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October 17, 2016

Curriculum Vitae

Lauren B. Krupp, M.D.

Department of Neurology,

NYU Langone Medical Center

Director, Multiple Sclerosis Division

240 East 38th Street, New York, NY 10016

Telephone: 646 501 7509; cell 631 942 3176; Assistant: 646-501-7526

Email: lauren.krupp@nyumc.org

Education

Year Degree Field Institution & Location

1973 Certificate University of Grenoble, Grenoble, France

1977 BA Biology Hampshire College, Amherst, Mass

1981 MD Medicine Albert Einstein College of Medicine, Bronx, NY

Internships and Residencies:

1981-82 Intern in Medicine, Westchester County Medical Center, NY

1982-84 Resident, Neurology, Albert Einstein College of Medicine, Bronx, NY

1984-85 Chief Resident, Neurology, Albert Einstein College of Medicine, Bronx, NY

Clinical and Research Fellowships:

1985-87 Fellow, Neuroimmunology, NIH Bethesda, Maryland

Licensure and Certification

1985 New York License Registration #159491

1986 American Board of Psychiatry and Neurology

Academic Appointments

1987-1993 Assistant Professor of Neurology, Stony Brook Medicine

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1993-1999 Associate Professor of Neurology, Stony Brook Medicine

1994-1999 Associate Professor of Psychology, Stony Brook Medicine

1999- 2015 Professor of Neurology, Stony Brook Medicine

2015 - Adjunct Professor of Neurology, Stony Brook Medicine

2015 - Professor of Neurology, New York University

Hospital Appointments

1990-2015 Co-Director MS Comprehensive Care Center, Stony Brook Medicine

1997- 2015 Director Neuropsychology Research, Stony Brook Medicine

2002-2015 Director, Lourie Center for Pediatric Multiple Sclerosis, Stony Brook

2015- Director, MS Comprehensive MS Care Center, NYU Langone

2015- Director, Pediatric MS Center, NYU Langone

2015 Attending, Tisch Hospital, NYU Langone

Other Professional Positions and Major Visiting Appointments

2004-2007 Founding Chair, International Pediatric MS Study group

2007-2011 Member, Steering Committee, International Pediatric MS Study group

2009-2013 Member NIH, NMSS, FDA task force: Common Date Elements in MS

2011- Member, Steering Committee International Society for Cognition in MS

2013- Member, NIH, FDA, NMSS task force on outcome measures MSOAC

2014- Member, Steering Committee, International Pediatric MS Study Group

2014- Member, Data Safety Monitoring Committee on Alemtuzimab in Pediatric

MS, (Genentech)

2014- Member, Steering Committee of Clinical trial of Fingolimod in Pediatric

MS (Novartis)

2014- Invited Lecturer for International Child Neurology Society Congress

Lecture for course on Leukodystrophy: Pediatric MS

Lecture for course on Pediatric MS: Cognitive function in pediatric MS

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Awards and Honors

M.D. granted with special distinction in research

Invited speaker for first International MS meeting ACTRIMS/ECTRIMS

Invited speaker for the International Neuro Rehabilitation Society

Course Leader on Fatigue for American Academy of Neurology

Fatigue scale selected for translation into 17 languages and chosen for

dissemination by the Educational Services Corporation

Leadership Award – National Multiple Sclerosis Society, 2000

Health Professional of the Year – National Multiple Sclerosis Society, 2002

Major Committee Assignments

2003-10 Founding Chair, International Pediatric MS Study Group

2006-07 Chair, Steering Committee, Network of Pediatric MS Centers of Excellence

2007- Chair, NMSS Long Island Chapter Clinical Advisory Board

2010- Member, International Pediatric MS Study Group Steering Committee

2005- Member, NMSS Health Care Policy grant submissions Review Committee

2005- Member, NMSS Clinical Care Committee

2000-2004 Member, NMSS Research Advisory Board, Slifka Longitudinal MS Study

2010-2011 Member, Clinical Advisory Group. Academy of Neurology. Neurologic Lyme

disease

2014 Reviewer, Abstracts for presentation at the European Committee for Treatment

And Research in MS (ECTRIMS) International meeting for October, 2014

Memberships, Offices and Committee Assignments in Professional Societies

American Neurological Association

International Neuropsychological Society

American Academy of Neurology

American Medical Association

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Multiple Sclerosis Consortium

American Association of Neurology

National Multiple Sclerosis Society

Principal Clinical and Hospital Service Responsibilities

Standing University Committees, Major Ad Hoc Committees

1992-96 Chair, Department of Neurology Quality Assurance Committee

1992-96 Liaison, University Hospital Quality Assurance Committee

1996-99 Member, University Hospital Research Committee

1999-03 Member, Appointment for Promotion and Tenure Committee

2003 - Chair, Department of Neurology APT Committee

Major Administrative Responsibilities

Ad hoc reviewer (2008) Neurological, Aging and Musculoskeletal Epidemiology Study Section

National Multiple Sclerosis Society, Dutch Multiple Sclerosis Research Society

Department of Defense: (Study Section on Psychosocial stress and Gulf War Syndrome)

National Institutes of Disability Rehabilitation Research (Center and Training Grant

Review board), Italian Multiple Sclerosis Society

Reviewer for: American Journal of Psychiatry, Archives of Psychiatry; Acta Neurologica

Scandinavia, Brain, Journal of Clinical Rheumatology, Journal of Neurologic Rehabilitation,

Journal of Neurology, Neurosurgery, and Psychiatry, Journal of Psychosomatic Research,

Journal of Neurological Sciences, Multiple Sclerosis Muscle and Nerve, Neurology, Patient

Care, Psychopharmacology, Psychosomatic Medicine,

Teaching Experience

Lectures given for medical students, residents in pediatrics, neurology, internal medicine, and

physician assistant students, psychology PhD students

Mentoring of faculty

2001-02 Syed Rizvi, MD

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2007-08 Mirjana Savatic, MD, PhD

