Corporate Capabilities 2019 -...
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Application Notes ♦ See page 60 A A A A A A Ap p p pp p p pl l l l l l l li i i i i i ic c c ca a a at t t t t ti i i i i i io o o on n n n N N N N N N No o o ot t t t t te e e es s s s ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ S S S S S S Se e e ee e e e p p p pa a a ag g g ge e e e 6 6 6 6 6 6 60 0 0 0 0 0 0 Corporate Capabilities 2019 A Guide to Leading Separation Science Suppliers
Transcript of Corporate Capabilities 2019 -...
Application Notes ♦ See page 60AAAAAAApppppppplllllllliiiiiiiccccaaaattttttiiiiiiioooonnnn NNNNNNNooootttttteeeessss ♦♦♦♦♦♦♦♦ SSSSSSSeeeeeeee ppppaaaaggggeeee 66666660000000
Corporate Capabilities
2019A Guide to Leading Separation Science Suppliers
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Corporate CapabilitiesCorporate Capabilities2 0 1 9
Corporate Profiles
6 Advanced Chemistry
Development, Inc. (ACD/Labs)
8 Analytical Sales & Services, Inc.
10 Antec Scientific
11 Bal Seal Engineering, Inc.
12 Biotech USA LLC
13 CDS Analytical
14 CEM Corporation
15 Chem Service, Inc.
16 Chiral Technologies, Inc.
17 Cornerstone Scientific
18 Ellutia
19 Fritsch Milling & Sizing, Inc.
20 Gerstel, Inc.
21 Gilson, Inc.
22 Hamilton Company
24 Horizon Technology/ Biotage
25 Imtakt USA
26 LECO Corporation
27 LGC Standards
28 Macherey-Nagel
29 Markes International
30 MilliporeSigma
32 Molex
33 Neta Scientific Inc.
34 OI Analytical
35 Parker Hannifin
36 PerkinElmer, Inc.
37 Peak Scientific
38 PharmaFluidics
39 Photonis Scientific, Inc.
40 Pickering Laboratories, Inc.
41 PSS Polymer Standards
Service Inc.
42 Postnova Analytics Inc.
43 Power4, LLC
44 Proton OnSite
45 Restek Corporation
46 SepSolve Analytical Ltd
47 Shodex/Showa Denko
America, Inc.
48 Shimadzu Scientific
Instruments
50 SilcoTek Corporation
51 SiliCycle, Inc.
52 Sorbent Technologies, Inc
53 Tosoh Bioscience LLC
54 UCT, Inc.
55 Valco Instruments Co., Inc.
(VICI)
56 YMC America, Inc.
58 Wyatt Technology
59 ZirChrom Separations, Inc.
Application Notes
60 Medical/Biological
62 Environmental
63 Pharma/Drug Discovery
66 Calendar
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 5www.chromatographyonline.com
6 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Advanced Chemistry Development, Inc.
(ACD/Labs)8 King Street East, Suite 107
Toronto, Ontario, Canada
M5C 1B5
T E L E P H O N E
+1 4163683435
E - M A I L
W E B S I T E
acdlabs.com
Y E A R F O U N D E D
1994
Advanced Chemistry Development, Inc. (ACD/Labs)
Major Products/Services ⦁ ACD/AutoChrom—comprehensive
method development and optimization
software that supports a Quality by
Design (QbD) approach based on
chromatographic principles. From
strategy creation and investigation
of maximum chromatographic space
to execution of screening runs and
identification of the optimal method.
Optional instrument control for Agilent
ChemStation and Waters Empower.
⦁ ACD/Method Selection Suite—method
simulation software that combines
physicochemical property predictions
with method development tools to
rationally optimize key separation
parameters, define better starting
conditions, and estimate retention
times
⦁ Luminata—software for the efficient
and comprehensive management
of impurity data. Establish effective
process and analytical impurity
control strategies based on live
chromatographic and spectral data and
route knowledge, in a purpose-built
environment.
Company Description Advanced Chemistry Development, Inc. (ACD/Labs) is an
informatics company that develops and commercializes
solutions in support of R&D. Our software platforms unify
analytical and chemical information in a collaborative
environment, and provide tools that enable scientists to
extract, capture, and apply knowledge from analytical
experiments and predicted molecular property data. We
integrate with existing informatics systems and undertake
custom projects including enterprise-level automation.
We offer more than two decades of success helping
organizations accelerate R&D and leverage corporate
intelligence. ACD/Labs provides worldwide sales and support.
Chief Chromatographic Techniques Supported⦁ HPLC
⦁ UHPLC
⦁ LC–MS
⦁ GC–MS
⦁ LC–MS/MS
Markets Served ACD/Labs tools support R&D in various industries including
pharma and biotech, chemicals, consumer goods, agrochemi-
cals, petrochemicals, and government.
Simulate OptimalConditions and
Test Robustness
Store andReportMethod
Screen Databases ofReference Methods
Design a MethodDevelopmentStrategy
Perform Screeningand OptimizationExperiments
SelectMethodConditionsRationally Select
and Justify All
Method Conditions
1
2
3
4
5
6Column
pH Buffer
C D
A4 5
6 7
B
Learn more www.acdlabs.com/methdev
ACD/Labs chromatography software uniquely offers the capabilties to:
• Process and interpret chromatographic data from virtually all instrument vendors
• Algorithmically track peaks to follow all components between experiments
A registered trademark of Advanced Chemistry Development, Inc. (ACD/Labs)®
Software to streamline method development using in silico optimization
Robust Methods, Fewer Injections
Enable a straightforward, stepwise method development approach
that follows Quality by Design (QbD) principles
8 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Analytical Sales & Services, Inc.
179 Rt 206,
Flanders, NJ 07836
T E L E P H O N E
(973) 616-0700
F A X
(973) 616-0133
E - M A I L
W E B S I T E
www.analytical-sales.com
N U M B E R O F E M P L O Y E E S
16
Y E A R F O U N D E D
1988
Analytical Sales & Services, Inc.
column heater
⦁ MultiSleeve multiple column heater
controller
⦁ MonoSleeve single column heater controller
⦁ PowerSelector temperature-controlled
column selector
⦁ FlexChrom 1/16” flexible stainless-steel
tubing
⦁ UHPLC fingertight fittings
⦁ TrueTaper 96-well collection plates
⦁ 96-well cap mats
⦁ DBS – Dried Blood Spot pneumatic
card punch
⦁ Canary-Safe solvent safety products
⦁ Paradox – parallel synthesis and
photoredox optimization plates
⦁ Lumidox – LED photon generator for
photoredox applications
⦁ EquaVAP – 96-, 54-, 48- and 24-well
blowdown solvent evaporators
⦁ Sentinel fluid level monitor
⦁ SiliGuard low-bind coating for poly-
propylene collection plates
Other chromatography-related products:
⦁ HPLC/LC–MS columns: Wide selection
of hardware and sorbents available for
analytical, narrow-bore, microbore, prep
and semi-prep applications
⦁ Direct-connect columns
⦁ Sample and solvent preparation products
⦁ Automated valves for injection,
selection and switching
Facility Our corporate headquarters are in Flanders,
New Jersey. All operations are located within
this facility, including R&D, manufacturing,
applications development, and customer
training.
Company Description Analytical Sales and Services develops and manufactures
new and custom instruments, parts, and devices. As a leading
supplier of chromatography products, our focus is based on each
customer’s unique needs. Our success is based on providing
chromatographers with high quality products and service that
make their daily analysis more accurate, reliable, and valuable.
Celebrating 30 Years! Analytical Sales & Services first opened
its doors for business on March 1, 1988 —and we’ve been
growing ever since. In 2016 we moved out of our 14,000 sq.
ft. space and into a 22,500 sq. ft. space now holding our R&D,
Engineering, Manufacturing, and Corporate offices.
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ LC/LC–MS
⦁ High-Throughput Assays
⦁ High-Throughput Equipment (HTE)
⦁ Chromatography Supplies
Markets Served Our major focus continues to be the HPLC and
chromatography-related markets of the pharmaceutical and
chemical industry, with a focus on R&D.
Major Products/Services ⦁ Hot Sleeve Column Heaters
⦁ Cold Sleeve Column cooler/heater
⦁ AgileSleeve small diameter flexible
Products for ScienceCelebrating 30 Years
of ExcellenceBor
n in NEW JERSEY,
Made in the USA
Analytical Sales & Services, Inc.179 Route 206 • Flanders, NJ • 07836
Phone: 973-616-0700 • Fax: 973-616-0133
Email: [email protected] • Web: www.analytical-sales.com
Online Store: www.analytical-sales.biz
Parallel Synthesis & PhotoredoxOptimization Plates
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10 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Antec ScientificOne Boston Place,
201 Washington Street,
Boston, MA 02108
T E L E P H O N E
(888) 572-0012
E - M A I L
W E B S I T E
www.antecscientific.com
Y E A R F O U N D E D
1990, since 2010 in USA
Electrochemical Reactors
for MS and Synthesis
With the introduction of the ROXY™ EC
system, REDOX reactions can be monitored
directly by mass spectrometry (MS). The on-
line coupling of electrochemical reactors with
MS (EC–MS) has found many application
areas from proteomics, lipidomics, drug
metabolism, drug stability testing, to
environmental degradation. Another
emerging application of Antec’s flow and
batch reactors is in Flow Chemistry for rapid
synthesis of drugs, metabolites, degradants
(reference materials).
SenCell™ for Detection
Proprietary Adjustable Spacer Technology
(AST) for highest sensitivity (US Patent
9,310,330)
μ-PrepCell 2.0™ for Reactions
Redox reactions upfront MS: disulfide
bond reduction in proteins, mimicking
drug metabolism, drug stability testing/
degradation
SynthesisCell™ for Synthesis
Batch reactor for rapid synthesis of mg
quantities of products
Antec Scientific
Company Description For over 27 years, Antec Scientific has been the world
leading supplier of analytical instrumentation based on
electrochemistry (EC). Antec’s line of instruments include
electrochemical detectors (ECD), analyzers built on HPLC-ECD
and electrochemical reactors for use with MS (EC–MS) and
synthesis.
Electrochemical Detectors for HPLC
The DECADE™ line of ECDs (Elite™ and Lite™) have become the
benchmark in detection and can be used with any third party
(U)HPLC system. Different flow cells are available to cover a
broad range of applications from the analysis of antibiotics to
sugars or pharmaceuticals.
Dedicated Analyzers
The ALEXYS™ Analyzers based on HPLC with ECD are turnkey
instruments built for highest performance and to ensure ease-
in-use. Guaranteed applications have been developed with
the ALEXYS Neurotransmitter Analyzer for sensitive analysis in
microdialysates and brain tissue. Other application areas are
in clinical/diagnostics, food/beverage, environmental, and
drugs/pharmaceuticals analysis.
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 11www.chromatographyonline.com
Markets Served Bal Seal Engineering products improve
the performance of liquid handling,
chromatography, and diagnostic equipment.
The company’s Bal Seal® spring-energized
seals ensure performance accuracy and
product consistency in multi-channel
pipettors, and also enable designers of
HPLC, UHPLC, SFC, and diagnostic pumps
to answer end user demand for better
throughput, sample resolution, and reduced
equipment downtime. The company’s Bal
Spring® canted coil springs ground and
efficiently transfer electrical current in mass
spectrometers and other spectroscopy
instruments.
Major Products/Services Bal Seal Engineering designs seals that
deliver reliable, long-term performance in
liquid chromatography pumps, and springs
with mechanical fastening and electrical
conducting properties. The company’s
reciprocating flange seal combines the
Bal Spring® energizer with advanced
polymer formulations to promote more
uniform wear and longer service life.
In UHPLC pressures of 15,000 psi and
above at temperatures up to 80 °C, it
seals consistently for millions of cycles.
The canted coil Bal Spring® enables
mass spec designers to achieve constant
ion alignment, no contamination, more
accurate m/z measurement and minimal
downtime.
Facility Bal Seal Engineering designs and
manufactures its products in two U.S.
locations—Foothill Ranch, CA, and
Colorado Springs, CO. The company has
built a network of engineering and sales
offices worldwide, with locations in The
Netherlands, United Kingdom, Germany,
Czech Republic, Hong Kong, and Japan.
Bal Seal Engineering, Inc.
Company Description Bal Seal Engineering, Inc. makes custom components that
drive tomorrow’s technologies. The company is a leading
global provider of custom-engineered sealing, connecting,
conducting and EMI/RFI shielding and grounding solutions for
analytical equipment, and it applies 60+ years of problem-
solving experience to help OEMs and tier suppliers address
their toughest engineering challenges. Products employ
unique Bal Spring® canted coil spring technology to promote
enhanced equipment performance and reliability.
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ UHPLC
⦁ LC×LC
⦁ SFC
⦁ IC
⦁ GPC
⦁ Prep LC
⦁ LPLC
Bal Seal Engineering, Inc.19650 Pauling
Foothill Ranch, CA 92610
T E L E P H O N E
(Toll-free) (800) 366-1006
U.S.: (949) 460-2100
Europe: +31 20 638 6523
Asia: +(852)-28681860
F A X
U.S.: (949) 460-2300
Europe: +31 20 625 6018
Asia: +(852) 22956753
E - M A I L
W E B S I T E
www.balseal.com
N U M B E R O F E M P L O Y E E S
600 (worldwide)
Y E A R F O U N D E D
1958
12 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Markets Served ⦁ Instrument Developers
⦁ OEM customers
⦁ Distributors
⦁ End users
Major Products/Services ⦁ Degassing & Debubbling
⦁ DEGASi Stand Alone Degassers
⦁ Detectors
⦁ Fittings & Connectors
⦁ HPLC/UHPLC Columns
⦁ Column Hardware
⦁ HPLC Filters & Frits
⦁ Knitted Delay/reaction Coils
⦁ Level Sensor
⦁ Smart Saver – USB Solvent Recycler
⦁ Tubing
⦁ Pumps
⦁ Valves
⦁ OEM Solutions
⦁ Service and Support
Facility Biotech AB (HQ) is situated on the Onsala
peninsula on the Swedish Westcoast near
Gothenburg City and Landvetter Interna-
tional Airport. We operate globally and
have subsidiaries in US and Japan to give
you the best service and support.
Biotech USA LLC
Company Description Biotech are supplying innovative laboratory products to instru-
ment manufacturers, distributors and end-users around the
world. As a Global Premium Distributor for IDEX, we have
special know-how about their assortment and can provide
you with the right mix of products for a successful fluidic
system.
No troubles with bubbles
We specialize in chromatography and finding solutions to
issues with gases and bubbles in fluidic systems. By using
our advanced degassers, the laboratory can optimize the per-
formance of its analytical instruments and chromatographic
equipment. Our degassing solutions save the industry both
time and money by avoiding production disruptions caused
by bubbles in the fluidic lines.
Chief Chromatographic Techniques Supported⦁ HPLC
⦁ UHPLC
⦁ GPC
⦁ Preparative HPLC
⦁ SFC
⦁ Ion Chromatography
Biotech USA LLCPO Box 18796
Minneapolis, MN 55418
T E L E P H O N E
(612) 703-5718
F A X
(866) 682-5816
E - M A I L
W E B S I T E
www.biotechfluidics.com
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 13www.chromatographyonline.com
Major Products/Services 6th generation Pyroprobe™ with DISC
technology is a revolutionary pyrolyzer
with easy sample loading, unparalleled
reproducibility, hybrid Autosampler and
superior resolution. The 2nd generation
stand-alone Thermal Desorption autosam-
pler supports the Peltier electric cooling to
handle C2 to C44 level VOCs with boiling
point up to 350 °C. The 7000C is the in-
dustry’s first Purge and Trap concentrator
that is integrated with PAL System. The
proprietary Type X trap increased the Rela-
tive Response Factor by 10% on average
compared to the industry’s standard Type
K trap.
Facility CDS’s state-of-art facility is located in
Oxford, Pennsylvania. Our production
team utilizes six sigma lean manufacturing
processes and is delivering the products
with the highest quality in the industry.
CDS products passed various safety
regulations, including CE and NRTL. The
phase 2 construction is ongoing to double
the production area.
CDS Analytical
Company Description CDS Analytical is celebrating its 50th anniversary. CDS Analytical
was founded by Dr. Eugene Levy in Nottingham, PA, in 1969.
Over the past 50 years, CDS Analytical has been expanding
its core business from Analytical Pyrolysis to a full range of GC
Sample Introduction methods, including Thermal Desorption,
Purge & Trap, and Dynamic Headspace. As of today, CDS
Analytical gathers world-class engineers and analytical chemists
working together to continue the “Made in USA” legend. We
provide the best tool to our customers in Analytical Chemistry
by packaging our continuous innovations in hardware, software,
technology, and applications into a complete solution.
Chief Chromatographic Techniques Supported ⦁ Analytical Pyrolysis
⦁ Purge and Trap
⦁ Thermal Desorption
⦁ Dynamic Headspace
Markets Served CDS Analytical products have been serving the following markets
as: Polymer, Rubber, Environmental, Aerospace, Automobile,
Chemical Weapon, Energy, Food and Flavor, Forensics, Paper &
Ink, Pharmaceuticals, Semiconductor, Textiles, and Tobacco.
CDS Analytical465 Limestone Road
Oxford, PA 19363
T E L E P H O N E
(800) 541-6593
F A X
(610) 932-4158
E - M A I L
W E B S I T E
www.cdsanalytical.com
Y E A R F O U N D E D
1969
14 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
CEM CorporationPO Box 200,
Matthews, NC 28106
T E L E P H O N E
(704) 821-7015
(800) 726-3331
F A X
(704) 821-7894
E - M A I L
W E B S I T E
www.cem.com
N U M B E R O F E M P L O Y E E S
USA: 245
Elsewhere: 65
Y E A R F O U N D E D
1978
CEM Corporation
Major Products/Services CEM has recently launched a revolution-
ary new system for LC–GC sample prep.
The EDGE Energized Dispersive Extraction
system provides fully automated extraction
in as little as 5 min, including filtration,
cooling, and system washing. The EDGE
combines the processes of Pressurized
Fluid Extraction with Dispersive Solid
Phase Extraction in a single instrument to
yield fast results, regardless of sample size,
matrix, or use of sorbents. The EDGE sup-
ports a wide variety of applications includ-
ing pesticides in foods, total fat extraction,
additives or contaminants in plastics, and
environmental extractions such as EPA
3545A.
