Copyright © 2010 Pearson Education, Inc. Marieb Chapter 16 Part A: The Endocrine System.
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Transcript of Copyright © 2010 Pearson Education, Inc. Marieb Chapter 16 Part A: The Endocrine System.
Copyright © 2010 Pearson Education, Inc.
Marieb Chapter 16 Part A: The Endocrine System
Copyright © 2010 Pearson Education, Inc.
Endocrine System: Overview
• Acts with the nervous system to coordinate and integrate the activity of body cells
• Influences metabolic activities by means of hormones transported in the blood
• Responses occur more slowly but tend to last longer than those of the nervous system
• Endocrine glands: pituitary, thyroid, parathyroid, adrenal, and pineal glands
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Endocrine System: Overview
• Some organs produce both hormones and exocrine products (e.g., pancreas)
• The hypothalamus has both neural and endocrine functions
• Secondary endocrine tissues include adipose cells, thymus, cells in the walls of the small intestine, stomach, kidneys, and heart
Copyright © 2010 Pearson Education, Inc. Figure 16.1
Pineal glandHypothalamus
Pituitary gland
Parathyroid glands(on dorsal aspectof thyroid gland)Thymus
Thyroid gland
Adrenal glands
Pancreas
Ovary (female)
Testis (male)
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Chemical Messengers: Review
• Hormone:
• Autocrines:
• Paracrines:
• Autocrines and paracrines are local chemical messengers and are not considered part of the endocrine system
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Chemistry of Hormones
• Three main classes
1. Peptides
• Examples include:
2. Catecholamines
• Examples include:
3. Steroids
• Examples include:
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Peptides/Proteins
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Catecholamines, Biogenic Amines, Amines
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Steroids
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Target Cell Activation
• Target cell activation depends on three factors
1. Blood levels of the hormone
2. Relative number of receptors on or in the target cell
3. Affinity of binding between receptor and hormone
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Hormones in the Blood
• Hormones are removed from the blood by
• Degrading enzymes
• Kidneys
• Liver
• These factors influence a hormone’s half-life
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Half-LifeDefinition:
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Interaction of Hormones at Target Cells
• Multiple hormones may interact in several ways!
• Permissiveness:
• Synergism:
• Antagonism:
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Control of Hormone Release
• Blood levels of hormones
• Are controlled by negative feedback systems
• Vary only within a narrow desirable range
• Hormones are synthesized and released in response to
1. Humoral stimuli
2. Neural stimuli
3. Hormonal stimuli
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Humoral Stimuli
• Changing blood levels of ions and nutrients directly stimulates secretion of hormones
• Example: Ca2+ in the blood
• Declining blood Ca2+ concentration
• This hormone causes Ca2+ concentrations to
Copyright © 2010 Pearson Education, Inc. Figure 16.4a
(a) Humoral Stimulus
Capillary (lowCa2+ in blood)
Parathyroidglands
Thyroid gland(posterior view)
PTH
Parathyroidglands
1 Capillary blood containslow concentration of Ca2+,which stimulates…
2 …secretion ofparathyroid hormone (PTH)by parathyroid glands*
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Neural Stimuli
• Nerve fibers stimulate hormone release
• Example:
Copyright © 2010 Pearson Education, Inc. Figure 16.4b
(b) Neural Stimulus
CNS (spinal cord)
Medulla ofadrenalgland
Preganglionicsympatheticfibers
Capillary
1 Preganglionic sympatheticfibers stimulate adrenalmedulla cells…
2 …to secrete catechola-mines (epinephrine andnorepinephrine)
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Hormonal Stimuli
• Hormones stimulate other endocrine organs to release their hormones
• Involve feedback loops
Copyright © 2010 Pearson Education, Inc. Figure 16.4c
(c) Hormonal Stimulus
Hypothalamus
Thyroidgland
Adrenalcortex
Gonad(Testis)
Pituitarygland
1 The hypothalamus secreteshormones that…
2 …stimulatethe anteriorpituitary glandto secretehormonesthat…
3 …stimulate other endocrineglands to secrete hormones
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Feedback Loops and Hormone Regulation
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Feedback Loops and Hormone Regulation
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The Pituitary Gland and Hypothalamus
• The pituitary gland (hypophysis) has two major lobes
1. Posterior pituitary (lobe) (neurohypophysis):
• Glial-like cells and nerve fibers
2. Anterior pituitary (lobe) (adenohypophysis)
• Glandular tissue
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Basic Anatomy of the Pituitary & Hypothalamus
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Posterior Pituitary & Hypothalamus
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Anterior Pituitary & Hypothalamus
Copyright © 2010 Pearson Education, Inc. Figure 16.5a
1
2
3
4
Hypothalamicneuronssynthesize oxytocin and ADH.
Oxytocin and ADH aretransported along the hypothalamic-hypophyseal tract to the posterior pituitary.
Oxytocin and ADH arestored in axon terminals in the posterior pituitary.
Oxytocin and ADH are released into the blood when hypothalamic neurons fire.
Paraventricularnucleus Supraopticnucleus Optic chiasma
Hypothalamus
Inferiorhypophyseal artery
OxytocinADH
Infundibulum (connecting stalk)Hypothalamic-hypophysealtract
Axon terminalsPosteriorlobe ofpituitary
(a) Relationship between the posterior pituitary and the hypothalamus
Neurohypophysis
Copyright © 2010 Pearson Education, Inc. Figure 16.5b
1
2
3
When appropriatelystimulated, hypothalamic neurons secrete releasing and inhibiting hormones into the primary capillary plexus.
