Creating sustainable resources through interdisciplinary ... · Kazuo Shinozaki Kazuki Saito...
Transcript of Creating sustainable resources through interdisciplinary ... · Kazuo Shinozaki Kazuki Saito...
Creatingsustainableresourcesthrough
interdisciplinaryresearchbasedonbiologyandchemistry
RIKENCenterforSustainableResourceScience(CSRS)Since2013
CenterDirectorKazuoShinozaki
1
RIKENEuropeOfficeAnniversarySymposiumShapingfuturesocietywithcutting-edgeSTI
December2,2019
Ocean and soil pollution,desertification
Global Warming,Climate change
- Contribution to SDGs - Breeding of crops and biomass- Sustainable production of materials- Carbon capture and utilization
Importance of science and technology for sustainable
development of society.
Increasing Global Populations
2
Science and technology contribute to solve global problems.
2ReportofIPCCOctober6,2018
Desertification
TheSustainableDevelopmentGoals(SDGs),UN2015.9
COP21TheParisAgreement2015.11
GenomeTechnologies- Genomesequencetechnology- Genomeeditingtechnology- SyntheticGenomics
DataScienceandArtificialIntelligence- DataScience- ArtificialIntelligence- Bioinformatics,MaterialInformatics,
ParadigmShiftinSocialNeedsandTechnologies
Society5.0fortheadvancementofsmartsociety (5thScienceandTechnologyBasicPlan,JapanCabinetOffice,2016-2020)-RIKENstartedAIPcenter(AIanddatascience)in2015
3
IntroductionofRIKENCSRSProjects
DirectorKazuoShinozaki
KazukiSaito
●Startedin2013bythereorganizationofPlantScienceCenter,ChemicalBiology,andCatalyticChemistryProgramsforthecontributiontoasustainableproductionbasedonbiologyandchemistry.BiomassEngineeringProgramjoinedCSRSin2015.●Started5flagshipprojectsin2018forthecontributiontoSustainableDevelopmentGoals(SDGs) andSociety5.0.
DeputyDirectors
HiroyukiOsada ZaominHou MinamiMatsui
CreationandEfficientusageofnaturalresourcesforsustainabledevelopmentofhumankind �
4
• 5 flagship projects contributing to “Sustainable Development Goals (SDGs)” are promoted to incorporate plant biology, biotechnology, chemical biology, and chemistry.
• Based on results of first phase, R&D on problem-solving is based on sustainable production of useful materials and biomass.
• Establish various types of collaboration
Contributing to sustainable food and biomass production through development of plant trait improvement techniques
Maximizing capacities of plants and microorganisms for chemical synthesis in expanding the production and use of bioproducts
Developing new, highly efficient catalysts that use natural resources
Developing new polymers with beneficial functions improving efficiency in the use of resources and creating new industries
Advancing analytical technology and information platforms and leading innovation as a science and technology hub in Japan
5
5FlagshipProjectsin4thMidtermPlan
5FlagshipProjectsin4thMidtermPlan
CSRSorganization3Locations:Yokohamacampus,Wakocampus,TsukubacampusMembers:31PIs,150researchers+postdocs,100technicalstaffsCenterBudgets:1,820millionyen(15,6millionEUR)
Contributing to sustainable food and biomass production through development of plant trait improvement techniques 10 Labs
Maximizing capacities of plants and microorganisms for chemical synthesis in expanding the production and use of bioproducts 5 Labs
Developing new, highly efficient catalysts that use natural resources 5 Labs
Developing new polymers with beneficial functions improving efficiency in the use of resources and creating new industries 3 Labs
Advancing analytical technology and information platforms and leading innovation as a science and technology hub in Japan 12 Labs
6
TechnologyPlatformDivisionMolecularStructureCharacterizationUnit BiomolecularCharacterizationUnit
MassSpectrometryandMicroscopyUnit
• MassSpectrography(MS)andNMRplatformforanalyzingplantmetabolomesandhormones
MassspectroscopeandNMRdeviceforanalyzingmetabolomes/hormones
Microscopesforanalysisoftissuesandcells
ChemicalBiologyResearchGroup
PlatformforChemicallibrariesandchemicalscreening
Explorationofchemicalsusingchemicalarrays
MetabolomicsResearchGroup
Databaseformetabolites(NPPlot)
KazukiSaitoDeputyDirector
HiroyukiOsadaDeputyDirector
Natural compound library (NPDepo)
AdvancedResearchandTechnologyPlatforms
7
PromotesnewmethodsandtechnologicaldevelopmentrelatedtoNMRandMSnecessaryfordeterminationofstructure
Promotesappliedresearchondevelopingmethodstoanalyzethestructureofbiologicalcomponentsandstructuralanalysis
Isoprene bio-production by designing an artificial metabolic pathwayKondogroupsucceededinconstructinganartificialmetabolicpathwaysynthesizingisopreneefficientlyinE.coli,andcollaboratedwitharubbercompanyforapplication.
ResearchAchievements 1
8
Plant-derived biodegraded polymer AbegrouphascollaboratedwithKanekacompanytodevelopbiodegradedpolymerPHAandPHB.Recently,thePHBbiopolymerisrecognizedasusefulbiodegradedplasticsthatcansolvemicro-plasticpollutioninocean.
