Curriculum Vitae -- Bradley B. Keller,...

Curriculum Vitae -- Bradley B. Keller, MD

1 Updated: April 23, 2012

BIOGRAPHY and CONTACT INFORMATION

Bradley B. Keller, M.D. Birth Date: November 22, 1959

Birth Place: Ellwood City, PA

Citizenship: USA

Residence: 302 E. Muhammad Ali Blvd.

Louisville, KY 40202

Phone: 502-852-5809

Academic Office: Clinical Practice Office:

Cardiovascular Innovation Institute Pediatric Cardiology Associates, PSC

University of Louisville 601 South Floyd Street, Suite 602

302 East Muhammad Ali Blvd Louisville, KY 40202

Louisville, KY 40202 Clinical Office Phone: 502-585-4802

Academic Office Phone: 502-852-5809 Clinical Office Fax: 502-589-1368

Academic Office Fax: 502-852-1391 Practice Manager: Melanie Logsdon

Mobile Phone: 412-478-6463 502-585-2256

Email: [email protected] [email protected]

Administrative Assistant: Jeannine Barron 502-852-5809

[email protected]

A. Education

UNDERGRADUATE: Dates Institution and Location Degree Received Major

Sept. 1977 – May 1981 University of Pennsylvania Bachelor of Arts (1981) Biology (genetics)

Philadelphia, PA

GRADUATE: Dates Institution and Location Degree Received

Sept. 1981 – May 1985 Pennsylvania State University Doctor of Medicine (1985)

College of Medicine, Hershey, PA

POST GRADUATE: Dates Institution and Location Field of Training Program Director June 1985 – June 1988 Department of Pediatrics Pediatrics (1988) Dr. Frank Oski

The Johns Hopkins Hospital

Baltimore, MD

July 1988 – June 1991 Department of Pediatrics Pediatric Cardiology Dr. Edward B. Clark

University of Rochester School Fellowship (1991)

of Medicine, Rochester, NY

B. Academic Appointments Dates Name of Institution Rank/Title/Position

July 1988 - June 1991 University of Rochester Instructor and Fellow, Pediatrics

July 1988 - June 1992 University of Rochester Attending Pediatrician, Emergency Department

July 1991 - November 1996 University of Rochester Assistant Professor, Department of Pediatrics

October 1992 - July 1996 University of Rochester Assistant Professor, Department of Physiology

Dates Name of Institution Rank/Title/Position

May 1996 - July 1999 University of Rochester Director, Pediatric CV Disease

Specialized Center of Research

December 1996 - June 1998 University of Rochester Associate Professor, Department of Pediatrics

mailto:[email protected]





July 1998 - June 2000 University of Rochester Adjunct Associate Professor, Dept of Pediatrics

July 1998 - July 2002 University of Kentucky Jennifer Gill Associate Professor, Dept. of Pediatrics,

Chief, Division of Pediatric Cardiology

May 1999 - March 2000 University of Kentucky Medical Director, Pediatric Subspecialty Clinic

July 2001 - June 2002 University of Kentucky Associate Professor with Tenure, Dept of Pediatrics

July 2002 - June 2003 University of Kentucky Professor with Tenure, Department of Pediatrics

August 2002 – present University of Pittsburgh Professor, Department of Pediatrics (tenure)

August 2002 – June 2006 University of Pittsburgh Chief, Division of Pediatric Cardiology

August 2002 - present University of Pittsburgh Member, McGowan Institute for Regen. Medicine

August 2002 – March 2006 University of Pittsburgh Research Associate, Magee-Womens Research Instit.

March 2006 - April 2009 University of Pittsburgh Senior Investigator, Magee-Womens Research Institute

September 2003 – June 2009 University of Pittsburgh Graduate Faculty, Cell Biol. and Molecular Physiology

July 2005 – June 2006 University of Pittsburgh Director, Pediatric Card. Fellowship Training Program

July 2006 – April 2009 University of Pittsburgh Director, Pediatric Biomedical Innovative Technology

January 2007 – April 2009 University of Pittsburgh Member, Standing Committee for Tenured Faculty

Promotion and Appointment

January 2007 – April 2009 University of Pittsburgh Member, Institutional Review Board (IRB) Committee

May 2007 – present University of Pittsburgh Professor (secondary appt.), Department of

Bioengineering

June 2007 – April 2009 Children’s Hospital of Pittsburgh Member, Committee on Surgical Innovation (COSI)

July 2007 – April 2009 University of Pittsburgh Member, Technology Transfer Committee

May 2008 – present Carnegie Mellon University Adjunct Professor, Dept. of Biomedical Engineering

May 2009 - present University of Louisville Professor, Department of Pediatrics (tenure),

Division of Pediatric Cardiology

May 2009 - present University of Louisville Kosair Charities Chair in Pediatric Heart Research

May 2009 - present University of Louisville Chief, Pediatric Heart Research, Cardiovascular

Innovation Institute

July 2009 – present University of Louisville Professor (adjunct), Department of Bioengineering

June 2010 – present University of Louisville Vice Chair for Research, Department of Pediatrics

July 2010 – present University of Louisville Professor (joint), Department of Pharmacology and

Toxicology

C. Other positions and Employment including Military Service. None.

D. Board Certification and Licensure

MEDICAL LICENSURE: Licensing Board/State License Number Year National Board of Medical Examiners 308742 1986

Maryland D35795 1987

New York 174593 1988

Kentucky 34628 1999, re-activated 2009

Pennsylvania MD420075 2002

Federal Drug Enforcement Agency on request 1992, 2002

China and Tibet Autonomous Region temporary 2005, 2007, 2009, 2010

SPECIALTY CERTIFICATION: Certifying Board Certificate Number Year

Pediatrics 211796 1989, 2001

Pediatric Cardiology 211796 1991, 2001, 2007

Professional licensure and hospital privileges have never been revoked, suspended, or voluntarily reduced.



E. Professional Society Boards and Activities Organization Years

Rochester Community I.P.A., Inc., Cardiology Subcommittee 1996 - 1998

American Heart Association New York State Affiliate 1993 - 1998

Research Committee, Vice Chair 1994 - 1996

Chair, Grant Peer Review II 1995 - 1997

Executive Committee 1996 - 1998

American Heart Association, Genesee Board of Directors 1994 - 1998

Nominating Committee 1996 - 1998

Executive Board, Secretary 1996 - 1998

American Heart Association Mid-Atlantic Region 2003 - 2007

Research Peer Review, Cardiovascular Development and Basic Science

Co-chair, CV Development and Basic Science Review Panel 2005 - 2007

American Heart Association, National

Basic Science Research Committee Member 2009- present

Research Outcomes Taskforce 2010 -present

F. Honors and Awards Title of Award Year

Rotary International Foundation Educational Award 1979 - 1980

Magna cum laude, University of Pennsylvania 1981

Phi Beta Kappa, University of Pennsylvania 1981

University of Miami Medical Student Research Forum, First Place, Poster 1985

Fellow's Medical Student Teaching Award 1988

University of Rochester Class of 1988

World Forum Research Finalist 1993

1993 World Congress of Pediatric Cardiology and Cardiac Surgery

Chairman’s Award for Pediatric Research 2001

Department of Pediatrics, Univ. of Kentucky

Patient Satisfaction Award: Outstanding Achievement in Patient Care

Children’s Hospital of Pittsburgh top 25 physicians 2004, 2005

Children’s Hospital of Pittsburgh top 10 physicians 2006

National Patient Satisfaction Award 2007, 2008

Kosair Charities Chair in Pediatric Heart Research 2009

RESEARCH FELLOWSHIP TRAINING AWARDS NIH NHLBI NRSA

Post-Doctoral Fellowship #F32-HL07824. 07/01/1998 - 06/31/1990

Ventricular Mechanics in the Developing Chick Heart.

(E.B. Clark, sponsor, K. Sagawa, advisor).

UNIVERSITY OF ROCHESTER 07/01/1989 - 06/31/1990

Bradford Pediatric Fellow

NIH NHLBI PSA

Physician-Scientist Training Award #K11-HL02498. 07/01/1990 - 06/31/1995

Ventricular Mechanics in the Chick Embryo.



G. Committee Assignments and Administrative Services

DEPARTMENT, HOSPITAL, AND UNIVERSITY COMMITTEES

UNIVERSITY OF ROCHESTER

Strong Memorial Hospital Medical Records Committee 07/01/93 - 06/31/98

Policy Revision Subcommittee 07/01/96 - 06/31/98

Children's Hospital at Strong Faculty Liaison, Fundraising 07/01/94 - 06/31/98

UNIVERSITY OF KENTUCKY

Executive Committee Department of Pediatrics 07/01/98 - 07/31/02

Pediatric Clinic Management Group Department of Pediatrics 07/01/99 - 06/31/00

Children’s Services Committee Children’s Hospital 07/01/98 - 06/31/00

Business Process Improvement “A” Chandler Medical Center 07/01/99 - 07/31/02

Steering Committee Gill Heart Institute 07/01/98 - 06/31/99

Faculty Recruitment Committee Department of Biochemistry 07/01/98 - 02/01/99

Research Self-Study Committee College of Medicine 07/01/01 - 12/01/01

CHILDRENS HOSPITAL OF PITTSBURGH Division Chiefs Committee Department of Pediatrics 08/01/02 - 06/30/06

New Research Campus Design and Children's Hospital of Pittsburgh 10/01/02 - 06/30/06

Programming Committees

New CHP Hospital Design

Director, Summer Student Research Program Children's Hospital of Pittsburgh 02/01/03 - 01/31/08

Faculty Incentive Plan Committee Department of Pediatrics 04/01/03 - 06/31/04

Medical Executive Committee Children's Hospital of Pittsburgh 07/01/03 - 07/01/06

Credentialing Committee Children’s Hospital of Pittsburgh 08/01/05 - 04/30/09

Innovative Surgical Technology Committee Children’s Hospital of Pittsburgh 06/01/07 - 04/30/09

Medical Staff Bylaws Committee Children’s Hospital of Pittsburgh 12/13/07 - 04/30/09

UNIVERSITY OF PITTSBURGH Human Investigational Review Board (appointed) 01/01/07 - 04/30/09

Standing Committee for Tenured Faculty Promotion and Appointment (elected) 01/01/07 - 04/30/09

Technology Transfer Committee (appointed) 07/01/07 - 04/30/09

UNIVERSITY OF LOUISVILLE and the KOSAIR CHILDREN’S HOSPITAL

Cardiovascular Innovation Institute, Division Head Management Committee 05/01/09 - present

Dept. of Pediatrics Committee for Tenured Faculty Promotion, Appointment, and Tenure 05/01/09 - present

Dept. of Pediatrics, KCHRI Director Search Committee 07/01/09 - present

Dept. of Pediatrics, Regionalization Committee 07/01/10 - present

Dept. of Pediatrics, Operational Leadership Committee 07/10/10 - present

Dept. of Pediatrics, New Ambulatory Building Planning Committee 09/01/10 - present

Univ. of Louisville, Faculty Senate, School of Medicine Representative 09/01/09 - present

Univ. of Louisville, School of Dentistry, 5 year Chair Review Committee 01/10/10 - 06/30/10

Univ. of Louisville, Executive Vice President for Health Affairs Search Committee 07/01/10 - 07/01/11

Kosair Children’s Hospital, Outreach Committee 09/01/10 - present

Kosair Children’s Hospital , Medical Executive Committee 01/05/11- present

Kosair Children’s Hospital, Academic Excellence Committee Co-Chair 04/01/11 - present

Kosair Children’s Hospital, Physician Workforce Committee 04/01/11 - present



H. Journal Editorial Boards, Advisory Councils, Peer Reviewer of Manuscripts PARTICIPATION IN PEER REVIEW OF SCIENTIFIC PUBLICATIONS

American J. Physiology Anatomical Record Archives of Peds and Adol Med Basic Research Cardiology

Birth Defects Research Cardiovascular Research Circulation Research Current Opinion in Cardiol.

Developmental Dynamics Diabetes Institute for LabAnimal Res (NAS) J Biomech Engineering

J Clinical Investigation J Experimental Biology J Mol Cell Cardiology Pediatric Cardiology

Pediatrics International Pediatric Research Pediatric Transplantation Physiological Genomics

Teratology Tissue Engineering Trends in Pharmacol Science J Cardiac Failure

PARTICIPATION IN STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW Panel participant Special Emphasis Panel on Research Priorities for Special Centers of Research in Pediatric

Cardiovascular Diseases, Philadelphia, 1996.

Panel participant NIH Special Emphasis Panel to develop priorities for the NHLBI SCOR awards in Pediatric

Cardiovascular Diseases, Bethesda, 1997.

Panel participant NIH Special Emphasis Panel to review grant applications for Specialized Centers of Research

in Pediatric Cardiovascular Diseases, Bethesda, 1998.

Panel participant NIH Special Emphasis Panel to review grant applications for heart failure RFA HL-97-012.

Panel participant NIH Special Emphasis Panel on Saturation Mutagenesis and Murine Cardiovascular

Phenotyping. Denver, CO, November 1998.

Panel participant NIH Special Emphasis Panel to review Pediatric SCOR applications, NHLBI, January 2001.

Panel participant NIH NHLBI CV-A study section, Bethesda, MD, February 2001.

Panel participant NIH Special Emphasis Panel on Bioengineering Research Partnerships Bethesda, MD, April,

2001.

Panel participant American Heart Association Mid-Atlantic Study Section 6, grant review member, Bethesda,

MD April, 2004.

Session co-chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD,

March 2005

Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda,

2005

Session chairman American Heart Association Mid-Atlantic Study Section 6 grant review, Bethesda, MD,

April 2006, April 2007

Panel participant NIH Special Emphasis Panel for PO1 applications on Novel Cardiovascular Genes, Bethesda,

2006

Panel participant NIH Myocardial Ischemia and Metabolism Study Section – Ad Hoc Reviewer, Bethesda,

June 2006

Panel participant NIH Special Emphasis Panel Review: Institutional NHLBI Training Programs, Bethesda,

Nov. 2006 Baltimore, Nov. 2007, Baltimore June & Dec 2008, Standing Study Section

Member (July 1, 2009)

Panel participant NIH NHLBI IRG CDD Study Section Ad Hoc Reviewer, Bethesda, MD June & November

2007 Standing Study Section Member effective July 1, 2008 through June 2012



STATE, NATIONAL, AND INTERNATIONAL RESEARCH PROPOSAL PEER REVIEW (continued) Panel chair NIH Special Emphasis Panel for cardiac stem cell R01 applications, March 2008, October

2008

PARTICIPATION IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Panel participant Committee on New and Emerging Models in Biomedical and Behavioral Research, National

Research Council, Washington, 1997.

Panel participant NIH Working Group on “The role of cholesterol and lipids in embryonic development and

congenital disease”, Nashville, 1998.

Panel participant Hormonal Regulation of the Growth and Function of the Neonatal Heart. 73rd Scientific

Sessions, American Heart Association, New Orleans, November, 2000.

Panel participant NIH Working Group on “Future Directions for Research Funding in Cardiac Development”,

St. Louis, June, 2000.

ORGANIZATION ROLE IN REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS Session co-chairman The World Congress on Medical Physics and Biomedical Engineering, Kyoto, JAPAN, 1991.

Session co-chairman American Physiology Society sponsored Scientific Symposium: Regulation, integration,

adaption: a species approach, San Diego,1994.

Session moderator NHLBI Weinstein Cardiac Morphogenesis and Development Meeting: Philadelphia, PA,

1996.

Session co-chairman 2nd World Congress, Pediatric Cardiology and Cardiac Surgery, Honolulu, Hawaii, 1997.

Session chairman Developmental changes in cardiac function. Muroran Institute of Technology, Japan , 1998.

Session moderator Cardiovascular Physiology and Engineering. Weinstein Cardiovascular Development

Conference, Vanderbilt University, Nashville, 1998

Session co-chairman Selection of Animal Models. 71st Scientific Sessions, American Heart Association, Dallas,

November, 1998.

