CURRICULUM VITAE

WAYNE M. YOKOYAMA

DATE: November 29, 2013 1. PERSONAL INFORMATION: a. Sex: Male b. Date of Birth: July 1, 1952 c. Place of Birth: Wailuku, Maui, Hawaii 2. CITIZENSHIP: USA 3. ADDRESSES AND TELEPHONE NUMBERS: Office and Lab: Howard Hughes Medical Institute Rheumatology Division, Box 8045 Department of Medicine Washington University School of Medicine 660 South Euclid Avenue St. Louis, MO 63110 Telephone: (314) 362-9075 FAX: (314) 362-9257 E-mail Address: yokoyama@dom.wustl.edu Home: 9908 Old Warson Road St. Louis, MO 63124 Telephone: (314) 984-0148 4. PRESENT POSITIONS: Howard Hughes Medical Institute (HHMI) 1997-Date Investigator Washington University School of Medicine (WUSM), St. Louis, MO 1995-Date Professor of Medicine (with tenure) and Professor of Pathology and Immunology 1995-Date Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis 2007-Date Director, Medical Scientist Training Program (MSTP; M.D.-Ph.D. program, largest in U.S. with ~200 students) 5. EDUCATION: a. Undergraduate: 1974 B.A. (Biology), University of Rochester, Rochester, NY b. Graduate: 1978 M.D., University of Hawaii at Manoa, Honolulu, Hawaii c. Postgraduate Clinical Training: 1978-1979 Intern, Internal Medicine, University of Iowa Hospitals, Iowa City, IA 1979-1981 Resident, Internal Medicine, University of Iowa Hospitals 1981-1982 Clinical Fellow, Rheumatology, University of Iowa Hospitals d. Pre- and Post-graduate Basic Research Training: 1969, 1972 Summer research fellow, Laboratory of Dr. M. Mitsuo Yokoyama (no relation), Kuakini Medical Research Institute, Honolulu, HI

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1971-1974 Student researcher (school years, 1973, 1974 summers), Laboratory of Dr. Parker Staples, Division of Allergy and Immunology, Department of Medicine, University of Rochester School of Medicine, Rochester, NY 1975-1976 Student researcher, Laboratory of Dr. Eugene Lance, Cancer Center of Hawaii, Honolulu 1982-1985 Research Fellow, Laboratory of Dr. Robert F. Ashman, Rheumatology Division, Department of Medicine, University of Iowa Hospitals 1985-1989 Research Fellow, Laboratory of Dr. Ethan M. Shevach, Laboratory of Immunology, NIAID, NIH, Bethesda, MD 6. PREVIOUS ACADEMIC POSITIONS/EMPLOYMENT: 1989-1992 Assistant Professor in Residence, Rheumatology Division, Department of Medicine, School of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 1992-1995 Associate Professor, Division of Molecular Medicine, Department of Medicine, Mount Sinai Medical Center (MSSM), New York, NY 1992-1995 Associate Professor, Brookdale Center for Molecular Biology, MSSM 1994-1995 Associate Professor, Department of Microbiology, MSSM 1994-1995 Associate Investigator, HHMI (Voluntary resignation to accept WUSM position) 1995-2007 Chief, Rheumatology Division, Department of Medicine, WUSM 7. UNIVERSITY AND HOSPITAL APPOINTMENTS AND COMMITTEES:

Hospital Appointments: 1982-1985 Attending Staff Physician, Rheumatology Division, Department of Internal Medicine, University of Iowa Hospitals, Iowa City, IA 1989-1992 Attending Physician, Rheumatology Division, The Medical Service, San Francisco General Hospital, San Francisco, CA 1992-1995 Associate Attending Physician, Department of Medicine, MSSM 1995-Date Attending Physician, Department of Medicine, Barnes-Jewish Hospital, St. Louis, MO 1996-2008 Consultant, Department of Medicine, John Cochran Veteran’s Administration Medical Center, St. Louis, MO

Department Service: 1992-1995 Annual Research Activities Committee, Dept Med, MSSM 1992-1993 Internship Selection Committee, Department of Medicine, MSSM 1992-1993 Laboratory Renovation Committee, Department of Medicine, MSSM 1993-1995 Developer and (first) Director, Research Residency Program, Department of Medicine, MSSM 1997-1999 Promotions Sub-committee, Department of Medicine, WUSM 1998 Research Planning Steering Committee, Dept of Medicine, WUSM Chair, Subcommittee on Research Initiatives, Research Planning Committee, Dept of Med, WUSM Developer, Program in Investigative Medicine, Dept of Med, WUSM Steering Committee, Program in Investigative Medicine 1999 Search Committee for Chief of Division of Infectious Diseases, Dept of Med, WUSM Department Review for HHMI Competition, Dept Med, WUSM 1999-2000 Appointments and Promotions Criteria Committee, Dept Med, WUSM 2002 Applied Genomics Committee, Dept Med, WUSM 2007 Search Committee for Chief of Rheumatology Division, WUSM

Graduate School Service: 1991-1992 Molecular Medicine Program, UCSF 1992 Program in Biological Sciences, UCSF 1992 Immunology Graduate Program, UCSF 1992-1995 Member, Doctoral Faculty, Ph.D. Program in Biomedical Sciences, The Graduate School and University Center of The City University of New York, New York, NY 1994 Ad Hoc Committee on Curricular Development, MSSM 1994 Co-Developer, Multidisciplinary Immunobiology Graduate Program, MSSM 1994-1995 Multidisciplinary Graduate Program in Immunobiology, MSSM 1994-1995 Faculty advisor, Medical Scientist Training Program, MSSM 1994-1995 Ad Hoc Basic Science Professors’ Advisory Committee, MSSM 1995-Date Division of Biology and Biomedical Sciences (DBBS), Washington University

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1995-Date Immunology Graduate Program, DBBS 1996-2007 Steering Committee, Immunology Graduate Program, DBBS 1996-2002 Medical Scientist Training Program Committee, WUSM 1996-2007 Program Committee, Immunology Group Retreat, DBBS 1996-2007 Admissions Committee, Immunology Graduate Program, DBBS 2012-Date Molecular Microbiology and Microbial Pathogenesis Graduate Program, DBBS

School of Medicine Service: 1992-1995 Planning Committee for New Research Building (design of research labs and support), MSSM 1992-1995 Reviewer, Patent Applications, Office of Science & Technology Development, MSSM 1993-1995 Special Grants and Fellowships Review Committee, MSSM 1993-1995 Steering Committee, Research Residency Program, MSSM 1995-2007 Advisory Committee, Center for Immunology, WUSM 1996-2007 Developer and (first) Director, Center for Arthritis and Related Diseases, WUSM 1998 Committee to Assist in the Development of Research and a Course of Study in Rehabilitation Science, WUSM 1998-2000 Strategic Planning Committee, Faculty Practice Plan, WUSM 1998-2000 Clinical Faculty Committee, Faculty Practice Plan, WUSM 1998-Date Siteman Cancer Center, WUSM 1999 HHMI Internal Review Committee, WUSM 2000 Grants Review Committee, HHMI Program, WUSM 2001 Ad hoc reviewer, Human Studies Committee, WUSM 2004-2006 Member, Search Committee for Chairman of Department of Pathology and Immunology 2007-Date Honorary Degree Committee, WUSM 2007-2009 Advisory Committee, Washington University/Pfizer Biomedical Agreement 2009-Date Education Leadership Council, Washington University Medical Center campus 2011-Date Chair, Honorary Degree Committee, WUSM 2011 Internal Scientific Advisory Board, Women’s Reproductive Health Research Career Development Program

University Service: 2001-2003 Chair, Internal Review Committee, Division of Biology and Biomedical Sciences (interdisciplinary graduate program), Graduate School of Arts and Sciences, Washington University 2011-Date University-wide Honorary Degree Committee, Washington University 8. MEDICAL LICENSURE AND BOARD CERTIFICATION:

Licensure: 1979 Iowa (Inactive) 1981 Illinois (Inactive) 1989 California (Inactive) 1992 New York (Inactive) 1996 Missouri

Professional Certification: 1979 National Board of Medical Examiners 1981 American Board of Internal Medicine 1984 Subspecialty Certification in Rheumatology 9. MILITARY SERVICE: None 10. HONORS AND AWARDS: 1969 Hawaii Heart Association Junior Research Summer Fellowship 1970 Hawaii State Science Fair, First Place Rochester Prize Scholarship National Honor Society Scholarship 1974 Hawaii State Medical School Scholarship 1984 Veteran’s Administration Associate Investigator Award

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Arthritis Foundation Postdoctoral Fellowship 1984-1987 Individual NIH National Research Service Award (NRSA) 1987-1988 Medical Staff Fellowship, NIAID, NIH 1988-1989 Senior Staff Fellowship, NIAID, NIH 1989 American Association of Immunologists Travel Award 1989-1992 Scholar of the Rosalind Russell Medical Research Center for Arthritis 1993 Henry Christian Memorial Award for Excellence in Research, AFCR (Outstanding Immunology/Rheumatology Research abstract) 1994 Associate Investigator, Howard Hughes Medical Institute (awarded after national competition, first HHMI appointee at MSSM) 1994 Basic Science Faculty Achievement Award, MSSM Committee of 1000 1995 Sam J. and Audrey Loew Levin Chair for Research on Arthritis, WUSM 1996 American Society for Clinical Investigation (ASCI), elected 1997 Investigator, Howard Hughes Medical Institute (awarded after second national competition) 2000 Association of American Physicians (AAP), elected 2001 Novartis Prize for Basic Research in Immunology (awarded every 3 years at International Congress of Immunology) 2002 Meritorious Extension of Research in Time (MERIT) Award, NIAID, NIH 2006 Research paper (#24 in Bibliography) selected for “Pillars of Immunology” series by the Journal of Immunology 2007 National Academy of Sciences, elected (to Section 43-Immunology) Fellow, American Academy of Microbiology, elected 2008 Distinguished Alumni Award for Achievement, University of Iowa College of Medicine Class of 2010 Distinguished Service Teaching Award, WUSM 2009 Alpha Omega Alpha (AOA, medical student honor society, elected) American Academy of Arts and Sciences, elected Class of 2011 Distinguished Service Teaching Award, WUSM Fellow, American Association for the Advancement of Science, elected 2009-Date Listed in Best Doctors in America, 2009 (Best Doctors, Inc.) 2010 Lee C. Howley Sr. Prize for Research in Arthritis, National Arthritis Foundation 2011 Carl and Gerty Cori Faculty Achievement Award, Washington University Class of 2013 Distinguished Service Teaching Award, WUSM 2012 Institute of Medicine, elected (to Section 2-Biochemistry, Cellular & Developmental Biology, Medical Microbiology & Immunology, Genetics) Councilor, American Association of Immunologists, elected Class of 2014 Distinguished Service Teaching Award, WUSM 2013 Class of 2015 Distinguished Service Teaching Award, WUSM

Trainee Awards (for Research): 2000 HHMI Medical Student Tuition Program (R. Tomihama, University of Hawaii) (Awarded for exceptional research potential) (declined) 2001 Olin Award for Outstanding Ph.D. Dissertation Research, Division of Biology and Biomedical Sciences, Washington University (L. Wang) 2001 Olin Award for Outstanding Ph.D. Dissertation Research, Division of Biology and Biomedical Sciences, Washington University (H. Smith) 2002 First place, Basic Science Division, First Annual MS2 Research Symposium, University of Hawaii Medical School (C. Hong) 2002 Trainee Best Poster Award, American Society for Clinical Investigation/Association of American Physician Annual Joint Meeting, Chicago, IL (J.W. Heusel) 2002 Best Dissertation Award, Ph.D. Program in Biomedical Sciences, MSSM (A. Dokun) 2004 Olin Award for Outstanding Ph.D. Dissertation Research, Division of Biology and Biomedical Sciences, Washington University (E. Ho) 11. EDITORIAL RESPONSIBILITIES:

Institute (non-government) Reviews: 2001 External reviewer, Istituto Pasteur Fondazione Cenci Bolognetti, Roma, Italy 2004 Faculty Program Reviewer, Pasteur Institute, Paris, France

Grants Review:

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1993 Ad hoc reviewer, Allergy and Immunology Study Section, Division of Research Grants, NIH Ad hoc reviewer, Cellular Immunology Study Section, Arthritis Foundation 1994-1998 Member, Allergy and Immunology (ALY) Study Section, Division of Research Grants, NIH 1995 Reviewer, The Israel Science Foundation, Jerusalem, Israel 1997 Chairman, Special Review Section, Center for Scientific Review, NIH 1998 External reviewer, National Cancer Institute of Canada Reviewer, Department of Veterans Affairs 1999 Chairman, Special Review Section, Center for Scientific Review, NIH Reviewer, Medical Research Council, United Kingdom Reviewer, Science and Technology Center Ukraine Chairman, Special Emphasis Panel, Immunology Program Project, NIAID, NIH 1999-Date Reviewer, Senior Research Fellowships, The Wellcome Trust, London 1999-Date Reviewer, Barnes-Jewish Hospital Research Foundation 2000 Reviewer, (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung (Swiss National Science Foundation) Reviewer, Refurbishment Grants, The Wellcome Trust, London Reviewer, Michigan Biotechnology Grants, The Advisory Group Reviewer, Alberta Heritage Foundation for Medical Research 2001 Chairman, Special Review Section, Center for Scientific Review, NIH Reviewer, Allergy, Immunology, and Transplantation Research Committee, NIAID, NIH Reviewer, Biotechnology and Biological Sciences Research Council, United Kingdom External reviewer, Imperial Cancer Research Fund, London, U.K. Reviewer, Translational Research Grants, NIAMS, NIH 2002 Reviewer, Research Project Grants, Ireland-Northern Ireland Co-operation, Health Research Board, Dublin, Ireland Reviewer, Action Concertee Incitative 2000, Biologie du Developpement et Physiologie Integrative, Ministere de la Recherche, France 2003 Reviewer, The Israel Science Foundation, Jerusalem, Israel Reviewer, Subcommittee C – Basic and Preclinical, National Cancer Institute Initial Review Group (Program Project Grant) Reviewer, The Wellcome Trust, London, U.K. Priority Program “Innate Immunity” Review Panel, DeutscheForschungsgemeinschaft, Berlin, Germany 2004 HHMI External Review Panel for Infectious Diseases and Parasitology Competition Reviewer, Alberta Heritage Foundation for Medical Research 2005 Chairman, Special Emphasis Panel, Center for Scientific Review, NIH Priority Program “Innate Immunity” Review Panel, Deutsche Forschungsgemeinschaft, Bonn, Germany 2006 Reviewer, National Science Foundation 2007-Date Reviewer, Alberta Heritage Foundation for Medical Research Reviewer, HHMI Investigator Competition in Patient Oriented Research Reviewer, HHMI Investigator Competition 2008 Reviewer, Croatia-Israel Joint Research Program Reviewer, Extramural Programme, Agency for Science, Technology, and Research’s (A*STAR) Biomedical Research Council, Singapore 2009 Ad hoc reviewer, Microbiology and Infectious Diseases B Subcommittee, Scientific Review Committee, NIAID, NIH 2011 Reviewer, NIH Director’s Pioneer Awards, NIH Reviewer, Grantová agentura České republiky (Czech Science Foundation) 2012 Study Section, Rheumatic Diseases Core Center P30 grants, NIAMS

Journal Editor 2007 Guest editor, Innate Immunity issue, Current Opinion in Immunology 2009-2011 Associate Editor, Annual Review of Immunology 2011 Guest editor, PLoS Pathogens 2012-2016 Co-Editor, Annual Review of Immunology

Editorial Boards 1995-2006 Editorial Board (Advisory Editor), Journal of Experimental Medicine 1997-2002 Editorial Board, Journal of Clinical Immunology 1999-2004 Editorial Board (Associate Editor), Journal of Immunology

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2001-Date Transmitting Editor, International Immunology 2001-2003 Faculty of 1000, Biology Reports 2002-Date Editorial Board, Immunogenetics 2002-Date Editorial Board, Immunity 2006-Date Section Editor, Medical Immunology Section, Immunology Collection, Biology Image Library, BioMed Central 2006-Date Editorial Board, Immunology and Cell Biology 2007-2008 Editorial Committee, Annual Review of Immunology

Other Editorial Service: 1999-2012 Chair, Editorial Review Group in Rheumatology, Doody Publishing (Rheumatology book reviews)

Journal and Book Reviewer: 1988-Date Journal of Immunology 1989 Fundamental Immunology, Second Edition, W.E. Paul (Ed.), Raven Press 1989-Date Journal of Clinical Investigation 1989-Date Cellular Immunology 1991-Date Regional Immunology 1992-Date European Journal of Immunogenetics 1993-Date Autoimmunity 1994-Date Proceedings of the National Academy of Sciences (USA) 1994-Date Journal of Experimental Medicine 1994-Date Immunity 1994-Date Viral Immunology 1995-Date Nature 1995-Date Science 1996-Date BioTechniques 1996-Date European Journal of Immunology 1997-Date Journal of Clinical Immunology 1997-Date Biochimica et Biophysica Acta 1998-Date Immunology Today 1998-Date Blood 1998-Date Genomics 1998-Date The Journal of Biological Chemistry 1998-Date Arthritis and Rheumatism 1999-Date Journal of Leukocyte Biology 1999-Date Journal of Cell Biology 1999-Date Journal of Investigative Dermatology 2000-Date Kidney International 2000-Date Nature Immunology 2000-Date Gene 2002 Immunobiology, The Immune System in Health and Disease, Fifth Ed., C.A. Janeway, P. Travers, M. Walport, and M. Shlomchik, Garland Publishing, 2001. 2004-Date Journal of Virology New England Journal of Medicine Gene Therapy Genes and Immunity 2004 Immunobiology, The Immune System in Health and Disease, Sixth Ed., C.A. Janeway, P. Travers, M. Walport, and M. Shlomchik, Garland Publishing, 2005. 2005-Date Nature Reviews Immunology 2005-Date AfCS-Nature Signaling Gateway 2006-Date PLoS Pathogens 2007-Date Journal of Molecular Medicine 2008-Date BMC Immunology PLoS Genetics 12. PROFESSIONAL SOCIETIES, FOUNDATION, AND GOVERNMENT SERVICE: 1986-Date American Association of Immunologists (AAI)