2012-13 Nurcan Gursoy, MD

Seminars/Courses Taught

1990-93 Lyme Disease: Problems and pitfalls in diagnosis course, at Academy of

Neurology meetings

1993 Opportunistic viral infections of the nervous system: JC Virus and

Cytomegalovirus, at Academy of Neurology meeting

1993 Post infectious neurologic syndromes, at Academy of Neurology meeting

1993-95, 1997 Fatigue in neurologic disease: Course director, at Academy of Neurology

Breakfast Seminar

2002 Fatigue in multiple sclerosis: Course director, Academy of Neurology

Breakfast Seminar

2003 Pediatric multiple sclerosis: Course director, Academy of Neurology

Breakfast Seminar, Honolulu, Hawaii

2004 Pediatric multiple sclerosis: Course director, Academy of Neurology

Breakfast Seminar San Francisco, California

Mentoring of Graduate Students, Residents, Post-Doctoral Fellows

Mentor for MD with Recognition Project

2002 Madeline Fersch

2011 Tiffany Moadel

2014 Emily Taub

2015 Roxanne Troxell

Ph.D. Dissertations Supervised

1991 Lynn Lagenbach Psychology

Title: “Cognitive effects of pharmacologic therapy for fatigue in multiple sclerosis”

1994 Mark Geisler Psychology

Title: “Effects of cooling on cognitive functioning and evoked potentials in MS”

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1995 Elizabeth Gaudino Psychology

Boards and Community Organizations – National and International Service

1998- Member, Medical Advisory Board for the National Multiple Sclerosis Society

2004-07 Chair Steering Committee. International Pediatric MS Study group

2007-13 Member, Steering Committee, International Pediatric MS Study group

2009-13 Member, NIH, NMSS, FDA task force: Common Date Elements in MS

2011-13 Chair, Investigator initiated study of the safety of PVAC in brain gliomas

2011- Member, Steering Committee International Society for Cognition in MS

2011- Member, NMSS. Grant reviewer for Health Care Policy Committee

2012- Member. Phase III DSMB member Phase II/III Clinical Trial in Crohn’s Disease.

(Pfizer Corp)

2014- Member, NIH, FDA, NMSS task force on outcome measures MSOAC

2014- Steering Committee: PARADIGMS (Gilenya in Pediatric MS) clinical trial (Novartis)

2014- Member. DSMB for Terrikids (Teriflunomide for Pediatric MS), (Genzyme)

Bibliography

1. Krupp L, Brecher PF, Chobanian AV: The in vivo transformation of phospholipid

vesicles to a particle resembling HDL in the rat. Biochem Biophys Res Commun

1976;72:1251-8

2. Zimmerman EA, Krupp L, Hoffman DL, Matthew E, Nilaver G: Exploration of

peptidergic pathways in brain by immunocytochemistry. A ten year perspective.

Peptides 1981;1:3-10

3. Hoffman DL, Krupp L, Schrag D, Nilaver G, Valiquette G, Kilcoyne MM,

Zimmerman EA: Angiotensin immunoreactivity in vaspressin cells in rat

hypothalamus and its relative deficiency in homozygogous Brattleboro rat. Ann NY

Acad Sci 1982;394:135-141

4. Wormser GP, Duncanson F, Krupp L: Acquired immune deficiency (AIDS) in

prison inmates - New York and New Jersey. MMWR 1983;31:700-701

5. Wormser GP, Krupp LB, Duncanson F, Hanrahan SP, Gavis G, Spira TJ,

Cunningham-Rundles S: Acquired immunodeficiencies in male prisoners – New

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insights into an emerging syndrome. Ann Intern Med 1983;98:297-303

6. Krupp LB, Lipton RB, Swerdlow ML, Leeds NE, Llena J: Progressive multifocal

leukoencephalopathy: Clinical and radiographic features. Ann Neurol

1985;17:344-349

7. Portenoy RK, Krupp LB, Kanner R: Neurologic consultation in the management of

patients with systemic cancer admitted to a community hospital. Cancer Investigation

1986;4:293-297

8. Krupp LB, Wormser GP, Gelberg EA: Prisoners as medical patients. Am J Pub Health

1987;77:859-60

9. Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC: Clinical characteristics of

fatigue in multiple sclerosis. Arch Neurol 1988;45:435-437

10. Lipton RB, Krupp LB, Horupian D, et al: Progressive multifocal

leukoencephalopathy of the posterior fossa in an AIDS patient: Clinical, radiographic,

and evoked potential findings. Eur Neurology 1988;28:258-261

11. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD: The fatigue severity scale

applied to patients with multiple sclerosis and systemic lupus erythematosus. Arch

Neurol 1989;46:1121-1123

12. Rapcsak SZ, Krupp LB, Rubens AB, Reim J: Mixed transcortical aphasia without

anatomical isolation of the speech area. Stroke 1990;21:953-956

13. Krupp LB, LaRocca NG, Muir J, Steinberg AD: Fatigue characteristics in systemic

lupus erythematosus. J Rheumatol 1990;17:1450-2

14. Coyle PK, Schutzer SE, Belman AL, Krupp LB, Golightly MG: CSF immune

complexes in patients exposed to B. Burgdorferi: Borrelia specific and non specific

immune complexes. Ann Neurol 1990;28:739-744

15. Halperin JJ, Krupp LB, Golightly MG, Volkman DJ: Lyme Borreliosis associated

encephalopathy. Neurology 1990;40:1340-1343

16. Krupp LB, Mendelson W, Friedman R: Chronic Fatigue Syndrome; An overview.

J. Clin Psychiatry 1991;52:403-410

17. Krupp LB, Mendelson WB: Sleep disorders in chronic fatigue syndrome. Sleep

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1990;(suppl):261-263

18. Krupp LB, Masur D, Schwartz D, Coyle P, Fernquist S, Langenbach L, Halperin J:

Cognitive Functioning in Lyme Borreliosis. Arch Neurology 1991;52:403-410

19. Coyle PK, Schutzer SE, Belman AL, Krupp LB, Deng Z: Cerebrospinal fluid

immunological parameters in neurologic lyme disease. Current Communications in

Cell and Molecular Biology 1992;6:31-43

20. Coyle PK, Deng Z, Belman AL, Schutzer SE, Krupp LB, Luft B: Detection of

Borrelia burgdorderi antigens in cerebrospinal fluid. Neurology 1993;43:1093-1097

