“Corneal CXL for the Treatment of Non- Responding Infectious Keratitis ” Cristian A. Cartes, MD...
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Transcript of “Corneal CXL for the Treatment of Non- Responding Infectious Keratitis ” Cristian A. Cartes, MD...
“Corneal CXL for the Treatment of Non-Responding Infectious Keratitis ”Cristian A. Cartes, MD ; Miguel Srur, MD; Leonidas Traipe, MD
Fundación Oftalmológica los Andes, Santiago, Chile.
The authors have no financial
interest in the subject matter of
this research
Purpose
To report the use of corneal collagen crosslinking in the treatment of infective keratitis not responding to antimicrobial therapy.
Methods
Retrospective, case series of patients with infectious keratitis unresponsive to antimicrobial therapy. Patients were treated by instilling riboflavin 0.1% solution for 10 minutes to saturate the cornea, followed by exposure to UVA light for 20 minutes. The primary outcome was the time to resolution of the epithelial defect.
Results
• Eleven patients (13 eyes) were
included.
• After riboflavin and UV collagen
crosslinking therapy, there was a
rapid decrease of pain.
Results
Patient EyeGende
rVA pre
VA post
Epithelization
Melting
Emergency PKP
1 R f light light 172 no no
2 L f 0.05 0.05 Neurotrophic ulcer no no3 L f light light 142 no no4 R f cf 0.03 21 no no5 R f n.a no yes yes
L f n.a no yes yes6 L m cf cf 112 no no7 R m hm hm 22 no no8 R m 0.05 0.1 3 no no
9 L f hm cf Neurotrophic ulcer no no10 R f hm hm 45 no no
L f cf cf 82 no no11 L m n.a no yes yes
Hm: hand motion, cf: counting fingers, n.a.: not availabe
Results
38%
23%
8%
31%
Etiology
Protozoal Bacterial Fungal Unknown
Conclusion
• This serie suggests the positive effects of
riboflavin and UV collagen crosslinking on
infectious keratitis unresponsive to antimicrobial
therapy.
• We think this treatment should be considered in
refractive keratitis.
• Randomized studies are needed to further
evaluate efficacy.
“Corneal CXL for the Treatment of Non-Responding Infectious Keratitis ”Cristian A. Cartes, MD (Presenting Author); Miguel Srur, MD; Leonidas
Traipe, MD
Fundación Oftalmológica los Andes, Santiago, Chile.
Mail to: [email protected]