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1990-Date Fellow, American College of Rheumatology (ACR) 1991-Date American Federation for Clinical Research (AFCR) 2002-Date American Society for Microbiology 2004-Date Society for Natural Immunity 2012-Date Society for Leukocyte Biology

Professional Society Service: 1991 Abstract Selection Committee, ACR Annual Meeting 1996 Chairman, Immunology Abstract Selection Committee, ACR Annual Meeting 1996-1999 Committee on Clinical Immunology and Immunopathology, AAI 2000-2003 Program Committee, AAI 2003 Nominating Committee, AAI (Elected) 2005-2007 Vice President, Society for Natural Immunity 2008-2012 President, Society for Natural Immunity 2011-2012 Member, Awards Committee, AAI (Elected) 2011-2012 Chair, Awards Committee, AAI 2011 Abstract Selection Committee for Innate Immunity and Rheumatic Diseases, ACR Annual Meeting 2011-Date Temporary Nominating Group (TNG), Class IV, National Academy of Sciences

2012-Date Class IV TNG Representative to Class IV Membership Committee, National Academy of Sciences

2012-2016 Councilor, AAI (Elected) 2013-Date Chair, TNG, Class IV, National Academy of Sciences 2014 At Large Member, Class IV Membership Committee, National Academy of Sciences

Foundation and Other Institutional Service: 1996-2007 Board of Directors, Eastern Missouri Chapter of Arthritis Foundation, St. Louis, MO 1997-1999 Scientific Advisory Board, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 1999-2004 Scientific Advisory Committee, University of Illinois at Chicago School of Medicine, Chicago, IL 2000-2007 Translational Research Advisory Committee, Burroughs Wellcome Fund, Research Triangle Park, NC 2001-2007 Chairman, Medical and Scientific Committee, Eastern Missouri Chapter of Arthritis Foundation, St. Louis, MO 2002-2004 Scientific Advisory Board, Johns Hopkins Singapore Biomedical Center, Singapore 2002-2004 Medical Advisory Council, Missouri Chapter, Lupus Foundation of America, Inc. 2002-2004 Scientific Advisory Board, Research Division, Hospital for Special Surgery, New York, NY 2002-2005 Academic Advisory Board, Pfizer Postdoctoral Fellowship Program in Rheumatology/Immunology 2002-2006 Immunology Study Group, Keystone Symposia on Molecular and Cellular Biology

Government Service: 1998 Director’s Focus Group on Translational Research, Division of Allergy, Immunology, and Transplantation, NIAID 2002 Study Section Boundaries Team, Immunology Integrated Review Group, Center for Scientific Review, NIH 2002 Ad hoc member, National Advisory Allergy and Infectious Diseases Council, NIAID, NIH 2007 Ad hoc member, Board of Scientific Counselors (intramural research review), National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 2012-2016 Board of Scientific Counselors-Basic Sciences (intramural research review), National Cancer Institute, Bethesda, MD 13. MAJOR INVITED PROFESSORSHIPS AND LECTURES:

Visiting Professorships: 1987 Department of Dermatology I, University of Vienna, Vienna, Austria 1993 Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 1997 Australasian Society for Immunology Postgraduate Course, Mundaring Wier, Western Australia

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2000 Immunology Group, Medical College of Virginia, Richmond, VA Division of Orthopaedic Surgery, Department of Surgery, University of Hawaii School of Medicine, Honolulu, HI 2002 Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 2004 Foreign Scientist Visiting Fellowship, Japanese Foundation for AIDS Prevention, Tokyo, Japan 2007 Immunology Program, Harvard Medical School, Boston, MA 2007-09 American Association of Immunologists, Advanced Course in Immunology, Minneapolis, MN 2008 Federation of Clinical Immunology Societies, Advanced Course in Basic and Clinical Immunology, Scottsdale, AZ 2009 Advanced Laboratory Training Course: Viral Subversion of Immune Response. HHMI and Faculty of Medicine, University of Rijeka, Rijeka, Croatia 2010 Visiting Professor, Department of Histology and Embryology, University of Rijeka, Rijeka, Croatia Visiting Professor, Institute for Immunology and National Key Laboratory of Medical Immunology, 2nd Military Medical University, Shanghai, China 2011 Visiting Professor, Institute for Immunology, School for Life Sciences, University of Science and Technology in China, Hefei, China 2012 Lecturer, Immunology Frontier Research Center (iFReC, Osaka University)-Singapore Immunology Network (SIgN) Winter School 2012 on Advanced Immunology, Awaji Island, Japan 2012-13 American Association of Immunologists, Advanced Course in Immunology, Boston, MA 2013 Lecturer, The 2nd Network of Immunology Frontier Winter School on Advanced Immunology, Singapore

Named Lectures: 2000 Eugene M. Lance Memorial Lecture, Hawaii Orthopaedic Association, Honolulu, HI 2003 Distinguished Immunologist Seminar Series, Ohio State University Medical Center, Columbus, OH 2005 Distinguished Immunologist Seminar Series, Childrens’ Hospital Research Foundation, Cincinnati, OH 2008 Australasian Society for Immunology Sponsored Speaker 2012 Dr. Michael Bennett Lecture in Immunopathology, University Lecture Series, University of Texas Southwestern Medical Center, Dallas, TX

Meeting and Symposium Organization: 2001 Keystone Symposium 2001: Interfaces Between Innate and Adaptive Immunity, Keystone, CO (with A. Bendelac, S.N. Vogel) 2003 Keystone Symposium 2003: Linking Innate with Adaptive Immune Responses, Keystone CO (with A. Bendelac) 2003 Antiviral Innate Immunity: Recognition, Defenses, Evasion, and Biodefense Strategies, National Institute of Allergy and Infectious Disease Symposium, Bethesda, MD 2005 Keystone Symposium 2005: Innate Immune Responses to Pathogens (primary organizer with C. Biron, S. Kaufmann) 2005 NK Hawaii 2005: The Society for Natural Immunity Meeting, Sheraton Kauai, Poipu Beach, Hawaii (sole meeting organizer responsible for all aspects of meeting: Locating venue, negotiating hotel contract, budget, scientific program, abstracts, etc.) 2006 American College of Rheumatology, Basic Research Conference: Innate Immunity in the Rheumatic Diseases, Washington, DC (with J.P. Atkinson) 2007 Society for Natural Immunity Symposium at American Association of Immunologists Annual Meeting 2009-10 International Program Committee, 14th International Congress of Immunology, Kobe, Japan 2009-13 Advisory Scientific Committee, 15th International Congress of Immunology, Rome, Italy 2013 The 4th Cellular and Molecular Immunology Symposium on Immunology, Hefei, China

Plenary and Symposium Lectures at International and National Meetings: 1993 Mid-Winter Conference of Immunologists (Asilomar Conference), Pacific Grove, CA Gordon Research Conference (Immunology and Immunochemistry), Oxnard, CA 1994 Keystone Symposium on Stem Cells, Taos, NM Second Meeting of the Society for Natural Immunity, Taormina, Italy Japanese Society for Clinical Immunology, Tokyo, Japan 1995 The 9th International Congress of Immunology, San Francisco, CA

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NK Cell Receptors and Recognition of the Major Histocompatibility Complex Antigens, Insituto Juan March de Estudios e Investigaciones, Madrid, Spain 1996 Mid-Winter Conference for Immunologists (Asilomar conference), Pacific Grove, CA Contemporary Topics in Immunology, American Association of Immunologists annual meeting, New Orleans, LA INSERM Conference on NK Cells and Pregnancy, Clamart, France ACR Frontiers in Basic Research Course, American College of Rheumatology annual meeting, Orlando, FL NK Cells and NK1+ T Cells Symposium, British Society for Immunology annual meeting, Harrogate, United Kingdom 1997 Keystone Symposium on Innate Immunity, Park City, UT 21th Annual UNC Linneberger Comprehensive Cancer Center Annual Symposium, Chapel Hill, NC IV Meeting of the Society for Natural Immunity, Helsinki, Finland Immunology Interest Group Retreat, National Institutes of Health, Airlie House, Airlie, VA Australasian Society for Immunology 27th Annual Scientific Meeting, Perth, Western Australia 1998 Influence of Innate Immunity on Adaptive Immunity, American Association of Immunologists Annual Meeting, San Francisco, CA Conférence Philippe Laudat: Cellules et molecules dans l’implantation (INSERM meeting), Aix-les- bains, France Cancer Vaccine Week 1998, New York, NY Robert Steel Foundation International Symposium, New York, NY Glycobiology ’98, Baltimore, MD Autumn Immunology Conference, Chicago, IL 1999 AAI Annual Meeting, Washington DC 1999 Arthritis Research Conference, Alexandria, VA XVth International Symposium on Glycoconjugates, Tokyo, Japan Annual Meeting of the American Society of Nephrology, Miami, FL 2000 Keystone Symposium on Cellular Immunology and Immunotherapy of Cancer, Santa Fe, NM 10th Anniversary Symposium, The Asan Institute for Life Sciences, Seoul, Republic of Korea CREST International Symposium on Immunoglobulin-Like Receptors, Sendai, Japan Interactions of Innate and Acquired Immunity, Society for Leukocyte Biology, 34th Annual Meeting, Cambridge, MA 2001 Keystone Symposia 2001: Interfaces Between Innate and Adaptive Immunity, Keystone, CO Keystone Symposia 2001: Molecular Aspects of Viral Immunity, Keystone, CO 11th International Congress of Immunology, Stockholm, Sweden 2002 Keystone Symposia 2002: Innate Immunity: Evolution and Link to Adaptive Immunity, Taos, NM Keystone Symposia 2002: Molecular and Cellular Biology of Leukocyte Regulatory Receptors, Tahoe City, CA Pediatric Academic Societies’ Annual Meeting, Baltimore, MD Immunity and Biodefense Workshop, Division of Allergy, Immunology and Transplantation, National Advisory Council, NIAID 13th International Congress of Histocompatibility and Immunogenetics, Seattle, WA Mendelian Resistance to Infectious Diseases: Immunological Implications, Fondation des Treilles, Toutours, Provence, France Innate Immunity Symposium, Infectious Diseases Society of America, Annual Meeting, Chicago, IL 2003 Keystone Symposia 2003: Linking Innate with Adaptive Immunity, Taos, NM International Hannover Workshop on Cytokine Receptors and Cytokine Signaling, Hannover, Germany Fundamental Issues in Vaccine Immunology, The 3rd International Meeting of the Edward Jenner Institute for Vaccine Research, Keble College, Oxford University, Oxford, UK National Institute of Allergy and Infectious Disease Symposium, Innate Immunity to Viral Infections, Bethesda, MD Innate Immunity Symposium, German Society of Immunology 34th Annual Meeting, Berlin, Germany 33rd Annual Scientific Meeting of the Australasian Society for Immunology, Perth, Western Australia 2004 Stimulatory and Inhibitory receptors of the Innate Immune System, Insituto Juan March de Estudios e Investigaciones, Madrid, Spain Immune System Development and Function, 43rd Mid-Winter Conference of Immunologists (Asilomar Meeting), Pacific Grove, CA Innate Immunity, Gordon Research Conference on Immunochemistry and Immunobiology, Buellton, CA Innate Immunity, 10th International Conference on Lymphocyte Activation and Immune Regulation, Newport Beach, CA

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Society for Natural Immunity Symposium at Annual Meeting of American Association of Immunologists: Innate Immunobiology and Host Defense, Washington, DC 8th Meeting of the Society for Natural Immunity and 20th International Natural Killer Cell Workshop, Noordwijkerhout, The Netherlands Meeting on Innate Immunity, Fondation des Treilles, Toutours, Provence, France International Symposium on Innate and Adaptive Immunity after Transcutaneous or Mucosal Vaccination, Fondation Mérieux, Veyrier-du-Lac, France FASEB Summer Research Conference on Lymphocytes and Antibodies, Saxtons River, Vermont 12th International Congress of Immunology, Montreal, Canada Symposium d’Immunologie Bernard Halpern, College de France, Paris, France Annual Meeting of the British Society for Immunology, Harrogate, U.K. 2005 Keystone Symposia 2005: Innate Immunity to Pathogens, Steamboat Springs, CO Viral Immune Evasion, American Society for Microbiology Meeting, Acapulco, Mexico The Emerging Roles of NK and NKT Cells, American Academy of Allergy, Asthma, and Immunology, Annual Meeting, San Antonio, TX Society for Natural Immunity Symposium at Annual Meeting of American Association of Immunologists: NK Cells, San Diego, CA European Network of Immunology Institutes, Annual Meeting, Ile des Embiez, France The 5th Awaji International Forum on Infection and Immunity, Awaji Yumebutai International Conference Center, Hyogo, Japan 9th Society for Natural Immunity Meeting, Poipu Beach, Kauai, HI NK cells and Cytokines: A Symposium in honor of the retirement of Dr. John Ortaldo, Chief, Laboratory of Experimental Immunology, NCI-Frederick, Frederick, MD 2006 Keystone Symposia 2006: Innate Immunity, Banff, Alberta, Canada 2006 National Institute of Allergy and Infectious Diseases Research Conference, Opatija, Croatia American Society for Microbiology Annual Meeting, Orlando, FL 1st Joint Meeting of European National Societies of Immunology, Palais des Congrès, Paris, France Distinguished Review Talk, 8th International Congress of Neuroimmunology, Nagoya, Japan American College of Rheumatology, Basic Research Conference: Innate Immunity in the Rheumatic Diseases, Washington, DC 2007 10th Meeting of the Society for Natural Immunity, NK Cambridge, Cambridge, U.K. X International Congress of Reproductive Immunology, Opatija, Croatia FASEB Summer Conference on Signal Transduction in the Immune System, Snowmass, CO FASEB Summer Conference on Lymphocytes and the Immune System, Tucson, AZ ImmunoRio2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil 37th Annual Meeting, Japanese Society for Immunology, Tokyo, Japan 49th Annual Meeting, American Society of Hematology, Atlanta, GA 2008 Keystone Symposia 2008: NK and NKT Biology, Keystone, CO 2009 British Society for Immunology and American Association of Immunologists Joint Symposium, AAI Annual Meeting, Seattle, WA American Transplant Congress, Annual Meeting, Boston, MA Federation of Clinical Immunology Societies, Annual Meeting, San Francisco, CA 2010 BMT Tandem Meetings, Annual Meeting, Orlando, FL Keystone Symposia 2010: Viral Immunity, Banff, Alberta, Canada American Society for Microbiology, Annual Meeting, San Diego, CA 14th International Congress of Immunology, Kansai, Japan 7th Chinese Society for Immunology Congress of Immunology, Beijing, China 2011 Keystone Symposia 2011: Immunologic Memory. Persisting Microbes and Chronic Disease, Banff, Alberta, Canada Seventh National Meeting, Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases, Denver, CO NK2011, Mainz, Germany 60th Anniversary, Tianjin Medical University, Tianjin, China 2011 Annual Scientific Meeting of American College of Rheumatology, Chicago, IL 2012 2012 National Regional Centers of Excellence in Biodefense Meeting, Amelia Island, FL 13th Meeting of Society for Natural Immunity, Asilomar, Pacific Grove, CA FoCIS 2012, Vancouver, B.C., Canada Frontiers in Immunology in Health and Disease, Cold Spring Harbor Asia Conferences, Suzhou, China Foundations in Basic Immunology, National Cancer Institute, Bethesda, MD 2013 Role of NK Cells in Adaptive Immune Response to HIV-1: Implication for Vaccine Design, Ragon Institute of MGH, MIT, and Harvard, Boston, MA (NIAD sponsored workshop)

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Annual Meeting of American Transplant Congress, Seattle, WA Immunity and Tolerance, LXXVII Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor, NY The 4th Cellular and Molecular Immunology Symposium on Immunology, Hefei, China Association of American Medical Immunologists Annual Meeting, Savannah, GA 15th International Congress of Immunology, Milan, Italy NK2013, 14th Meeting of Society for Natural Immunity, Heidelberg, Germany

