Course:Biology Out of Balance

Module 1:Pathophysiology of the Liver and Detoxification1.5 CEU-NCCAOM

Instructor:Debi Rene Weiss, LAc., RN

Debi Weiss, R.N., Lic. Ac., Director of Transition to Health, Minneapolis, MN

Originator of the Ideal Weight Program

Weissacupuncture@gmail.com

dstarwynn@edastwestmed.com

� Liver Physiology

� Liver-Gut Axis: Biotransformation

� Liver-Gut Axis: Immunological Response

� Toxicity

� Sources

� Symptomology

� Liver Pathophysiology

� Phase I & II pathways

� Detoxification Protocols

� Nutritional

� Herbal/neutraceuticals

� Clay

� Rebounding

� Acupuncture

� Microcurrent/Color

Simple Questions, ch. 8:

“The Liver is like an army’s general from whom the strategy is derived.”

� Directs Qi

� Stores Blood

� Controls Sinews

� Manifests in the nails

� Opens into the eyes

� Houses Ethereal Soul

� Hepar- or hepat: Greek meaning ‘root’

� 500 functions – major role in metabolism

� Hepatocytes: (Gut-Liver Axis)

� Detoxification

� Protein synthesis

� Produces biochemicals for digestion

� Kupffer Cells: (Gut-Immune Axis)

� Immunologic response

� Produces bile: stored in Gall Bladder

� Filters 2 quarts of blood per minute

� 75% of blood received into the liver is venous delivered via the portal vein directlyfrom GI system

� Filtration of toxins is absolutely critical, as the blood from the intestines contains high levels of toxic substances.

� Hepatocytes transform gut-derived compounds into safe by-products then directs them to the Bile for excretion or into arterial blood circulation

� Kupffer cells: phagocytes (think Pac Man)

� Clear portal system of circulating debris

� Limit entry of bacterial toxins and endotoxins into systemic circulation

� Always in a state of low-grade alert

� Exaggerated Immune Response

� Leaky Gut

� Impaired hepatic clearance

� Toxin: substance that precipitates an immune reaction

� Ingestion

� Inhaled

� Topical

� Immune system tolerance:

� Views toxin as “not self” therefore dangerous

� Directly damage structure & function of cells

� Strains liver detoxification system

� Heavy metals: mercury, lead, arsenic

� Chemicals: PCB’s, dioxins

� Pesticides

� Plastics: BPA

� Drinking water: toxic run-off, prescriptions

� Non-organic animal consumption

� GMO’s –Xenobiotics

� Endotoxins: gut bacteria, yeast, parasites

� 212 chemicals typically found

� Widespread exposure: industrial chemicals

� Updated September 2013

� 91 chemicals not previously reported

� 201 tables updated

� 49 chemicals added

� currently 250 chemicals listed

� 770 pages

� www.cdc.gov/exposurereport

� Body Burden: The Pollution in Newborns

� 2005 report on 10 newborn’s cord blood

� Tested for industrial chemicals

� Found 287 total, 200 average/baby

� 47 common consumer product chemicals

� 212 banned or severely restricted chem.

� 28 waste byproducts

� 180/287 carcinogens (human or animal)

� 217/287 toxic to brain & nervous system

� 208/287 cause birth defects or abnormal development (animal tests)

PHASE 1CYTOCROME P450

Modification: fat soluable

toxins

drugs

steroid hormones

Require:

oxygen

vit. B, C, E

glutathione

antioxidants

PHASE 2CONJUGATION

Conjugation:

I.M. transformed

water soluable

excrete via stool/urine

Require:

amino acids

*glutamine

phytochemicals

INTERMEDIARY

METABOLITES

Free RadicalsAntioxidants

� Brain fog – poor focus/concentration

� Fatigue – exhaustion

� Body aches - headaches

� Sensitivity to odors

� Digestive issues: bloating, nausea

� Tingling of extremities

� Weight gain - difficulty losing weight

� Feeling heavy, puffy, swollen

� Depression, irritability, apathy

� Liver Qi Stagnation

� Liver Blood Stasis

� Liver-Fire

� Liver-Wind

� Damp-Heat in Liver-Gall Bladder

� Deficiency of Liver-Blood

� Liver Yang Rising

� Liver Invading Spleen

� Liver Invading Stomach

� Qi Stagnation-distention, n/v, belching, gas, appetite changes, diarrhea, constipation, cramps, bitter taste, melancholy, irritability, impatience, PMS, irregular periods, pain

� Liver Blood-vomiting Blood, clots, headaches, floaters, menstrual >/<, muscle weakness

� Liver Wind/Fire-dizziness, tics, tremors, numbness, tinnitus, red eyes, high temp

� Damp-discharges, itching, dark urine,

� Detoxification Questionnaire� Part 1: Medical Symptom Questionnaire (MSQ)

measures minimal/moderate/elevated toxic load

� Part 2: Xenobiotic Tolerability Test (XTT)

A chemical compound (as a drug, pesticide, or carcinogen) that is foreign to a living organism

� Nutritional

� Herbal/neutraceutical

� Clay

� Rebounding

� Acupuncture

� Microcurrent

� Color

Functional Medicine resources:

Drs. Susan Blum, Mark Hyman, Diana Schwarzbein

� Complete Detox Elimination Diet

� 10-21 days

� Gluten, dairy, soy, corn, peanuts, oranges

� Processed foods-sugar, trans-fats

� Alcohol, caffeine, coffee, chocolate

� Incorporate Healing Foods

� Support Phase I & II: Vit. A, B’s, C, phytonutrients

� Reduce Inflammation: Omega 3’s

� Heal Gut: Vit. A, zinc, antioxidants, fermented

� Blood Sugar: all of the above

� Support Phase 1-2 Detox Pathways� Advaclear: Metagenics

� Liver Formulas� Healthy Liver Formula: herbal tincture (HerbPharm)

� Cell Food: 8 drops/8 oz. H2O/3 X day� Generates bio-available O2

� Reduces free radicals

� Eliminaid: stellar bowel formula

� Glutathione , alpha lipoic acid

� Zinc

� Green algae

� Soluble fiber

� PGX: Natural Factors (pgx.com)

� Clay baths/foot soaks, internal ingestion

� magneticclay.com

� Practitioner supervised chelation

� Needak rebounders

� Improves digestion

� Improves elimination of cellular waste

� Accelerates metabolism

� Increases O2 uptake

� Increases cellular respiration

� Promotes detox via lungs, skin, lymph

� Does not stress joints

� 2 minutes of rebounding flushes lymphatics

� Microcurrent Pads:

� Ch.A: Liv-13 Ch.B: CV 12-6

� Intensity ~ 50-100uA

� Ch.A: 50, 40, 284, 57, 49 / Ch.B: 35 (13, 38)

� 5-7 minutes per frequency

� Acupuncture:

� Bilateral: ST-25,36, Sp-15, K-14, SJ-5, GB-41

� Auricular: Shen men, Point zero, Liver

� Yin tang

� Cell Food

� Lumina Health 1-800-749-9196 luminahealth.com

� Rebounders

� Needak 1-800-232-5762 needak-rebounders.com

� Clay

� L L Magnetic Clay 925-968-1571 magneticclay.com

� Energique (Eliminaid)

� 1-800-869-8078

� Emerson Ecologics

� 1-800-654-4432 emersonecologics.com