CSIRO HEALTH SCIENCES

& NUTRITION

WELCOME

Presented by: Poh Len Pek Thursday, 20 May 2004

Life Sciences research in: Prevention Diagnosis of diseases Treatment

CSIRO Health Sciences and Nutrition

Improvement of human well-being & community health while enhancing the competitiveness of the Australian food, diagnostic and pharmaceutical industries.

180 Scientists & staff A$24m Research spend

Adelaide

Gastrointestinal Health Clinical Nutrition Human Clinical Studies Consumer Science

Diagnostic & Therapeutic Technologies Protein & Receptor Structure and

Function Structure-based Drug Design

Melbourne Disease Prevention Diagnosis & Treatment

Industries served: Food, Health, Diagnostic and Pharmaceutical

Disease Prevention Diagnosis Treatment

Commercial Engagement

Strategic Long Term Collaboration : Partnership • Leveraged Funding, Co-investment

• Shared risks + rewards

Fee For Service & Contract R&D

• Consulting & Projects

• Analytical Services

• Clinical Studies

• Market Rates

Licensing • Royalty on Sales

• Health effects • Nutrient intake

trends • Physiological and

biochemical mechanisms

• Consumer science • Psycho-social

determinates of acceptance

Opportunity Validation

in vitro in vivo

Validation Human Clinical study

Consumer Uptake

• Rapid method/ assays

• Biomarkers • Bioavailability

• Efficacy testing • Biomarkers • Scientifically

accepted & well designed intervention trials

• Partner in NCEFF

• Drivers of consumer behaviour

• Product acceptance

• Communication strategies

• Regulatory assessment

Health Sciences & Nutrition Capabilities

IDEA MARKET

Taking Health & Nutrition Products to Market

Leadership - Dr Katrine Baghurst

Professional team of 14 staff : • Research scientists • Psychologists • Technicians

Consumer Science Team

Dr. Baghurst is Chair of the National Health & Medical Research Council (NHMRC) - Dietary Guidelines Review Working Party

Risk Perceptions of Consumer to Preventative Health Strategies

Novel methods for assessing risk. Eg Cost benefit and effectiveness of faecal occult blood testing in colorectal cancer screening strategies

Consumer Acceptance of Functional and Novel Foods Cognitive & Sensory Drivers

Marketing Strategy Product Name, Positioning, Point of difference Likely target market, Price Point

Marketing Communication Strategies Target consumer markets, Community, Food Industry,

Health & Government

Consumer Science Capabilities & Research Focus

Mood and Cognition Impact of nutrients, nutrient mix and food components

Establishing and monitoring in Australia & Asia of: Food and nutrient intake trends Population health and nutritional status Consumer attitudes & cross-cultural

differences Determinants of consumer food choice

eg, Age & sensory factors affecting choice of meat products that assisted in new meat product development

Food availability, legislation and policy Opportunity identification for government or industry

Consumer Science Capabilities & Research Focus

Medical Director Leadership - Dr Peter Clifton

Over 2 decades in clinical substantiation studies

Trials from 10 to 120 (volunteer) subjects per trial

Clinical Research Unit Team

Professional team of 15 staff : Research scientists Dietitians Nurses Clinical Trial Managers

(GCP certified) Technical & Analytical staff

Excellence in Management of Human Intervention Trials

Clinical Research Unit - Substantiation

Substantiation of health benefits, claims and potential of :

Functional Foods Diets Food products /Ingredients Novel Foods Nutrients Supplements Complementary medicine Drugs (Phase II & III

– drug efficacy and dosage)

►Knowledge of relevant and emerging biomarkers

►Trial management to Good Clinical Practice

►Data management, analysis, interpretation & publication

Clinical Research Unit Capabilities

►Indications for human interventions

►Ethics

►Cost effective trial design

►Communication strategies to scientific, media, general public and food industry

►State-of-art instrumentations eg. comprehensive cardio range

Impact of various dietary composition on:

Heart disease Hypertension Metabolic Syndrome Obesity Diabetes Glycemic Response Satiety Bowel Health

Clinical Research Unit - Dietary Research Capabilities

Leadership - Dr David Topping

Professional team of 30 Research Scientists, Technical and Analytical staff

Gastrointestinal Health Team

Capabilities

Dietary carbohydrates, fats and other food components on bowel health.

In vitro, animal and human ileostomy studies on gut health and function.

Gut microflora composition and activity by measuring SCFAs & other metabolites.

Modelling carbohydrate (eg prebiotic and resistant starch) effect on gut physiology and function using novel and conventional bowel health biomarkers.

Enhancement of mineral (Ca, Fe, Zn, Mg) absorption and bioavailability in large intestine.

Molecular microbiology and biomarkers.

Prebiotic, probiotic and synbiotic New bowel health products

Gastrointestinal Health Research Focus & Capabilities

Gastrointestinal Health Research Focus & Capabilities

Plant derived water soluble antioxidants/bioactives for vascular function

Screening assays for bioactive molecules Bioavailability of nutrients & phytochemicals Novel antimicrobial agents from biowaste

Your contact

Poh Len Pek Business Development Manager pohlen.pek@csiro.au Tel: 08 8303 8893 (Adelaide) 03 9662 7117 (Parkville) Mobile: 0417 007 118

For more information, see www.hsn.csiro.au or contact: