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1. MOLECULES & THEIR INTERACTION

RELAVENT TO BIOLOGY 

A. Structure of atoms, molecules and chemical bonds.

B. Composition, structure & function of biomolecules

(carbohydrates, lipids, proteins, N.Acids and vitamins).

C. Stabilizing interactions (Van der Waals, electrostatic,

hydrogen bonding, hydrophobic interaction, etc.).

D. Principles of biophysical chemistry (pH, buffer,

reaction kinetics, thermodynamics, colligative 

 properties).

E. Bioenergetics, glycolysis, oxidative phosphorylation,

coupled reaction, group transfer, biological energy

transducers.

F. Principles of catalysis, enzymes and enzyme kinetics,

enzyme regulation, mechanism of enzyme catalysis,

isozymes.

G. Conformation of proteins (Ramachandran plot, 20, 30

& 40 structures; domains; motif and folds).

H. Conformation of nucleic acids (A-, B-, Z-, DNA), t-

RNA, micro-RNA).

I. Stability of protein and nucleic acid structures.

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J. Metabolism of carbohydrates, lipids, amino acids,

nucleotides and vitamins.

2. CELLULAR ORGANIZATION 

A. Membrane structure and function: Structure of 

model membrane, lipid bilayer and membrane protein

diffusion, osmosis, ion channels, active transport, ion

 pumps, mechanism of sorting & regulation of intracellular 

transport, electrical properties of membranes.

B. Structural organization and function of 

intracellular organelles: Cell wall, nucleus,

mitochondria, Golgi bodies, lysosomes, ER ,

 peroxisomes, plastids, vacuoles, chloroplast, structure &

function of cytoskeleton and its role in motility.

C. Organization of genes and chromosomes: Operon,

interrupted genes, gene families, structure of chromatin

and chromosomes, unique and repetitive DNA,

heterochromatin, euchromatin, transposons.

D. Cell division & cell cycle: Mitosis and meiosis, their 

regulation, steps in cell cycle, and control of cell cycle.

E. Microbial Physiology: Growth, yield &characteristics, strategies of cell division, stress response.

3. FUNDAMENTAL PROCESSES 

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A. DNA replication, repair and recombination: Unit of 

replication, enzymes involved, replication origin andreplication fork, fidelity of replication, extrachromosomal

replicons, and DNA damage and repair mechanisms.

B. RNA synthesis and processing: Transcription factors

and machinery, formation of initiation complex,

transcription activators and repressors, RNA polymerases,

capping, elongation & termination, RNA processing,RNA editing, splicing, polyadenylation, structure and

function of different types of RNA, RNA transport.

C. Protein synthesis and processing: Ribosome,

formation of initiation complex, initiation factors and

their regulation, elongation and elongation factors,

termination, genetic code, aminoacylation of tRNA,tRNA-identity, aminoacyl tRNA synthetase, translational

 proof-reading, translational inhibitors, post- translational

modification of proteins.

D. Control of gene expression at transcription and

translation level: Regulation of phages, viruses,

 prokaryotic and eukaryotic gene expression, role of 

chromatin in regulating gene expression and gene

silencing.

4. CELL COMMUNICATION & CELL SIGNALING 

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A. Host parasite interaction: Recognition and entry

 processes of different pathogens like bacteria, viruses intoanimal and plant host cells, alteration of host cell behavior 

 by pathogens, virus-induced cell transformation,

 pathogen-induced diseases in animals and plants, cell-cell

fusion in both normal and abnormal cells.

B. Cell signaling: Hormones and their receptors, cell

surface receptor, signaling through G-protein coupledreceptors, signal transduction pathways, second

messengers, regulation of signaling pathways, bacterial

and plant two-component signaling systems, bacterial

chemotaxis and quorum sensing.

C. Cellular communication: Regulation of hema

topoiesis, general principles of cell communication, celladhesion and roles of different adhesion molecules, gap

 junctions, extracellular matrix, integrins,

neurotransmission and its regulation.

D. Cancer: Genetic rearrangements in progenitor cells,

oncogenes, tumor suppressor genes, cancer and the cell

cycle, virus-induced cancer, metastasis, interaction of 

cancer cells with normal cells, apoptosis, therapeutic

interventions of uncontrolled cell growth.