Program organizer “Noonan Congenital Cardiovascular Symposium”, 10/8/99, Lexington, KY.

11 speakers, 80 participants.

Session co-chairman Featured Research: Mouse Models of Cardiac Dysfunction.72nd Scientific Sessions,

American Heart Association, Atlanta, November, 1999.

Steering committee “International Symposium on the Developing Heart”, 5/18-20/2000, Prague, Czech Republic.

40 speakers, 300 participants.

Session chairman Function and Metabolism of the Developing Heart. International Symposium on the

Developing Heart. Czech Academy of Sciences, Prague, May 2000.

Session moderator Roundtable in Comparative Developmental Physiology, Sponsored by NSF Inn on the

River, Glen Rose, TX, June 2002.

Session moderator Mechanics in Cardiac Development. 9th Weinstein Cardiovascular Development

Conference, Boston, MA, May 2003

Steering committee “2004 McGowan Institute for Regenerative Medicine Retreat” 2/23-24/2004,

Nemacolin Resort, 10 speakers, 150 participants.



Steering committee “2005 McGowan Institute for Regenerative Medicine Retreat” 3/6-7/2005

Nemacolin Resort, 12 speakers, 170 participants.

Program co-organizer “First Annual Symposium on Advances in Congenital Cardiovascular Care” 10/15/05

Renaissance Hotel, Pittsburgh, PA, 12 speakers, 75 participants

Session chairman Biomechanics of Cardiovascular Development. 5th World Congress of Biomechanics.

Munich, Germany, July 2006

Program Committee “Patient and Family Centered Care Workshop Series: The Innovators Conference”, 11/7/07,

Pittsburgh, PA

Session co-chairman Diastology in Congenital Heart Disease. 82nd Scientific Sessions, American Heart

Association, Orlando, November, 2009.

ACADEMIC ADVISORY ACTIVITIES May 2009 – present State of Nebraska Founding committee member, Nebraska Stem Cell

Advisory Committee “Stem Cell Research Act, LB606”

July 2009 – present University of North Texas Member, External Advisory Board, Development,

Physiology, and Genetics Academic Cluster

January 2010 –July 2010 University of Nebraska Medical Center Expanding Pediatric Cardiovascular Research

Children’s Medical Center

COMMUNITY FOUNDATIONS Medical Research Advisory Committee The Pittsburgh Foundation 04/01/03 - 04/30/09

Proposal Reviewer Pittsburgh Life Sciences Greenhouse 02/02/05 - 04/30/09

Proposal Reviewer Pittsburgh Technology Council 02/02/05 - 04/30/09

INTERNATIONAL COMMUNITY SERVICE Medical Director Touching Hearts Program in Tibet 07/01/05 – 06/01/10

This program screened school children in the Tibet Autonomous Region, PRC for congenital heart disease and then provided

cardiac catheterization, interventional closure of ASDs and PDAs in Lhasa, Tibet Autonomous Region, PRC and surgical

referral to Pediatric Heart Centers in Beijing and ChengDu, PRC. Funded by SEAPC, Oakmont, PA, via community

donations. More than 21,000 screened and 250 children successfully treated. Program operations are suspended pending

contract renewal.

I. Academic Society Memberships

Organization Year

American Academy of Pediatrics, Fellow 1992 - present

Society for Pediatric Research, Member 1994 – present

American Heart Association, National 1990 - present

Cardiovascular Disease in the Young

Basic Science 1992 – present

New York Academy of Science, Member 1996 - present

Kentucky Medical Association 1999 - present

American Physiologic Society, Member 1999 - present

American Association for the Advancement of Science, Member 1999 - present

National Marfan Society 1999 - present

International Society for Heart Research 2000 - present

International Society for Adult Congenital Heart Disease 2000 - present

Society for Southern Pediatric Research 2000 - present

Heart Failure Society of America 2000 - present

American Pediatric Society 2004 - present

American Telemedicine Association 2008 – present



J. Mentoring DOCTORAL THESIS COMMITTEES

Sandra Stekelenburg-de Vos 7/01 to 6/05 Hemodynamics and heart function in the venous

clipped chick embryo. Dept. of Ob/Gyn. Erasmus

Univ, the Netherlands

Thomas R. Payne 7/02 to 6/06 Differential myocardial infarct repair with muscle

derived stem cells. Dept. of Bioengineering.

University of Pittsburgh

Arielle Drummond 7/05 to 12/08 Simulation of the optimal insertion for a pediatric VAD

Dept. of Bioengineering. Carnegie Mellon University

Hsun-Hsien Chang 3/06 to 9/07 Cardiovascular magnetic resonance imaging of

paramagnetic particles to detect cardiac rejection.

Carnegie Mellon Univ.

Ti Soon Park 6/06 to 12/08 Origin and fate of human hemangioblast stem cells.

Dept. of Cell Biology and Physiology. Univ. of

Pittsburgh

Lorenzo Soletti 6/06 to 11/08 Development of a Stem Cell-Based Tissue Engineered

Vascular Graft. Dept. of Bioengineering, University of

Pittsburgh

Lauren Drowley 6/07 to 6/09 Myocardial repair using muscle derived stem cells.

Depts.of Orthopedics and Bioengineering. University

of Pittsburgh

John Stella 05/08 to 9/11 Tissue engineering approaches for pulmonary valve

surrogates. Dept. of Bioengineering, University of

Pittsburgh

Yajuan Wang 05/08 to 12/11 Decision support for ventricular mechanical assist device

. Dept. of Bioengineering. Carnegie Mellon University

Hiren Trada 07/10 to present Development of porous multiple electrode arrays

(P-MEA) to quantify and accelerate engineered tissue

maturation. Dept. of Electrical and Computer

Engineering. University of Louisville

SCHOLARLY PROJECT AND RESEARCH MENTOR COMMITTEES

Adeboyega Abdulkadir 7/06 to 6/08 Relationship between Fetal Rat Hemodynamics,

Periventricular Leukomalacia, and Chorioamnionitis

Diego Mougillansky 7/06 to 4/09 Novel Contrast Agent Approaches to Characterize

Injured Myocardium.

Evonne Krushansky 7/07 to 4/09 Wireless Detection of Abnormal Cardiac Electrical

Activity (PELEX-C)

Stephanie Downs 10/07 to 5/ 10 Improved Detection of Rural Congenital Heart Disease:

The Touching Hearts in Tibet Project

Alison Keskey 01/01/11 – present Application of Home Telemonitoring to High-Risk

Infants with Congenital Heart Disease (DIR program)



Junior Faculty

K. Tobita, MD 7/02 to 5/09 Biomechanics of Embryonic CV Systems

Currently: Assistant Professor, Dept. of Dev. Biol.

University of Pittsburgh, Pittsburgh, PA

C. Ralphe, M.D. 6/04 to 11/07 Maturation of Cardiomyocyte Mitochondrial Function

Currently: Assistant Professor, Dept. of Pediatrics,

Division Chief, Pediatric Cardiology, University of

Wisconsin, Madison, WS

I. Libman, MD, PhD 7/04 to 5/09 Relationship Between Type I Diabetes Mellitus,

Obesity, and Cardiovascular Risk Factors



T. Yanowitz, M.D. 9/04 to 11/07 Relationship between Fetal Rat Hemodynamics,

Periventricular Leukomalacia, and Chorioamnionitis



Post-Doctoral Residents and Fellows F. Heller, M.D. 1/92 to 3/92 Ventricular Function During Altered Contractile State


University of Connecticut, Hartford, CT

J. Murillo-Gonzalez, M.D .9/92 to 11/92 Morphogenesis during Cardiac Looping, Universidad

Complutense, Madrid, SPAIN

Currently: Associate Professor, Dept. of Anat. and Emb,

Universidad Complutense, Madrid, SPAIN

P. Bowers, M.D. 12/92 to 6/95 Ventricular/vascular Coupling During Alterations in the

Nitric Oxide Pathway

Currently: Medical Director, Blue Cross/Blue Shield of

Connecticut, Hartford, CT

M. Yoshigi, M.D. 10/94 to 9/97 Arterial Hemodynamics in the Embryonic Circulation

(Dept. of Ped Card, Tokyo Women's Medical Col)

Currently: Assistant Professor, Dept of Pediatrics,

University of Utah, Salt Lake City, UT

M. Broekhuizen, M.D. 5/95 to 5/97 Ventricular Function Following Retinoic Acid

Treatment in the Stage 21 Chick Embryo. (Univ. Leiden,

the Netherlands)

Currently: Clinical Practice, Leiden, the Netherlands

S. Furukawa, M.D. 7/96 to 6/98 Murine Maternal/Embryonic Coupling During

Cardiovascular Development. (Medical College,

Miyazaki City, Japan)

Currently: Assistant Professor, Department of

Obstetrics and Gynecology, Miyazaki City, Japan

K. Tobita, M.D. 7/97 to 7/02 Embryonic Ventricular Mechanics Following Cardiac

Septation (Dept. of Ped Card, TWMC, Tokyo)

Currently: Assistant Professor, Dept. of Dev. Biol.,

University of Pittsburgh, Pittsburgh PA



Post-Doctoral Residents and Fellows (continued) E. Schroder, Ph.D. 12/97 to 8/02 Myocardial Mechanics During Cardiovascular

Development.

Currently: Assistant Professor, Dept. of Physiology,

University of Kentucky, Lexington, KY

R. Akiyama, Ph.D. 4/99 to 4/00 Numerical Analysis of Embryonic Blood Flow.

Currently: Research Assistant Professor, Dept. of

Engineering, Mururan University, Mururan, Japan

L. Jeffries, M.D. 6/99 to 7/01 Outcome Assessment in Rural Adult Congenital Heart

Disease.

Currently: Assistant Professor, Dept. of Peds., Baylor

University, Houston, TX

S. Sharma, M.D. 1/03 to 7/05 Regulation of Cardiovascular Structure and Function by

Oxygen Tension in Chick and Mouse Embryos

Currently: Pediatric Cardiology Practice, University of

Tennessee, Knoxville, TN

J. Lucitti, Ph.D. 4/03 to 8/05 Physiology and Biomechanics of the Developing

Vasculature and Ventriculo-Vascular Interactions

Currently: Research Scientist, UNC, Chapel Hill, NC

N. Momoi, M.D. 4/04 to 4/06 Rodent Models of Cardiovascular Maternal-Fetal

Coupling

Currently: Associate Professor, Dept. of Peds.,

Fukushima Medical University, Japan

M. Saaloukeh, M.D. 10/04 to 6/06 Intrauterine Effects of Maternal Caffeine Exposure on

Murine Embryonic Growth and Hemodynamics

Currently: Neonatology clinical practice

M. Manole M.D. 10 /04 to 6/06 Effect of Prerminal Gasping During Anoxic Arrest on

Cardiac Function in Immature Rats

Currently: Assistant Professor, Dept. of Emergency

Med., University of Pittsburgh, Pittsburgh, PA

E. Krushansky, M.D. 9/07 to 5/09 Wireless Detection of Abnormal Cardiac Electrical

Activity (PELEX-C)

Currently: Pediatric Cardiology Fellow, Dept. of Peds.,

Children’s Hospital of Pittsburgh, Pittsburgh, PA

K. Cross, MD 2/10 to 6/11 Comparative Effectiveness of Ultrasound-Guided

Nerve Block Versus Conscious Sedation for Pediatric

Orthopedic Injury Management

Currently: Pediatric Emergency Medicine Faculty

Dept. of Peds., University of Louisville.

R. Salimi, MD 12/10 to present Development of a Small Animal Model to Investigate

Capillary Leak via Reconstituted Microvascular

Networks

M. Peek, MD 07/11 to present Development and Validation of Home Telemedicine

Supported Anticoagulation Management



Post-Doctoral Residents and Fellows (continued) L Krishnan, PhD 07/11 to present Regenerative Potential of Umbilical Cord Derived

Mesenchymal Stem Cells in Pediatric Cardiovascular

Repair

Ramon Ymalay 07/11 to present VEV02100 High Resolution Imaging in Neonates

A. Le Blanc, PhD 08/11 to present Age-Related Differences in Stromal Vascular Fraction-

Assisted Coronary Microvascular Repair



Pre-Doctoral Students

D. Dalecki 2/89 to 5/91 Cardiac Effects of Lithotripsy and Pulsed Ultrasound

Currently: Associate Professor, Dept. of Biomed. Eng.,

University of Rochester, Rochester, NY

K. Campbell 7/90 to 9/90 Atrial Function in the Stage 16 to 24 Chick.

7/91 to 9/91 Donald Shapiro Medical Student Research Award

U of R Medical Student Research Fellowship

V. Fruci 6/90 to 9/90 Epicardial Ventricular Strains in the Stage 18 Chick

Embryo

N. Shafer 7/91 to 9/91 Morphometry of the Vitelline Arterial Tree.

7/92 to 9/92 Donald Shapiro Medical Student Research Award

U of R Medical Student Research Fellowship

D. Smith 9/91 to 12/91 Computer Image Reconstruction of the Vitelline Arterial

Tree

C. Berno 10/91 to 6/92 Ventricular Epicardial Strain Analysis in the Stage 14 to

24 Chick Embryo.

H. Sun 11/91 to 4/95 Epicardial Strain Analysis During Normal Growth and

Following Heart Rate Alterations.

J. Cartmell 7/92 to 6/93 Epicardial Strain Analysis During Alterations in Heart

Rate in the Stage 21 Chick.

J. Racy 7/92 to 9/92 Ventricular/Vascular Coupling in Response to

Isoproterenol and Supplemental Preload.

K. O'Gara 7/92 to 9/92 Embryonic Ventricular Passive Length-Tension

Relations in the Excised Embryonic Heart.

7/93 to 9/93 Ventricular/Vascular Coupling and EDRF mimetics.

C. Casillas 7/92 to 6/93 Heart Rate Reserve During Primary Cardiovascular

Morphogenesis. AHA Funded Student Fellowship

M. Preston 9/92 to 12/92 Morphometry of the Stage 9 to 13 Embryonic Heart.

N. Yip 7/93 to 9/93 Embryonic Ventricular Pressure-Volume Relations

During Changes in Heart Rate and Loading Conditions.

A. Chamis 7/93 to 9/93 3D Epicardial Strain Analysis of the Embryonic Heart.

7/94 to 9/94

Hui Li 7/93 to 5/94 Three-Dimensional Solid Geometric Modeling of the

Embryonic Heart During Cardiac Looping.

Y. Takagi 9/94 to 6/96 Accuracy Analysis of Three-Dimensional Epicardial

Strains

B. Koomer 1/95 to 6/95 Comparison of Video and Confocal Microscopic

Estimates of Embryonic Ventricular Volume.



Pre-Doctoral Students (continued)

J. Ettel 9/95 to 9/96 Arterial Impedance During Alterations in Cycle Length.

Epicardial Ventricular Strains Following Conotruncal

Banding.

N. Ursem 7/95 to 6/99 Quantification of Human Embryonic Blood Velocity

Profiles in Normal and High-Risk Pregnancies.

(Erasmus University, Rotterdam, the Netherlands)

K. Babbitt 7/95 to 7/97 Capacitive Nanosensors for Pressure Measurements in

the Embryonic Cardiovascular System. (RIT)

B. Zong 9/95 to 6/96 Electronic Signal Conditioning of Capacitive and

Piezoelectric Nanosensors for the Embryonic

Cardiovascular System. (RIT)

E. Schenck 9/95 to 6/96 Implantable Piezoelectric Telemetry Nanosensors for the

Embryonic Cardiovascular System. (RIT)

K. Mangold 6/96 to 8/96 Fetal Diagnosis and Therapy of Trisomy 21 With and

Without Congenital Heart Disease.

G. Neri 9/96 to 10/97 Microelectronic Design and Fabrication for Biological

Material Testing. (RIT)

E. Gilbert 6/97 to 8/97 Regional Myocardial Epicardial Strains Following Left-

Atrial Ligation in the Chick Embryo.

