Critique of the angiosome concept It is not simple: outcomes … · 2016-08-11 · The angiosome...
Transcript of Critique of the angiosome concept It is not simple: outcomes … · 2016-08-11 · The angiosome...
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Critique of the angiosome concept
It is not simple: outcomes depend more on the distribution
system in the foot than angiosome
Roberto Ferraresi
Peripheral Interventional Unit
Bergamo – Italy
www.robertoferraresi.it
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Disclosure
I have the following potential conflicts of interest to report:
consulting, travel reimbursement, teaching courses,
training, proctoring:
• Medtronic
• Boston Scientific
• Abbott
• LimFlow
• Terumo
• Cook
• Biotronik
Roberto Ferraresi, MD
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The angiosome concept in real practice
2.
3.
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The angiosome concept in real practice
When feasible, direct
revascularization according to
the angiosome concept seems to
be better than indirect
revascularization in terms of
wound healing and limb salvage
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4 critics
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All of the studies
comparing direct and
indirect revascularization
are retrospective
1. We can assume that the operators focused on traditional optimal technical targets rather than the WRA
2. We don’t know if the same patients would have been technically revascularizable following an angiosome-oriented approach.
3. It is possible that in the “indirect revascularization” groups there was a propensity to collect patients with the most technically challenging disease and the differences in the outcomes may simply reveal basal differences in the extension and type of obstructive disease
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Try to do what is possible and don’t
lose time on unrealistic targets!
www.robertoferraresi.it
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Direct revascularization could have a different
value depending on the presence or not of a good
distal distribution network
Inadequate distal distribution systemGood distal distribution system
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Varela et al. demonstrated that
the restoration of blood flow to
the ulcer through collateral
vessels (pedal and distal
peroneal branches) provided
similar results to those obtained
through its specific source
artery in terms of healing and
limb salvage.
Good distal distribution system
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Kawarada et Al demonstrated that a
single tibial artery revascularization,
whether of the ATA or PTA, yielded
comparable improvements in
microcirculation of the dorsal and
plantar foot.
Good distal distribution system
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In diabetic and ESRD pts
collateral vessels formation is
reduced or absent foot
circulation becomes functionally
terminal because of lack of
collaterals. This is the reason
why we need to improve the
most direct blood flow to the
wounded area
Circulation, 1999;99:2239-2242;
Cardiovasc Res. 2001 Feb 16;49(3):554-60;
Circulation, 2004;2343-2348;
Azuma N et Al. Factors influencing wound healing of
critical ischaemic foot after bypass surgery: Is the
angiosome important in selecting bypass target artery? Eur
J Vasc Endovasc Surg 2012;43:322-28
Inadequate distal distribution system
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Azuma et Al. demonstrated that in
bypass surgery the angiosome
concept seems unimportant, at
least in non-ESRD cases.
"We believe that a good artery with
good runoff to the foot, regardless
of the angiosome, should be
selected in non-ESRD pts… On
the other hand, angiosome-
oriented target selection might
improve the poorer outcomes in
ESRD pts"
Inadequate distal distribution system
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The value of an angiosome-oriented
revascularization is inversely
related to the function of collateral
vessels
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Not every wound, especially in case of deep infection, is confined
into a single angiosome space; patients with extensive tissue
damage cannot be classified on the basis of an angiosome-
oriented revascularization.
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Open BTK vessels
Limbsalvage
0 56%1 better than 0
1 73%
2 80%2-3 better than 1
3 83%
PTA of tibial arteries had a better outcome than PTA of the peroneal artery alone
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Extensive tissue damage cannot be
classified on the basis of an
angiosome-oriented scheme. In
these patients complete rev. better
than partial rev
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Forefoot amputations (rays, trans-metatarsal, Lisfranc, Chopart)
are a common cause of foot circle interruption. In these cases we
must pursue the “surgical WRA” revascularization
“Willis like” foot circle
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Male, 64 yyType 2 DMNeuropathy, bones deformityChronic plantar ulcerForefoot infection with deep phlegmon
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TMT amputation
www.robertoferraresi.it
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Diagnosis
• Good FEM-POP patency• Good ATA with present dorsalis
pedis pulse• Occlusion of PTA with good
collateralization by peroneal posterior perforating branch
This patient has a pure neuropathic history; the arteriopathy was mild and was not responsible of the plantar lesion and of the catastrophic evolution in forefoot amputation.
Why has the plantar edge of the amputation an ischemic suffering?
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Diagnosis
• PTA occlusion• Plantar arteries occlusion• Dorsalis pedis tied by the
surgeon• The residual connection
between dorsal and plantar region are 2 thin tarsal arteries
In this patient there is an ischemic suffering of the plantar edge of the amputation without healing
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Forefoot amputations can interrupt
the foot circle. In these cases we
must pursue the “surgical WRA”
revascularization
Consider the rule of collateral
vessel disease/function
Try to do what is possible and don’t
lose time on unrealistic targets!
Complete rev. better than partial rev.
in Rutherford 6 pts