Cortical Structures of the Limbic System Most notable structuresPrimary function Orbitofrontal...

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Cortical Structures of the Limbic System Most notable structures Primary function Orbitofrontal gyri Very diverse Cingulate gyrus Emotion Isthmus Emotion + Memory Parahippocampal gyrus Memory Uncus Olfaction

Transcript of Cortical Structures of the Limbic System Most notable structuresPrimary function Orbitofrontal...

Cortical Structures of the Limbic System

Most notable structures Primary functionOrbitofrontal gyri Very diverseCingulate gyrus EmotionIsthmus Emotion + MemoryParahippocampal gyrus Memory Uncus Olfaction

Subcortical Structures of the Limbic System

Most notable structures:Septal nucleiNucleus accumbensMammillary bodyAmygdalaDorsal thalamusHabenulaHippocampal formation

Most notable efferent pathways:FornixStria terminalisVentral amygdalofugalMammilothalamic

Hippocampal Formation

Afferent PathwaysPerforant

AlvearFornix

Efferent PathwaysFornix

Amygdaloid Complex

Afferent PathwaysCingulum

Stria TerminalisLateral oflactory stria

Efferent PathwaysStria TerminalisAmygdalofugal

Septal Nuclei & Nucleus Accumbens

Septal PathwaysMFB (A&E)

Stria terminalis (A)Fornix (A&E)

Stria medullaris (E)

Nuc. Acc. PathwaysMFB (A&E)

Stria terminals (A)Fornix (A)

Learning and Memory

Associative Learning Formation of associations between 2 features in the environment

Nonassociative LearningExperience produces changes in the magnitude of the response

Hebb’s Postulate:

Cells that fire togetherwire together; Cells thatfire out of sync lose theirlink

Cellular Mechanisms of Memory

Long-Term Potentiation Enhancement of synaptic efficacy following strong stimulation