Currently: Pediatric Medical Practice, Philadelphia, PA

J. Tabor 6/01 to 8/01 Effect of Maternal Hypoxia on Murine Embryonic Heart

Function.

J. Nonemaker 5/03 to 8/03 Impact of Mechanical Strain of Myofiber Alignment on

Embryonic Cardiomyocytes

Currently: Clinical Research Specialist, Hartford, CT

C. Nordman 5/03 to 8/03 Relationship Between Hypoxia and Embryonic Chick

Cardiovascular Function

Currently: Chief Radiology Resident, University of

Pittsburgh PGY4

R. Barnett 6/04 to 8/04 Regulation of Vascular Material Properties by Altered

Biomechanical Load

E. Chay 6/04 to 8/04 Contribution of Pacing Stimulation to Cardiomyocyte

Maturation in Early Embryonic Engineered Cardiac

Tissue

M. Choi 9/04 to 8/05 Multimedia Presentation of Cardiovascular Research

A. Drummond 7/05 to 11/08 Simulation of the optimal insertion for a pediatric VAD

“2008 African-American Bioengineering Student of the

Year” Currently: Research Scientist, Circulite



Pre-Doctoral Students (continued)

Kelly Clause 7/06 to 5/10 Biomechanics of Engineered Embryonic Cardiac

Tissues (funded by NIH T32 to S. Shroff)

Currently: Doctoral Student, Dept. of BioEng,


Katie Thompson, Marita Mann, Wendy Kho 1/07 to 6/07 CMU Senior Biomechanics Design Project: Pulsatile

Alyssa Haney, Daqian Wu Phantom for Vascular Access Training CMU

Daniel Bernier, Huiyi Li, 1/07 to 6/07 CMU Senior Biomechanics Design Project: Implantable

Rajit Patel, Sid Viswanathan Pediatric Cardiovascular Biosensor CMU

Lauren A. Paladino 6/07 to 8/07 Heart Rate, Oxygen Saturation, and Blood Pressure

Response to Exercise in Children With Congenital Heart

Disease at High Altitude in the Tibet, PRC

Yajuan Wang 9/07 to 10/08 Vascular Imaging and Flow Modeling During

Cardiovascular Cardiovascular Morphogenesis

10/08 – present Decision Support Applied to Human Heart Failure

Currently: Doctoral Student, Carnegie Mellon

University, Pittsburgh, PA

Stephanie Downs 10/07 to 2/10 Improved Detection of Rural Congenital Heart Disease:

The Touching Hearts in Tibet Project

Currently: Surgical Resident, University of Pittsburgh

School of Medicine, Pittsburgh, PA

Jennifer Stevens 06/08 to 10/08 Wireless Detection of Abnormal Cardiac Electrical

Activity (PELEX-C)

Currently: Medical Student, University of Pittsburgh

School of Medicine, Pittsburgh, PA

Onur Dur 09/07 – 07/10 Computational Fluid Dynamics and Numerical

Modeling of Embryonic, Fetal, and Pediatric Blood

Flow Relevant to Congenital Heart Disease.

Currently: Staff Engineer, Thoratec, Inc.

William J Kowalski 09/09 – present Embryonic aortic arch growth and remodeling

investigated via computational fluid dynamics.

Currently: Doctoral Student, Carnegie Mellon

University, Pittsburgh, PA

Dan Kmetz 06/10 – 08/10 3D Confocal Image Analysis of Composite Engineered

Tissues Composed of Embryonic Cardiac Cells and

Microvascular Fragments

Currently: Medical Student, University of Louisville

Alison Keskey 01/01/11 – present Application of Home Telemonitoring to High-Risk

Infants with Congenital Heart Disease



MEDICAL STUDENT, RESIDENT, and FELLOW EDUCATION

General Pediatric Cardiology Teaching Rounds: Medical Students, Residents, and Fellows.

Strong Memorial Hospital, Rochester, NY (avg. 2 hours per week) 1991 - 1998

University of Kentucky Children’s Hospital, Lexington, KY (avg. 2 hours per week) 1998 - 2002

Children’s Hospital of Pittsburgh, Pittsburgh, PA (avg. 2 hours per week) 2002 – 2009

Kosair Children’s Hospital, Louisville, KY (avg. 2 hrs per week) 2009 - present

Pediatric Resident Noon Conferences: “General Pediatric Cardiology Topics” (2 course hours per year) CHP 2002 - 2009

“Challenges and Opportunities: Choosing the Physician-Scientist Career Path”. Exploring Academic

and Subspecialty Careers Symposium, Ped Residents, UofL, (2 hrs/yr) 2010 - present.

Neonatology Seminar Series: Cardiovascular Development and Diseases, CHP (2 hrs/yr) 2003 - 2006

Medical School Lectures: “Genetics of Cardiovascular Disease: from Embryo to Adult” Univ. Pitt. (4 hrs/yr) 2002 - 2007

Molecular Regulation of Cardiovascular Development, Myocardial Hyperplasia and Hypertrophy.

MSCMP 2730: Mol. Mechanisms of Tissue Growth and Adaptation. Univ. Pitt. (2 hrs/yr) 2006-2007

“Origins of CHD” Department of Pediatrics – MSIII Lecture. UofL. (1 hr/yr) 2009 - present

“Challenges and New Frontiers in Pediatric Cardiology. In: “Bench to Bedside: Introduction to

Clinical and Translational Research Lecture Series”.MSII Lecture - Clinical Translational Science

Institute, UofL (1.5 hr/yr) 2010 - present

Bioengineering Lectures: “Insights from Embryos: How to Build and Mend the Heart.” Univ. of Pittsburgh. BioE 3600: Forces

That Shape Organogenesis (2 hours / yr) 2006 - 2008

“eDesign for Cardiovascular Device Applications.” Carnegie Mellon University. (1 hrs / yr) 2006-09

“Surgery for Engineers: Congenital Heart Disease.” Carnegie Mellon University. (2 hrs / yr) 2006-09

Adult Cardiology Fellow Lectures: “Origins of CHD” Louisville, KY, (1.5 hrs/yr) 2009 – present

School of Public Health and Information Sciences Lectures: “Challenges and New Frontiers in Pediatric Cardiology”.

Pre-doctoral Students, Epidemiology and Public Health. (1.5 hr/yr) 2010 - present

Research Mentorship listed under trainees and training research funding.



K. Abstracts and Presentations (partial listing)

1. Keller BB, Hu N, Zahka KG and Clark EB. Ventricular Pressure-Area Loops in the Stage 21 Chick Embryo.

Circulation 1987;76(4):552.

2. Keller BB, Hu N, and Clark EB. Correlation of ventricular measurements with mass and function in the stage 12 to 24

chick embryo. Ped Res 1989;25:II-26A.

3. Hu N, Keller BB, and Clark EB. Relationship of cycle length, diastolic filling and ventricular performance in the stage

21 chick. Ped Res 1989;25:II-25A.

4. Hu N, Connuck D, Keller BB, and Clark EB. Diastolic ventricular function in stage 1 to 27 chick. Ped Res

1989;25(4):II-25A.

5. Keller BB, Hu N, Serrino PJ, and Clark EB. Pressure-area loop characteristics in the stage 18, 21, and 24 chick embryo.

Circulation 1989;80(4):II-165.

6. Hu N, Connuck D, Keller BB, and Clark EB. Passive and active diastolic ventricular function in stage 12 to 27 chick

embryo. Circulation 1989;80(4):II-469.

7. Keller BB, Hu N, and Clark EB. Ventricular pressure-area loop characteristics during cardiac development in the chick

embryo. In Abstracts of the First World Congress of Biomechanics. UCSD, San Diego, 1990;I:151.

8. Taber LA, Keller BB, and Clark EB. Experimental and theoretical strains in the developing chick heart. In Abstracts of

the First World Congress of Biomechanics. UCSD, San Diego, 1990;II:234.

9. Keller BB, Hu N, and Clark EB. Ventricular filling and ejection characteristics after conotruncal banding in the chick

embryo. Circulation 1990;82(4)III-187.

10. Hu N, Keller BB, and Clark EB. Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27

chick embryo. Circulation 1990;82(4)III-491.

11. Hu N, Keller BB, Taber LA, and Clark EB. Diastolic wall modulus and ventricular stiffness in the stage 16 to 27 chick

embryo. Circulation 1990;82(4)III-605.

12. Keller BB, Hu N, and Clark EB. Embryonic ventricular mechanics during early cardiac development resembles mature

pressure-volume relations. (the World Congress on Medical Physics and Biomedical Engineering, July 1991, Kyoto,

JAPAN)

13. Keller BB, Hu N, and Clark EB. Cardiac mechanics in the developing heart during normal and accelerated ventricular

growth. Ped Res 1991;29:20A

14. Campbell KA, Keller BB, Hu N, and Clark EB. Analysis of dynamic atrial dimension and function during early cardiac

development in the chick embryo. Ped Res 1991;29:15A.

15. Hu N, Keller BB, and Clark EB. The effect of bradycardia on systolic and diastolic time intervals in the stage 16 to 27

chick embryo. Ped Res 1991;29:19A.

16. Keller BB, Tinney JP, Hu N, and Clark EB. Ventricular end-diastolic and end-systolic relations in the embryonic chick

heart. Circulation 1991;84(4)II-188.

17. Taber LA, Yang M, Keller BB, and Clark EB. A poroelastic model for the trabeculated embryonic heart. Adv. Bioeng

(presented at 1991 ASME winter annual meeting).



18. Keller BB, Tinney JP, Hu N, and Clark EB. Embryonic ventricular pressure-volume mechanics. Ped Res 1992;31:235A.

19. Hu N, Taber LA, Keller BB, and Clark EB. Maintenance of ventricular relaxation rate in the growth accelerated embryo

heart in stage 21 to 29 chick. Ped Res 1992;31:19A.

20. Shafer NL, Smith DS, Babineau HP, Keller BB and Clark EB. Vitelline arterial dimensions during primary

cardiovascular development. Ped Res 1992;31:23A.

21. Keller BB, Tinney JP, Hu N. Arterial elastance in the stage 16 to 21 chick embryo. Circulation 1992;86(4)I-205.

22. Hu N, Keller BB, Clark EB. Effect of chronic verapamil treatment on ventricular relaxation rate in stage 21 to 29 chick

embryo. Circulation 1992;86(4)I-843.

23. Casillas CB, Tinney JP, Clark EB, Keller BB. Heart rate reserve during cardiovascular morphogenesis. (presented at the

Annual Conference of the Society for the Advancement of Chicanos and Native Americans in Science, Albuquerque,

New Mexico)

24. Cartmell J, Taber LA, and Keller BB. Epicardial ventricular strains during tachycardia in the stage 21 chick embryo. J.

Univ Rochester Medical Center 1993;4:26.

25. Taber LA, Lin IE, and Keller. Growth and deformation during cardiac looping: Observations and hypotheses.

proceedings of the 1993 ASME Bioengineering Conference, 1993;24:111-114.

26. Taber LA, Hu N, Murillo-Gonzales J, Clark EB, and Keller BB. Residual strain in the embryonic chick heart.

proceedings of the 1993 ASME Bioengineering Conference, 1993;24:115-118.

27. Keller BB, Tinney JP, and Hu N. Ventricular/vascular coupling in the stage 16 to 21 chick embryo. Ped Res

1993;33:22A.

28. Keller BB, Heller FA, and Tinney JP. Effect of isoproterenol induced vasodilation on ventricular pressure-volume

relations in the stage 21 chick embryo. Ped Res 1993;33:248A.

29. Casillas CB, Tinney JP, Clark EB, and Keller BB. Heart rate reserve during cardiovascular morphogenesis. Ped Res

1993;33:245A.

30. Keller B, Tinney J, Hu N, and Clark E. Embryonic ventricular pressure-volume relations in the stage 16 to 21 chick

embryo. Cardiology in the Young 1993;3:2.

31. Keller B, Murillo-Gonzalez J, Aguirra M, and Taber L. Geometric measures of the stage 9 to 14 embryonic chick heart:

relevance to hypotheses of growth and deformation during cardiac looping. Cardiology in the Young 1993;3:124.

32. Bowers P, Tinney JP, and Keller BB. Nitroprusside selectively reduces preload in the stage 21 chick embryo. Circulation

1993;88:I-148.

33. Hu N, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 24 chick embryo. Ped Res

1994;35:36A.

34. Hu N, Hansen AL, Clark EB, and Keller BB.. Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick

embryo. Ped Res 1994;35:36A.

35. Taber LA, Lin IE, Hu N, Clark EB, and Keller BB. Residual stress in the developing heart. Southern Biomedical

Engineering Conference, April 1994.

36. Bowers PN, Tinney JP, and Keller BB. Embryonic ventricular response to preload reduction produced by nitric oxide or

venous hemorrhage. (poster, AHA Scientific Conference on the Molecular, Cellular, and Functional Aspects of

Cardiovascular Development, New Orleans, 3/95)



37. Hu N, MacLennan MJ, Yoshigi M, and Keller BB. Atrial ejection volume matches ventricular active filling volume in

the stage 16 to 27 chick embryo. Ped Res 1995;37:27A.

38. Hu N, MacLennan MJ, Tinney JP, and Keller BB. Atrial pressure-volume loop characteristics in the stage 16 to 27

chick embryo. Ped Res 1995;37:27A.

39. Yoshigi M, Hu N, and Keller BB. Flow dependence of arterial impedance in stage 24 chick embryos. Ped Res

1995;37:38A

40. Bowers PN, Tinney JP, and Keller BB. Endogenous nitric oxide from L-arginine reduces preload in stage 21 chick

embryos. Ped Res 1995;37:21A.

41. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M. In vivo assessment of murine embryonic cardiovascular

function. FASEB J 1996;10:A581.

42. Hu N and Keller BB. Left atrial ligation alters intracardiac blood flow, cardiovascular growth, and function in the chick

embryo. FASEB J 1996;10:A312.

43. Tinney JP and Keller BB. Ventricular/vascular coupling and uncoupling in the embryonic cardiovascular system.

FASEB J 1996;10:A580.

44. Yoshigi M and Keller BB. Frequency domain and time domain analysis of characteristic impedance in the embryonic

chick vasculature. FASEB J 1996;10:A564.

45. Keller BB. Pulsed-Doppler investigation of embryonic cardiovascular function: applications and limitations. Ultrasound

Obst Gyn 1996;8:A57.

46. Keller BB, Miller CE, and Tsyvian P. Force-interval relationships and mechanical restitution in developing chick and

mouse myocardium. Circulation 1996;94:I120.

47. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE. Future directions in the investigation of integrated embryonic

cardiovascular physiology and mechanics. poster, 2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.

48. Yoshigi M and Keller BB: Developmental changes in wave reflection in the chick embryonic vasculature. platform talk,

2nd World Congress, Ped Card and Cardiac Surg, Honolulu, Hawaii.

49. Hu N, Smith BR, Lai CT, and Keller BB: Dependence of aortic arch morphogenesis on intra-cardiac blood flow in the

chick embryo. FASEB J 1997;11:A16.

50. Keller BB, Miller CE, Tsyvian P, Routkevich S, and Protsenko Y: Force-interval relationships in developing chick

myocardium. Effect of ryanodine and hypercalcium solutions. (poster, 33rd

International Congress of Physiological

Sciences, IUPS 1997, St. Petersburg, Russia).

51. Keller BB, Hu N, Yoshigi M, Tsyvian P, and Miller CE: Investigations in embryonic cardiovascular development: in

vivo and in vitro models. 33rd International Congress of Physiological Sciences, IUPS 1997, St. Petersburg, Russia,

July 1997.

52. Sedmera D, Rychterova V, Keller BB, and Hu N. Changes in the myoarchitecture of the left atrial-ligated heart in the

stage 34 chick embryo. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.