Hypothalamic hormones travel through the portal veins to the anterior pituitary where they stimulate or inhibit release of hormones from the anterior pituitary.
Anterior pituitaryhormones are secreted into the secondary capillary plexus.
Hypothalamus
Hypothalamic neuroncell bodies
Hypophysealportal system
Superiorhypophyseal artery
(b) Relationship between the anterior pituitary and the hypothalamus
Anterior lobeof pituitaryTSH, FSH, LH, ACTH, GH, PRL
• Primary capillary plexus• Hypophyseal portal veins• Secondary capillary plexus
Adenohypophysis
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Posterior Pituitary Hormones - Oxytocin
• Oxytocin is released during labor (stimulates uterine contractions); Pitocin is synthetic oxytocin
• Also released when an infant suckles at the breast, starts breast feeding
• NEWS FLASH! Called the :”cuddle hormone”; thought to be involved in parent child bonding, autism, trust, and empathy
• Gee,it fixes everything! (NOT!) http://oxytocinblog.com/
• https://www.verolabs.com/Default.asp?affl=sas
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Posterior Pituitary Hormones - ADH
• ADH stands for
• Its other names are vasopressin or AVP
• Action =
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Posterior Pituitary Hormones - ADH
• ADH Actions
• Drink a 44 oz diet coke
• Work out without fluid intake
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Posterior Pituitary Hormones - ADH
• Too much ADH? You have SIADH
• Too little ADH? You have diabetes insipidus
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Anterior Pituitary Hormones
• Growth hormone (GH)
• Thyroid-stimulating hormone (TSH)
• Adrenocorticotropic hormone (ACTH)
• Follicle-stimulating hormone (FSH)
• Luteinizing hormone (LH)
• Prolactin (PRL)
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Anterior Pituitary Hormones
• All are proteins
• All except GH activate cyclic AMP second-messenger systems at their targets
• TSH, ACTH, FSH, and LH are all _________ hormones (regulate the secretory action of other endocrine glands)
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Hypothalamic and AP Hormones
Hypo
AP
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Growth Hormone (GH)• Stimulates most cells, but primarily targets bone and
skeletal muscle
• Causes protein synthesis and use of fats for fuel
• Most effects are mediated indirectly by insulin-like growth factors (IGFs) = hormones
• GH release is regulated by
• (GHRH)
• (GHIH)
(AKA: somatostatin)
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Actions of Growth Hormone
• Direct action of GH
• Stimulates liver, skeletal muscle, bone, and cartilage to produce insulin-like growth factors
• Mobilizes fats, elevates blood glucose by decreasing glucose uptake and encouraging glycogen breakdown (anti-insulin effect of GH)
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Homeostatic Imbalances of Growth Hormone• Hypersecretion
• In children results in gigantism
Andre the Giant
Robert Wadlow
• In adults results in acromegaly
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Homeostatic Imbalances of Growth Hormone
• Hypersecretion
• Hyposecretion
• In children results in
pituitary dwarfism
Copyright © 2010 Pearson Education, Inc. Figure 16.6
Growth hormone
Feedback Inhibits GHRH releaseStimulates GHIHreleaseInhibits GH synthesisand release
Anteriorpituitary
Liver andother tissues
Indirect actions(growth-promoting)
Direct actions(metabolic,anti-insulin)
Insulin-like growthfactors (IGFs)
ExtraskeletalSkeletal FatCarbohydratemetabolism
Increased cartilageformation and
skeletal growth
Increased proteinsynthesis, andcell growth and
proliferation
Increasedfat breakdown
and release
Increased bloodglucose and otheranti-insulin effects
EffectsEffects
Produce
Hypothalamussecretes growthhormone—releasinghormone (GHRH), andsomatostatin (GHIH)
Initial stimulus
Physiological response
Result
Increases, stimulates
Reduces, inhibits
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Thyroid-Stimulating Hormone (Thyrotropin)
• Regulation of TSH release
• Stimulated by thyrotropin-releasing hormone (TRH)
• Inhibited by rising blood levels of thyroid hormones that act on the pituitary and hypothalamus
Copyright © 2010 Pearson Education, Inc. Figure 16.7
Hypothalamus
Anterior pituitary
Thyroid gland
Thyroidhormones
TSH
TRH
Target cellsStimulates
Inhibits
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Adrenocorticotropic Hormone (ACTH)
• Secreted by glandular cells of the anterior pituitary
• Stimulates the adrenal cortex to release corticosteroids
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Adrenocorticotropic Hormone (ACTH)
• Regulation of ACTH release
• Triggered by hypothalamic corticotropin-releasing hormone (CRH) in a daily rhythm
• Internal and external factors such as fever, hypoglycemia, and stressors can alter the release of CRH
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Gonadotropins
• Follicle-stimulating hormone (FSH) and luteinizing hormone (LH)
• Secreted by glandular cells of the anterior pituitary
• FSH stimulates gamete (egg or sperm) production
• LH promotes production of gonadal hormones
• Absent from the blood in prepubertal boys and girls
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Gonadotropins
• Regulation of gonadotropin release
• Triggered by the gonadotropin-releasing hormone (GnRH) during and after puberty
• Suppressed by gonadal hormones (feedback)
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Prolactin (PRL)
• Secreted by glandular cells of the anterior pituitary
• Stimulates milk production
• Regulation of PRL release
• Primarily controlled by prolactin-inhibiting hormone (PIH) (dopamine)
• Blood levels rise toward the end of pregnancy
• Suckling stimulates PRH release and promotes continued milk production