Symposium and Workshop Chairmanships: 1993 NK Cell Recognition and MHC Interactions, AAI Annual Meeting, Denver, CO 1994 Recognition by Natural Killer Cells, Keystone Symposium on Lymphocyte Activation, Keystone, CO 1995 Biochemistry of Cellular Activation, ACR Annual Meeting, San Francisco, CA 1996 Symposium, Immunology Group Retreat, WUSM Arthritis and Inflammation, Monsanto/Searle/Washington University Spring Symposium 1997 Natural Killer Cell Receptors, Keystone Symposium on Innate Immunity, Park City, UT Symposium, Immunology Group Retreat, WUSM NK Cell Workshop, Keystone Symposium on Tolerance and Autoimmunity, Keystone, CO Biology of NK Cells, Australasian Society for Immunology 27th Annual Scientific Meeting, Perth, Western Australia 1998 NK Cells: MHC-Recognizing Receptors, American Association of Immunologists Annual Meeting, San Francisco, CA Classical and Non-Classical MHC Class I at the Materno Foetal Interface, Conférence Philippe Laudat: Cellules et Molecules dans L’implantation (INSERM meeting), Aix-les-bains, France Natural Killer Cells: Recognition & Biology, Autumn Immunology Conference, Chicago, IL 1999 NK cells: Ontogeny, Signaling, and Effector Functions, American Association of Immunologists Annual Meeting, Washington, DC Glycoconjugates in Immunology, XVth International Symposium on Glycoconjugates, Tokyo, Japan 2000 MHC Class I NK Cell Receptors, American Association of Immunologists Annual Meeting, Seattle, WA CREST International Symposium on Immunoglobulin-Like Receptors, Sendai, Japan Infection and Immunity Meeting, HHMI, Chevy Chase, MD NK Cells, Interactions of Innate and Acquired Immunity, Society for Leukocyte Biology, 34th Annual Meeting, Cambridge, MA 2001 Keystone Symposia 2001: Interfaces Between Innate and Adaptive Immunity, Keystone, CO Immune system regulation: Basic mechanisms, American Association of Immunologists Annual Meeting, Orlando, FL 2002 Keystone Symposia 2002: Molecular and Cellular Biology of Leukocyte Regulatory Receptors, Tahoe City, CA Mendelian resistance to virus infections, Mendelian Resistance to Infectious Diseases: Immunological Implications, Fondation des Treilles, Toutours, Provence, France 2003 Keystone Symposia 2003: Linking Innate with Adaptive Immunity, Taos, NM Effector Mechanisms and Regulation of Effector Cells, American Association of Immunologists Annual Meeting, Denver, CO National Institute of Allergy and Infectious Disease Symposium, Innate Immunity to Viral Infections, Bethesda, MD 33rd Annual Scientific Meeting of the Australasian Society for Immunology, Perth, Western Australia 2004 Stimulatory and Inhibitory receptors of the Innate Immune System, Insituto Juan March de Estudios e Investigaciones, Madrid, Spain Society for Natural Immunity Symposium at Annual Meeting of American Association of Immunologists: Innate Immunobiology and Host Defense, Washington, DC 8th Meeting of the Society for Natural Immunity and 20th International Natural Killer Cell Workshop, Noordwijkerhout, The Netherlands 2005 Keystone Symposia 2005: Innate Immunity to Pathogens, Steamboat Springs, CO 2006 American College of Rheumatology, Basic Research Conference: Innate Immunity in the Rheumatic Diseases, Washington, DC 2007 NK cells and implantation, X International Congress of Reproductive Immunology, Opatija, Croatia Collaboration between Innate and Adaptive Immunity, FASEB Summer Conference on Lymphocytes and the Immune System, Tucson, AZ 2011 60th Anniversary, Tianjin Medical University, Tianjin, China 2012 Frontiers in Immunology in Health and Disease, Cold Spring Harbor Asia Conferences, Suzhou, China

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Oral Abstract Presentations at International and National Meetings:

1985 American Rheumatism Association, New Orleans, LA 1988 American Association of Immunologists, Las Vegas, NV 1989 7th International Congress of Immunology, Berlin, W. Germany 1990 American Association of Immunologists, New Orleans, LA 1992 Association of American Physicians, Baltimore, MD

1993 American Federation for Clinical Research, Washington, DC

Other Invited Lectures (since 1993): 1993 Immunology Seminar Series, Massachusetts General Hospital, Boston, MA Immunology Lecture Series, Medical College of Virginia, Richmond, VA Rheumatology Grand Rounds, New York University Medical Center, New York, NY Immunology Seminar Series, Committee on Immunology, Harvard Medical School, Boston, MA Immunology Group Seminar, University of Iowa, Iowa City, IA Immunology Group Seminar, University of Toronto, Ontario 1994 Seminar Series, Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA Department of Dermatology, University of Vienna, Vienna, Austria Department of Immunology, Juntendo University, Tokyo, Japan Department of Immunology, Tokyo Medical College, Tokyo, Japan Seminar Series, Committee on Immunology, University of Chicago 1995 Immunology Seminar Series, Department of Pathology, New York University School of Medicine, NY Immunology Seminar Series, Washington University School of Medicine, St. Louis, MO Immunology Lecture, Monsanto Corp., St. Louis, MO Immunology Seminar Series, Sloan-Kettering Institute for Cancer Research, New York, NY Immunology Group Seminar, Merck, Sharpe and Dohme Research Laboratories, Rahway, NJ 1996 Department of Microbiology and Immunology, University of Miami Miami, FL Division of Basic Sciences, NCI-FCRDC, Frederick, MD Immunology Seminar Series, Mt. Sinai Medical Center, NY New York Academy of Sciences, New York, NY Département d’Immunologie, Institut Pasteur, Paris, France The Glycosciences Laboratory, MRC, Northwich Park Hospital, Harrow, Middlesex, United Kingdom 1997 Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX Immunology Program, University of Iowa, Iowa City, IA 8th Annual Rheumatology Symposium, University of Iowa, Iowa City, IA Drug Discovery Group, Genetics Institute, Cambridge, MA Servicio de Inmunología, Hospital de la Princesa, Madrid, Spain Department of Inmunology, Hospital Reina Sofia, and University of Córdoba, Spain National Hospital, University of Oslo, Oslo, Norway John Curtin School of Medical Research, The Australian National University, Canberra, Australia 1998 Department of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico Department of Molecular Biology, Princeton University, NJ Immunology Graduate Program, University of California, San Francisco School of Medicine Department of Molecular and Cell Biology, University of California, Berkeley, CA Cells of the Immune System Symposium, Howard Hughes Medical Institute, Chevy Chase, MD Basel Institute for Immunology, Basel, Switzerland 1999 Immunology Program, Department of Pathology, University of Pennsylvania, Philadelphia, PA Department of Pathology, University of Connecticut, Farmington, CT Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX Immunology Seminar Series, Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA The Burnham Institute (formerly La Jolla Cancer Research Foundation), La Jolla, CA Immunology Seminar Series, WUSM Laboratory of Cancer Biology and Molecular Immunology, University of Tokyo, Tokyo, Japan Laboratoire d’Immunologie, Hôpital Necker, Paris, France Jean Merieux Laboratory, Fondation Marcel Merieux, Lyon, France Facultie d’Medicine, Universite d’Montpelier, Montpelier, France 2000 Immunology Seminar Series, Stanford University Medical Center, Palo Alto, CA Immunology Seminar Series, Department of Microbiology and Immunology, Medical College of Virginia, Richmond, VA Immunology Seminar Series, Johns Hopkins University, Baltimore, MD

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15th Annual Combined Orthopaedic Spring Symposium, Hawaii Orthopaedic Association, Honolulu, HI Department Seminar Series, Department of Microbiology and Immunology, University of Illinois School of Medicine, Chicago, IL Department of Biochemistry, Molecular Biology, and Medicine, University of Ulsan, Seoul, Republic of Korea Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan Immunology Program Seminar, University of Michigan, Ann Arbor, MI Immunology Seminar Series, WUSM 2001 Immunology and Hemostasis Seminar Series, Genetics Institute, Cambridge, MA President’s Lecture Series, Memorial Sloan-Kettering Hospital, NY Immunology Seminar Series, Harvard Medical School, Boston, MA Transplantation Biology Seminar Series, Massachusetts General Hospital, Boston, MA Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, Sweden MPM Capital Group Scientific Retreat on Immunology and Inflammation, Meadowood Resort, CA Medical Grand Rounds, Department of Medicine, WUSM Department of Microbiology and Immunology, The Chicago Medical School, North Chicago, IL Monthly Seminar Series, Chicago Association of Immunologists, Chicago, IL Infection and Immunity Symposium, Howard Hughes Medical Institute, Chevy Chase, MD 2002 Immunology Seminar Series, University of Toronto, Toronto, Ontario, Canada Division of Allergy, Immunology, and Rheumatology, University of Kansas Medical Center, Kansas City, KS Medical Grand Rounds, Department of Medicine, University of Kansas Medical Center, Kansas City, KS Medical Grand Rounds, St. Luke’s Hospital, Chesterfield, MO Department of Dermatology, Ege Üniversitesi Tıp Fakültesi (Ege University Medical School), Izmir, Turkey Division of Allergy, Immunology, and Rheumatology, Akdeniz Universitesi, Antalya, Turkey Immunology Seminar Series, WUSM 2003 Immunology Seminar Series, NIAID-Twinbrook, Rockville, MD Innate and Adaptive Immunity Seminar Series, Jerome Holland Research Laboratory, American Red Cross, Rockville, MD Joint Immunology Seminar Series, La Jolla Institute for Allergy and Immunology, La Jolla, CA Immunology Affinity Group Seminar Series, The Scripps Research Institute, La Jolla ,CA Program in Immunology Seminar Series, University of Alabama at Birmingham, Birmingham, AL Immunology Colloquium, Moffitt Cancer Center, University of South Florida, Tampa, FL Wilmot Cancer Center Seminar Series, University of Rochester Medical Center, Rochester, NY Research Seminar Series, Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL Continuing Medical Education Symposium, University of Hawaii School of Medicine 25th Reunion, Honolulu, HI Immunology Seminar, Robert Koch-Institut, Berlin, Germany Genetics Departmental Seminar, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX Departmental Seminar, Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, St. Louis, MO 2004 Inaugural MRCE Seminar on Biodefense, WUSM Immunology R & D Group, Lilly Corporate Research Center, Indianapolis, IN Department of Immunology Seminar Series, University of Washington, Seattle, WA Seminar Series, Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA Medical Grand Rounds, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY AIDS Research Center, National Institute of Infectious Diseases, National Institute of Health, Tokyo, Japan Immunology Seminar, National Institute of Infectious Diseases, National Institute of Health, Shinjuku-ku, Tokyo, Japan Immunology Seminar, Research Institute for Biological Science, Tokyo University of Science, Noda- City, Chiba, Japan Department of Immunology, Tokyo Medical University, Tokyo, Japan

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Department of Integrated Biosciences, Graduate School of Frontier Biosciences, University of Tokyo, Kashiwa, Chiba, Japan Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands Tumor Immunology Series, Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY Sir William Dunn School of Pathology, Oxford University, Oxford, U.K. 2005 Immunology Program Student Seminar Series, Stanford University, Palo Alto, CA Integrated Department of Immunology Seminar, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO Immunology Club, New York University School of Medicine, New York, NY Clinical Allergy for the Practicing Physician, CME course, WUSM 2006 Immunology Interest Group, National Institutes of Health, Bethesda, MD Nephrology, Immunology, and Transplantation Seminar Series, University of Cambridge, Cambridge, UK Immunology Group Seminar Series, University of Iowa, Iowa City, IA Medical Grand Rounds, University of Iowa, Iowa City, IA Molecular Microbiology and Microbial Pathogenesis Seminar Series, WUSM Lineberger Comprehensive Cancer Center Seminar Series, University of North Carolina, Chapel Hill, NC Department of Microbiology and Immunology, Penn State Milton S. Hershey Medical Center, Hershey, PA Progress in Internal Medicine, Department of Medicine, University of Iowa Hospitals, Iowa City, IA Visiting Scientist Seminar, Department of Immunology, National Institute of Neuroscience, National Center for Neurology and Psychiatry, Kodaira, Tokyo, Japan 2007 Student’s Choice Speaker, Committee on Immunology, University of Chicago, Chicago, IL Immunology and Molecular Pathogenesis Seminar Series, Emory University, Atlanta, GA HHMI/NIH Research Scholars Program, Bethesda, MD Seminar Series, Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD Immunology Seminar Series, Harvard Medical School, Boston, MA Clinical Allergy for the Practicing Physician, CME course, Washington University, St. Louis, MO Laboratory for Autoimmune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan Department of Immunology, Kyoto University School of Medicine, Kyoto, Japan 2008 Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland, OR Immunology Seminar Series, Washington University, St. Louis, MO Special Seminar, Immunology Group, Blood Research Institute of Blood Center of Wisconsin, Milwaukee, WI Keynote speaker, Markey Program Retreat, Washington University Internal Medicine Grand Rounds, University of Iowa Hospitals Immunology Seminar Speaker, University of Iowa Hospitals, Iowa City, IA Institut für Medizinische Mikrobiologie, Immunologie & Hygiene, Technische Universität München, Munich, Germany Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, South Australia Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Sydney, New South Wales, Australia Grand Rounds, Department of Medicine, Southern Illinois School of Medicine, Springfield, IL 2009 Seminar Series, Immunology and Virology Group, University of Massachusetts Medical School, Worcester, MA Medical Scientist Advisory Group, Vanderbilt University, Nashville, TN Distinguished Lecture Series, Fox Chase Cancer Center, Philadelphia, PA Seminar Series, Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC Allergy Grand Rounds, Washington University School of Medicine 2010 Spring City-wide FOCIS Workshop on NK Cells (Chicago), Children’s Hospital, Chicago, IL Rheumatology Grand Rounds and Clinical Conference, University of Alabama at Birmingham Immunology Seminar Series, UAB 2011 Seminar Series, Department of Immunobiology, University of Arizona, Tucson, AZ Immunology Colloquium, University of Pennsylvania, Philadelphia, PA Special Lecture, Department of Histology and Embryology, University of Rijeka, Rijeka, Croatia

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Immunology and Microbial Pathogenesis Seminar, Memorial Sloan Kettering Cancer Center, New York, NY Immunology and Infectious Diseases Seminar Series, University of Vermont School of Medicine, Burlington, VT 2012 Department of Microbiology and Immunology, Northwestern University School of Medicine, Chicago, IL Microbiology, Immunology, and Cancer Biology Seminar Series, University of Minnesota, Minneapolis, MN Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, Spain Institute for Immunology, School for Life Sciences, University of Science and Technology in China, Hefei, China The MD/PhD-MD/Master’s Program Committee, Queen’s University, Kingston, Ontario, Canada Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada Grand Rounds, Department of Pediatrics, University of Hawaii and Kapi`olani Medical Center for Women and Children, Honolulu, HI 2013 Department of Microbiology and Immunology, Stanford University, Palo Alto, CA Department of Microbiology and Immunology, Michigan State University, East Lansing, MI 14. CONSULTING RELATIONSHIPS AND BOARD MEMBERSHIPS: 2001 Research Advisory Meeting, MPM Capital Group, San Francisco, CA 2002 Plant Biologics Medical Advisory Group, Monsanto Company, St. Louis 15. RESEARCH SUPPORT:

Governmental: 1984 Veterans’ Administration Associate Investigator Award: (declined) 1984-1987 NIH F32-AM07219 (Individual National Research Service Award); “Drug effects on antibody synthesis in vitro”, Total direct costs: $80,000 1989-1992 NIH AR20684 Multipurpose Arthritis Center Grant (I. M. Goldstein, PI) (Development and Feasibility Award); “Molecular cloning of the NK1.1 antigen,” Total direct costs: $150,000 1990-1994 NIH R29-AI29981 (FIRST Award); “Molecular characterization of the A1 multigene family,” Total direct costs: $327,124 (Relinquished after 4 years to accept second RO1). 1992-1995 NIH RO1-AI33903; “Interaction of MHC with Ly-49 on NK cells,” Total direct costs: $450,076 1994-1996 NIH PO1-AI24671, “Cellular and molecular studies of autoimmune diseases” (C. Bona, PI), Project 5: “Natural killer cell function in autoimmunity,” Total direct costs: $165,103 (Relinquished upon relocation to Washington University.) 1994-1999 NIH RO1-AI34385, “Expression, specificity and function of Ly-49 family,” Total direct costs: $720,404 1996-2001 NIH RO1-AI33903, “Interaction of MHC with Ly-49A on NK cells,” Total direct costs: $883,572. 1997-2001 NIH U19-AI34580; “Asthma, Allergic, and Immunologic Diseases Cooperative Research Center” (D. Chaplin, PI), Project 4: “Role of NK cells in innate immunity to pathogens,” Total direct costs: $450,000. 1999-2002 NIH RO1-AI34385, “Expression, specificity and function of Ly-49 family,” Total direct costs: $423,772 2000-2004 NIH PO1-AI47330, “The Syk tyrosine kinase” (A. Chan, PI), Project 4: “Role of Syk in NK cell function,” Total direct costs: $659,101 2002-2007 NIH RO1-AI51345, “Specificity of murine CMV resistance by NK cells,” Total direct costs: $1,000,000. 2002-2007 NIH RO1-AI33903, “In vivo development of NK cells,” Total direct costs: $875,000 2002-2007 NIH R37-AI34385, “Activation receptors on NK cells,” Total direct costs: $875,000 (MERIT Award) 2003-2008 NIH U54-AI57160, “Midwest Center for Regional Excellence in Biodefense and Emerging Infections” (S. Stanley, PI); Section leader on “Innate immunity to viruses” and subproject 1 PI: “Innate natural killer responses to viral infections,” Total direct costs for subproject 1: $1,125,000 Award) 2007-2012 NIH RO1-AI51345, “NK cell response to MCMV infections,” Total direct costs: $1,000,000. 2007-2012 NIH RO1-AI33903, “In vivo development of NK cells,” Total direct costs: $875,000. 2007-2013 NIH R37-AI34385, “Activation receptors on NK cells,” Total direct costs: $875,000 (MERIT Award)

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2009-2014 NIH U54-AI57160, “Midwest Center for Regional Excellence in Biodefense and Emerging Infections” (H.W. Virgin IV, PI); Section leader on “Viral Immune Evasion ” and subproject 1 PI: “Innate NK cell responses to poxvirus infections,” Total direct costs for subproject 1: $1,125,000 2012-2016 NIH RO1-AI33903, “In vivo development of NK cells,” Total direct costs: $800,000. 2012-2017 NIH RO1-AI51345, “NK cell response to MCMV infections,” Total direct costs: $1,000,000. 2013-2016 NIH RO1-AI106561, “Liver-resident natural killer cells, viral infection, hepatitis, and memory,” (U.S.-China Program for Biomedical Collaborative Research) Total direct costs: $387,691.

Center Grant Leadership: 2001-2006 NIH P30-AR48335, “Rheumatic Diseases Core Center,” Total direct costs: $2,000,000. 2006-2011 NIH P30-AR48335, “Rheumatic Diseases Core Center,” Total direct costs: $2,000,000. 2011-2016 NIH P30-AR48335, “Core Center,” Total direct costs: $2,000,000.

