Core A : Administration
1
Project #4 : Biomimetic Magnetic Nanocomposites as a Platform Technology for the Capture and Sensing of PCBs Core A : Administration Core B: R esearch Support Core C: R esearch Translation Core D: Community Engagement The University of Kentucky SRP focuses on the toxicology of Superfund chemicals, with chlorinated organics as model toxins, and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition. A major objective of our program is to explore the paradigm that nutrition can modify Superfund chemical toxicity and thus modulate health and disease outcomes associated with Superfund chemical insult. Studies are underway to investigate mechanisms of adverse health effects of chlorinated organic compounds and to explore novel techniques for the detection and removal of these pollutants from the environment. Building on Successful Collaborations Building Partnerships with Communities The Community Engagement Core provides support and The Administrative Core is responsible for coordination, planning, financial oversight and information dissemination and transfer, as well as serving as a liaison between Government, University, and National SRP officials. Building a Well Organized Program Building the Integration of Research Bioinformatics The Research Support Core provides vital access to expertise, research resources and state of the art instrumentation to researchers engaged in all aspects of the components of the Student Success Project #1 : Superfund Chemicals, Nutrition , and Endothelial Cell Dysfunction The goal of this project is to investigate if nutritional intervention can protect against PCB-induced vascular inflammatory diseases by modulating endothelial cell function through cross-talk between caveolae and Nfr2 signaling. This project has implications in understanding the detrimental effects of PCBs on cardiovascular diseases such as atherosclerosis and possible protection by nutritional intervention. The overall goal of this project is to coat plant polyphenol-derived polymers onto magnetic nanoparticles for the creation of selective PCB binding domains with tunable affinity and selectivity. The coatings are engineered to have precise nanoscale thickness, tunable affinity/selectivity, and reversible binding. The biomimetic polymer coatings on the magnetic nanoparticles will allow for capture, analysis, remediation, and release on demand. Project #5 : Chloro-Organic Degradation by Polymer Membrane Immobilized Iron-Based Particle Systems The overall goal of this project is to advance the development of bimetallic/catalytic, nanostructured metal systems for reductive platform, and the influence of both hydroxyl and superoxide anion radical on the oxidative platform. Integration of these two steps will lead to the dechlorination of halogenated organics to remediated products with lower toxicity. Project #2: Postnatal Complications of Perinatal Polychlorinated Biphenyl Exposure The goals of this project are to elucidate the mechanism of low birth weight in offspring born to PCB-exposed dams, to find an intervention to block the low birth weight effect (e.g. diet or exercise), and to determine whether in utero PCB exposure will influence long-term health (e.g. inflammation, insulin resistance, and hypertension) in offspring. Research Projects Project #3 : Polychlorinated Biphenyls, Nutrition and Diabetes insulin resistance and diabetes. We hypothesize that antioxidant and anti- inflammatory effects of specific dietary polyphenolic compounds reduce harmful effects of PCBs on adipocyte TNF-α expression and glucose and insulin tolerance. The goal of this project is to investigate the mechanisms of coplanar PCB-induced regulation of adipocyte inflammation associated with decreased glucose uptake Bernhard Hennig Kevin Pearson Lisa Cassis J. Zach Hilt Core E: Interdisciplinary Training Dibakar Bhattacharyya Building Bridges Between the Disciplines The Research Translation Core is the conduit for the effective translation of UK-SRP research into policies, technological tools, and community- focused initiatives that can improve people’s lives. Andrew Morris Arnold Stromberg Lindell Ormsbee Lisa Gaetke Bernhard Hennig SUPERFUND RESEARCH PROGRAM Core Leader: Bernhard Hennig Core Leader: Lisa Gaetke Core Leader: Lindell Ormsbee Core Leader: Andrew Morris Core Leader: Bernhard Hennig Betty Newsom Jennifer Moore The Training Core prepares future scientists/engineers with thorough training in their fields, with basic knowledge about socio-economic, law, engineering, and science aspects outside Integration of Projects Biomedical Projects (Projects 1, 2, and 3) Remediation (Project 5) PCB breakdown products PCB bre akdown pr odu cts Expo sed cel ls/animal t i ss ues/flu ids Nutritio n a n d PC B Toxicity Effectiveness Com posi ti o n/ Con centration Control PCB77 PCB153 Con PCB77 Biphenyl b-actin VCAM1 Elizabeth Willett , received First- Place Biomedical Student Award at 2010 Annual SRP Meeting. UK-SRP Center Students at the 2011 SRP Meeting in Lexington, KY. UNIVERSITY OF KENTUCKY ARRA-funded undergraduate students, Summer 2011. Bernhard Hennig Student alumni of the SRP, Beth Oesterling & Xabier Arzuaga are now employed by the EPA. Maggie Murphy received Best Poster Award from Ohio Valley SOT. their fields and with an ability to communicate and cooperate with specialists in other disciplines. Capture, Sensing (Project 4) to individuals and communities affected by environmental pollutants by sharing critical, research- based programs on nutrition and Anna Hoover
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UNIVERSITY OF KENTUCKY. SUPERFUND RESEARCH PROGRAM. PCB153. PCB77. Control. - PowerPoint PPT Presentation
Transcript of Core A : Administration
Project #4: Biomimetic Magnetic Nanocomposites as a Platform Technology for the Capture and Sensing of PCBs
Core A:Administration
Core B: Research Support
Core C: Research Translation
Core D: Community Engagement
The University of Kentucky SRP focuses on the toxicology of Superfund chemicals, with chlorinated organics as model toxins, and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition. A major objective of our program is to explore the paradigm that nutrition can modify Superfund chemical toxicity and thus modulate health and disease outcomes associated with Superfund chemical insult. Studies are underway to investigate mechanisms of adverse health effects of chlorinated organic compounds and to explore novel techniques for the detection and removal of these pollutants from the environment.
