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![Page 1: Copyright © 2007, 2004, 2000, Mosby, Inc., an affiliate of Elsevier Inc. All Rights Reserved. Napa Valley College ADN N142 Unit IV Endocrine/Diabetes.](https://reader031.fdocuments.us/reader031/viewer/2022032702/56649cac5503460f9496e718/html5/thumbnails/1.jpg)
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Napa Valley College
ADN N142
Unit IV Endocrine/Diabetes
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Objective #1 Explain factors that promote the normal reg. of BG in health
Normal insulin metabolism
– Produced by the cells • Islets of Langerhans
– Released continuously into bloodstream in small increments with larger amounts released after food intake
– Stabilizes glucose range to 70 to 120 mg/dl– Average daily secretion 0.6 units/kg body weight
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Normal Insulin Secretion
Fig. 49-1Fig. 49-1
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BG Homeostasis
High Blood Glucose
Pancreas releases insulin
Cells take up Liver produces
Glucose from glycogenBlood
Blood Glucose Falls
Low Blood Glucose
Pancreas releases glucagon
Liver breaks down glycogen
Blood Glucose Rises
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Obj#2 factors that influence glucose regulation
Glucose Regulation
• Insulin• Decreases glucose in the bloodstream• Insulin ↑ after a meal• Stimulates storage of glucose as glycogen in liver
and muscle• Inhibits gluconeogenesis• Enhances fat deposition• ↑ Protein synthesis • Promotes glucose transport from bloodstream
across cell membrane to cytoplasm of cell
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Glucose Regulation• Stress
– Emotional and physical can increase BG levels
• Medications– Can potentiate hypo/hyper glycemic effects
• Exercise• Counterregulatory hormones
– Oppose effects of insulin– Increase blood glucose levels– Provide a regulated release of glucose for energy– Help maintain normal blood glucose levels– Examples
• Glucagon, epinephrine, growth hormone, cortisol
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Obj#3 Define & describe
Diabetes Mellitus• A chronic multisystem disease related to
– Abnormal insulin production– Impaired insulin utilization – Or both
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Diabetes Mellitus
• Leading cause of – End-stage renal disease– Adult blindness– Nontraumatic lower limb amputations
• Major contributing factor– Heart disease– Stroke
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Diabetes Mellitus
• 73% of adults with diabetes have hypertension
• 23.6 million people with diabetes in the US
• 41 million people with prediabetes
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Obj#4 Compare the etiology & characteristicsObj#5factors that indicate pts at risk for altered glucose regulation
Diabetes MellitusEtiology and Pathophysiology
• Two most common types– Type 1– Type 2
• Other types– Gestational – Prediabetes– Secondary diabetes
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Type 1 (Immune-mediated)Diabetes Mellitus
• Formerly known as “juvenile onset” or “insulin dependent” diabetes
• Most often occurs in people under 30 years of age
• Peak onset between ages 11 and 13
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Type 1 Diabetes MellitusEtiology and Pathophysiology
• End result of long-standing process – Progressive destruction of pancreatic
cells by body’s own T cells– Autoantibodies cause a reduction of 80% to
90% of normal cell function before manifestations occur
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Type 1 Diabetes MellitusEtiology and Pathophysiology
• Causes– Theories link cause to single/ combination of
these factors– Genetic– Autoimmune– Viral– Environmental
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Type 1 Diabetes MellitusOnset of Disease
• Long preclinical period• Antibodies present for months to years before
symptoms occur• Manifestations develop when pancreas can no
longer produce insulin– Rapid onset of symptom– Will require exogenous insulin to sustain life
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Type 1 Diabetes Mellitus Clinical Manifestation
• History of recent, sudden, weight loss
• Classic symptoms– Polydipsia– Polyuria– Polyphagia
• Weight loss
• Weakness
• Fatigue
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obj#7 manifestations that suggest an alteration in glucose reg.