21. Coyle PK, Krupp LB, Doscher: Significance of reactive Lyme serology in multiple

sclerosis. Ann Neurol. 1993;34:745-747

22. Pepper C, Krupp LB, Friedberg F, Doscher C, Coyle PK: Comparison of psychiatric

characteristcs in chronic fatigue syndrome, multiple sclerosis and depression. Journal

of Neuropsychiatry and Clinical Neurosciences 1993;5:1-7

23. Schwartz JE, Jandorf L, Krupp LB: The Measurement of Fatigue: A new instrument.

J Psychosom Res 1993;37:753-762

24. Krupp LB, Jandorf L, Coyle PK, Mendelson WB: Sleep in Chronic Fatigue. J

Psychsom Res 1993;37:325-331

25. Krupp LB, Masur DM, Kaufman LD: Neurocognitive dysfunction in the eosinophilia

myalgia syndrome. Neurology 1993;43:931-936

26. Krupp LB, Sliwinski M, Masur D, Friedberg F, Coyle PK: Cognitive functioning and

depression in patients with chronic fatigue syndrome and multiple sclerosis. Arch

Neurol 1994;51:705-710

27. Friedberg F, Krupp LB: A comparison of cognitive behavioral treatment for chronic

fatigue syndrome and primary depression. Clin Infec Dis 1994;18 (Supp l1):105-110

28. Stone AA, Broderick JE, Porter LS, Krupp LB, Gnys M, Paty J, Shiffman S: Fatigue

and mood in chronic fatigue syndrome patients: results of an momentary assessment

protocol examining fatigue and mood levels and diurnal patterns. Annals Behavioral

Medicine 1994;16:228-234

29. Coyle PK, Krupp LB, Doscher C, Amin K: Borrelia burgdorferi reactivity in patients

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with severe persistent fatigue who are from a region in which lyme disease is

endemic. Clinical Infectious Diseases 1994;18 (Supp l ):S24-S27

30. Kaufman LD, Kaufman MA, Krupp LB: Movement disorders in eosinophilia

myalgia syndrome, tremor, myoclonus, myokymia. J Rheumatology 1995;22:157-160

31.Gaudino EA, Masur DM, Kaufman LD, Sliwinski M, Krupp LB: Depression and

neuropsychological performance in eosinophilia myalgia syndrome: A

comprehensive analysis of cognitive function in a chronic illness. Neuropsychiatry,

Neuropsychology and Behavioral Neurology 1995;8:118-126

32. Coyle PK, Schutzer SE, Deng Z, Krupp LB, Belman AL, Benach JL, Luft BJ.

Detection of Borrelia burgdorferi specific antigen in antibody-negative cerebrospinal

fluid in neurologic Lyme disease. Neurology 1995;45:2010-2015

33. Krupp LB, Coyle PK, Doscher C, Miller A, Cross AH, Jandorf L, Halper J, Johnson

B, Morgante L, Grimson R: Fatigue therapy in multiple sclerosis: results of a double

blind randomized parallel trial of amantadine, pemoline and placebo. Neurology

1995;45:1956-1961

34. Ettinger AB, Weisbrot, D, Andriola MA, Krupp LB, Jandorf L: Felbmate induced

headache. Epilepsia 1996;37:503-505

35. Geisler MW, Sliwinski M, Coyle PK, Masur DM, Doscher C, Krupp LB: The effects

of amantadine and pemoline on cognitive functioning in multiple sclerosis. Arch

Neurol 1996;53:185-1886.

36. Geisler MW, Sliwinski M, Coyle PK, Masur DM, Doscher C, Krupp LB: Cooling

and multiple sclerosis: cognitive and sensory effects. J Neurol Rehab 1996;10:17-22

37. Coyle PK, Krupp LB, Doscher C, Deng Z, Milazzo A: Clinical and immunological

effects of cooling in multiple sclerosis. J Neurol Rehab 1996;10:9-15

38. Krupp LB, Pollina DA: Mechanisms and management of fatigue in progressive

neurological disorders. Current Opinion in Neurology 1996;9:456-460

39. Miller AE, Morgante LA, Buchwald LY, Nutile SM, Coyle PK, Krupp LB, Doscher

CA: A multicenter, randomized, double-blind placebo-controlled trial of influenza

immunization in multiple sclerosis. Neurology 1997;48:312-314

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40. Gaudino E, Coyle PK, Krupp LB: Post Lyme syndrome and chronic fatigue

syndrome: neuropsychiatric similarities and differences. Arch Neurol 1997;

54:1372-1376

41. Schutzer S, Coyle PK, Krupp LB, Deng Z. Belman AL, Dattwyler R, Luft BJ: Cerebrospinal fluid

in central nervous system invasion in early Lyme disease. J Clin Invest 1997;100:763-767