Facility CEM’s global headquarters, research labo-
ratories, and manufacturing facilities are
located in Matthews, North Carolina. The
company has subsidiaries in the United
Kingdom, Ireland, Germany, Italy, France,
and Japan as well as more than 50 dis-
tributors worldwide.
Company Description CEM Corporation is a leading global company specializing
in scientific solutions for critical laboratory applications. We
design and manufacture systems for analytical laboratories,
bioscience applications, life sciences, and processing plants
worldwide. Our product portfolio includes innovative
instrumentation for sample preparation for elemental or
chromatographic analysis, chemical synthesis, peptide
synthesis, and other applications.
Chief Chromatographic Techniques Supported ⦁ LC
⦁ LC–MS
⦁ GC
⦁ GC–MS
Markets Served CEM instrumentation is used by chemists, scientists, and
technicians in private industry, as well as leading universities,
analytical laboratories, and research facilities around
the world. We support numerous markets, including the
pharmaceutical, chemical, environmental, applied materials,
food, and petroleum industries, among others.
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 15www.chromatographyonline.com
agencies; food quality control; agricultural
testing and research; life science endeavors;
environmental control and remediation;
college and university work; and the
manufacture of chemicals, pulp and paper,
and alcoholic beverages.
Major Products/Services ⦁ Flame retardants/PBDE
⦁ Metabolite standards
⦁ EPA 535 ESA/OA metabolites
⦁ Explosive residues
⦁ PCB congeners
⦁ Petroleum hydrocarbons
⦁ Fatty acid methyl esters
⦁ High purity inorganics
⦁ Surfactants
⦁ Anti-oxidants
⦁ Ultraviolet inhibitors
⦁ Plasticizers
⦁ Biological stains
⦁ Phthalate standards
⦁ Polynuclear aromatics
⦁ Vitamins
⦁ Carbohydrates standards
⦁ Forensic standards
⦁ Personal care product standards
⦁ Pesticide residue standards
Facility Chem Service’s headquarters are located in
West Chester, Pennsylvania. A global network
of distributors for sales outside the United
States is available for all of our products.
Chem Service, Inc.
Company Description Established in 1962, Chem Service is accredited for ISO Guide
34:2009 and ISO/IEC 17025:2005 and registered and certified
to the ISO 9001:2008 Quality Management System for the
design, development, production, distribution, and servicing of
organic neat and synthetic reference materials. Chem Service, Inc.
produces high purity chemicals for use as reference materials and
for other laboratory purposes. More than 95% of their standards
grade materials have a certified purity of 98.0% or greater and
do not require purity corrections when preparing solutions for
use with EPA, USTM, UST, and numerous other international
methods. Standards grade chemicals are clearly labeled with an
expiration date that is based on years of experience in handling
and testing. Products are packaged in small quantities to
minimize storage, waste, and disposal requirements. Organic and
inorganic chemicals, solutions, and mixtures are available to meet
a wide range of specialized laboratory needs.
Chief Analytical Techniques Supported⦁ GC–FID
⦁ GC–ECD
⦁ GC–TCD
⦁ GC–MS
⦁ HPLC
⦁ FT–IR
⦁ UHPLC–MS
Markets Served Chem Service has thousands of worldwide customers in a
wide range of sectors, including government and regulatory
Chem Service, Inc.
660 Tower Lane,
West Chester, PA 19381
T E L E P H O N E
(800) 452-9994
F A X
(610) 692-8729
E - M A I L
W E B S I T E
www.chemservice.com
Y E A R F O U N D E D
1962
ES45293_LCGCSUPP1218_015.pgs 12.01.2018 01:35 UBM blackyellowmagentacyan
16 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
⦁ Columns packed with sub-2 and 3-μm
particles are available for rapid analyses
of drug candidates.
⦁ Bulk chiral stationary phases are
supplied for process-scale chiral
chromatography.
⦁ The company also provides analytical
method development and custom
separation services.
Facility Chiral Technologies’ headquarters,
including a state-of-the-art technical
center, are located in West Chester, PA.
Chiral Technologies, Inc.
Company Description Chiral Technologies, Inc. is a subsidiary of Daicel Corporation,
the global market leader in enantioselective chromatography,
offering the most extensive portfolio of chiral stationary
phases available on the market. Enantioselective
chromatography is essential to accelerate drug discovery and
development processes. Scientists in the pharmaceutical,
agricultural and food industries, universities, and government
agencies rely on our expertise in enantioselective
chromatography to separate chiral molecules into single
enantiomers in research and development departments, and
QC laboratories to initiate pre-clinical trials.
Chief Chromatographic Techniques Supported ⦁ High-Performance Liquid Chromatography (HPLC)
⦁ Ultra-High Performance Liquid Chromatography (UHPLC)
⦁ Supercritical Fluid Chromatography (SFC)
⦁ Simulated Moving Bed (SMB) technique
Markets Served Chiral Technologies serves the North and Latin American
markets through Chiral Technologies Inc. (West Chester, PA),
the European market through Chiral Technologies Europe SAS
(Illkirch, France), and the Asian market through Daicel Chiral
Technologies India and Daicel Chiral Technologies China, all
wholly owned subsidiaries of Daicel Corporation.
Major Products/Services Daicel chiral columns:
⦁ Revolutionary immobilized CSPs
Chiral Technologies, Inc.800 North Five Points Road
West Chester, PA 19380
T E L E P H O N E
(610) 594-2100
or 800 6CHIRAL
F A X
(610) 594-2325
E - M A I L
W E B S I T E
www.chiraltech.com
N U M B E R O F E M P L O Y E E S
25
Y E A R F O U N D E D
1990
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 17www.chromatographyonline.com
Cornerstone Scientific
Company Description Scientific supply distributor representing innovator brands
that are not carried by large, market-leading distributors.
Technical support from scientists that understand the cus-
tomer’s work and needs.
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ LC–MS
⦁ Gas Chromatography
⦁ Solvent and Sample Filtration
Markets Served ⦁ Pharmaceutical
⦁ Food
⦁ Academic
⦁ Forensic
⦁ Environmental
⦁ Life Sciences
⦁ General Laboratory needs
Major Products/Services HPLC Columns, Incubators, Centrifuges, Pipettors,
Autosampler Vials, HPLC Waste Management Systems,
Filtration for HPLC mobile phase and samples.
Facility Located in Wilmington NC, our first facility contains our
customer service and warehousing.
Cornerstone Scientific8209 Market Street
Wilmington, NC 28411
T E L E P H O N E
(910) 599-9006
E - M A I L
customers@
cornerstonescientific.com
W E B S I T E
www.cornerstonescientific.com
N U M B E R O F E M P L O Y E E S
7
Y E A R F O U N D E D
2018
18 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
⦁ Agro-chemical
⦁ Cosmetics
⦁ Toy production
⦁ High purity gas
⦁ Natural gas
⦁ Environmental testing
Major Products/Services ⦁ 200 Series GC: A compact and versatile
single channel gas chromatograph
⦁ 500 Series GC: A high-speed GC using
resistively heated columns for ultra fast
analysis cycle times
⦁ High Purity Gas Analyzer: A rack-
mounted GC for detecting impurities in
gas to extremely low levels
⦁ 800 Series TEA: Nitro, nitroso, and
nitrogen detector that can be interfaced
with almost any GC
⦁ Ellution Chromatography Data Station:
Software for collecting and processing
data from a GC
⦁ 7000 Flowmeter: A compact handheld
flowmeter for accurately setting flows
on a GC
Facilities Ellutia’s headquarters are located just
outside Cambridge in the UK. This facility
hosts the main research and development
labs and is where all of the instruments
are manufactured and tested. Outside
of the UK, Ellutia also has an office in
Germany and has recently opened a new
dedicated sales and service organization
in the US.
Ellutia
Company Description Ellutia offers a range of gas chromatographs, GC accessories,
software, and consumables. Ellutia’s instruments are designed
and manufactured in the UK at the company headquarters.
The instruments are designed to be more compact, have
greater energy efficiency, whilst still delivering industry stan-
dard analytical performance. Ellutia works closely with its
customers and regularly produces fully customized systems
tailored to their individual requirements rather than just deliv-
ering off the shelf products. It is this working relationship with
customers and the flexibility to adapt that sets Ellutia apart
from other GC manufacturers.
Chief Chromatographic Technique Supported ⦁ Gas chromatography
Markets Served Ellutia’s products can be found in a wide range of industries,
including
⦁ Brewing and malting
⦁ Food testing
⦁ Packaging testing
⦁ Permeation testing
⦁ Education
⦁ Forensic laboratories
Ellutia LtdColston House
200 Lancaster Way Bs Pk
Ely, Cambs
CB63NX
UK
T E L E P H O N E
+44 1353 669916
F A X
+44 1353 669917
E - M A I L
W E B S I T E
www.ellutia.com
N U M B E R O F E M P L O Y E E S
17
Y E A R F O U N D E D
1994
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 19www.chromatographyonline.com
Fritsch Milling & Sizing, Inc.
Company Description FRITSCH is an internationally recognized manufacturer of
application-oriented laboratory instruments for sample
preparation and particle sizing.
Chief Chromatographic Techniques SupportedLaboratory Mills for optimal sample preparation of
chromatographic techniques
Markets Served Worldwide in the following industries: Mining, Construction
materials, Biology, Chemistry, Mechanochemistry,
Agriculture and forestry, Geology/mineralogy, Ceramics/glass
industry, Plastics/textiles, Foodstuffs,
Metallurgy, Environment, Pharmaceuticals
Major Products/Services Particle size reduction, milling, grinding, and analysis of
particle size and shape.
Facility USA headquarters and applications laboratory in North
Carolina. Global headquarters in Germany. Sales offices in
China, Asia Pacific, Russia, and France.
Fritsch Milling & Sizing, Inc.
57 Grant Drive Suite G,
Pittsboro, NC 27312
T E L E P H O N E
(919) 229-0599
E - M A I L
W E B S I T E
www.fritsch-us.com
N U M B E R O F E M P L O Y E E S
100+ worldwide
Y E A R F O U N D E D
1920-Fritsch GmbH
20 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
GERSTEL, Inc.701 Digital Drive, Suite J
Linthicum, MD 21090
T E L E P H O N E
(800) 413-8160
F A X
(410) 247-5887
E - M A I L
W E B S I T E
www.gerstelus.com
www.gerstel.com
Y E A R F O U N D E D
1967
⦁ MultiPurpose Sampler MPS: The GERSTEL
MPS is a highly reliable robotic automa-
tion platform, which provides sample
handing, preparation and introduction.
A large variety of techniques can be
performed by the MPS. These are listed
below.
⦁ Automated SPE: Independent of LC–MS
or GC–MS or combined with sample in-
troduction. Based on standard cartridges.
⦁ Automated DPX: Dispersive SPE tech-
nique for fast, efficient extraction and
concentration of analytes.
⦁ Dynamic Headspace (DHS): Concen-
trates VOCs from liquids or solids.
Ultralow detection limits. DHS Large
sample containers up to 1 L.
⦁ Thermal Desorption Unit (TDU): Highly
flexible, automated analysis of up to
196 samples. Performs thermal
desorption/extraction and pyrolysis.
⦁ Thermal Desorption System (TDS):
Ultra-low detection limits for VOCs and
SVOCs up to n-C40+.
⦁ Twister® Stir Bar Sorptive Extraction
(SBSE): Ultratrace level solvent-less
determination of organic compounds
in aqueous matrices. Up to 1000 times
more sensitive than SPME.
⦁ Cooled Injection System (CIS): Univer-
sal PTV inlet for optimized GC perfor-
mance. High temperature version up to
650 °C, cryostatic cooling.
⦁ Automated Liner EXchange (ALEX): For
samples with a heavy matrix load.
⦁ Automated Centrifugation, Solvent
Evaporation, Weighing, Filtration,
Vortexing, and Bar Code Reading
⦁ Multidimensional GC with Column
Switching: Complex separations using
two or more columns.
⦁ Olfactory Detection Port (ODP): For
GC or GC–MS; complete with voice
recognition, intensity indication, and
peak annotation.
⦁ Preparative Fraction Collector (PFC): For
GC or GC–MS using up to six traps.
Facility Full applications support laboratory at US
headquarters near Baltimore, Maryland, and
a partner applications laboratory in Chicago,
Illinois. Our sales and applications team helps
customers use GC and LC analysis techniques
to solve real-world challenges.
GERSTEL, Inc.
Company Description Gerstel is a world leader in ana-
lytical system automation for GC–
MS and LC–MS instrumentation.
Gerstel’s automation for sample
preparation, sample introduction
and standalone WorkStations is
compatible with all manufactur-
ers of analytical technology. Total
system solutions from Gerstel
provide unique advantages by en-
hancing productivity and system
stability and by improving quality
of results while reducing solvent
use and overall cost.
Chief Chromatographic Techniques Supported ⦁ Autosamplers for GC–MS and
LC–MS
⦁ Automated sample preparation for GC–MS and LC–MS
⦁ Sample Preparation WorkStation for making standards,
preparing dilution series, derivatization, and more
⦁ Automated solid-phase extraction (SPE)
⦁ Dispersive SPE (DPX)
⦁ Solid Phase Micro-Extraction (SPME) and Headspace
⦁ Twister® Stir Bar Sorptive Extraction (SBSE)
⦁ Dynamic headspace and thermal desorption
⦁ PTV and large-volume injection
⦁ Automated Liner Exchange (ALEX)
⦁ Multicolumn/multidimensional GC systems
⦁ Olfactory detection and preparative fraction collection
⦁ Pyrolysis
Markets Served ⦁ Food/Beverage, Flavors & Fragrances
⦁ Personal Care, Cosmetics, and Over-the-Counter Products
⦁ Clinical Research & Forensics
⦁ Electronics, Plastics, Polymers, and Chemicals
⦁ Pharmaceutical, CROs, and Bio-therapeutics
⦁ Environmental and Industrial Hygiene
Major Products/Services ⦁ MAESTRO Software: Intuitive operation software provides
sample prep by mouse-click and productivity tools for auto-
mation. MAESTRO software seamlessly integrates into Agilent
ChemStation/MassHunter or runs in the background on LECO,
Sciex, Thermo Scientific, and other vendors’ systems.
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 21www.chromatographyonline.com
Gilson, Inc.3000 Parmenter Street
P.O. Box 620027
Middleton, WI 53562
T E L E P H O N E
(800) 445-7661
F A X
(608) 831-4451
E - M A I L
W E B S I T E
www.gilson.com
Y E A R F O U N D E D
1947
Gilson, Inc.
Major Products/Services Gilson offers a wide variety of liquid
handling products and services, ranging
from mechanical to automated pipettes,
and all the way to highly customized HPLC
solutions, including:
⦁ Single and multichannel pipettes
⦁ Pipette tips
⦁ Pipette service
⦁ Liquid handling
⦁ Automated qPCR prep
⦁ Preparative HPLC
⦁ LC–MS
⦁ SPE
⦁ GPC
⦁ Control software
⦁ Onsite service solutions
⦁ Protein Extraction
Facilities Gilson, Inc. is located in Middleton, Wiscon-
sin, and is responsible for research, develop-
ment, manufacturing, and sales of Gilson
instrumentation and software. Gilson SAS,
located Northeast of Paris, France, is home
to the famous PIPETMAN product line, in
addition to pipette accessories and pipette
tips. Products and services of Gilson are
offered worldwide, with sales and support
in over 100 countries.
Company Description Gilson is a family owned global manufacturer of liquid handling,
purification, and extraction solutions for the life sciences industry.
We help researchers advance the pace of discovery by creating easy-
to-use lab instruments that improve reproducibility and traceability.
Since 1957, we’ve been developing innovative products, such as
PIPETMAN®. By partnering closely with the scientific community,
we’re continuously advancing our product offerings, and have
added automated pipetting systems and software to our portfolio.
Backed by worldwide R&D, service, and support, we strive to enable
verifiable science and make lab life easier for our customers.
Chief Chromatographic Techniques Supported⦁ Preparative HPLC
⦁ Semi-preparative HPLC
⦁ Centrifugal Partition Chromatography (CPC)
⦁ HPLC pumps
⦁ Photodiode array detectors (DAD)
⦁ Mass spectrometry detector (MS)
⦁ UV-Vis detectors
⦁ Evaporative light scattering detector (ELSD)
⦁ Fraction Collectors
⦁ Solid-phase extraction (SPE)
⦁ Gel permeation chromatography clean-up (GPC)
Markets Served Gilson has a worldwide sales and service network to support the
life science, pharmaceutical, clinical, chemistry, and applied science
markets. Our primary focus is on manual and automated sample
preparation, automated SPE, prep HPLC, and GPC clean-up.
22 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
the pressure stability of silica-based columns.
With Hamilton’s Polymeric Reversed Phase
(PRP™) HPLC columns and resins, the sample
dictates the necessary separation conditions,
not the limitations of the column. Hamilton can
also customize HPLC columns to meet a de-
sired application need. Each product is manu-
factured to achieve the highest level of accuracy.
Chromatography Syringes: Hamilton offers
the most complete selection of syringes on
the market for use in various applications
including GC and HPLC (autosamplers and
manual injection), thin layer chromatogra-
phy (TLC), liquid handling, and life sciences.
Crafting exceptional syringes is an evolving
science, which is why Hamilton is dedicated
to the continuous research and development
of this product line. Hamilton constantly en-
riches its entire syringe offering by either im-
proving existing models or introducing new
ones. Using customers’ needs and feedback
as a guide, we innovate in ways that maxi-
mize flexibility, performance, and value.
Microlab® 600 Diluter/Dispenser: The Mi-
crolab® 600 is a highly precise syringe pump
with a touchscreen interface designed to
quickly and easily dilute and dispense fluids,
while increasing throughput and reducing
cost and wasted buffer. This positive dis-
placement system provides better than 99%
accuracy, independent of a liquid’s viscosity,
vapor pressure, and temperature. The inert
fluid path minimizes sample carryover and is
compatible with harsh chemicals.
Facilities Hamilton Company is a global enterprise with
headquarters in Reno, Nevada; Hopkinton,
Massachusetts; Giarmata, Romania; and Bona-
duz, Switzerland,
and subsidiary of-
fices throughout the
world.
Hamilton CompanyChromatography Products for HPLC and GC
Company Description Hamilton Company is an industry leader in the design and
manufacture of liquid handling, process analytics, robotics, and
automated storage solutions. For 60 years, Hamilton has been
satisfying customer needs by combining quality materials with
skilled workmanship to ensure the highest level of performance.
