Correlation between therapy with local anesthetics and plasma levels of lanthanides
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s268 CORRELATION BETWEEN TYEKAPY WITH LOCAL ANLSTHETICS AND PLASMA LEVELS OF LANTHANIDES Collecchi*, Pa010 Rruzzi*, Maur~~Ma,'sapl,a Oddone*,, $~~~%~~'~~ and Ambrogio Mazzucotelli: Istituto Nazionale per la Ricerca sul Cancro, Department of General Chemistry, University of Pavia, and Inst- itute of General Chemistry, University of Genoa, Italy. Local anesthetics exert their pharmacologic effect by blocking nerve impulse propagation. Although the molecular mechanisms of these drugs is not fully understood, it is widely accepted that they act on cell membranes presumably by increasing their permeability to osmotically active particles. Their ability to potentiate cell killing by hyperthermia has su gested their po- tential usefulness in cancer therapy. Competition of La 3Q for calcium bind- ing sites and its ability to depress electric potentials of nerves and neuromus$ular function are well known. Furthermore, recent studies suggest that La3 has a stronqer influence on cell membranes characteristics than procaine (L.J. Anghileri et al.: Arch. Geschwulstforsch. 53,4,S.335-339, 1983). In light of these findings, the objective of our study was the eval- $9: ~~3~"eN~5~ec~,~r.p~~§~. ine $Qerapy on plasma levels of Lanthanides Lu 1. Samples of olasma from 8 Patients with epicondylytis, ages 45 to 58, were analyzed before and after 3 and 7 days of procaine therapy, and compared with plasma samples from 30 healthy volunteers. Plasma levels were measured by Neutron Activation. The results indicate significantly higher plasma levels of all Lanthanides in the 8 patients before treatment as compared to the 30 healthy controls. Further- more, a significant increase in La3+ was observed after 7 days of procaine therapy. This preliminary study suggests that endogenous plasma levels of Lanthanides are affected by inflammatory conditions, and that procaine therapy influences La3+ plasma concentrations. (Supported by C.N.R. grant, N.82.02043.53) RESPIRATORY RESWNSE TC POSTOPERATIVE PAIN TRFATMENT. i 402 Poster J. Schwab', F. Schimek, W. Junginger' and R. Schorer', Ee- ’ Monday pa&ment of Anesthesiology, University of Fberhard Karl, Cascade 18 D-74 TLibinqen, Germany Aim of investigation:The effect of postoperative pain treatment by neural block and narcotic analgesic upon respiration was evaluated in pa- tients undergoing elective cholecystectomy.Respiration remained unchanged after regional anesthesia; the narcotic sufficient for pain relief depres- sed breathing, however. Methods: Twelve patients were premeditated with atropine and flunitraze- pam. Capncqraphic CO2 curve and PaC02 was monitored before, during and after halothane - nitrous oxide anesthesia. Endotracheal intubation was facilitated with thiobarbital and succinylcholine; for muscle relaxation pancuronium was injected. Ventilation was maintained at a PaCO2 of 30-38 torr. Halothane was discontinued at least 25 minutes, nitrous oxide at least 7 minutes prior to extubation. Patients complaining of pain were ad- ministered either intercostal blocks (n=4; 0.38% bupivacaine 4 ml: Th5-11) or pentazccine (n=4; 30 mq iv). PaC02 and capnographic response to pain treatment was compared within each group by paired t-test. Results: The patients were observed for one hour after treatment began and all of them were relieved of pain. Respiratory depression occured in pentazccine receivinq patients (p(O.05). Conclusion: Neural blockade appears to be the preferable managment of postoperative pain after upper abdcminal surgery.
Transcript of Correlation between therapy with local anesthetics and plasma levels of lanthanides
s268 CORRELATION BETWEEN TYEKAPY WITH LOCAL ANLSTHETICS AND PLASMA LEVELS OF LANTHANIDES Collecchi*, Pa010 Rruzzi*, Maur~~Ma,'sapl,a Oddone*,, $~~~%~~'~~
and Ambrogio Mazzucotelli: Istituto Nazionale per la Ricerca sul Cancro, Department of General Chemistry, University of Pavia, and Inst- itute of General Chemistry, University of Genoa, Italy.
Local anesthetics exert their pharmacologic effect by blocking nerve impulse propagation. Although the molecular mechanisms of these drugs is not fully understood, it is widely accepted that they act on cell membranes presumably by increasing their permeability to osmotically active particles. Their ability to potentiate cell killing by hyperthermia has su gested their po- tential usefulness in cancer therapy. Competition of La 3Q for calcium bind- ing sites and its ability to depress electric potentials of nerves and neuromus$ular function are well known. Furthermore, recent studies suggest that La3 has a stronqer influence on cell membranes characteristics than procaine (L.J. Anghileri et al.: Arch. Geschwulstforsch. 53,4,S.335-339, 1983). In light of these findings, the objective of our study was the eval-
$9: ~~3~"eN~5~ec~,~r.p~~§~. ine $Qerapy on plasma levels of Lanthanides
Lu 1. Samples of olasma from 8 Patients with epicondylytis, ages 45 to 58, were analyzed before and after 3 and 7 days of procaine therapy, and compared with plasma samples from 30 healthy volunteers. Plasma levels were measured by Neutron Activation. The results indicate significantly higher plasma levels of all Lanthanides in the 8 patients before treatment as compared to the 30 healthy controls. Further- more, a significant increase in La3+ was observed after 7 days of procaine therapy. This preliminary study suggests that endogenous plasma levels of Lanthanides are affected by inflammatory conditions, and that procaine therapy influences La3+ plasma concentrations. (Supported by C.N.R. grant, N.82.02043.53)
RESPIRATORY RESWNSE TC POSTOPERATIVE PAIN TRFATMENT. i 402 Poster J. Schwab', F. Schimek, W. Junginger' and R. Schorer', Ee- ’ Monday pa&ment of Anesthesiology, University of Fberhard Karl, Cascade 18 D-74 TLibinqen, Germany
Aim of investigation: The effect of postoperative pain treatment by neural block and narcotic analgesic upon respiration was evaluated in pa- tients undergoing elective cholecystectomy. Respiration remained unchanged after regional anesthesia; the narcotic sufficient for pain relief depres- sed breathing, however.
Methods: Twelve patients were premeditated with atropine and flunitraze- pam. Capncqraphic CO2 curve and PaC02 was monitored before, during and after halothane - nitrous oxide anesthesia. Endotracheal intubation was facilitated with thiobarbital and succinylcholine; for muscle relaxation pancuronium was injected. Ventilation was maintained at a PaCO2 of 30-38 torr. Halothane was discontinued at least 25 minutes, nitrous oxide at least 7 minutes prior to extubation. Patients complaining of pain were ad- ministered either intercostal blocks (n=4; 0.38% bupivacaine 4 ml: Th5-11) or pentazccine (n=4; 30 mq iv). PaC02 and capnographic response to pain treatment was compared within each group by paired t-test.
Results: The patients were observed for one hour after treatment began and all of them were relieved of pain. Respiratory depression occured in pentazccine receivinq patients (p(O.05).
Conclusion: Neural blockade appears to be the preferable managment of postoperative pain after upper abdcminal surgery.
