Coronary heart disease (CHD) - Univerzita Karlova · Coronary heart disease (CHD), Martin Vokurka...
Transcript of Coronary heart disease (CHD) - Univerzita Karlova · Coronary heart disease (CHD), Martin Vokurka...
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Coronary heart disease (CHD) , Martin Vokurka
Coronary heart disease (CHD)
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Institute of Pathological Physiology
Martin Vokurka [email protected]
Winter Semester
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CORONARY CIRCULATION AND MYOCARDIAL METABOLISM
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Blood flow: resting: 250 ml/min Main components: • coronary arteries in epicardial part • small coronary vessels • myocardium
Perfusion pressure x resistance
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Zátěžová echokardiografie, Maxdorf
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extravascular pressure
perfusion pressure
diastolic BP
high in systole higher in subendocardium myocardium diseases
vascular resistance
dilatation of larger epicard. arteries VNS β2 × α
arteriolar dilatation main mechanism of increasing the blood flow • metabolic influence • autoregulation
endothelium
+
Perfusion
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Perfusion pressure: pressure difference between the beginning of coronary arteries and estuary of coronary sinus Coronary reserve: maximal increase of blood flow through myocardium – cca 4× vasodiatation of small vessels Differences in perfusion: impaired perfusion of subendocardial parts
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Unofficial study material Zátěžová echokardiografie, Maxdorf
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Blood flow through the subendocardial vessels is less during systole than in the outer coronary vessels. To compensate, the subendocardial vessels are far more extensive than the outermost arteries, allowing a disproportionate increase in subendocardial flow during diastole.
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Because blood flow mainly occurs during diastole, there is a risk for subendocardial ischemia * diastolic pressure is low * elevation in diastolic intraventricular pressure sufficient to compress the vessels in the subendocardial plexus * rapid heart rates, the time spent in diastole is greatly reduced.
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Zátěžová echokardiografie, Maxdorf
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Oxygen extraction: almost maximal (as in intensively working skeletal muscles) AV difference: 140–160 ml O2/L blood Oxygen consumption (AV difference × flow): rest – 140 × 0,25 = 35 ml exercise – 160 × 1,00 = 160 ml Mainly achieved by increase of flow – vessel parameters are crucial for oxygen delivery to the myocardium during exercise
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Energy consumption:
• 90 % mechanical activity (contraction, relaxation)
• 9,5 % proteosynthesis
• 0,5 % electrical activity
- tension in the wall of LV ~ blood pressure
- inotropy
- heart rate
Energy sources in the myocardium: rest – FFA, glucose, lactate exercise – increase of lactate up to 2/3
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Factors infuencing oxygen consumption: • heart work • contractility • heart rate • myocardium properties: wall tension (dilatation, afterload – blood pressure), hypertrophy • adrenergic stimulation Factors infuencing oxygen delivery to the myocardium: • parcial tension of oxygen in the environment • respiratory functions • hemoglobin • blood flow through myocardium
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ISCHEMIA
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Imbalance between metabolic requirements and perfusion: 1. increased requirements– simulation by e exercise tests 2. impaired perfusion 3. combination
Ischemia
insufficient delivery of oxygen and nutrients and insufficient outflow of metabolites from the tissues due to the impaired perfusion
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Vessel narrowing • organic • functional • combined
spasmus atherom. plaque thrombus
plaque + thrombus + spasmus
spasmus
plaque rupture
thrombus
diurnal rhytm (morning!) cold smoking psychic influences
platelets: vasoconstr. factors growth factors
localisation - concentric - excentric stability - fibrotisation - lipids - inflammation
• fixed • dynamic
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Impact of the size of stenosis on hemodynamics of coronary blood flow:
• do 40 % – without influence
• 40–70 % – ischemia not apparent in physiological exercise
• 70–90 % – ischemia not in resting, distinct in exercise
• over 90 % – ischemia even in rest
Hemodynamically unimportant atherosclerotic plaque can be the cause of life-threatening myocardial infarction:
rupture ⇒ thrombus + spasmus ⇒ necrosis ⇒ arrhytmia (ventricular fibrillation) ⇒ death
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Zátěžová echokardiografie, Maxdorf
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Consequences of ischemia: · metabolic changes: ATP depletion, lokal acidosis, increased inflow of calcium to the cells · impaired contractility (decrease of stroke volume): · impaired relaxation (diastolic dysfunction) · impaired electrical events (arrhytmias, ECG) · morphological changes (myocytes, necrosis, fibrotisation, steatosis etc.) · clinical symptoms (pain, arrhytmia, heart failure)
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Postischemic changes
ischemia duration reperfusion