42. Ettinger AB, Wesbrot DM, Krupp LB. Fatigue in Epilepsy J. Epilepsy

1998;11:105-109

43. Epstein SA, Kay G, Clauw D, Heaton R, Klein, D, Krupp L, Kuck J, Leslie V, Masur

D, Wagner M, Waid R, Zisook S: Psychiatric disorders in patients with fibromyalgia:

a multicenter investigation. Psychosomatics 1999;40:57-63

44. Pollina DA, Kaufman LD, Masur DM, Krupp LB: Cognition, sleep and pain in

Eosinophilia-Myalgia Syndrome: Inter-relationships. J Neuropsychiatry and Clin

Neurosciences 1998;10:338-341

45. Pollina DA, Elkins L, Squires NK, Scheffer S, Krupp LB: Does process-specific

slowing account for cognitive deficits in Lyme disease. Applied Neuropsych

1999;6:27-32

46. Elkins LE, Pollina DA, Scheffer S, Krupp LB: Psychological states and

neuropsychological performances in chronic Lyme disease. Applied Neuropsych

1999;6:19-26

47. Pollina DA, Sliwinski M, Squires NK, Krupp LB: Cognitive processing speed

in Lyme disease. Neuropsychiatry Neuropsychol Behav Neurol 1999;12:1-12.

48. Jacobs L, Wende KE, Brownscheidle CM, Apatoff B, Coyle PK, Goodman A,

Gottesman MH, Granger CV, Greenberg SJ, Herbert J, Krupp LB, Lava NS, Mihai C,

Miller AE, Perel A, Snyder DH, New York State Multiple Sclerosis Consortium: A

profile of multiple sclerosis: the New York State multiple sclerosis consortium.

Multiple Sclerosis 1999;5:369-376

49. Elkins L, Krupp L, Scherl W: The measurement of fatigue and contributing

neuropsychiatric factors. Seminars in Clinical Neuropsychiatry 2000;4:58-61

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50. Krupp LB, Elkins L, Coyle PK Pollina D, Masur DM: Post Lyme Syndrome:

Contrasts with recovered Lyme patients on cognitive and symptom measures. Journal

of Spirochetal Diseases 2000;6:112-116

51. Krupp LB, Elkins LE: Fatigue and declines in cognitive functioning in multiple

sclerosis. Neurology 2000;55:934-939

52. Kleinman L, Zodet M, Hakim Z, Aledort J, Barker C, Chan K, Krupp L, Revicki D:

Psychometric evaluation of the Fatigue Severity Scale for use in chronic hepatitis C.

Quality of Life Research Quality of Life Research 2000;9:499-508

53. Schwid S, Goodman A, Apatoff B, Coyle P, Jacobs L, Krupp L, Miller A, Wende K,

Brownscheidle C, New York State Multiple Sclerosis Consortium: Quantitative

functional measures are more sensitive to worsening MS than traditional measures.

Neurology 2000;55:1901-1903

54. Pan JW, Krupp LB, Elkins L, Coyle PK: Cognitive dysfunction lateralizes with NAA

in multiple sclerosis. Applied Neuropsychology 2001;8:155-160

55. Krupp LB, Christodoulou C: Fatigue in multiple sclerosis. Current Neurology and

Neuroscience Reports 2001;1:295-298

56. Krupp LB, Rizvi S:. Symptomatic therapy for underrecognized manifestations of

multiple sclerosis. Practical Issues in the Management of Multiple Sclerosis.

Neurology 2002;58:S32-39

57. Pan J, Coyle PK, Bashir K, Whitaker JN, Krupp LB, Hetherington HP. Metabolic

differences between multiple sclerosis subtypes measured by quantitative MR

spectroscopy. Multiple Sclerosis 2002;8:200-206.

58. Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, Ahnn S, Dattwyler R, Chandler B. Study

Treatmen of Lyme Disease (STOP-LD) randomized double masked clinical trial. Neurology.

2003;60:1923-1930

59. Christodoulou, C, Krupp LB, Liang Z, Huang W, Melville P, Roque C, Scherl WF, Morgan T,

MacAllister WS, Li L, Tudorica LA, Li X, Roche P, Peyster RCognitive performance and

neuroimaging markers of injury in cognitively impaired MS patients. Neurology

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2003;60:1793-1798

60. Weinstock-Guttman B, Jacobs LD, Brownscheidle CM, Baier M, Rea DF, Apatoff BR. Krupp L,

Munschauer FE, Rubin D, Schwid S, Smiroldo J and the New York State Consortium.

Multiple sclerosis characteristics in African American patients in New York State. Multiple

Sclerosis 2003;9:293-298

61. Krupp LB. Fatigue in MS: Pathophysiology, Measurement and Management. CNS

Drugs 2003;17:225-234

62. Lihong Li, Ixang Li, Honging Lu, Wei Huang, Christodoulou C, Tudoriaca A,

Krupp LB, Zhengrong Liang. MRI Volumetric Analysis of Multiple

Sclerosis: Methodology and Validation. IEEE Transactions on Nuclear Science

2003;50:1686-1692

63. Krupp LB, Christodoulou C, Melville P, Scherl WF, MacAllister WS, Elkins LE.

Donepezil improved memory in multiple sclerosis in a randomized clinical trial.

===Neurology 2004;63:1579-1585

64. Scherl WF, Krupp LB, Christodoulou C, Morgan T, Hyman L, Chandler B, Coyle PK,

MacAllister WS, and the Lyme Study Group. Normative data for the selective reminding test:

A random digit dialing sample. Psychological Reports 2004; 95:593-603

65. MacAllister W, Belman AL, Milazzo M, Weisbrot D, Christodoulou C, Preston T,

Cianciulli C, Krupp LB. Cognitive Functioning in Pediatric Multiple Sclerosis.