New type of self-healing material Hougroupsucceededincreatingnewfunctionalpolymerswithcharacteristicsofself-healingandshapememoryundertheconditionsinnotonlydryairbutalsowater,andacidicandalkalineaqueoussolutions.Thisresearchwasveryuniqueandvisibletoattractmanycompanies.(JACS2019)
SaitogroupsucceededtoreduceSGAcontentbysuppressinggenesthatareexpressedinshootsandflowers.Theyieldofpotatodoesnotchange,andstoringwithoutsprouting.(PlantCell2014,PlantPhys.2016)
Developmentofpoisonlesspotatoes,thatcanbestoredforalongtime
NewlydiscoveredpeptidehormonehelpskeepplantsfromdehydrationShinozakigroupdiscoveredCLE25peptideregulatingdehydrationstressresistanceviaroot-to-shootlongdistancesignaling.Thisdiscoverywasuniqueandvisibleinplantscience. (Nature2018) Drought CLE25
CLE25
ABA
Stomata Close
Stress genes
ResearchAchievements 2BreedingdroughttolerantuplandriceGMcultivarsandtheirfieldtestTheGolS2transgenicriceplantsaredroughttolerantandmaintainahighcropyieldunderdryfieldofCIATinColumbia (PlantBiotechJ2017)
Non-transgenicrice IntroducedAtGolS2rice
9
Lam-SonPhanTran
2018JapanMedicalResearchandDevelopmentGrandPrize
ChemicalBiologyFunctionalgenomics
M.Yoshida
PlantScienceandBiochemistryarevisibleresearchareainRIKEN
Source:ScienceMap2014,NISTEPREPORTNo.169,September,2016.MEXTNISTEPcreatedandprocessedbyRIKEN.
PlantscienceBiomass
Catalystchemistry
Chemicalbiology
9researchersfromCSRS(6PIs,and3others)selectedas“HighlyCitedResearchers2018*”byClarivateAnalytics(formerlyThomsonReuters)(*Authorswhosepublicationswerequotedinthetop1%from2006to2016)
KazuoShinozaki KazukiSaito
MotoakiSeki MitsunoriSeo
KenShirasu
※ClarivateAnalyticsselected90researchersfromJapan,of20researcherswereselectedin4fieldsfromRIKEN.
2016PersonofCulturalMerit/MedalwithPurpleRibbon
K.Shinozaki
Plantstressbiology,Functionalgenomics
2018MedalwithPurpleRibbon
K.Saito
PlantMetabolomicsMetabolicengineering
2015InhoffenMedalFirstJapanesetoreceivetheaward
H.Osada
ChemicalBiology,Drugdiscovery
High-levelresearch:Plantscienceandchemicalbiology
10
Project Management in CSRS
CSRSCoreresearch
Platform
RIKENProjects
CSRSProjects
University,Inter-MinistryCollaboration
International,Industrial
Collaboration
Varioustypesofcollaborationareimportantforthesegoals �
Microbial–hostsymbioticSystem,iSYM(2017-)DrugDiscoveryPlatform(2010– )
AIST,NARO,FFPRI,FRA
NagoyaUniv.YokohamaCityUniv.KeioUniv.
MaxPlanckInst.(Germany)VIB-PSB(Gent,Belgium)JohnInnesInstitute(UK) INRA(Paris,France)MichiganStateU.(US)UniversityofToronto(Canada)
11
InternationalcollaborationsinCSRS
①
④
⑩
⑤
A
B
C
H
E F
G
InternationalCollaborationisimportantforinnovation.
D
J
I
12
(Joint papers/1311 papers, 2015-2018)
K
◉ Max Planck Institute of Molecular Plant Physiology, Germany (32) ◉ Max Planck Institute of Systems Chemical Biology, Germany
◉ The Sainsbury Laboratory, UK (11)
◉ Umea Plant Science Center, Sweden
◉ Michigan State University, USA
◉ University of Toronto, Canada (12)
◉ Universiti Sains Malaysia, Malaysia ◉ Agricultural Genetics Institute, Viet Nam
◉ International Center for Tropical Agriculture, Columbia
◉ INRA, France
F
F
◉ VIB-Plant Systems Biology, Belgium
CollaborationswithinstitutesinEUcountries
13
- Chemical Biology ◉ Max Planck Institute of Systems Chemical Biology, Germany - Plant Metabolomics ◉ Max Planck Institute of Molecular Plant Physiology, Germany ◉ Umea Plant Science Center, Sweden - Plant Biology ◉ John Innes Centre and the Sainsbury Laboratory, UK - Plant hormone Research ◉ INRA, France - Plant Biology ◉ VIB-Plant Systems Biology, Gent, Belgium
-WehavebeencollaboratingwithInstitutesinEUcountriesmainlyinplantbiologyandchemicalbiology.-WeareplanningtopromotecollaborationwithVIB,Belgium.
14
Thank you for your attention.
We are planning to promote various types of collaboration with Institutes in EU countries for the contribution to SDGs.
http://www.csrs.riken.jp/ https://www.riken.jp/en/en/
RIKEN CSRS