Stunned myocardium perfused but not functioning reversible continuous dysfunction of myocardium after reperfusion without apparent changes
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Hibernating myocardium chronically hypoperfused and functionally impaired situation with continuously decreased blood flow accompanied by impaired contractility adaptation of cells to decreased energy delivery
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Ischemic preconditioning increased resistence of myocardium against damage due to ischemia caused by preceding ischemia and reperfusion
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Reperfusion Collaterals Angiogenesis VEGF (vascular endothelial growth factor) FGF (fibroblast growth factor) Angiopoetin and others... Therapeutical angiogenesis gene therapy: direct intramyocardial aplicatioon of plasmid or use of vector (adenovirus) VEGF or FGF Revascularization by invasive treatment - PTCA (percutanneous transluminal coronary angioplastic) - stents - bypass
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Reperfusion damage
oxygen radical species: source in mitochondria, or leukocytes,xanthinoxidase (less important in myocardium) increased amount of intracellular calcium neutrophils: radical formation, mechanical plugging of capillaries, proteolytic enzymes clinically - arrhytmias
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CLINICAL FORMS OF CHD
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• Angina pectoris (AP)
• stable: fixed stenosis • atherosclerotic plaque decreases coronary
reserve, increased oxygen requirements of myocardium (tachycardia) ... subendocardial ischemia
• Other contributing factors: anemia, increased blood viscosity, diastolic hypotension, hypertrophy of myocardium
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• vasospastic (Prinzmetal): spasmus of epicardial artery, transmural ischemic changes; in rest (frequently nocturnally), reperfusion may be accompanied by arrythmia
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Mechanisms (?): - hyperactive sympathetic nervous system - defect in the handling of calcium in vascular smooth muscle - imbalance between endothelium-derived relaxing and contracting factors, incl. NO
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Unstable AP: unstable stenosis rupture, thrombosis, spasmus, uncomplete obturation + shorter time of ischemia without necrosis
Acute coronary syndromes unstable AP + acute MI
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Plaque rupture - spontaneously - triggered by hemodynamic factors blood flow characteristics vessel tension. Sudden surge of sympathetic activity: an increase in blood pressure, heart rate, force of cardiac contraction, and coronary blood flow Plaque rupture also has a diurnal variation, occurring most frequently during the first hour of arising. It has been suggested that the sympathetic nervous system is activated on arising, resulting in changes in platelet aggregation and fibrinolytic activity that tend to favor thrombosis. This diurnal variation in plaque rupture can be minimized by β-adrenergic blockers and aspirin
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Acute myocardial infarction (AMI) thrombosis leading to the necrosis of myocardium transmural (Q) nontransmural (nonQ)
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Symptoms - pain - vegetative nerves activation (anxiety, sweating, tachycardia) - atypical (without important pain, abdominal symptoms) - arrhytmias - heart failure
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Basic diagnostics Necrosis - enzymes: CK-MB, AST, LD - structural proteins: myoglobin, troponin - reaction to the necrosis: leucocytosis, RBC sedimentation rate Electrical changes - ECG: development of the curve localisation + infarction extent - arrhytmias
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Size of the necrosis - extent of the blood flow - collaterals - myocardial needs of oxygen (heart rate, wall tension - afterload / systolic BP) - ischemic preconditioning
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Sequelae of the necrosis • hemodynamic (disturbances of contractility, decrease of ejection fraction) – large necrosis or repeated infarction - heart failure, if about 40% of myocardium destroyed, cardiogenic shock can develop
• electrical instability – arrhytmias, ventricular fibrillation, sudden death
• remodelation of the ventricle – scarring, aneurysma (dyskinesis, thrombosis with embolism), dilatation – importance for prognosis • rupture of the wall, aneurysma (pericardial tamponade), septum, papillary muscle
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Localisation of the necrosis - layer of the wall: transmurale, subendocardial, intramural - part of the heart: according to the coronary artery anterior wall (RIA) lateral wall (RC) diaphragmatic (RIP)
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Syndrome X stable AP + normal coronarography small vessels
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CHD TREATEMENT
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Primary prevention Treatment of risk factors Blood flow through myocardium Vessels (calcium antagonists, vasodilatation) Decrease of oxygen consumption (betalytics) Coagulation (aspirin...) Treatment of complications Revascularization Fibrinolysis Percutaneous coronary arteries treatment – angioplastics (PTCA), stent Bypass Angiogenetic therapy Stem cells
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The End