Neurology 2005;64:1422-5

66. Christodouldou C, Melville P, Scherl W, Morgan T, MacAllister WS, Canfora D,

Krupp LB. Perceived cognitive dysfunction and observed neuropsychological performance:

longitudinal relation in persons with multiple sclerosis. JINS 2005;11:614-619

67. Gladstone DE, Zamkoff KW, Krupp L, Peyster R, Sibony P, Christodoulou C, Locher E, Coyle

PK. High-dose cyclophosphamide for moderate to severe refractory multiple sclerosis.

Archives of Neurology 2006;6310:1388-96

68. Banwell B, Reder AT, Krupp L Eraksoy M, Alexey B, Pohl D, Freedman M, Schelensky L,

Antonijevic I.Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis: A

Multicenter Study. Neurology 2006;66:472-6

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69. Friedman JH, Brown RB, Comella C, Garber CE, Krupp LB, Lou J, Marsh L, Nail L,

Shulman L, Taylor CB. Fatigue in Parkinson’s Disease: A Review. Movement Disorders

2007; 22:297-308

70. Krupp, LB, Banwell B, Tenembaum. International Pediatric MS Study Group. Consensus

definitions proposed for pediatric multiple sclerosis and related disorders. Neurology

2007;68:S7-S12.

71. MacAllister WS, Christodoulou C, Milazzo M, Krupp LB. Longitudinal neuropsychological

assessment in pediatric multiple sclerosis. Developmental Neuropsychology 2007; 32:625-

644.

72. Banwell B, Krupp L, Kennedy J. Tellier R, Tenembaum S, Ness J, Belman A, Boiko A, Bykova

O, Waubant E, Mah JK, Stoian C, Kremenchutzky M, Bardini MR, Ruggieri M, Rensel M, Hahn

J, Weinstock-Guttman B, Yeh EA, Farrell K, Freedman M, Iivanainen M, Sevon M, Bhan V,

Dilenge ME, Stephens D, Bar-Or A.Clinical features and viral serologies in pediatric

multiple sclerosis: results of a multinational study. Lancet Neurology 2007;6(9):773-81

73. MacAllister WS, Milazzo M, Holland N, Krupp LB. Psychosocial features of pediatric MS.

Neurology 2007;68:S66-S70

74. Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp L, Gronseth

G, Bever CT Jr. Practice parameter: treatment of nervous system Lyme disease (an evidence-

based review): report of the Quality Standards Subcommittee of the American Academy of

Neurology. Neurology 2007; 69:91-102

75. Lerdal A, Celius EG, Krupp L, Dahl AA. A prospective study of patterns of fatigue in multiple

sclerosis. European Journal of Neurology 2007;14:1338-43

76. Banwell B, Bar-Or A, Cheung R, Kennedy J, Krupp LB, Becker DJ, Dosch HM, Wadsworth

Pediatric Multiple Sclerosis Study Group. Abnormal T-cell reactivities in childhood

inflammatory demyelinating disease and type 1 diabetes. Annals of Neurology 2008;63:98-

111

77. Christodoulou C, MacAllister WS, McLinskey NA, Krupp LB. Treatment of cognitive

impairment in multiple sclerosis: Is the use of acetylcholinesterase inhibitors a viable

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option? CNS Drugs 2008;22:87-97

78. Vanner EA, Block P, Christodoulou CC, Horowitz BP, Krupp LB. Pilot study exploring

quality of life and barriers to leisure-time physical activity in persons with moderate to

severe multiple sclerosis. Disability and Health Journal 2008;1:58-65

79. Jacob A, Weinshenker BG, Violich I, McLinskey N, Krupp L, Fox RJ, Wingerchuk DM, Boggild

M, Constantinescu CS, Miller A, DeAngelis T, Matiello M, Cree BA. Treatment of

neuromyelitis optica with rituximab: Retrospective analysis of 25 patients. Archives of

Neurology 2008;65:E1-E6

80. Goodman AD, Brown TR, Cohen JA, Krupp LB, Schapiro R, Schwid SR, Cohen R, Marinucci LN,

Blight AR, Fampridine MS-F202 Study Group. Dose comparison trial of sustained-release

fampridine in multiple sclerosis. Neurology 2008; 71(15):1134-1141

81. Maletic-Savatic M, Vingara LK, Manganas LM, Li Y, Zhang S, Sierra A, Hazel A, Smith D,

Wagshul ME, Henn F, Krupp LB, Enikolopov G, Benveniste H, Djuric PM, Pelczer I

Metabolomics of neural progenitor cells: a novel approach to biomarker discovery. Cold

Spring Harbor Symposia on Quantitative Biology. 2008. 73:159-172.

82. Patrick E, Christodoulou C, Krupp LB. on behalf of the New York State Multiple Sclerosis

Consortium,Longitudinal correlates of fatigue in multiple sclerosis. Multiple Sclerosis,

2009.15: 258–261.

83. Christodoulou C, Melville P, Scherl WF, MacAllister WS, Abensur RL, Troxell RM, Krupp LB.

Negative affect predicts subsequent cognitive change in multiple sclerosis over one year.

Journal of the International Neuropsychological Society, 2009:15, 53-61.

84. Goodman AD, Brown TR, Krupp LB, Schapiro RT, Schwid SR, Cohen R, Marinucci LN, Blight

AR, for the Fampridine MS-F203 Study Group. Randomized, double-blind, placebo-

controlled trial of sustained release oral fampridine in multiple sclerosis. Lancet,

2009.373:732-738

85. Rithidech KN, Honikel L, Milazzo M, Madigan D, Troxell R, Krupp LB. Protein expression

profiles in pediatric multiple sclerosis: potential biomarkers. Multiple Sclerosis 2009 15:

455-464

86. Block P, Rodriguez E, Milazzo M, MacAllister W, Krupp L, Nishida A, Slota N, Broughton A,

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Keys CB. Building pediatric multiple sclerosis community using a disability studies

framework of empowerment. Research in Social Science and Disability 2011;6:85-112

