Nervous System Mechanisms in Hypertension, Eds. J. P. Buckley and C.M.

Ferrario, Assoc. Ed. M.F. Lokhandwala, Raven Press, New York, 1981. 3. Brain Peptides and Catecholamines in Cardiovascular Regulation, Eds. J. P.

Buckley and C. M. Ferrario. Assoc. Ed. M. F. Lokhandwala, Raven Press, New York 1987.

4. Proceedings of a Symposium on Dopaminergic Systems in Hypertension, Eds. M. F.

Lokhandwala, M. G. Bogaert and R. A. Lefebvre. Clinical & Experimental Hypertension, A9: 5 & 6, 1987.

5. Proceedings of Symposium on Significance of Peripheral Dopaminergic System in

Cardiovascular and Renal Function, Eds. M. F. Lokhandwala, F. Amenta and O.-E. Brodde. Journal of Autonomic Pharmacology, 10 (Suppl 1): 1990.

6. Science of Drug Action: Course Outline, Eds. T. L. Lemke and M. F. Lokhandwala,

Kendall/Hunt Publishing Co., Dubuque, Iowa, 1990. 7. Principles of Drug Action: Course Outline, Eds. K. Alkadhi, F. Bove, T. Lemke and

M. F. Lokhandwala, University of Houston, Houston,Tx. 1995. 8. Proceedings of the 6th International Conference on Peripheral Dopamine, Eds. F.

Amenta and M. F. Lokhandwala. Clinical & Experimental Hypertension, 19: 1&2, 1997.

9. Proceedings of the International Symposium on Emerging Trends in Diabetes

Mellitus and Hypertension, Eds. R.K. Goyal and M.F. Lokhandwala. Clinical & Experimental Hypertension, 21: 1&2, 1999.

10. R(+) Dalla Ricerca Di Base Alle Applicazioni Cliniche Dell’enantiomero Naturale

Di Un Antiossidante Multifunzione, Eds. A. Amenta, V. Costigliola and M.F. Lokhandwala. Pacine Editore S.p.A., Pisa, Italy, 2010.

Book Chapters 1. Lokhandwala, M.F. and Buckley, J.P.: Studies on the interactions of clonidine with

the hypertensive activity of angiotensin II, In: Central Actions of Angiotensin and Related Hormones, Eds. J.P. Buckley and C.M. Ferrario, Pergamon Press, New York, 215-224, 1977.

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2. Buckley, J.P., Vollmer, R.R. and Lokhandwala, M.F. and Jandhyala, B.S.: Drug actions on cardiovascular dynamics, In: Cardiovascular Flow Dynamics and Measurements, Eds. N.G.C. Hwang and N.A. Norman, University Park Press, Baltimore, 73l-756, 1977.

3. Buckley, J.P., Saelens, D., Lokhandwala, M.F. and Jandhyala, B.S.: Central actions

of angiotensin II in dogs, In: Essential Hypertension, Ed. R.H. Thurm, Year Book Medical Publishers, Chicago, 299-315, 1979.

4. Buckley, J.P., Lokhandwala, M.F., Jandhyala, B.S., Francis, J.S. and Tadepalli, A.S.:

Circulatory effects of chronic intraventricular administration of angiotensin II in dogs, In: Central Nervous System Mechanisms in Hypertension, Eds. J.P. Buckley and C.M. Ferrario, Raven Press, New York, 363-375, 1981.

5. Eikenburg, D.C., Ekas, R.D. and Lokhandwala, M.F., Presynaptic modulation of

norepinephrine release by a-adrenoceptors and angiotensin II receptors in spontaneously hypertensive rats, In: Central Nervous System Mechanisms in Hypertension, Eds. J.P. Buckley and C.M. Ferrario, Raven Press, New York, 215-228, 1981.

6. Lokhandwala, M.F. and Barrett, R.J.: Pharmacological role of presynaptic dopamine

receptors in the Cardiovascular Actions of Dopaminergic Agents, In: Central Nervous System Mechanisms in Hypertension, Eds. J.P. Buckley and C.M. Ferrario, Raven Press, New York, 203-213, 1981.

7. Jandhyala, B.S., Saelens, D., Lokhandwala, M.F. and Buckley, J.P.: Cardio-vascular

effects of chronic administration of angiotensin II into cerebrolateral ventricles of dogs, In: Hypertension, Ed. H. Villarreal, John Wiley and Sons, Inc. New York, 209-218, 1981.

8. Buckley, J.P., Jandhyala, B.S. and Lokhandwala, M.F.: Effects of central angiotensin

on renin release from the kidney, In: The Renin Angiotensin System in the Brain, Eds. D. Ganten, M.P. Printz and M.I. Phillips, Springer-Verlag, New York, 365-372, 1982.

9. Lokhandwala, M.F. and Barrett, R.J.: Dopamine receptor agonists and hypertension,

In: Dopamine Receptor Agonists, Eds. G. Poste and S.J. Crooke, Plenum, New York, 209-223, 1984.

10. Eikenburg, D. C., Peter, E. J. and Lokhandwala, M. F.: Effects of calcium channel

blockers on pre- and post-junctional noradrenregic mechanisms in the isolated perfused rat kidney. In: Proceedings of the Asian Congress of Pharmacology, Ed. B. N. Dhawan, Allied Publishers, New Delhi, India, 1986.

11. Lokhandwala, M. F.: Dopamine receptor agonists and cardiovascular neuroeffector

function, In: Brain Peptides and Catecholamines in Cardiovascular Regulation, Eds. J. P. Buckley and C. M. Ferrario, Raven Press, New York, NY, 65-77, 1987.

12. Lokhandwala, M. F., DeFeo, M. L. and Cavero, I: Physiological and pharmacological

significance of dopamine receptors in the cardiovascular system, In: Progress in Hypertension (Vol. I); Neurotransmitters as Modulators of Blood Pressure, Ed. H. Saito, VSP, Zeist, The Netherlands, 115-144, 1988.

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13. Lokhandwala, M. F.: Identification of two distinct subtypes of dopamine receptors in sympathetic ganglia, In: Symposia in Neuroscience, Eds. G. Biggio, P. F. Spano, G. Toffano and G. L. Gessa, Liviana Press-Springer Verlag, 15-21, 1988.

14. Lokhandwala, M. F. and DeFeo, M. L.: Neuronal dopamine receptors, In: Peripheral

Actions of Dopamine, Ed. C. Bell and B. McGrath, McMillan, 153-171, 1988. 15. Lokhandwala, M. F. and Hegde, S. S.: Cardiovascular pharmacology of dopamine

receptor agonists, In: Peripheral Dopamine Pathophysiology, Ed. F. Amenta, CRC Press Inc., Boca Raton, Florida, 63-77, 1990.

16. Lokhandwala, M.F.: Role of kidney dopamine in sodium excretion, In: Peripheral

Dopamine Pathophysiology, Ed. F. Amenta, CRC Press Inc., Boca Raton, Florida, 79-85, 1990.

17. Lokhandwala, M. F., Sabouni, M. H. and Alkadhi, K. A.: Cardiac and vascular

consequences of modulation and sympathetic neurotransmission by dopaminergic agonists, In: The Cardiovascular Function of Peripheral Dopamine Receptors, Ed. J. P. Hieble, Marcel Dekker, New York, NY, 133-149, 1990.

18. Lokhandwala, M. F.: Effects of dopamine receptor agonists on cardiovascular and

renal function, In: Updates in Intensive Care and Emergency Medicine, Ed. J. L. Vincent, Springer-Verlag, 74-80, 1991.

19. Chen, C. J., Vyas, S. J., Eichberg, J., Beach, R. E. and Lokhandwala, M. F.:

Abolished DA-1 receptor mediated inhibition of renal tubular Na+,K+-ATPase in spontaneously hypertensive rats, In: Genetic Hypertension, Ed. J. Sassard, John Libbey Eurotext, 463-465, 1992.

20. Chen C. J. and Lokhandwala, M. F.: Impairment of renal dopamine receptor function

in spontaneously hypertensive rats. In: Advances in the Biosciences Volume 88 ; Cardiovascular and Renal Actions of Dopamine. Ed. P. Soares-da-Silva , Pergamon Press, Oxford, 143-154, 1993.

21. Lokhandwala, M. F.: Role of kidney dopamine and dopamine receptors in the

regulation of sodium excretion. In: Experimental Cardiology, Ed.C. Casagrande, CnM Edizione Scientifiche, Coromano, Italy, 119-133, 1993.

22. Lokhandwala, M.F. and Chen, C.J.: Peripheral dopamine receptors, In: Peripheral

Dopamine Receptor Function and Pharmacology, Ed. H.B. Niznik, Marcell Dekker, Inc. New York, 89-92,1994.

23. Lokhandwala, M.F., Jandhyala,B.S. and Jacinto S.M.: Dopaminergic drugs in

cardiovascular emergencies, In: Yearbook of Intensive Care and Emergency Medicine, Ed. J.L.Vincent, Springer-Verlag, 945-954, 1995.

24. Lokhandwala, M.F.: Acido tioctio: farmacologia ed applicazioni terapeutiche di un

antiossidante particolare. In: R(+) Dalla Ricerca Di Base Alle Applicazioni Cliniche Dell’enantiomero Naturale Di Un Antiossidante Multifunzione, Eds. A. Amenta, V. Costigliola and M.F. Lokhandwala. Pacine Editore S.p.A., Pisa, Italy, 2010.

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Review Articles 1. Lokhandwala, M.F.: Presynaptic receptor systems on cardiac sympathetic nerves. Life

Sci. 24:l823-l832, l979. 2. Lokhandwala, M.F. and Barrett, R.J.: Cardiovascular dopamine receptors:

Physiological Pharmacological and Therapeutic implications, J. Autonomic Pharmacol. 3:l89-215, l982.

3. Lokhandwala, M.F. and Eikenburg, D.C.: Presynaptic receptors and alterations in

norepinephrine release in spontaneously hypertensive rats, Life Sci. 33:1527-1542, 1983.

4. Lokhandwala, M.F. and Barrett, R.J.: Dopamine receptor agonists in cardiovascular

therapy, Drug Develop. Res. 3:299-310, l983. 5. Eikenburg, D. C. and Lokhandwala, M. F.: Calcium antagonists and sympathetic

neuroeffector function, J. Autonomic Pharmacol. 6: 237-255, 1986. 6. Lokhandwala, M. F.: Preclinical and clinical studies on the cardiovascular effects of

fenoldopam, a DA-1 receptor agonists, Drug Develop. Res., 10:123-134, 1987. 7. Lokhandwala, M. F.: Cardiovascular and renal effects of dopamine receptor agonists,

ISI Atlas of Science: Pharmacology, 2:261-266, 1988. 8. Lokhandwala, M .F. and Hegde, S. S.: Cardiovascular dopamine receptors: Role of

renal dopamine and dopamine receptors in sodium excretion, Pharmacology & Toxicology, 66: 237-243, 1990.

9. Hegde, S. S. and Lokhandwala, M.F.: Renal dopamine and sodium excretion, Amer.

J. Hyperten. 3:78S-81S. 1990. 10. Lokhandwala, M. F. Renal actions of dopexamine hydrochloride, Clin. Int. Care,

1:163-174, 1990. 11. Lokhandwala, M. F., Vyas, S. J. and Hegde, S. S.: Renal dopamine and tubular DA-1

receptors in the regulation of sodium excretion. J. Auton. Pharmacol. 19(Suppl 1):S31-S39, 1990.

12. Chintala, M. S., Lokhandwala, M. F. and Jandhyala, B. S.: Protective effects of

dopexamine hydrochloride in renal failure after acute hemorrhage in dogs. J. Auton. Pharmacol. 10(Suppl 1):S95-S102, 1990.

13. Lokhandwala, M. F. and Hegde, S. S.: Cardiovascular pharmacology of adrenergic

and dopaminergic receptors: Therapeutic significance in congestive heart failure, Am. J. Med. 90(Suppl. 5B): 2S-9S, 1991.

14. Lokhandwala, M. F., Amenta, F. and Jandhyala, B. S.: Renal research on dopexamine

hydrochloride, Clin. Int. Care, 2:12-15, 1991. 15. Lokhandwala, M. F. and Amenta, F.: Anatomical distribution and function of

dopamine receptors in the kidney. FASEB Journal, 5:3023-3030, 1991.

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16. Lokhandwala, M. F. and Jandhyala, B. S.: Effects of dopaminergic agonists on organ blood flow and function, Clin. Int. Care, 3:12-15, 1992.

17. Chen, C. J. and Lokhandwala, M. F.: Dopaminergic receptors in hypertension,

Pharmacology & Toxicology, 70: s11-s16, 1992. 18. Chen, C. J. and Lokhandwala, M. F.: Dopamine receptor agonists in cardiovascular

pharmacotherpy, Indian J. Pharmacology, 24: 72-81, 1992. 19. Lokhandwala,M.F., Kansra, V. and Chen,C.J.: Dopaminergic modulation of Na,K-

ATPase activity in the proximal tubules of normotensive and hypertensive rats. Hypertension Res. 18 Suppl.I: S43-S46, 1995.

20. Hussain, T. and Lokhandwala, M. F.: Dopamine-1 receptor G-protein coupling and

the involvement of phospholipase A2 in the dopamine-1 receptor-mediated cellular signaling mechanisms in the proximal tubules of SHR. Clin. Exp. Hyperten. 19: 131-140, 1997.

21. Jacinto,S. M., Chintala, M. S., Lokhandwala, M. F. and Jandhyala, B. S.: Efficacy and

mechanisms of dopexamine in the prevention of ischemia-reperfusion induced organ damage: role of oxygen free radicals. Clin. Exp. Hyperten. 19: 181-190, 1997.

22. Hussain,T. and Lokhandwala, M. F.: Renal dopamine receptor function in

hypertension. Hypertension, 32: 187-197, 1998. 23. Hussain, T., Kansra, V. and Lokhandwala, M.F.: Renal dopamine receptor signaling

mechanisms in spontaneously hypertensive and Fisher 344 old rats. Clin. Exp. Hyperten. 21: 25-36, 1999.

24. Hussain, T. and Lokhandwala, M.F.: Renal dopamine receptors and hypertension.

Exp.Biol.Med. 228: 134-142, 2003. 25. Banday, A. A. and Lokhandwala, M. F.: Dopamine receptors and hypertension. Curr.

Hypertension Reports 10: 268-275, 2008.

26. Tayebati, S. K., Lokhandwala, M.F. and Amenta, F: Dopamine and vascular dynamics control: Present Status and futurte perspectives. Current Neurovascular Research, in press, 2011.