53. Hu N, Lai CT, McNeil EM, and Keller BB. Diastolic filling characteristics following ventricular septation in the left

atrial ligated chick. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.

54. MacLennan MJ and Keller BB. Murine embryonic umbilical arterial velocity during development and following acute

increases in heart rate. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.



55. Furukawa S and Keller BB. Influence of pregnancy on systemic blood pressure in the anesthetized and conscious

mouse. Weinstein Cardiovascular Development Conference, Cincinnati, June 1997.

56. Yoshigi M and Keller BB. Pulsatile vascular hemodynamics in the developing chick embryo. poster, Weinstein

Cardiovascular Development Conference, Cincinnati, June 1997.

57. Mangold KA, Keller BB, and Truesdell SC: Prenatal diagnosis of Down syndrome and its impact on the prevalence and

outcome of congenital heart disease. J Univ Rochester 1997;9:51.

58. Keller BB and MacLennan MJ. Murine embryonic umbilical arterial blood flow during development and following

acutely increased heart rate. Circulation 1997;96:I513.

59. Solovyeva O, Katsnelson L, Romanchenko T, Tsyvian P, Routkevich S, Markhasin V, and Keller BB. Mathematical

modeling of active embryonic myocardium mechanics (1998 American Biophysical Society Annual Scientific Sessions).

60. Keller BB and MacLennan MJ. Cardiovascular phenotypic analysis of targeted mouse embryos. Human Genome

Applications to Cardiovascular Diseases, San Diego, CA, March, 1998.

61. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo.

FASEB J 1998;12:A323.

62. McNeil EM, Campbell K, Keller BB, and Hu N: Effect of increased circulating volume on diastolic filling in the stage

21 chick embryo. FASEB J 1998;12:A323.

63. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. FASEB J,

1998;12:A324.

64. Hu N, McNeil EM, Weiss KM, Baggs R, and Keller BB: Apoptosis of ventricular myocytes following left atrial ligation

in the stage 34 chick. FASEB J 1998;12:A710.

65. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. FASEB J

1998;12:A998.

66. Tobita K and Keller BB: Average systolic myocardial stiffness is a load independent index of contractility in the

embryonic chick heart. Weinstein Cardiovascular Development Conference, Nashville, May 1998.

67. Tinney JP and Keller BB: Ventricular function after chronic conotruncal banding in the chick embryo. Weinstein

Cardiovascular Development Conference, Nashville, May 1998.

68. Furukawa S and Keller BB: Murine maternal-embryonic coupling during acute maternal hypoxia. Weinstein

Cardiovascular Development Conference, Nashville, May 1998.

69. MacLennan MJ, Tinney JP, and Keller BB: In situ measurement of ventricular blood pressure in the mouse embryo.

Weinstein Cardiovascular Development Conference, Nashville, May 1998.

70. Yoshigi M and Keller BB: Pulsatile energy expenditure in the embryonic arterial system. Third World Congress of

Biomechanics. Sapporo, JAPAN, August, 1998.

71. Keller BB: Function, biomechanics, and control of the developing cardiovascular system. The Fifth International

Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan, December, 1998.

72. Smith B, Lo CW, Keller BB, and Hu N: Magnetic resonance imaging and analysis of the embryonic and fetal heart.

The Fifth International Symposium on Etiology and Morphogenesis of Congenital Heart Disease, Tokyo, Japan,

December, 1998.



73. Tobita K and Keller BB: Developmental change of end-systolic stress-strain relations in chick embryonic ventricle.

FASEB J 1999.

74. Schroder EA, Tsyvian PB, and Keller BB: Force-velocity relations in the developing chick myocardium. FASEB J

1999.

75. Tobita K and Keller BB: Right and left ventricular epicardial strains in normal developing chick embryonic hearts.

Weinstein Cardiovascular Development Conference, Tucson, May 1999.

76. Tobita K and Keller BB: Developmental change in ventricular contractility determined from end-systolic stress-strain

relations in the chick embryo. Weinstein Cardiovascular Development Conference, Tucson, May 1999.

77. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relationship in developing chick myocardium:

Effects of nickel and mibefradil. Weinstein Cardiovascular Development Conference, Tucson, May 1999.

78. Keller BB, EA, Satin J, Tsyvian PB, and Schroder EA: Sensitivity of force-interval relationships in developing chick

myocardium to Ca2+ channel blockade. 2000 Biophysical Society Meeting, New Orleans, LA.

79. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Sensitivity of force-frequency relations in developing chick

myocardium to Ca channel blockade. J Mol Cell Cardiol 2000;32:A76.

80. Schroder EA and Keller BB: Effect of temperature on force-velocity relations in stage 24 embryonic chick

myocardium. J Mol Cell Cardiol 2000;32:A77.

81. Tobita K and Keller BB: Epicardial strain patterns in normal and left heart hypoplasia embryonic chick ventricles. J

Mol Cell Cardiol 2000;32:A28.

82. Schroder EA, Satin J, Tsyvian PB, and Keller BB: Force-frequency relations in developing chick myocardium. Exp

Clin Cardiol 2000;5:47.

83. Tobita K and Keller BB: RV and LV epicardial strain patterns in normal embryonic chick heart and following left

heart hypoplasia. Exp Clin Cardiol 2000;5:50.

84. Tobita K and Keller BB: Mechanical regulation of left ventricular development in embryonic chick ventricle.

Weinstein Cardiovascular Development Conference, St. Louis, June 2000.

85. Schroder EA and Keller BB: Effects of temperature on force-velocity relations in the developing chick myocardium.

Weinstein Cardiovascular Development Conference, St. Louis, June 2000.

86. Tobita K, Schroder EA, Tinney JP, and Keller BB: Passive biaxial ventricular pressure-strain relations during normal

development and altered loading conditions in the chick embryo. Weinstein CV Development Conference, Dallas, May

2001.

87. Tobita K, Tinney JP, and Keller BB: Assessment of embryonic mouse heart function using Doppler echocardiography

and maternal isoflurane anesthesia. Weinstein Cardiovascular Development Conference, Dallas, May 2001.

88. Sedmera D, Hu N, Keller BB, Denslow S, and Thompson RP: Label-dilution approach to study changes in cell

proliferation: a teratologist’s dream come true. Weinstein Cardiovascular Development Conference, Dallas, May 2001.

89. Keller BB, Tinney JP, and Tobita K: Cardiovascular phenotype assessment using transabdominal echocardiography

and maternal anesthesia. Poster, World Congress of Pediatric Cardiology and Cardiac Surgery, Toronto, May 2001.

90. Tobita K, Tinney JP and Keller BB: Passive biaxial ventricular wall stress-strain relations during normal and altered

load in the chick embryos. Experimental Biology, Orlando, FL 2001.



91. Garrison JB, Tobita K, Keller BB: Effects of cyclic stretch stimulation on embryonic ventricular cell orientation and

shape. University of Kentucky Gill Cardiovascular Research Symposium, Lexington, KY, October 2001.

92. Schroder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered

mechanical load. Biophysics Society Meeting, San Francisco, CA, February 2002.

93. Tobita K, Garrison JB, and Keller BB: Three-dimensional fiber architecture of the embryonic left ventricle during

normal development and reduced mechanical load. Weinstein Cardiovascular Development Conference, Salt Lake City,

May 2002.

94. Schroeder EA, Tobita K, Tinney JP, Foldes J, and Keller BB: Microtubule involvement in the adaptation to altered

mechanical load in developing chick myocardium. Weinstein Cardiovascular Development Conference, May 2002.

95. Poma CP, Shulimovich M, Tobita K, Keller BB, Pennisi D, and Mikawa T. Hemodynamics induce and pattern

purkinje fiber differentiation. Weinstein Cardiovascular Development Conference, Salt Lake City, May 2002.

96. Tobita K, Garrison JB, and Keller BB: Developmental change of three-dimensional fiber architecture of the

embryonic left ventricle during reduced mechanical load. Comparative Physiology Roundtable Meeting, Glenn Rose,

TX 2002.

97. Tobita K, Garrison JB, and Keller BB: Differential effects of cyclic stretch on embryonic ventricular myocyte and non-

myocyte orientation. Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Post-Genomic Era: New

Takao Symposium, Tokyo, Japan, December 2002

96. Tobita K, Tinney JP, and Keller BB: Residual strain in embryonic left ventricle following normal and altered

mechanical

load in the chick embryo. Weinstein Cardiovascular Development Conference, Boston, MA, May 2003.

97. Nordman CR, Tobita K, Lucitti JL, and Keller BB: Impact of chronic hypoxia exposure on vascular impedance in

early developing chick embryo. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session,

August 2003

98. Nonemaker JL, Tobita K, Liu LL, and Keller BB: Response of microtubule network to mechanical stretch in embryonic

ventricular cells. 2003 Children's Hospital of Pittsburgh Summer Student Research Poster Session, August 2003

99. Tobita K, Liu JL, and Keller BB: Engineered three-dimensional cardiac tissue from early embryonic chick

myocardium. Tissue Engineering Society International, 6th Annual International Conference and Exposition, Orlando,

FL, October 2003

100. Sharma S, Tobita K, Tinney JP, and Keller BB: Regulation of cardiovascular structure and function by oxygen

tension in chick embryos. 2004 American Heart Association Research Fellow Symposium, Pittsburgh, February 2004

101. Lucitti JL, Tobita K, and Keller BB: Impact of altered mechanical load on dorsal aortic impedance in the developing

chick embryo. 2004 McGowan Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004

102. Tobita K, Liu LL, Tinney JP, and Keller BB: Engineered embryonic cardiac tissue: Initial Experience. 2004 McGowan

Institute for Regenerative Medicine Planning Retreat. Nemacolin, February 2004

103. Saaloukeh ME, Tobita K, Momoi N, Tinney JP, Keller BB: Adverse effects of caffeine on embryonic cardiac function

during early cardiac morphogenesis. Midwest Society for Pediatric Research Meeting, St. Louis, MO, 2004.

104. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac tissue

(EEECT). Joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society,

Lausanne, Switzerland, 2004

105. Lucitti JL, Tobita K, and Keller BB: Altered mechanical load impacts arterial hemodynamics and structure during

cardiogenesis. Experimental Biology 2004. FASEB JOURNAL v.18(#4), pp. A1247-A1247. 2004.



106. Lucitti JL, Tobita K, Keller BB: Impact of altered mechanical load on dorsal aortic impedance during cardiovascular

morphogenesis. Weinstein Cardiovascular Development Research Meeting, Leiden, Netherlands 2004

107. Momoi N, Tobita K, Tinney JP, Saaloukeh ME, Liu JL, Elshershari H, Keller BB, Adverse effects of caffeine on

embryonic cardiac function during early cardiac morphogenesis. PAS meeting, Washington DC, 2005

108. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Gabriel S, Clark R, Keller BB. Preterminal gasping is

associated with increased cardiac output and increased time till cardiac arrest in immature rats exposed to anoxia. PAS

meeting, Washington DC, 2005

109. Lucitti JL, Tobita K, and Keller BB. Impact of altered mechanical load on dorsal aortic impedance during

cardiovascular morphogenesis. 2004 Weinstein Cardiovascular Development Meeting. Leiden, the Netherlands.

110. Tobita K, Liu LJ, Janczewski AM, Shroff SG, Keller BB: Three-dimensional engineered early embryonic cardiac

tissue (EEECT). Tissue Engineering Society International 7th

Annual International Conference and Exposition and

joint meeting of the Tissue Engineering Society International and the Europe Tissue Engineering Society, Lausanne,

October, 2004.

111. Fujimoto, KL, Tobita K, Momoi N, Keller BB, Guan J, and Wagner WR : Cardiac remodeling by elastic biodegradable

cardiac patch covering the infarction area. 2005 McGowan Institute for Regenerative Medicine Planning Retreat.

Nemacolin, March 2005

112. Lucitti JL and Keller BB: Increased arterial load impacts pulse wave velocity in chick embryos. Experimental Biology

2005, San Diego, CA

113. Tobita K, Liu JL, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, Keller BB.

Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing

embryonic myocardium. Weinstein Cardiovascular Development Research Meeting, St. Petersburg, FL 2006

114. Fujimoto KL, Tobita K, Momoi N, Keller BB, Guan J, Wagner WW : Elastic, biodegradable cardiac patch induces

contractile smooth muscle bundles in sub-acute myocardial infarction, improving cardiac remodeling and function.

American Heart Association 2005 Scientific Sessions, Dallas, TX

115. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Peault B, Huard J. Identification of a

progenitor cell population from human skeletal muscle that is superior to committed skeletal myoblasts for cardiac cell

therapy. AHA-BCS meeting, Denver, CO, 2006.

116. Keller BB, Liu LJ, Tinney JP, Tobita K. Lessons from embryos: insights into cardiovascular morphogenesis and

adaptation. World Congress of Biomechanics, Munch, Germany, 2006.

117. Tobita K, Choi B, Liu LJ, Chey E, Tinney JP, Salama G, Keller BB. Impact of cyclic electric stimulation on

engineered early embryonic cardiac tissue. World Congress of Tissue Engineering, Pittsburgh, PA 2006.

118. Ahmad F, Lage ML, Janczewski AM, Tobita K, Smith S, Saba S, Conner DA, Tinney JP, Ragwe J, Moskiwitz IP,

Perez-Atayde AP, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. Cardiomyopathies secondary to

cardiac troponin T mutations result from abnormal protein function rather than haploinsufficiency. AHA annual

meeting, Chicago, 2006.

119. Funari BJ, Witt MR, Clause KM, Keller BB, Tobita K, Ralphe JC. The impact of energy substrate on contractile

performance in a neonatal rat engineered cardiac tissue model. 2007 Pediatric Academic Societies’ meeting, Toronto,

2007.

120. Kreutzer J, Emery SP, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Novel computer

assisted electromagnetic navigation for prenatal catheter intervention. Pediatric Interventional Cardiac Catheterization

Conference, Las Vegas, NV, 2007



121. Clause K, Tinney JP, Liu JL, Keller BB, Tobita K. p38 MAP-kinase regulates engineered early embryonic cardiac tissue

proliferation and contractile properties. Weinstein Cardiovascular Development Research Meeting, Indianapolis, IN

2007.

122. Clause K, Tinney JP, Liu JL, Burhan B, Fujimoto KL, Wagner W, Ralphe JC, Keller BB, Huard J, Tobita K.

Functioning engineered cardiac tissue from skeletal muscle derived stem cells. Weinstein Cardiovascular Development

Research Meeting, Indianapolis, IN 2007.

123. Momoi N, Tinney K, Liu JL, Elshershari H, Hoffman P, Ralphe JC, Keller BB, Tobita K. Modest maternal caffeine

exposure affects developing embryonic cardiovascular function and growth. Weinstein Cardiovascular Development

Research Meeting, Indianapolis, IN 2007.

124. Paladino LK, Keller SJ, Keller JM, Farrington J, Andre D, Wolf D, Gu H, Wang SB, Keller BB. Heart Rate, Oxygen

Saturation, and Blood Pressure Response to Exercise in Children With and Without Congenital Heart Disease at High

Altitude in the Tibet Autonomous Region, PRC. 2007 Children's Hospital of Pittsburgh Summer Student Research

Poster Session.

125. Park G, Clause KC, Tinney JP, Liu JL, Gharaibeh B, Fujimoto KL, Wagner W, Huard J, Keller BB, Tobita K.

Cardiomyocyte induction from skeletal muscle derived stem cells (MDSCs) using MDSC sphere formation and 3-

dimensional MDSC-engineered cardiac tissue construction. 2007 Children's Hospital of Pittsburgh Summer Student

Research Poster Session.

126. Freytes DO, Tobita K, Tinney JP, Keller BB, Wainwright JW, Martin J, Velankar SS, Badylak SF. Extracellular

Matrix Derived Gel for Cardiac Tissue Engineering Applications. International Biomaterial Meeting, Orlando, FL,

2007

127. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB. Phillippi JB, Peault B, Huard J.