Conference Grants: 2003 NIH 1R13-AI053503, “Linking innate with adaptive immune responses,” Total direct costs: $10,000 (Keystone Symposia meeting support) 2005 NIH 1R13 AI068402-01, “Conference of the Society for Natural Immunity,” Total direct costs: $16,800 (Conference support grant for NK meeting in Hawaii) 2010 NIH 1R13-AI089016-01, “Conference of the society for Natural Immunity,” Total direct costs: $7,000 (Conference support grant for NK meeting in Dubrovnik, Croatia)

Institutional Training Grants: 1997-2002 NIH T32-AR07279, “Immunobiology of the rheumatic diseases” (training grant), Total direct costs: $1,046,469. 2003-2008 NIH T32-AR07279, “Immunobiology of the rheumatic diseases” (training grant), Total direct costs: $1,589,652. (Taken over by J.P. Atkinson) 2007-2009 NIH T32-GM007200, “National Research Service Award-Medical Scientist” (MSTP training grant): Total direct costs: $4,678,502 (Taken over from D. Goldberg) 2010-2015 NIH T32-GM007200, “National Research Service Award-Medical Scientist” (MSTP training grant), Total direct costs: $11,696,255

Non-governmental: 1982 Arthritis Foundation (Iowa Chapter) Research Grant; “Immunoregulation in drug induced lupus”, Total direct costs: $5,000 1983 Lupus Foundation Research Grant; “Immunoregulation in drug induced lupus”, Total direct costs: $15,000 1984 Arthritis Foundation Post-doctoral Fellowship (declined) 1990 Arthritis Foundation (Northern Chapter, California) Research Grant; “Genomic organization of the A1 multigene family,” Total direct costs: $15,000 1990 UCSF Academic Senate/Research Evaluation and Allocation Committee Research Award; “Role of Ly-49 in NK cell adhesion,” Total direct costs: $15,000 1991 Arthritis Foundation (Northern Chapter, California) Research Grant; “NK cell specific proliferation,” Total direct costs: $9,000 1991 University of California Cancer Research Coordinating Committee Research Grant; “NK cell specific genetic loci,” Total direct costs: $35,000 1994-1995 Howard Hughes Medical Institute (voluntary resignation to accept position at Washington University) 1996-1997 Monsanto/Searle-Washington University Research Grant; “Transgenic analysis of NK cell function,” Total direct costs: $175,000 (Relinquished in second of three years as condition of HHMI appointment). 1996 Jewish Hospital Research Foundation; “Tissue-specific deletion of functional genes in transgenic mice,” Total direct costs: $67,198. 1997-Date Howard Hughes Medical Institute 2004-Date Federation of Clinical Immunology Societies (FOCIS) Center for Allergic and Autoimmune Diseases (Co-Director) 2005 Washington University-Pfizer Biomedical Research Program (Planning Grant); “Multi- Disciplinary Studies of Inflammatory Arthritis,” Total direct costs: $15,000

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Sponsored Trainee Fellowships and Awards: 1990-1992 Max Kade Foundation Fellowship (Franz Karlhofer, M.D.); “Molecular mechanisms in NK cell recognition of target cells,” Total direct costs: $37,500 1992 Arthritis Foundation Postdoctoral Fellowship (Brian F. Daniels, M.D.); “Direct demonstration of Ly-49 interaction with MHC class I antigen”, Total direct costs: $59,000 1994-1997 Irvington Institute for Medical Research Postdoctoral Fellowship (Michael G. Brown, Ph.D.); “Structure and expression of the Ly-49A gene,” Total direct costs: $81,000 1994-1996 Aaron Diamond Foundation Postdoctoral Fellowship (Michael G. Brown, Ph.D.); “Structure and expression of the Ly-49A gene,” Total direct costs: $75,000 (declined) 1994-1996 NIH F31-CA67716 (Individual NRSA Predoctoral Fellowship) (Azza Idris); “Tumor specific murine natural killer cell clones,” Total direct costs: $27,616 1995-2000 NIH KO8-HD01083 (Clinical Investigator Development Award) (Amy Reichlin, M.D.); “Functional development of natural killer cells,” Total direct costs: $369,373 1997 American College of Rheumatology Summer Student Research Internship (Joel Schilling, MSI); “The role of Cmv1 in NK cell mediated resistance to bacterial infections.” 1997-2000 HHMI Postdoctoral Research Fellowship for Physicians (Jonathan W. Heusel, M.D., Ph.D.); “The role of Ly-49 molecules as ‘missing-self’ receptors on natural killer cells.” (National competition.) 1997-2000 Pfizer Postdoctoral Research Fellowship (Jonathan W. Heusel, M.D., Ph.D.); “The role of Ly-49 molecules as ‘missing-self’ receptors on natural killer cells.” (declined) 1999-2000 HHMI Medical Student Fellowship (Roger Tomihama, MSII at University of Hawaii); “The role of NK cells in tumor surveillance.” 2000 NIH NRSA (Suellen Greco, D.V.M.); “In vivo analysis of NK cell tumor surveillance” (declined) 2000 HHMI-Washington University Internal Clinical Investigator Faculty Development Award (Leonidas Carayannopoulos, M.D., Ph.D.) 2002 HHMI-Washington University Internal Clinical Investigator Faculty Development Award (Anthony R. French, M.D., Ph.D.) 2003 HHMI Pre-doctoral Fellowship (Jane Yen, Ph.D. candidate in Immunology) 2004-2008 NIH KO8-AI059083 (Mentored Clinician Scientist Development Award) (Anthony R. French, M.D., Ph.D.); “Natural killer cell mediated control of vaccinia virus,” Total direct costs: $403,950. 2004-2006 American Gastroenterology Association Foundation for Digestive Disease Health and Nutrition, AstraZenca Fellowship/Faculty Transition Award (Sandeep K. Tripathy, M.D., Ph.D.) “Role of m157, a ligand for Ly49H activation receptor, in activation of hepatic NK cells; Total direct costs: $80,000. 2004-2009 NIH KO8-AI057361 (Mentored Clinician Scientist Development Award)(Leonidas Caryannopoulos, M.D., Ph.D.); “Molecular physiology of NKG2D ligand expression,” Total direct costs: $477,955 2004-2009 NIH KO8-DE016083 (Mentored Clinician Scientist Development Award)(John B. Sunwoo, M.D.); “Mechanisms of immune evasion by head and neck cancer,” Total direct costs: $566,651. 2005 Max Kade Foundation Fellowship (Achim Schneeberger, M.D.); Total direct costs: $56,000 2006-2009 NIH KO8-AI071016 (Mentored Clinician Scientist Development Award) (Sandeep Tripathy, M.D., Ph.D.); “The role of activating receptors in natural killer cell development,” Total direct costs: $332,270. 2007-2010 Abbott Scholar Award in Rheumatology Research (Tammy Cheng, M.D.); “Genomic signatures of immunoevasive murine cytomegalovirus mutants,” Total direct costs: $241,000. 2007-2008 HHMI Medical Student Fellowship (Kimberly Hsu, WUMSII); “Peritoneal sentinel cells.” 2007-2008 Dermatology Foundation Dermatologist Investigator Research Fellowship (Paul Klekotka, M.D., Ph.D.); “The role of natural killer cells in contact hypersensitivity,” Total direct costs: $30,000. 2010-2015 NIH KO8-AI085030 (Mentored Clinician Scientist Development Award) (Megan Cooper, M.D., Ph.D.); “Mechanisms of innate immune memory,” Total direct costs: $392,356 2013 HHMI Medical Student Summer Fellowship (Jenny Yu, WUMSI); “Liver memory NK cells.” 16. CLINICAL TITLE AND RESPONSIBILITIES:

Attending Physician, Rheumatology Division, Department of Medicine, Barnes-Jewish Hospital Consultant, Department of Medicine, John Cochran Veteran’s Administration Medical Center Attending Duties

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1995-Date Firm C Internal Medicine Attending Physician (1 mo/yr) 1995-Date Rheumatology Consultation Services Attending Physician (1 mo/yr) 1996 Rheumatology Clinic Physician, WUSM, St. Louis (weekly clinic) 1996-1997 Rheumatology Clinic Physician, VAMC, St. Louis (weekly clinic) 2000-Date Rheumatology Clinic Physician, WUSM, St. Louis (occasional clinic coverage) 17. TEACHING TITLE AND RESPONSIBILITIES:

Professor of Medicine and of Pathology and Immunology, Washington University School of Medicine Medical School Teaching

1996-Date Pathophysiology of Disease, WUSM (Physical Diagnosis, Rheumatology, Vasculitis, SLE) 1997-Date Medical Immunology, WUSM (discussion section leader on clinical cases) 2000-Date Elective in Medical Immunology, WUSM

Internal Medicine Residency Teaching 2001 Vasculitis Syndromes, Core Curriculum Conference, Department of Medicine, WUSM and Barnes-Jewish Hospital 2001-Date Guest Chief of Service, WUSM 2001-Date Firm Conference Faculty Participant 2004 Approach to Vasculitis, Core Curriculum Conference, Department of Medicine, WUSM and Barnes-Jewish Hospital 2005 Vasculitis, Medical Resident Core Curriculum, Barnes-Jewish Hospital

Continuing Medical Education 1995 7th Biennial Allergy Abroad, Vienna, Austria 1997 8th Biennial Allergy Abroad, Madrid, Seville, Granada, and Barcelona, Spain 1999-2000 American College of Rheumatology CME Course for Primary Care Physicians (4 separate day- long seminars) 1999 9th Biennial Allergy Abroad, Paris, Lyon, and Montpelier, France 2002 10th Biennial Allergy Abroad, Istanbul, Izmir, and Antalya, Turkey 2005 Allergy Update, WUSOM 2007 Allergy Update, WUSOM 2012 Allergy for the Practicing Physician, WUSOM

Graduate Teaching: 1992-1995 Immunology graduate course, MSSM (T cell immunology: T cell receptors, TCR/CD3 complex, T cell activation, T cell co-receptors, T cell development; NK cells) 1993-1995 Biochemistry and Molecular Biology core course, MSSM (Techniques for analysis of proteins) Cell and Molecular Biology core course, MSSM (Immune system: General overview, humoral and cellular immunity, TCR/CD3 complex, MHC and antigen presentation) 1994-1995 Advanced study in immunobiology, MSSM (Natural killer cells) 1994-1995 Coordinator, Immunobiology Journal Club, MSSM 1996-Date Foundations of Immunology, WUSM (Introduction to the immune response, NK cells) 1998 Molecular Mechanisms of Disease, WUSM (Etiology and pathogenesis of systemic vasculitis) 1999 Coursemaster, Lucille B. Markey Special Emphasis in Human Pathobiology: Rheumatoid Arthritis 2000 Molecular Mechanisms of Disease, WUSM (Coursemaster for subsection on Rheumatoid Arthritis) 2001 Lucille B. Markey Special Emphasis in Human Pathobiology: Systemic lupus erythematosus (genetics) 2001-2004 Coursemaster, Molecular Mechanisms of Immunological Diseases, Division of Biology and Biomedical Sciences, Washington University 2002-2011 Coursemaster, Human Immunobiology Pathway, Division of Biology and Biomedical Sciences, Washington University 2007 Faculty, Grant writing workshop, DBBS, WUSM 2007-2011 Coursemaster, Molecular Mechanisms of Immunological Diseases, Division of Biology and Biomedical Sciences, Washington University

Ph.D. Second Level Examinations:

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1994 X. Y. Yio, Department of Microbiology, MSSM 1995 F. Chuang, Department of Physiology and Biophysics, MSSM 1995 A. Fernandez, Department of Microbiology, MSSM 1996 G. Schreiber, Immunology Graduate Program, WUSM D. Peterson, Immunology Graduate Program, WUSM 1997 T. Cireto, Immunology Graduate Program, WUSM S. Martin, Immunology Graduate Program, WUSM A. Delcanto, Immunology Graduate Program, WUSM R. Presti, Immunology Graduate Program, WUSM 1998 E. Clamby, Immunology Graduate Program, WUSM M. Zhou, Immunology Graduate Program, WUSM B. Edelson, Immunology Graduate Program, WUSM 1999 J. Brewer, Immunology Graduate Program, WUSM S. Resnick, Immunology Graduate Program, WUSM 2000 D. Popkin, Immunology Graduate Program, WUSM Z. Kim, Immunology Graduate Program, WUSM P. Velazquez, Immunology Graduate Program, WUSM 2001 S. Kang, Immunology Graduate Program, WUSM S. McClellan, Immunology Graduate Program, WUSM A. Lane, Immunology Graduate Program, WUSM 2002 A. Bredemeyer, Immunology Graduate Program, WUSM A. Miletic, Immunology Graduate Program, WUSM C. Neuman, Immunology Graduate Program, WUSM A. Bhatia, Immunology Graduate Program, WUSM 2004 P. Wilker, Immunology Graduate Program, WUSM 2005 R. Akilesh, Immunology Graduate Program, WUSM S. Cai, Immunology Graduate Program, WUSM 2006 R. Belizaire, Immunology Graduate Program, WUSM B. Miller, Immunology Graduate Program, WUSM 2007 W.J. Chua, Immunology Graduate Program, WUSM J. Lynch, Immunology Graduate Program, WUSM 2008 E. Miller, Immunology Graduate Program, WUSM M. Vogt, Immunology Graduate Program, WUSM S.H. Lee, Immunology Graduate Program, WUSM 2009 J. Lee, Immunology Graduate Program, WUSM G. Sandoval, Immunology Graduate Program, WUSM Y. Wang, Immunology Graduate Program, WUSM E. Gapud, Immunology Graduate Program, WUSM 2010 N. Manieri, Immunology Graduate Program, WUSM P. Ni, Immunology Graduate Program, WUSM C. Decker, Immunology Graduate Program, WUSM

Ph.D. Thesis Committees: 1993 Y. Natkunam (Thesis advisor: S. Chen-Kiang), Brookdale Center for Molecular Biology, MSSM 1997 M. Güler (Thesis advisor: K. Murphy), Imm Grad Prog, WUSM P. Kulesza (Thesis advisor: M. Lieber), Imm Grad Prog, WUSM T. Hornell (Thesis advisor: T. Hansen), Imm Grad Prog, WUSM R. Latek (Thesis advisor: E. Unanue), Imm Grad Prog, WUSM 1998 VJ Shankaran (Thesis advisor: R. Schreiber), Imm Grad Prog, WUSM A. Dal Canto (Thesis advisor: H. Virgin), Imm Grad Prog, WUSM W. Ouyang (Thesis advisor: K. Murphy), Imm Grad Prog, WUSM D. Plas (Thesis advisor: M. Thomas), Imm Grad Prog, WUSM H. Hansen (Thesis advisor: R. Schreiber), Imm Grad Prog, WUSM J.B. Wardenberg (Thesis advisor: A. Chan), Imm Grad Prog, WUSM R. Presti (Thesis advisor: H. Virgin), Imm Grad Prog, WUSM 1999 B. Edelson (Thesis advisor: E. Unanue), Imm Grad Prog, WUSM X.-C. Xu (Thesis advisor: T. Mohanakumar), Imm Grad Prog, WUSM L. I. Yoo (Thesis advisor: S. Speck), Imm Grad Prog, WUSM 2000 R. Pappu (Thesis advisor: A.C. Chan), Imm Grad Prog WUSM D. Thomas (Thesis advisor: T. Ley), Imm Grad Prog, WUSM G. Schreiber (Thesis advisor: R. Schreiber), Imm Grad Prog, WUSM

Page 20 CV: Yokoyama

S. Ranganath (Thesis advisor: K. Murphy), Imm Grad Prog, WUSM A. Suri (Thesis advsior: E. Unanue) Imm Grad Prog, WUSM V. Von Berkel (Thesis advisor: H. Virgin) Imm Grad Prog, WUSM J. Schilling (Thesis advisor: S. Hultgren) Imm Grad Prog, WUSM 2001 H. Johnson (Thesis advisor: T. Ley) Imm Grad Prog, WUSM C. Zindel (Thesis advisor: D. Chaplin) Imm Grad Prog, WUSM M. Miley (Thesis advisor: D. Fremont) Bio-organic Grad Prog, WUSM J. Ondr (Thesis advisor: C. Pham) Imm Grad Prog, WUSM 2002 A. Lane (Thesis advisor: T. Ley) Imm Grad Prog, WUSM S. McClellan (Thesis advisor: H. Virgin) Imm Grad Prog, WUSM S. Kang (Thesis advisor: P. Allen) Imm Grad Prog, WUSM 2003 P. Arnold (Thesis advisor: D. Fremont) Biochem Grad Prog, WUSM S. Truscott (Thesis advisor: T. Hansen) Imm Grad Prog, WUSM 2004 T. Wilson (Thesis advisor: M. Colonna) Imm Grad Prog, WUSM A. Steed (Thesis advisor: H. Virgin) Imm Grad Prog, WUSM A. Blasius (Thesis advisor: M. Colonna) Imm Grad Prog, WUSM P. Wilker (Thesis advisor: K. Murphy) Imm Grad Prog, WUSM G. Nybaacken (Thesis advisor: D. Fremont) Imm Grad Progm WUSM 2005 K. Chachu (Thesis advisor: H. Virgin) Imm Grad Prog, WUSM M. Diamond (Thesis advisor: R. Schreiber) Imm Grad Prog, WUSM E. Moulton (Thesis advisor: J. Atkinson) Imm Grad Prog, WUSM 2006 S. Kim (Thesis advisor: T. Hansen) Imm Grad Prog, WUSM 2007 J. Ireland (Thesis advisor: E. Unanue) Imm Grad Prog, WUSM J. Campbell (Thesis advisor: L. Carayannopoulos) Immunology, WUSM R. Belizaire (Thesis advisor: E. Unanue) Imm Grad Prog, WUSM 2008 C.-W. Lio (Thesis advisor: C. Hseih) Imm Grad Prog, WUSM S. McCartney (Thesis advisor: M. Colonna) Imm Grad Prog, WUSM B. Strong (Thesis advisor: E. Unanue) Imm Grad Prog, WUSM W.-J. Chua (Thesis advisor: T. Hansen) Imm Grad Prog, WUSM M. Veseley (Thesis advisor: R. Schreiber) Imm Grad Prog, WUSM 2009 S. Austin (Thesis advisor: M. Diamond) Imm Grad Prog, WUSM M. Mashayekhi (Thesis advisor: K. Murphy) Imm Grad Prog, WUSM C.-W. Yang (Thesis advisor: K. Murphy) Imm Grad Prog, WUSM Y.-S. Chen (Thesis advisor: R. Schreiber) Mol Genetics and Genomics Prog, WUSM W. McCoy IV (Thesis advisor: D. Fremont) Imm Grad Prog, WUSM

Visiting Member of Ph.D. Thesis Committees: 1997 E. Dissen (First opponent) (Thesis advisor: S. Fossum), Department of Immunology, University of Oslo, Oslo, Norway 2001 M. Eriksson (First opponent) (Thesis advisor: C. Sentman), Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, Sweden 2004 A. Marshall (Thesis advisor: Siamon Gordon), Sir William Dunn School of Pathology, Oxford University, Oxford, England 2005 A. Parker (Thesis advisor: R. Mark Buller), St. Louis University School of Medicine, St. Louis, MO

Ph.D. Rotation Students (non-thesis) 1996 Megan Jacoby (MSTP) 1997 Ben Palanca (MSTP)

1999 Andrew Lane (MSTP) 2000 Alessandra Colic (Immunology Ph.D.) Claire Perchonock (Immunology Ph.D.) 2001 Catherine Koebel (Immunology Ph.D.) Timothy Wilson (Immunology Ph.D.) 2002 Jane Yen (Immunology Ph.D.) 2004 Erin McCandless (Immunology Ph.D.) Margaret Snow (Immunology Ph.D.) Grace Kao (MSTP) 2005 Kerri Burson (Molecular Microbiology Ph.D.) Erin Filbert (Immunology Ph.D.) 2006 Elizabeth Miller (Immunology Ph.D.)