Hamilton’s lifelong commitment to precision and quality has
earned a global ISO 9001 Certification.
Founded on the technology of analytical Microliter™ and
Gastight® syringes, Hamilton has a broad offering of laboratory
products, including manual and semi-automated precision fluid
measuring instruments, chromatography products, process
sensors, laboratory electrodes, pipettes, and more.
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ Polymeric HPLC columns: reversed phase, anion exchange,
cation exchange, and ion exclusion
⦁ Silica HPLC columns
⦁ GC septa
⦁ Chromatography syringes (HPLC and GC)
Markets Served ⦁ Analytical
⦁ Pharmaceutical
⦁ Biotechnology
⦁ Industrial
⦁ Clinical
⦁ Environmental
Major Products/Services HPLC Columns: Hamilton manufactures 18 types of polymeric HPLC
columns for reversed phase, anion exchange, cation exchange, and
ion exclusion separations, providing a wide range of retention charac-
teristics and performance benefits. Hamilton’s polymer-based HPLC
columns provide maximum inertness and pH stability (0–14) with
Hamilton Company4970 Energy Way
Reno, NV 89502
T E L E P H O N E
(775) 858-3000
(800) 648-5950
F A X
(775) 856-7259
E - M A I L
W E B S I T E
www.hamiltoncompany.com
Y E A R F O U N D E D
1953
© 2018 Hamilton Company. All rights reserved.
Your sample depends on it
More than 50 years of precision liquid
handling experience. Proven accuracy.
Continuous research and development.
Choose an autosampler syringe from
Hamilton Company and be confident
in your results.
Hamilton offers a line of syringes
designed to work with a wide range
of the most popular autosamplers
from Agilent, CTC PAL, Spark Holland,
and more. Each syringe is expertly
handcrafted to maximize sample
integrity, process efficiency, and
new long-life syringe technology.
For more information, visit
www.hamiltoncompany.com/autosampler
or call toll free 1-888-525-2123.
24 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
sample preparation can be experienced by
laboratories in a broad range of industries,
including: environmental, food, beverage,
and agricultural, industrial and chemical,
and petrochemical.
Major Products/Services With expertise derived from over two
decades of experience in automated solid
phase extraction, Horizon Technology has
developed a full line of instruments and
consumables to meet the expansive needs
of our customers. We offer manual and
automated disk extraction systems, both
with unmatched versatility, ease-of-use,
and rapid high-throughput SPE capabilities
for many sample types. For smaller
volume samples, we offer an automated
cartridge extraction system with an
intuitive interface and scalability to meet
the throughput demands of the laboratory.
We also offer solvent evaporation and
concentration systems, and a wide range
of consumables including: SPE disks and
cartridges, pre-filters, and disk holders.
Facility Horizon Technology products are manu-
factured in Salem, New Hampshire. The
state-of-the-art facility is ISO 9001 certified
and features a chemistry lab with high
cleanliness requirements to support ap-
plication development, fully staffed engi-
neering and quality control groups, and a
complete setup for system assembly and
service depot repair.
Horizon Technology, part of Biotage
Company Description Horizon Technology, now a part of Biotage, is a world leader
in automated sample preparation, pioneering advancements
in organic sample preparation. From solid-phase extraction
systems that extract over 117 volatile and semi-volatile
compounds in a single pass and reduce solvent usage by up
to 90%, to the first automated solution that combines rapid
extract drying and evaporation in one system, we’ve helped
laboratories maximize their productivity, while reducing cost
and space. On December 6th 2017, Horizon Technology
entered into an acquisition agreement with Biotage, LLC. The
acquisition is complementary to Biotage’s existing offering,
which allows both companies to strengthen their product
portfolios and market knowledge.
Chief Chromatographic Techniques Supported ⦁ GC
⦁ GC–MS
⦁ GC–MS/MS
⦁ HPLC
⦁ LC–MS
⦁ LC–MS/MS
Markets Served At Horizon Technology, our goal is to improve sample prepa-
ration for every conceivable application and industry. Our
systems are versatile enough to process almost any sample
matrix and volume. Building upon our success in environ-
mental and oil and grease applications, we have expanded
our technology and methods so the benefits of automated
Horizon Technology, part of Biotage
16 Northwestern Drive
Salem, NH 03079
T E L E P H O N E
(603) 893-3663
F A X
(603) 893-4994
E - M A I L
W E B S I T E
www.horizontechinc.com
N U M B E R O F E M P L O Y E E S
35
Y E A R F O U N D E D
1992
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 25www.chromatographyonline.com
Major Products/Services Below is a sample of some HPLC column
phases from Imtakt:
⦁ Dacapo DX-C18: 2.5 μm particle C18 col-
umn designed with a revolutionary dual
matrix particle technology, optimized for
extreme pH conditions.
⦁ Intrada Amino Acid: The world’s first
mixed-mode column designed to sepa-
rate amino acids without the need for any
derivatization.
⦁ Intrada SEC: Silica based SEC column
designed for use in SEC-MS compatible
conditions. GPC and GFC.
⦁ SCHERZO SM-C18: C18 multi-mode
column with both anion and cation
exchange.
⦁ PRESTO FF-C18: Consists of C18 bonded
to monodispersed 2 μm non-porous
silica. It is useful for both biopolymer and
synthetic polymer separations. Ideal for
intact antibody and ADC analysis.
⦁ CADENZA CD-C18: High resolution; 25–
50% lower pressure; best with hydropho-
bic compounds, molecular recognition,
and small molecule isomer separation.
⦁ Cadenza HS-C18: High resolution C18
column designed to accept direct injec-
tion of biological samples. No need to
protein precipitate your samples for high
throughput early drug discovery or clinical
lab testing.
⦁ UNISON UK-AMINO: Revolutionary aque-
ous durability for aminopropyl phase;
aqueous to non-aqueous normal phase
separation.
Facility We are located in Portland, Oregon, and
deliver next day for 95% of North Ameri-
can orders and always within one week.
Imtakt USA
Company Description Our HPLC columns have been designed and manufactured
by Imtakt Corporation with exceptional craftsmanship and
decades of industry experience. Truly some of the most unique
column chemistries in the market today, our columns give
chromatographers:
⦁ High resolution
⦁ 25–50% lower pressure
⦁ Novel chemistry.
Chief Chromatographic Techniques Supported⦁ High performance liquid chromatography
⦁ Ultrahigh-pressure liquid chromatography
⦁ Liquid chromatography–mass spectrometry
⦁ Reversed phase
⦁ Normal phase
⦁ Anion exchange
⦁ Cation exchange
⦁ Multi-mode
⦁ Small-molecule separations
⦁ Protein separations
Markets Served All LC and LC–MS markets including: pharmaceutical, biotech,
contract research, forensic, clinical diagnostic, food and
beverage, industrial, chemical, environmental, and academic
research.
Imtakt USA2892 NW Upshur St. Suite A
Portland, OR 97210
T E L E P H O N E
(215) 665-8902
Toll Free:
(888) 456-HPLC
F A X
(501) 646-3497
E - M A I L
W E B S I T E
www.imtaktusa.com
Y E A R F O U N D E D
2003
26 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
and quantify both target and unknown
analytes, dramatically reducing overall
analysis times and increasing productivity.
Products include:
⦁ Pegasus BT® GC–TOFMS: The tried-
and-tested reliability and durability
of our Pegasus brand in a convenient
benchtop unit
⦁ Pegasus BT 4D GCxGC–TOFMS: Four
dimensions of analytical resolution offer
a more complete analysis in a benchtop
instrument
⦁ Pegasus GC-HRT+: GCMS with industry-
leading resolution (up to 50,000) and
mass accuracy for high-information
content analysis
⦁ Pegasus GC-HRT+ 4D: Combining
the highest performance GCxGC
and TOFMS on the market with High
Resolution Deconvolution®(HRD®)
Facility LECO’s global headquarters in St. Joseph, Michi-
gan, include the Elizabeth S. Warren Technical
Centre, a 28,000 square-foot facility exclusively
dedicated to the research and development of
innovative instrumentation and equipment for
LECO’s separation science line. Customer train-
ing demonstrations and application support
are available at our Life Science and Chemical
Analysis Centre in St. Joseph. LECO has more
than 25 subsidiaries worldwide, plus additional
international distributors.
LECO Corporation
Company Description For over 80 years, industries around the world have trusted LECO
to deliver technologically advanced products and solutions. Today’s
technologies for separation science reflect LECO’s commitment to
understanding your lab’s challenges and providing solutions that can
investigate highly complex samples while streamlining your analysis.
LECO instruments offer unparalleled separation, accuracy, resolving
power, deconvolution, and speed to increase your lab’s productivity
using GC–TOFMS, GCxGC, GCxGC–TOFMS, and high-resolution GC–
and GCxGC–TOFMS. For more information, please visit them on the
web at www.leco.com.
Chief Chromatographic Techniques Supported ⦁ GC–TOFMS
⦁ High Resolution GC–TOFMS
⦁ GCxGC–FID/ECD
⦁ GCxGC–TOFMS
⦁ High Resolution GCxGC–TOFMS
Markets Served LECO Separation Science instruments are used in a variety
of applications, helping users to uncover unidentified
compounds in their samples. Markets include metabolomics,
consumer product safety, food, flavor, fragrance,
environmental, and energy and fuels analysis.
Major Products/Services An ideal choice for laboratories investigating highly complex
samples, LECO products feature exclusive ChromaTOF brand
software with all the tools needed to easily locate, identify,
LECO Corporation3000 Lakeview Avenue
St. Joseph, MI 49085
T E L E P H O N E
(800) 292-6141
(269) 985-5496
F A X
(269) 982-8987
E - M A I L
W E B S I T E
www.leco.com
N U M B E R O F E M P L O Y E E S
717
Y E A R F O U N D E D
1936
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 27www.chromatographyonline.com
Major Products/Services LGC Standards has a network of dedicated
sales offices extending across 20 countries
in 5 continents and more than 30 years of
experience in the distribution of reference
materials. These products and services are
essential for accurate analytical measure-
ment and quality controls, ensuring sound
decisions are made based on reliable data.
We work with customers to achieve
excellence in investigative, diagnostic, and
measurement science across a wide vari-
ety of sectors including pharmaceuticals,
forensics, clinical, biotechnology, food,
agriculture, environmental testing, indus-
trial petrochemicals, packaging, academia,
security, and sports supplements.
Facility We have an unparalleled breadth of ISO
accredited reference material facilities at 4
sites across the UK, the US and Germany.
Our North American headquarters is based
in Manchester, NH.
LGC Standards
Company Description LGC Standards is a global manufacturer and distributor
with a portfolio of more than 100,000 certified reference
materials, standards, and proficiency testing products for the
pharmaceutical, environmental, food & beverage, forensics,
clinical and industrial market sectors. Our ISO accreditations
include: ISO 9001:2015, ISO 17034/ISO Guide 34, GMP/
GLP, ISO 13485, ISO/IEC 17025, ISO/IEC 17065 and ISO/IEC
17043.
As the UK’s designated NMI (National Measurement
Institute) for chemical and bio-measurement, LGC works in
partnership with governments, intermediaries and private sector
organizations to address the measurement needs of key sectors
including healthcare, food, environmental, security and energy.
Chief Chromatographic Techniques Supported⦁ All Gas Chromatography
⦁ Liquid Chromatography
⦁ Ion Chromatography
Markets Served Food & Beverage, Environmental, Pharmaceutical, Forensic,
Clinical, Industrial, Life Science, Petrochemical, Cannabis,
Governmental, Academic, Security, Sports, Energy,
Biotechnology, Agriculture
LGC Standards276 Abby Road,
Manchester, NH 03103
T E L E P H O N E
(603) 622 7660
F A X
(603) 622 5180
E - M A I L
W E B S I T E
lgcstandards.com
N U M B E R O F E M P L O Y E E S
US: 700
Elsewhere: 2000
Y E A R F O U N D E D
1842
28 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
MACHEREY-NAGEL GmbH & Co. KG
Neumann-Neander-Str. 6-8,
52355 Düren, Germany
MACHEREY-NAGEL Inc.
2850 Emrick Blvd.,
Bethlehem, PA 18020, USA
W E B S I T E
www.mn-net.com
N U M B E R O F E M P L O Y E E S
ca. 650
Y E A R F O U N D E D
1911
Major Products/Services NUCLEOSIL®, one of the first spherical silica
gels in the 1970s, is still packed in stainless
steel columns by MN. These columns with
various C18
modifications are validated in
many drug testing methods. In recent years,
new highly pure and ultra-spherical HPLC
and UHPLC silica gels followed.
Today the column range of totally
porous NUCLEODUR® and fused-core
NUCLEOSHELL® comprise more than 25
stationary phases–-including a new core-shell
biphenyl phase with enhanced retention for
aromatic and unsaturated substances.
More information: www.mn-net.com/HPLC
MACHEREY-NAGEL, a pioneer in thin-
layer chromatography is manufacturing
glass plates as well as aluminum and plastic
sheets coated with silica gels and other sor-
bents for TLC and HPTLC. The latest develop-
ments SIL HD and Nano-SIL HD glass plates
are characterized by outstanding dyeability,
good wettability, and abrasion resistance due
to an optimized binder system.
More information: www.mn-net.com/TLC
Classical CHROMABOND® silica gel
phases with various modifications (for ex-
ample, C18
, C8, NH
2, OH, CN) and modern
polymeric resins are widely used for sample
preparation in environmental analysis, food
safety control, or clinical applications. The
hydrophilic-lipophilic balanced polymeric
SPE adsorbent CHROMABOND® HLB and
the CHROMABOND® HR-Xpert line of poly-
styrene-divinyl based reversed-phase and
mixed-mode ion-exchange resins offers a full
toolbox of innovative SPE products.
More information: www.mn-net.com/SPE
Facility The headquarters in Germany and
branches in the United States, Switzerland,
and France, as well as a globally operating
network of distributors in more than 150
countries, ensures worldwide availability
of MN products and services.
MACHEREY-NAGEL
Company Description Since 1911, MACHEREY-NAGEL represents high quality, innova-
tion, and reliability in analytical chemistry and life science. As one
of today’s leading manufacturers, MACHEREY-NAGEL offers a
broad range of products for chromatography, filtration, rapid tests,
water analysis and bioanalysis.
MN´s expertise in manufacturing of chromatography media
is based on many years of experience in silica technology. The
development of the spherical HPLC silica NUCLEOSIL® and the
introduction of commercially available ready-to-use TLC plates
and sheets are just two milestones emphasizing the pioneering
tasks of MN in promoting these separation techniques.
Chief Chromatographic Techniques Supported ⦁ SPE and Flash Chromatography
⦁ HPLC
⦁ TLC
⦁ GC
⦁ Chromatographic accessories (such as syringe filters, vials,
and caps)
Markets Served MN serves laboratories all over the world with HPLC, GC, and
SPE columns, TLC plates and sheets, and syringe filters as well as
suitable vials and caps. Customers from many different industries
(e.g., the food and beverage industry, pharmaceutical industry
and healthcare, chemical industry, institutes for environmental
analysis, biotechnology, universities and research institutes)
benefit from optimal and reliable solutions for analytical tasks in
method development and routine analysis.
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 29www.chromatographyonline.com
introduced many highly successful products
to the analytical laboratory:
⦁ UNITY-xr: A universal thermal desorption
unit for sorbent sampling tubes
⦁ TD100-xr: A fully automated TD system
for sorbent tubes
⦁ ULTRA-xr TD autosampler
⦁ CIA Advantage-xr systems for automated
cryogen-free analysis of air and gas sam-
pled using canisters
⦁ TT24-7 for continuous on-line monitoring
⦁ The Micro-Chamber/Thermal Extractor for
fast sampling of emissions from products
and materials
⦁ Wide range of accessories and consum-
ables for TD
⦁ Centri – A multi-technique sample pre-
concentration and injection platform, de-
livering enhanced analytical sensitivity and
higher throughput.
Markes also manufactures the BenchTOF
range of time-of-flight mass spectrometers
and associated software. Markes’s
technological innovation for mass
spectrometry also includes Select-eV®,
ground-breaking ion-source technology for
BenchTOF.
Facility Markes International’s factory, technical
center, and headquarters are located near
Cardiff, UK. The company also has technical
centers in Germany, USA and China. It
also supports a global distributor network.
Markes is a company of the Schauenburg
International Group.
Markes International
Company Description Markes International, an industry leader in technology
for trace organic analysis, manufactures a range of
instrumentation and software that enhances the analytical
capability and productivity of GC–MS systems.
Chief Chromatographic Techniques Supported ⦁ Thermal desorption (TD) as a sample concentration and
introduction technique for GC
⦁ Automated sample preparation and concentration (head-
space, headspace-trap, SPME, SPME-trap and high capacity
sorbent extraction)
⦁ Time-of-flight mass spectrometry (TOF-MS) for GC and GC×GC
⦁ GC–MS data reprocessing software
Markets Served ⦁ Defense/Homeland security
⦁ Environmental
⦁ Food and fragrance
⦁ Forensic and toxicology
⦁ Metabolomics
⦁ Petrochemical
Markes’s global customer base includes major industry,
government agencies, academia, and the contract service
laboratory sector.
Major Products/Services Markes is globally recognized for its innovation, high-quality
products, unrivalled technical expertise, and high level of
customer service within the field of analytical TD. As a global
technology leader of thermal desorption for GC, Markes has
Markes International Ltd. Gwaun Elai
Medi-Science Campus,
Llantrisant, RCT, CF72 8XL, UK
Markes International GmbH
Bieberer Straße 1–7, 63065
Offenbach am Main, Germany
Markes International, Inc.
2355 Gold Meadow Way,
Gold River, CA 95670, USA
Markes Instruments (Shanghai)
Co., Ltd No. 1 Building, No. 7
Guiqing Road, Xuhui District,
Shanghai 200233 P.R. China
TELEPHONE
+44 (0)1443 230 935 (UK)
+49 (0)69 6681089-10 (Germany)
+1 866 483 5684 (toll-free) (USA)
+86 21 5465 1216 (China)
NUMBER OF EMPLOYEES: 140
YEAR FOUNDED: 1997
30 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services Our Milli-Q® Lab Water purification system
portfolio offers a broad range of pure and
ultrapure water purification systems and
services designed for scientists working
in both validated and non-validated
environments.