Clinical ManifestationType 1
Lack of insulin results in:– Glucose molecules accumulate= hyperglycemia
• which causes hyperosmolality (drawing H2O from the intracellular spaces into circulation)
• The increased blood vol. increases renal blood flow
– Acting as a osmotic diuretic» INCREASES URINE OUTPUT=
»POLYURIA
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Clinical Manifestation type 1continued…
• When the BG level exceeds the renal threshold for glucose: (about 180mg/dL)
– Glucose is excreted in the urine-glucosuria
• The decrease in intracellular vol. & the increased urinary output cause dehydration– Thirst sensors are activated causing pt to drink
increased amts of fluid= POLYDIPSIA
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Clinical Manifestation type 1continued
– Because glucose cannot enter the cell without insulin, energy production decreases• Stimulates hunger
• Person wants/eats more food =POLYPHAGIA
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Obj #8 pathological changes in DM
Clinical Manifestationscontinued
• Weight loss
– acute - loss of H2O, glycogen, triglyceride stores
– chronic - muscle mass• Blurred vision -
– effect of hyperosmolar fluid on lenses & retina• Fatigue, Malaise & Dizziness
fluid volume & K+, postural hypotension, protein catabolism
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Type 2 Diabetes Mellitus
• Most prevalent type of diabetes
• Over 90% of patients with diabetes
• Usually occurs in people over 35 years of age
• 80% to 90% of patients are overweight
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Type 2 Diabetes
• Prevalence increases with age• Genetic basis• Greater in some ethnic populations
– Increased rate in African Americans, Asian Americans, Hispanic Americans, and Native Americans
– Native Americans and Alaskan Natives: Highest rate of diabetes in the world
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Type 2 Diabetes MellitusEtiology and Pathophysiology
• Pancreas continues to produce some endogenous insulin
• Insulin produced is either insufficient or poorly utilized by tissues
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Type 2 Diabetes MellitusEtiology and Pathophysiology
• Obesity (abdominal/visceral) – Most powerful risk factor
• Genetic mutations– Lead to insulin resistance – Increased risk for obesity– http://cosmos.bcst.yahoo.com/up/player/popu
p/?cl=7492540
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Type 2 DiabetesEtiology and Pathophysiology
Major metabolic abnormalities– 1. Insulin resistance
• Body tissues do not respond to insulin– Insulin receptors either unresponsive or insufficient in number
• Results in hyperglycemia
– 2. Pancreas ↓ ability to produce insulin• β cells fatigued from compensating• β -cell mass lost
– 3. Inappropriate glucose production from liver• Liver’s response of regulating release of glucose is
haphazard• Not considered a primary factor in development of type 2
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Type 2 Diabetes Etiology and Pathophysiology
• Individuals with metabolic syndrome (“Syndrome X”) are at increased risk for type 2:– Cluster of abnormalities that increase risk for
cardiovascular disease and diabetes• Elevated insulin levels, ↑ triglycerides &
LDLs, ↓ HDLs, hypertension– Risk factors
• Central obesity, sedentary lifestyle, urbanization, certain ethnicities
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Type 2 Diabetes MellitusOnset of Disease
• Gradual onset
• Person may go many years with undetected hyperglycemia
• Osmotic fluid/electrolyte loss from hyperglycemia may become severe– Hyperosmolar coma
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Clinical ManifestationsType 2 Diabetes Mellitus
• Nonspecific symptoms – May have classic symptoms of type 1
• Fatigue• Recurrent infections • Recurrent vaginal yeast infections (Candida)• Prolonged wound healing• Visual changes
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Prediabetes
• Known as:• Impaired fasting glucose (IFG)
– Fasting glucose levels higher than normal (>100 mg/dl, but <126 mg/dl)
OR• Impaired glucose tolerance
– 2 hour plasma glucose higher than normal (between 140 and 199 mg/dl)
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Glucose Continuum
Fig. 49-3Fig. 49-3
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Prediabetes