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2008 Clara Moon (Immunology Ph.D.) Lulu Sun (MSTP) 2009 Lauren Shea (MSTP) Hyelim Cho (Molecular Microbiology Ph.D.) 2013 Nicholas Jarjour (Immunology Ph.D.)

Ph.D. Thesis Advisor (with last known position): (n=16) 1993-1999 Sungjin Kim, Brookdale Center for Molecular Biology, MSSM (Asst Prof, Dept Micro Immunol, Michigan State U, East Lansing, MI) 1993-1999 Azza Idris (MSTP), Immunology Program, MSSM (Pediatrics private practice, Pace, FL) 1994-2001 Ayotunde Dokun (MSTP), Immunology Program, MSSM (Assistant Professor, Division of Endocrinology, University of Virginia) 1994-2001 Hamish Smith, Immunology Graduate Program, WUSM (Post-doctoral fellow, Genentech) 1994-2001 Indira Mehta, Immunology Graduate Program, WUSM (Post-doctoral fellow in Human Genetics, University of California, San Francisco) 1995-2000 Lawrence Wang (MSTP), Immunology Graduate Program, WUSM (Private practice, St. Louis) 1995-2000 Dortha T. Chu (MSTP), Immunology Graduate Program, WUSM (Pediatric surgery fellowship, Oregon Health & Sciences University, Portland, OR) 1997-2001 Hubert H. Chuang (MSTP, 2002), Immunology Graduate Program, WUSM (Assistant Professor, Department of Nuclear Medicine, M.D. Anderson Cancer Center, Houston) 1998-2002 Emily L. Ho (MSTP, 2004), Immunology Graduate Program, WUSM (Post-doctoral research fellow, Dept Neurology, University of Washington, Seattle) 2003-2006 Randall Rodrigues (MSTP), Immunology Graduate Program, WUSM (Computer consultant, Guam)(Left MSTP voluntarily due to wife’s deployment in US Navy) 2004-2009 Minji Byun, Immunology Graduate Program, WUSM (Post-doc fellow, Rockefeller U, NYC) 2005-2011 Claudia Vargas, Immunology Graduate Program, WUSM (PharmD program, UCSF) 2006-2010 A. Helena Jonsson (MSTP), Immunology Graduate Program, WUSM (Internal Medicine Resident, Brigham and Women’s Hospital, Boston, MA) 2007-2011 Julie Elliott, Immunology Graduate Program, WUSM (Medical student, U. Missouri, Columbia, MO) 2007-2012 Melissa Pak, Immunology Graduate Program, WUSM 2008-2012 Chris Affolter, Molecular Microbiology Graduate Program, WUSM (resigned for personal reasons) 2013-present Eugene Park (MSTP), Immunology Graduate Program, WUSM 2013-present Swapneel Patel (MSTP), Immunology Graduate Program, WUSM

M.D. Research Mentor 1986-1987 Steven Maxfield, Duke University; HHMI Cloisters Program at NIH (Radiology Practice, Arizona) 1997 Joel Schilling, WUSM (Cardiology fellow, Barnes-Jewish Hosp, St. Louis) 1999-2000 Roger T. Tomihama, University of Hawaii; HHMI Research Fellowship (Radiology resident, Yale University) 2000 Laura Belorgey, Medical Student, University of Hawaii (Private practice in Neurology, Conroe, TX, now known as Laura B. Bonds, MD) 2001 Caron M. Hong, University of Hawaii (Instructor of Anesthesiology, University of Maryland Medical Center, Baltimore, MD) 2004 Kenneth R. Ziegler, WUSM 2004 John Huetsch, WUSM 2006 Kimberly Hsu, WUSM 2013 Jenny Yu, WUSM

M.D.-M.A. Thesis Advisor: 1997-1998 Emily L. Ho (Neurology Research Fellow, University of Washington, Seattle) 2007-2008 Kimberly Hsu, WUSM (Ophthalmology Resident, Barnes-Jewish Hospital)

M.D. Independent Study: 2007 Jennifer Alexander Brett, WUSMIV (Evolution of drug therapy for rheumatoid arthritis)

Basic Research Post-doctoral Training (with last known position): (n=41)

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1990-1993 Franz Karlhofer, M.D. [Dozent (tenured Professor), Dept Dermatology, U Vienna, Austria] 1991-1992 Brian F. Daniels, M.D. (Senior Vice-President, Global Development & Medical Affairs, Bristol- Myers Squibb, Princeton, NJ) 1991-1992 Noreen Roth, M.D. (Private practice, Santa Rosa, CA; now known as Noreen R. Henig, M.D.) 1992-1995 Susanna Fulmek, M.D. (Dept Medicine, U Vienna, Austria) 1992-1996 Amy Reichlin, M.D. {Asst Prof, Dept Pediatrics (Neonatology), NYU Medical Center, NY} 1993-2000 Michael G. Brown, Ph.D. (Associate Professor, Dept Med, U Virginia, Charlottesville, VA) 1995-1998 Naoki Matsumoto, Ph.D. (Associate Professor, Dept Integrated Sciences, U Tokyo, Tokyo, Japan) 1995-2003 Koho Iizuka, M.D. (Assistant Professor, Cancer Center, U Minnesota, Minneapolis, MN) 1996-2002 Jonathan Heusel, M.D., Ph.D. (Associate Professor, Dept Pathology, U Iowa, Iowa City, IA) 1998-2003 Beatrice Plougastel, Ph.D. (Research Scientist, Washington University) 1998-2000 Jun Zhang, Ph.D. (Hematol Div, Dept Med, WUSM) 1998-1999 Ying Du, M.D. (Rheum Div, U Penn, Philadelphia, PA) 1998-1999 Taro Nagai, M.D. (Research Scholar, Environmental Health, Boston U) 1999-2000 Suellen Greco, D.V.M. (Assistant Professor, Div Comp Med, WUSM) 1999-2002 Hiroshi Furukawa, M.D., Ph.D. (Assistant Professor, Tohoku University, Sendai, Japan) 1999-2003 Sungjin Kim, Ph.D. (Asst Prof, Dept Micro Immunol, Michigan State U, East Lansing, MI) 2000-2004 Leon Carayannopoulos, M.D., Ph.D. (Inflammation R & D, Merck, Rahway, NJ) 2000-2001 Hyunseok (Peter) Kang, M.D. (Assistant Professor and Staff Physician, Dept Pathology and Lab Medicine, Roswell Park Cancer Institute, Buffalo, NY) 2001-2003 Yun-Jeong Song, M.D. (Rheumatology Fellow, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD) 2001-2005 Anthony French, M.D., Ph.D. (Assistant Prof, Dept Ped, WUSM) 2001-2003 Indira Mehta, Ph.D. (Fellow in Human Genetics, HHMI, Univ Calif San Francisco) 2001-2003 Hamish Smith, Ph.D. (Post-doctoral Fellow, Genentech) 2002 Brigitte G. Dorner, Ph.D. (Principal Investigator, Robert Koch Institut, Berlin, Germany) 2002-2008 Sandeep Tripathy, M.D., Ph.D. (Asst Prof, Gastroenterology Div, Dept Med, WUSM) 2003-2004 Kevin Latinis, M.D., Ph.D. (Asst Prof, Rheum Div, Dept Med, U Kansas, Kansas City, KS) 2003-2008 John B. Sunwoo, M.D. (Asst Prof, Dept Otolaryngology, Stanford U, Palo Alto, CA) 2004-2006 Joy Loh, Ph.D. (Lab manager, Dept Pathology Immunology, WUSM) 2005-2009 Paul Klekotka, M.D., Ph.D. (Dermatology R & D, Amgen, Thousand Oaks, CA) 2005-2009 Tammy Cheng, M.D. (Private practice, Ventura, CA) 2005-2009 Taewoong Choi, M.D. (Hematology-Oncology Fellow, U of Pittsburgh, Pittsburgh, PA) 2006-2007 Katrin Wiemann, Ph.D. (Left early due to death in family) 2006-2009 Peter Keyel, Ph.D. (Assistant Professor, Dept Biological Sciences, Texas Tech University, Lubbock, TX 9/2013) 2007-2010 Megan A. Cooper, M.D., Ph.D. (Assistant Professor, Dept Ped, WUSM) 2007-2008 Vladimir Despotovic, M.D. (Pulmonary Fellow, Barnes-Jewish Hospital, St. Louis) 2007-2011 Joseph Wahle, Ph.D. (Staff Scientist, Novo Nordisk, Seattle, WA) 2009-Date Bijal A. Parikh, M.D., Ph.D. 2009-Date Takashi Ebihara, M.D., Ph.D. 2010-Date Maria Gainey, Ph.D. 2011-Date Dorothy K. Sojka, Ph.D. 2011-Date Sytse Piersma, Ph.D. 2012-Date Melissa Pak-Wittel, Ph.D.

Basic Research Sabbatical Training: 2005-2006 Sik Yoon, Ph.D. (on sabbatical from Department of Anatomy, Pusan National University College of Medicine, Pusan, South Korea) 2005-2006 Achim Schneeberger, M.D. (on sabbatical from Department of Dermatology, University of Vienna, Vienna, Austria)

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18. BIBLIOGRAPHY: a. Original Peer-Reviewed Manuscripts:

1. Yokoyama, W.M., and Yokoyama, M.M. Incidence of HL-A antigens in the Japanese male population of Hawaii. Jpnse J Exp Med 1973; 43:81.

2. Foucar, K., Carroll, T.J., Tannous, R., Peterson, L., Goeken, J.A., Binion, S., Gajl-Peczalska, J., and Yokoyama, W.M. Nonendemic adult T cell leukemia/lymphoma in the United States: Report of 2 cases and review of the literature. Am J Clin Pathol 1985; 83:18-26.

3. Chien, M.M., Yokoyama, W.M., and Ashman, R.F. Mitogen-stimulated phospholipid synthesis in normal and immune-deficient B cells. J Immunol 1986; 136:2844-2850.

4. Stingl, G., Gunter, K.C., Tschachler, E., Yamada, H., Lechler, R.I., Yokoyama, W.M., Steiner, G., Germain, R.N., and Shevach, E.M. Thy 1+ dendritic epidermal cells belong to the T cell lineage. Proc Natl Acad Sci (USA) 1987; 84:2430-2434. PMCID: PMC304665

5. Gunter, K.C., Germain, R.N., Kroczek, R.A., Saito, T., Yokoyama, W.M., Chan, C., Weiss, A., and Shevach, E.M. Thy-1 mediated T cell activation requires co-expression of the CD3/Ti complex. Nature 1987; 326:505-507.

6. Stingl, G., Koning, F., Yamada, H., Yokoyama, W.M., Tschachler, E., Bluestone, J.A., Steiner, G., Samelson, L.E., Lew, A.M., Coligan, J.E., and Shevach, E.M. Thy-1+ dendritic epidermal cells express T3 and T cell receptor γ-chain. Proc Natl Acad Sci (USA) 1987; 84:4586-4590. PMCID: PMC305135

7. Koning, F., Stingl, G., Yokoyama, W.M., Yamada, H., Shevach, E.M., and Coligan, J.E. Identification of a T3-associated γ-δ T cell receptor on Thy 1+ dendritic epidermal cell lines. Science 1987; 236:834-837.

8. Yokoyama, W.M., Koning, F., Stingl, G., Bluestone, J.A., Coligan, J.E., and Shevach, E.M. Production of a T cell hybridoma that expresses the T cell receptor γ/δ heterodimer. J Exp Med 1987; 165:1725-1730.

9. Koning, F., Kruisbeek, A.M., Maloy, W.L., Marusic-Galesic, S., Pardoll, D.M., Shevach, E.M., Stingl, G., Valas, R., Yokoyama, W.M., and Coligan, J.E. T cell receptor γ/δ chain diversity. J Exp Med 1988; 167:676-681.

10. Yokoyama, W.M., Chien, M.M., Engardt, S.E., Aguiar, S.S., and Ashman, R.F. Membrane depolarization of human B cells follows stimulation by either anti-µ or B cell growth factor (BCGF), but only anti-µ causes cell volume changes. Hum Immunol 1988; 21:155-164.

11. Yokoyama, W.M., Koning, F., Kehn, P.J., Pereira, G.M.B., Stingl, G., Coligan, J.E., and Shevach, E.M. Characterization of a cell surface expressed disulfide linked dimer involved in T cell activation. J Immunol 1988; 141:369-376.

12. Steiner, G., Koning, F., Elbe, A., Tschachler, E., Yokoyama, W.M., Shevach, E.M., Stingl, G., and Coligan, J.E. Characterization of T cell receptors on resident murine dendritic epidermal T cells. Eur J Immunol 1988; 18:1323-1328.

13. Koning, F., Yokoyama, W.M., Maloy, W.L., Stingl, G., McConnell, T.J., Cohen, D.I., Shevach, E.M., and Coligan, J.E. Expression of Cγ4 T cell receptors and lack of isotype exclusion by dendritic epidermal T cell lines. J Immunol 1988; 141: 2057-2062.

14. Hauser, C., Yokoyama, W.M., and Katz, S.I. Characterization of primary T helper cell activation and T helper cell lines stimulated by hapten-modified, cultured Langerhans’ cells. J Invest Dermatol 1989; 93:649-655.

15. McConnell, T.J., Yokoyama, W.M., Kikuchi, G.E., Einhorn, G.P., Stingl, G., Shevach, E.M., and Coligan, J.E. γ chains of dendritic epidermal T cell receptors are diverse but pair with δ chains in a restricted manner. J Immunol 1989; 142:2924-2931.

16. Maxfield, S.R., Moulder, K., Koning, F., Elbe, A., Stingl, G., Coligan, J.E., Shevach, E.M., and Yokoyama, W.M. Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. Identification and characterization with monoclonal antibodies. J Exp Med 1989; 169:2173-2190.

17. Ferrick, D.A., Sambhara, S.R., Ballhausen, W., Iwamoto, A., Pircher, H., Walker, C.L., Yokoyama, W.M., Miller, R.G., and Mak, T.W. T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice. Cell 1989; 57:483-492.

18. Bettler, B., Hofstetter, H., Rao, M., Yokoyama, W.M., Kilcherr, F., and Conrad, D.H. Molecular structure and expression of the murine lymphocyte low affinity receptor for IgE (FcεRII). Proc Natl Acad Sci (USA) 1989; 86:7566-7570. PMCID: PMC298106

19. Yokoyama, W.M., Jacobs, L.B., Kanagawa, O., Shevach, E.M., and Cohen, D.I. A murine T lymphocyte antigen belongs to a supergene family of Type II integral membrane proteins. J Immunol 1989; 143:1379-1386.

20. Yokoyama, W.M., Kehn, P.J., Cohen, D.I., and Shevach, E.M. Chromosomal location of the Ly-49 (A1, YE1/48) multigene family. Genetic association with the NK1.1 antigen. J Immuno 1990; 145:2353-2358.

21. Roberts, K., Yokoyama, W.M., Kehn, P.J., and Shevach, E.M. The vitronectin receptor serves as an accessory molecule for the activation of a subset of γ/δ T cells. J Exp Med 1991; 173:231-240.

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22. Karlhofer, F.M., and Yokoyama, W.M. Stimulation of murine NK cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2 activated NK cells possess additional specific stimulation pathways. J Immunol 1991; 146:3662-3673.

23. Yokoyama, W.M., Ryan, J.C., Hunter, J.J., Smith, H.R.C., Stark, M., and Seaman, W.E. cDNA cloning of mouse NKR-P1 and genetic linkage with Ly-49: Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol 1991; 147:3229-3236.

24. Karlhofer, F.M., Ribaudo, R.K., and Yokoyama, W.M. MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature 1992; 358:66-70.

25. Ashman, R.F., Schaffer, F.M., Kemp, J.D., Yokoyama, W.M., Zhu, Z.-B., Cooper, M.D., and Volanakis, J.E. Genetic and immunologic analysis of a family containing five patients with common-variable immune deficiency or selective IgA deficiency. J Clin Immunol 1992; 12:406-414.