27. Asghar, M., Tayebati, S.K., Lokhandwala, M.F and Hussain, T.: Potential

Dopamine-1 Receptor Stimulation in Hypertension Management. Curr. Hypertension Reports, in press, 2011.

Research Papers 1. Lokhandwala, M.F., Patel, D.B., Patel, H., Merker, P.C., Shafiee, A. and Hite, G.:

Stereochemical investigations of local anesthetic action, J. Pharm. Sci. 60: 685-689, 1971.

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2. Lokhandwala, M.F., Cavero, I., Buckley, J.P. and Jandhyala, B,S.: Influence of pentobarbital anesthesia on the effects of certain autonomic blocking agents on heart rate, Europ. J. Pharmacol. 24: 274-277, 1973.

3. Cavero, I., Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: The effect of (-)-

delta 9-trans-tetrahydrocannabinol on myocardial contractility and venous return in anesthetized dogs, Europ. J. Pharmacol. 29: 74-82, 1974.

4. Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: Effect of methyldopa

treatment on peripheral sympathetic nerve function in the dog, Europ. J. Pharmacol. 32: 170-178, 1975.

5. Lokhandwala, M.F., Buckley, J.P. and Jandhyala,: B.S.: Effect of methyldopa

treatment on cardiac function and myocardial blood flow in mongrel dogs, Proc. Soc. Exp. Biol. Med. 151: 466-470, 1976.

6. Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: Studies on the mechanism of

cardiovascular effects of methyldopa, Europ. J. Pharmacol. 37: 79-89, 1976. 7. Lokhandwala, M.F., Asaad, M.M. and Buckley, J.P.: Effect of propranolol on vascular

responses to sympathetic nerve stimulation and plasma renin activity in mongrel dogs, Europ. J. Pharmacol., 38: 141-147, 1976.

8. Lokhandwala, M.F. and Buckley, J.P.: Effect of presynaptic alpha-adrenoceptor

blockade on responses to cardiac nerve stimulation in anesthetized dogs, Europ. J. Pharmacol. 40: 183-186, 1976.

9. Lokhandwala, M.F. and Buckley, J.P.: Analysis of presynaptic inhibitory actions of

various dopamine analogs on sympathetic neurotransmission in mongrel dogs, Life Sci. 20: 507-516, 1977.

10. Lokhandwala, M.F., Coates, J.T. and Buckley, J.P.: Effects of several catecholamines

on sympathetic transmission to the myocardium: Role of presynaptic alpha-adrenoceptors, Europ. J. Pharmacol. 42: 257-265, 1977.

11. Lokhandwala, M.F., Pariani, H.K., Buckley, J.P. and Jandhyala, B.S.: Involvement of

central alpha-adrenoceptors in the hypotensive and bradycardiac effects of (-)-∆9-transtetra- hydrocannabinol, Europ. J.Pharmacol. 42: 107-112, 1977.

12. Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: Effect of methyldopa

treatment on vagal cardioaccelerator system, Ind. J. Pharmacol. 9: 247-251, 1977. 13. Lokhandwala, M.F. and Buckley, J.P.: Presynaptic dopamine receptors as mediators

on dopamine-induced inhibition of neurogenic vasoconstriction, Europ. J. Pharmacol. 45: 305-309, 1977.

14. Lokhandwala, M.F. and Buckley, J.P.: The effect of L-dopa on peripheral sympathetic

nerve function: Role of presynaptic dopamine receptors. J. Pharmacol. Exp. Therap. 204: 362-371, 1978.

15. Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: Reduction of plasma renin

activity by centrally-administered angiotensin II in anesthetized cats, Clin. Exp. Hypertension, 1: 167-175, 1978.

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16. Lokhandwala, M.F.: Inhibition of sympathetic nervous system by histamine: Studieswith H1-and H2-receptor antagonists, J. Pharmacol. Exp. Therap. 206: 115-122, 1978.

17. Lokhandwala, M.F.: Pharmacological analysis of the tachycardia produced by

histamine and specific H1- and H2-receptor agonists in anesthetized dogs. Europ. J. Pharmacol. 51: 351-359, 1978.

18. Jandhyala, B.S., Washington, G.F. and Lokhandwala, M.F.: Influence of inhibition of

angiotensin converting enzyme with SQ-14225 on the arterial blood pressure of mongrel dogs. Res. Comm. Chem. Pathol. Pharmacol. 22: 257-265, 1978.

19. Lokhandwala, M.F., Amelang, E. and Buckley, J.P: Facilitation of cardiac

sympathetic function by angiotensin II: Role of presynaptic angiotensin receptors, Europ. J. Pharmacol. 52: 405-409, 1978.

20. Lokhandwala, M.F. and Jandhyala, B.S.: The role of sympathetic nervous system in

the vascular actions of dopamine, J. Pharmacol. Exp. Therap. 210: 120-126, 1979. 21. Jandhyala, B.S., Lokhandwala, M.F., Nandiwada, P. and Buckley, J.P.: Circulatory

effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs: Studies on the development of an experimental model of hypertension, Hypertension, 1: 219-277, 1979.

22. Lokhandwala, M.F.: Analysis of the effects of bromocriptine on blood pressure and

sympathetic nerve function, Europ. J. Pharmacol. 56: 253- 256, 1979. 23. Hardey, D.W. and Lokhandwala, M.F.: Influence of prazosin on cardiac reflex

function, Europ. J. Pharmacol. 57: 25l-254, 1979. 24. Lokhandwala, M.F.: Evidence for a neurogenic mechanism in dopmine induced

depressor response in the anesthetized dog, Ind. J. Pharmacol. 11: 101-105, 1979. 25. Jandhyala, B.S., Nandiwada, P., Buckley, J.P. and Lokhandwala, M.F.: Studies on the

mechanism of the hypotensive action of SQ-14225, an angiotensin converting enzyme inhibitor in anesthetized dogs. Res. Comm. Chem. Pathol. Pharmacol. 25: 429-446, 1979.

26. Jandhyala, B.S., Lokhandwala, M.F. and Buckley, J.P.: Circulatory effects of chronic

administration of angiotensin-II into the lateral cerebroventricles of dogs, Proc. West. Pharmacol. Soc. 22: 231-233, 1979.

27. Lokhandwala, M.F. and Jandhyala, B.S.: Sympathetic nerve function and renal

hemodynamics during hemorrhage: Role of pre- and post-synaptic interactions between angiotensin II and prostaglandins. J. Pharmacol. Exp. Therap. 211: 539-545, 1979.

28. Lokhandwala, M.F., Tadepalli, A.S. and Jandhyala, B.S.: Cardiovascular actions of

bromocriptine: Evidence for a neurogenic mechanism. J. Pharmacol. Exp. Therap. 211: 620-625, 1979.

29. Lokhandwala, M.F.: Inhibition of cardiac sympathetic neurotransmission by

adenosine, Europ. J. Pharmacol. 60: 353-357, 1979.

34

30. Hamed, A.T., Lokhandwala, M.F. and Jandhyala, B.S.: Relationship between plasma renin activity and hypotensive effect of captopril in dogs. Res. Comm. Chem. Pathol. Pharmacol. 28: 195-204, 1980.

31. Nandiwada, P.A., Lokhandwala, M.F. and Jandhyala, B.S.: Modulation by histamine

of peripheral vagal transmission in anesthetized mongrel dogs. Europ. J. Pharmacol. 63: 281-286, 1980.

32. Martinez, A.A. and Lokhandwala, M.F.: Evidence for a presynaptic inhibitory action

of 5-hydroxytryptamine on sympathetic neurotransmission to the myocardium. Europ. J. Pharmacol. 63: 303-311, 1980.

33. Ekas, R.D. and Lokhandwala, M.F.: Sympathetic nerve function and vascular

reactivity in DOCA-salt hypertensive rats. Amer. J. Physiol. 239: R303-R308, 1980. 34. Hom, G.J. and Lokhandwala, M.F.: Effect of dipyridamole on sympathetic nerve

function: Role of adenosine and presynaptic purinergic receptors. J. Cardiovasc. Pharmacol. 3:391-401, 1981.

35. Hamed, A.T. and Lokhandwala, M.F.: Control of hindlimb vascular resistance and

vascular responsiveness in DOCA-salt hypertensive dogs. Clin. Exp. Hypertension. 3: 85-101, 1981.

36. Hom, G.J. and Lokhandwala, M.F.: Presynaptic inhibition of vascular sympathetic

neurotransmission by adenosine. Europ. J. Pharmacol. 69: 101-106, 1981. 37. Barrett, R.J. and Lokhandwala, M.F.: Presynaptic dopamine receptor stimulation in

the cardiovascular actions of lergotrile. J. Pharmacol. Exp. Therap. 217: 660-665, 1981.

38. Hamed, A.T., Lokhandwala, M.F. and Jandhyala, B.S.: Effect of bromocriptine on

cardiac function and coronary blood flow. J. Cardiovasc. Pharmacol. 3: 636-646, 1981. 39. Jandhyala, B.S., Boe, A.M., Adamski, S.W. and Lokhandwala, M.F.: Studies on the

effects of histamine on cholinergic transmission to the heart and vasculature in the anesthetized cats. Arch. Int. Pharmacodyn. Therap. 249: 221-228, 1981.

40. Hamed, A.T., Lokhandwala, M.F. and Jandhyala, B.S.: Comparative evaluation of the

factors regulating vascular resistance in dogs, anesthetized with morphine-chloralose or pentobarbital. Arch. Int. Pharmacodyn.Therap. 249: 264-274, 1981.

41. Buckley, J.P., Lokhandwala, M.F., Steenberg, M.L., Francis, J.S. and Tadepalli, A.S.:

Cardiovascular effects of chronic intraventricular administration of angiotensin II in dogs. Clin. Exp. Hypertension, 3: 1001-1018, 1981.

42. Eikenburg, D.C., Ekas, R.D. and Lokhandwala, M.F.: Strain differences in the

facilitatory action of angiotensin on noradrenergic transmission in the rat mesentery. Clin. Exp. Hypertension, 3: 1039-1051, 1981.

43. Hamed, A.T., Jandhyala, B.S., Ginos, J.Z. and Lokhandwala, M.F.: Presynaptic

dopamine receptors and alpha-adrenoceptors as mediators of the bradycardic action of N-n-propyl-N-n-butyldopamine. Europ. J. Pharmacol. 74: 83-90, 1981.

35

44. Ekas, R.D. and Lokhandwala, M.F.: Sympathetic nerve function and vascular reactivity in spontaneously hypertensive rats. Amer. J. Physiol. 241: R379-R384, 1981.

45. Ekas, R.D., Steenberg, M.L., Eikenburg, D.C. and Lokhandwala, M.F.: Presynaptic

inhibition of sympathetic neurotransmission by adenosine in the rat kidney. Europ. J. Pharmacol. 76: 301-307, 1981.

46. Barrett, R.J. and Lokhandwala, M.F.: Circulatory and vestibular implications of

central angiotensin mechanisms in physiological adaptation to weightlessness. Medical Hypothesis, 7:1415-1419, 1981.

47. Barrett, R.J., Ginos, J.Z. and Lokhandwala, M.F.: Evaluation of peripheral dopamine

receptor and alpha-adrenoceptor blocking activity of sulpiride. Europ. J. Pharmacol. 79: 273-281, 1982.

48. Augustine, S.J., Buckley, J.P., Tachikawa, S. and Lokhandwala, M.F.: Involvement

of central noradrenergic mechanisms in the rebound hypertension following clonidine withdrawal. J. Cardiovasc. Pharmacol. 4: 449-455, 1982.

49. Barrett, R.J. and Lokhandwala, M.F.: Dopaminergic inhibition of cardiac sympathetic

nerve function by pergolide. Europ. J. Pharmacol. 77: 79-83, 1982. 50. Hamed, A. T. and Lokhandwala, M. F.: Impairment of neurally-mediated

vasoconscriction in DOCA-salt hypertensive dogs. Clin. Exp. Hypertension, A4: 867-881, 1982.

51. Barrett, R.J. and Lokhandwala, M.F.: Presynaptic dopamine receptor stimulation and

the antihypertensive action of pergolide in experimental neurogenic hypertension, Proc. West. Pharmacol. Soc. 25: 39-42, 1982.

52. Eikenburg, D.C., Ekas, R.D. and Lokhandwala, M.F.: Alterations in prejunctional

responsiveness to angiotensin II during the development of 2-kidney, 1-clip Goldblatt hypertension in rats. J. Pharmacol. Exp. Therap. 223: 766-773, 1982.

53. Ekas, R.D., Steenberg, M.L. and Lokhandwala, M.F.: Increased presynaptic alpha-

adrenoceptor mediated regulation of nopradrenaline release in spontaneously hypertensive rats. Clin. Sci. 63: 309s-311s, 1982.

54. Ekas, R.D., Steenberg, M.L. and Lokhandwala, M.F.: Increased norepinephrine

release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats. Clin. Exp. Hypertension, A5, 41-48, 1983.

55. Augustine, S.J., Tachikawa, S., Lokhandwala, M.F. and Buckley, J.P.: Central alpha-

adrenergic control of blood pressure: Rebount hypertension following clonidine withdrawal. Chest, 83S: 328S-331S, 1983.

56. Hamed, A.T., Ginos, J.Z., Ekas, R.D., Jandhyala, B.S. and Lokhandwala, M.F.: Renal

hemodynamics in hemorrhagic hypotension: studies on the effects of pre- and postjunctional dopamine receptor agonists. J. Cardiovasc. Pharmacol. 5: 207-212, 1983.

36

57. Ekas, R.D., Jr., Steenberg, M.L., Woods, M.S. and Lokhandwala, M.F.: Presynaptic alpha and beta-adrenoceptor stimulation and norepinephrine release in the spontaneously hypertensive rat. Hypertension, 5, 198-204, 1983.

58. Nath, R.G., Lokhandwala, M.F. and McCalden, T.A.: Evidence for presynaptic

dopaminergic inhibition of noradrenergic transmission in the rat portal vein. Proc. West. Pharmacol. Soc. 26: 377-379, 1983.

59. Peter, E.J., Eikenburg, D.C. and Lokhandwala, M.F.: Influence of the autonomic

nervous system in the hypotensive action of calcium antagonists in rats. Proc. West. Pharmacol. Soc. 26: 329-331, 1983.

60. Steenberg, M.L., Ekas, R.D., Jr. and Lokhandwala, M.F.: Effect of epinephrine on

norepinephrine release from rat kidney during symapthetic nerve stimulation. Europ. J. Pharmacol. 93: 137-148, 1983.

