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Avantium 2009 & Confidential

C r y s t a l l i z a t i o n S y s t e m s

T u n i n g t u r b i d i t y

Tuning turbidity

Avantium Crystallization Systems 2

Content

EXPLANATION OF THE TUNE STEP .................................................3

1. EXAMPLE CRYSTAL16® ...............................................................4

2. EXAMPLE CRYSTALLINE® ...........................................................5

Tuning turbidity

Avantium Crystallization Systems 3

Explanation of the tune step

The turbidity sensor of the Crystal16® and the Crystalline® can be tuned

to make the detection of the phase transition more sensitive and accurate.

The tune step can be programmed by the user and automatically adjusts

the light source intensity of each turbidity sensor to match the light range.

Two examples are shown in Figure 1.

Each new experiment in the Crystal16® and Crystalline® can best be tuned

at the start of the experiment with a clear “blank” and/or at the point

where all solids are in solution. At the beginning of the experiment, the

turbidity sensor can best be tuned with a reactor containing only the

solvent of the solutions.

Note: In case the compound colors the solution dark, the maximum light

transmission at a clear solution will be below 100%.

Figure 1: Explanation of tuning step with

a) Clear solution, b) Colored solution.

Tuning turbidity

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1. Example Crystal16®

An example program for the Crystal16® is given in Figure 2. Take care to

remove the blank and place the sample inside the reactor holder after the

stirrer is switched on. If you are not interested in the dissolution point in

the first heating cycle, remove the first tuning step from the program and

tune after complete dissolution.

Figure 2: Example program Crystal16®.

Tuning turbidity

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2. Example Crystalline®

An example program for the Crystalline® is given in Figure 3. Take care to

remove the blank and place the sample inside the reactor holder after the

second prompt in the program. If you are not interested in the dissolution

point in the first heating cycle, remove the first tuning step from the

program and tune after complete dissolution.

Figure 3: Example program Crystalline

Tuning turbidity

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