26. Zumla, A., Marguerie, C., So, A., Yokoyama, W.M., Saito, T., Batchelor, J.R., and Lechler, R.I. Co-expression of human T cell receptor chains with mouse CD3 on the cell surface of a mouse T cell hybridoma. J Immunol Meth 1992; 149:69-76.

27. Ryan, J.C., Turck, J., Niemi, E.C., Yokoyama, W.M., and Seaman, W.E. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol 1992; 149:1631-1635.

28. Sobel, E.S., Yokoyama, W.M., Shevach, E.M., Eisenberg, R.A., and Cohen, P.L. Aberrant expression of the very early activation (VEA) antigen on MRL/Mp-lpr/lpr lymphocytes. J Immunol 1993; 150:673-682.

29. Sykes, M., Harty, M.W., Karlhofer, F.M., Pearson, D.A., Szot, G., and Yokoyama, W.M. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J Exp Med 1993; 178:223-229.

30. Smith, H.R.C., Karlhofer, F.M., and Yokoyama, W.M. The Ly-49 multigene family expressed by IL-2-activated natural killer cells. J Immunol 1994; 153:1068-1079.

31. Daniels, B.F., Karlhofer, F.M., Seaman, W.E., and Yokoyama, W.M. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J Exp Med 1994; 180:687-692.

32. Karlhofer, F.M., Hunziker, R., Reichlin, A., Margulies, D.H., and Yokoyama, W.M. Host MHC class I molecules modulate in vivo expression of a natural killer cell receptor. J Immunol 1994; 153:2407-2416.

33. Daniels, B.F., Nakamura, M.C., Rosen, S.D., Yokoyama, W.M., and Seaman, W.E. Ly-49A, a receptor for H-2Dd has a functional carbohydrate recognition domain. Immunity 1994; 1:785-792.

34. Karlhofer, F.M., Orihuela, M.M., and Yokoyama, W.M. Ly-49 independent NK cell specificity revealed by NK cell clones derived from p53-deficient mice. J Exp Med 1995; 181:1785-1795.

35. Scalzo, A.A., Lyons, P.A., Fitzgerald, N.A., Forbes, C.A., Yokoyama, W.M., and Shellam, G.R. Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly-49 and musNKR-P1. Genomics 1995; 27:435-441.

36. Bot, A., Reichlin, A., Isobe, H., Bot, S., Schulman, J., Yokoyama, W.M., and Bona, C.A. Cellular mechanisms involved in protection and recovery from influenza virus infection in immunodeficient mice. J Virol 1996; 70:5668-5672. PMCID: PMC190532

37. Orihuela, M., Margulies, D.H., and Yokoyama, W.M. The NK cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its MHC class I ligand. Proc Natl Acad Sci (USA) 1996; 93:11792-11797. PMCID: PMC38137

38. Mason, L.H., Anderson, S.K., Yokoyama, W.M., Smith, H.R.C., Winkler-Pickett, R., and Ortaldo, J.R. The Ly-49D receptor activates NK cells. J Exp Med 1996; 184:2119-2128. PMCID: PMC2196364

39. Wang, L., Mehta, I., LeBlanc, P., and Yokoyama, W.M. Cutting Edge. Mouse NK cells express gp49B1, a structural homologue of human killer inhibitory receptors. J Immunol 1997; 158:13-17.

40. Forbes, C.A., Brown, M.G., Cho, R., Shellam, G.R., Yokoyama, W.M., and Scalzo, A.A. The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex (NKC) on mouse chromosome 6. Genomics 1997; 41:406-413.

41. Brown, M.G., Fulmek, S., Matsumoto, K., Cho, R., Scalzo, A.A., Lyons, P.A., and Yokoyama, W.M. A 2 megabase YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics 1997; 42:16-25.

42. Reichlin, A., and Yokoyama, W.M. Natural killer cell proliferation induced by anti-NK1.1 and IL-2. Immunology and Cell Biology 1998; 76:143-152.

43. Kim, S., and Yokoyama, W.M. NK cell granule exocytosis and cytokine production inhibited by Ly-49A engagement. Cell Immunol 1998; 183:106-112.

44. Matsumoto, N., Ribaudo, R.K., Abastado J.-P., Margulies, D.H., and Yokoyama, W.M. The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand. Immunity 1998; 8:245-254.

45. Ho, E.L., Heusel, J.W., Brown, M.G., Matsumoto, K., Scalzo, A.A., and Yokoyama, W.M. Murine Nkg2d and Cd94 are clustered within the natural killer gene complex and are expressed independently in NK cells. Proc Natl Acad Sci (USA) 1998; 95:6320-6325. PMCID: PMC27675

46. Idris, A.H., Iizuka, K., Smith, H.R.C., Scalzo, A.A., and Yokoyama, W.M. Genetic control of natural killing and in vivo tumor elimination by the Chok locus. J Exp Med 1998; 188:2243-2256. PMCID: PMC2212436

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47. Wang, L.L., Blasioli, J., Plas, D.R., Thomas, M.L., and Yokoyama, W.M. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine based inhibitory motif-bearing receptor gp49B. J Immunol 1999; 162:1318-1323.

48. Scalzo, A.A., Brown, M.G., Chu, D.T., Heusel, J.W., Yokoyama, W.M., and Forbes, C.A. Development of intra-natural killer complex (NKC) recombinant and cogenic mouse strains for mapping and functional analysis of NK cell regulatory loci. Immunogenetics 1999; 49:238-241.

49. Diefenbach, A., Schindler, H., Röllinghoff, M, Yokoyama, W.M., and Bogdan, C. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 1999; 284:951-955.

50. Iizuka, K., Chaplin, D.D., Wang, Y., Wu, Q., Pegg, L.E., Yokoyama, W.M., and Fu, Y.-X. Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci (USA) 1999; 96:6336-6340. PMCID: PMC26882

51. Idris, A.H., Scalzo, A.A., and Yokoyama, W.M. Close genetic linkage of Chok with the NKC-linked loci Cd94, Ly49, and Cmv1 on mouse chromosome 6. Immunogenetics 1999; 49:906-908.

52. Chung, D.H., Dorfman, H., Plaksin, D., Natarajan, K., Belyakov, I.M., Hunziker, R., Berzofsky, J.A., Yokoyama, W.M., Mage, M.G., and Margulies, D.H. NK and CTL recognition of a single chain H-2Dd molecule: Distinct sites of H-2Dd interact with NK and TCR. J Immunol 1999; 163:3699-3708.

53. Brown, M.G., Du, Y., Zhang, J., Stoll, J., Yokoyama, W.M., and Scalzo, A.A. Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6. J Immunol 1999; 163: 1991-1999.

54. Idris, A.H., Smith, H.R.C., Mason, L.H., Ortaldo, J.R., Scalzo, A.A., and Yokoyama, W.M. The NKC locus, Chok, encodes Ly49D, a target recognition receptor that activates natural killing. Proc Natl Acad Sci (USA) 1999; 96:6330-6335. PMCID: PMC26881

55. Natarajan, K., Boyd, L.F., Schuck, P., Yokoyama, W.M., Eilat, D., and Margulies, D.H. Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: Identification of a site distinct from the TCR site. Immunity 1999; 11:591-601.

56. Kim, S., Iizuka, K., Aguila, H.L., Weissman, I.L., and Yokoyama, W.M. In vivo natural killer cell activities revealed by natural killer cell-deficient mice. Proc Natl Acad Sci (USA) 2000; 97:2731-2736. PMCID: PMC15998

57. Smith, H.R.C., Chuang, H.C., Wang, L.L., Salcedo, M., Heusel, J.W., and Yokoyama, W.M. Nonstochastic coexpression of activation receptors on murine natural killer cells. J Exp Med 2000; 191:1341-1354. PMCID: PMC2193132

58. Wang, L.L, Chu, D.T., Dokun, A.O., and Yokoyama, W.M. Inducible expression of the gp49B inhibitory receptor on natural killer cells. J Immunol 2000; 164: 5215-5220.

59. Chung, D,H., Natarajan, K., Boyd, L.F., Tormo, J., Mariuzza, R.A., Yokoyama, W.M. and Margulies, D.H. Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J Immunol 2000; 165:6922-6932.

60. Matsumoto, N., Mitsuki, M., Tajima, K., Yokoyama, W.M., and Yamamoto, K. The functional binding site for the C-type lectin-like NK cell receptor Ly49A spans three domains of its MHC class I ligand. J Exp Med 2001; 193:147-157. PMCID: PMC2193338

61. Plougastel, B., Dubbelde, C., and Yokoyama, W.M. Cloning of Clr, a new family of lectin-like genes localized between mouse Nkrp1a and Cd69. Immunogenetics 2001; 53:209-214.

62. Matsumoto, Y., Wang, L.L., Yokoyama, W.M., and Aso, T. Uterine macrophages express the gp49B inhibitory receptor in midgestation. J Immunol 2001; 166:781-786.

63. Mehta, I.K., Smith, H.R.C., Wang, J., Margulies, D.H., and Yokoyama, W.M. A “chimeric” C57L-derived Ly49 inhibitory receptor resembling the Ly49D activation receptor. Cell Immunol 2001; 209:29-41.

64. Matsumoto, N., Yokoyama, W.M., Kojima, S., and Yamamoto, K. The NK cell MHC class I receptor Ly49A detects mutations on H-2Dd inside and outside of the peptide binding groove. J Immunol 2001; 166:4422-4428.

65. Mehta, I.M., Wang, J., Roland, J., Margulies, D.H., and Yokoyama, W.M. Ly49A allelic variation and MHC class I specificity. Immunogenetics 2001; 53:572-583.

66. Martin, S.M., Mehta, I.K., Yokoyama, W.M., Thomas, M.L., and Lorenz, R.G. Development of intestinal intraepithelial lymphocytes, natural killer cells, and natural killer 1.1+ T cells in CD45 deficient mice. J Immunol 2001; 166:6066-6073.

67. Plougastel, B.F.M., Matsumoto, K., Dubbelde, C., and Yokoyama, W.M. Analysis of a 1 megabase BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Immunogenetics 2001; 53:592-598.

68. Blazar, B.R., Lindberg, F.P., Ingulli, E., Panoskaltsis-Mortari, A., Oldenborg, P.-A., Iizuka, K., Yokoyama, W.M., and Taylor, P.A. CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med 2001; 194:541-549. PMCID: PMC2193501

69. Brown, M.G., Dokun, A.O., Heusel, J.W., Smith, H.R.C., Beckman, D.L., Blattenberger, E.A., Dubbelde, C.E., Stone, L.R., Scalzo, A.A., and Yokoyama, W.M. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 2001; 292:934-937.

Page 26 CV: Yokoyama

70. Dokun, A.O., Kim, S., Smith, H.R.C., Kang, H.-S.P., Chu, D.T., and Yokoyama, W.M. Specific and non-specific NK cell activation during virus infection. Nature Immunol 2001; 2:951-956.

71. Brown, M.G., Scalzo, A.A., Stone, L.R., Clark, P.Y., Du, Y., Palanca, B., and Yokoyama, W.M. Nkc allelic variability among inbred mouse strains: Evidence for Nkc haplotypes. Immunogenetics 2001; 53:584-591.

72. Dokun, A.O., Chu, D.T., Yang, L., Bendelac, A.S., and Yokoyama, W.M. Analysis of in situ NK cell responses during viral infection. J Immunol 2001; 167:5286-5293.

73. Carayannopoulos, L.N., Naidenko, O.V., Kinder, J., Ho, E.L., Fremont, D.H., and Yokoyama, W.M. Ligands for murine NKG2D display heterogeneous binding behavior. Eur J Immunol 2002; 32:597-605.

74. Kim, S., Iizuka, K., Kang, H.-S.P., Dokun, A., French, A.R., Greco, S., and Yokoyama, W.M. In vivo developmental stages in murine natural killer cell maturation. Nature Immunol 2002, 3:523-528.

75. Furukawa, H., Iizuka, K., Poursine-Laurent, J., Shastri, N., and Yokoyama, W.M. A ligand for the murine NK activation receptor Ly49D: Activation of tolerized NK cells from β2-microglobulin-deficient mice. J Immunol 2002; 169:126-136.

76. Smith, H.R.C., Heusel, J.W., Mehta, I.K., Kim, S., Dorner, B.G., Naidenko, O.V., Iizuka, K., Furukawa, H., Beckman, D.L., Pingel, J.T., Scalzo, A.A., Fremont, D.H., and Yokoyama, W.M. Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci (USA) 2002; 99:8826-8831. PMCID: PMC124383

77. Ho, E.L., Carayannopoulos, L.N., Poursine-Laurent, J., Kinder, J., Plougastel, B., Smith, H.R.C., and Yokoyama, W.M. Costimulation of multiple NK cell activation receptors by NKG2D. J Immunol 2002; 169:3667-3675.

78. Carayannopoulos, L.N., Naidenko, O.V., Fremont, D.H., and Yokoyama, W.M. Cutting Edge: Murine UL16 binding protein-like transcript 1: A newly described transcript encoding a high affinity ligand for murine NKG2D. J Immunol 2002; 169:4079-4083.

79. Gilfillan, S., Ho, E.L., Cella, M., Yokoyama, W.M., and Colonna, M. NKG2D recruits two distinct adapters to trigger natural killer cell activation and costimulation. Nature Immunol 2002; 3:1150-1155.

80. Kaifu, T., Nakahara, J., Mishima, K. Kaji, M., Inui, M., Ujike, A., Tan-Takeuchi, K., Iwasaki, K., Yokoyama, W.M., Fujiwara, M., Asou, H., and Takai, T. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest 2003; 111:323-332. PMCID: PMC151867

81. Andrews, D.M., Scalzo, A.A., Yokoyama, W.M., Smyth, M.J., and Degli-Esposti, M.A. Functional interactions between dendritic cells and NK cells during viral infection. Nature Immunol 2003; 4:175-181.

82. Backström, E., Chambers, B.J., Ho, E.L., Naidenko, O.V., Mariotti, R., Fremont, D.H., Yokoyama, W.M., Kristensson, K., and Ljunggren, H.-G. Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions. Eur J Immunol 2003; 33:92-100.

83. Gu, X., Laouar, A., Wan, J., Daheshia, M., Lieberman, J., Yokoyama, W.M., Katz, H.R., and Manjunath, N. The gp49B1 inhibitory receptor regulates the IFN-γ responses of T cells and NK cells. J Immunol 2003; 170:4095-4101.

84. Iizuka, K., Naidenko, O.V., Plougastel, B.F.M., Fremont, D.H., and Yokoyama, W.M. Genetically linked C-type lectin-related ligands for the Nkrp1 family of NK cell receptors. Nature Immunol 2003; 4:801-807.

85. Scalzo, A.A., Wheat, R., Dubbelde, C., Stone, L., Clark, P., Du, Y., Dong, N., Stoll, J., Yokoyama, W.M., and Brown, M.G. Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus. Immunogenetics 2003; 55:370-378.

86. Voigt, V., Forbes, C.A., Tonkin, J.N., Degli-Esposti, M.A., Smith, H.R.C., Yokoyama, W.M., and Scalzo, A.A. Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells. Proc Natl Acad Sci (USA) 2003; 100:13483-13488. PMCID: PMC263840

87. Dorner, B.G., Smith, H.R.C., French, A.R., Kim, S., Poursine-Laurent, J., Beckman, D.L., Pingel, J.T., Kroczek, R.A., and Yokoyama, W.M. Coordinate expression of cytokines and chemokines by natural killer cells during murine cytomegalovirus infection. J Immunol 2004, 172:3119-3131.

88. Whitman, S.C., Rateri, D.L., Szilvassy, S.J., Yokoyama, W., Daugherty, A. Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Atheroscler Thromb Vasc Biol 2004; 24:1-7.

89. French, A.R., Pingel, J.T., Wagner, M., Bubic, I., Yang, L., Kim, S., Koszinowski, U., Jonjić, S., and Yokoyama, W.M. Escape of mutant double-stranded DNA virus from innate immune control. Immunity 2004; 20:747-756.

90. Warfield, K.L., Perkins, J.G., Swenson, D.L., Deal, E.M., Bosio, C.M., Aman, M.J., Yokoyama, W.M., Young, H.A., and Bavari, S. Role of natural killer cells in innate protection against lethal Ebola virus infection. J Exp Med 2004; 200:169-179. PMCID: PMC2212007

91. Bubić, I., Wagner, M., Krmpotić, A., Saulig, T., Kim, S., Yokoyama, W.M., Jonjić, S., and Koszinowski, U.H. Gain-of-virulence caused by loss of a gene in murine cytomegalovirus. J Virol 2004; 78:7536-7544. PMCID: PMC434107

Page 27 CV: Yokoyama

92. Cella, M., Fujikawa, K., Tassi, I., Kim, S., Latinis, K., Nishi, S., Yokoyama, W., Colonna, M., and Swat, W. Differential requirements of Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J Exp Med 2004; 200:817-823. PMCID: PMC2211968

93. Krug, A., French, A.R., Barchet, W., Fischer, J.A.A., Dzionek, A., Pingel, J.T., Orihuela, M., Akira, S., Yokoyama, W.M., and Colonna, M. TLR9-dependent recognition of murine cytomegalovirus (MCMV) by interferon-producing cells and dendritic cells generates a coordinated cytokine response that activates anti-viral NK cell function. Immunity 2004; 21:107-119.

94. Smyth, M.J., Swann, J., Kelly, J.M., Cretney, E., Yokoyama, W.M., Diefenbach, A., Sayers, T.J., and Hayakawa, Y. NKG2D recognition and perforin effector function mediates effective cytokine immunotherapy of cancer. J Exp Med 2004; 200:1325-1335. PMCID: PMC2211920

95. Westgaard, I.H., Berg, S.F., Vaage, J.T., Wang, L.L., Yokoyama, W.M., Dissen, E., and Fossum, S. Rat Nkp46 activates natural killer cell cytotoxicity and is associated with FcεRIγ and CD3ζ. J Leukoc Biol 2004; 76:1200-1206.