61. Dobbins, D.E., Adamski, S.W., Lokhandwala, M.F. and Grega, G.J.: Evidence that

serotonin receptors, but not alpha-adrenergic receptors as presynaptic mechanisms, contribute to the cutaneous vasoconstriction produced by 5-hydroxytryptamine in canine forelimbs. Circ. Res. 53: 473-481, 1983.

62. Eikenburg, D. C. and Lokhandwala, M. F.: Effects of Captopril on vascular

noradrenergic transmission during the development of 2-kidney, 1-clip Goldblatt hypertension in rats, J. Hypertension, 1: 115-122, 1983.

63. Barrett, R.J. and Lokhandwala, M.F.: Central and peripheral dopamnergic

mechanisms in the cardiovascular action of pergolide in neurogenic hypertensive dogs. Europ. J. Pharmacol. 96: 211-226, 1983.

64. Jadhav, A.L., Willett, R.N., Sapru, H.N. and Lokhandwala, M.F.: Involvement of

central dopamine receptors in the hypotensive action of pergolide. Naunyn-Schmiedeberg's Arch. Pharmacol. 324: 28l-286, 1983.

65. Sabouni, M. and Lokhandwala, M.F.: No evidence for the involvement of histamine

(H1 or H2) receptors in the hypotension and presynaptic inhibition of sympathetic inhibition of sympathetic nerve function caused by LY-141865 in dogs. Europ. J. Pharmacol. 97: 145-149, 1984.

66. Lokhandwala, M.F. and Steenberg, M.L.: Selective activation by LY-41865 and

apomorphine of presynaptic dopamine receptors in the rat kidney and influence of stimulation parameters in the action of dopamine. J. Pharmacol. Exp. Therap. 228: 161-167, 1984.

67. Lokhandwala, M.F., Kivlighn, S.D. and Jandhyala, B.S.: Characterization of

neurogenic vasodilatation elicited by central dopamine receptor stimulation with pergolide. J. Pharmacol. Exp. Therap. 228: 696-703, 1984.

68. Grega, G.J., Barrett, R.J., Adamski, S.W. and Lokhandwala, M.F.: Effects of

dopamine and SKF 82526, a selective DA1-receptor agonist, on vascular resistances in the canine forelimb. J. Pharmacol. Exp. Therap. 229: 696-703, 1984.

69. Lokhandwala, M.F. and Steenberg, M.L.: Evaluation of the effects of SKF 82526 and

LY 171555 on presynaptic (DA2) and postsynaptic (DA1) dopamine receptors in rat kidney. J. Auton. Pharmacol.4: 273-277, 1984.

37

70. Lokhandwala, M.F., Sabouni, M. and Jandhyala, B.S.: Cardiovascular actions of an

experimental antitumor agent, homoharringtonine, in anesthetized dogs. Drug Develop. Res. 5: 147-163, 1985.

71. Adamski, S.W., Dobbins, D.E., Lokhandwala, M.F. and Grega, G.J.: Effects of

dopamine and vasopressin on histamine-induced increases in macromolecular permeability in the canine forelimb. Microcirc. Endo. and Lymph, 2: 27-39, 1985.

72. Peter, E.J., Steenberg, M.L., Lokhandwala, M.F., Jandhyala, B.S. and Eikenburg,

D.C.: Influence of felodipine and verapamil on the sympathetic transmitter release and on the pre and postjunctional effects of exogenous norepinephrine in the perfused rat kidney. Drugs, 29 (Suppl.2) 198-204, 1985.

73. Lokhandwala, M.F., Watkins, H.O., Sabouni, M.H. and Alkadhi, K.A.:

Pharmacological analysis of the actions of SKF 82526 on cardiovascular dopamine receptors. J. Pharmacol. Exp. Therap. 234: 337-344, 1985.

74. Lokhandwala, M.F. and Sabouni, M.H.: Ganglionic dopamine receptors as mediators

of the inhibition of neurogenic vasoconstriction produced by fenoldopam. J. Auton. Pharmacol. 5: 301-306, 1985.

75. Sengupta, S. and Lokhandwala, M.F.: Characterization of the hypotensive actions of

dopamine receptor agonists fenoldopam and quinpirole in anesthetized rats. J. Auton. Pharmacol. 5: 286-295, 1985.

76. Sabouni, M. H., Alkadhi, K. A. and Lokhandwala, M. F.: Pharmacological

characterization of dopamine receptors in the stellate ganglia with selective DA1 and DA2 receptor agonists and antagonists. J. Pharmacol. Exp. Therap. 236: 65-70, 1986.

77. Alkadhi, K. A., Sabouni, M. H., Ansari, A. F. and Lokhandwala, M. F.: Activation of

DA1 receptors by dopamine or fenoldopam increases cyclic-AMP levels in the renal artery but not in the superior cervical ganglion of the rat. J. Pharmacol. Exp. Therap., 238: 547-553, 1986.

78. Hamed, A. T., Jandhyala, B. S. and Lokhandwala, M. F.: Evaluation of the role of

alpha-1 and alpha-2 adrenoceptors in the maintenance of neurogenic tone to the hindlimb vasculature, J. Pharmacol. Exp. Therap., 238: 599-605, 1986.

79. Sabouni, M. H., Alkadhi, K. A. and Lokhandwala, M. F.: Effect of dopamine receptor

activation on ganglionic transmission and cyclic-AMP levels in the stellate ganglia and renal arteries of the dog. J. Pharmacol. Exp. Therap. 240: 93-98, 1987 .

80. Sabouni, M. H., Alkadhi, K. A. and Lokhandwala, M. F.: Biochemical and

pharmacological characterization of ganglionic dopamine receptors, Clin. Exp. Hyperten., A9: 873-887, 1987.

81. Sowinski, B. A. and Lokhandwala, M. F.: Identification of dopamine receptor

subtypes in the hypotensive action of SK&F 85174 in anesthetized rats, J. Auton. Pharmacol., 7: 105-109, 1987.

82. Jandhyala, B. S., Lokhandwala, M. F., Kivlighn, S. D., Ansari, A. F., and DeFeo, M.

L.: Intracisternal administration of pergolide, a dopamine receptor agonist, triggers the

38

release of an inhibitor of ouabain-sensitive, sodium potassium-ATPase and enhances vascular reactivity in anesthetized dogs, Clin. Sci.. 73: 183-188, 1987.

83. DeFeo, M. L., Jadhav, A. L. and Lokhandwala, M. F.: Dietary sodium intake and

urinary dopamine and sodium excretion during the course of blood pressure development in Dahl salt-sensitive and salt-resistant rats. Clin. Exp. Hyperten., A9: 2049-2060, 1987.

84. Lokhandwala, M. F., Watkins, H. O. and Dlewati, A.: Different dopamine receptor

subtypes mediate neurogenic vasodilation producd by fenoldopam and SK&F 85174 in the dog hindlimb. Europ. J. Pharmacol., 143: 383-390, 1987.

85. Hegde, S. S. and Lokhandwala, M. F.: Involvement of cyclic-AMP in the hypotensive

response to fenoldopam but not to quinpirole in the anaesthetized rat. J. Auton. Pharmacol., 8: 63-88, 1988.

86. Steenberg, M. L., Lokhandwala, M. F. and Jandhyala, B. S.: Abnormalities in the

sodium transport as the causative factor for enhanced norepinephrine overflow in the spontaneously hypertensive rat. Clin. Exp. Hyperten., A10: 833-841, 1988.

87. Dlewati, A., Chelly, J. E., Doursout, M.-F. and Lokhandwala, M. F.: Renal, cardiac

and systemic hemodynamic effects of the dopamine receptor agonist SK&F 85174 in anesthetized dogs. Drug Dev. Res., 16: 71-77, 1989.

88. Dlewati, A., Watkins, H. O. and Lokhandwala, M. F.: Effects of SK&F 85174, a DA-1/DA-2 receptor agonist, on pre- and postganglionic sympathetic

neurotransmission to the heart. Europ. J. Pharmacol., 164: 197-203, 1989. 89. Hegde, S. S. and Lokhandwala, M. F.: Role of kidney dopamine in the natriuretic

response to volume expansion in rats. Hypertension, 13: 828-834, 1989. 90. Hegde, S. S., Ricci, A., Amenta, F. and Lokhandwala, M. F.: Evidence from

functional and autoradiographic studies for the presence of tubular dopamine-1 receptors and their involvement in the renal effects of fenoldopam. J. Pharmacol. Exp. Therap., 251: 1237-1245, 1989.

91. Jadhav, A. L. and Lokhandwala, M. F.: Dietary sodium-induced changes in renal

noradrenergic and dopaminergic responses in rats. J. Human Hyperten., 4: 163-164, 1990.

92. Grega, G. J., Staniciu, D., Murray, M. and Lokhandwala, M. F.: Effects of

dopexamine hydrochloride, a beta-adrenergic and dopaminergic agonist, on vascular resistances, and flow distribution between cutaneous and skeletal muscle vasculatures. Drug Dev. Res. 22: 69-77, 1991.

93. Dlewati, A. and Lokhandwala, M. F.: Dose-response analysis of the effects of

fenoldopam, a dopamine-1 receptor agonist, on renal function. Drug Dev. Res. 22: 59-68, 1991.

94. Vyas, S. J., Apparsundaram, S., Ricci, A., Amenta, F. and Lokhandwala, M. F.:

Biochemical, autoradiographic and pharmacological evidence for the involvement of tubular DA-1 receptors in the natriuretic response to dopexamine hydrochloride. Naunyn- Schmiedeberg's Arch. Pharmacol., 343: 21-30, 1991.

39

95. Amenta, F., Ricci, A., Napoleone, P., Vyas, S. J. and Lokhandwala, M. F.: Anatomical localization of the binding and functional characterization of responses to dopexamine hydrochloride in the rat mesenteric vasculature. Pharmacology, 42: 211-222, 1991.

96. Chen, C.-J., Apparsundaram, S. and Lokhandwala, M. F.: Intrarenally produced

angiotensin II opposes the natriuretic action of the DA-1 receptor agonist fenoldopam in rats. J. Pharmacol. Exp. Ther., 256: 486-491, 1991.

97. Hegde, S. S., Chen, C. J. and Lokhandwala, M. F.: Involvement of endogenous

dopamine and DA-1 receptors in the renal effects of atrial natriuretic factor in rats. Clin. Exp. Hyperten., A13: 357-369, 1991.

98. Chen, C. J. and Lokhandwala, M. F.: Role of endogenous dopamine in the natriuretic

response to various degrees of iso-osmotic volume expansion in rats. Clin. Exp. Hyperten., A13:1117-1126, 1991.

99. Jadhav, A. L., Ricci, A., Amenta, F. and Lokhandwala, M. F.: Renal dopamine and

changes in dopamine receptor ligand binding during high sodium intake. Clin. Exp. Hyperten., A13:1371-1381, 1991.

100. Vyas, S. J., Eichberg, J. and Lokhandwala, M. F.: Characterization of receptors

involved in dopamine induced activation of phospholipase-C in rat renal cortex. J.Pharmacol. Exp. Ther., 260:134-139, 1992.

101. Chen, C. J., Vyas, S. J., Eichberg, J. and Lokhandwala, M. F.: Diminished

phospholipase-C activation by dopamine in the kidney of spontaneously hypertensive rats. Hypertension, 19:102-108, 1992.

102. Vyas, S. J., Jadhav, A. L., Eichberg, J. and Lokhandwala, M. F.: Dopamine receptor

mediated activation of phospholipase-C is associated with natriuresis during high sodium intake. Amer. J. Physiol: Renal Physiol. 262: F494-F498, 1992.

103. Sakamoto, T. and Lokhandwala, M. F.: Effect of fenoldopam prodrug SK&F R-

105058 on renal function in rats. Drug Dev. Res., 26:79-88, 1992. 104. Chen, C. J. and Lokhandwala, M. F.: An impairment of renal tubular DA-1 receptor

function as the causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats. Clin. Exp. Hyperten., A14: 615-628, 1992.

105. Hegde, S. S. and Lokhandwala, M. F.: Stimulation of renal dopamine production

during acute volume expansion requires the presence of intact vagi but not renal nerves. Clin. Exp. Hyperten., A14: 1169-1187, 1992.

106. Chen, C. J., Beach, R. E. and Lokhandwala, M. F.: Dopamine fails to inhibit sodium

pump in hypertensive rats. Hypertension, 21: 364-372, 1993. 107. Chen, C. J. and Lokhandwala, M. F.: Inhibition of Na+, K+ -ATPase in rat renal

proximal tubule by dopamine involves DA-1 receptor activation. Naunyn-Schmiedberg’s Arch. Pharmacol. 347: 289-295, 1993.

108. Chintala, M.S., Moore, R.J., Lokhandwala, M.F. and Jandhyala, B.S.: Evaluation of

the effects of dopexamine, a novel DA-1 receptor and beta-2 adrenoceptor agonist on

40

cardiac function and splanchnic circulation in a canine model of haemorrhagic shock. Naunyn-Scmiedeberg’s Arch. Pharmacol. 347: 296-300, 1993.

109. Gopalakrishnan, S., Chen, C .J. and Lokhandwala, M .F.: Identification of α1-adrenoceptor subtypes in the rat renal proximal tubules, Europ. J. Pharmacol, 250:

469-472, 1993. 110. Sakamoto, T., Chen, C .J. and Lokhandwala, M .F.: Lack of renal dopamine

production during acute volume expansion in Dahl salt-sensitive rats. Clin. Exp. Hyperten., 16:197-206, 1994.

111. Sakamoto, T., Chen, C. J. and Lokhandwala, M. F.: Attenuation of adenylate cyclase

induced increases in renal sodium excretion by Dopamine (DA)-2 receptor agonist SK&F 89124. J. Auton. Pharmacol. 14: 295-306, 1994.

112. Sakamoto, T., Chen, C. J. and Lokhandwala, M. F.: Contribution by bradykinin to the

natriuretic response to angiotensin cnverting enzyme inhibitor, ramiprilat in spontaneously hypertensive rats. Naunyn-Schiemedeberg’s Arch. Pharmacol. 350: 84-89, 1994.

113. Jacinto, S.M., Lokhandwala, M.F. and Jandhyala, B.S.:Studies on the phamacological

interventions to prevent oxygen free radical mediated toxicity; Effects of dopexamine, a DA1 receptor and β2 adrenoceptor agonist. Naunyn-Schmiedeberg’s Arch. Pharmacol. 350: 277-283, 1994.

