Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â...
11
Transcript of Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â...
![Page 1: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/1.jpg)
![Page 2: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/2.jpg)
![Page 3: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/3.jpg)
![Page 4: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/4.jpg)
![Page 5: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/5.jpg)
![Page 6: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/6.jpg)
![Page 7: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/7.jpg)
![Page 8: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/8.jpg)
![Page 9: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/9.jpg)
![Page 10: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/10.jpg)
![Page 11: Craik Lab · UCSF · general-base catalyst and proton donor to the leaving group. Tyr37 va138 3.0Â 3.0È Gly39 Tyr248 which indicates that the phenolic hydroxyl of Tyr248 forms hydrogen](https://reader033.fdocuments.us/reader033/viewer/2022042405/5f1e6880c54b341db351cfd6/html5/thumbnails/11.jpg)