• Not high enough for diabetes diagnosis• Increase risk for developing type 2 diabetes• If no preventive measure taken—usually
develop diabetes within 10 years• Long-term damage already occurring
– Heart, blood vessels• Usually present with no symptoms• Must watch for diabetes symptoms
– Polyuria– Polyphagia– Polydipsia
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Gestational Diabetes
• Develops during pregnancy• Detected at 24 to 28 weeks of gestation• Usually glucose levels back to normal at
6 weeks postpartum• Increased risk for cesarean delivery, perinatal
death, and neonatal complications• Increased risk for developing type 2 in
5 to 10 years • Therapy: First nutritional, second insulin
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Obj#9 nursing care for pts requiring diagnostic studies
Diabetes MellitusDiagnostic Studies
• Four methods of diagnosis– A1c >6.5%– Fasting plasma glucose level >126 mg/dl– Random or casual plasma glucose
measurement ≥ 200 mg/dl plus symptoms– Two-hour OGTT level ≥ 200 mg/dl using a
glucose load of 75g
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Diabetes MellitusDiagnostic Studies
• Hemoglobin A1C test (also called glycosylated hemoglobin)– Useful in determining glycemic levels over time– ADA recommends to diagnose (feb 2010)– Shows the amount of glucose attached to hemoglobin
molecules over RBC life span • 90 to 120days
– Ideal goal • ADA 6.5%• American College of Endocrinology <6.5%
– Normal A1C reduces risk of retinopathy, nephropathy, and neuropathy
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Chronic Complications
Fig. 49-14Fig. 49-14
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Obj#10 Chronic conditions & complications
DiabetesChronic Complications
• Angiopathy– Macrovascular
• Diseases of large and medium-sized blood vessels
– Heart, Cerebral vascular, Peripheral vascular
• Patients with diabetes should be screened for dyslipidemia at diagnosis
• Tight glucose control may delay atherosclerotic process
• Risk factors
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DiabetesChronic Complications
• Angiopathy (cont’d)– Microvascular
• Result from thickening of vessel membranes in capillaries and arterioles
– In response to chronic hyperglycemia• Is specific to diabetes unlike macrovascular
– Areas most noticeably affected• Eyes (retinopathy)• Kidneys (nephropathy)• Skin (dermopathy)
– Clinical manifestations usually appear after 10 to 20 years of diabetes
•
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DiabetesChronic Complications
• Diabetic retinopathy– Microvascular damage to retina– Most common cause of new cases of blindness in
people 20 to 74 years– Must have annual dilated eye examinations
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DiabetesChronic Complications
• Diabetic retinopathy (cont’d)– Nonproliferative
• Most common form• Partial occlusion of small blood vessels in retina
– Causes development of microaneurysms– Capillary fluid leaks out
» Retinal edema and eventually hard exudates or intraretinal hemorrhages occur
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DiabetesChronic Complications
• Diabetic retinopathy (cont’d)– Proliferative
• Most severe form• Involves retina and vitreous• When retinal capillaries become occluded
– Body forms new blood vessels– Vessels are extremely fragile and
hemorrhage easily» Produce vitreous contraction
– Retinal detachment can occur
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DiabetesChronic Complications
• Diabetic nephropathy– Associated with damage to small blood vessels that
supply the glomeruli of the kidney– Leading cause of end-stage renal disease– Yearly screening
• Microalbuminuria in urine • Serum creatinine
– Critical factors for prevention/delay• Tight glucose control• Blood pressure management
– Angiotensin-converting enzyme (ACE) inhibitors
» Used even when not hypertensive
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DiabetesChronic Complications
• Diabetic neuropathy– 60% to 70% of patients with diabetes have
some degree of neuropathy– Nerve damage due to metabolic
derangements of diabetes– Sensory versus autonomic neuropathy
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DiabetesChronic Complications
• Diabetic neuropathy (cont’d)– Sensory
• Treatment– Tight blood glucose control– Drug therapy