114. Gopalakrishnan, S. M., Chen, C. J. and Lokhandwala, M. F.: α1-Adrenoceptor

subtypes mediating stimulation of sodium, potassium-ATPase activity, and activation of inositol trisphosphate and protein kinase C in rat renal proximal tubules.Europ. J. Pharmacol. Mol. Pharmacol Sec. 288: 139-147, 1995.

115. Kansra, V., Chen,C.J. and Lokhandwala, M.F.: Dopamine causes stimulation of

protein kinase C in rat renal proximal tubules by activating dopamine D1 receptors. Europ. J. Pharmacol. Mol. Pharmacol. Sec.289: 391-394, 1995.

116. Chen C. J. and Lokhandwala, M. F.: Potentiation by enalaprilat of fenoldopam-evoked

natriuresis is due to blockade of intrarenal production of angiotensin II in rats. Naunyn-Schmiedeberg’s Arch. Pharmacol. , 352: 194-200, 1995.

117. Kansra,V., Chen,C.J. and Lokhandwala, M.F.: Dopamine fails to stimulate protein

kinase C activity in renal proximal tubules of spontaneously hypertensive rats. Clin.Exp. Hypertension, 17: 837-845, 1995.

118. Chen, C. J. and Lokhandwala, M. F.: Identification of α1-adrenoceptor subtypes

involved in the antinatriuretic response to intrarenal infusion of phenylephrine. Europ.J. Pharmacol. 287: 1-6, 1995.

119. Jacinto, S.M., Lokhandwala, M.F. and Jandhyala, B.S.: Effect of pharmacological

interventions in the prevention of lipid peroxidation and respiratory depression induced by oxygen free radicals in anesthetized rats. Free Radical Biol. and Med. 21: 791-799, 1996.

120. Hussain,T. and Lokhandwala, M. F.: Altered arachadonic acid metabolism contributes

to the failure of dopamine to inhibit Na,K-ATPase in kidney of spontaneously hypertensive rats. Clin Exp Hypertension, 18: 963-974, 1996.

41

121. Hussain, T. and Lokhandwala, M. F. : Renal dopamine-1 receptor coupling with Gs

and Gq/11proteins in spontaneously hypertensive rats. Amer. J. Physiol: Renal Physiol.272: F339-F346, 1997.

122. Pedemonte, C.H., Pressley, T. A., Lokhandwala, M. F. and Cinelli, A. R.: Regulation

of Na,K-ATPase transport activity by protein kinase C. J. Membrane Biol.. 155: 219-227, 1997.

123. Hussain, T., Abdul-Wahab, R. and Lokhandwala, M. F.: Bromocriptine stimulates

Na+,K+-ATPase in renal proximal tubules via cAMP pathway. Europ. J. Pharmacol. 231: 259-263, 1997.

124. Kansra, V., Hussain, T. and Lokhandwala, M. F.: Alterations in DA1 receptor and G-

proteins in renal proximal tubules of old rats. Amer. J. Physiol: Renal Physiol. 273: F53-F59, 1997.

125. Pedemonte, C.H., Pressley, T.A., Cinelli, A.R. and Lokhandwala, M.F.: Stimulation

of protein kinase C rapidly reduces intracellular Na+ concentration via activation of Na+ -pump in OK cells. Mol. Pharmacol. 52: 88-97, 1997.

126. Bharatula, M., Hussain, A. and Lokhandwala, M. F.: Angiotensin II AT1

receptor/signaling mechanisms in the biphasic effect of the peptide on proximal tubular Na+, K+ -ATPase. Clin. Exp. Hypertension, 20:465-480, 1998.

127. Hussain, T., Abdul-Wahab, R., Kotak, D. and Lokhandwala, M.F.: Bromocriptine

regulates angiotensin II response on sodium pump in proximal tubules. Hypertension, 32: 1054-1059, 1998.

128. Vieira~Coelho, M.A., Hussain,T., Kansra, V., Serraro, P., Guimares, J.T., Pestana, M.,

Soares-da-Silva, P. and Lokhandwala, M.F.: Aging, high salt intake and renal dopaminergic activity in Fischer 344 rats. Hypertension, 34: 666-672, 1999.

129. Hussain, T., Beheray, S. and Lokhandwala, M.F.: Defective dopamine receptor

function in renal proximal tubules of obese Zucker rats. Hypertension, 34: 1091-1096, 1999.

130. Lokhandwala, M.F. and Hussain, T.: Defective renal dopamine D1-like receptor

signal transduction in obese hypertensive rats. Acta. Physiol. Scand. 168: 251-255, 2000.

131. Beheray, S., Kansra, V., Hussain, T. and Lokhandwala, M. F.: Diminished natriuretic

response to dopamine in old rats is due to an impaired D1-like receptor signaling pathway. Kidney International, 58: 712-720, 2000.

132. Venkatakrishnan, U., Chen, C. and Lokhandwala, M. F.: The role of nitric oxide in the

natriuretic response to dopamine-1 receptor activation. Clin. Exp. Hypertension, 22: 309-324, 2000.

133. Beheray, S., Hussain, T. and Lokhandwala, M. F.: Dopamine inhibits Na,H-exchanger

via D1-like receptor-mediated stimulation of protein kinase A in renal proximal tubules. Clin Exp Hypertension, 22: 635-644, 2000.

42

134. Asghar, M., Kansra, V., Hussain, T. and Lokhandwala, M.F.: Hyperphos-phorylation of Na-pump contributes to defective renal dopamine response in old rats. J. Amer. Soc. Nephrol. 12: 226-232, 2001.

135. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Activation of dopamine D1-like receptor causes phosphorylation of alpha-1 subunit of Na,K ATPase in rat renal proximal tubules. Europ. J. Pharmacol. 411: 61-66, 2001.

136. Narkar, V.A., Hussain, T., Pedemonte, C. and Lokhandwala, M.F.: Dopamine D2-like receptor activation causes mitogenesis via p44/42 MAPK in opposum kidney cells. J. Amer. Soc. Nephrol , 12: 1844-1852, 2001.

137. Vieira-Coelho, M.A., Serrao, P., Hussain,T., Lokhandwala, M.F., and Soares-da-Silva, P.: Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats. Life Scinces, 69: 1957-1968, 2001.

138. Ricci, A., Amenta, F., Bronzetti, E., Felici, A., Hussain, T., and Lokhandwala, M.F.: Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree. Mech of Aging and Develop, 123: 537-546, 2002.

139. Hussain, T., Becker, M., Beheray, S. and Lokhandwala, M. F.: Dopamine fails to inhibit Na,H-exchanger in proximal tubules of obese zucker rats. Clin.Exp. Hypertension 23: 591-601, 2001.

140. Narkar,V., Hussain, T. and Lokhandwala, M. F.: Role of tyrosine kinase and p44/42

MAPK in D2-like receptor-mediated stimulation of Na,K-.ATPase in kidney. Amer. J. Physiol: Renal Physiol. 282: F697-F702, 2002.

141. Lucas-Teixeira , V.A., Hussain, T., Serrao, P., Soares-da-Silva, P. and Lokhandwala,

M.F.: Intestinal dopaminergic activity in obese and lean Zucker rats: Response to high salt intake. Clin. Exp. Hypertension, 24: 383-396, 2002.

142. Asghar, M., Hussain,T. and Lokhandwala, M.F.: Higher basal phosphorylation of

D1A receptors in the proximal tubules of old Fischer rats. Amer. J. Physiol: Renal Physiol. 283: F350-F355, 2002.

143. Narkar, V., Hussain, T. and Lokhandwala, M.F.: Activation of D2-like dopamine

receptors causes recruitment of tyrosine phosphorylated Na, K- ATPase alpha 1-subunits in the kidney. Amer. J. Physiol: Renal Physiol. 283: F1290-F1295, 2002.

144. Umrani, D. M., Banday, A. A., Hussain, T. and Lokhandwala, M. F.: Rosiglitazone

Treatment Restores Renal Dopamine Receptor Function in Obese Zucker Rats. Hypertension, 40: 880-885, 2002.

145. Becker, M., Umrani, D., Lokhandwala, M.F. and Hussain, T.: Increased renal

angiotensin II AT1 receptor function in obese Zucker rat. Clin. Exp. Hypertension, 25: 59-71, 2003.

146. Banday,A.A., Asghar, M., Hussain, T. and Lokhandwala, M.F.: Dopamine-mediated

inhibition of renal Na,K-ATPase is reduced by insulin. Hypertension, 41: 1353-1358, 2003.

43

147. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Over-expression of PKC-βI and –δ contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats. Amer. J. Physiol: Renal Physiol. 285: F1100-F1107, 2003.

148. Marwaha, A. and Lokhandwala, M.F: Diminished natriuretic response to dopamine

D1-receptor agonist, SKF-38393 in Obese Zucker rats. Clin. Exp. Hypertension, 25: 509-516, 2003.

149. Marwaha, A., Banday, A.A. and Lokhandwala, M.F.: Reduced renal dopamine D1

receptor function in streptozotocin-induced diabetic rats. Amer.J.Physiol: Renal Physiol. 286: F451-F457, 2004.

150. Trivedi, M., Marwaha, A. and Lokhandwala, M.F.: Rosiglitazone restores recruitment,

G-protein coupling and function of renal dopamine D1 receptors in obese Zucker rats. Hypertension, 43: (Part2): 376-382, 2004.

151. Asghar, M. and Lokhandwala, M.F.: Antioxidant supplementation normalizes

elevated protein kinase C activity in proximal tubules of old rats. Exp. Biol. Med 229: 27-275, 2004.

152. Narkar, V., Kunduzova, O., Hussain, T., Cambon, C., Parini, A. and Lokhandwala,

M.F.: Dopamine D2-like receptor agonist bromocriptine protects against ischemia-reperfusion injury in rat kidney. Kidney International, 66: 634-640, 2004.

153. Banday, A. A., Hussain, T. and Lokhandwala, M. F.: Renal dopamine D1 receptor

function is aquired and not inherited in obese Zucker rats. Amer. J. Pysiol: Renal Physiol. 287: F109-F116, 2004.

154. Trivedi, M., Narkar, V. A., Hussain, T. and Lokhandwala, M. F.: Dopamine recruits

D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules. Amer. J. Physiol: Renal Physiol. 287: F921-F931, 2004.

155. Trivedi, M. and Lokhandwala, M.F.: Rosiglitazone restores renal D1A receptor-Gs-

protein coupling by reducing receptor hyperphosphorylation in obese rats. Amer J. Physiol: Renal Physiol. 289: F298-F304, 2005.

156. Banday, A.A., Marwaha, A. and Lokhandwala, M.F.: Tempol reduces oxidative

stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation and restores D1 recptor-G protein coupling and function in obese Zucker rats. Diabetes, 54: 2219-2226, 2005.

157. Asghar, M. Banday, A. A., Fardoun, R. and Lokhandwala, M.F.: Hydrogen peroxide

causes uncoupling of dopamine D1 receptors from G-proteins via a mechanism involving PKC and GRK2. Free Radical Biol. & Med. 40: 13-20, 2006.

158. Marwaha, A. and Lokhandwala, M. F.: Tempol reduces oxidative stress and restores

renal dopamine D1-like receptor G-protein coupling and function in hyperglycemic rats. Amer J Physiol: Renal Physiol. 291: F58-F66, 2006.

159. Asghar, M. and Lokhandwala, M.F.: Antioxidant tempol decreases age-related

increase in insulin resistance in old Fischer 344 rats. Clin Exp Hypertension, 28: 533-541, 2006.

44

160. Fardoun, R. Z., Asghar, M. and Lokhandwala, M.F.: Role of Oxidative Stress in Defective Renal Dopamine D1 Receptor- G-Protein Coupling and Function in Old Fischer 344 Rats. Amer J Physiol: Renal Physiol. 291: F945-F951, 2006.

161. Banday, A.A. and Lokhandwala, M.F.: Defective renal dopamine D1 receptor

function contributes to hyperinsulinemia mediated hypertension. Clin Exp Hypertension, 28: 695-705, 2006.

162. Banday, A.A., Fazili, F.R., Marwaha, A.A. and Lokhandwala, M.F.: Mitogen-

activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Kidney International, 71: 397-406, 2007.

163. Fardoun, R. Z., Asghar, M. and Lokhandwala, M.F.: Role of NFkB in oxidative

stress-induced defective dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. Free Radical Biol. & Med. 42: 756-764, 2007.

164. Banday, A. A., Muhammad, A.B., Fazili, F.R. and Lokhandwala, M.F.: Mechanism of

oxidative stress induced increase in salt sensitivity and development of hypertension in Sprague Dawley rats, Hypertension, 49[part 2]: 664-667, 2007.

165. Banday, A. A., Fazili, F. R. and Lokhandwala, M. F.: Oxidative stress causes renal

dopamine D1 receptor dysfunction and hypertension via mechanisms involving nuclear factor-kB and protein kinase C. J Amer Soc Nephrol, 18: 1446-1457, 2007.

166. Asghar, M., Monjok, E., Kouamou, G., Ohia, S.E., Bagchi, D. and Lokhandwala,

M.F.: Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance and body weight in developing obese Zucker rats. Mol. Cell. Biochem. 304: 93-99, 2007.

167. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress reduces renal dopamine D1

receptor-Gq/11α G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2. Amer J Physiol: Renal, 293: F306-F315, 2007.

168. Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Insulin Causes Renal Dopamine

D1 Receptor Desensitization via GRK2-mediated Receptor Phosphorylation Involving Phosphatidylinositol3-Kinase and Protein kinase C. Amer J Physiol: Renal, 293: F877-F884, 2007.

169. Asghar, M., George, L. and Lokhandwala, M.F.: Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. Amer J Physiol: Renal Physiol. 293: F914-F919., 2007.

170. Banday, A.A., Lau, Y-S and Lokhandwala, M.F.: Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley Rats. Hypertension, 51: 367- 375, 2008.

171. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension. Amer J Physiol: Renal Physiol., 295: F698-F706, 2008.

172. Asghar, M., Chillar, A. and Lokhandwala, M.F.: Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in culture and exhibit inceresed oxidative

45

stress and reduced D1 receptor function. Amer J Physiol: Cell Physiol. 295: C1326-C1331, 2008.

173. Banday, A. A. and Lokhandwala, M.F.: Loss of biphasic effect on Na/K-ATPase activity by angiotensin II involves defective angiotensin typr 1 receptor-nitric oxide signaling. Hypertension, 52: 1099-1105, 2008.