Identification of a lineage of myogenic-endothelial cells in adult human skeletal muscle that are superior to myoblast

for myocardial infarct repair. 5th Annual Meeting International Society for Stem Cell Research Cairns, Australia,

2007.

128. Fujimoto KL, Tobita K, Guan J, Keller BB, Wagner WR. Elastic, biodegradable cardiac patch implantation induces

embryonic-like cellularization in the post-infarct ventricular wall. AHA annual meeting, Orlando, FL, 2007.

129. Emery SP, Kreutzer J, Sherman F, McCaffery F, Keller BB. Learning curve for a fetal cardiac intervention team.

Society for Maternal-Fetal Medicine 28th Annual Scientific Meeting, Dallas, TX, 2008.

130. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Pekkan K, Keller BB. Hemodynamic investigation of normal

developing aortic arch in the chick embryo. ASME 2008 Summer Bioengineering Conference (SBC2008) Marco

Island, Florida, USA

131. Drummond A, Keller BB, Borovetz HS, Antaki JF. Anatomic database for insertion of VADS in infants and young

children.ASME 2008 Summer Bioengineering Conference (SBC2008) Marco Island, Florida, USA

132. Drowley L, Okada M, Tobita K, Keller BB, Huard J. Treatment of muscle stem cells with N-acetylcysteine increases

survival and resistance to stress. Tissue Engineering and Regenerative Medicine International Society 2008.

133. Wang Y, Patrick MJ, Dur O, Keller BB, Pekkan K. Hemodynamic investigation of normal aortic arch development

in the chick embryo. Carnegie Mellon University 2008 Bioimaging Conference, Pittsburgh, PA

134. Dur O, Pekkan K, Dasi LP, Keller BB, Fogel MA, Yoganathan A. In vitro hemodynamics of embryonic aortic arch

with tetralogy of Fallot at late gestation. 2008 CalTech Biofluids Conference, Pasadena, CA

135. Ralphe JC, Witt M, Kirk J, Clause KM, Keller BB, Tobita K. Engineered Neonatal Rat Cardiac Tissue Models

Immature in vivo Myocardium. American Heart Association 2008 Scientific Sessions, New Orleans, LA. Circulation

2008;118:S 281



136. Drowley L, Cassino T, Okada M, Tobita K, Keller BB, LeDuc P, Huard J. Stem Cell Transplantation for Cardiac

Repair is improved by Mechanical Preconditioning. Experimental Biology 2009.

137. Clause K, Li, JL, Powell MC, Keller BB, Gharaibeh B, Huard J, Tobita K. Skeletal muscle specific fast myosin heavy

chain is present in the developing ventricular myocardium. NHLBI Symposium on Cardiovascular Regenerative

Medicine, Bethesda, October, 2009

138. Dur O, Wang Y, Patrick MJ, Tinney J, Keller BB, Pekkan K. Correlation of wall shear stress and pharyngeal arch

lumen diameter during early embryonic development in the chick, Biomedical Engineering. Society Annual Fall

Meeting, Pittsburgh, PA, October 2009.

139. Clause KC, Tinney JP, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB,

Tobita K. Impact of cyclic mechanical stretch on muscle stem cell derived cardiomyocyte 3D engineered tissue.

Biomedical Engineering. Society Annual Fall Meeting, Pittsburgh, PA, October 2009.

140. Pekkan K, Jamaly M, Kara B, Sotiropoulos F, Keller BB. Early embryonic intra-cardiac flow fields at three idealized

ventricular morphologies, APS Division of Fluid Dynamics 62nd Annual Meeting, November 2009

141. Kowalski WJ, Dur O, Keller BB, Pekkan K. Investigating the growth and remodeling of the embryonic aortic arch

manifold through a CFD coupled 2D optimization framework. Sixth MIT Conference on Computational Fluid and

Solid Mechanics, Cambridge, MA, June 2010

142. Jackson D, Blake J, Miller D, Naber J, Walsh K, Woods C, Keller BB, Reimer P, Beeler S. A Wireless Body

Temperature Monitor for the Prevention of Febrile Seizures. 6th Annual Kentucky Innovation and Entrepreneurship

Conference, Lexington, K, 2010

143. Keller BB, Downs-Canner S, Hornung CA, Gu H. Detection of congenital heart disease using 5 minute exercise

screening for high altitude, rural Tibetan children. 20th World Congress of the World Society of Cardio Thoracic

Surgeons, Chenai, India, October 2010.

144. Geppert M, Wang SB, Laba ZM, Ren QCW, Meiji M, Kai W, Ng L, Geppert M, Neches WH, Yong BH, Nakanishi T,

Gu H, Keller, BB. Mid-term results of the screening and treatment of congenital heart disease at high altitude: The

Touching Hearts in Tibet Program. 20th World Congress of the World Society of Cardio Thoracic Surgeons, Chenai,

India, October 2010.

145. Wang Y, Ferreira A, Keller BB, Simon M, Antaki JF. Effect of continuous-flow left ventricular assist device on

cardiac function: simulation study with a refined computer model. ASME 2011 Summer Bioengineering Conference

SBC2011, June 22-25, Farmington, PA

146. Tchao JS, Clause KC, Keller BB, Huard J, Shroff S, Franks J, Davidson L, Tobita K. Local mechanical strain

influences cardiomyocyte differentiation in skeletal muscle stem cell within 3-dimensional collagen gel bioreactor.

NHLBI Symposium on Cardiovascular Regenerative Medicine, DC, 2011.

147. Black AK, Raymon S, Hornung C, Mascio C, Keller BB. Interim results of the pediatric cardiovascular home

telehealth project. Research Louisville!2011. Louisville, KY October, 2011

148. Sadanala U, Ymalay R, Raymon S, Tinney JP, Kriss V, Keller BB. Initial observations using high resolution

VEVO2100 ultrasound imaging in neonates. Research Louisville!2011. Louisville, KY October, 2011

149. Kmetz DJ, Tinney JP, Dale J, Krishnan L, Hoying JB, Keller BB. Characterization of vascular maturation within

engineered cardiovascular tissues. Research Louisville!2011. Louisville, KY October, 2011



150. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high

resolution ultrasound imaging in neonates. Souther Society for Pediatric Research, New Orleans, February 2012.

Accepted for poster presentation.

151. Black AK, Raymon S, Hornung C, Mascio C, Keller BB. Interim results of the pediatric cardiovascular home

telehealth project. American Pediatric Society, Boston, MA, May 2012 (in review)

152. Ymalay R, Sadanala U, Tinney JP, Kriss V, Keller BB. Initial observations and limitations of VEVO2100 high

resolution ultrasound imaging in neonates. American Pediatric Society, Boston, MA, May 2012 (in review)

L. Patent Filings

1. Biodegradable Elastomeric Patch for Treating Cardiac or Cardiovascular Condition. Inventors: William Wagner, Kazuro L.

Fujimoto, Kimimasa Tobita, Bradley B. Keller. University of Pittsburgh. Serial No.: 60/808,980 Filed June 27, 2006, Country:

US-Provisional

2. Functioning Cardiomyocyte Induction from Skeletal Muscle Derived Stem Cell using Rotation and 3-Dimensional Collagen

Culture. Inventors: Kimimasa Tobita; Johnny Huard; Kazuro L. Fujimoto; Bradley B. Keller. IDF 1518. Disclosure Filed

June 27, 2007. University of Pittsburgh



M. Research Funding

GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT

Ventricular Mechanics in the Developing Chick Heart. 07/01/88 - 06/31/90 $53,400

PI, 85% FTE, NIH-NRSA #F32-HL07824.

Ventricular Mechanics in the Chick Embryo 07/01/90 - 06/31/95 $371,730

PI, 85% FTE, NIH-PSA-K11-HL02498.

Calcium Kinetics in the Embryonic Chick Myocyte 07/01/91 - 06/31/93 $6,000

PI, Univ. of Roch. Strong Childrens Research Center

Ventricular Mechanics in the Developing Embryonic Heart 07/01/91 - 06/31/96 $854,095

L. Taber, PI, B. Keller, co-PI, 10% FTE, NIH-RO1-HL46367.

Ventricular/Vascular Coupling in the Chick Embryo 07/01/93 - 06/31/96 $118,000

PI, 20% FTE, American Heart Association, Grant-in-Aid, 93-1013

NIH SCOR: Bench to Bedside, Biomechanics of the 05/31//93 - 12/31/98 $4,750,000

Developing Cardiovascular System. 75% FTE, NIH-P50-HL51498

E. Clark, PI 1/1/93 - 5/31/95, B. Keller, PI 5/31/95 – 12/31/98

Murine Embryonic Cardiovascular Functional Maturation 07/01/95 - 06/31/96 $15,000

PI, 15% FTE, Strong Childrens Research Center

Mechanical Properties of Chick Embryonic Myocardium 07/01/95 - 06/31/98 $60,000

Fogarty International Award. B. Keller, P.I., 5% FTE;

P. Tsyvian, Russian collaborator, NIH-RO3-TW00527

Active Myocardial Mechanics During Development and Disease 07/01/97 - 06/31/99 $45,000

PI, 5% FTE, Civilian Research and Development Foundation, #5270

V. Markhasin, Russian co-PI

In Utero Murine Embryo CV Phenotype Screening 09/01/00 - 07/31/04 $1,480,897

B. Keller, PI, 30% FTE, NHLBI RFA RO1 HL65219-01

Adaptation of the embryonic myocardium to altered load. 02/01/01 - 01/31/05 $1,421,951

B. Keller, PI, 30% FTE, NHLBI RO1 HL64626-01-A1

Modulation of T-type Calcium Channels. J. Satin, P.I. 07/01/00 - 06/31/04 consultant

NHLBI RO1 HL63416-01 B. Keller, consultants

Biomechanical Adaptation of Embryonic Myocardium to 09/01/00 - 08/31/03 $18,000

Chronic Hemodynamic Alteration. NATO Collaborative Linkage Grant.

B. Keller, PI, P. Tsyvian, Partner Country PI

Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 $58,500

PNC Charitable Trust. B. Keller, PI

Novel Technology Development for Fetal Cardiac Intervention 12/01/03 - 11/31/04 $60,000

Pittsburgh Life Science Greenhouse award to Verimetra, Inc,

B. Keller, PI CHP subcontract

NIH SBIR Circulatory Support Device for Toddlers/Small Children 02/04 - 01/05 consultant

J. Antaki (Launch Point Technologies), PI, B. Keller, CHP subcontract PI, 3% FTE



GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Prenatal Fetal Cardiovascular Interventions 10/01/03 – 09/31/04 consultant

NHLBI Phase I SBIR, CASurgica, Inc, B. Keller, CHP consultant R43HL076961-01

NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $13,450,000

Optimizing Outcomes After Pediatric Heart Transplantation

S. Webber, PI, B. Keller, co-PI, 10% FTE P50-HL074732-02

NIH BAA Pediatric Ventricular Assist Device for the 3 to 15 Kilogram 03/15/04 – 02/14/09 $4,490,691

Patient. H. Borovetz, PI, B. Keller, CHP subcontract PI, 8% FTE NIH- HSN268200448192C

Engineered Early Embryonic Cardiac Tissue (EEECT) 05/15/05 - 03/31/07 $387,665

B. Keller, PI, 20% FTE, NHLBI R21 HL079998-01

Prenatal Fetal Cardiovascular Interventions 04/01/06 – 03/31/08 $272,875

NHLBI Phase II SBIR, CASurgica, Inc, B. Keller, PI CHP subcontract, 15% FTE,

NIH/NHLBI 2R44 HL076961-02A1

Tissue Engineered Grafts for Congenital Heart Surgery 7/1/06 – 5/31/07 $60,000

PA Department of Health, MIRM, B. Keller, PI

MEMS Blood Pressure Sensor for Pediatric VAD 07/01/07 - 05/31/08

B. Norling, PI (Launchpoint Technologies), B. Keller, consultant

NIH SBIR R43-HL087446-01-A1

Bioengineering Analysis of Embryonic Hypoplastic Aortic Arch 07/01/07 – 06/31/09 $132,000

During the Period of Arterial Morphogenesis. K. Pekkan (CMU), PI, B. Keller, Co-I,

Mid-Atlantic AHA Affiliate Beginning Grant-in-Aid

Mitochondrial Maturation and Function in the Engineered Embryonic 07/01/07 – 06/31/09

Heart Model J. Carter Ralphe, PI, B. Keller, consultant, Mid-Atlantic AHA Affiliate Grant-in-Aid

Engineered Cardiac Tissues for Pediatric and Adult Patients 7/1/07 – 5/31/08 $60,000

PA Department of Health, MIRM, B. Keller, PI

VisualSonics Vevo770 Ultrasound Biomicroscopy and Microinjection Core. 09/29/0 7 377,815

B. Keller, PI NCRR/NIH 1S10RR024741-01

Magnetic Navigated Image Overlay for Vascular Access- MNIO-VA 12/1/07 – 07/31/09 147,279

B. Keller, PI, NIH 1R41HL091553-01

Engineered Early Embryonic Cardiac Tissue 07/01/08 – 06/31/12 1,817,125

B. Keller, PI, NHLBI RO1 HL085777-01-A2

PELEX-C: A high-resolution wireless ECG system for infants/children 09/01/08 – 08/31/09 155,815

B. Keller, PI (PinMed, Inc). NIH R41HL093953-01

Ultrasound-Enhanced Gene Delivery Validation in Genetic Mouse Models 07/01/08-06/31/09 50,000

E. Goetzman and B. Keller co-PIs, VisualSonics, Inc. product enhancement grant

Three-Dimensional Cardiac Gel Bioreactor for Functioning 07/01/09 – 11/30/11 250,000

Cardiomyocyte Induction from Human Skeletal Muscle Derived Stem Cells

K. Tobita PI, B. Keller, co-I, NHLBI R21 HL094402-01



GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT A Wireless Temperature Monitor for Children 01/01/10 – 12/31/10 75,000

J. Naber, PI, B. Keller, co-PI (5% FTE) and Simon Sounds, Inc. Kentucky Commercialization Funds

University of Louisville Pediatric Home TeleHealth Demonstration 07/01/10 – 06/31/12 $200,000

Project: Home TeleCare for High-Risk Pediatric Cardiac Patients

B. Keller, PI (10% FTE). University of Louisville Clinical Translational Science Pilot Project Program

Regenerative Potential of Umbilical Cord Derived Mesenchymal Stem 08/01/11 – 07/31/12 $50,000

Cells in Pediatric Cardiovascular Repair.

L. Krishnan, PI, B. Keller, co-PI (NSS). Kosair Charities Pediatric Heart Research Program Pilot Grant

RESEARCH PROPOSALS IN REVIEW Aortic Arch Biomechanical Selection and Remodeling in the Chick Embryo (04/01/12 -03/31/17) $1,109,931

K. Pekkan, M-PI, B. Keller, M-PI NIH 1R01HL111387-01A1(15th percentile)

A non-contact, low-cost, passive blood pulse profilometer for the 07/01/12 – 12/31/12 $17,112

assessment of CV health and the long term monitoring of CV history

J. Hay (RDI, Inc) PI, B. Keller, co-I (5% FTE) NIH R43 HL110578-01A1

A disposable immunoassay for rapid diagnosis of cardiac and 07/01/12 – 06/30/13 NSS

inflammatory events.

A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant (NSS) NIH R43 SBIR Phase I

Blood filtration system for the treatment of severe malaria patients 07/01/12 – 06/30/13 NSS

inflammatory events.