Facility The Life Science business of Merck KGaA,
Darmstadt, Germany, which operates as
MilliporeSigma in the U.S. and Canada,
has 60 manufacturing sites worldwide.
MilliporeSigma, the vibrant M and
Milli-Q are trademarks of Merck KGaA,
Darmstadt, Germany or its affiliates.
All other trademarks are the property
of their respective owners. Detailed
information on trademarks is available
via publicly accessible resources.
MilliporeSigma
Company Description The Life Science business of Merck KGaA, Darmstadt,
Germany, which operates as MilliporeSigma in the U.S. and
Canada, has 20,000 employees, with a portfolio of more than
300,000 products enabling scientific discovery. Udit Batra is
the global chief executive officer of MilliporeSigma.
Merck KGaA, Darmstadt, Germany completed its $17 billion
acquisition of Sigma-Aldrich in November 2015, creating a
leader in the $125 billion global life science industry.
Merck KGaA, Darmstadt, Germany is a leading company for
innovative and top-quality high-tech products.
Chief Chromatographic Techniques Supported ⦁ Analytical HPLC
⦁ Gas Chromatography
⦁ Ion Chromatography
⦁ TLC and HPTLC
⦁ Mobile Phases for Chromatography
Markets Served ⦁ Pharmaceutical
⦁ Clinical
⦁ Academic
⦁ Industrial
⦁ Research
⦁ Government Laboratories
MilliporeSigma400 Summit Drive,
Burlington, MA 01803
T E L E P H O N E
+1 (800) 645-5476
E - M A I L
W E B S I T E
www.emdmillipore.com
N U M B E R O F E M P L O Y E E S
20,000
Y E A R F O U N D E D
1668
Feel good in your method development?
Feel Better with UsTrust our analytical products in every stage of your drug
product development. Whether you’re working on bioanalytical
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SigmaAldrich.com/feel-better
The life science business of Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in the U.S. and Canada.
j������0HUFN�.*D$��'DUPVWDGW��*HUPDQ\�DQG�RU�LWV�DɡOLDWHV��$OO�5LJKWV�5HVHUYHG��0LOOLSRUH6LJPD�DQG�WKH�YLEUDQW�0�DUH�WUDGHPDUNV�RI�0HUFN�.*D$��'DUPVWDGW��*HUPDQ\�RU�LWV�DɡOLDWHV��$OO�RWKHU�WUDGHPDUNV�DUH�WKH�SURSHUW\�RI�WKHLU�UHVSHFWLYH�RZQHUV��'HWDLOHG�LQIRUPDWLRQ�RQ�WUDGHPDUNV�LV�DYDLODEOH�YLD�SXEOLFO\�DFFHVVLEOH�UHVRXUFHV����
2018-14251
32 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
cal sciences, in addition to pharmaceutical,
environmental, and petrochemical analysis,
genomics, proteomics, neurology, clinical in-
strumentation, and a wide variety of related
technologies. Typical applications include re-
search, process monitoring and control, qual-
ity monitoring and control, forensics, package
leak testing, drug delivery, and DNA fragment
analysis (HID), in addition to unique applica-
tions requiring precision drawn capillary.
Major Products/Services Advances in chromatography research and
analysis have been aided by proprietary
improvements to the properties of Molex
synthetic fused capillary tubing and
techniques for handling, cutting, cleaving,
and laser machining. Molex manufactures
Polymicro high-strength, high-temperature,
flexible fused silica capillary tubing; square
capillary tubing; windowed capillary tubes;
UV transparent coating; precision cleaved-
to-length tubing; multi-lumen tubing;
multimode, step-index fused silica optical
fiber with polyimide, silicone, acrylate and
fluoropolymer buffers; solarization resistant
optical fiber for deep UV; broad spectrum
fiber; IR waveguides; fiber optic cables and
assemblies; silica and quartz base materials;
and micro-components including laser
machined fiber tips, telecommunications
ferrules and sleeves and Inner Lok™ unions
and Y-splitters for GC. New innovations
include VS Tight-Tolerance capillary, nano-
Capillary, and fiber bundles.
Facility Polymicro products are manufactured at
Molex’s facility located in Phoenix, Arizona.
The state-of-the art facility is ISO 9001,
13485, and 14001 certified and features
a glass laboratory, multiple draw towers,
sophisticated testing and laser machining
capabilities. We offer large and custom
orders, in addition to select, pre-packaged
Polymicro capillary tubing and optical fibers
for smaller orders. Please contact us at
[email protected] to initiate a
quote or request a copy of the Polymicro
solution handbook.
Molex
Company Description As a global leader in capillary tubing and specialty optical fiber
products for chromatography, Molex designs and manufactures
a large portion of Polymicro capillary tubing and multimode
step-index fibers used throughout the world. The company’s
extensive portfolio of products serves applications such as
aerospace, military and defense, analytical, astronomy, automo-
tive, biotechnology, communications, energy, manufacturing,
medical, pharmaceutical, and telecommunications.
Molex solves complex optical challenges for the world’s innova-
tors by anticipating and delivering what our customers need most.
From a globally integrated approach to seamless collaboration, we
bring expertise and innovation together to help bring your product
vision to reality. Our team works closely with yours to deliver the
results for your specific application needs by leveraging our heri-
tage of innovation, industry expertise and superior quality.
Chief Chromatographic Techniques Supported ⦁ Capillary Electrophoresis, CE
⦁ Cytometry
⦁ Gas Chromatography, GC
⦁ High Pressure Liquid Chromatography, HPLC
⦁ Lab-on-a-chip
⦁ Liquid Chromatography, LC
⦁ nano-Liquid Chromatography, nano-LC
⦁ Spectroscopy, Ultra Violet to Mid-Range Infrared
Markets ServedMolex capillary tubing, optical fibers, fiber optic assemblies, fiber
and tubing arrays, and bundles are commonly used in the analyti-
Molex 18019 N 25th Ave.,
Phoenix, AZ 85023
T E L E P H O N E
(602) 375-4100
F A X
(630) 813-9995
W E B S I T E
www.molex.com/polymicro
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 33www.chromatographyonline.com
Neta Scientific Inc.4206 Sylon Blvd.,
Hainesport, NJ 08036
T E L E P H O N E
(800) 343-6015
F A X
(609) 265-8213
E - M A I L
W E B S I T E
www.netascientific.com
N U M B E R O F E M P L O Y E E S
40+
Y E A R F O U N D E D
1999
Neta Scientific Inc.
We also offer an integrated program called
Laboratory Equipment Asset Procurement
Services (LEAPS) that provides new and
existing customers within the global
science market with convenient access
to end-to-end laboratory services and
insights. It combines OEM contract
administration, parts and relocation
services, and reporting with tier 1
diversity spend and cost savings to drive
operational efficiencies and economic
outcomes nationwide.
Markets Served Neta Scientific serves research and
development labs throughout North
America, encompassing the pharmaceutical,
biotech, life sciences, academia and research
institutions, government facilities, food and
flavors, industrial testing, and chemical
industries.
Facility The corporate offices and main warehouse
are headquartered in Hainesport, New
Jersey. We also maintain additional
representation throughout the United States.
Company DescriptionNeta Scientific is a laboratory supplies and services company that
enables the global science and clinical market to more effectively
conduct world-leading research and development. We centralize
superior supplies, services, and supply chain management with
a customer-centric approach, innovative technologies and diver-
sity certifications for customers to easily gain access to the tools
needed to improve global health and safety and meet corporate
objectives.
Major Products/ServicesAt Neta Scientific, we enable your mission by centralizing
superior laboratory supplies and supply chain management
with our unique ability to provide pass-through support
for major brand suppliers, as well as OEM contract, parts,
consumables, and services to give you back the time you
need.
⦁ Chromatography
⦁ Life Sciences
⦁ Labware
⦁ Chemicals & Reagents
⦁ Services (LEAPS)
⦁ Small & Large Bench Instruments
⦁ Cold Storage
34 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services OI Analytical provides instruments that
enhance chromatographic separations and
analysis including:
⦁ Custom-configured, integrated GC and
GC–MS systems
⦁ Purge and trap sample concentrators
⦁ Water and soil autosamplers for VOC
analysis
⦁ Selective GC detectors including unique
tandem combinations
⦁ PFPD–pulsed flame photometric detector
⦁ XSD™ Halogen specific detector
⦁ PID/ELCD tandem photoionization/
electrolytic conductivity detector
⦁ PID/FID tandem photoionization/
flame-ionization detector
⦁ PID/XSD tandem photoionization/
halogen specific detector
⦁ Automated chemistry analyzers
Facilities OI Analytical operates research and
manufacturing sites in College Station,
Texas, and Birmingham, Alabama,
occupying 88,000 square feet.
OI Analytical
Company Description OI Analytical designs and manufactures instrumentation for
chemical analysis. Data from our analytical instruments serve
as the basis for informed decisions affecting human health
and safety, environmental protection, industrial operations,
and product quality.
Chief Chromatographic Techniques Supported ⦁ GC
⦁ GC–MS
⦁ Purge-and-trap sample introduction
Markets Served Principal markets/industries served include environmental
testing, drinking and wastewater treatment, chemicals and
petrochemicals, pharmaceuticals, food and beverage,
homeland security, and chemical weapons demilitarization.
OI Analytical151 Graham Road
P.O. Box 9010
College Station, TX 77842
T E L E P H O N E
(979) 690–1711
(800) 653–1711
F A X
(979) 690–0440
E - M A I L
W E B S I T E
www.oico.com
N U M B E R O F E M P L O Y E E S
121
Y E A R F O U N D E D
1969
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 35www.chromatographyonline.com
Chief Chromatographic Techniques Supported ⦁ GC–FID, FPD, NPD
⦁ GC–HALL, ECD, TCD, HST-Wire
⦁ Capillary separations
⦁ Packed separations
Markets Served ⦁ Agriculture
⦁ Biotechnology
⦁ Chemicals
⦁ Chemical and explosives detection
⦁ Energy
⦁ Environmental
⦁ Inorganic chemicals
⦁ Instrument development
⦁ Life science
⦁ Organic chemicals
⦁ Paints and coatings
⦁ Petrochemicals
⦁ Pharmaceuticals
⦁ Plastics
Major Products/Services Gas generators for the following analytical
instruments:
⦁ Gas chromatographs
⦁ LC–MS
⦁ FT-IR spectrometers
⦁ ICP emission spectrometers
⦁ TOC analyzers
⦁ Atomic absorption spectrophotometers
⦁ Nuclear magnetic resonance (NMR)
⦁ Rheometers/thermal analyzers
⦁ Sample evaporators/concentrators
Facilities Parker Hannifin manufactures all gas genera-
tors in Haverhill, Massachusetts. Parker has
over 50,000 generators installed globally and
distribution points worldwide.
Parker Hannifin
Company Description Safety: Parker Balston gas generators completely eliminate the
safety hazards involved with handling high-pressure gas cylinders.
Enjoy hassle-free automation with no tanks to charge and no
downtime.
Reliability: Thousands of laboratories worldwide have
Parker Balston gas generators in routine use. Parker Balston
gas generators are recommended and used by major instru-
ment manufacturers. We offer the best technology at an af-
fordable price from the brand you trust.
Quality: Each Parker Balston gas generator is manufactured
under a strict total quality management program. We have a
world-class ISO 9001-certified manufacturing facility in the
United States. All Parker Balston gas generators are backed
by a complete satisfaction guarantee. Parker offers preventa-
tive maintenance, extended warranties, and field repair pro-
grams for all laboratory gas generators, as well as a network
of highly specialized sales, application, and technical support
people.
Products: Hydrogen gas generators produce 99.99999%
pure hydrogen for gas chromatographs. Zero air genera-
tors produce zero grade air for gas chromatographs. UHP
nitrogen generators produce 99.9999% pure nitrogen for
GCs or ICP spectrometers. FT-IR gas generators produce
dry, CO2-free purge gas for FT-IR spectrometers. Pure
air and nitrogen generators produce dry, ultrapure com-
pressed gas for laboratory instruments, including LC–MS
instruments.
Parker Hannifin Corporation
Industrial Gas Filtration and Generation Division
4087 Walden Avenue
Lancaster, NY 14086
T E L E P H O N E
(978) 858-0505
F A X
(978) 556-7501
W E B S I T E
www.labgasgenerators.com
N U M B E R O F E M P L O Y E E S
55,000
Y E A R F O U N D E D
1924
36 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services PerkinElmer, Inc. offers a wide range of
instrumentation and solutions to meet
your analytical testing needs:
⦁ Atomic spectroscopy: AA, ICP-OES,
ICP-MS
⦁ Chromatography: GC and GC custom
solutions, GC–MS, HPLC and UHPLC,
LC–MS
⦁ Hyphenated techniques: HPLC–ICP-MS,
GC–ICP-MS, HS-GC, HS-GC–MS, TD-GC,
TD-GC–MS, TG-IR, TG-MS, TG-GC–MS
⦁ Mass spectrometry: ICP-MS, GC–MS,
LC–MS and LC–MS/MS
⦁ Molecular spectroscopy: FT-IR and
FT-NIR, UV-vis and UV-vis-NIR,
fluorescence spectroscopy
⦁ Thermal analysis: DSC, TGA, STA, DMA
⦁ Organic elemental analysis: CHN/O,
CHNS/O
⦁ Consumables: atomic spectroscopy,
chromatography, mass spectrometry,
molecular spectroscopy, thermal
analysis, elemental analysis
⦁ OneSource® Laboratory Services
Facility PerkinElmer, Inc. operates globally in 150
countries.
PerkinElmer, Inc.
Company Description PerkinElmer, Inc. is a global leader committed to innovating
for a healthier world. Our dedicated team of employees is
passionate about providing customers with an unmatched
experience as they help solve critical issues especially
impacting the diagnostics and discovery and analytical
solutions markets. Our innovative detection, imaging,
informatics, and service capabilities, combined with deep
market knowledge and expertise, help customers gain earlier
and more accurate insights.
Chief Chromatographic Techniques Supported⦁ Gas chromatography
⦁ GC–MS and portable GC–MS
⦁ Liquid chromatography—HPLC and UHPLC
⦁ Headspace and thermal desorption sample handling
⦁ LC–MS and LC–MS/MS
Markets Served Our solutions in the areas of diagnostics, life sciences,
and applied markets help scientists, lab professionals,
and clinicians answer important questions needed to help
customers gain earlier and more accurate insights to
improve lives and the world around us.
PerkinElmer, Inc.940 Winter Street
Waltham, MA 02451
T E L E P H O N E
(781) 663-6900
E - M A I L
CustomerCareUS@
perkinelmer.com
W E B S I T E
www.perkinelmer.com
N U M B E R O F E M P L O Y E E S
11,000
Y E A R F O U N D E D
1937
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 37www.chromatographyonline.com
Peak Scientific
Company Description With over two decades in pioneering reliable gas generator
technology, Peak Scientific develops market-leading
nitrogen, hydrogen, and zero air systems mainly for the
fields of LC–MS and GC.
An on-site gas generator from Peak Scientific is the
practical and cost-effective alternative to pressurized
cylinders.
Our forte is in providing our customers with unrivaled
peace of mind and hassle free gas generation solutions
for their specific laboratory demands, backed up by our
world-class technical support and ongoing service care
throughout the generator’s lifespan. With a rapid response
and offices on every continent we deliver a local service
on a global scale.
Chief Chromatographic Techniques Supported ⦁ LC–MS
⦁ GC
Markets Served ⦁ Laboratory
Major Products/Services ⦁ Nitrogen Generators
⦁ Hydrogen Generators
⦁ Zero Air Generators
Peak ScientificFountain Crescent
Inchinnan Business Park
Inchinnan
PA4 9RE
Scotland, UK
T E L E P H O N E
+1-866-647-1649
F A X
+1-978-608-9503
E - M A I L
W E B S I T E
www.peakscientific.com
N U M B E R O F E M P L O Y E E S
USA: 50+
Elsewhere: 400+
Y E A R F O U N D E D
1997
38 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
For fast and easy clean-up and
enrichment of peptide samples prior
to injection, we will launch a trapping
column soon, designed for optimal
compatibility with PharmaFluidics’ μPAC™
reversed-phase analytical C18 nano-LC
columns.
Facility PharmaFluidics’ headquarters are located
at the Tech Lane Ghent Science Park
(Campus A) in Ghent (Belgium), a vibrant
ecosystem of international corporate R&D
centers, public research institutes and
high-tech growth enterprises. International
commercialization of the PharmaFluidics’
products is organized by either a direct
sales team in Europe or by indirect sales
channels the US and the rest of the world.
PharmaFluidics
Company Description Introducing micro-chip manufacturing technology in analytical
chromatography, PharmaFluidics uses a lithographic
etching process to create a perfectly ordered separation
bed on a silicon chip. PharmaFluidics wants to bring liquid
chromatography to a next level of efficiency in all aspects,
by providing separation devices with an unprecedented
reproducibility and robustness, in a format that enables
extreme user-friendliness and resolution, and opens the way
to further miniaturization and integration.
Chief Chromatographic Techniques Supported ⦁ Nano LC-MS
Markets Served The μPAC™ micro-Chip based chromatography columns
are commercially available for proteomic, lipidomic, and
metabolomic profiling, with specific applications in bio-
marker, diagnostics and drug research & development.
μPAC™ also enables a very detailed characterization of
biopharmaceuticals and biosimilars, detecting amino acid
substitutions and post-translational modifications.
Major Products/Services To serve your custom separation needs, μPAC™ columns
are available in various lengths (50–200 cm) and equipped
with connectors matching your application. Stationary phase
chemistry is currently focusing on reversed phase HPLC
separations for applications in metabolomics, proteomics and
lipidomics.
PharmaFluidicsTechnologiepark-Zwijnaarde 82
B9052 Ghent (Zwijnaarde)
Belgium
E - M A I L
W E B S I T E
www.pharmafluidics.com
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 39www.chromatographyonline.com
Markets Served Mass spectrometry, nuclear detection,
medical instrumentation, pharmaceutical
safety, industrial instrumentation, and image
intensification, as well as the custom design
and manufacture of detectors, sensors, and
ion mobility analyzers.