E. Innate and adaptive immune system: Cells &

molecules involved in innate and adaptive immunity,

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antigens, antigenicity and immunogenicity. B and T cell

epitopes, structure & function of antibody molecules,

generation of antibody diversity, monoclonal antibodies,

antibody engineering, antigen-antibody interactions,MHC molecules, antigen processing & presentation,

activation and differentiation of B & T cells, B and T cell

receptors, humoral & cell-mediated immune responses,

 primary & secondary immune modulation, the

complement system, Toll-like receptors, cell-mediated

effector functions, inflammation, hypersensitivity &

autoimmunity, immune response during bacterial

(tuberculosis), parasitic (malaria) & viral (HIV)

infections, congenital and acquired immunodeficiencies,

vaccines.

5. DEVELOPMENTAL BIOLOGY 

A. Basic concepts of development: Potency,

commitment, specification, induction, competence,

determination & differentiation; morphogenetic gradients;

cell fate & cell lineages; stem cells; genomic equivalence

and the cytoplasmic determinants; imprinting; mutants &

transgenics in analysis of development.

B. Gametogenesis, fertilization and early development: Production of gametes, cell surface molecules in sperm-egg recognition in animals; embryo sac development &

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double fertilization in plants; zygote formation, cleavage,

 blastula formation, embryonic fields, gastrulation &

formation of germ layers in animals; embryogenesis,

establishment of symmetry in plants; seed formation &germination.

C. Morphogenesis & organogenesis in animals: Cell

aggregation & differentiation in Dictyostelium; axes and

 pattern formation in Drosophila, amphibia and chick;

organogenesis - vulva formation in Caenorhabditis

elegans; eye lens induction, limb development &regeneration in vertebrates; differentiation of neurons,

 post embryonic development-larval formation,

metamorphosis; environmental regulation of normal

development; sex determination.

D. Morphogenesis and organogenesis in plants: 

Organization of shoot and root apical meristem; shoot androot development; leaf development and phyllotaxy;transition to flowering, floral meristems and floral

development in Arabidopsis and Antirrhinum.

E. Programmed cell death, aging and senescence. 

6. SYSTEM PHYSIOLOGY - PLANT 

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A. Photosynthesis: LH complexes; mechanisms of ETC;

 photoprotective mechanisms; fixation- , CAM

 pathways.

B. Respiration & photorespiration: TCA cycle; plant

mitochondrial ET & ATP synthesis; alternate oxidase;

 photorespiration.

C. Nitrogen metabolism: Nitrate and ammonium

assimilation; amino acid biosynthesis.

D. Plant hormones: Biosynthesis, storage, breakdownand transport; physiological effects and mechanisms of 

action.

E. Sensory photobiology: Structure, function &

mechanisms of action of phytochromes, cryptochromes &

 phototropins; stomatal movement; photoperiodism and

 biological clocks.

F. Solute transport & photoassimilate translocation: Uptake, transport & translocation of water, ions, solutes

& macromolecules from soil, through cells, across

membranes, through xylem & phloem; transpiration;

mechanisms of loading & unloading of photoassimilates.

G. Secondary metabolites: Biosynthesis of terpenes,

 phenols and nitrogenous compounds and their roles.

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H. Stress physiology: Responses of plants to biotic

(pathogen and insects) and abiotic (water, temperature

and salt) stresses; mechanisms of resistance to biotic

stress and tolerance to abiotic stress

7. SYSTEM PHYSIOLOGY - ANIMAL 

A. Blood and circulation: Blood corpuscles,

haemopoiesis and formed elements, plasma function,

 blood volume, blood volume regulation, blood groups,haemoglobin, immunity, haemostasis.

B. Cardiovascular System: Comparative anatomy of 

heart structure, myogenic heart, specialized tissue, ECG -

its principle and significance, cardiac cycle, heart as a

 pump, blood pressure, neural and chemical regulation of 

all above.

C. Respiratory system: Comparison of respiration in

different species, anatomical considerations, transport of 

gases, exchange of gases, waste elimination, neural and

chemical regulation of respiration.

D. Nervous system: Neurons, action potential, grossneuroanatomy of the brain and spinal cord, central and

 peripheral nervous system, neural control of muscle tone

and posture.

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E. Sense organs: Vision, hearing and tactile response.