A. Gandini (Tropical Health Systems, LLC) PI, B. Keller, consultant (NSS) NIH R43 SBIR Phase I

Multidisciplinary Training in Cardiovascular Research. 12/01/12 -11/30/17 NSS

A. Batnagar, PI, B. Keller, mentor NIH NHLBI T32

Pediatric Asthma Care Integration and Point-of-Care Innovation 04/01/12 – 03/31/15 $9,217,849

B. Keller, PI CMMI Grants.gov Tracking Number:GRANT11043612

RESEARCH PROPOSALS IN REVISION

University of Louisville’s Clinical and Translational Sciences Institute 07/01/1* – 06/31/1*

C. McClain, PI, B. Keller, co-I (15% FTE) NIH U54 RR026087-01-A3

Pressure-Flow Relations and Mechanical Support in Failing Fontan 12/01/1* – 11/30/1*

K. Pekkan, PI, B. Keller, co-I, NHLBI R21 (in revision)

Comparative Effectiveness of Ultrasound-Guided Nerve Blocks vs. 01/01/1* – 12/31/1*

Procedural Sedation for Pediatric Orthopedic Injuries"

K. Cross, PI, B. Keller, Primary Mentor, NIH K23 HD068551-01 (NSS)

Ultra-thin Anisotropic Conducting Cardiac Biofabric. 12/01/1*– 11/30/1*

E. Boland, PI, B. Keller, co-I , 1R01 HL105724-01A1

Three-Dimensional Heart Patch for Ischemic Myocardium 07/01/1* – 06/31/1*

S. Williams, PI, B. Keller, co-I (5% FTE), NIH 1R01 HL106095-01

A non-contact, low-cost, passive respiration monitor capable for use 07/01/1* – 06/30/1*

in detecting apnea and respiratory function

J. Hay (Research, Design, and Innovation Tech.) PI, B. Keller, co-I (5% FTE) NIH R43 SBIR Phase I



MENTORED TRAINING GRANTS

GRANT TITLE, NUMBER, AND PERCENTAGE EFFORT YEARS AMOUNT Creation and Palliation of Functional and Structural 07/01/98 - 06/31/00 $70,000

Cardiovascular Defects in Chick Embryos. K. Tobita, fellow, B. Keller, sponsor AHA Fellowship Award (NY State

Affiliate)

Functional Maturation of Embryonic Myocardium. 07/01/99 - 06/31/02 $135,000

E. Schroder, PI, B. Keller, sponsor, 1F32-HL10200 NIH-individual NRSA post-doctoral fellowship award


E. Schroder, PI, B. Keller, sponsor AHA, Ohio Affiliate, Individual post-doctoral fellowship award (declined due to NIH award)

NHLBI RFA SCCOR in Pediatric Cardiovascular Disease 01/01/04 - 12/31/09 $500,000

Optimizing Outcomes After Pediatric Heart Transplantation, B. Keller, PI, Clinical Research Training Core

NHLBI Cardiovascular Bioengineering Training Grant. 02/01/05 - 01/31/10 mentor

S. Shroff, NIH T32HL76124-01 A1 PI, B. Keller, faculty mentor


NIH clinician/scientist training award K08 NIH HL074224-A1, J. Carter Ralphe, PI, B. Keller, sponsor

Simulation of Optimal Surgical Insertion of a Pediatric Ventricular 07/01/07 – 06/31/12 mentor

Assist Device. NIH K31 HL090267-01. A. Drummond, PI, B. Keller, mentor

Role of mechanical forces on cardiomyocyte induction from 07/01/08 – 06/31/10 mentor

skeletal muscle derived stem cells in 3D culture. AHA pre-doctoral fellowship. K. Clause, PI

Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/11 mentor

Cardiovascular Disease? American Diabetes Association Beginning Faculty Award I. Libman, PI

Are Overweight Children with T1DM at Increased Risk of 07/01/08 – 06/31/13 mentor

Cardiovascular Disease? NIH clinician/scientist training award K23 HL085287-01-A2 I. Libman, PI

Oxidative stress in regional cerebral blood flow alterations 07/01/08 – 06/31/13 mentor

after pediatric cardiac arrest. NIH clinician/scientist training award K08 HD058798-01 M. Manole PI



CLINICAL RESEARCH GRANTS AND PROTOCOLS

PATH-1, Pediatric use of Amlodipine in the Treatment of 07/01/99 - 06/31/00 $75,000

Hypertension. Pfizer Central Research, J.D. Moore, site-PI, University of Kentucky, B. Keller, co-P.I.

Long-term Outcomes in Adult Congenital Heart Disease 07/01/00 - 07/31/02

B. Keller, PI, IRB#00-0482-P1R (University of Kentucky)

Anatomic Modeling of Pediatric Patients for PVAD 07/01/06 – 06/30/08

B. Keller, PI, CORID #85 (University of Pittsburgh)

Accuracy of Heart Rate and Oxygen Saturation Response to Exercise 07/01/07 – 05/01/09

At High Altitude (Tibet) to Detect Congenital Heart Disease, B. Keller, PI, SEAPC

University of Pittsburgh IRB Protocol #PRO08030108 Approved 5/12/08 (200 subjects)

PELEX-C: A high-resolution wireless ECG system for infants/children 07/01/07 – 05/01/09

B. Keller, PI, NIH/NHLBI, University of Pittsburgh IRB Protocol #PRO07100403 (5/15/08 -5/1/09)

Pediatric Cardiovascular Home Telehealth Project 12/22/11 – 12/21/12

B. Keller, PI, University of Louisville IRB Protocol # 10.0619, NHORA# 10.0201

Capillary Leak Syndrome 04/01/11 – 03/31/12


High Resolution Ultrasound Imaging in Neonates 04/14/11 – 04/13/12


Self-management of oral anticoagulation therapy with web-based 04/14/11 – 04/13/12

decision support in children with cardiac indications for anticoagulation protocol

B. Keller, PI, University of Louisville IRB Protocol (in revision)

N. Clinical Service: Inpatient and outpatient pediatric cardiology since 7/1/91 without interruption 1. Ambulatory Pediatric Cardiology Office Hours in Louisville.

2. Outreach Pediatric Cardiology Office Hours at sites throughout the Commonwealth of Kentucky and southern Indiana.

Paducah, Bowling Green, Elizabethtown, Glasgow, Campbellsville, Owensboro, Madisonville, Madison, Ashland, Murray

3. Inpatient Pediatric Cardiology Attending service at Kosair Children’s Hospital and Norton Hospital.



O. Publications, Book Chapters, Monographs and Textbooks INVITED REVIEWS

1. Keller BB and Clark EB: Cardiovascular structural and functional maturation. Current Opinion in Cardiology 1993;8:98-107.

2. Keller BB: Functional maturation and coupling of the embryonic cardiovascular system. In Developmental Mechanisms of

Heart Disease, (eds) EB Clark, RR Markwald, and A Takao, Futura Publishing, Mount Kisco, NY, 1995, 367-386.

3. Keller BB: Function, biomechanics and control of the embryonic cardiovascular system. In Etiology and Morphogenesis of

Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology. (eds) EB Clark, M Nakazawa,

and A Takao, Futura Publishing, Mount Kisco, NY, 2000, 271-274

4. Keller BB: Function and biomechanics of developing cardiovascular systems. In Formation of the Heart & Its Regulation. (ed)

R Tomanek. Springer-Verlag, 2001,251-271.

5. Keller BB: Practical applications derived from basic studies of developing cardiovascular systems. In Comparative

Developmental Physiology: Contributions, Tools and Trends. (eds) SJ Warburton, WW Burggren, B Pelster, CL Reiber and J

Spicer. Oxford University Press, Inc, USA, 2006, 148-160.

BOOKS 1. Burggren WW and Keller BB: Development of Cardiovascular Systems: Molecules to Organisms. Cambridge Univ Press,

New York, 1997, 360 pages.

BOOK CHAPTERS

1. Keller BB: Heart Failure. In Primary Pediatric Care, ed 2; (eds) Hoekelman RA, Friedman SB, Nelson NM, Seidel HM, CV

Mosby Co, St Louis, 1990,pp1620-1621, and ed 3, 1997,pp1713-4.

2. Keller BB. Embryonic Cardiovascular Function, Coupling, and Maturation: A Species View. In Development of

Cardiovascular Systems: Molecules to Organisms. (eds) Burggren W and Keller BB. Cambridge Univ Press, New York,

1997, pp65-87.

3. Keller BB and Markwald RR. Embryonic Structural and Functional Cardiovascular Maturation. In The Heart: Arteries and

Veins, ed 9; (eds) Hurst JW, Logue RB, Rackley CE, Schlant RC, Sonnenblick EH, Wallace G, Wenger NK, McGraw-Hill

Book Co, New York 1998, 195-221.

4. Keller BB. Analysis of Murine Embryonic Structural and Functional Phenotype. In Cardiovascular Physiology in the

Genetically Engineered Mouse. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York, 1998;259-280.

5. Keller BB, Wessels A, Schwartz Roberts R, and Markwald RR. Molecular Development and Embryology of the Heart. In

Hurst’s the Heart, ed 10; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-

Hill Book Co, New York 2000,167-192.

6. Tobita K, Tinney J, and Keller BB. Cardiovascular Phenotype Analysis of Murine Embryos. In Cardiovascular Physiology in

the Genetically Engineered Mouse, 2nd

Edition. (eds) Hoit BD and Walsh RA. Kluwer Academic Publishers, New York 2002,

353-376.

7. Schroder EA, Satin J, Routkevitch S, Tsyvian P, and Keller BB. T-type and L-Type Calcium Currents Modulate Force in

Embryonic Chick Myocardium. In Cardiac Development. (eds) Ostadal B, Nagano M, and Dhalla NS. Kluwer Academic

Publishers, Boston 2002, 113-132.

8. Keller BB, Wessels A, and Markwald RR. Molecular Development and Embryology of the Heart. In Hurst’s the Heart, ed

11; (eds) Fuster, V, Roberts R, Alexander RW O’Rourke RA, King SP III, and Wellens HJJ, McGraw-Hill Book Co, New York

2004, 155-180

9. Tobita K, Garrison JB, and Keller BB. Differential effects of cyclic stretch on embryonic ventricular cardiomyocyte and

non-cardiomyocyte orientation. In Cardiovascular Development and Congenital Malformations: Molecular and Genetic



Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 177-179.

10. Keller BB. Physiology and biomechanics of developing cardiovascular systems: expanding frontiers. In Cardiovascular

Development and Congenital Malformations: Molecular and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava

D, Nakazawa M. Blackwell Futura, Malden, MA 2005, 180-185

11. Tobita K, Garrison JB, and Keller BB. Three-dimensional fiber architecture of the embryonic left ventricle during normal

development and reduced mechanical load. In Cardiovascular Development and Congenital Malformations: Molecular

and Genetic Mechanisms(eds) Artman M, Benson DW, Srivastava D, Nakazawa M. Blackwell Futura, Malden, MA 2005,

186-189

12. Kaushik N, Wessels A, Markwald RR, and Keller BB. Molecular Development and Embryology of the Heart. In Hurst’s

the Heart, ed 12; (eds) Fuster, V, O’Rourke RA, Walsh RA, Wilson PP, McGraw-Hill Book Co, New York 2008, 155-176

13. Keller BB. Genetic and Epigenetic Mechanisms for Congenital Heart Disease. In: Pediatric Heart Disease: A Practical

Guide; (eds) Daubeney PE, Rigby M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2007

14. Burggren W, Chapman K, Keller B, Monticino M, and Torday J. Interdisciplinarity in the Biological Sciences. In:

Handbook of Interdisciplinarity. Oxford University Press 2010, 119-132

15. Keller BB, Hoying JA, Markwald RR. Molecular Development of the Heart. In Hurst’s the Heart, ed 13; (eds) Fuster, V,

Walsh RA, Harrington RA, McGraw-Hill Book Co, New York 2011, 172-194

16. Keller BB. Epidemiology and Genetics. In: Pediatric Heart Disease: A Practical Guide; ed 2; (eds) Daubeney PE, Rigby

M, Niwa K, and Gatzoulis MA, Blackwell Publishing, Edinburgh, UK 2012

LETTERS TO THE EDITOR

1. Tobita K and Keller BB. Response to comments on embryonic stress-strain measurements. Am J Physiol 2001;281:464-466.

INVITED EDITORIALS

1. Keller BB. Developmental structure-function insights from the Tbxfdel/+

mouse model of Holt-Oram syndrome. Am J

Physiol Heart Circ Physiol 2005;289:H975-H976.

2. Keller BB. New insights into the developmental biomechanics of the atrioventricular valves. Circ Res 2007;110:1399-

1401



ARTICLES (first or senior author)

1. Keller BB, Mehta AV, Shamszadeh M, Marino TA, Sanchez GR, Huff DS, Dunn JF: Oncocytic Cardiomyopathy of Infancy

With Wolff-Parkinson White Syndrome and Ectopic Foci Causing Tachydysrhythmias in Children. Am Heart J 1987;82-792.

PMID: 3310564

2. Keller BB, Hu N and Clark EB: Correlation of Ventricular Area, Perimeter, and Conotruncal Diameter with Mass and

Function in the Stage 12 to 24 Chick Embryo. Circ Res 1990;66:109-14. PMID: 2295133

3. Keller BB, Hu N, Serrino PJ, and Clark EB: Ventricular Pressure-Area Loop Characteristics in the Stage 16 to 24 Chick

Embryo. Circ Res 1991;68:226-231. PMID: 1984865

4. Campbell KA, Hu N, Clark EB, and Keller BB: Analysis of dynamic atrial dimension and function during early cardiac

development in the chick embryo. Ped Res 1992;32:333-337. PMID: 1408472

5. Carstensen EL, Duck FA, Meltzer RS, Schwarz KQ, and Keller BB: Bioeffects in echocardiography. Echocardiography

1992;6:605-623. PMID: 10147799

6. Taber LA, Hu N, Pexieder T, Clark EB and Keller BB: Residual strain in the embryonic ventricle of the stage 16 to 24 chick

embryo heart. Circ Res 1993;72:455-462. PMID: 8418994

7. Keller BB, Hu N, and Tinney JP: Embryonic ventricular diastolic and systolic pressure-volume relation. Cardiology in the

Young 1994,4:19-27

8. Casillas CB, Tinney JP, and Keller BB: Influence of acute alterations in cycle length on ventricular function in the chick

embryo. Am J Physiol 1994;267:H905-911. PMID: 8092294

9. Taber LA, Sun H, Cartmell JS, Clark EB, and Keller BB: Epicardial strains in the stage 16 - 24 embryonic chick ventricle.

Circ Res 1994;75:896-903. PMID: 7923636

10. Hu N, Hansen AL, Clark EB, and Keller BB: Atrial natriuretic peptide reduces diastolic filling in the stage 21 chick embryo.

Ped Res 1995;37:465-468. PMID: 7596686

11. Hu N and Keller BB: Relationship of simultaneous atrial and ventricular pressures in the stage 16 to 27 chick embryo. Am J

Physiol 1995;269:H1359-H1362. PMID: 7485568

12. Bowers PN, Tinney JP, and Keller BB: Nitroprusside selectively reduces ventricular preload in the stage 21 chick embryo.

Cardiovasc Res 1996;31:E132-E138. PMID: 8681337

13. Yoshigi M, Hu N, and Keller BB: Dorsal aortic impedance in the stage 24 chick embryo following acute changes in

circulating blood volume. Am J Physiol 1996;270:H1597-1606. PMID: 8928864

14. Keller BB, MacLennan MJ, Tinney JP, and Yoshigi M: In vivo assessment of embryonic cardiovascular dimensions and

function in day 10.5 To 14.5 mouse embryos. Circ Res 1996;79:247-255. PMID: 8756001

15. Yoshigi M and Keller BB: Linearity of pulsatile pressure–flow relations in the embryonic chick vascular system. Circ Res

1996;79:864-870. PMID: 8831512

16. Yoshigi M and Keller BB: Characterization of the embryonic aortic impedance with lumped parameter models. Am J Physiol

1997;273:H19-H27. PMID: 9249470

17. Babbitt K, Fuller L, and Keller BB: A surface micromachined capacitive pressure sensor for biomedical applications. IEEE

Proceedings #97CH36030, Twelfth Biennial University/Government/Industry Microeletronics Symposium 1997;150-153.

18. Miller CE, Vanni MA, Taber LA, and Keller BB: Passive stress-strain measurements in the stage 16 and stage 18 embryonic

chick heart. JBME 1997;119:445-451. PMID: 9407284



ARTICLES (first or senior author, continued) 19. Miller CE, Vanni MA, and Keller BB: Characterization of passive embryonic myocardium by quasi-linear viscoelasticity

theory. J Biomech 1997;30:985-988. PMID: 9302625

20. Yoshigi M, Ettel JM, and Keller BB: Developmental changes in flow wave propagation velocity in the embryonic chick

vascular system. Am J Physiol 1997;273:H1523-H1529. PMID: 9321845

21. Keller BB, Yoshigi M, and Tinney JP: Ventricular-vascular uncoupling by acute conotruncal occlusion in the stage 21 chick

embryo. Am J Physiol 1997;273:H2861-H2866. PMID: 9435625

22. Tsyvian PB, Routkevich SM, Protsenko YL, Tsyvian EP, Miller CE, and Keller BB: The role of the intra- and extracellular

sources in “Force-Frequency” relations in the chick embryonic myocardium. Russian J Physiol 1998;84:1402-1411.

23. Furukawa S, MacLennan MJ, and Keller BB: Hemodynamic response to anesthesia in pregnant and nonpregnant ICR mice.

Lab Animal Sci 1998;48:357-363. PMID: 10090043

24. Solovyeva OE, Markhasin VS, Tsyvian PB, and Keller BB: Experimental and theoretical investigation of force-interval

relationships in the developing chick myocardium. Biophysica (Ru) 1999;44:337-349.

25. MacLennan MJ and Keller BB: Murine embryonic umbilical arterial velocity during development and following acutely

increased heart rate. Ultrasound in Med Biol 1999;25:361-370. PMID: 10374980

26. Tobita K and Keller BB: End-systolic myocardial stiffness is a load independent index of contractility in the stage 24 chick

embryonic heart. Am J Physiol 1999;276:H2101-H2108. PMID: 10362693

27. Yoshigi M, Keller BB. Pressure-volume relationships of the embryonic heart analyzed by custom-developed IMAQ image

analysis system [Japanese]. InterLab. 1999;4:58-59.

28. Tobita K and Keller BB: Maturation of end-systolic stress-strain relations in chick embryo myocardium. Am J Physiol

2000;279:H216-H224. PMID: 10899059

29. Yoshigi M, Knott G, and Keller BB: Lumped parameter estimation for the embryonic chick vascular system: a time domain

approach using MLAB. Computer Programs Biomed J 2000;63(1):29-41. PMID: 10927152

30. Tobita K and Keller BB: Ventricular epicardial deformation patterns during normal development and during the development

of left heart hypoplasia in the chick embryo. Am J Physiol 2000;279:H959-H969. PMID: 10993756

31. Tsyvian PB, MarkhasinVS, Solovyeva OE, Rutkevitch SM, Protsenko LL, Artemeva OG, Schroder EA, and Keller BB:

Contraction-relaxation dynamics and mechanical restitution in the developing myocardium of the chick embryo. Rossiiskii

Fiziologicheskii Zhurnal Imeni I.M. Sechenova Rossiiskaia Akademiia Nauk. 2001;87:901-910. PMID: 11575123

32. Tobita K, Schroder EA, Tinney JP, Garrison JB, and Keller BB: Regional passive ventricular pressure-strain relations during

development of altered loads in the chick embryo. Am J Physiol 2002;282:H2386-H2396. PMID: 12003850

33. Schroder EA, Tobita K, Tinney JP, and Keller BB: Microtubule involvement in the adaptation to altered mechanical load in

the developing chick myocardium. Circ Res 2002;91:353-359. PMID: 12193469

34. Markhasin VS, Nikitina LV, Routkevich SM, Katsnelson LB, Schroder EA, and Keller BB: Effects of mechanical interaction

between two rabbit cardiac muscles connected in parallel. J Gen Physiol 2002;21:277-301. PMID: 12537352

35. Tobita K, Garrison JB, Liu LJ, Tinney JP, and Keller BB: Three dimensional myofiber architecture of the embryonic left

ventricle during normal and development of altered mechanical loads. Anat Rec A Discov Mol Cell Evol Biol

2005;283(1):193-201. PMID: 15678488



ARTICLES (first or senior author, continued) 36. Lucitti JL, Tobita K, and Keller BB: Arterial hemodynamics and mechanical properties after circulatory intervention in the

chick embryo. J Exp Biol 2005;208(10):1877-1885. PMID: 15879068

37. Sharma SK, Lucitti JL, Nordman C, Tinney JP, Tobita K, and Keller BB: Impact of Hypoxia on Early Chick Embryo

Growth and Cardiovascular Function. Pediatr Res 2005;58(4):818-824. PMID: 16327005

38. Manole MD, Hickey RW, Momoi N, Tobita K, Tinney JP, Suciu GP, Johnnides M, Clark RS, and Keller BB: Preterminal

gasping during anoxic arrest increases cardiac function in immature rats. Pediatr Res 2006;60(2):174-179. PMID: 16864699

39. Tobita K, Liu LJ, Janczewski AM, Tinney JP, Nonemaker JM, Augustine S, Stolz DB, Shroff SG, and Keller BB:

Engineered early embryonic cardiac tissue (EEECT) retains proliferative and contractile properties of developing embryonic

myocardium. Am J Physiol Heart Circ Physiol 2006;291(4):H1829-H1837. PMID: 16617136

40. Lucitti JL, Visconti R, Novak J, and Keller BB: Increased arterial load alters aortic structural and functional properties

during embryogenesis. Am J Physiol Heart Circ Physiol 2006;291(4):H1919-H1926. PMID: 16648183

41. Furukawa S, Tinney JP, Tobita K, and Keller BB: Hemodynamic vulnerability to acute hypoxia in day 10.5 to 16.5 murine

embryos. J Obstet Gynecol Res 2006;33:114-127. PMID: 17441882

42. Keller BB, Liu LJ, Tinney JP, and Tobita K. Cardiovascular developmental insights from embryos. Ann NY Acad Sci

2007;100:1399-1401. PMID: 17303838

43. Emery SP, Kreutzer J, Sherman FR, Fujimoto KL, Jaramaz B, Nikou C, Tobita K, and Keller BB. Computer-assisted

navigation applied to fetal cardiac intervention. Int J Med Rob Comp Asst Surg 2007;3(3):187-198. PMID: 17729376

44. Emery SP, Kreutzer J, McCaffrey F, Sherman FR, Simhan HN, and Keller BB. The learning curve of a fetal cardiac

intervention team. Min Invasive Surg 2010;2010:674185. PMID 22091354

45. Das BB, Christensen J, Brock G, Barnes C, Sobczyk W, and Keller BB. Compaction ratio guidelines in the diagnosis of

isolated left ventricular noncompaction in infants and children. J Kentucky Medical Assoc 2011 (in press)

46. Ralphe JC, Tobita K, Witt MR, Kirk J, DeLange WJ, and Keller BB. Modeling the immature heart: contractile

performance and calcium transients in neonatal rat 3D engineered cardiac tissue. Pediatr Res (in revision).

47. Downs-Canner S, Ng L, Peng D, Keller JM, Nakanishi T, Gu H, Keller BB. Change in oxygen saturation in response to

exercise as a screening method to detect congenital heart disease in remote, rural Tibetan children, J Pediatrics (in

preparation).



ARTICLES (contributing author) 1. Hu N, Connuck D, Keller BB, and Clark EB: Passive and active diastolic ventricular function in stage 12 to 27 chick embryos.

Ped Res 1991;29:334-337. PMID: 1852525

2. Dalecki D, Keller BB, Carstensen EL, Neel DS, Palladino JL, Noordergraaf A: Thresholds for premature ventricular

contractions caused by lithotripter shocks. Ultrasound Med Biol 1991;17:341-346. PMID: 1719683

3. Taber LA, Keller BB, and Clark EB: Cardiac mechanics in the stage 16 chick embryo. J Biomech Eng 1992;114:427-434.

PMID: 1487893

4. Dalecki D, Keller BB, Raeman CH, and Carstensen EL: Effects of pulsed ultrasound on the frog heart: I. Thresholds for

changes in cardiac rhythm and aortic pressure. J Ultrasound Med Biology 1993;19:385-390. PMID: 8356782

5. Ursem NTC, Brinkman HJF, Struijk PC, Hop WCJ, Kempski MH, Keller BB, and Wladimiroff JW. Umbilical artery

waveform analysis based on maximum, mean, and mode velocity in early human pregnancy. Ultrasound Med Biol 1998;24:1-

7. PMID: 9483765

6. Ursem NTC, Struijk PC, Hop WCJ, Clark EB, Keller BB, and Wladimiroff JW. Heart rate and flow velocity variability as

determined from umbilical doppler velocimetry at 10-20 weeks of gestation. Clinical Science 1998;95:539-545. PMID:

9791039

7. Ursem NTC, Clark EB, Keller BB, and Wladimiroff JW. Fetal heart rate and umbilical artery velocity variability in pregnancies

complicated by insulin-dependent diabetes mellitus. Ultrasound Obstet Gynecol 1999;13:312-6. PMID: 10380294

8. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Do heart rate and velocity variability derived from

umbilical artery velocity waveforms change prior to clinical pregnancy induced hypertension? Ultrasound Obstet Gynecol

1999;14:244-9. PMID: 10586475

9. Ursem NTC, Clark EB, Keller BB, Hop WCJ and Wladimiroff JW. Assessment of fetal heart rate and velocity variability by

Doppler velocimetry of the descending aorta at 10-20 weeks of gestation. Ultrasound Obstet Gynecol 1999 14:397-401.

PMID: 10658278

10. Cribbs LL, Schroder EA, Keller BB, Delisle BP, and Satin J. Identification of the CaV3.1d gene product in developing

mouse heart: A contributor to embryonic contractility. Circ Res 2001;88:403-407. PMID: 11230107

11. Struijk PC, Ursem NTC, Mathews J, Clark EB, Keller BB , and Wladimiroff JW. Power spectrum analysis of heart rate and

blood flow velocity variability in the umbilical artery and uterine artery in early pregnancy. A comparative study.

Ultrasound Obstet Gynecol 2001;17:316-321. PMID: 11339188

12. Sedmera D, Hu N, Weiss KM, Keller BB, Denslow S, and Thompson RP. Cellular changes in experimental left heart

hypoplasia. Anat Rec 2002;267:137-145. PMID: 11997882

13. Chalothorn D, McCune DF, Edelmann SE, Tobita K, Keller BB, Lasley RD, Perez DM, Tanoue A, Tsujimoto G, Post GR,

and Piascik MT: Differential Cardiovascular Regulatory Activities of the Alpha1B- and Alpha1D-Adrenoceptor Subtypes. J

Phamacol Exp Ther 2003;305:1045-1053. PMID: 12649302

14. Jeffries JL, Noonan JA, Keller BB, Wilson JF, and Griffith C III: Quality of life and social outcomes in rural adults with

congenital heart disease. Am J Cardiol 2004;94:263-266. PMID: 15246920

15. Law YM, Feingold BM, Keller BB, and Boyle GJ: Use of Plasma B-type Natriuretic Peptide to Identify Ventricular

Dysfunction in Pediatric and Adult Congenital Heart Disease Patients. Am J Cardiol 2005;95:474-478. PMID: 15695131

16. Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, and Huard J:

Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Therapy 2005;12(6):1130-1141.

PMID: 16125468



ARTICLES (contributing author, continued) 17. Wearden P, Morell V, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos R, Kameneva MV, Simaan

M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B,

Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, and Shaddy RE. The

PediaFlowTM

Pediatric Ventricular Assist Device. Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac

Surgery Annual 2006. (ed) Richard A. Jonas, pp. 92 – 98. PMID: 16638553

18. Borovetz HS, Badylak S, Boston JR, Johnson C, Kormos R, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner

WR, Woolley J, Antaki J, Diao C, Candenberghe S, Keller B, Morell V, Wearden P, Webber S, Gardiner J, Li CM, Paden

D, Paden B, Snyder S, Wu J, Bearnson G, Hawkins JA, Jacobs G, Kirk J, Khanwilkar P, Kouretas PC, Long J, and Shaddy

RE. Towards the development of a pediatric ventricular assist device. Cell Transplantation 2006;15:S69-S74. PMID:

16826798

19. Fujimoto KL, Tobita K, Merryman DW, Guan J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR. An elastic,

biodegradable cardiac patch induces contractile smooth muscle and prevents cardiac remodeling in sub-acute myocardial

infarction. JACC 2007;49(23):2292-300. PMID: 17560295

20. Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller BB, Peng H, Huard J: A relationship between vascular

endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts.

JACC 2007;50:1677-1684. PMID: 17950150

21. Pekkan K, Dasi LP, Nourparvar P, Yerneni S, Tobita K, Fogel M, Keller BB, Yoganathan A: In Vitro hemodynamic

investigation of the embryonic aortic arch at late gestation. J Biomechanics 2008;41(8):1697-1706. PMID: 18466908

22. Momoi N, Tinney JP, Liu LJ, Elshershari H, Hoffman PJ, Ralphe JC, Keller BB, Tobita K: Modest maternal caffeine

exposure affects developing embryonic cardiovascular function and growth. Am J Physiol Heart Cir 2008;294(5):H2248-

56. PMID: 18359892

23. Zahka K, Kalidas K, Cross H, Humbush J, Keller B, Galambos C, Gurtz K, Patton MA, Crosby AH. Homozygous

mutation of MYBPC3 associated with severe infantile hypertrophic cardiomyopathy at high frequency amongst the Amish.

Heart 2008;94(10):1326-30. PMID: 18467358

24. Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Phillippi JA, Peault B, Huard J:Myogenic

endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted

myocardium. JACC 2008;52:1869-1880. PMID: 19038685

25. Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney

JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. The role of cardiac

troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS ONE. 2008 Jul 9;3(7):e2642.

PMID: 18612386

26. Park TS, Zambidis ET, Lucitti JL, Logar A, Keller BB, Péault B. , Human embryonic stem cell-derived hematoendothelial

progenitors efficiently engraft chicken embryos. Exp Hematol 2009;37(1):31-41. PMID: 17560295

27. Urish KL, Vella JB, Okada M, Deasy BM, Tobita K, Keller BB, Cao B, Piganelli JD, Huard J. Antioxidant levels

represent a major determinant in the regenerative capacity of muscle stem cells. Mol Biol Cell 2009;20(1):509-20. PMID:

19005220

28. Clause KC, Tinney JP, Liu LJ, Keller BB, Tobita K. Engineered early embryonic cardiac tissue increases cardiomyocyte

proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Eng Part A 2009;12(6):1373-80.