87. MacAllister WS, Christodoulou C, Troxell R, Milazzo M, Block P, Bender HA, Belman A, &

Krupp LB Fatigue and Quality of Life in Pediatric Multiple Sclerosis. Multiple Sclerosis. 2009;

15; 1502-1508

88. Weisbrot DM, Ettinger AB, Gadow KD, Belman AL, MacAllister WS, Milazzo M, Reed ML,

Serrano D, Krupp LB. Psychiatric comorbidity in pediatric patients with demyelinating

disorders. Journal of Child Neurology 2010;25: 192-202

89. Krupp, LB, Serafin, DJ, Christodoulou, C. Multiple sclerosis-associated fatigue. Expert Review

of Neurotherapeutics;2010: 10:1437-1447

90. Chabas, D. Ness J. Belman, A. Yeh A. Kuntz N, Gorman MP, Strober JB, De Kouchkovsky I,

McCulloch C. Chitnis, T. Rodriguez M. Weinstock-Guttman B., Krupp LB, and

Waubant E. Younger children with pediatric MS have a distinct CSF inflammatory profile at

disease onset. Neurology. 2010. 74:399-405

91. Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman L, McDonald JC,

Oksenberg JR, Bacchetti P, Waubant E. Vitamin D status is associated with relapse

rate in pediatric-onset MS. Annals of Neurology 2010;67:618-624

92. Kister I, Chamot E, Bacon JH, Niewczyk PM, DeGuzman RA, Apatoff B, Coyle P, Goodman AD,

Gottesman M, Granger C, Jubelt B, Krupp L, Lenihan M, Lublin F, Mihai C, Miller A,

Munschauer FE, Perel AB, Teter BE, Weinstock-Guttman B, Zivadinov R, Herbert J. Rapic

disease course in African Americans with multiple sclerosis. Neurology 2010;75:217-223

93. Yeh EA, Waubant E, Krupp L, Ness J, Chitnis T, Kuntz N, Ramanathan M, Belman A, Chabas

D, Gorman M, Rodriguez M, Rinker J, Weinstock-Guttman B. MS Therapies in Pediatric MS

Patients With Refractory Disease. Archives of Neurology 2011 April;68(4):437-444

94. Mowry EM, James JA, Krupp LB, Waubant E. Vitamin D Status and antibody levels to

common viruses in pediatric-onset multiple sclerosis. Multiple Sclerosis 2011 Jan 6 (Epub)

95. Smerbeck AM, Parrish J, Serafin D, Yeh EA, Weinstock-Guttman B, Hoogs M, Krupp L,

Benedict RHB. Visual-cognitive processing deficits in pediatric multiple sclerosis. Multiple

Sclerosis, 2011 April;17(4):449-456

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96. Krupp, LB, Christodoulou C, Melville P, Scherl WF, Pai L, Muenz L, He D, Benedict R,

Goodman AD, Rizvi S, Schwid SR, Weinstock-Guttman B, Westervelt HJ, Wishart HA. A

multi-center randomized clinical trial of donepezil for memory impairment in multiple

sclerosis. Neurology 2011;76(17):1500-1507

97. Smerbeck AM, Parrish J, Yeh EA, Hoogs M, Krupp L, Weinstock-Guttman B,

Benedict RHB. Regression-based pediatric norms for the Brief Visuospatial

Memory Test – Revised and the Symbol Digit Modalities Test. Clinical

Neuropsychologist 2011 April;25(3):402-12

98. Waubant, E, Mowry EM, Krupp LB, Chitnins T, Yeh EA, Kuntz N, Ness J, Chabas D, Strober J,

McDonal J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman, B, Rodriguez M,

Oksenberg JR, James JA, and for the US Pediatric MS Network. Common viruses associated

with lower pediatric multiple sclerosis risk Neurology, 2011 76:1989-1995

99. MacAllister, W.S., Christodoulou, C., Milazzo, M.C., Preston, T., Serafin, D., Krupp, L.,

Harder, L. Pediatric Multiple Sclerosis: What We Know and Where Are We Headed? Child

Neuropsychology, 2012 March

100.Wagshul ME, Yu HJ, Christodoulou C, Bhise V, Greenblatt D, Patel Y, Serafin D,

Maletic-Savatic M, Krupp LB. Multiple white matter tract abnormalities underlie

cognitive impairment in RRMS. NeuroImage, 2012 February. 59(4):3713-3722

101.Chitnis T, Tenembaum S, Banwell B, Krupp L, Pohl D, Rostasy K, Yeh EA, Bykova O,

Wassmer E, Tardieu M, Kornberg A, Ghezzi A for the International Pediatric Multiple

Sclerosis Study Group. Consensus statement: evaluation of new and existing therapeutics

for pediatric multiple sclerosis. Multiple Sclerosis, 2012 January;18(1):116-27

102.Langdon DW, Amato MP, Boringa J, Brochet B, Foley F, Fredrikson S, Hamalainen P,

Hartung HP, Krupp L, Penner IK, Reder AT, Benedict RHB. Recommendations for a

Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Multiple

Sclerosis, 2012;18(6):891-898

103. Smerbeck, Parrish, Yeh EA, Weinstock-Guttman B, Hoogs, Serafin D, Krupp L,

Benedict R. Regression-based Norms Improve the Sensitivity of the National MS

Society Consensus Neuropsychological Battery for Pediatric Multiple Sclerosis (NBPMS).

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Clinical Neuropsychologist, 2012 August. 26(6):985-1002

104. Benedict R, Amato MP, Boringa J, Brochet B, Foley F, Fredrikson S, Hamalainen P,

Hartung H, Krupp L, Penner I, Reder A, Langdon D. Brief International Cognitive

Assessment for MS (BICAMS): international standards for validation.