Major Products/Services Photonis offers a complete range of high
performance scientific and medical detector
products. Our market includes electron
multipliers, microchannel plates, mass
spectrometry fiber optics and resistive
glass, advance performance time-of-flight
detectors, image intensifiers, ion mobility
analyzers, neutron imagers, and other related
products. Our detection products are found
in most of today’s technology-based markets,
including analytical instrumentation, medical
diagnostics, chemistry, drug discovery,
high-energy physics, space exploration, and
scientific research. Photonis is the largest
supplier of standard, retrofit, and custom
detectors in the mass spectrometry, residual
gas analyzer, and electron microscope
markets providing advanced detector designs
for the highest sensitivity through superior
signal collection and noise reduction.
Facilities Sturbridge, MA; Lancaster, PA; Brive,
France; Roden, Netherlands
Photonis Scientific, Inc.
Company Description Photonis is a multinational high-technology group, with more than
40 years of experience in manufacturing, sales, and innovation,
specializing in charged particle and photon sensor technology.
The group operates internationally in the night vision, industrial,
scientific, and medical markets.
Chief Chromatographic Techniques Supported ⦁ Liquid chromatography detectors
⦁ Ion mobility spectrometry
⦁ Mass spectrometers
⦁ UV–vis fixed wavelength
⦁ UV–vis variable wavelength
⦁ Gas chromatography detectors and accessories
⦁ Detector accessories
⦁ Mass spectrometers: high-resolution
⦁ Mass spectrometers: low-resolution
⦁ Mass spectrometers, residual gas analysis, magnetic
⦁ Mass spectrometers, residual gas analysis, quadrupole
⦁ ICP-MS
⦁ Time-of-flight mass spectrometry
⦁ Other detectors and accessories
⦁ Supercritical fluid chromatography detectors and accessories
⦁ Radioactivity
⦁ Neutron imaging
Photonis Scientific660 Main Street
Sturbridge Business Park
Sturbridge, MA 01566
T E L E P H O N E
(508) 347-4000
F A X
(508) 347-3849
E - M A I L
W E B S I T E
www.photonis.com
N U M B E R O F E M P L O Y E E S
US: 150
Elsewhere: 900
Y E A R F O U N D E D
1937
40 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
PickeringLaboratories, Inc.
1280 Space Park Way
Mountain View, CA 94043
T E L E P H O N E
(800) 654-3330
(650) 694-6700
F A X
(650) 968-0749
E - M A I L
W E B S I T E
www.pickeringlabs.com
www.pickeringtestsolutions.com
N U M B E R O F E M P L O Y E E S
18
Y E A R F O U N D E D
1980
Pickering Laboratories, Inc.
Chief Chromatographic Techniques SupportedAnalysis methods include:
⦁ Glyphosate herbicide
⦁ Carbamate pesticides
⦁ Biogenic amines
⦁ Amino Acids analysis
⦁ Antioxidants
⦁ Polyether antibiotics
⦁ Mycotoxins
Markets Served Pickering Laboratories designs,
manufactures, and sells specialized
analytical instrumentation and chemistry
for the environmental, pharmaceutical,
food testing, clinical and cosmetics
industries, as well as biochemical
laboratory markets.
Additionally, Pickering Laboratories
provides testing solutions for consumer
product testing facilities, the textile
industry and electronics manufacturers
around the world.
An extensive network of distributors
represents Pickering Laboratories products
worldwide and can be found on our
webpage.
Facility Our Mountain View, California, headquar-
ters includes research and development,
manufacturing, technical support, training,
administration, and customer service.
Products are manufactured in
accordance with specified quality-control
guidance and a certificate of analysis is
provided for all chemistry products.
Company Description Pickering Laboratories, Inc. manufactures products for
both analytical laboratories and consumer product testing
laboratories.
Application-Specific Analytical ProductsOur analytical columns, high-purity reagents and post-column
derivatization instruments pair with any manufacturer’s HPLC
to enable specialized application analysis. Some of our more
popular applications include: Amino Acids, Carbamates,
Glyphosate, Aminoglycoside Antibiotics, Polyether Antibiotics,
Biogenic Amines, Aflatoxins and Paralytic Shellfish Toxins.
Analytical reagents and eluents are prepared according to
official AOAC, EPA and FDA methods.
Pickering’s post-column derivatization instruments connect
to virtually any HPLC and can be easily configured to detect a
wide range of compounds with high sensitivity and specificity.
Consumer Product Testing SolutionsPickering Laboratories’ artificial body fluids are made to
official product testing specifications from AATCC, ISO, DIN,
BS, EN and other worldwide standards organizations. They are
used for product development, quality testing, and research
applications.
Our analytical chemistry expertise and quality
manufacturing ensure outstanding batch reproducibility
and precise formulations. Custom formulations are also
routinely produced with the same guarantee of precision and
reproducibility. Please inquire with your request.
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 41www.chromatographyonline.com
⦁ Chemical manufacturing
⦁ Food analysis
⦁ Medical analysis
⦁ Pharmaceutical analysis
Major Products/Services Reference Materials
⦁ GPC/SEC standards and kits
⦁ Easy-to-use ReadyCal calibration kits
⦁ MALDI kits
⦁ Viscosity and light scattering validation kits
⦁ Certified reference materials
⦁ Deuterated polymers
⦁ Tailor-made polymers
High Resolution Columns
⦁ GPC/SEC columns for all organic
eluents and all aqueous eluents
⦁ For high and low molecular weight
synthetic and biopolymers
⦁ For micro GPC/SEC up to preparative
scale
⦁ HighSpeed columns for fast analysis
Instrumentation and Software
⦁ GPC/SEC systems and components
⦁ Light scattering detectors
⦁ Viscosity detectors
⦁ dn/dc instrumentation
⦁ WinGPC UniChrom software
⦁ PoroCheck software for inverse GPC/SEC
Contract analysis (including HT-GPC
and specialty solvents)
⦁ Contract analysis
⦁ Molar mass determination
⦁ Branching/structure information
⦁ Method development and transfer
⦁ Complete product deformulation
⦁ Consulting
GPC/SEC Academy and Support
⦁ Full services from installation to valida-
tion, operation, and repair
⦁ GPC/SEC and software training schools
⦁ GPC/SEC training in-house tailored to
customers’ requirements
⦁ NetCommunity with application and pub-
lication downloads
Facility PSS is located in Amherst, MA. Headquarters
are located in Mainz, Germany. PSS also has
offices in The Netherlands and works with a
network of distributor partners in most other
countries around the world.
PSS Polymer Standards Service Inc.
Company Description GPC/SEC/GFC, IPC and 2D are versatile techniques for charac-
terizing polymers, biopolymers, polysaccharides, and proteins
used to determine molecular weight, size, and architecture. PSS
is fully dedicated to the advancement of macromolecular liquid
chromatography by developing true solutions and providing com-
petent and personal support. Based on excellent products and
cutting-edge technology, PSS creates easy-to-use and powerful
solutions for QC and R&D. From a single molar mass reference
material, contract analysis, and consulting, to turn-key systems for
GPC/SEC multi-detection with light scattering, viscometry, mass
spectrometry, or fully compliant GPC/SEC for the pharmaceutical
industry: PSS offers products and services required for successful
macromolecular analysis with expert support by LC enthusiasts.
Chromatographic Techniques Supported ⦁ Size-exclusion chromatography (SEC)
⦁ Gel permeation chromatography (GPC)
⦁ Gel filtration chromatography (GFC)
⦁ High-Temperature GPC (HT-GPC)
⦁ GPC/SEC viscometry / light scattering / triple
⦁ GPC/SEC mass spectrometry
⦁ Two-dimensional chromatography
⦁ Interaction polymer chromatography (IPC)
Markets Served Fully featured PSS applications provide solutions for the
analysis of natural and synthetic macromolecules divided into
the following sections:
⦁ Biopharma
PSS Polymer Standards Service Inc.
160 Old Farm Road,
Amherst, MA 01002
T E L E P H O N E
(413) 835-0265
E - M A I L
W E B S I T E
www.pss-polymer.com
Y E A R F O U N D E D
1994
42 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Facilities EMEAI
Postnova Analytics GmbH
Max-Planck-Strasse 14
86899 Landsberg, Germany
Tel: +49 8191 985 688-0
Fax: +49 8191 985 688-99
UNITED KINGDOM
Postnova Analytics UK Ltd.
Unit 64, Malvern Hills Science Park,
Malvern, Worcestershire
WR14 3SZ, UK
Tel: +44 1684 585167
NORTH AMERICA
Postnova Analytics Inc.
230 South, 500 East, Suite 110
Salt Lake City, UT 84102, USA
Tel: +1 801 521-2004
Fax: +1 801 521-2884
Postnova Analytics Inc.
Company Description Postnova Analytics offers the worldwide unique FFF-Platform,
which is a range of different field-flow fractionation (FFF)
and light scattering systems (MALS) for advanced separation,
fractionation, and characterization of nanoparticles, proteins,
polymers, and bio-macromolecules. Postnova offers a truly
complete FFF-MALS product range, which is widely used for
applications in biopharmaceutical, nanotechnology, environ-
mental, food, cosmetics, and polymer science. The Postnova
FFF-Platform can also be ideally coupled to dynamic light scat-
tering (Malvern Zetasizer Nano DLS) and inductively coupled
plasma–mass spectrometry (Agilent Technologies ICP-MS),
which provides high resolution size and molar mass separa-
tions as well as characterization and element speciation.
Chief Chromatographic Techniques Supported⦁ Field-flow fractionation (FFF)
⦁ Asymmetric FFF
⦁ Thermal FFF
⦁ Centrifugal FFF
⦁ Multi-angle light scattering (MALS)
Postnova Analytics Inc.230 South, 500 East, Suite 110
Salt Lake City, UT 84102
T E L E P H O N E
+1 (801) 521-2004
F A X
+1 (801) 521-2884
E - M A I L
W E B S I T E
www.postnova.com
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 43www.chromatographyonline.com
Power4, LLCPennsylvania Biotechnology Ctr.
3805 Old Easton Road,
Doylestown, PA 18902
T E L E P H O N E
(267) 614-4847
E - M A I L
W E B S I T E
www.power4llc.com
N U M B E R O F E M P L O Y E E S
USA: Team of Trusted Partners
Elsewhere: Team of
International Trusted
Partners
Y E A R F O U N D E D
2015
Power4, LLC
Major Products/Services Power4 offers an in-depth product
portfolio of power protection equipment
and clean effective power conditioning
solutions so that your analytical
equipment operates efficiently and free
from power issues.
Power4’s uninterruptible power supply
(UPS) solutions protect your electronic
equipment in the event of an outage.
Power4’s power conditioning solutions
protect your system from noise, spikes, and
transients that cause operational disruption
and degrade system components,
resulting in lost data, inaccurate test data,
communication errors, and “no trouble
found” service calls.
In addition, Power4 provides
specialized education, training, and
technical assistance along with the client-
specific tools and resources to ensure
long-term success.
Facility Power4 is located on the campus
of the Pennsylvania Biotechnology
Center of Bucks County in Doylestown,
Pennsylvania. The center seeks to advance
biotechnology in Bucks County and the
surrounding region, maximize synergies
between nonprofit scientists and their
commercial colleagues, and launch new
ideas and discoveries that will make a
difference.
Company Description Power4 understands there are many variables that determine
the success of an organization, business, or manufacturer. The
uninterrupted flow of clean, efficient power is one major variable
and vital for the performance of mission critical systems and
equipment. When downtime, service calls, hardware failures, and
inaccurate results threaten your customer experience and bottom
line, you need an innovative power quality strategy backed by
superior solutions, service, and support.
Experts at diagnosing, remedying, and preventing power
quality issues, Power4 is your prescription for success. Power4
can eliminate these issues to improve profitability and give you
the competitive advantage in your marketplace.
Chief Chromatographic Techniques SupportedAll techniques and system configurations
Markets Served Focusing on the Analytical Instrumentation industry, Power4
develops customized power protection solutions to meet the
specific power needs of critical systems in: Corporate and
University Research Laboratories; Biotechnology Centers;
Pharmaceutical Companies; Drug Development Companies;
Life Sciences Companies; and more.
Power4 creates and implements personalized power qual-
ity strategies for clean, uninterrupted power that improves
profitability and reduces downtime.
44 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services Proton OnSite offers hydrogen, nitrogen,
and zero air gas generators to fit the
needs of any laboratory. These units are
suited to provide ultra-high purity gas with
consistent and predictable results. Also,
Proton OnSite is the only provider of “Lab
Server” solutions, allowing large labs to
supply numerous mass spec instruments
from a single, central generator. Our line
of on-site gas generators is a simpler, less
expensive, and less complex approach to
supplying superior gas for laboratory and
scientific applications. These generators
are compact in size and available in
stackable configurations to maximize your
available lab space.
Proton OnSite
Company Description Proton OnSite, a wholly owned subsidiary of Nel ASA, Oslo,
Norway (OSE:NEL), manufactures hydrogen, nitrogen, and
zero air generators that you can rely on. Our advanced proton
exchange membrane (PEM) electrolysis systems, coupled
with uncompromising attention to excellence and quality,
enable us to deliver, install, and support gas generation
on every continent. No other company has as large of a
commercial fleet or as long of a history with reliability, as
Proton OnSite. Exclusively focused on customer solutions, we
have the experience and products to ensure success.
Markets Served ⦁ Environmental sciences
⦁ Food and beverage industries
⦁ Forensic sciences
⦁ Life sciences
⦁ Petrochemical industry
⦁ Pharmaceutical industry
Proton OnSite10 Technology Dr.
Wallingford, CT 06492
T E L E P H O N E
(203) 678-2300
F A X
(203) 949-8016
E - M A I L
W E B S I T E
www.protononsite.com
N U M B E R O F E M P L O Y E E S
100
Y E A R F O U N D E D
1996
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 45www.chromatographyonline.com
⦁ Industrial hygiene
⦁ Petrochemical
⦁ Pharmaceutical
Major Products/Services Plus 1 Service in everything we do. Living this
corporate core value every day ensures we
will surpass your expectations every time you
contact us! Our customer service team will
suggest time- and money-saving options and
is dedicated to getting your products to you
fast. Our technical service chemists can help
you from set-up to method development.
Visit our website where you can blog with
our chemists and review an extensive library
of technical publications, chromatograms,
product documentation, step-by-step guides,
interactive calculators, animations, and
educational material.
Restek’s commitment to continuous
innovation in chromatography sets us apart
from our competitors. We introduce and
stock hundreds of new products every year,
designed by chromatographers for
chromatographers.
⦁ Exceptional columns for UHPLC, HPLC,
LC–MS, GC, GC–MS, and GC×GC
⦁ Innovative accessories, instrument
replacement parts, and consumables
⦁ Air monitoring canisters and sampling
supplies
⦁ Sample prep products
⦁ Reference standards: stock and
custom-prepared formulations
⦁ Thousands of innovative products,
hundreds of chromatograms
Facilities Restek opened for business in 1985 in
a small business incubator in central
Pennsylvania. Today, more than 500
employee-owners work, play, and
celebrate milestones in a state-of-the-art
140,000-square-foot facility in Pennsylvania,
in our research facility in California, and in
our subsidiary locations in China, England,
France, Germany, Italy, and Japan.
Restek Corporation
Company DescriptionFor over 30 years, Restek has been a leader in developing
technologies and manufacturing products for gas and liquid
chromatography (GC and LC), including columns, reference
standards, sample preparation materials, accessories, and
more. We have decades of hands-on, practical experience
in chemistry, chromatography, and engineering, and our
reputation for going the extra mile with Plus 1 customer
service and top-performing products is well known
throughout the chromatography community. Restek is proud
to assist analysts around the world with monitoring the
quality and safety of air, water, soil, food, pharmaceuticals,
and petroleum. We proactively offer integrated solutions—
products, applications, and assistance—perfectly matched to
your needs, regardless of your industry. www.restek.com
Chief Chromatographic Techniques Supported ⦁ UHPLC
⦁ HPLC
⦁ LC–MS
⦁ GC
⦁ GC–MS
⦁ GC×GC
Markets Served ⦁ Air monitoring
⦁ Chemical
⦁ Clinical
⦁ Environmental
⦁ Food safety
⦁ Forensic
Restek Corporation110 Benner Circle
Bellefonte, PA 16823
T E L E P H O N E
(800) 356-1688
F A X
(814) 353-1309
E - M A I L
W E B S I T E
www.restek.com
N U M B E R O F E M P L O Y E E S
500
Y E A R F O U N D E D
1985
46 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services The wide range of products and tech-
niques offered by SepSolve includes the
company’s own INSIGHT™ flow modulator
and ChromSpace® software for GC×GC,
as well as sample preparation equipment,
robotic autosamplers, thermal desorbers,
and mass spectrometers from leading
global suppliers including CTC Analytics,
GL Sciences, and Markes International.
Facility SepSolve has offices and a demonstration
laboratory in Peterborough, UK, and
works closely with our partners to support
customers worldwide, with facilities in
countries including the US, Germany, and
China.
SepSolve Analytical Ltd
Company Description SepSolve Analytical is dedicated to helping analysts select
the best equipment for GC and GC×GC analysis of complex
mixtures. With many years of experience in the field and access
to a range of leading equipment suppliers, we’re very well-
placed to advise on the most difficult challenges in analytical
science—in everything from environmental monitoring to
petrochemical analysis and food aroma profiling.
Chief Chromatographic Techniques Supported ⦁ GC and GC×GC (and associated software)
⦁ TOF MS
⦁ FID
⦁ Sample preparation and concentration—Thermal desorption,
SPME and SPME–trap, High-capacity sorptive extraction,
Headspace and headspace–trap, Large-volume injection
Markets Served ⦁ Food and drink
⦁ Petrochemical
⦁ Fragrance
⦁ Environmental
⦁ Tobacco and e-cigarettes
⦁ Cannabis
SepSolve Analytical Ltd22 Commerce Road
Lynch Wood
Peterborough
PE2 6LR UK
T E L E P H O N E
UK: 44 (0)1733 669222
US: 1-888-379-3835
E - M A I L
W E B S I T E
www.sepsolve.com
N U M B E R O F E M P L O Y E E S
10
Y E A R F O U N D E D
2016
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 47www.chromatographyonline.com
Shodex/Showa Denko America, Inc.
420 Lexington Ave.
Suite #2335A
New York, NY 10170
T E L E P H O N E
(212) 370-0033
F A X
(212) 370-4566
E - M A I L
W E B S I T E
www.shodexhplc.com
Y E A R F O U N D E D
1973
Facility Showa Denko America, Inc., based in New
York, New York, provides technical and
sales support for Shodex HPLC columns
for customers and distributors in North
and South America. Our stock point in
New York allows for fast delivery in the
United States. Working with our laboratory
in Japan, we support customers’ analytical
needs.
