Council of Councils

NIH Update September 24, 2013

Lawrence A. Tabak, DDS, PhD

Principal Deputy Director, NIH

Department of Health and Human Services

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NIH Update

Budget Update

Biomedical Research Workforce

BRAIN

Big Data

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NIH Update

Budget Update

Biomedical Research Workforce

BRAIN

Big Data

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NIH Extramural & Intramural Funding FY 2013 Full-Year CR Level: $29.1 Billion

Spending

at NIH

Spending Outside NIH

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$35

$30

$25

$20

$15

$10

$5

$0

(In

Billio

ns)

Appropriation Appropriation in 1998 Dollars

NIH Program Level in Appropriated Dollars and Constant 1998 Dollars

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S

ucce

ss R

ate

5%

10%

15%

20%

25%

30%

35%

40%

45%

?

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78

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Fiscal Year 6

Grant Success Rates FY 1978-2013

Source: Biology Boom Goes Bust.

Ch

an

ge f

ro

m 2

01

2-2

01

3

20%

15%

10%

5%

0%

-5%

-10%

China

Germany Japan S. Korea

Canada

U.S.

Cell 154, July 3, 2013

Scientific Research & Development Spending Change from 2012 to 2013

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NIH Update

Budget Update

Biomedical Research Workforce

BRAIN

Big Data

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Biomedical Research Workforce

Unprecedented scientific opportunities; profound implications For expanding our understanding of biology Improving health

Need to attract, retain, best & brightest researchers Numbers sufficient to carry out exciting work Broadly representative of our societies Gender Race Specialty training

Well-mentored and encouraged to collaborate – and innovate

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Strengthening the Workforce at NI H: Continuing Challenges

Increasingly difficult to launch traditional, independent academic research careers Rising numbers of PhDs Number of established researchers staying in field longer

Lengthier training periods, relatively low early career salariemake profession less attractive

Training programs offer little preparation for careers outsidacademia

Efforts to increase diversity less successful than we had hoped<;

s,

e

NIH Advisory Council to the Director (ACD): Working Groups assigned; recommendations coming 10in

Biomedical Research Workforce Working Group: Recommendations

Graduate Students: enhanced training for multiple

career outcomes

Postdoctoral Researchers: shorten pathway to

independent career; increase support for training;

improve pay, benefits

Information Analysis: improve tracking of career

outcomes, workforce analysis

Staff Scientists: promote their value, stature

Diversity of the Workforce: needs urgent attention

Physician Scientists: conduct further study

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BEST Program:

Broadening Experiences in Scientific Training

Seeks innovative approaches to complement traditional research training at NIH-funded institutions

Encourages institutions to leverage funds with

Existing institutional offices, programs

Local resources outside the institution, or that partner with industry/other entities

Must include rigorous analysis to demonstrate impact Proven approaches will be widely disseminated

throughout biomedical research community Awardees will meet to exchange ideas

Applications currently being reviewed http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-022.html

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Biomedical Research Workforce Working Group: Recommendations

Graduate Students: enhanced training for multiple

career outcomes

Postdoctoral Researchers: shorten pathway to

independent career; increase support for training;

improve pay, benefits

Information Analysis: improve tracking of career

outcomes, workforce analysis

Staff Scientists: promote their value, stature

Diversity of the Workforce: needs urgent attention

Physician Scientists: conduct further study

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Diversity Initiative: Overarching Strategy

Four interrelated approaches will be implemented:

NIH Building Infrastructure Leading to Diversity (BUILD) Program

National Research Mentoring Network (NRMN)

Ensuring Fairness in Peer Review

Increased Engagement by all NIH Leadership

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Biomedical Research Workforce Working Group: Recommendations

Graduate Students: enhanced training for multiple

career outcomes

Postdoctoral Researchers: shorten pathway to

independent career; increase support for training;

improve pay, benefits

Information Analysis: improve tracking of career

outcomes, workforce analysis

Staff Scientists: promote their value, stature

Diversity of the Workforce: needs urgent attention

Physician Scientists: conduct further study

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Working Group on the Physician* Scientist Workforce

Charge

Analyze current composition of workforce to understan d consequences of current funding policies

Assess needs, career opportunities available to support physician-scientist trainees in diverse biomedical resear ch sectors

Identify incentives, barriers to MDs, DDSs, and

DVMs entering and sustaining scientific activities

Recommend ways to support sustainable, diverse clinical research infrastructure

Final Report to ACD: June 2014

*Includes physicians, dentists, veterinarians 16

NIH Update

Budget Update

Biomedical Research Workforce

BRAIN

Big Data NIH BRAIN

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WHO, 2008

Brain Disorders: The Need Is Great

Brain disorders: #1 source of disability in U.S.

> 100 million Americans affected

Rates are increasing: autism, !lzheimer’s disease, and in our soldiers PTSD and TBI

Costs are increasing: annual cost of dementia ~$200B

Already equals cost of cancer and heart disease

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Mechanisms of brain disease

Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative

Goal: Accelerate new technologies to

Produce real-time pictures of complex neural circuit

Visualize rapid-fire interactions of cells at the speed thought

Promise: Open new doors to understanding

How brain function is linked to human behavior and learning

s

of

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NIH BRAIN Initiative: Process

Plan to be developed by a working group of the Advisory Committee to the Director, NIH

Selected for visionary leadership, expertise

Charged with articulating scientific goals, developing plan

Including timetables, milestones, costs

Informed by experts across sectors and disciplines – assisted by NIH Blueprint for Neuroscience Research

NIH BRAIN Working Group

Has sought broad input; hold open meetings, workshops

Delivered interim report on high‐priority areas for FY14 funding in summer 2013;will issue final report, June 2014

Public can receive updates, contribute to discussion, at http://www.nih.gov/science/brain/

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NIH Update

Budget Update

Biomedical Research Workforce

BRAIN

Big Data

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Myriad Data Types

‘Omic Imaging

Phenotypic Clinical 23

Six Big Problems to Solve

1. Locating the data

2. Getting access to the data

3. Extending policies and practices for data sharing

4. Organizing, managing, and processing biomedical Big Data

5. Developing new methods for analyzing biomedical Big Data

6. Training researchers who can use biomedical Big Data effectively

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NIH is Tackling the Big Data Problem

New NIH Leadership Position Reporting to NIH Director

Associate Director for Data Science (ADDS)

New Internal NIH Governing/Oversight Bodies

Scientific Data Council (ADDS)

Administrative Data Council (CIO)

New Trans-NIH Initiative

Big Data to Knowledge (BD2K)

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Big Data: Challenges for Biomedicine

NIH’s Big Data to Knowledge (BD2K) program, starting in FY 2014, will: Facilitate the broad use and sharing of large, complex

biomedical data sets through the development of policiesresources and standards Develop and disseminate new analytical methods and

software Enhance training of data scientists, computer engineers,

and bioinformaticians; and Establish Centers of Excellence to address biomedical

analytics, computational biology, and medical informatics

,

.

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NIH…Lawrence.Tabak@nih.gov

Turning Discovery Into Health

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