BMC Neurology, 2012;12:55

105. Kluger, BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurological illnesses:

Proposal for a unified taxonomy. Neurology, 2013;80:409

106. Julian L, Serafin D, Charvet L, Ackerson J, Benedict RHB, Braaten E, Brown T, O’Donnell

EH, Parrish J, Preston T, Zaccariello M, Belman A, Chitnis T, Gorman M, Ness J, Patterson

M, Rodriguez M, Waubant E, Weinstock-Guttman B, Yeh A, Krupp LB, on behalf of the

Network of Pediatric MS Centers of Excellence. Cognitive impairment occurs early in

pediatric multiple sclerosis: Results from a US network. Journal of Child Neurology, 2013;

28:102-107

107. Amato MP, Langdon D, Montalban X, Benedict RH, Deluca J, Krupp LB, Thompson AJ, Comi

G. Treatment of cognitive impairment in multiple sclerosis: position paper. J Neurol. 2012

Nov 23 [Epub ahead of print]

108. Chitnis T, Tardieu M, Amato MP, Banwell B, Bar-Or A, Ghezzi A, Kornberg A, Krupp L, Pohl

D, Rostasy K, Tenembaum S, Waubant E, Wassmer E. International Pediatric MS Study

Group clinical trials summit. Neurology, 2013 80:1161-68

109. Tenembaum SN, Banwell B, Pohl D, Krupp LB, Boyko A, Meinel M, Lehr L, Rocak S, Verdun

di Cantogno E, Stam Moraga M and Ghezzi A. Subcutaneous Interferon Beta-1a in Pediatric

Multiple Sclerosis: A Retrospective Study. J Child Neurol, published online 10 May 2013

110. Krupp LB, Tardieu M, Amato MP Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R,

Kornberg A, Pohl D, \Rostasy R, Tenembaum S Wassmer E and the International Pediatric

Multiple Sclerosis Study Group. lnternational Pediatric Multiple Sclerosis Study Group

criteria for pediatric multiple sclerosis and immune-mediated central nervous system

demyelinating disorders: revisions to the 2007 definitions. Multiple Sclerosis Journal,

2013;19:1261-1267

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111. Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A, Milazzo M,

Gorman M, Weinstock-Guttman B, Rodriguez M, James JA. Antibody responses to common

viruses and human leukocyte antigen DRB 1 in pediatric multiple sclerosis. Multiple

Sclerosis Journal. 2013; 19: 891-895

112. Vingara LK, Yu HJ, Wagshul ME, Serafin D, Christodoulou C, Pelczer I, Krupp LB,

Maletić-Savatić M. Metabolomic approach to human brain spectroscopy identifies

associations between clinical features and the frontal lobe metabolome in multiple

sclerosis. Neuroimage 2013; 82C:586-594

113. McElroy JP, Krupp LB, Johnson BA, McCauley JL, Qi, Z, , SJ Caillier SJ, Gourraud PA, Yu

J, Nathanson L, Belman AL, Hauser SL, Waubant E, , Hedges DJ and Oksenberg JR. Copy

number variation in pediatric multiple sclerosis Multiple Sclerosis Journal 2013; 19:1014-

1021

115. Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttman B, Yeh A,

Rodriguez M, Ness J, Gorman MP, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E,

Krupp, L. Multiple Quantitative MRI analysis in children with multiple sclerosis. BMC

Neurology 2013; 13(1):173.

116. Weisbrot D. Charvet LC, Serafin D, Krupp LB. Psychiatric diagnoses and cognitive

impairment in pediatric multiple sclerosis. Multiple Sclerosis Journal.2014; 20:588-593

117. Charvet LE, Cleary R, Vasquez K, Krupp LB for the US Network of Pediatric MS Centers.

Social cognition in pediatric multiple sclerosis. Multiple Sclerosis 2014;11:1478-1484

118. Leigh E. Charvet, PhD, Ellen H. O’Donnell,PhD, Anita Belman, MD, Tanuja Chitnis,

Jayne M. Ness, MD, Joy Parrish, PhD, Marc Patterson, MD, Moses Rodriguez, MD,

Emmanuelle Waubant, PhD, MD, Bianca Weinstock-Guttman, MD, Lauren B. Krupp, MD,

on behalf of the U.S. Network of Pediatric MS Centers. Longitudinal Evaluation of Cognitive

Functioning in Pediatric Multiple Sclerosis (MS) Report from the U.S. Pediatric Multiple

Sclerosis Network. Multiple Sclerosis Journal 2014;11:1502-1508

119. Charvet LE, Beekman R, Krupp LB. The Symbol Digit Modalities Test is a sensitive and

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specific screen for cognitive impairment in pediatric multiple sclerosis. J Neurol Sci.2014;

341: 79-84.

120. Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness

WeinstockGuttman B, Gorman M, Patterson M, Rodriguez M, Lotze T, Aaen G, Mowry EM,

Rose JW, Simmons T, Casper TC, James J, Waubant E; US Network of Pediatric Multiple

Sclerosis Centers. Protective environmental factors for neuromyelitis optica .Neurology.

2014; 83:1923-9

121. Weinfurtner K, Graves J, Ness J, Krupp L, Milazzo M, Waubant E.

Prolonged Remission in Neuromyelitis Optica Following Cessation of Rituximab

Treatment. J Child Neurol. 2014 Nov 10. [Epub ahead of print ]

122. Casper TC, Rose JW, Roalstad S, Waubant E, Aaen G, Belman A, Chitnis T,

Gorman M,L.,Krupp L, Lotze TE Ness J, Patterson M, Rodriguez M, Weinstock-Guttman B,

Browning B, Graves J, Tillema JM, Benson L, Harris Y; the US Network of Pediatric

Multiple Sclerosis Centers. The US Network of Pediatric Multiple Sclerosis Centers:

Development, Progress, and Next Steps.J Child Neurol. 2014 Sep 30. [Epub ahead of print]

123. Charvet LE, Taub E, Rosicki C, Serafin D, Krupp LB.The Montreal Cognitive Assessment

(MoCA) in Multiple Sclerosis: Relation to Clinical Features. Journal of Multiple

Sclerosis 2015 2:2.