PMID: 19196150

29. Wang Y, Dur O, Patrick MJ, Tinney JP, Tobita K, Keller BB, and Pekkan K. Aortic arch morphogenesis and flow

modeling in the chick embryo. Ann Biomed Eng 2009:37(6):1069-81. PMID: 19337838



ARTICLES (contributing author, continued) 30. Fujimoto KL, Miki T, Liu LJ, Hashizume R, Strom SC, Wagner W, Keller BB, Tobita K: Naive rate amnion-derived cell

transplantation improved left ventricular function and reduced myocardial scar of post-infarcted heart. Cell Transplantation

2009;18(4):477-86. PMID: 19622235

31. Drowley L, Okada M, Payne T, Botta G, Oshima H, Keller BB, Tobita K, Huard J. Sex of muscle stem cells does not

influence potency for cardiac cell therapy. Cell Transplantation 2009;18(10):1137-1146 PMID: 19523348

32. Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller

BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle derived

stem cells. Tissue Eng Part C Methods 2010;16(3):375-85. PMID: 19601695

33. Dur O, Lara M, Arnold D, Vandenberghe S, Keller BB, DeGroff K, Pekkan K. Pulsatile in vitro simulation of the pediatric

univentricular circulation for evaluation of cardiopulmonary assist scenarios. Artif Organs 2009;33:967-976. PMID:

20021470

34. Dur O, DeGroff CG, Keller BB, Pekkan K. Optimization of inflow waveform phase-difference for minimized total

cavopulmonary power loss. J Biomed Eng 2010;132:031012. PMID: 20459200

35. Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, Keller BB, Sacks MS, Wagner WR. Morphological

and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable

polyurethane elastomer scaffold. Biomaterials 2010;31:3253-65. PMID: 20138661

36. Drowley L, Okada M, Beckman S, Vella J, Keller BB, Tobita K, Huard J. Cellular antioxidant levels influence muscle

stem cell therapy. Mol Therapy 2010;18(10):1865-7. PMID: 20664528

37. Abdulkadir AA, Tobita K, Bell MJ, Macpherson TA, Keller BB, Yanowitz TD. Placental maturation and fetal

hemodynamics in a rat model of chorioamnionitis. Ped Res 2010; 68(6):513-518 PMID: 20736882

38. Fujimoto K, Clause KC, Tinney JP, Verma S, Wagner W, Keller BB, Tobita K. Engineered fetal cardiac graft preserves

its cardiomyoctye proliferation within post-infarcted myocardium and sustains cardiac function. Tissue Eng Par A 2011

17:585-96 PMID: 20868205

39. Okada M, Payne TR, Drowley L, Janowski RJ, Momoi N, Beckman S, Chen WCW, Keller BB, Tobita K, Huard J:

Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of

ischemic hearts. Molecular Therapy 2012;20(1):138-145 PMID: 22068427

40. Cassino TR, Drowley L, Okada M, Keller BB, Tobita K, LeDuc PR, and Huard J. The use of mechanical preconditioning

on the regenerative potential of stem cells. Tissue Engineering Part A 2011 (in press)

41. Kowalski WJ, Teslovich NC, Dur O, Keller BB, Pekkan K. Computational hemodynamic optimization predicts dominant

aortic arch selection is driven by embryonic outflow tract orientation in the chick embryo. Biomech Modeling in

Mechanobiology –BMMB 2012 (in press).

42. Momoi N, Tinney JP, Keller BB, Tobita K: Maternal hypoxia and caffeine exposure depress fetal cardiovascular function

during primary organogenesis. JOGR 2012 (in press)

43. Clause KC, Tchao JS, Powell MC, Liu LJ, Huard J, Keller BB, Tobita K. Developing cardiac and skeletal muscle share

fast-skeletal myosin heavy chain and cardiac troponin-I expression. PLoS ONE (in revision)

44. Wang Y, Ferreira A, Vandenberghe S, Mano A, Keller BB, Gorcsan J, Antaki JF. Simulation of mechanical circulatory

support with unimodal elastance model for optimal ventricular energetics. (in preparation)

PATIENT EDUCATIONAL MATERIALS 1. Solinger R and Keller BB (eds). Congenital Heart Disease Health Maintenance Information Guide. Chapter: Coarctation of

the Aorta (CoA) (in preparation)



P. LECTURES Date Title and Institution

October, 1989 Ventricular Mechanics in the Chick Embryo, Children's Memorial Hospital, Chicago, IL.

March, 1990 Diagnosis and Management of Heart Failure in Children, Pediatric Grand Rounds, Belle Glade, FL.

September, 1990 Ventricular Mechanics in the Developing Heart, Strong Children's Research Center, Rochester, NY.

July, 1991 Biomechanics of the Developing Cardiovascular System, Japan Heart Institute, Tokyo Women's

Medical College, Tokyo, Japan.

September, 1991 Embryonic and Fetal Cardiovascular Mechanics. Northeast Ped. Cardiology Society, Hyannis, MA

August, 1992 Fetal Cardiovascular Screening. Grand Rounds, Department of Obstetrics and Gynecology, The

Genesee Hospital, Rochester, NY.

June, 1993 Embryonic Cardiovascular Structural and Functional Maturation, Complutense University, Madrid,

SPAIN.

November, 1993 Cardiovascular Structural and Functional Maturation. University of South Carolina, Columbia, SC.

November, 1993 Embryonic Integrated Physiology, Engineering, and Mechanics. Kyoto Prefectural University, Kyoto,

JAPAN.

January, 1994 Tetralogy of Fallot: An Example of Congenital Heart Disease in Evolution. Grand Rounds, Dept of

Pediatrics, University of Rochester, Rochester, NY

May, 1994 Tetralogy of Fallot: Clinical and Basic Science Advances. 75 annual meeting of the Central New

York

Pediatric Club, New Hartford, NY.

November, 1994 Embryonic Cardiovascular Maturation. Burgher Cardiovascular Institute. UCSD, La Jolla, CA.

November, 1994 Embryonic Structural and Functional Maturation. Spontaneous Comparative Physiology Workshop,

UNLV, Las Vegas, NV

December, 1994 Cardiac Developmental and Mechanical Forces. NIH SCOR in Neonatology, Department of

Pediatrics, University of Rochester, NY.

August, 1995 Avian and Mammalian Embryonic Cardiovascular Function. Perinatal Cardiology Conference,

Pennsylvania Hospital, Philadelphia, PA.

August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Perinatal Management

Conference, Pennsylvania Hospital, Philadelphia, PA.

August, 1995 Normal and Experimentally Altered Embryonic Cardiovascular Function. Dept of Cell Biology, Univ.

Med. and Dent. of New Jersey, Stratford, NJ.

October, 1995 Cardiovascular Embryology and Physiology. Fetal Echocardiography Program. The Jefferson

Feb and Sept, 1996 Ultrasound Research and Education Institute and Pennsylvania Hospital, Philadelphia, PA.

Feb and Oct, 1997

March, 1996 Novel Approaches in the Experimental Investigation of Cardiovascular Development: Chick, Mouse,

and Human. Reproductive/Development Workshop, University of Rochester.

April, 1996 Tetralogy of Fallot: Past, Present, and Future Challenges. Cardiology Update 1996, American Heart

Association Long Island Affiliate, Mineola, NY.



LECTURES (continued) October, 1996 Physiologic and Engineering Investigation of Cardiovascular Development. Ural Branch, Russian

Academy of Science, Yekaterinburg, Russia.

January, 1997 Tetralogy of Fallot -From Bench to Bedside. Department of Pediatrics Grand Rounds, New York

University Medical Center, New York, NY.

January, 1997 Embryonic Cardiovascular Physiology, Evolving Strategies. Department of Pediatrics, Division of

Pediatric Cardiology, NYU Medical Center, New York.

March, 1997 Cardiovascular Physiology and Mechanics in the Embryo. Department of Cell Biology and Anatomy,

Medical University of South Carolina, Charleston, SC.

April, 1997 Tetralogy of Fallot - At the Leading Edge. Department of Pediatrics Grand Rounds, New York

Medical College, Valhalla, NY.

April, 1997 Physiology and Mechanics of the Developing Myocardium. Physiology Department Grand Rounds,

New York Medical College, Valhalla, NY.

July, 1997 Physiology and Mechanics in the Developing Cardiovascular System. Departments of Pediatrics,

Rainbow Babies Childrens Hospital, Cleveland, OH.

February, 1998 Congenital Cardiovascular Malformations: New Ideas About Old Problems. Regional Mother and

Child Hospital, Yekaterinburg, Siberia, Russia.

March, 1998 Integrated Embryonic Cardiovascular Physiology and Mechanics, Japan Heart Institute, Tokyo

Women's Medical College, Tokyo, Japan.

April, 1998 Tetralogy of Fallot - Bedside to Bench. Department of Pediatrics Grand Rounds, State Univ. of New

York, Winthrope Univ Hospital, Mineola, NY

June, 1998 Dysrhythmias in the Newborn. 18th Annual Townsend Teaching Day in Neonatal/Perinatal Medicine,

Rochester General Hospital, Rochester, NY.

October, 1998 Approaches to Mend the Broken Heart. Department of Pediatrics Grand Rounds. University of

Kentucky, Lexington, KY.

January, 1999 Function, Biomechanics and Control of Developing Cardiovascular Systems. University of Arizona,

Department of Biomedical Engineering, Tucson, AZ.

March, 1999 Function and Biomechanics of the Developing Heart. Department of Physiology Lecture Series.

University of Kentucky, Lexington, KY..

April, 1999 Congenital Heart Disease in Adulthood. 2nd

Coronary Valley Symposium, Raddison Hotel, Lexington,

KY.

April, 1999 Function and Biomechanics of the Developing Cardiovascular System. Bioengineering Program

Lecture Series, University of Kentucky, Lexington, KY.

April, 1999 Pediatric Cardiology Update. Department of Pediatrics, Central Baptist Hospital, Lexington, KY.

May, 1999 Common Pediatric Cardiology Dilemmas, Contemporary Pediatrics for the Practicing Physician

Conference, Lexington, KY.

October, 1999 News from the First Noonan Congenital Cardiovascular Symposium, Department of Pediatrics Grand

Rounds. University of Kentucky, Lexington, KY.



LECTURES (continued) November, 1999 Cardiovascular Screening of the Young Athlete. First Annual Pikeville College School of Osteopathic

Medicine Pediatric Symposium, Pikeville, KY.

November, 1999 Basic Approaches in Ambulatory Pediatric Cardiology. Lake Cumberland Regional Nursing

Continuing Medical Education Conference, Somerset, KY.

December, 1999 Embryonic Cardiovascular Structure-Function Paradigms: Insights into Normal Development and

Congenital Cardiovascular Malformations. Samuel Lunenfeld Research Institute, University of

Toronto, Canada.

March, 2000 Clinical and Basic Science Advances in Congenital Heart Disease, Department of Emergency

Medicine Grand Rounds, Lexington, KY.

May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The Institute for Child Health,

Great Ormond Street, London, England.

May, 2000 Structure-Function Paradigms in Developing Cardiovascular Systems. The National Heart and Lung

Institute at the Brompton Hospital, London, England.

January, 2001 Profiles in Aortic Valve Disease: Natural and Unnatural Histories. Department of Pediatrics Grand

Rounds. University of Kentucky, Lexington, KY.

June, 2001 New Horizons in Pediatric Cardiovascular Diseases for the 21st Century. New Horizons in Fetal

Cardiology. The National Heart and Lung Institute at the Brompton Hospital, London.

October, 2001 Structure, Function, and Adaptation of Developing Cardiovascular Systems: Insights from Embryos.

University of Pittsburgh, Pittsburgh, PA.

January, 2002 Basic Approaches to the Spectrum of Pediatric Arrhythmias. Department of Pediatrics Grand Rounds.

University of Kentucky, Lexington, KY.

January, 2002 Insights into Cardiovascular Malformations Learned from the Embryo. Gill Cardiovascular Research

Symposium, University of Kentucky, Lexington, KY.

December, 2002 Physiology and Biomechanics of Developing Cardiovascular Systems from Embryo to Adult.

Department of Pediatric Cardiology, Kyoto Prefectural University, Kyoto, JAPAN.

January, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: From Embryo to Adult.

Department of Pediatrics Research Conference, Children’s Hospital of Pittsburgh, Pittsburgh, PA.

April, 2003 Physiology and Biomechanics of Developing Cardiovascular Systems: Research Overview.

Magowan Institute of Regenerative Medicine Seminar Series, University of Pittsburgh, Pittsburgh, PA.

June, 2003 Innovations in the Diagnosis and Management of Congenital Heart Disease. Department of Pediatrics

Grand Rounds, Children’s Hospital of Pittsburgh, Pittsburgh, PA

March 2004 Fetal Cardiovascular Malformations: Novel Approaches to Pathogenesis and Intervention.

Department of Obstetrics and Gynecology Grand Rounds, Magee Womens Research Institute,

Pittsburgh, PA

March 2004 Congenital Cardiovascular Malformations in Adults - the Developmental Perspective. Cardiovascular

Institute Grand Rounds, Department of Medicine, University of Pittsburgh, Pittsburgh, PA



LECTURES (continued) April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part I – Developmental

Mechanisms. 3rd

Five-Continent International Symposium on Cardiovascular Diseases and 20th

Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China

April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult: Part II – Clinical

Applications. 3rd

Five-Continent International Symposium on Cardiovascular Diseases and 20th

Anniversary Celebration of the Founding of Anzhen Hospital, Beijing, China

April 2004 Congenital Heart Disease: Novel Approaches from the Fetus to the Adult. Department of Pediatric

Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

March 2005 Physiology and Biomechanics of Developing Cardiovascular Systems: Insights from Embryos.

Department of Pediatrics Combined Allergy/Immunology Conference, Children’s Hospital of

Pittsburgh, Pittsburgh, PA

October 2005 Evolution in the Assessment of Embryonic Ventricular Function. Department of Obstetrics and

Gynecology, Erasmus University, Rotterdam, the Netherlands

March 2007 Insights From Embryos on Cardiovascular Morphogenesis, Adaptation, and Repair. University of

Pittsburgh Graduate School of Public Health, Department of Environmental and Occupational Health,


April 2007 Mending the Broken Embryonic Heart. 2007 Annual Science Lecturer. Heart Research Center.

Oregon Health & Science University, Portland, OR

April 2007 Genetic Mechanism of Congenital Cardiovascular Malformations. Fellow’s Conference. Division of

Pediatric Cardiology, Department of Pediatrics. Oregon Health & Science University, Portland, OR

June 2007 Update on Maternal-Embryonic Cardiovascular Coupling. Samuel Lunenfeld Research Institute,

University of Toronto, Canada.

February 2008 Insights from Embryos on How to Repair a Broken Heart. Department of Pediatrics. Yale School of

Medicine, Yale New Haven Children’s Hospital, New Haven, CT.

April 2008 Congenital Heart Disease: Engineering Challenges and Opportunities. Surgery for Engineers

Course, Carnegie Mellon University, Pittsburgh, PA.

January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Neonatology

Grand Rounds. Magee-Women’s Hospital of UPMC, Pittsburgh, PA.

January 2009 Molecular Biology and Bioengineering Insights into How to Repair a Broken Heart. Department of

Pediatrics, Golisano Children’s Hospital at Strong, University of Rochester, Rochester, NY

October 9, 2009 Pediatric Cardiology in Emerging Nations. 7th

Annual Cardiovascular Diseases and Stroke

Symposium. Louisville, KY

October 30, 2009 Insights into the Causes and Consequences of Congenital Heart Disease. Annual Cardiovascular

Symposium. Kings Daughters Heart and Vascular Center, Ashland, KY.

April 9, 2010 Insights into the Causes and Treatments of Congenital Heart Disease with an Update on High

Resolution Ultrasound Imaging for Humans. Christine M. Kleinert Institute for Hand and

Microsurgery, Louisville, KY

July 8, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department of

Pharmacology and Toxicology, University of Louisville, Louisville, KY



LECTURES (continued)

October 19, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Frontier

Lifeline Hospital and the K.M. Cherrian Heart Foundation, Chennai, India

November 5, 2010 Insights from Embryos into Cardiac Morphogenesis and Repair. 2010 Carolina Cardiovascular

COBRE Conference, University of South Carolina, Columbia, SC

December 13, 2010 Insights from Embryos into the Causes and Treatments of Congenital Heart Disease. Department

of Pediatrics, University of Louisville, Louisville, KY

March 14, 2010 Asking and Answering Pediatric Relevant Research Questions. Department of Pediatrics, University

of Louisville, Louisville, KY

April 14, 2011 Insights from Embryos into Cardiac Morphogenesis and Repair. 9th Annual Spring Symposium of

the Cardiovascular Developmental Biology Center (CDBC): Formation and Remodeling of the

Cardiovascular System in Health and Disease. Medical University of South Carolina, Charleston,SC

September 10, 2011 Expanding our Understanding and Treatment of Heart Disease in Children. Kosair Charities Annual

Luncheon, Louisville, KY

Curriculum Vitae -- Bradley B. Keller,...

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