174. Banday, A.A. and Lokhandwala, M.F.: Inhibition of natriuretic factors increases blood pressure in rats. Amer J Physiol: Renal Physiol., 297: F397-F402, 2009.

175. George, L., Lokhandwala, M.F. and Asghar, M: Exercise activates redox sensitive transcription factors and restores renal D1 receptor function in old rats. Amer J Physiol: Renal Physiol., 297: F1174-1180, 2009.

176. Asghar, M., Chugh, G. and Lokhandwala, M.F.: Inflammation compromises renal dopamine D1 receptor function in rats. Amer J Physiol: Renal Physiol., 297: F1543-F1549, 2009.

177. Muhammad, A.B., Lokhandwala, M.F. and Banday, A.A.: Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese Zucker rats. Amer J Physiol: Renal Physiol, 300:F98-F104, 2011.

178. Chugh, G., Lokhandwala, M.F. and Asghar, M.: Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats. Amer J Physiol: Renal Physiol, 300: F133-F138, 2011.

179. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation and hypertension. Hypertension, 57: 452-459, 2011.

180. Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Europ. J. Pharmacol., in press, 2011.

181. Banday, A.A. and Lokhandwala, M.F.: Angiotensin II-Mediated Biphasic Regulation of Proximal Tubular Na+/H+ Exchanger 3 is Impaired during Oxidative Stress. Amer J Physiol: Renal Physiol, in press, 2011.

Abstracts 1. Lokhandwala, M.F. and Jandhyala, B.S.: Effect of hexamethonium on cardiac rate in

conscious dogs. Fed. Proc. 32: 800, 1973. 2. Lokhandwala, M.F., Vollmer, R., Jandhyala, B.S. and Buckley, J.P.: The effect of

chronic administration of guanethidine on sympathetic neuronal function in dogs. Fed. Proc. 33:470, 1974.

46

3. Cavero, I., Lokhandwala, M.F., Jandhyala, B.S. and Gerold, M: Effects of (-)-∆9-transtetrahydrocannabinol (THC) on venous return in dogs. Experientia, 30: 694, 1974.

4. Lokhandwala, M.F.: Effects of methyldopa on regional hemodynamics and

sympathetic nerve function in the dog. Fed. Proc. 34: 817, 1975. 5. Lokhandwala, M.F., Buckley, J.P. and Jandhyala, B.S.: Further studies on the

mechanism of action of methyldopa mongrel dogs. Pharmacologist 17: 224, 1975. 6. Lokhandwala, M.F. and Buckley, J.P.: Studies on the role of various factors in the

antihypertensive action of propranolol. Fed. Proc. 35: 771, 1976. 7. Lokhandwala, M.F. and Buckley, J.P.: Presynaptic modulation of sympathetic

transmission to the myocardium by various catecholamines. Circulation, 54: II-1977. 8. Buckley, J.P. Singh, S., Jandhyala, B.S. and Lokhandwala, M.F.: Central effects of

angiotensin II on renal hemodynamics, plasma renin activity and water and electrolyte excretion. Fed. Proc. 36: l377, 1977.

9. Lokhandwala, M.F.: Studies on the mechanism of L-dopa induced impairment of

sympathetic nervous transmission in anesthetized dogs. Fed. Proc. 36: 3671, 1977. 10. Jandhyala, B.S., Pariani, H.K. and Lokhandwala, M.F.: The role of central alpha-

adrenergic receptors in the hypotension and bradycardia produced by ∆9-tetrahydrocannabinol in the anesthetized cat. Fed. Proc. 36: 3575, 1977.

11. Lokhandwala, M.F.: Effect of histamine on sympathetic nerve function in mongrel

dogs. Fed. Proc. 37: 2064, 1978. 12. Amelang, E., Buckley, J.P. and Lokhandwala, M.F.: Evidence for a facilitatory effect

of angiotensin II on sympathetic nerve function to the myocardium in mongrel dogs. Pharmacologist, 20: 310, 1978.

13. Hardey, D.W. and Lokhandwala, M.F.: Studies on the mechanism of cardiovascular

actions of prazosin in the anesthetized dog. Pharmacologist 20: 233, 1978. 14. Jandhyala, B.S., Nandiwada, P., Buckley, J.P. and Lokhandwala, M.F.: Relationship

between inhibition of angiotensin I converting enzyme (ACE) and hypotensive activity of SQ-14225 in dogs. Pharmacologist, 20: 582, 1978.

15. Buckley, J.P., Lokhandwala, M.F., Amelang, E., Nandiwada, P. and Jandhyala, B.S.:

Circulatory effects of chronic intraventricular administration of angiotensin II in dogs. Circulation, 57 and 58: Suppl-II- 143, 1978.

16. Martinez, A.A. and Lokhandwala, M.F.: Effect of 5-hydroxytryptamine on

sympathetic nerve function. Fed. Proc. 38: 1963, 1979. 17. Buckley, J.P., Saelens, D., Lokhandwala, M.F. and Jandhyala, B.S.: Cardiovascular

effects of chronic intraventricular administration of angiotensin II in dogs. Fed. Proc. 38: 2364, 1979.

18. Lokhandwala, M.F., Washington, G.F. and Jandhyala, B.S.: The role of presynaptic

dopamine receptors in the cardiovascular actions of bromocriptine. Pharmacologist, 21: 20, 1979.

47

19. Nandiwada, P., Lokhandwala, M.F. and Jandhyala, B.S.: Modification by histamine of

vagally mediated bradycardic effects in the anesthetized mongrel dog. Pharmacologist, 21: 632, 1979.

20. Lokhandwala, M.F. and Jandhyala, B.S.: The role of angiotensin II and

prostaglandins in control of renal hemodynamics during hemorrhage. Physiologist, 22: 78, 1979.

21. Nandiwada, P., Lokhandwala, M.F. and Jandhyala, B.S.: Evidence for the role of H2

receptor in the modulation of peripheral vagal transmission in pentobarbital anesthetized dog. Physiologist, 22: 93, 1979.

22. Ekas, R.D. and Lokhandwala, M.F.: Sympathetic nerve function and vascular

reactivity in DOCA-salt hypertension. Proc. SW Sec. Soc. Exp. Biol. Med., 1:30, 1979. 23. Lokhandwala, M.F.: Involvement of presynaptic dopamine receptors in the

cardiovascular actions of bromocriptine. Proc. SW Sec. Soc. Exp. Biol. Med. l: 47, 1979.

24. Augustine, S.J. and Lokhandwala, M.F.: Alterations in responses of pre- and

postsynaptic alpha-adrenoceptors during withdrawal of chronic clonidine treatment in rats, Fed. Proc. 39, 699, 1980.

25. Hamed, A.T. and Lokhandwala, M.F.: The effect of DOCA-salt hypertension on

hindlimb vascular resistance in dogs. Fed. Proc. 39: 1210, 1980. 26. Barrett, R.J. and Lokhandwala, M.F.: Involvement of a dopaminergic mechanism in

the cardiovascular actions of lergotrile in dos. Fed. Proc. 39: 1860, 1980. 27. Hom, G.J. and Lokhandwala, M.F.: The effect of adenosine on sympathetic nerve

function: Influence of dipyridamole and theophylline. Fed. Proc. 39: 3111, 1980. 28. Ekas, R.D. and Lokhandwala, M.F.: No evidence for alterations in norepinephrine

release in DOCA-salt hypertensive rats. Fed. Proc. 39: 4832, 1980. 29. Lokhandwala, M.F. and Ekas, R.D.: Evidence for an increase in norepinephrine

release in the spontaneously hypertensive rat. Pharmacologist, 22: 34, 1980. 30. Buckley, J. P., Lokhandwala, M.F., Francis, J.S., Tadepalli, A.S., Steenberg, M.L. and

Jandhyala, B.S.: Effectss of chronic intraventricular administration of angiotensin II in dogs. VIIth Scientific Meeting of the International Society of Hypertension. Abst.#15, 1980.

31. Ekas, R.D. and Lokhandwala, M.F.: Vascular hyperresponsiveness in the

spontaneously hypertensive rat: Evidence for an increase in norepinephrine release. VIIth Scientific Meeting of the International Society of Hypertension. Abst. #29, 1980.

32. Adamski, S., Francis, J.S., Buckley, J.P. and Lokhandwala, M.F.: Effects of

intraventricular administration of bepridil on cardiovascular hemodynamics of anesthetized and conscious dogs. Neuroscience, Abst. 6: 164, 1980.

48

33. Augustine, S.J. and Lokhandwala, M.F.: Characteristics and Mechanisms of clonidine withdrawal syndrome in normotensive and spontaneously hypertensive rats. Fed. Proc. 40: 32, 1981.

34. Ekas, R.D., Eikenburg, D.C., Steenberg, M.L. and Lokhandwala, M.F.: Presynaptic

regulation of endogenous norepinephrine release in the isolated perfused rat kidney. Fed. Proc. 40: 106, 1981.

35. Barrett, R.J. and Lokhandwala, M.F.: The role of alpha-adrenergic and dopamine

receptor activation in the cardiovascular effects of pergolide. Fed. Proc. 40: 315, 1981. 36. Lokhandwala, M.F. and Barrett, R.J.: Mechanism of potentiation of responses to

cardiac nerve stimulation by sulpiride. Fed. Proc. 40, 316, 1981. 37. Hamed, A.T., Jandhyala, B.S., Ginos, J.Z. and Lokhandwala, M.F.: Mechanism of

bradycardic action of N-n-propyl-N-n-butyl dopamine: Involvement of presynaptic dopamine and alpha adrenoceptors. Fed. Proc. 40, 453, 1981.

38. Eikenburg, D.C., Ekas, R.D. and Lokhandwala, M.F.: Presynaptic action of

angiotensin II and vascular reactivity during development of 2-kidney Gold-blatt hypertension. Fed. Proc. 40: 1729, 1981.

39. Augustine, S.J., Buckley, J.P., Tachikawa, S. and Lokhandwala, M.F.: Involvement

of central noradrenergic mechanisms in rebound hypertension precipitated by clonidine withdrawal. VIIIth Scientific Meeting of the International Society of Hypertension. Abst. #31, 1981.

40. Chelly, J., Lokhandwala, M.F., Huchet, A.M., Doursoud, M.F., Schmitt, H. and

Buckley, J.P.: L-glutamate induces neurogenic hypertension in dogs. VIIIth Scientific Meeting of the International Society of Hypertension. Abst. #77, 1981.

41. Barrett, R.J. and Lokhandwala, M.F.: Pharmacologic and therapeutic implications of

presynapticc dopamine receptor stimulation in experimental hypertension. IXth Scientific Meeting of the International Society of Hypertenison. Abst. #33, 1982.

42. Eikenburg, D.C. and Lokhandwala, M.F.: In vivo modulation of vascular sympathetic

neurotransmission by angiotensin II during the development of 2-kidney Goldblatt hypertension. IXth Scientific Meeting of the International Society of Hypertension. Abst. #104, 1982.

43. Ekas, R.D., Steenberg, M.L. and Lokhandwala, M.F.: Increased presynaptic alpha-

adrenoceptor-mediated regulation of norepinephrine release in the isolated perfused kidney of spontaneously hypertensive rats. IXth Scientific Meeting of the International Society of Hypertension. Abst. #105, 1982.

44. Steenberg, M.L. Ekas, R.D. and Lokhandwala, M.F.: Facilitation of norepinephrine

release by beta-adrenoceptor agonists during sympathetic nerve stimulation in the isolated perfused rat kidney. Fed. Proc. 41: 4592, 1982.

45. Hamed, A.T., Jandhyala, B.S. and Lokhandwala, M.F.: Effects of dopamine receptor

agonists on renal and femoral hemodynamics following acute hemorrhagic hypotension in anesthetized dogs. Fed. Proc. 41: 5834, 1982.

49

46. Lokhandwala, M.F., Steenberg, M.L. and Ekas, R.D.: Alterations in presynaptic alpha-adrenoceptor-mediated regulation of norepinephrine release in spontaneously hypertensive rats. Fed. Proc. 41: 6274, 1982.

47. Eikenburg, D.C. and Lokhandwala, M.F.: Lack of prejunctional adrenergic facilitation

by angiotensin II in 2-kidney Goldblatt hypertension. Fed. Proc. 41: 7694, 1982. 48. Barrett, R.J. and Lokhandwala, M.F.: Central dopaminergic mechanisms in the

cardiovascular actions of intracisternally-administered pergolide. Fed. Proc. 41: 7694, 1982.

49. Jadhav, A.L. and Lokhandwala, M.F.: Involvement of central and peripheral

dopaminergic mechanisms in the hypotensive and bradycardic effects of pergolide in the rat. Pharmacologist, 24: 63, 1982.

50. Ekas, R.D., Lokhandwala, M.F. and Steenberg, M.L.: Evidence for the presence of

presynaptic facilitatory beta-adrenoceptors on renal noradrenergic nerves. Brit. J. Pharmacol. 77: 407P, 1982.

51. Lokhandwala, M.F., Patel, U. P. and Jandhyala, B.S.: Central actions of pergolide on

neurogenic vascular tone in dogs. Fed. Proc. 42: 2777, 1983. 52. Jadhav, A.L., Willette, R.N., Sapru, H.N. and Lokhandwala, M.F.: Centrally-

mediated inhibition of peripheral sympathetic nerve activity by pergolide. Fed. Proc. 42: 3382, 1983.

53. Eikenburg, D.C. and Lokhandwala, M.F.: Influence of captopril on vascular

noradrenergic transmission in vivo in spontaneously hypertensive rats. Fed. Proc. 42: 5147, 1983.

54. Steenberg, M.L., Peter, E., Eikenburg, D.C., Jandhyala, B.S. and Lokhandwala, M.F.:

Effects of felodipine on sympathetic transmitter release and vasoconstrictor responses to exogenous norepinephrine in the isolated perfused rat kidney. Physiologist, 26: 8-15, 1983.

55. Alkadhi, K.A., Sabouni, M.H. and Lokhandwala, M.F.: Characterization of dopamine

receptors in a mammalian sympathetic ganglion. Fed. Proc. 43: 4731, 1984. 56. Sabouni, M.H. and Lokhandwala, M.F.: Effects of selective DAl- and DA2-receptor

agonists on responses to pre and postganglionic cardiac sympathetic nerve stimulation. Fed. Proc. 43: 4732, 1984.

57. Lokhandwala, M.F., Watkins, H. and Alkadhi, K.A.: Involvement of DA1-receptors in

the neurogenic vasodilation produced by SKF 82526 in the canine hindlimb. Fed. Proc. 43: 4733, 1984.