TM
Shodex/Showa Denko America, Inc.
Company Description Shodex HPLC columns have been manufactured by Showa
Denko K.K. in Japan since 1973. Showa Denko K.K. is one of
Japan’s largest chemical companies. Our strength in polymer
synthesis led to the production of many unique and durable
polymer-based columns. The golden-mechanical fish is a
symbol of fast and smooth liquid chromatography analysis.
Chief Chromatographic Techniques SupportedHPLC column selection, method development, and trouble
shooting, as well as providing educational seminars
Markets Served ⦁ North America
⦁ South America
⦁ HPLC
⦁ Size exclusion
Major Products/Services Shodex carries thousands of different HPLC columns with
various separation modes. We are best known for high quality
size exclusion and saccharide analysis columns, as well as
unique polymer-based reversed and HILIC phase columns.
With additional selections of normal phase, ion exchange, ion
chromatography, high temperature, and multimode columns,
we are confident we can provide the most suitable column
for customers’ needs.
48 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Shimadzu Scientific Instruments
7102 Riverwood Drive
Columbia, MD 21046
T E L E P H O N E
(800) 477-1227
(410) 381-1227
F A X
(410) 381-1222
E - M A I L
W E B S I T E
www.ssi.shimadzu.com
N U M B E R O F E M P L O Y E E S
US: 480
Worldwide: 11,900
Y E A R F O U N D E D
Shimadzu Scientific
Instruments: 1975
Shimadzu Corporation: 1875
Shimadzu Scientific Instruments
Major Products/Services Shimadzu offers a wide range of advanced
UHPLC/HPLC, GC, and mass spectrometry
systems and components. Key systems
include:
⦁ Nexera X2 UHPLC—Offers unsurpassed
chromatographic efficiency, sensitivity,
resolution, and reliability.
⦁ Prominence UFLC/HPLC—Raises total
system productivity to new levels by
generating high-quality, reproducible
data without sacrificing performance,
reliability, or ruggedness.
⦁ i-Series Plus Integrated HPLC/UHPLC—
Providing the ultimate balance of high-
level performance and ease-of-use in
an integrated HPLC.
⦁ Nexera UC SFE-SFC—First fully auto-
mated system that combines on-line
SFE and SFC in a single flow path
⦁ LCMS-2020/8040/8045/8050/8060—
User-friendly single-quad and triple quad
LC–MS-MS systems deliver outstanding
speed, sensitivity, and reliability.
⦁ Q-TOF LCMS-9030—Allows users to ef-
fortlessly conduct critical qualitative and
quantitative analysis with genuine confi-
dence and ease.
⦁ Nexis GC-2030—Offers a modern ap-
proach to a classic chromatographic
technique, delivering exceptional perfor-
mance and faster ROI.
⦁ System GC—Fully applicated GC systems
based on industry-standard methods.
⦁ GCMS-QP2020/SE/TQ8040/TQ8050—
With Smart Technologies, single-quad and
triple-quad GC–MS/MS systems enable
new possibilities in sensitivity, durability,
performance, stability, and reliability.
Facilities Shimadzu’s US headquarters includes a cus-
tomer service and training center, a solution
center to showcase technologies, and an
innovation center for promoting collaborative
projects with customers. Shimadzu’s regional
facilities, strategically located around the US,
provide customers with local sales, service,
and technical support.
Company Description Shimadzu Scientific Instruments (SSI) is the North American
subsidiary of Shimadzu Corp., headquartered in Kyoto, Japan.
SSI was established in 1975 to provide analytical solutions
to a wide range of laboratories in the Americas. With a
vast installed base and preferred vendor status at many
institutions, SSI’s instruments are used by top researchers
across the globe, customers who can count on the stability,
experience, and support only Shimadzu offers.
Chief Chromatographic Techniques Supported ⦁ Ultrahigh-pressure LC
⦁ Ultra-fast LC
⦁ Analytical/prep HPLC
⦁ 2D LC
⦁ Online SFE-SFC
⦁ LC–MS/MS
⦁ Q-TOF LC–MS
⦁ GC
⦁ Comprehensive LC and GC
⦁ GC–MS/MS
Markets Served Shimadzu’s product line flexibility enables chromatographers in any
environment to select the instrument best suited to their application.
Shimadzu instruments are found in a wide range of labs, including
academic research, pharmaceutical, forensic, food and beverages,
petrochemical, life sciences, and environmental. Shimadzu provides
free technical support for the life of the instruments, and encourages
customer alliances to further product development.
Order consumables and accessories on-line at http://store.shimadzu.com Shimadzu Scientific Instruments Inc., 7102 Riverwood Dr., Columbia, MD 21046, USA
The Next Industry StandardGas Chromatograph
Nexis GC-2030, Shimadzu’s premier gas chromatograph, offers a modern approach to a classic
chromatographic technique. Designed with the user in mind, new innovative features, exceptional
performance and high-throughput capabilities will elevate your lab to the next level.
X Faster ROI with versatile, expandable configurations
X Reduced operating costs with Eco mode
X Improved workflow with touch-panel interface and remote communications
X Increased productivity with tool-free column installation and inlet maintenance
X Simplified operation with enhanced data browser and Quick-Batch function
Learn more about Shimadzu’s GC-2030. Visit us online at www.ssi.shimadzu.com/GC2030
50 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
⦁ Process
⦁ Analytical
⦁ Bio/Pharma
⦁ Oil & Gas
⦁ Refining
⦁ Petrochemical
⦁ Semiconductor
⦁ Corrosion
⦁ Coking/Fouling
⦁ Automotive
⦁ Aerospace
Major Products/Services Major Products/Services: SilcoTek offers
custom silicon coatings to OEMs and labs
worldwide. Send in your stainless steel,
alloy, glass, or ceramic part and we’ll ap-
ply our coatings in 10 days or less. Need
coated parts sooner?
⦁ SilcoNert®: The most inert coating
available.
⦁ Dursan®: An inert, high durability
coating. Ideal for lab and field analysis.
⦁ Silcolloy®: A high purity corrosion
resistant coating.
⦁ SilcoKlean®: Prevent carbon coking and
fouling in automotive and aerospace.
⦁ SilcoGuard®: A low outgassing, high
purity coating, ideal for research and
semiconductor applications.
⦁ Dursox®: A high purity corrosion-
resistant coating.
Facility SilcoTek applies coatings to customer-
supplied products from their 35,000 square
foot state-of-the-art facility located in
Bellefonte, Pennsylvania. They are currently
in the process of building an addition that
will double their size.
Want to speak to an expert about your
application?
Email [email protected]
or call +1 (814) 353-1778.
To find a sales representative nearest to you,
please visit
www.silcotek.com/international-reps
SilcoTek® Corporation
Company Description SilcoTek Corporation is the world’s leading provider of flow
path deactivations and coatings. Our patented CVD coating
technologies improve analytical reliability, increase system
uptime, and boost your bottom line. SilcoTek’s coatings are used
in a large, diverse variety of industries and applications where
analytical accuracy and superior performance are critical. Whether
for industry-leading chemical compatibility, corrosion resistance,
bio-inertness, or hydrophobicity, SilcoTek coatings will expand the
material limits of your instruments and products.
Chief Chromatographic Techniques Supported⦁ Sulfur analysis
⦁ VOC analysis
⦁ Environmental
⦁ Thermal desorption
⦁ Fenceline monitoring
⦁ CEMS
⦁ Flare subpart JA
⦁ Stack monitoring
⦁ Protein analysis
⦁ NOx, SOx testing
⦁ GC
⦁ LC
Markets Served SilcoTek coating technologies are utilized in diverse applications and
industry segments worldwide. Since 1987, customers have relied on
SilcoTek® coatings to improve the performance of their products and
increase revenue in the following markets and applications:
SilcoTek Corporation225 PennTech Drive,
Bellefonte, PA 16823
T E L E P H O N E
(814) 353-1778
F A X
(814) 353-1697
E - M A I L
W E B S I T E
www.SilcoTek.com
N U M B E R O F E M P L O Y E E S
54
W E B S I T E
www.SilcoTek.com
Y E A R F O U N D E D
2009
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 51www.chromatographyonline.com
⦁ Animal health
⦁ Anti-doping science
⦁ Biotechnological and pharmaceutical
research (synthesis, purification, charac-
terization, manufacturing)
⦁ Clinical diagnostics
⦁ Contract research and manufacturing
organizations (CRO and CMO)
⦁ Energy (petrochemical, biodiesel, and
alternative fuels development)
⦁ Environmental analysis
⦁ Food and beverage (food safety, nutra-
ceutical, natural product analysis)
⦁ Forensics, clinical, and toxicology testing
⦁ Fragrances and flavors
⦁ Generics manufacturing
⦁ Genomics, proteomics, and bioinformatics
research
⦁ Industrial processes
⦁ Proteins, peptides, and amino acids
manufacturing
Major Products/Services Separation & purification: HPLC and
LC–MS; flash chromatography (bulk or
pre-packed cartridges); preparative chroma-
tography; thin-layer chromatography (TLC);
sample preparation (FaPEx & QuEChERS);
solid-phase extraction (SPE and well plate)
Solid-supported scavenging solutions:
Metal, electrophile, nucleophile, and
genotoxic scavengers in bulk or E-PAK
Solid-supported reagents & catalysts:
Couplings; debenzylation; hydrogenation;
oxidation
Equipment: MiniBlock®
R&D Services: Catalyst development; col-
umn and cartridge packing; contaminants/
impurities identification; immobilization/
grafting of organic/inorganic molecules;
material characterization; method devel-
opment, and scale-up; screening (scaven-
gers, catalysis, medias)
Facility SiliCycle worldwide headquarters (QC,
Canada) is a new cutting-edge plant with a
multi-ton scale manufacturing capability. We
are actually expending our plant to increase
by 22x our manufacturing capacity as well
as being GMP compliant. SiliCycle has sales
offices in China, France, Germany, and India,
just to name a few. All products are available
worldwide.
SiliCycle® Inc.
Company Description Founded in 1995, SiliCycle is specialized in the development,
manufacturing, and commercialization of high value silica gels and
specialty products for chromatography, purification, and synthesis.
We design and manufacture unique grafted adsorbents and run
scale-up purification steps. SiliCycle products and services will help
our customers to solve their challenges, reach the highest product
quality needed, produce cheaper molecules in a cleaner way, and
shorten time-to-market. The X-Pure technology allows the possibil-
ity to bring to the market ultra-pure compounds and molecules
for various applications such as essential oils, probiotics, omega-3,
polyphenols and other active ingredients (CBD/THC).
Chief Chromatographic Techniques Supported ⦁ HPLC and LC–MS (column and bulk media)
⦁ Biochromatography
⦁ Supercritical fluid chromatography (SFC)
⦁ Size exclusion chromatography (SEC)
⦁ Gel permeation chromatography (GPC)
⦁ Large-scale fixed-bed purification (E-PAK)
⦁ Low pressure or flash chromatography (bulk & pre-packed
cartridges)
⦁ Preparative chromatography
⦁ Large-scale/process chromatography (40 kg cartridges)
⦁ Thin-layer chromatography (TLC)
⦁ Sample preparation (FaPEx & QuEChERS)
⦁ Solid-phase extraction (SPE and well plate)
⦁ Metal scavengers, normal, reversed, ion-exchanger, and chiral
media available
Markets Served ⦁ Academia and government industries
⦁ Aerospace and defense
⦁ Agrochemical (herbicides, pesticides, plant protection)
SiliCycle® Inc.2500, Parc-Technologique
Blvd., Quebec City (Quebec)
G1P 4S6
T E L E P H O N E
1 (418) 874-0054
Toll Free: 1 (877) 745-4292
F A X
1 (418) 874-0355
E - M A I L
W E B S I T E
www.silicycle.com
Y E A R F O U N D E D
1995
52 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Markets Served Sorbtech has deep expertise in
chromatography and purification and
develops lasting, strong client relationships.
Our broad product offering ensures
success—from simple lab procedures to
complex chromatographic techniques. We
assist from R&D method development to
process manufacturing: academia (organic,
bio-chemistry, bioprocess, polymer/material
science), government facilities (US FDA, NIH,
USDA, USGS, DOE), and industry chemists,
including CROs, CMOs, and manufacturing
(Pharma, Natural Products, Cannabis, Biofuel,
Materials, Food and Beverage).
Major Products/Services Sorbtech offers the expertise and breadth
of stationary phases: silica, bonded silicas,
scavengers, aluminas, polymeric resins,
SEC, and others to help you identify the
optimal product for method development to
scale-up. In addition to our comprehensive
selection of high-end chromatography and
lab equipment, Sorbtech provides concierge
level sales service to deliver value and ensure
our clients find the best fit solution for their
research. This helps shift the burden of
purchasing supplies from your shoulders
to Sorbtech’s, allowing your lab to focus on
what matters most—achieving innovative,
successful outcomes.
Facility Sorbtech is located in Norcross, Georgia,
within the Innovation Crescent—a
geographic area of economic development
entities dedicated to Georgia’s life science
and technology growth. Our facility includes
a state-of-the-art research and development
lab, production areas, and an efficient
warehouse that stores our vast inventory of
chromatography and purification products.
Sorbent Technologies, Inc.
Company Description Sorbent Technologies, Inc. specializes in products for
chromatography and purification to assist chemists with method
development and optimization—from analytical methods to full-
scale production with standard and complex chemistries. Sorbtech
provides solutions for universities, government labs, and industry—
including Pharma, Natural Products, Cannabis, Biofuel, Materials,
Food and Beverage, CMOs and CROs. Sorbtech offers one of the
industry’s broadest lines of highest quality products and has the
scientific expertise to assist clients with projects from lab to pilot to
industrial process applications. We deliver solutions for small, large,
and bio molecules, and synthetic and natural products.
Chief Chromatographic Techniques Supported⦁ Column chromatography: Flash, MPLC, and Gravity—bulk media,
cartridges, flash systems for laboratory
⦁ Size-Exclusion Chromatography (SEC): media and columns for
process purification of proteins and nucleic acids
⦁ Preparative Chromatography: columns and media for laboratory,
pilot, and process
⦁ Thin-Layer Chromatography (TLC): plates, adsorbents, TLC plate
cutter, accessories
⦁ High-Pressure Liquid Chromatography (HPLC/UPLC): columns
and adsorbents for LC–MS, analytical, semi-prep, prep
⦁ Solid-Phase Extraction (SPE): cartridges and 96 well plates
⦁ Gas Chromatography: capillary columns with low bleeding and
ultra-low bleeding
⦁ Sample Preparation: SPE cartridges and syringe filters
Sorbent Technologies, Inc.5595 Peachtree Corners East
Norcross, GA 30071
T E L E P H O N E
(770) 936-0323
Toll-free (866) 767-2832
F A X
(770) 936-0326
E - M A I L
W E B S I T E
www.sorbtech.com
Y E A R F O U N D E D
2000
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 53www.chromatographyonline.com
Major Products/Services Tosoh Bioscience offers a comprehensive
line of TSKgel prepacked columns for each of
the major chromatography modes, process
development tools, as well as TOYOPEARL,
TSKgel, and Ca++Pure-HA bulk resins for
laboratory scale purifications and process
chromatography.
Prepacked columns containing TSKgel
media are designed for the analysis of
proteins, peptides, other biopolymers, low
molecular weight compounds, and organic
soluble polymers. The packings in the
columns are either silica-based or polymer-
based material, in particle sizes ranging from
2 μm to 30 μm. Columns are available in
analytical through semi-preparative sizes, in
stainless steel, PEEK®, or glass.
A variety of screening tools composed of
TOYOPEARL and TSKgel process media are
available as an additional tool for convenient
scale-up. In addition, bulk media volumes of
<1 L are offered for process development.
The EcoSEC GPC System and the
EcoSEC High Temperature GPC System are
dedicated GPC instruments developed spe-
cifically for polymer analysis. These all-in-one
systems deliver top performance, reliability,
and superior results.
Facilities Tosoh Bioscience LLC is located in King of
Prussia, Pennsylvania. Supply chain offices
are in Grove City, Ohio. European operations
are in Griesheim, Germany. Asia is served by
Tosoh Corporation in Tokyo, Japan; Shang-
hai, China; and Singapore. Products are man-
ufactured by Tosoh Corporation in Japan.
Tosoh Bioscience LLC
Company Description Tosoh Bioscience LLC is a major supplier of chromatography prod-
ucts worldwide, particularly to the pharmaceutical, biotechnol-
ogy, and polymer industries. The company is a division of Tosoh
Corporation, a global chemical company with headquarters and
manufacturing facilities in Japan. Tosoh’s portfolio of over 500
TSKgel® and TOYOPEARL® products encompasses all common
modes of liquid chromatography. We manufacture analytical U/
HPLC columns and provide bulk chromatographic resins for the
purification of biopharmaceutical drugs in commercial manufac-
turing processes. Ca++Pure-HA®, a hydroxyapatite resin for biomol-
ecule purification, is a unique resin from Tosoh Bioscience in that
it is both the ligand and base bead. Tosoh Bioscience LLC offers
dedicated systems for polymer characterization, the EcoSEC GPC
System and the EcoSEC High Temperature GPC System.
Chief Chromatographic Techniques Supported ⦁ Size exclusion
⦁ Reversed phase, normal phase (hydrophilic interaction)
⦁ Ion exchange
⦁ Hydrophobic interaction
⦁ Affinity
⦁ Mixed-mode
Markets Served Located in King of Prussia, Pennsylvania, Tosoh Bioscience
LLC provides sales and service to pharmaceutical and
biotechnology customers in North and South America.