96. Loh, J., Chu, D.T., O’Guin, A.K., Yokoyama, W.M., and Virgin IV, H.W. Natural killer cells utilize both perforin and IFNγ to regulate murine cytomegalovirus infection in spleen and liver. J Virol 2005; 79:661-667. PMCID: PMC538682

97. Tassi, I., Presti, R., Kim, S., Yokoyama, W.M., Gilfillan, S., and Colonna, M. Phospholipase C-γ2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol 2005; 175:749-754.

98. French, A.R., Pingel, J.T., Kim, S., Yang, L. and Yokoyama, W.M. Rapid emergence of escape mutants following infection with murine cytomegalovirus in immunodeficient mice. Clin Immunol 2005; 115:61-69.

99. Kriegeskorte, A.K., Gebhardt, F.E., Porcellini, S., Schiemann, M., Stemberger, C., Franz, T.J., Carayannopoulos, L.N., Yokoyama, W.M., Colonna, M., Siccardi, A.G., Bauer, S., and Busch, D.H. NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc Natl Acad Sci (USA) 2005; 102:11805-11810. PMCID: PMC1187963

100. Kim, S., Poursine-Laurent, J., Truscott, S.M., Lybarger, L., Song, Y.-J., Yang, L., French, A.R., Sunwoo, J.B., Lemieux, S., Hansen, T.H., and Yokoyama, W.M. Licensing of natural killer cells by host MHC class I. Nature 2005; 436:709-713.

101. Smyth, M.J., Swann, J., Cretney, E., Zerafa, N., Yokoyama, W.M., and Hayakawa, Y. NKG2D function protects the host from tumor initiation. J Exp Med 2005; 202:583-588. PMCID: PMC2212868

102. Wiemann, K., Mittrücker, H.-W., Feger, U., Welte, S.A., Yokoyama, W.M., Spies, T., Rammensee, H.G., and Steinle, A. Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J Immunol 2005; 175:720-729.

103. Markiewicz, M.A., Carayannopoulos, L.N., Naidenko, O.V., Matsui, K., Burack, W.R., Wise, E.L., Fremont, D.H., Allen, P.M,. Yokoyama, W.M., Colonna, M., Shaw, A.S. Costimulation through NKG2D enhances murine CD8+ CTL function: Similarities and differences between NKG2D and CD28 costimulation. J Immunol 2005; 175:2825-2833.

104. Tripathy, S.K., Smith, H.R.C., Holroyd, E.A., Pingel, J.T., and Yokoyama, W.M. Expression of m157, a murine cytomegalovirus-encoded putative MHC class I-like protein, is independent of viral regulation of host MHC class I. J Virol 2006; 80:545-550. PMCID: PMC1317552

105. Bui, J.D., Caryannopoulos, L.N., Lanier, L.L., Yokoyama, W.M., and Schreiber, R.D. IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. J Immunol 2006; 176:905-913.

106. Kim, S., Song, Y.-J., Higuchi, D.A., Kang, H.P., Pratt, J.R., Yang, L., Hong, C.M., Poursine-Laurent, J., Iizuka, K., French, A.R., Sunwoo, J.B., Ishii, S., Reimold, A.M., and Yokoyama, W.M. Arrested natural killer cell development associated with transgene insertion into the Atf2 locus. Blood 2006; 107:1024-1030. PMCID: PMC1458371

107. Abdool, K., Cretney, E., Brooks, A.D., Kelly, J.M., Swann, J., Shanker, A., Bere, E.W. Jr., Yokoyama, W.M., Ortaldo, J.R., Smyth, M.J., and Sayers, T.J. NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function. J Immunol 2006; 177:2575-2583.

108. French, A.F., Sjölin, H., Kim, S., Koka, R., Yang, L., Young, D.A., Cerboni, C., Tomasello, E., Ma, A., Vivier, E., Kärre, K., and Yokoyama, W.M. DAP12 signaling directly augments pro-proliferative cytokine stimulation of NK cells during viral infection. J Immunol 2006; 177:4981-4990.

109. French, A.R., Holroyd, E.B., Yang, L., Kim, S., and Yokoyama, W.M. IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation. Cytokine 2006; 35:229-234.

110. Parker, A.K., Parker, S., Yokoyama, W.M., Corbett, J.A., and Buller, R.M.L. Induction of natural killer cell responses by ectromelia virus controls infection. J Virol 2007; 81:4070-4049. PMCID: PMC1866162

111. Campbell, J.A., Trossman, D.S., Yokoyama, W.M., and Carayannopoulos, L.N. Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D. J Exp Med 2007; 204:1311-1317. PMCID: PMC2118624

112. French, A.R., Kim, S., Fehniger, T.A., Pratt, J.R., Yang, L., Song, Y.J., Caligiuri, M.A., and Yokoyama, W.M. Chronic lymphocytosis of functionally immature NK cells. J Aller Clin Immunol 2007; 120:924-931.

Page 28 CV: Yokoyama

113. Divangahi, M., Yang, T. Kugathasan, K., McCormick, S., Takenaka, S. Gaschler, G., Ashkar, A., Stampfli, M., Gauldie, J., Bramson, J., Takai, T., Brown, E., Yokoyama, W.M., Aoki, N., and Xing, Z. Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection. J Immunol 2007; 179:4015-4026.

114. Yu, J., Heller, G., Chewning, J., Kim, S., Yokoyama, W.M., and Hsu, K.C. Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. J Immunol 2007; 179:5977-5989.

115. Byun, M., Wang, X., Pak, M., Hansen, T.H., and Yokoyama, W.M. Cowpox virus exploits KDEL retrieval pathway to evade MHC class I biosynthesis. Cell Host Microbe 2007; 2:306-315.

116. Choi, B.K., Kim, Y.H., Kang, W.J., Lee, S.K., Kim, K.H., Shin, S.M., Yokoyama, W.M., Kim, T.Y., and Kwon, B.S. Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res 2007; 67:8891-8899.

117. Parker, A.K., Yokoyama, W.M., Corbett, J.A., Chen, N., and Buller, R.M.L. Primary naïve and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication. J Gen Virol 2008; 89:751-759.

118. Iizuka, K., Scalzo, A.A., Xian, H., and Yokoyama, W.M. Regulation of NK cell allo-reactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol 2008; 180:3260-3267.

119. Kim, S., Sunwoo, J.B., Yang, L., Choi, T., Song, Y.-J., French, A.R., Vlahiotis, A., Piccirillo, J.F., Cella, M., Colonna, M., Mohanakumar, T., Hsu, K.C., Dupont, B., and Yokoyama, W.M. HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci (USA) 2008; 105:3053-3058. PMCID: PMC2268583

120. Bekiaris, V., Timoshenko, O., Hous, T.Z., Toellner, K., Shakib, S., Gaspal, F., McConnell, F.M., Parnell, S.M., Withers, D., Buckley, C.D., Sweet, C., Yokoyama, W.M., Anderson, G., and Lane, P.J.L. Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection. J Immunol 2008; 180:6768-6776.

121. Gross, O., Grupp, C., Steinberg, C., Zimmermann, S., Strasser, D., Hannesschläger, N., Reindl, W., Jonsson, H., Huo, H., Littman, D.R., Peschel, C., Yokoyama, W.M., Krug, A., and Ruland, J. Multiple ITAM-coupled NK cell receptors engage the Bcl10/MALT1 complex via CARMA1 for NK-κB and MAPK activation to selectively control cytokine production. Blood 2008; 112:2421-2428. PMCID: PMC2532811

122. Tripathy, S.K., Keyel, P.A., Yang, L., Pingel, J.T., Cheng, T.P., Schneeberger, A., and Yokoyama, W.M. Continuous engagement of self-specific activation receptors induces NK cell tolerance. J Exp Med 2008; 205:1829-1841. PMCID: PMC2525593

123. Sunwoo, J.B., Kim, S., Yang, L., Naik, T., Higuchi, D.A., Rubenstein, J.L., and Yokoyama, W.M. Distal-less homeobox transcription factors regulate development and maturation of natural killer cells. Proc Natl Acad Sci (USA) 2008; 105:10877-10882. PMCID: PMC2504821

124. Cheng, T.P., French, A.R., Plougastel, B.F.M., Pingel, J.T., Orihuela, M.M., Buller, R.M.L., and Yokoyama, W.M. Ly49h is necessary for genetic resistance to murine cytomegalovirus. Immunogenetics 2008; 60:565-573. PMCID: PMC2730736

125. van den Broeck, T., Stevenaert, F., Taveirne, S., Debackder, V., Vangesel, C., Vandekerckhove, B., Taghon, T., Matthys, P., Plum, J., Held, W., Dewerchin, M., Yokoyama, W.M., and Leclercq, G. Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. Blood 2008; 112:5046-5051.

126. Hsu, K.M., Pratt, J.R., Akers, W.J., Achilefu, S.I., and Yokoyama, W.M. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J Gen Virol 2009; 90:33-43. PMCID: PMC2762738

127. Cooper, M.A., Elliott, J.M., Keyel, P.A., Yang, L., Carrero, J.A., and Yokoyama, W.M. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci (USA) 2009; 106:1915-1919. PMCID: PMC2644138

128. Tassi, I., Le Friec, G., Gilfillan, S., Takai, T., Yokoyama, W.M., and Colonna, M. DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo. Eur J Immunol 2009: 39:1129-1135. PMCID: PMC3128836

129. Zafirova, B., Mandarić, S., Antulov, R., Krmpotić, A., Jonsson, A.H., Yokoyama, W.M., Jonjić, S., and Polic, B. Altered NK cell development and enhanced NK cell-mediated resistance to MCMV in NKG2D-deficient mice. Immunity 2009; 31:270-282. PMCID: PMC2782462

130. Rouhi, A., Lai, C.B., Cheng, T.P., Takei, F., Yokoyama, W.M., and Mager, D.L. Evidence for high bi-allelic expression of activating Ly49 receptors. Nucleic Acids Res 2009; 37:5331-5342. PMCID: PMC2760814.

131. Byun, M., Verweij, M.C., Pickup, D.J., Wiertz, E.J.H.J., Hansen, T.H. and Yokoyama, W.M. Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. Cell Host Microbe 2009; 6:422-432. PMCID: PMC2791900

132. Klekotka, P.A., Yang, L., and Yokoyama, W.M. Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity. J Invest Derm 2010; 130:184-191. PMCID: PMC2795006

133. Cheng, T.P., Valentine, M.C., Gao, J., Pingel, J.T. and Yokoyama, W.M. Stability of murine cytomegalovirus genome after in vitro and in vivo passage. J Virol 2010; 84:2623-2628. PMCID: PMC2820925

Page 29 CV: Yokoyama

134. Jonsson, A.H., Yang, L., Kim, S., Taffner, S.M. and Yokoyama, W.M. Effects of MHC class I alleles on licensing of Ly49A+ NK cells. J Immunol 2010; 184:3424-3432. PMCID: PMC2862662

135. Higuchi, D.A., Cahan, P., Gao, J., Ferris, S.T., Poursine-Laurent, J., Graubert, T.A., and Yokoyama, W.M. Structural variation of the mouse natural killer gene complex. Genes and Immunity 2010; 11:637-648. PMCID: PMC2995812

136. Elliott, J.M., Wahle, J.A., and Yokoyama, W.M. MHC-class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment. J Exp Med 2010; 207:2073-2079. PMCID: PMC2947074

137. Carayannopoulos, L.N., Barks, J.L., Yokoyama, W.M., and Riley, J.K. Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1. Biology of Reproduction 2010; 83:404-414. PMCID: PMC2924803

138. Choi, T., Ferris, S.T., Matsumoto, N., Poursine-Laurent, J., and Yokoyama, W.M. Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands. J Immunol 2011; 186:3911-3917. PMCID: PMC3082152

139. Keyel, P.A., Loultcheva, L., Roth, R., Salter, R.D., Watkins, S.C., Yokoyama, W.M., and Heuser, J.E. Streptolysin O clearance via sequestration into blebs that bud passively from the plasma membrane. J Cell Sci 2011; 124:2414-2423. PMCID: PMC3124372

140. Vargas, C.L., Poursine-Laurent, J., Yang, L. and Yokoyama, W.M. Development of thymic NK cells from double negative 1 thymocyte precursors. Blood 2011;118:3570-3578. PMCID: PMC3186333

141. Pinto, A.K., Daffis, S., Brien, J.D., Gainey, M.D., Yokoyama, W.M., Sheehan, K.C.F., Murphy, K.M., Schreiber, R.D., and Diamond, M.S. A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection. PLoS Pathogens 2011; 7:e1002407. PMCID: PMC3228803

142. Szretter, K.J., Daniels, B.P., Cho, H., Gainey, M.D., Yokoyama, W.M., Gale, M., Virgin, H.W., Klein, R.S., Sen, G.C., and Diamond, M.S. 2’-O methylation of the viral mRNA cap by West Nile Virus evades Ifit1-dependent and –independent mechanisms of host restriction in vivo. PLoS Pathogens 2012;8:e1002698. PMCID: PMC3349756.

143. Kreisel, D., Gelman, A.E., Higashikubo, R., Lin, X., Vikis, H.G., White, J.M., Toth, K.A., Despande, C., Carreno, B.M., You, M., Taffner, S.M., Yokoyama, W.M., Bui, J.D., Schreiber, R.D., and Krupnick, A.S. Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer. Cancer Research 2012;72:4311-4317. PMC Journal – In Process.

144. PNAS Plus: Gainey, M.D., Rivenbark, J.G., Cho, H., Yang, L., and Yokoyama, W.M. Viral MHC class I inhibition evades CD8+ T cell effector responses in vivo but not CD8+ T cell priming. Proc Natl Acad Sci (USA) 2012; 109:E3620-3267. PMCID: PMC3511129.

145. Andrews, D.M., Sullivan, L.C., Baschuk, N., Chan, C.J., Berry, R., Cotterell, C.I., Lin, J., Halse, H., Watt, S.V., Poursine-Laurent, J., Wang, C.-R., Scalzo, A.A., Yokoyama, W.M., Rossjohn, J., Brooks, A.G., and Smyth, M.J. Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nature Immunology 2012; 13:1171. PMC Journal – In Process.

145. McCoy, W.L. IV, Wang, X., Yokoyama, W.M., Hansen, T.H., and Fremont, D.H. Structural mechanism of ER retrieval of MHC class I by cowpox. PLoS Biology 2012;10:e1001432. PMCID: PMC3507924.

146. Sauer, K., Park, E., Siegemund, S., French, A.F, Wahle, J.A., Sternberg, L., Rigaud, S., Jonsson, A.H. Yokoyama, W.M. and Huang, Y.H. Inositol tetrakisphosphate limits NK cell effector functions by controlling phophoinositide 3-kinase signaling. Blood 2013;121:286-97. PMC Journal – In Process.

147. PNAS Plus: Pak-Wittel, M.A., Yang, L., Sojka, D.K., Rivenbark, J.G., and Yokoyama, W.M. Interferon-γ mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci (USA) 2013;110:E50-9. PMCID: PMC3538256.

148. Peng, H., Jiang, X., Chen, Y., Sojka, D.K., Wei, H., Gao, X., Sun, R., Yokoyama, W.M., and Tian, Z. CD49a+ DX5– NK cells are liver-resident NK cells that confer adaptive immunity in skin-contact inflammation. J Clin Invest 2013;123:1444-1456. PMCID: PMC3613925.

149. Keyel, P.A., Roth, R., Yokoyama, W.M., Heuser, J.E., and Salter, R.D. Reduction of streptolysin O (SLO) pore-forming activity enhances inflammasome activation. Toxin 2013;5:1105-1118.

150. Chapa, T.J., Johnson, L.S., Affolter, C., Valentine, M.C., Fehr, A.R., Yokoyama, W.M., and Yu, D. Murine cytomegalovirus protein pM79 is a key regulator for viral late transcription. J Virol 2013;87:9135-9147.

151. PNAS Plus: Ebihara, E., Jonsson, A.H., and Yokoyama, W.M. NK cell licensing in mice with inducible expression of MHC class I. Proc Natl Acad Sci (USA) 2013; E4232-E4237.

152. Jakubzick, C., Gautier, E.L., Gibbings, S.L., Sojka, D.K., Schlitzer, A., Johnson, T.E., Ivanov, S., Duan, Q., Bala, S., Condon, T., van Rooijen, N., Grainger, J.R., Belkaid, Y., Ma’ayan, A., Riches, D.W.H., Yokoyama, W.M., Ginhoux, F., Henson, P.H., and Randolph, G.J. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity 2013;39:599-610.

153. Schoggins, J.W., MacDuff, D., Imanaka, N., Gainey, M.D., Eitson, J., Mar, K.B., Richardson, R.B., Dabelic, R., Litvak, V., Ratshny, A.V., Manicassamy, B., Aitchison, J.D., Aderem, A., Elliott, R.M., Garcia-Sastre, A., Racaniello, V., Snijder, E.J., Yokoyama, W.M., Diamond, M.S., Virgin, H.W., and Rice, C.M. Selective viral

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targeting by interferon effectors points to a requirement for cGAS in antiviral immunity. Nature 2013; in press.

b. Invited publications:

1. Dohi, Y., Yamakido, M., Yokoyama, W.M., and Yokoyama, M.M. Histocompatibility antigens (HL-A) and disease: a review. Hiroshima J Med Sci 1974; 23:1-17.

2. Coligan, J.E., Koning, F., Yokoyama, W.M., Lew, A.M., Maloy, W.L., Stingl, G., and Shevach, E.M. Identification and biochemical characterization of γ-chain T cell receptors on Thy-1+ dendritic epidermal cell lines. In The T-Cell Receptor (Kappler, J., and Davis, M., Eds.). Alan R. Liss, Inc., 1988; Pages 47-56.