58. Adamski, S.W., Grega, G.J. and Lokhandwala, M.F.: Effects of dopamine and SKF

82526 on forelimb vascular resistance in dogs anesthetized with pentobarbital. Fed. Proc. 43: 4734, 1984.

59. Peter, E.J., Eikenburg, D.C. and Lokhandwala, M.F.: Effects of calcium antagonists

on pre and postsynaptic noradrenergic mechanisms in the rat kidney. Fed. Proc. 43: 961, 1984.

50

60. Peter, E.J., Eikenburg, D.C. and Lokhandwala, M.F.: Differential actions of calcium antagonists on pre and postjunctional noradrenergic mechanisms in the perfused rat kidney. Xth Scientific Meeting of the International Society of Hypertension. Abst. #694, 1984.

61. Lokhandwala, M.F., Sabouni, M.H. and Alkadhi, K.A.: Dopaminergic inhibition of

ganglionic transmission in spontaneously hypertensive rats: Implications for antihypertensive therapy with dopamine receptor agonists. Xth Scientific Meeting of the International Society of Hypertension. Abst. #554, 1984.

62. Lokhandwala, M.F., Watkins, H. and Alkadhi, K.A.: Pharmacological analysis of the

action of SKF 82526 on cardiovascular dopamine receptors. IUPHAR 9th International Congress of Pharmacology. Abst. #338, 1984.

63. Alkadhi, K.A., Sabouni, M.H. and Lokhandwala, M.F.: Characterization of ganglionic

dopamine receptors in spontaneously hypertensive and normotensive rats. IUPHAR 9th International Congress of Pharmacology Abst. #798, 1984.

64. Sabouni, M.H. and Lokhandwala, M.F.: Differential inhibition of pre and

postganglionic cardiac sympathetic neurotransmission by selective DA1 and DA2 receptor agonists. IUPHAR 9th International Congress of Pharmacology. Abst. #797, 1984.

65. Steenberg, M.L., Jandhyala, B.S. and Lokhandwala, M.F.: Effects of ouabain on [3H]-

norepinephrine release elicited during periarterial nerve stimulation in the perfused kidneys of SHR and WKY rats. IUPHAR 9th International Congress of Pharmacology. Abst. #1271P, 1984.

66. Lokhandwala, M.F. and Steenberg, M.L.: Presynaptic (DA2) and post-synaptic

(DA1) dopamine receptors in the rat kidney. Fed. Proc. 44: 4902, 1985. 67. Sengupta, S. and Lokhandwala, M.F.: Identification of dopamine receptor subtype(s)

involved in the hypotensive action of agonists by utilizing selective dopamine receptor antagonists. Fed. Proc. 44: 7212, 1985.

68. Sabouni, M.H., Alkadhi, K.A. and Lokhandwala, M.F.: Dopamine receptors in the

stellate ganglion of the dog. Fed. Proc. 44: 7213, 1985. 69. Kavukondala, G.B., Jandhyala, B.S. and Lokhandwala, M.F.: Effects of ouabain on

the release of norepinephrine and vascular reactivity in the rat kidney. Fed. Proc. 44:7733, 1985.

70. Lokhandwala, M. F., Sabouni, M. H. and Alkadhi, K. A.: Characterization of the

actions of felodopam in the dog hindlimb. Pharmacologist, 27: 579, 1985. 71. Lokhandwala, M. F., Hamed, A. T. and Jandhyala, B. S.: Evaluation of the role of

alpha-1 and alpha-2 adrenoceptors in the neurogenic regulation of hindlimb vascular tone in dogs. American Heart Association. Keystone, Colorado, February, 1986.

72. Alkadhi, K. A., Sabouni, M. H. and Lokhandwala, M. F.: Activation of dopamine

DA-1 receptors by dopamine or fenoldopam causes an increase in levels in the renal artery but not in the superior cervical ganglion of the rat, Fed. Proc. 45: 2386, 1986.

51

73. Sabouni, M. H., Ansari, A. F., Alkadhi, K. A. and Lokhandwala, M. F.: Electrophysiological and biochemical characterization of dopamine receptors in the canine stellate ganglia. Fed. Proc. 45: 2387, 1986.

74. Feldman, S. F., Weinheimer, A. J. and Lokhandwala, M. F.: Program for stimulation

of research careers in the pharmaceutical sciences. Amer. J. Pharm. Educ., 50: 295, 1986.

75. DeFeo, M. L., Jadhav, A. L. and Lokhandwala, M. F.: Urinary dopamine and sodium

excretion during the development of hypertension in Dahl rats. Clin. Exp. Hyperten., A9: 1089, 1987.

76. Sabouni, M. H., Alkadhi, K. A. and Lokhandwala, M. F.: Presynaptic and

postsynaptic dopamine receptors in rat superior cervical ganglion. Fed. Proc. 46: 126, 1987.

77. Lokhandwala, M. F., DeFeo, M. L. and Jadhav, A. L.: Relationship between salt

consumption and urinary dopamine and sodium excretion during the development of hypertension in Dahl rats. Fed. Proc. 46: 1199, 1987.

78. DeFeo, M. L., Lokhandwala, M. F. and Jandhyala, B. S.: Activation of central

dopaminergic mechanisms with pergolide triggers the release of an endogenous sodium-pump inhibitor and enhances vascular reactivity in anesthetized dogs. Fed. Proc. 46: 1201, 1987.

79. Watkins, H. O., Dlewati, A. and Lokhandwala, M. F.: Comparison of the effects of

dopamine receptor agonists fenoldopam and SK&F 85174 on hindlimb vascular resistance in anesthetized dogs. Fed. Proc. 46: 6649, 1987.

80. Dlewati, A., Watkins, H. O., Sabouni, M. H. and Lokhandwala, M. F.: Effects of

SK&F 85174, a dopamine receptor agonist, on pre and postganglionic sympathetic neurotransmission to the heart. Fed. Proc. 46: 6650, 1987.

81. Jadhav, A. L. and Lokhandwala, M. F.: A method for measuring the rate of dopamine

synthesis in the rat kidney cortex. Pharmacologist, 29: 532, 1987. 82. Feldman, S. F., Weinheimer, A. J. and Lokhandwala, M. F.: Directed career

development program for pharmacy students. Amer. J. Pharm. Educ., 51: 315-316, 1987.

83. Dlewati, A. and Lokhandwala, M. F.: Effects of intrarenal infusion of fenoldopam on

renal water and sodium excretion in pentobarbital-anesthetized dogs. FASEB J., 2: 1792, 1988.

84. Watkins, H. O., DeFeo, M. L., Dlewati, A. and Lokhandwala, M. F.: Effects of DA-1 receptor stimulation with fenoldopam on renal sodium excretion, plasma renin activity, plasma aldosterone and atrial natriuretic factor in anesthetized dogs. FASEB J., 2:1793, 1988.

85. Hegde, S. S. and Lokhandwala, M. F.: Contribution of endogenous dopamine in the

diuretic and natriuretic response to acute volume expansion in rats. Hypertension, 12:65, 1988.

86. Jadhav, A. L. and Lokhandwala, M. F.: Dietary sodium-induced changes in urinary

dopamine and electrolyte excretion in rats. Pharmacologist, 30:78.3, 1988.

52

87. Dlewati, A. and Lokhandwala, M. F.: Influence of alpha and beta adrenoceptors

blockade on the renal effects of fenoldopam. Pharmacologist, 30:152.4, 1988. 88. Hegde, S. S. and Lokhandwala, M. F.: Involvement of dopamine receptors in the

diuretic and natriuretic response to fenoldopam and acute volume expansion in anesthetized rats. Pharmacologist, 30:152.5, 1988.

89. Collier, W. L., Coppola, L., De Michele, M., Lokhandwala, M. F. and Amenta, F.:

Age-related changes of dopamine receptors in rat kidney. FASEB J., 3:2642, 1989. 90. Watkins, H. O., Staniciu, D. and Lokhandwala, M. F.: Renal and endocrine effects of

the DA-2 receptor agonist quinpirole in anesthetized dogs. FASEB J., 3:3881, 1989. 91. Dlewati, A. and Lokhandwala, M. F.: Dose-response analysis of hemodynamic and

renal effects of intravenous fenoldopam in pentobarbital-anesthetized dog. FASEB J., 3:3882, 1989.

92. Ricci, A., Amenta, F., Hegde, S. S. and Lokhandwala, M. F.: Autoradiographic

localization and functional characterization of renal dopamine receptors with fenoldopam. FASEB J., 3:3883, 1989.

93. Hegde, S. S. and Lokhandwala, M. F.: Activation of DA-1 but not DA-2 receptors by

endogenous dopamine contributes to the natriuretic response to acute volume expansion in rats. FASEB J., 3:3884, 1989.

94. Lokhandwala, M. F. and Hegde, S. S.: Renal dopamine receptors and natriuresis.

Proc. Soc. Exp. Biol. Med., 191:101, 1989. 95. Daver, R. G., Lokhandwala, M. F. and Jadhav, A. L.: Involvement of kidney

dopamine and plasma atrial natriuretic peptide in the natriuretic response to high sodium intake. Pharmacologists, 31:377, 1989.

96. Vyas, S. J. and Lokhandwala, M. F.: Role of tubular dopamine-1 receptors in the

natriuretic and diuretic response to dopexamine. Pharmacologist, 31:378, 1989. 97. Azad, A. K., Vyas, S. J., Hegde, S. S. and Lokhandwala, M. F.: Dopamine-1 but not

dopamine-2 receptor agonists cause natriuresis via activation of DA receptors. Proc. Soc. Exp. Biol. Med., 193: 246, 1990.

98. Vyas, S. J. and Lokhandwala, M. F.: Involvement of tubular dopamine-1 receptors in

the natriuretic and diuretic response to dopexamine in rats. Proc. Soc. Exp. Biol. Med., 193: 246, 1990.

99. Lokhandwala, M. F., Hegde, S. S., Ricci, A., Vega, J. and Amenta, F.: Role of renal

dopamine and DA-1 receptors in the natriuretic and diuretic response to atrial natriuretic factor. Kidney Int. 37: 341, 1990.

100. Lokhandwala, M. F. and Hegde, S. S.: Renal dopamine receptors and natriuresis:

Characterization of receptors and signal transduction systems. J. Auton. Pharmacol., 10: 5-6, 1990.

53

101. Vyas, S. J., Ricci, A., Amenta, F. and Lokhandwala, M. F.: Autoradiographic evidence for the role of dopamine-1 receptors in the natriuretic response to dopexamine. FASEB J. 4: 1977, 1990.

102. Watkins, H. O., Etumnu, P., Hegde, S. S. and Lokhandwala, M. F.: Renal effects of

dopamine-2 receptor agonist bromocriptine in dogs. FASEB J. 4: 1978, 1990. 103. Hegde, S. S., Ricci, A., Vega, J., Amenta, F. and Lokhandwala, M. F.: Evidence for

the role of endogenous renal dopamine and DA-1 receptors in the renal effects of atrial natriuretic factor. Europ. J. Pharmacol., 183: 1153, 1990.

104. Jadhav, A. L. and Lokhandwala, M. F.: Interactions between atrial natriuretic

peptides and renal dopamine during high sodium intake. Europ. J. Pharmacol., 183: 1051, 1990.

105. Ricci, A., Napoleone, P., Amenta, F., Vyas, S. and Lokhandwala, M. F.: Anatomical

localization of the binding and functional characterization of responses to dopexamine hydrochloride, a DA-1 and ß2-adrenoceptor agonist in the rat mesenteric vasculature. J. Auton. Pharmacol., 10 (Suppl 1):S129, 1990.

106. Jadhav, A. L., Lokhandwala, M. F., Ricci, A. and Amenta, F.: Alterations in kidney

dopamine production and dopamine receptors during increased sodium intake. J. Auton. Pharmacol., 10 (Suppl 1): S130, 1990.

107. Hegde, S. S. and Lokhandwala, M. F.: Stimulation of renal dopamine production

during acute volume expansion requires the presence of intact vagi but not renal nerves. J. Auton. Pharmacol., 10 (Suppl 1): S130, 1990.

108. Chen, C. J. and Lokhandwala, M. F.: A defect in renal tubular dopamine DA-1

receptor function causes diminished natriuresis to volume expansion in spontaneously hypertensive rats. FASEB J., 5: 1705, 1991.

109. Vyas, S. J., Eichberg, J. and Lokhandwala, M. F.: Identification of receptors involved

in dopamine induced activation of phospholipase-C in rat kidney. FASEB J., 5: 4038, 1991.

110. Lokhandwala, M. F. and Chen, C. J.: Diminished natriuresis to volume expansion in

spontaneously hypertensive rats is due to an impairment of tubular dopamine DA-1 receptor function. Hypertension, 17: 410, 1991.

111. Vyas, S. J., Eichberg, J. and Lokhandwala, M. F.: Modulation by dopamine of renal

phospholipase-C activity after increase in sodum intake. Hypertension, 18:405, 1991. 112. Chen,C.J., Vyas, S. J., Beach, R. E., Eichberg, J. and Lokhandwala, M. F. :

Diminished natriuresis to dopamine in spontaneously hypertensive rats is due to a defect in phospholipase-C mediated inhibition of Na+-K+-ATPase. J. Amer. Soc. Nephrol., 2:472, 1991.

113. Vyas,S.J., and Lokhandwala, M. F.: Identification of tubular and hemodynamic

components in the natriuretic response to dopamine. FASEB Journal, 6: 5316, 1992. 114. Chen, C.J., and Lokhandwala, M.F.: Dopamine-induced inhibition of Na+,K+-

ATPase in renal proximal tubule is mediated by DA-1 receptor activation. FASEB Journal, 6: 5317,1992.

54

115. Sakamoto,T., and Lokhandwala, M.F.: Lack of renal dopamine production during

acute volume expansion in prehypertensive Dahl rats. J. Hpertension, 10 (Suppl.4): S119, 1992.

116. Chen, C.J., and Lokhandwala, M.F.: Dopamine DA-1 receptor but not DA-2 receptor

is involved in DA-mediated inhibition of Na,K-ATPase in renal proximal tubule cells. J. Hypertension, 10 (Suppl.4): S119, 1992.

117. Chen, C.J., and Lokhandwala, M.F.: Identification of site(s) of defect in DA-1

receptor coupled phospholipase-C signaling pathway in the renal proximal tubule of SHR. Pharmacologist, 34: 46, 1992.

118. Jadhav, A.L., Liu, Q., and Lokhandwala, M.F.: Effect of volume and Na+

disturbances on renal cortical DA1 receptor affinity and density. Pharmacologist, 34: 325, 1992.