Tosoh Bioscience LLC3604 Horizon Drive
Suite 100
King of Prussia, PA 19406
T E L E P H O N E
(484) 805-1219
(800) 366-4875
F A X
(610) 272-3028
E - M A I L
W E B S I T E
www.tosohbioscience.com
N U M B E R O F E M P L O Y E E S
35
Y E A R F O U N D E D
1987
54 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Markets Served ⦁ Clinical
⦁ Environmental
⦁ Food safety
⦁ Forensic
⦁ Pharmaceutical
⦁ Veterinary
Major Products/Services ⦁ CLEAN SCREEN® SPE columns
⦁ CLEAN SCREEN FASt® columns
⦁ CLEAN SCREEN XCEL® SPE columns
⦁ CLEAN UP® SPE columns
⦁ STYRE SCREEN® SPE columns
⦁ XtrackT® SPE columns
⦁ ENVIRO-CLEAN® SPE cartridges
⦁ ENVIRO-CLEAN® universal cartridges
⦁ Chlorofiltr® Sorbents
⦁ QuEChERS
⦁ Quick QuEChERS
⦁ SpinFiltr™
⦁ SELECTRA® HPLC columns
⦁ SELECTRASORB bulk sorbents
⦁ SELECTRA-SIL® derivatizing reagents
⦁ SELECTRAZYME® β-glucuronidase
⦁ ABALONASE™ β-glucuronidase
⦁ SELECT pH buffer pouches
⦁ GC liners
⦁ Positive pressure manifolds
⦁ Vacuum manifolds
Facility UCT is headquartered in Bristol,
Pennsylvania, with a research facility in
Scranton, Pennsylvania. Manufacturing
and distribution sites are in Lewistown,
Pennsylvania, and Wexford, Ireland. UCT
is represented worldwide by over 47
partners and distributors.
UCT, Inc.
Company Description UCT is always at the forefront of sample preparation technology
and a leader in chromatography consumables. The company’s
wide range of highly reproducible silica and polymeric SPE
sorbents provides scientists a consistent extraction technique.
UCT is in a unique position within the sample prep and
chromatographic sorbent industry; we are one of the few
manufacturers of chromatographic silane materials. This expertise
provides us with greater control and extensive knowledge of the
chemical processes involved in producing high quality bonded
phases. UCT’s commitment to ensuring customer satisfaction
is accomplished by delivering on our promises: top quality,
reproducible chromatographic and sample prep products, and
unmatched technical support. The company’s sample prep
product lines include SPE cartridges and well plates, flash
chromatography columns, bulk sorbents, QuEChERS tubes,
derivatizing reagents, hydrolyzing enzymes, premeasured buffer
salts, and extraction manifolds; chromatography products include
HPLC columns and GC liners. All products are designed to meet
laboratory sample prep and chromatography needs.
Chief Chromatographic Techniques Supported ⦁ Solid-phase extraction
⦁ QuEChERS
⦁ HPLC
UCT, Inc.2731 Bartram Road
Bristol, PA 19007
T E L E P H O N E
(215) 781-9255
F A X
(215) 785-1226
E - M A I L
W E B S I T E
www.unitedchem.com
N U M B E R O F E M P L O Y E E S
>100
Y E A R F O U N D E D
1986
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 55www.chromatographyonline.com
Precision Sampling manufactures analytical
quality syringes, sampling probes, as well as
standard and custom formed stainless and
special alloy tubing. VICI AG International
produces some Valco products as well as
the Jour line of HPLC fittings and lab safety
products. VICI DBS builds our new line of
laboratory hydrogen, nitrogen, and zero air
gas generators.
Our newest products include the C82 line
of UHPLC valves, fittings that permit direct
connection of 360 μm tubing, the Universal
valve actuator, and the C52 platform
integrated HPLC injectors and selectors.
Facility With over 150 state-of-the-art CNC
machines, our instruments and
components are manufactured to exacting
standards at our facilities in Houston,
USA, and Schenkon, Switzerland. Our
other manufacturing facilities include VICI
Metronics in Washington, VICI Precision
Sampling in Louisiana, and VICI DBS
located in Italy. VICI Canada serves our
neighbor to the north from its offices in
Brockville, Ontario.
Valco Instruments Co., Inc. (VICI)
Company Description Founded in 1968, VICI is an international group of
companies. Our products can be found in nearly every
national lab, military facility, and university research
department around the globe. For 50 years VICI has driven
the field of chromatography with valves, fittings, detectors,
and instruments for precision analytical, biomedical, and
biocompatible applications. We also customize components
and complete systems to improve chromatographic analyses.
Chief Chromatographic Techniques Supported ⦁ High Pressure Liquid Chromatography
⦁ Liquid Chromatography
⦁ Gas Chromatography
⦁ Flow Injection Analysis
⦁ Supercritical Fluid Chromatography
⦁ Gas Permeation Chromatography
⦁ Process Gas Chromatography
Major Products/Services VICI produces a complete line of valves for analytical chemistry.
We specialize in zero dead volume fittings and filters for the
separation sciences and are the original creators of the pulse
discharge detector (PDD). Our miniPDD consumes less than
one-fifth the amount of helium required by the PDDs used on
complete GC systems. It has similar sensitivity to the original
PDD with a slightly lower dynamic range.
Our VICI Metronics division produces PEEK, FEP, PFA, and
ETFE tubing, ambient temperature gas purifiers, ValcoBond GC
capillary columns, and Dynacal gas calibration standards. VICI
Valco Instruments Co., Inc. (VICI)
P.O. Box 55603
Houston, TX 77255
T E L E P H O N E
(800) 367-8424
F A X
(713) 688-8106
E - M A I L
W E B S I T E
www.vici.com
N U M B E R O F E M P L O Y E E S
US: 365
Europe: 135
Y E A R F O U N D E D
1968
56 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
maceutical, industrial chemical, and envi-
ronmental customers in North and South
America.
Major Products/Services ⦁ YMC-Triart
⦁ YMC-BioPro
⦁ Meteoric Core (Core-shell)
⦁ Chiral, CHIRAL ART: Amylose-C,
Amylose-C Neo, Cellulose-C, Amylose-SA,
Cellulose-SB, Cellulose-SC; Cellulose-SJ;
YMC Chiral Series: NEA (R), (S), α-CD
BR, β-CD BR, γ-CD BR
⦁ Reversed-phase, ODS: YMC-Triart C18
and C18 ExRS, Meteoric Core C18 and
C18 BIO; Pro Series: Pro C18, Hydro-
sphere C18, Pro C18 RS; YMC-Pack
ODS Series: ODS-A, ODS-AM, ODS-AQ,
ODS-AL; J’sphere ODS: ODS-H80, ODS-
M80, ODS-L80; YMC-Pack PolymerC18
⦁ Other than ODS: YMC-Triart Bio C4
YMC-Triart C8, Phenyl, and PFP; Meteoric
Core C8; Pro C8; Pro C4; YMCbasic, YMC
Carotenoid; YMC-Pack Series: C8, C4,
TMS, Ph (Phenyl), CN (Cyano), Protein-RP,
YMCbasic, YMC Carotenoid
⦁ Normal phase: YMC-Triart Diol-HILIC;
YMC-Pack Series: SIL, SIL-06, Diol-NP,
CN, PVA-Sil, Polyamine II, NH2, PA-G
⦁ Ion-Exchange, YMC-BioPro Series:
QA (porous quaternary amine anion
exchange), SF (porous sulfopropyl cation
exchange), QA-F (non-porous QA), SP-F
(non-porous SF)
⦁ Size-Exclusion, YMC-Pack Series:
Diol-60, Diol-120, Diol-200, Diol-300;
YMC-SEC MAB, YMC-GPC
⦁ Hydrophobic Interaction: YMC-BioPro
HIC BF
In addition to all of YMC’s analytical chroma-
tography offerings, most chromatography
chemistries are scalable to bulk packing ma-
terials for lab-scale and production-scale puri-
fications. YMC also offers preparative systems
for discovery, pilot-scale, and production.
Facilities YMC America, Inc. – Allentown, Pennsylvania
YMC Co., Ltd. – Kyoto, Tokyo, Japan
YMC Europe GmbH – Dinslaken, Germany
YMC India Pvt. Ltd. – New Delhi, India
YMC China – Shanghai, China
YMC Korea Co., Ltd. – Gyeonggi-do, Korea
YMC Taiwan Co., Ltd. – Taipei City, Taiwan
YMC Singapore Tradelinks Pte, Ltd. –
Singapore
YMC Schweiz GmbH – Basel, Switzerland
YMC America, Inc.
Company Description YMC America, Inc., is the exclusive sales and support channel for
separations leader YMC Co., Ltd., whose products include station-
ary phase chemistries primarily used for high and low pressure
separation science. Stationary phases designed for use with
high performance liquid and supercritical fluid chromatography
techniques are available as stocked standard items and custom
products are available for specialized application needs. Products
bonded to spherical silica, hybrid silica, and polymeric-based par-
ticles ranging in size from 1.9 to 150 μm are available in packed
columns or in bulk chemical packaging formats. YMC America
maintains offices, application support laboratories, and a ware-
house in Allentown, Pennsylvania, and manages the applications
support and sub-distribution of YMC products throughout the
Western hemisphere, either through direct contact with its cus-
tomers or via a network of distributors throughout the Americas.
YMC products are available on a world-wide basis.
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ UHPLC
⦁ Supercritical fluid chromatography (SFC)
⦁ Chiral chromatography
⦁ Hydrophobic interaction chromatography (HIC)
⦁ Ion-exchange (biomolecules) chromatography
⦁ Size-exclusion chromatography (SEC)
⦁ Preparative chromatography
⦁ HILIC chromatography
⦁ Superficially porous particle (core-shell) chromatography
⦁ Nano–capillary chromatography
⦁ Preparative chromatography systems
⦁ Flow reactor chemistry
Markets Served Located in Allentown, Pennsylvania, YMC America, Inc., provides
sales and service to pharmaceutical, biotechnology, biophar-
YMC America, Inc.941 Marcon Blvd.
Suite 201
Allentown, PA 18109
T E L E P H O N E
(610) 266-8650
F A X
(610) 266-8652
E - M A I L
W E B S I T E
www.ymcamerica.com
N U M B E R O F E M P L O Y E E S
Worldwide: 350
Y E A R F O U N D E D
1980
www.ymcamerica.com • [email protected]
Any Format
Bulk supply and columns for capillary
LC, Fast LC, UHPLC, HPLC, semi-prep, prep, SMB, SFC.
Any Format
Bulk supply and columns for capillary
LC, Fast LC, UHPLC, HPLC, semi-prep, prep, SMB, SFC.
AnyApplication
Biomolecules, smallmolecule APIs,
chemicals, naturalproducts, much
more.
AnyApplication
Biomolecules, smallmolecule APIs,
chemicals, naturalproducts, much
more.
Any ScaleYMC supports
separations fromcapillary to process
manufacturing.
Any ScaleYMC supports
separations fromcapillary to process
manufacturing.AnywhereYMC Group delivers global availability
and support.
AnywhereYMC Group delivers global availability
and support.
Any ModePhases include reversed
phase, normal phase,HIC, HILIC, core-shell,chiral, SEC, and IEX.
Any ModePhases include reversed
phase, normal phase,HIC, HILIC, core-shell,chiral, SEC, and IEX.
58 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
Major Products/Services WTC’s family of instruments include:
⦁ DAWN: An 18-angle SEC-MALS instrument
used at ambient, elevated, and below am-
bient temperatures for polymers, particles,
and biopolymers.
⦁ miniDAWN: A SEC-MALS instrument ideal
for proteins and peptides and molar mass
materials below 1 million Da.
⦁ μDAWN: The world’s first MALS instrument
for UHPLC. Compatible with all UHPLCs for
molar mass and size determinations.
⦁ Eclipse FFF system: For separation of mac-
romolecules and nanoparticles in solution..
⦁ Optilab TrEX: The most advanced RI de-
tector in the world with 256 times the
detection power and 50 times the dynamic
range of any other RI detector. The TrEX can
be operated below or above ambient tem-
perature and determine dn/dc at the same
wavelength of light as the light scattering
instrument.
⦁ Optilab UT-rEX: The world’s first refractive
index (RI) detector for UHPLC. Operates
at the same wavelength of light as the
μDAWN.
⦁ WyattQELS: A dynamic light-scattering
module integrated with the DAWN or
miniDAWN to determine particle sizes as
small as 1 nm.
⦁ ViscoStar viscometer: A state-of-the-art
intrinsic viscosity instrument that can be
operated above or below ambient tem-
perature with its precise Peltier thermo-
static controls.
Facility WTC maintains more than 60,000 square
feet of R&D, manufacturing and application
laboratories in Santa Barbara, California, USA.
Wyatt Technology
Company Description Wyatt Technology, a 35-year old family-owned and operated
enterprise, is the world’s largest company dedicated to SEC-MALS
instruments for absolute macromolecular characterization. Our
products provide techniques for characterizing macromolecules
and nanoparticles in solution, in order to determine molar mass,
size, charge, and interactions. Wyatt’s extensive applications
laboratories and its full-time staff (including more than 25 PhD
scientists) means our customers receive deep technical expertise
and support. To ensure the personal touch, “Light Scattering
University” (LSU) is included with most instrument purchases.
We bring you to Santa Barbara, CA, to demystify light scattering
and explain how to get the most from your Wyatt Technology
equipment. Because we don’t just build instruments, we build
relationships.
Chief Chromatographic Techniques Supported ⦁ SEC & GPC
⦁ UHPLC & APC
⦁ Field-flow fractionation
Markets Served Wyatt’s products are the most widely used multi-angle
light scattering (MALS) instruments in the world. They are
employed in thousands of laboratories, including companies
involved in biotechnology, pharmaceutical development, and
chemical/petrochemical research, in addition to government
national laboratories and academic facilities.
Wyatt Technology6330 Hollister Ave.,
Santa Barbara, CA 93117,
USA
T E L E P H O N E
(805) 681 9009
E - M A I L
W E B S I T E
www.wyatt.com
Y E A R F O U N D E D
1982
DECEMBER 2018 LCGC NORTH AMERICA CORPORATE CAPABILITIES 59www.chromatographyonline.com
Markets Served Pharmaceutical, nutraceutical, basic
science research, antibody purification,
food and cosmetics, chemical
manufacturing (pesticides, polymers),
and biological research (phosphopeptide
enrichment)
Major Products/Services ZirChrom offers a full line of zirconia- and
titania-based HPLC products for chromato-
graphic method development. ZirChrom
HPLC products offer unique selectivity, ex-
acting reproducibility, high efficiency, and
ultra-stability. All phases are available in
packed, prep, semi-prep, bulk, microbore,
and SPE formats:
Reversed Phase (Diamondbond®-C18,
ZirChrom®-CARB, ZirChrom®-EZ,
ZirChrom®-MS, ZirChrom®-PBD,
ZirChrom®-PS, Sachtopore®-RP);
Ion-Exchange (ZirChrom®-PEZ,
ZirChrom®-SAX, ZirChrom®-SHAX,
ZirChrom®-WAX, ZirChrom®-WCX);
Other/Specialty (ZirChrom®-PHASE,
Rhinophase®-AB, Sachtopore®-NP)
Facilities ZirChrom is headquartered in Anoka,
Minnesota, and has distributors
worldwide.
ZirChrom Separations, Inc.
Company Description ZirChrom Separations, Inc. is a company that was formed
in 1995 and is located in Anoka, Minnesota. ZirChrom
manufactures a full line of zirconia- and titania-based high
performance chromatographic materials for the analytical
analysis of compounds primarily by high performance liquid
chromatography (HPLC).
Chief Chromatographic Techniques Supported ⦁ HPLC
⦁ Semi-prep chromatography
⦁ Prep chromatography
⦁ Ion exchange chromatography
⦁ Reversed phase chromatography
⦁ HILIC
⦁ Sample prep
⦁ Multi-modal chromatography
⦁ Pseudo-affinity chromatography
⦁ Bulk materials
⦁ Microbore-HPLC
⦁ UHPLC/Sub-2 micron
ZirChrom Separations, Inc.617 Pierce Street
Anoka, MN 55303
T E L E P H O N E
(763) 421-5264
F A X
(763) 421-2319
E - M A I L
W E B S I T E
www.zirchrom.com
Y E A R F O U N D E D
1995
60 THE APPLICATION NOTEBOOK – DECEMBER 2018
MEDICAL/BIOLOGICAL
Analysis of Fentanyl and Its
Analogues in Human Urine
by LC–MS/MSShun-Hsin Liang and Frances Carroll, Restek Corporation
Abuse of synthetic opioid prescription painkillers such as
fentanyl, along with a rapidly growing list of illicit analogues,
is a signifi cant public health problem. In this study, we
developed a simple dilute-and-shoot method that provides
a fast 3.5-min analysis of fentanyl and related compounds
(norfentanyl, acetyl fentanyl, alfentanil, butyryl fentanyl,
carfentanil, remifentanil, and sufentanil) in human urine by
LC–MS/MS using a Raptor Biphenyl column.
In recent years, the illicit use of synthetic opioids has
skyrocketed, and communities worldwide are now dealing
with an ongoing epidemic. Of the thousands of synthetic
opioid overdose deaths per year, most are related to fentanyl
and its analogues. With their very high analgesic properties,
synthetic opioid drugs such as fentanyl, alfentanil, remifentanil,
and sufentanil are potent painkillers that have valid medical
applications; however, they are also extremely addictive and
are targets for abuse. In addition to abuse of these prescription
drugs, the current opioid crisis is fueled by a growing number
of illicit analogues, such as acetyl fentanyl and butyryl fentanyl,
which have been designed specifically to evade prosecution by
drug enforcement agencies.
As the number of opioid drugs and deaths increases, so does
the need for a fast, accurate method for the simultaneous analysis
of fentanyl and its analogues. Therefore, we developed this LC–
MS/MS method for measuring fentanyl, six analogues, and one
metabolite (norfentanyl) in human urine. A simple dilute-and-shoot
sample preparation procedure was coupled with a fast (3.5 min)
0.00 0.20 0.40 0.60 0.80 1.00 1.20 1.40 1.60 1.80 2.00 2.20 2.40 2.60 2.80 3.00
Time (min)
Figure 1: The Raptor Biphenyl column effectively separated all target compounds in urine with no observed matrix interferences. Peak elution order: norfentanyl-D5, norfentanyl, remifentanil, acetyl fentanyl-13C6, acetyl fentanyl, alfentanil, fentanyl-D5, fentanyl, carfentanil-D5, carfentanil, butyryl fentanyl, sufentanil-D5, sufentanil.