124. Kasschau M, Sherman K, Haider L, Frontario A, Krupp LB, Datta A, Bikson M, Charvet LE.

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation in

Clinical Trials in Multiple Sclerosis (MS). Journal of Visualized Experiments. J. Vis. Exp. 2015

(106), e53542, doi:10.3791/53542

125.Nunan-Saah J, Paulraj SR, Waubant E, Krupp LB, Gomez RG.

Neuropsychological correlates of multiple sclerosis across the lifespan. Mult Scler. Mult

Scler 2015. 21:1355-1364

126. Lublin FD, Bowen JD, Huddlestone J, Kremenchutzky M, Carpenter A, Corboy JR, Krupp L,

Paulo C, Hariri RJ, Fischkoff SA. Human placenta-derived cells (PDA-001) for the treatment

of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study-

Mult Scler Relat Disord. 2014;6:696-70

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127. Kavak KS, Teter BE, Hagemeier J, Zakalik K, Weinstock-Guttman B; New York State MS

Consortium. Higher weight in adolescence and young adulthood is associated with an

earlier age at multiple sclerosis onset. Mult Scler. 2015 7:858-65

128. Wassmer E, Chitnis T, Pohl D, Amato MP, Banwell B, Ghezzi A, Hintzen RQ, Krupp LB,

Makhani N, Rostásy K, Tardieu M, Tenembaum S, Waldman A, Waubant E, Kornberg AJ.

International Pediatric MS Study Group Global Members Symposium report.

Neurology. 2016 Aug 30;87(9 Suppl 2):S110-6.

129. Charvet L, Cersosimo B, Schwarz C, Belman A, Krupp LB. Behavioral Symptoms in Pediatric

Multiple Sclerosis: Relation to Fatigue and Cognitive Impairment. J Child Neurol. 2016

Jul;31(8):1062-7.

130. Graves JS, Barcellos LF, Shao, X, Noble J, Mowry EM, Quach H, Belman A, Casper TC,

Krupp LB, Waubant E. Genetic predictors of relapse rate in pediatric MS. Multiple Sclerosis

Journal 2016; Jan 14 Mult Scler. 2016 Jan 14. pii: 1352458515624269.

131. Krupp, LB, Krupp LB, Pohl D, Ghezzi A, Boyko A, Tenembaum A, Chen L, Aycardi E, Banwell

B, on behalf of the REPLAY Study Group. Subcutaneous interferon <beta>-1a in pediatric

patients with multiple sclerosis: regional differences in clinical features, disease

management, and treatment outcomes in an international retrospective study. J Neurol

Sci. 2016 Apr 15;363:33-8.

132. Friedman JH, Beck JC, Chou KL, Clark G, Fagundes CP, Goetz CG, Herlofson K, Kluger

B, Krupp LB, Lang AE, Lou JS, Marsh L, Newbould A, Weintraub D. Fatigue in Parkinson’s

Disease: report from a multidisciplinary symposium. J Parkinsons Dis. 2016;2. pii:

15025. Epub 2016 Jan 14.

133. McDonald J, Graves J, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B,

Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Lulu S, Ness J, Harris Y, Rubin J,

Candee M, Krupp LB, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Barcellos LF,

Laraia B, Rose J, Roalstad S, Simmons T, Casper TC, Waubant E. A case-control study of

dietary salt intake in pediatric-onset multiple sclerosis. Mult Scler Relat Disord. 2016

Mar;6:87-92.

134. Charvet L, Cersosimo B, Schwarz C, Belman A, Krupp LB. Behavioral symptoms in

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pediatric Multiple Sclerosis: relation to fatigue and cognitive impairment.

J Child Neurol. 2016 Jul;31(8):1062-7.

135. Belman AL, Krupp LB, Olsen CS, Rose JW, Aaen G, Benson L, Chitnis T, Gorman M,

Graves J, Harris Y, Lotze T, Ness J, Rodriguez M,Tillema JM, Waubant E,

Weinstock-Guttman B, Casper TC; US Network of Pediatric MS Centers. Characteristics

of children and adolescents with Multiple Sclerosis. Pediatrics. 2016 Jul;138(1).

pii: e20160120. doi: 10.1542/peds.2016-0120.

136. Amato MP, Krupp LB, Charvet LE, Penner I, Till C. Pediatric multiple sclerosis:

Cognition and mood. Neurology. 2016 Aug 30;87(9 Suppl 2):S82-7. doi: 10.

137. Tardieu M, Banwell B, Wolinsky JS, Pohl D, Krupp LB. Consensus definitions for

pediatric MS and other demyelinating disorders in childhood.

Neurology. 2016 Aug 30;87(9 Suppl 2):S8-S11.

138. Krupp LB, Rintell D, Charvet LE, Milazzo M, Wassmer E. Pediatric multiple sclerosis:

Perspectives from adolescents and their families. Neurology. 2016 Aug 30;87(9 Suppl

2):S4-7. doi: 10.1212/WNL.

139. Chitnis T, Graves J, Weinstock-Guttman B, Belman A, Olsen C, Misra M, Asen G, Benson L,

Candee M, Gorman M, Greenberg B, Krupp L, Lotze T, Mar S, Ness J, Rose J, Rubin J,

Schreiner T, Tillema J, Waldman A, Rodriguez M, Casper C, Waubant E; U.S.Network of

Pediatric MS Centers. Distinct effects of obesity and puberty on risk and age at onset of

pediatric MS. Ann Clin Transl Neurol 2016 Nov 4;3(12):897-907.