119. Chen, C.J. and Lokhandwala, M.F.: Defective dopamine (DA) DA-1 receptor coupled

signaling mechanisms cause loss of DA-induced inhibition of Na+,K+-ATPase in renal proximal tubule of SHR. J.Amer.Soc.Nephrol. 3:517,1992.

120. Jacinto, S.M., Lokhandwala, M.F. and Jandhyala, B.S.: Comparative effects of

dopexamine, dobutamine and prenalterol on free radical mediated toxicity induced by xanthine plus xanthine oxidase. FASEB Journal, 7: 2462, 1993.

121. Chen, C. J. and Lokhandwala, M. F.: Dopamine-induced inhibition of Na,K-ATPase

activity in renal proximal tubule involves DA-1 receptor coupled phospholipase-C signalling pathway. FASEB Journal, 7: 2624, 1993.

122. Jandhyala, P., Watkins, H. O., Chen, C. J. and Lokhandwala, M. F.: Intrarenal

prostaglandins are not involved in the diuretic and natriuretic response to DA-1 receptor agonist, fenoldopam. FASEB Journal, 7: 1434, 1993.

123. Gopalakrishnan, S .M., Chen, C. J. and Lokhandwala, M. F.: Identification of α1-

Adrenoceptor subtype(s) mediating norepinephrine-induced stimulation of sodium pump in renal proximal tubules. Hypertension, 22, 443, 1993.

124. Gopalakrishnan, S. M., Chen, C. J. and Lokhandwala, M. F.: α1-Adrenoceptor

subtypes involved in inositol trisphosphate and Na,K-ATPase stimulation in renal proximal tubules. J. Amer. Soc. Nephrol. 4:486, 1993.

125. Venkatakrishnan, U., Chen, C. J. and Lokhandwala, M. F.: Involvement of kidney

nitric oxide in the natriuretic response to dopamine-1 receptor stimulation. J. Amer. Soc. Nephrol. 4:571, 1993.

126. Chen, C. J., Venkatakrishnan, U. and Lokhandwala, M. F.: Antinatriuretic response to

intrarenally infused phenylephrine is mediated via α1-Adrenoceptor activation. J. Amer. Soc. Nephrol. 4:576, 1993.

127. Lokhandwala, M.F., Gopalakrishnan, S.M. and Chen, C.J.: α1-Adrenoceptor subtypes

involved in norepinephrine-induced stimulation of Na,K-ATPase activity in renal proximal tubules. J. Autonomic Pharmacol. 14: 21, 1994.

55

128. Chen, C.J. and Lokhandwala, M.F.: Noradrenergic modulation of Na,K-ATPase activity in the renal proximal tubules of spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. Supplement 1: S29, 1994.

129. Kansra,V., Chen, C. J. and Lokhandwala, M. F.: Dopamine fails to stimulate protein

kinase C activity in renal proximal tubules of spontaneously hypertensive rats. FASEB Journal., 9: 310, 1995.

130. Jacinto, S. M., Lokhandwala, M. F. and Jandhyala, B. S.: Lipid peroxidation and

respiratory depression are primary factors responsible for the lethal toxicity induced by oxygen free radicals in anesthetized rats. FASEB Journal, 9: 2452, 1995.

131. Pedemonte,C.H., Pressley,T.A. and Lokhandwala,M.F.: Amino acids located in the

amino terminal end of the rat Na-pump α-subunit are essential for the stimulation by protein kinase C. Biophysical J. 70: A138, 1996.

132. Lokhandwala, M.F., Kansra, V. and Hussain, T.: Dopamine and phospholipase A2 in

the inhibition of sodium pump in renal proximal tubules of spontaneously hypertensive rats. J. Hypertension, 14(Suppl 1):S40, 1996.

133. Hussain, T. and Lokhandwala, M.F.: Dopamine-1 receptor-Gq/11 protein coupling in

renal basolateral membrane and reduced Gq/11 α in spontaneously hypertensive rats. J. Hypertension, 14(Suppl 1):S131, 1996.

134. Bharatula, M., Hussain, T. and Lokhandwala, M. F.: Role of Gs and Gi proteins in the

biphasic response of proximal tubular sodium pump to angiotensin II. J. Amer. Soc. Nephrol. 7: 1627, 1996.

135. Hussain, T., Abdul-Wahab, R., Bharatula, M. and Lokhandwala, M. F.: Dopamine-2

receptor modulates angiotensin II response on renal Na,K-ATPase through heterologous desensitization. J. Amer. Soc. Nephrol. 7: 1678, 1996.

136. Kansra, V., Hussain, T. and Lokhandwala, M. F.: Alteration in dopamine-1 receptor

and G-proteins in Fischer 344 old rat kidney. J. Amer. Soc. Nephrol. 7: 1679, 1996. 137. Hussain, T. and Lokhandwala, M. F.: Increased expression of D1A dopamine receptor

protein in renal proximal tubular basolateral membranes from spontaneously hypertensive rats. J. Amer. Soc. Nephrol. 8: 300A, 1997.

138. Hussain, T., Abdul-Wahab, R. and Lokhandwala, M. F.: Bromocriptine, a D2-like

receptor agonist regulates dopamine-mediated inhibition of Na,K-ATPase in rat renal proximal tubules: The role of G proteins. J. Amer. Soc. Nephrol. 8: 439A, 1997.

139. Hussain, T., Kotak, D. D., Abdul-Wahab, R. and Lokhandwala, M. F.: A decrease in

dopamine D1-like receptors contributes to reduced inhibition of Na,K-ATPase activity in the proximal tubules of obese hypertensive rats. FASEB Journal, 12: 557, 1998.

140. Lokhandwala, M. F., Kotak, D. D. and Hussain, T.: Defective dopamine receptor

signal transduction in renal proximal tubules of obese hypertensive rats. J. Hypertension, 16: S72, 1998.

141. Hussain, T., Abdul-Wahab, R., Kotak, D. and Lokhandwala, M. F.: Dopamine

receptor preactivation causes an increase in Gs protein and a decrease in [3H] angiotensin II binding sites in proximal tubules. J. Hypertension, 16: S125, 1998.

56

142. Hussain, T., Beheray, S.A., Kotak, D.K., Abdul-Wahab, R. and Lokhandwala, M.F.:

Downregulation of dopamine receptors and G protein function in renal proximal tubules of obese Zucker rats. J. Amer. Soc. Nephrol. 9: A2045, 1998.

143. Beheray, S.A., Hussain, T. and Lokhandwala, M.F.: Altered expression and function

of G proteins in proximal tubules of old Fisher 344 rats. J. Amer. Soc. Nephrol. 9: A2139, 1998.

144. Becker, M.L., Hussain, T. and Lokhandwala, M.F.: Increased c-AMP inhibition by

angiotensin II in the proximal tubules of obese Zucker rats: Evidence for increased AT 1 receptor sensitivity in the obese rats. FASEB Journal, 13: A790, 1999.

145. Beheray, S.A., Hussain, T. and Lokhandwala, M.F.: Dopamine stimulates protein

kinase A through the activation of D1-like dopamine receptors in the renal proximal tubules. FASEB Journal, 13: A791, 1999.

146. Beheray, S.A., Hussain, T. and Lokhandwala, M.F.: Altered modulation of G proteins

by hormones and peptides in the renal proximal tubules of adult and old Fischer 344 rats. FASEB Journal, 13: A798, 1999.

147. Narkar, V., Hussain, T., Pedemonte, C. and Lokhandwala, M.: Dopamine activates

p42/44 MAP Kinase and promotes mitogenesis in opossum kidney cells. FASEB Journal, 13: LB118, 1999.

148. Hussain, T., Beheray, S. A. and Lokhandwala, M. F.: Defective dopamine receptor G

protein function contributes to reduced dopamine-mediated inhibition of Na,K-ATPase in proximal tubules of obese Zucker rats. Amer. J. Hypertension, 12: 68A, 1999.

149. Lokhandwala, M. F.: Dopamine and blood pressure regulation. Fundamental &

Clinical Pharmacol. 13 (Suppl.1): 60s, 1999. 150. Hussain,T., Kotak, D. K., Abdul-Wahab, R. and Lokhandwala, M. F.: Dopamine

receptor signal transduction in renal proximal tubules of obese Zucker rats. Clin. Exp. Pharmacol. Physiol. 26 (Suppl): S55, 1999.

151. Beheray, S., Hussain, T. and Lokhandwala, M. F.: Altered expression and stimulation

of G-proteins by hormones and peptides in renal proximal tubules old Fischer 344 rats. Clin. Exp. Pharmacol. Physiol. 26 (Suppl): S56, 1999.

152. Vieira-Coelho, M. A., Hussain, T., Soares-da-Silva, P. and Lokhandwala, M. F.:

Effect of aging and sodium diet on intestinal Na, K-ATPase activity and dopaminergic tonus in Fischer 344 rats. Clin. Exp. Pharmacol. Physiol. 26 ( Suppl ): S62, 1999.

153. Becker, M. L., Lokhandwala, M. F. and Hussain,T.: Increased angiotensin II

stimulation of Na,H-exchanger activity in the proximal tubules of obese Zucker hypertensive rats via a cAMP dependent pathway. J. Amer. Soc. Nephrol. 10: A2272, 1999.

154. Beheray, S. A., Kansra, V., Hussain, T. and Lokhandwala, M. F.: Diminished

natriuretic response to dopamine in old rats: Evidence of impaired dopamine receptor signaling pathway inhibiting the Na,H-exchanger. J. Amer. Soc. Nephrol. 10: A2273, 1999.

57

155. Narkar, V., Hussain, T., Pedemonte, C, and Lokhandwala, M. F.: Dopamine D2-like receptor stimulation causes activation of p44/42 MAP kinase pathway and promotes mitogenesis in opossum kidney cells. J. Amer. Soc. Nephrol. 10: A2516, 1999.

156. Asghar, M., Hussain, T. and Lokhandwala, M. F.: Dopamine D1-like receptor

activation causes phosphorylation of alpha-subunit of Na,K-ATPase in the proximal tubules via protein kinase C pathway. FASEB J. 14: A1549, 2001.

157. Narkar, V. A., Hussin, T. and Lokhandwala, M. F.: Dopamine D2-like (D2 and D4)

receptor activation leads to mitogenesis via p44/42 MAPK stimulation in Opposum kidney cells. FASEB J. 14: A1550, 2000.

158. Hussain, T., Becker, M., Beheray, S. and Lokhandwala, M.F.: Dopamine-mediated

inhibition of Na,H-exchanger in proximal tubules of obese Zucker rats. J. Hypertension 18:P40.20, 2000.

159. Narkar, V. A., Hussain, T. and Lokhandwala, M.F.: Activation of Dopamine D2 and

D3 receptors causes stimulation of Na+,K+,ATPase via a P44/42 MAPK pathway in renal proximal tubules. J. Amer. Soc. Nephrol. 11: A2235, 2000.

160. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Defective renal dopamine response

in old rats is due to elevated basal protein kinase C activity and phosphorylation state of Na,K-ATPase. J. Amer. Soc. Nephrol. 11: A2303, 2000.

161. Narkar, V.A., Hussain, T., Pedemonte, C. and Lokhandwala, M.F.: Evidence for

expression of dopamine D2 and D4 receptors in opossum kidney cells and the role of D2 receptors in mitogenesis. J. Amer. Soc. Nephrol. 11: A2342, 2000.

162. Hussain, T., Lokhandwala, M. F., Henegar, J., Henegar, L., & Hall, J. E.: Increased

Expression of Na,H-Exchanger and Na,K-ATPase in Renal Cortex of Obese Dogs Fed a High Fat Diet. FASEB J. 15:A134, 2001.

163. Narkar, V.A., Hussain, T. and Lokhandwala, M.F.: Activation of D2 and D3

Receptors Causes Stimulation of Na+,K+, ATPase Via a Tyrosine Kinase-p44/42 MAPK Pathway in Rat Proximal Tubules. FASEB J. 15:A571, 2001.

164. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Hyperphosphorylation of both

dopamine D1A receptor and Na,K-ATPase lead to defective dopamine response in old rats. FASEB J. 15:A929, 2001.

165. Menezes, M., Hussain, T. and Lokhandwala, M.F.: Identification of D2-Like

Dopamine Receptors in Rat Renal Proximal Tubular Brushborder and Basolateral Membranes: Role in the Inhibition of cAMP. J. Amer. Soc. Nephrol. 12: A2977, 2001.

166. Hussain, T., Menezes, M. and Lokhandwala, M.F.: Defective D1-Like Dopamine

Receptor Stimulation of Inositol Triphosphate (IP3) and Inhibition of Na,K-ATPase by Arachidonic Acid in the Proximal Tubules of Old Fischer 344 Rats. J. Amer. Soc. Nephrol. 12: A3032, 2001.

167. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Over-Expression pf PKC-β1 and -δ

Isoforms in Renal Proximal Tubules Leads to Increased Basal Phosphorylation and Diminished Inhibition on Na,K-ATPase by Dopamine in Old Rats. J. Amer. Soc. Nephrol. 12: A3050, 2001.

58

168. Narkar, V.A., Hussain, T. and Lokhandwala, M.F.: Dopamine D2-Like Receptor

Activation Causes Stimulation of Na+,K+,ATPase via Tyrosine Phosphorylation and Recruitment of Na+,K+,ATPase a1 Subunit in Proximal Tubules. J. Amer. Soc. Nephrol. 12: A3108, 2001.

169. Hussain, T. and Lokhandwala, M. F.: Defective D1-like receptor signaling contributes

to the inability of dopamine to inhibit sodium transporters in the proximal tubules of obese Zucker rats. Int J Obesity 25: S26, 2001.

170. Trivedi, M., Hussain, T. and Lokhandwala, M.F.: Dopamine D1-Like Receptor

Recruitment in Renal Proximal Tubules of Sprague Dawley Rats. FASEB J. 16:A197, 2002.

171. Asghar, M., Hussain, T. and Lokhandwala, M.F.: Increased Phosphorylation and

Down Regulation of D1A Receptor Contribute to the Defective Dopamine Response in Old Fischer 344 Rats. FASEB J. 16:A576, 2002.

172. Amenta, F., Hussain, T., Lokhandwala, M.F., Mignini, F., Ricci, A. and Tayebati, S.

K.: Changes with Aging in Dopamine Receptor Expression in the Rat Mesenteric Vasculature. FASEB J. 16:A933, 2002.