3. Coligan, J.E., Koning, F., Lew, A.M., Maloy, W.L., Yokoyama, W.M., Stingl, G., and Shevach, E.M. γ-chain T cell receptors on dendritic epidermal cells. In Lymphocyte Activation and Differentiation (Mani, J.C. and Dornand, J., Eds.). New York: W. de Gruyter and Co., 1988; pp. 533-536.

4. Koning, F., Yokoyama, W.M., Stingl, G., Cohen, D., Shevach, E.M., and Coligan, J.E. Diversity of γδT-cell receptors expressed by dendritic epidermal cell lines. In Molecular Basis of the Immune Response (Bona, C., Ed.). Ann NY Acad Sci 1988; 546:201.

5. Pereira, G.M.B., Furtaldo, G. de C., Yokoyama, W.M., Kipnis, T.L., and Shevach, E.M. Comparative aspects of T cell activation in vivo following stimulation with anti-CD3 mAb, allogeneic cells, and Trypanosoma cruzi. Mem Inst Oswaldo Cruz 1988; 83:284-290.

6. Yokoyama, W.M., and Shevach, E.M. T cell activation via cell-surface antigens other than the CD3/T cell receptor complex. The Year in Immunology, 1988. 1989; 4:110-146.

7. Yokoyama, W.M., Maxfield, S.R., and Shevach, E.M. Very early (VEA) and very late (VLA) activation antigens have distinct functions in T lymphocyte activation. Immunol Rev 1989; 109:153-176.

8. Yokoyama, W.M. Unit 2.5, Production of monoclonal antibodies. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 1991.

9. Yokoyama, W.M. Unit 2.6, Monoclonal antibody supernatant and ascites fluid production. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 1991.

10. Yokoyama, W.M. Unit 5.4, Flow cytometric analysis using the Becton Dickinson FACScan. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 1991.

11. Fitch, F.W., Gajekski, T.F., and Yokoyama, W.M. Appendix 3E, Diagnosis and treatment of mycoplasma-contaminated cell cultures. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 1991.

12. Yokoyama, W.M. Appendix 3G, Cryopreservation of cells. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 1991.

13. Yokoyama, W.M. Unit 11.11, Production of monoclonal antibody supernatant and ascites fluids. In Current Protocols in Molecular Biology, (Ausubel, F.M., Brent, R.., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K., Eds.). New York: Greene Publishing, 1992.

14. Otten, G., Yokoyama, W.M. Flow cytometry analysis using the Becton Dickinson FACScan and Lysys II software. In Current Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing. 1992.

15. Karlhofer, F.M., Ribaudo, R.K., and Yokoyama, W.M. The interaction of Ly-49 with H-2Dd globally inactivates NK cell cytolytic activity. Trans Assoc Amer Physicians 1992; 105:72-85.

16. Yokoyama, W.M. Recognition structures on natural killer cells. Curr Opin Immunol 1993; 5:67-73. 17. Yokoyama, W.M., and Seaman, W.E. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on

natural killer cells: The NK gene complex. Ann Rev Immunol 1993; 11:613-635. 18. Yokoyama, W.M., Smith, H.R.C., and Karlhofer, F.M. The Ly-49 family of putative NK cell receptors specific

for target cell MHC class I molecules. In MHC Antigens and NK Cells (Solana, R., Peña, J., Eds.). Austin, TX: R.G. Landes, 1994; p. 68-90.

19. Yokoyama, W.M., Daniels, B.F., Seaman, W.E., Hunziker, R., Margulies, D.H., and Smith, H.R.C. A family of murine NK cell receptors specific for target cell MHC class I molecules. Sem Immunol 1995; 7:89-101.

20. Yokoyama, W.M. Natural killer cell receptors. Curr Opin Immunol 1995; 7:110-120. 21. Yokoyama, W.M. Review. Natural killer cell receptors specific for major histocompatibility class I

molecules. Proc Natl Acad Sci (USA) 1995; 92:3081-3085. PMCID: PMC42108 22. Yokoyama, W.M. Commentary. Hybrid resistance and the Ly-49 family of natural killer cell receptors. J

Exp Med 1995; 182:273-277. 23. Yokoyama, W.M. Right-side-up and up-side-down NK cell receptors. Curr Biol 1995; 5:982-985.

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24. Yokoyama, W.M. Chapter 65. Natural killer cells and the NK gene complex. In Weir’s Handbook of Experimental Immunology, Fifth Edition (Herzenberg, L.A., Weir, D.M., Herzenberg, L.A., Blackwell, C., Eds.). London: Blackwell, 1996. Vol 2:65.1-65.21.

25. Yokoyama, W.M., Reichlin, A., Margulies, D.H., and Smith, H.R.C. MHC-class I-dependent and -independent NK cell specificity. In Molecular basis of NK cell recognition and function (Moretta, L., Ed.). Chem Immunol (formerly Prog Allergy) 1996; 64:1-18.

26. Brown, M.G., Scalzo, A.A., Matsumoto, K., and Yokoyama, W.M. The natural killer gene complex: A basis for understanding NK cell function and innate immunity. Immunol Rev 1997; 155:53-65.

27. Yokoyama, W.M., Matsumoto, K., Scalzo, A.A., and Brown, M.G. Molecular genetics of the NK gene complex and innate immunity. Biochem Soc Trans 1997; 25:691-695.

28. Yokoyama, W.M. Commentary. The mother-child union: The case of missing-self and protection of the fetus. Proc Natl Acad Sci (USA) 1997; 94:5998-6000. PMCID: PMC33675

29. Yokoyama, W.M. Commentary. What goes up must come down. The emerging spectrum of inhibitory receptors. J Exp Med 1997; 186:1803-1808. PMCID: PMC2199159

30. Wang, L.L., and Yokoyama, W.M. Regulation of mouse NK cells by structurally divergent inhibitory receptors. Curr Topics Microbiol Immun 1998; 230:3-13.

31. Yokoyama, W.M. Commentary. HLA class I specificity for natural killer cell receptor CD94/NKG2A: Two for one in more ways than one. Proc Natl Acad Sci (USA) 1998; 95:4791-4794. PMCID: PMC33852

32. Yokoyama, W.M. Natural killer cell receptors. Curr Opin Immunol 1998; 10:298-305. 33. Yokoyama, W.M. Chapter 17. Natural killer cells. In Paul, W.E. (Ed.) Fundamental Immunology (Fourth

Edition), Lippincott-Raven, New York. 1999; p. 575-603. 34. Reichlin, A., Iizuka, K., and Yokoyama, W.M. Unit 3.22. Isolation of murine natural killer cells. In Current

Protocols in Immunology (Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. and Strober, W., Eds.). New York: Greene Publishing, 2000.

35. Brown, M.G., Scalzo, A., and Yokoyama, W.M. The NKC and regulation of natural killer cell-mediated immunity. In Major histocompatilibity complex: Evolution, structure, and function (Kasahara, M., Ed.). Tokyo: Springer-Verlag 2000; p. 287-301

36. Yokoyama, W.M. Now you see it, now you don’t! (News and Views) Nature Immunol 2000; 1:95-97. 37. Wang, L.L. and Yokoyama, W.M. Regulated expression of non-polymorphic gp49 molecules on murine

natural killer cells. In Activating and Inhibitory Immunoglobulin-Like Receptors (Cooper, M.D., Takai, T., Ravetch, J.V., Eds.) Tokyo: Springer-Verlag, 2001; p. 17-31.

38. Smith, H.R.C., Idris, A.H., and Yokoyama, W.M. Murine natural killer cell activation receptors. Immunol Rev 2001; 181:115-125.

39. Matsumoto, N., Mitsuki, M., Tajima, K., Yokoyama, W.M., and Yamamoto, K. Identification of the functional recognition site on MHC class I for an NK cell lectin-like receptor. In Activating and Inhibitory Immunoglobulin-Like Receptors (Cooper, M.D., Takai, T., Ravetch, J.V., Eds.) Tokyo: Springer-Verlag, 2001; p. 215-223.

40. Yokoyama, W.M. Natural killer cells in innate immunity to infection. In Innate Immunity (Ezekowitz, R.A.B.,and Hoffmann, J., Eds.). Totowa, NJ: Humana Press, 2002; pg 321-339.

41. Siva, C., Yokoyama, W.M., McLeod, H.L. Pharmacogenetics in rheumatology: The prospects and limitations of an emerging field. Rheumatology 2002; 41:1273-1279.

42. Yokoyama, W.M. The search for the missing “missing-self” receptor on natural killer cells. Scand J Immunol 2002; 55:233-237. (Novartis Award lecture.)

43. Yokoyama, W.M., and Scalzo, A.A. Natural killer cell activation receptors in innate immunity to infection. Microbes and Infection 2002; 15:1513-1521.

44. Yokoyama, W.M. News and views: Immunology: Catch us if you can. Nature 2002; 419:679-680. 45. Ranganathan, P., Eisen, S., Yokoyama, W.M., and McLeod, H.L. Will pharmacogenetics allow better

prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis? Ann Rheum Dis 2003; 62:4-9. PMCID: PMC1754300

46. French, A.R., and Yokoyama, W.M. Natural killer cells and viral infection. Curr Opin Immunol 2003; 15:45-51.

47. Yokoyama, W.M., and Plougastel, B.F.M. Immune functions encoded by the natural killer gene complex. Nature Rev Immunol 2003; 3:304-316.

48. Yokoyama, W.M. Innate natural killer cell responses to infection. In The Innate Immune Response to Infection (Kaufmann, S.E., Medzhitov, R., and Gordon, S., Eds.) Philadelphia, PA: American Society for Microbiology Press, 2004; pg 133-155.

49. Yokoyama, W.M., Kim, S., and French, A.R. The dynamic life of natural killer cells. Ann Rev Immunol, 2004; 22:405-429.

50. Carayannopoulos, L.N., and Yokoyama, W.M. Recognition of infected cells by natural killer cells. Curr Opin Immunol 2004; 16:26-33.

51. French, A.R., and Yokoyama, W.M. Natural killer cells and autoimmunity. Arthritis Res Ther 2004; 6:8-14. PMCID: PMC400423

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52. Yokoyama, W.M. Betting on NKT and NK cells. Immunity 2004; 20:363-365. 53. Liszewski, M.K., Yokoyama, W.M., and Atkinson, J.P. II: Innate Immunity. 6 Immunology/Allergy. In

ACP Medicine Online (Dale, D.C., and Federman, D.D., Eds.), New York: WebMD Inc., 2004. 54. Yokoyama, W.M. Natural killer cell immune responses. Immunol Res 2005; 32:317-326. 55. Yokoyama, W.M. Specific and non-specifc natural killer cell responses. Adv Exp Med Biol 2005; 560:57-61. 56. Plougastel, B.F.M, and Yokoyama, W.M. Extending missing-self? Functional interactions between lectin-

like Nkrp1 receptors on NK cells with lectin-like ligands. In Vivier, E. and Colonna, M. (Eds.), Immunobiology of Natural Killer Cell Receptors. Curr Topics Microbiol Immunol 2006; 298:77-89.

57. Liszewski, M.K., Yokoyama, W.M., and Atkinson, J.P. Chapter 102: Innate Immunity. In ACP Medicine (Dale, D.C., and Federman, D.D., Eds.), New York: WebMD Inc., 2006; pg 1197-1207.

58. Yokoyama, W.M., and Kim, S. How do natural killer cells find self to achieve tolerance? Immunity 2006; 24:249-257.

59. Yokoyama, W.M. Contact hypersensitivity: Not just T cells! Nature Immunol 2006; 7:437-439. 60. Yokoyama, W.M. and Kim, S. Licensing of natural killer cells by self-major histocompatibility complex class

I. Immuno Rev 2006; 214:143-154. 61. Yokoyama, W.M., and Kim, S. Analysis of individual natural killer cell responses. Methods in Molecular

Biology 2007; 415:179-196. 62. Yokoyama, W.M. and Riley, J.A. NK cells and their receptors. RBM Online 2008; 16:173-191. 63. Yokoyama, W.M. Chapter 17. Natural killer cells. In Paul, W.E. (Ed.) Fundamental Immunology (Sixth

Edition), Lippincott-Raven, New York. 2008; pg 483-517. 64. Yokoyama, W.M., and Colonna, M. Innate immunity to pathogens. Curr Opin Immunol 2008; 20:1-2.

PMCID: PMC2289433. 65. Riley, J.A. and Yokoyama, W.M. NK cell tolerance and the maternal-fetal interface. Am J Reprod Immun

2008; 59:371-387. 66. Yokoyama, W.M. Mistaken notions about natural killer cells. Nature Immunol 2008; 9:481-485. 67. Scalzo, A.A., and Yokoyama, W.M. Cmv1 and natural killer cell responses to murine cytomegalovirus

infection. Curr Top Immuno Microbio 2008; 321:101-122. 68. Yokoyama, W.M. Inhibitory receptors signal activation. Immunity 2008; 29:515-517. 69. Jonsson, A.H., and Yokoyama, W.M. Natural killer cell tolerance: Licensing and other mechanisms. Adv

Immunol 2009; 101:27-79. 70. Cooper, M.A., Colonna, M., and Yokoyama, W.M. Hidden talents of natural killers: NK cells in innate and

adaptive immunity. EMBO Reports 2009; 10:1103-1110. PMCID: PMC2759738 71. Jonsson, A.H., and Yokoyama, W.M. Assessing licensing of NK cells. In Campbell, K.S. (Ed.), Natural killer

cell protocols: Cellular and molecular methods, 2nd Edition. Meth Mol Biol 2010; 612:39-49. 72. Cooper, M.A., and Yokoyama, W.M. Memory-like responses of natural killer cells. Immunological Reviews

2010;235:297-305. PMCID: PMC2907109 73. Yokoyama, W.M., Altfeld, M., and Hsu, K.C. Natural killer cells: Tolerance for self and innate immunity to

viral infection and malignancy. Biol Blood Marrow Transplant 2010; 16:S97-S105. PMCID: NIHMS152698 74. Vivier, E., Raulet, D.H., Moretta, A., Caligiuri, M.A., Zitvogel, L., Lanier, L.L., Yokoyama, W.M., and

Ugolini, S. Innate or adaptive immunity? The example of natural killer cells. Science 2011; 331:44-49. PMCID: PMC3089969

75. Elliott, J.M., and Yokoyama, W.M. Unifying concepts of MHC-dependent NK cell education. Trends Imm 2011;32:363-372.

76. Kim, A.H.J., and Yokoyama, W.M. Chapter 12. Systemic lupus erythematosus. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 124-144.

77. Gupta, R., and Yokoyama, W.M. Chapter 13. Gout. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 145-153.

78. Archer, A., and Yokoyama, W.M. Chapter 14. Calcium pyrophosphate dihydrate crystal deposition disease. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 154-159.

79. Kuhn, K.A. and Yokoyama, W.M. Chapter 15. Undifferentiated spondyloarthritis. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 160-168.

80. Davila, L., and Yokoyama, W.M. Chapter 16. Ankylosing spondylitis. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 169-175.

81. Archer, A., and Yokoyama, W.M. Chapter 17. Psoriatic arthritis. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 176-182.

82. Joshi, R., and Yokoyama, W.M. Chapter 18. Reactive arthritis. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 183-187.

83. Kuhn, K.A., and Yokoyama, W.M. Chapter 19. Enteropathic arthritis. In Kahl, L.E. (Ed.) The Washington Manual Rheumatology Subspecialty Consult (Second Edition), Wolters Kluwer, Philadelphia, 2012, pg 188-192.

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84. McCoy IV, W.H., Wang, X., Yokoyama, W.M., Hansen, T.H., and Fremont, D.H. Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation. Molecular Immunology 2013; 55:156-158.

85. Yokoyama, W.M. Chapter 17. Natural killer cells. In Paul, W.E. (Ed.) Fundamental Immunology (Seventh Edition), Lippincott-Raven, New York. 2013; pg 395-430.

86. Fogel, L.A., Yokoyama, W.M., and French, A.R. Natural killer cells in human autoimmune disorders. Arth Res Ther 2013; 15:216-225.

c. Books 1. Paul, W.E., Littman, D.R. and Yokoyama, W.M. (Eds.) Annual Review of Immunology Vol. 27, Annual Reviews,

Inc. Palo Alto, 2009, 762 pp. 2. Paul, W.E., Littman, D.R. and Yokoyama, W.M. (Eds.) Annual Review of Immunology Vol. 28, Annual Reviews,

Inc. Palo Alto, 2010, 694 pp. 3. Paul, W.E., Littman, D.R. and Yokoyama, W.M. (Eds.) Annual Review of Immunology Vol. 29, Annual Reviews,

Inc. Palo Alto, 2011, 762 pp. 4. Paul, W.E., Littman, D.R. and Yokoyama, W.M. (Eds.) Annual Review of Immunology Vol. 30, Annual Reviews,

Inc. Palo Alto, 2012, 822 pp 5. Littman, D.R., and Yokoyama, W.M. (Eds.) Annual Review of Immunology Vol. 31, Annual Reviews, Inc. Palo

Alto, 2013, 791 pp

d. Patents U.S. Patent No. 6,548,737, “Transgenic Mice Deficient in Natural Killer Cells”, April 15, 2003. W.M. Yokoyama and S. Kim, inventors.

e. Licensed inventions (each to one or more companies)

1. Monoclonal antibody specific for mouse gp49. With L. Wang, 1998. 2. Two monoclonal antibodies specific for mouse NKG2D. With E. Ho, 2003. 3. Monoclonal antibody specific for RAE-1δ. With L. Carayannopoulos, 2004. 4. cDNA for RAE-1δ. With L. Carayannopoulos, 2004. 5. Cell lines transfected with RAE-1δ. With L. Carayannopoulos, 2004. 6. NK cell lines derived from p53-deficient mice, 2004. 7. Monoclonal antibody specific for Ly49H. With H. Smith, 2007.