Building on Successful Collaborations
Building Partnerships withCommunities
The Community Engagement Core provides support and
The Administrative Core isresponsible for coordination,planning, financial oversight andinformation dissemination andtransfer, as well as serving as aliaison between Government,University, and National SRP officials.
Building a Well Organized Program
Building the Integration of Research Bioinformatics
The Research Support Core provides vital access to expertise, research resources and state of the art instrumentation to researchers engaged in all aspects of the components of the biomedical and non-biomedical research projects.
Student SuccessProject #1: Superfund Chemicals, Nutrition, and Endothelial Cell Dysfunction
The goal of this project is to investigate if nutritional intervention can protect against PCB-induced vascular inflammatory diseases by modulating endothelial cell function
through cross-talk between caveolae and Nfr2 signaling. This project has implications in understanding the detrimental effects of PCBs on cardiovascular diseases such as atherosclerosis and possible protection by nutritional intervention.
The overall goal of this project is to coat plant polyphenol-derived polymers onto magnetic nanoparticles for the creation of selective PCB binding domains with tunable affinity and selectivity.
The coatings are engineered to have precise nanoscale thickness, tunable affinity/selectivity, and reversible binding. The biomimetic polymer coatings on the magnetic nanoparticles will allow for capture, analysis, remediation, and release on demand.
Project #5: Chloro-Organic Degradation by Polymer Membrane Immobilized Iron-Based Particle Systems
The overall goal of this project is to advance the development of bimetallic/catalytic, nanostructured metal systems for reductive platform, and the
influence of both hydroxyl and superoxide anion radical on the oxidative platform. Integration of these two steps will lead to the dechlorination of halogenated organics to remediated products with lower toxicity.
Project #2: Postnatal Complications of Perinatal Polychlorinated Biphenyl Exposure
The goals of this project are to elucidate the mechanism of low birth weight in offspring born to PCB-exposed dams, to find an intervention to block
the low birth weight effect (e.g. diet or exercise), and to determine whether in utero PCB exposure will influence long-term health (e.g. inflammation, insulin resistance, and hypertension) in offspring.
Research Projects
Project #3: Polychlorinated Biphenyls, Nutrition and Diabetes
insulin resistance and diabetes. We hypothesize that antioxidant and anti-inflammatory effects of specific dietary polyphenolic compounds reduce harmful effects of PCBs on adipocyte TNF-α expression and glucose and insulin tolerance.
The goal of this project is to investigate the mechanisms of coplanar PCB-induced regulation of adipocyte inflammation associated with decreased glucose uptake
Bernhard Hennig
Kevin Pearson
Lisa Cassis
J. Zach Hilt
Core E: Interdisciplinary Training
Dibakar Bhattacharyya
Building Bridges Between the Disciplines
The Research Translation Core is the conduit for the effective translation of UK-SRP research into policies, technological tools, and community-focused initiatives that can improve people’s lives.
Andrew Morris
Arnold Stromberg
Lindell Ormsbee Lisa Gaetke Bernhard Hennig
SUPERFUND RESEARCH PROGRAM
Core Leader: Bernhard Hennig Core Leader: Lisa GaetkeCore Leader: Lindell OrmsbeeCore Leader: Andrew Morris
Core Leader: Bernhard Hennig
Betty Newsom
Jennifer Moore
The Training Core prepares future scientists/engineers with thorough training in their fields, with basic knowledge about socio-economic, law, engineering, and science aspects outside
Integration of Projects
Biomedical Projects(Projects 1, 2, and 3)
Remediation(Project 5)
PCB breakdown products
PCB breakdown products
Expo
sed c
ells/
anim
al
tissu
es/fl
uids
Nutrition and PCB Toxicity
Effectiveness
Com
positi
on/
Conc
entra
tion
Control PCB77 PCB153
Con PCB77 Biphenyl
b-actin
VCAM1
Elizabeth Willett, received First-Place Biomedical Student Award at 2010 Annual SRP Meeting.
UK-SRP Center Students at the 2011 SRP Meeting in Lexington, KY.
UNIVERSITY OF KENTUCKY
ARRA-funded undergraduate students, Summer 2011.
Bernhard Hennig
Student alumni of the SRP, Beth Oesterling & Xabier Arzuaga are now employed by the EPA.
Maggie Murphy received Best Poster Award from Ohio Valley SOT.
their fields and with an ability to communicate and cooperate with specialists in other disciplines.
Capture, Sensing(Project 4)
to individuals and communities affected by environmental pollutants by sharing critical, research-based programs on nutrition and health-related issues.
Anna Hoover