F. Excretory system: Comparative physiology of 

excretion, kidney, urine formation, urine concentration,waste elimination, micturition, regulation of water 

 balance, blood volume, blood pressure, electrolyte

 balance, acid-base balance.

G. Thermoregulation: Comfort zone, body temperature -

 physical, chemical, neural regulation, acclimatization.

H. Stress and adaptation 

I. Digestive system: Digestion, absorption, energy balance, BMR.

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CSIR life science syllabus

The Joint CSIR-UGC JRF/LS (NET) Examination

shall comprise 2 papers: PAPER I: duration: 2 1/2

hours and maximum of 200 marks. 2 marks each

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csirumadevi  – 10 days ago

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respected sir/madam,

sir,can you pls give me the information about ugc csir 

net 2013 exam.

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Link ajaispice  – 18 days ago

refer me some book relate with life science for csir 

 prepartaion… sir…. 

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PrakashMuthuswamy  – about 1 month ago

sir, i want details of reference book for life science.

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Link science_shibu  – 2 months ago

respected mam, sir 

 plz send me csir syllabus for biochemistry &

 biotechnology

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aaqi  – 2 months ago

sir…….plz recommend me some books to prepare

for csir net……. 

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shreyoshighosh23  – 2 months ago

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Please suggest me some reference book for the test

especially for the chemistry parts and the evolution

chapters.

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Link ekchikhlonde  – 3 months ago

 please send me the name and auther name of book ,

which i will refer for NET preperation

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hone  – 3 months ago

sir i have passed msc medical anatiomy pls sendsyllabus for csir net exam thank u

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Link sath-green  – 3 months ago

Sir,i have completed my m.sc.microbiology,n want to

do CSIR- NET life science …plz suggest me booksfor 

reference

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tomJery  – 3 months ago

suggest me reference book for life science as i am

 preparing for net exam…. 

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would  – 4 months ago

sir please send us the reference books for life scienceReply to This

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vanasrilakshmi  – 4 months ago

sir,please send referance books for life since

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manojibss  – 4 months ago

sir ,please send me refrence book for life science.Reply to This

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arivu-mani  – 4 months ago

sir one request please i want to csir life science

reference book any suggestion please give to any

 book reference for my email id im waiting for your 

reply answer. thank you sir.

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dadaraolokhande  – 4 months ago

 pls. give me info. regarding reference books should i

refer for each unit for life science plz send us the

reference books for Life science

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Tirthankar Chkraborty  – 4 months ago

 pls. provide with some handbook as reference books

for life science for my preparation for CSIR NET,December 2012.

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palanisamykrishnan  – 4 months ago

sir am studing m.sc-biochemistry ,so i am eliglb for 

this csir net exam.

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pradeep k p  – 4 months ago

i need the reference books for net exam

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Link wild_hurb_life  – 4 months ago

i am doinng m.tech in nanotechnology, and b.tech in

 biotechnology,pls give me i opt in enggineering

science or life science ,and send me some refernce book and model paper 

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candana  – 5 months ago

hi:-) am doing m.pharma(pharmaceutics)..

what is the eligibility creteria for csir exam?

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Link pgreenniharika  – 5 months ago

sir i want notes regarding csir net life sciences exam

… if u can then please send me the solved sample

 papers to my id

 pant_nisha@ymail.com

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nponnen  – 5 months ago

i am preparing to write life science exam in Dec

2012. Which book is suitable to me

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Geetha shalini  – 6 months ago

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Sir,i want reference book for life science

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nathiyaprabu  – 6 months ago

sir, i want reference books for life science.please

send me my mail id.

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om_sairamd  – 6 months ago

 please give me appropriate syllabus for csir life

science.

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prashant takdhat  – 6 months ago

 pls. give me list of reference books for preparing csir 

net in life sciences

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Link SUNAINISURESH  – 6 months ago

Respected Sir/Madam,

Can you please give me some informations regarding

csir-net exam and the complete syllabus which is

going to be held on december-2012 and reference

 books. This wil be very much useful for my

 preparation. THANK YOU.

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anitha--  – 6 months ago

respected sir/madam,want the complete life science syllabus for the CSIR 

whichs comming on DECEMBER2012……please do

reply to my id.thank u :)

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Link preetam nikam  – 7 months ago

sir, i want details of reference book for life science.

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Link  jurrasic park   – 7 months ago

i want full syllabus for csir life science syllabus

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