173. Umrani, D. N., Hussain, T. and Lokhandwala, M.F.: Rosiglitazone Treatment

Restores Renal Dopamine Receptor Function and Lowers Blood Pressure in Obese Zucker Rats. Amer. J Hypertension, 15:188A, 2002.

174. Banday, A. A., Asghar, M., Hussain, T. and Lokhandwala, M. F.: Insulin

Downregulates D1 Receptor Function in Primary Proximal Tubular Epitheal Cells from Rat Kidney. J. Amer. Soc. Nephrol. 13: 289A, 2002.

175. Trivedi, M., Hussain, T. and Lokhandwala, M. F.: Newly Recruited D1A Receptors

by Dopamine are Involved in the Inhibition of Na,K-ATPase in Renal Proximal Tubules. J. Amer. Soc. Nephrol. 13: 740A, 2002.

176. Lokhandwala, M. F., Banday, A., Umrani, D. and Hussain, T.: Rosiglitazone

Treatment Reverses Renal Dopamine D1- Receptor Downregulation, Normalizes D1 Receptor Function and Lowers Blood Pressure in Obese Zucker Rats. Hypertension, 40: 386, 2002.

177. Lokhandwala, M. F., Asghar, M. and Hussain, T.: Prevention of oxidative stress-

induced elevation of prtein kinase C activity with α-lipoic acid in the kidneys of old rats. Free Rad. Biol. Med. 33: S354, 2002.

178. Hussain, T., Umrani, D. and Lokhandwala, M.F.: Renal dopamine receptor function in

hyperinsulinemic rats. Clin. Exp. Hypertension, 25: 60, 2003. 179. Lokhandwala, M.F., Asghar, M. and Hussain, T.: Age-related changes in renal

dopamine receptor function. Clin. Exp. Hypertension, 25: 64, 2003. 180. Khera, A. and Lokhandwala, M.F.: Diminished diuretic and natriuretic response to

dopamine D1-like receptor agonist, SKF-38393 in obese Zucker rats. FASEB J. 17, 386.7, 2003

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181. Trivedi, M., Hussian, T. and Lokhandwala, M.F.: Newly recruited dopamine D1A receptor are functional and involved in the inhibition of Na,K-ATPase by dopamine in renal proximal tubules. FASEB J. 17, 393.6, 2003.

182. Banday, A. A., Asghar, M., Hussain, T. and Lokhandwala, M. F.: Insulin-mediated

uncoupling of dopamine D1 receptor fropm Gprotein as a mechanism for diminished inhibition of renal Na,K-ATPase by dopamine in obese Zucker rats. Amer. J. Hypertension, 16: 19A, 2003.

183. Trivedi, M., Khera, A., Hussain, T. and Lokhandwala, M.F.: Improvement in insulin

sensitivity with rosiglitazone restores recruitment, G-protein coupling and function of renal dopamine D1A receptors in obese Zucker rats. Hypertension, 42: 396, 2003.

184. Khera, A., Banday, A. and Lokhandwala, M.F.: Reduced dopamine D1-like receptor

expression and function in stretozotocin-induced diabetic rats. Hypertension, 42: 421, 2003.

185. Banday, A. A., Hussain, T. and Lokhandwala, M.F.: Impaired renal dopamine D1-

receptor function is induced by circulating factors and is not inherited in obese Zucker rats. Hypertension, 42: 423, 2003.

186. Banday, A.A., Hussain, T. and Lokhandwala, M.F.: Impaired renal dopamine D1

receptor function is aquired and not inherited in obese Zucker rats. J. Amer. Soc. Nephrol. 14:549A, 2003.

187. Banday, A.A., Hussain, T. and Lokhandwala, M.F.: Free fatty acid-induced

uncoupling of D1 receptors from G proteins contributes to diminished inhibition of renal Na, K- ATPase by dopamine. J. Amer. Soc. Nephrol. 14: 775A, 2003.

188. Asghar, M. and Lokhandwala, M.F.: Antioxidants reduce oxidative stress, normalize

PKC activity and reverse dopamine D1 receptor downregulation in proximal tubules of old rats. Free Rad. Biol. Med. 35: S31, 2003.

189. Banday, A. A. and Lokhandwala, M.F.: Antioxidant tempol restores renal dopamine

D1 receptor function in obese Zucker rats. Free Red. Biol. Med. 35, S31, 2003. 190. Marwaha, A., Banday, A. and Lokhandwala, M.F.: Impaired renal dopamine D1

receptor function in streptozotocin-induced diabetic rats. FASEB J. 18: 395.7, 2004. 191. Trivedi, M. and Lokhandwala, M.F.: Rosiglitazone treatment restores D1A receptor

signaling by correcting its hyperphosphorylation state in proximal tubules of obese Zucker rats. FASEB J. 18: 399.18, 2004.

192. Banday, A. A., Marwaha, A. and Lokhandwala M.F.: Tempol reduces oxidative

stress, improves insulin sensitivity, and restores renal dopamine D1 receptor-G protein coupling and function in obese Zucher rats. Amer. J. Hypertension, 17: 214A, 2004.

193. Banday, A. A., Marwaha, A. and Lokhandwala, M. F.: Tempol improves insulin

sensitivity and restores renal dopamine D1 receptor-G protein coupling and function in obese Zucker rats. Hypertension, 44: 531, 2004.

194. Lokhandwala, M. F. and Trivedi, M.: Insulin sensitizer, rosiglitazone, retores coupling

of D1A receptors to Gs-proteins by reducing GRK expression and

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hyperphosphorylation of D1A receptors in obese Zucker rats. Hypertension, 44: 531, 2004.

195. Banday, A. A., Marwaha, A. and Lokhandwala, M. F.: Hyperglycemia-induced

oxidative stress impairs renal dopamine D1 receptor function via protein kinase C activation and G protein coupled receptor kinase 2 translocation. Hypertension, 44: 559, 2004.

196. Asghar, M., Banday, A.A., Fardoun, R. and Lokhandwala, M.F.: Hydrogen Peroxide

causes uncoupling of dopamine D1 receptors from G-proteins via a mechanism involving PKC and GRK2 in cell cultures from renal proximal tubules. Free Rad. Biol. Med. 37: S60, 2004

197. Banday, A.A., Marwaha, A. and Lokhandwala, M.F.: Oxidative stress in

hyperglycemic rats causes renal dopamine D1 receptor hyperphosphorylation via PKC activation and GRK2 translocation. Free Rad. Biol. Med. 37: S67, 2004.

198. Banday, A. and Lokhandwala, M. F.: Glucose increases oxidative stress and protein

kinase C activity resulting in hyperphosphorylation of dopamind D1 receptor, uncoupling from G proteins and loss of agonist induced response. J. Amer. Soc. Nephrol. 15: 445A, 2004.

199. Marwaha, A. and Lokhandwala, M. F.: Oxidative stress contributes to reduced renal

dopamine D1 receptor function in hyperglycemic rats. FASEB Journal, 19: 90.2, 2005. 200. Asghar, M. and Lokhandwala, M. F.: Lowering of oxidative stress by tempol leads to

a decrease in age-associated increase in insulin resistance in Fischer 344 rats. Free Rad. Biol. Med. 39: S30, 2005.

201. Asghar, M., Fardoun, R.Z., Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-

induced activation of nuclear transcription facter NFkB and G-protein coupled receptor kinase 2 causes dopamine D1 receptor G-protein uncoupling in renal proximal tubules of old rats. J. Amer. Soc. Nephrol. 16, 374A, 2005.

202. Asghar, M., Zeyssig, R., Monjok, E., Kouamou, G., Ohia, S.E., Lokhandwala, M.F.

and Bagchi, D.: Effect of a novel hydroxycitric acid extract (HCA-SX) on oxidative stress, insulin resistance and brain serotonin levels in obese Zucker rats. FASEB J. 20: 655.4, 2006.

203. Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: Oxidative stress causes activation

of NF-kB in renal proximal tubules of spargue dawley rats. FASEB J. 20: 709.8, 2006. 204. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress induced renal D1 receptor

dysfunction causes salt sensitive hypertension in spague dawley rats. FASEB J. 20: 743.11, 2006.

205. Asghar, M., Fardoun, R. and Lokhandwala, M.F.: Oxidative stress and age-related

decline in renal dopamine D1 receptor function. Free Radical Research, 40: S84, 2006. 206. Banday, A.A. and Lokhandwala, M.F.: Impaired renal dopamine D1 receptor function

contributes to oxidative stress mediated hypertension. Free Radical Research, 40:S152, 2006.

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207. Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Chronic insulin treatment phosphorylates ά1 Na, K-ATPase subunit at serine 11/18 and reduces its activity involving phophotidylinositol-3-kinase dependent atypical Protein Kinase C ξ/λ activation. J Am Soc Nephrol 17: 296A, 2006.

208. Banday, A.A., Fasili, F.R. and Lokhandwala, M.F.: G-protein coupled receptor kinase

2 mediates high glucose induced renal dopamine D1 receptor desensitization by interacting with Gάq/11. J Am Soc Nephrol 17: 365A, 2006.

209. Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Oxidative stress induced renal

dopamine D1 receptor dysfunction involves NF-kB and protein kinase C activation. J Am Soc Nephrol 17: 450A, 2006.

210. Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: ERK1/2 and G-protein coupled

receptor kinase 2 are required for insulin induced heterologous dopamine D1 receptor desensitization in renal epithelial cells. J Am Soc Nephrol 17: 594A, 2006.

211. Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: NF-kB contributes to oxidative

stress-induced defective renal dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. J Am Soc Nephrol 17: 603A, 2006.

212. Liza, G., Asghar, M. and Lokhandwala, M.F.: Exercise reduces oxidative stress and

inflammation and increases D1 receptor numbers and G-protein activation in renal proximal tubules of old rats. J Am Soc Nephrol 17: 603A, 2006.

213. Banday, A.A., Muhammad, A.B. and Lokhandwala, M.F.: Mechanisms of oxidative

stress induced increase in salt sensitivity and development of hypertension in Sprague-dawley rats. Hypertension, 48: e56, 2006.

214. Lokhandwala, M.F., Marwaha, A., Trivedi, M. and Banday, A.A.: Oxidative Stress

and renal dopamine D1 receptor function in experimental diabetes. Clin Exp Hypertension, 29: 223, 2007.

215. George, L., Asghar, M., and Lokhandwala, M.F. Exercise Stimulates Transcription Factors

(Nrf2 & NF-κB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008.

216. Lokhandwala, M.F., Banday, A.A., Bhatt, S. and Javkhedkar, A.: Oxidative stress and

transcriptional regulation of angiotensin AT1 receptors in hypertension. Physiol. Res. 57: 54P, 2008.

217. Banday, A.A. and Lokhandwala, M.F.: Antioxidant mediated Nrf2 activation blocks NFkB

stimulation and prevents angiotensin AT1 receptor upregulation and hypertension during oxidative stress. Hypertension, 52: e58, 2008.

218. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced renal angiotensin AT1

receptor upregulation causes increased stimulation of sodium transporters in hypertension. Hyppertension, 52: e59, 2008.

219. Banday, A.A. and Lokhandwala, M.F.: Role of Nrf2 in prevention of renal angiotensin AT1

receptor upregulation and hypertension during oxidative stress. J. Amer. Soc. Nephrol. 19: 67A, 2008.

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220. George, L., Lokhandwala, M.F. and Asghar, M.: Role of NFkB and Nrf2 in exercise-induced restoration of renal dopamine D1 receptor function in aging. J. Amer. Soc. Nephrol. 19: 139A, 2008.

221. Asghar, M. and Lokhandwala, M.F.: Inflammation produced by lipopolysaccharide

downregulates renal Nrf2, compromises renal D1 receptor function and increases blood pressure during high salt intake. J. Amer. Soc. Nephrol. 19: 140A, 2008.

222. Banday, A. A. and Lokhandwala, M. F.: Loss of biphasic effect on renal Na/K-

ATPase by angiotensin II involves defective regulation of AT1 rec eptor-NO-cGMP signaling during oxidative stress. J. Amer. Soc. Nephrol. 19: 377A, 2008.

223. George, L., Asghar, M., and Lokhandwala, M.F. Exercise Stimulates Transcription

Factors (Nrf2 & NF-κB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008.

224. Banday, A. A. and Lokhandwla, M. F.: Antioxidant-mediated Nrf2 activation

prevents AT1 receptor upregulation, endothelial dysfunction and hypertension by abolishing NFkB activation during oxidative stress, J. Clin. Hypertension, 11:A2, 2009.

225. Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Vascular and Not Systemic

Oxidative Stress Precedes Development of Hypertension and Is Associated with NFκB Activation and AT1 Receptor Upregulation. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension.2009; 54: e26-e127 (P261)

226. Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Early Chronic Resveratrol

Treatment Reduces Blood Pressure and Vasoconstriction and Improves Endothelium-Dependent Vasorelaxations by Lowering Oxidative Stress in Spontaneously Hypertensive Rats. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension.2009; 54: e26-e127 (P268)

227. Bhatt, S., Banday, A.A. and Lokhandwala M.F.: Vascular oxidative stress, NFκB activation

and AT1 Receptor upregulation precede the development of hypertension in Spontaneously Hypertensive Rats (SHR) FASEB J. 2009 23:LB53 (Experimental Biology 2009)

228. Amenta, F., Bhatt, S., Nwankwo, I.E., Muhammad, A.B., Ricci,A., Tayebati,S.K., Tomassoni, D. and Lokhandwala, M.F.: Microanatomical Changes In The Brain Of Obese Zucker Rats: A Model Of Metabolic Syndrome 6th International Meeting on Vascular Dementia, Spain, 2009. (#327)

229. Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Higher renal AT1 receptor affinity

exaggerates Ang II induced Na/K-ATPase stimulation in spontaneously hypertensive rats. FASEB J. 24: LB707, 2010.

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230. Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal AT1 receptor upregulation, NHE3 overstimulation and hypertension. Hypertension, 56: e117, 2010.

231. Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress via nuclear factor kappa B

causes vascular angiotensin type 1 receptor upregulation and contributes to development of hypertension in SHR. Hypertension, 56: e154, 2010.

232. Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress impairs renal nitric

oxide signaling and ang II mediated biphasic Na/K-ATPase regulation in spontaneously hypertensive rats. Hypertension, 52: e164, 2010.

233. Chugh, G., Lokhandwala, M.F. and Asghar, M.: Age-associated oxidative stress alters renal

D1 and AT1 receptor functions and increases blodd pressure in old Fischer 344 X Brown Norway F1 rats. Hypertension, 56: e164, 2010.