Critical Appraisal 8
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Transcript of Critical Appraisal 8
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Critical Appraisal
Rachel A Whitmer, Erica P Gunderson, Elizabeth Barrett-Connor, Charles P Quesenberry Jr, Kristine Yaffe
Obesity in middle age and future risk
of dementia: a 27 year longitudinalpopulation based study
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Introduction
validity
Reliability
Applicability
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Faktor ekstrinsik
- Siapa yang menulis
- Di mana ia/mereka bekerja
- Apa kualifikasinya
- Apakah anda pernah mendengar namanya
- Siapa yang menyeponsori
- Dimana tulisan tsb di muat
- Apakah ia/mereka pernah membuat tulisandalam bidang yang sama
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Siapa yg menulis, dimana mereka bekerja dan kualifikasi Division of Research, Kaiser Permanente, Oakland, CA 94612,
USA Rachel A Whitmer gerontological epidemiologist
Erica P Gunderson obesity epidemiologist
Charles P QuesenberryJr senior biostatistician
Department of Epidemiology, University of California, La Jolla,CA, USA
Elizabeth Barrett-Connor professor
Department of Psychiatry, University of California, San Francisco,
CA, USA Kristine Yaffe associate professor
Correspondence to: R A Whitmer [email protected]
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Faktor intrinsik
- Desain (penelitian) yang sesuai dengan
tujuan/pertanyaan penelitian
- Sampel yang sesuai
- Metode pengambilan sampel
- Metode untuk mendapatkan hasil
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Objective
To evaluate any association between obesity
in middle age, measured by body mass index
and skinfold thickness, and risk of dementia
later in life
Design
Analysis of prospective data from a
multiethnic population based cohort
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Participants
10 276 men and women who underwent detailed healthevaluations from 1964 to 1973 when they were aged 40-45and who were still members of the health plan in 1994
Main outcome measures
Diagnosis of dementia from January 1994 to April 2003.Time to diagnosis was analysed with Cox proportionalhazard models adjusted for age, sex, race, education,
smoking, alcohol use, marital status, diabetes,hypertension, hyperlipidaemia, stroke, and ischaemic heartdisease
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Conclusion
Obesity in middle age increases the risk of
future dementia independently of comorbid
conditions
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scorenoyesSection A
Population Appropriateness
1Is the study population representative of all
user, actual & eligible
1Are inclusion & exclusion criteria well
defined
1Sample size sufficient the estimation
1Response rate large enough for sufficiently
precise estimates
1The choice of population bias free
1
1
1
0
For Comparative study:
- Were participants randomized
into group
- Were the group comparable at baseline
-If group were not comparable atbaseline, was incompatibility addresed
at analysis
Informed consent is obtained
717
Section Validity = 7/8 x 100% = 87.5%
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Section B data collection Yes No Score
Data collection methods is clearly described Y 1
The data instrument is validated Y 1
The statistics are free from subjectivity (if based on regularly collected
statistic)
Y 1
The study measures outcome at a time appropriate for capturing theinterventions effect
Y
1
The instrument is included in publication Y 1
The questions are posed clearly enough to elicit precise answer Y 1
Those are involved in data collection, are not involved in delivering a
service to the target population
N 0
Section Validity = 6/7 x 100% = 85,714%
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scorenoyesSection C
Study Design
1Study design type is utilized appropriately
1Face validity
1Research methodology is clearly stated in detail
0Ethic approval
1Outcome is clearly stated
1The outcomes are clearly discussed in relation to data collection
515Section Validity = 5/6 x 100% =100 %
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Section D
Research Results
Yes No Score
The results are clearly outlinedY 1
Account for confounding variablesN 0
The conclusions accurately reflect the analysisY 1
Suggestions for further areas of research are addresedY 1
Section Validity = 3/4 x 100% = 75 %
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R
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Applicability
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