Table I: Analyte transitions
AnalytePrecursor
Ion
Product Ion
Quantifi er
Product Ion
Qualifi erInternal Standard
Norfentanyl 233.27 84.15 56.06 Norfentanyl-D5
Acetyl fentanyl 323.37 188.25 105.15 Acetyl fentanyl-13C6
Fentanyl 337.37 188.26 105.08 Fentanyl-D5
Butyryl fentanyl 351.43 188.20 105.15 Carfentanil-D5
Remifentanil 377.37 113.15 317.30 Norfentanyl-D5
Sufentanil 387.40 238.19 111.06 Sufentanil-D5
Carfentanil 395.40 113.14 335.35 Carfentanil-D5
Alfentanil 417.47 268.31 197.23 Acetyl fentanyl-13C6
Norfentanyl-D5
238.30 84.15 — —
Acetyl fentanyl-13C6
329.37 188.25 — —
Fentanyl-D5
342.47 188.27 — —
Sufentanil-D5
392.40 238.25 — —
Carfentanil-D5
400.40 340.41 — —
chromatographic analysis using a Raptor Biphenyl column. This
method provides accurate, precise identifi cation, and quantitation
of fentanyl and related compounds, making it suitable for a variety
of testing applications, including clinical toxicology, forensic
analysis, workplace drug testing, and pharmaceutical research.
Experimental Conditions
Sample Preparation
The analytes were fortifi ed into pooled human urine. An 80 μL
urine aliquot was mixed with 320 μL of 70:30 water–methanol so-
lution (fi vefold dilution) and 10 μL of internal standard
(40 ng/mL in methanol) in a Thomson SINGLE StEP fi l-
ter vial (Restek cat. #25895). After fi ltering through the
0.2 μm PVDF membrane, 5 μL was injected into the
LC–MS/MS.
Calibration Standards
and Quality Control Samples
The calibration standards were prepared in pooled hu-
man urine at 0.05, 0.10, 0.25, 0.50, 1.00, 2.50, 5.00,
10.0, 25.0, and 50.0 ng/mL. Three levels of QC samples
(0.75, 4.0, and 20 ng/mL) were prepared in urine for
testing accuracy and precision with established cali-
bration standard curves. Recovery analyses were per-
formed on three different days. All standards and QC
samples were subjected to the sample preparation pro-
cedure described.
LC–MS/MS analysis of fentanyl and its analogues was
performed on an ACQUITY UPLC instrument coupled
THE APPLICATION NOTEBOOK – DECEMBER 2018 61
MEDICAL/BIOLOGICAL
with a Waters Xevo TQ-S mass spectrometer. Instrument conditions
were as follows, and analyte transitions are provided in Table I.
Analytical column: Raptor Biphenyl (5 μm,
50 mm × 2.1 mm; cat. #9309552)
Guard column: Raptor Biphenyl EXP guard column
cartridge, (5 μm, 5 mm × 2.1 mm;
cat. #930950252)
Mobile phase A: 0.1% Formic acid in water
Mobile phase B: 0.1% Formic acid in methanol
Gradient Time (min) %B
0.00 30
2.50 70
2.51 30
3.50 30
Flow rate: 0.4 mL/min
Injection
volume: 5 μL
Column temp.: 40 °C
Ion mode: Positive ESI
Results
Chromatographic Performance
All eight analytes were well separated within a 2.5-min gradient
elution (3.5-min total analysis time) on a Raptor Biphenyl column
(Figure 1). No signifi cant matrix interference was observed to neg-
atively affect quantifi cation of the fi vefold diluted urine samples.
The 5-μm particle Raptor Biphenyl column used here is a superfi -
cially porous particle (SPP) column. It was selected for this meth-
od in part because it provides similar performance to a smaller
particle size fully porous particle (FPP) column, but it generates
less system back pressure.
Linearity
Linear responses were obtained for all compounds and the calibra-
tion ranges encompassed typical concentration levels monitored
for both research and abuse. Using 1/x weighted linear regression
(1/x2 for butyryl fentanyl), calibration linearity ranged from 0.05
to 50 ng/mL for fentanyl, alfentanil, acetyl fentanyl, butyryl fen-
tanyl, and sufentanil; from 0.10 to 50 ng/mL for remifentanil; and
from 0.25 to 50 ng/mL for norfentanyl and carfentanil. All analytes
showed acceptable linearity with r2 values of 0.996 or greater and
deviations of <12% (<20% for the lowest concentrated standard).
Accuracy and Precision
Based on three independent experiments conducted on multiple
days, method accuracy for the analysis of fentanyl and its ana-
logues was demonstrated by the %recovery values, which were
within 10% of the nominal concentration for all compounds at all
QC levels. The %RSD range was 0.5–8.3% and 3.4–8.4% for in-
traday and interday comparisons, respectively, indicating accept-
able method precision (Table II).
Conclusions
A simple dilute-and-shoot method was developed for the quantita-
tive analysis of fentanyl and its analogues in human urine. The
analytical method was demonstrated to be fast, rugged, and sen-
sitive with acceptable accuracy and precision for urine sample
analysis. The Raptor Biphenyl column is well suited for the analy-
sis of these synthetic opioid compounds and this method can be
applied to clinical toxicology, forensic analysis, workplace drug
testing, and pharmaceutical research.
Restek Corporation110 Benner Circle, Bellefonte, PA 16823
tel. 1 (814) 353-1300
Website: www.restek.com
Table II: Accuracy and precision results for fentanyl and related compounds in urine QC samples
QC Level 1 (0.750 ng/mL) QC Level 2 (4.00 ng/mL) QC Level 3 (20.0 ng/mL)
AnalyteAverage Conc.
(ng/mL)
Average %
Accuracy %RSD
Average Conc.
(ng/mL)
Average %
Accuracy %RSD
Average Conc.
(ng/mL)
Average %
Accuracy %RSD
Acetyl fentanyl 0.761 102 1.54 3.99 99.7 2.08 19.9 99.3 0.856
Alfentanil 0.733 97.6 3.34 3.96 98.9 8.38 20.9 104 6.73
Butyryl fentanyl 0.741 98.9 6.29 3.77 94.3 6.01 20.8 104 4.95
Carfentanil 0.757 101 7.34 3.76 94.0 4.64 20.6 103 4.24
Fentanyl 0.761 102 1.98 3.96 99.1 2.31 19.9 99.6 1.04
Norfentanyl 0.768 103 6.50 4.04 101 1.84 20.1 101 2.55
Remifentanil 0.765 102 3.42 3.97 99.2 3.68 20.8 104 4.14
Sufentanil 0.752 100 1.67 3.93 98.3 1.28 20.1 100 0.943
62 THE APPLICATION NOTEBOOK – DECEMBER 2018
ENVIRONMENTAL
Optimization of Sample Preparation for Pesticide Analysis
in Oil-Based Cannabis Products Using LipiFiltr®
Brian Kinsella,* Bikash Bhattarai,* Julie Kowalski,† Derek Laine,† Sara Minier,† Aimee Soule,†and Gwen Bode† *UCT, LLC, †Trace Analytics
This application note outlines the performance benefi ts achieved
with UCT’s LipiFiltr cleanup cartridge for the analysis of pesticides
in oil-based cannabis products using LC–MS/MS analysis. The
pesticides evaluated in this study include those listed in the
Oregon monitoring list (≈60 pesticides). Cannabidiol (CBD) oil
was used as the representative matrix. A comparison of pre- and
post-LipiFiltr® cleanup using full-scan GC–MS is also presented
to demonstrate the removal of lipid co-extractives, without
compromising cannabinoid content.
Extraction/Analytical Materials
LPFLTR01 LipiFiltr push-through cartridge
Procedure
Sample Extraction
1. Weigh 1 g of sample into a 50-mL polypropylene centrifuge tube.
2. Add internal standard(s).
3. Add 10 mL of extraction solvent (acetonitrile/water/toluene,
90/5/5, v/v).
4. Shake or vortex the sample for 1 h.
5. Centrifuge the sample at ≥1500 rcf for 5 min.
6. Pass 1.5 mL supernatant through a LipiFiltr cartridge
and collect the purifi ed extract in an autosampler vial.
Instrumental
Pesticide Recovery
LC–MS/MS: SCIEX Triple Quad 6500+ with SCIEX V Method™ for
pesticides in cannabis
Co-extractives Removal
GC–MS: Rxi-5Sil MS column (30 m × 0.25 mm × 0.25 μm) with a
Topaz Precision split inlet liner. A 1-μL injection volume with a split
ratio of 10:1 was used.
Results/Conclusion
Pesticides
• Most compounds were found to have a recovery value in the
range of 70–120%.
• A few polar compounds, such as acephate, exhibited low but
reproducible (<10% RSD) recovery.
• Increasing the polarity of the extraction solvent or using a
suitable isotopically labelled internal standard could be used
to correct any discrepancy in recovery.
GC–MS (full scan) analysis showed signifi cant removal of lipids and
other high molecular weight matrix co-extractives using the LipiFiltr
cartridge, with no signifi cant negative effect on CBD. This was
backed up by LC-DAD analysis (not detailed here). While further
work should be completed on other oil-based products, including
those with a high THC content, the results highlighted here
demonstrate that the LipiFiltr cartridge can be successfully used
to remove matrix co-extractives from oil-based cannabis samples
without compromising CBD content or pesticide recoveries.
UCT, LLC2731 Bartram Road Bristol, PA 19007
tel. +1 (215) 781-9255
Website: www.unitedchem.com
Figure 1: Clockwise from top left: Comparison of hexadecanoic acid content, octadecadienoic and octadecatrienoic acids, and can-nabidiol content pre- and post- LipiFiltr cleanup in a CBD oil extract.
THE APPLICATION NOTEBOOK – DECEMBER 2018 63
PHARMA/DRUG DISCOVERY
High pH and Elevated Temperatures for
Fast Separation of Strongly Basic Drug CompoundsDerek A. Jensen and Mark Carrier, Hamilton Company
Two important but frequently underutilized tools in meth-
ods development are mobile-phase pH and elevated tem-
peratures. Hamilton’s PRP-C18 column is well-suited for high
pH and high temperature applications because the polymer-
based stationary phase is chemically inert and has excellent
thermal stability above 100 °C.
In modern drug discovery, where analytical HPLC can be a bottle-
neck, production is streamlined through the use of shorter columns
with smaller particles, operated at higher fl ow rates. The fl exibility to
employ a high pH mobile phase and elevated temperatures repre-
sents further valuable tactics in methods development. These tools,
often underutilized or not practical with silica-based columns, en-
able rapid separation of closely-related basic solutes in their charge-
neutral forms that would otherwise be coeluted under non-alkaline,
ambient temperature conditions.
In this study, nine structurally-diverse, strongly basic drug com-
pounds are resolved in less than 2 min using a high pH mobile
phase and a fast acetonitrile gradient at 80 °C.
Hamilton Company4970 Energy Way, Reno, NV 89502
tel. (775) 858-3000, (800) 648-5950
Website: www.hamiltoncompany.com
3
5 6
7
94
1
0.0 1.0
Time (min)
2.0 3.0
28
Figure 1: Fast separation of structurally-diverse, basic solutes at 80 °C.
Column: Hamilton PRP-C18, 5 μm, 2.1 x 33 mm
Flow rate: 1.0 mL/min
Temperature: 80 °C
Injection volume: 5 μL
Flow rate: 1.0 mL/min
Mobile phase: A) 30 mM diethylamine (pH 11.5)
B) Acetonitrile + 30 mM diethylamine
Gradient: 2 to 99% B in 1 min
Detection: UV at 254 nm
Analytes
1. Ephedrine
2. Norephedrine
3. Nicotine
4. Metoprolol
5. Quinine
6. Doxylamine
7. Diphenhydramine
8. Nortriptyline
9. Amitriptyline
64 THE APPLICATION NOTEBOOK – DECEMBER 2018
PHARMA/DRUG DISCOVERY
Separation of Lactulose and Epilactose Leah Sullivan, Showa Denko America, Inc.
Lactulose, a semi-synthetic disaccharide, is a useful indicator for
heat-induced modifi cations in milk. Lactulose can be derived from
lactose by alkaline isomerization or enzymatic transgalactosylation
of fructose. Once in solution, lactulose is less stable in than lactose
in an alkaline environment and can degrade into galactose, tagatose,
and low-molecular-weight acids.
The United States Pharmacopeia (USP) describes the separation
of lactulose together with lactose and galactose, as well as traces of
other related sugars. The USP method describes high performance
liquid chromatography (HPLC) separation achieved on an L8 amino
propyl functionalized silica support column. Herein, we describe
an improved separation for lactulose, epilactose, and lactose on
Shodex VG-50 4E, an amino hydrophilic interaction (HILIC) column.
Shodex uses the VG-50 4E column packed with a durable
polymer-based packing material modifi ed with chemically stable
tertiary amino functional groups. The Shodex VG-50 4E is suitable
for saccharide analysis and provides a fast, reliable method for the
determination of lactose and lactulose.
Experimental Conditions
The analysis of three disaccharides is accomplished with Shodex
VG-50 4E (4.6 mm ID × 250 mm, 5 μm), a polymer-based amino
HILIC column. The column temperature was 40 ºC and the fl ow rate
was 1.0 mL/min for the VG-50 4E analysis. Eluent conditions were
75:20:5 acetonitrile–methanol–water. An injection volume of 5 μL
of 5 mg/mL of each sugar was used for the experiment. The HPLC
system was coupled with a refractive index (RI) detector.
Results
Lactulose, lactose, and epilactose were analyzed successfully by HPLC
and RI detection with VG-50 4E (Figure 1). The Shodex VG-50 4E
demonstrates baseline separation of the three sugars with an elution time
of less than 15 min with the elution order of lactulose, then epilactose,
and fi nally lactose. The USP monograph describes the elution order
as fi rst epilactose, lactose, and then lactose with resolution between
lactulose and lactose not less than 1.5 and resolution between lactulose
and epilactose not less than 0.9. The Shodex analysis demonstrates
resolution between lactulose and epilactose as 2.29 and resolution
between epilactose and lactose as 1.98.
Conclusions
The Shodex VG-50 4E, a polymer-based HILIC chromatography
column, is suitable for the analysis of lactulose, epilactose, and
lactose.
Shodex™/Showa Denko America, Inc.420 Lexington Avenue Suite 2335A, New York, NY, 10170
tel. (212) 370-0033 x109
Website: www.shodexHPLC.com
TM
Figure 1: Separation of lactulose and epilactose. Column: Shodex VG-50 4E; column temperature: 40 ºC; injection volume: 5 μL; elu-
ent: acetonitrile–methanol–water = 75:20:5; fl ow rate: 1.0 mL/min. Detector: Shodex RI. Sample: 1. lactulose 2. epilactose 3. lactose.
THE APPLICATION NOTEBOOK
Call for Application Notes
LCGC is planning to publish the next issue of
Th e Application Notebook special supplement in
February. Th e publication will include vendor
application notes that describe techniques and
applications of all forms of chromatography
and capillary electrophoresis that are of im-
mediate interest to users in industry, academia,
and government. If your company is interested
in participating in these special supplements,
contact:
Edward Fantuzzi, Publisher,
(732) 346-3015
Brianne Molnar, Sales Manager,
(732) 346-3034
Stephanie Shaff er, Sales Manager,
(774) 249-1890
Application Note Preparation
It is important that each company’s mate-
rial fi t within the allotted space. Th e editors
cannot be responsible for substantial editing
or handling of application notes that deviate
from the following guidelines:
Each application note page should be no more
than 500 words in length and should follow
the following format:
• Title: short, specifi c, and clear
• Abstract: brief, one- or two-
sentence abstract
• Introduction
• Experimental Conditions
• Results
• Conclusions
• References
• Two graphic elements: one is the company
logo; the other may be a sample chromato-
gram, fi gure, or table
• Th e company’s full mailing address,
telephone number, fax number,
and Internet address
All text will be published in accordance with
LCGC ’s style to maintain uniformity through-
out the issue. It also will be checked for gram-
matical accuracy, although the content will not
be edited. Text should be sent in electronic for-
mat, preferably using Microsoft Word.
Figures
Refer to photographs, line drawings, and
graphs in the text using arabic numerals in
consecutive order (Figure 1, etc.). Company
logos, line drawings, graphs, and charts must
be professionally rendered and submitted as
.TIF or .EPS fi les with a minimum resolution
of 300 dpi. Lines of chromatograms must be
heavy enough to remain legible after reduc-
tion. Provide peak labels and identifi cation.
Provide fi gure captions as part of the text,
each identifi ed by its proper number and title.
If you wish to submit a fi gure or chromato-
gram, please follow the format of the sample
provided below.
Tables
Each table should be typed as part of the main
text document. Refer to tables in the text by
Roman numerals in consecutive order (Table
I, etc.). Every table and each column within
the table must have an appropriate heading.
Table number and title must be placed in a
continuous heading above the data presented.
If you wish to submit a table, please follow
the format of the sample provided below.
References
Literature citations must be indicated by ara-
bic numerals in parentheses. List cited refer-
ences at the end in the order of their appear-
ance. Use the following format for references:
(1) T.L. Einmann and C. Champaign, Science
387, 922–930 (1981).
Th e deadline for submitting application notes for the February issue of Th e Application Notebook is:
January 11, 2019
Th is opportunity is limited to advertisers in LCGC North America. For more information, contact: Ed Fantuzzi at (732) 346-3015,
Brianne Molnar at (732) 346-3034, or Stephanie Shaff er at (774) 249-1890
Table I: Factor levels used in the designs
Factor Nominal Value Lower Level (−1) Upper Level (+1)
Gradient profile 1 0 2
Column temperature (°C) 40 38 42
Buffer concentration 40 36 44
Mobile-phase buffer pH 5 4.8 5.2
Detection wavelength (nm) 446 441 451
Triethylamine (%) 0.23 0.21 0.25
Dimethylformamide 10 9.5 10.5
Figure 1: Chromatograms obtained us-ing the conditions under which the ion suppression problem was originally dis-covered. The ion suppression trace is shown on the bottom. Column: 75 mm × 4.6 mm ODS-3; mobile-phase A: 0.05% heptafl uorobutyric acid in water; mobile-phase B: 0.05% heptafl uorobutyric acid in acetonitrile; gradient: 5–30% B in 4 min. Peaks: 1 = metabolite, 2 = internal standard, 3 = parent drug.
THE APPLICATION NOTEBOOK – DECEMBER 2018 65
CALENDAR
66 LCGC NORTH AMERICA CORPORATE CAPABILITIES DECEMBER 2018 www.chromatographyonline.com
30 January–1 February 2019SCM-9: Ninth International
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and Characterization of
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Amsterdam, The Netherlands www.scm-9.nl
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on Plasma Spectrochemistry
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& Exhibition on Petroleum,
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16–20 June 2019HPLC 2019: 48TH
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