» Topical creams» Tricyclic antidepressants» Selective serotonin and norepinephrine
reuptake inhibitors» Antiseizure medications
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DiabetesChronic Complications
• Diabetic neuropathy (cont’d)– Sensory neuropathy
• Distal symmetric – Most common form – Affects hands and/or feet bilaterally– Characteristics include
» Loss of sensation, abnormal sensations, pain, and paresthesias
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DiabetesChronic Complications
• Diabetic neuropathy (cont’d)– Sensory
• Usually worse at night• Foot injury and ulcerations can occur without the
patient having pain• Can cause atrophy of small muscles of hands/feet
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Neuropathy: Neurotrophic Ulceration
Fig. 49-15Fig. 49-15
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DiabetesChronic Complications
• Diabetic neuropathy (cont’d)– Autonomic
• Can affect nearly all body systems• Complications
– Gastroparesis» Delayed gastric emptying
– Cardiovascular abnormalities– Sexual function– Neurogenic bladder
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DiabetesChronic Complications
• Complications of foot and lower extremity– Foot complications
• Most common cause of hospitalization in diabetes• Result from combination of microvascular and macrovascular
diseases– Risk factors
• Sensory neuropathy• Peripheral arterial disease
– Other contributors• Smoking• Clotting abnormalities• Impaired immune function• Autonomic neuropathy
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Necrotic Toe Before and After Amputation
Fig. 49-16Fig. 49-16
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DiabetesChronic Complications
• Integumentary complications– Acanthosis nigricans
• Dark, coarse, thickened skin
– Necrobiosis lipoidica diabeticorum• Associated with type 1• Red-yellow lesions • Skin becomes shiny, revealing tiny blood vessels
– Granuloma annulare• Associated mainly with type 1• Forms partial rings of papules
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DiabetesChronic Complications
• Infection– Diabetics more susceptible to infections– Defect in mobilization of inflammatory cells – Loss of sensation may delay detection– Treatment must be prompt and vigorous
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Obj#11 pathophys & manifestations of acute complications of DM 1&2
DiabetesAcute Complications
• Diabetic ketoacidosis (DKA)
• Hyperosmolar hyperglycemic syndrome (HHS)
• Hypoglycemia
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DiabetesAcute Complications
• DKA
– Caused by profound deficiency of insulin– Characterized by
• Hyperglycemia• Ketosis• Acidosis• Dehydration
– Most likely occurs in type 1diabetic – Occurs in absence of exogenous insulin– Life-threatening condition– Results in metabolic acidosis
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DiabetesAcute Complications
• DKA (cont’d)– When supply of insulin insufficient
• Glucose cannot be properly used for energy• Body breaks down fats stores
– Ketones are by-products of fat metabolism
– Precipitating factors• Illness• Infection• Inadequate insulin dosage• Undiagnosed type 1• Poor self-management• Neglect
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DiabetesAcute Complications
• DKA (cont’d)– Signs and symptoms
• Lethargy/weakness (early sympt), dehydration• Abdominal pain
– N/V• Kussmaul respirations
– Rapid deep breathing– Attempt to reverse metabolic acidosis– Sweet fruity odor
– Serious condition• Must be treated promptly
– Depending on signs/symptoms• May or may not need hospitalization
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DiabetesAcute Complications
• DKA (cont’d)– Laboratory findings
• Blood glucose > 300 mg/dl• Arterial blood pH below 7.30• Serum bicarbonate level <15 mEq/L• Ketones in blood and urine
– Correct fluid/electrolyte imbalance• IV infusion 0.45% or 0.9% NaCl • When blood glucose levels approach 250 mg/dl
– 5% dextrose added to regimen– Prevent hypoglycemia
• Potassium replacement• Sodium bicarbonate
– If pH <7
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DiabetesAcute Complications
• DKA (cont’d)– Airway management
• O2 administration
– Insulin therapy• Withheld until fluid resuscitation has begun• Bolus followed by insulin drip
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DiabetesAcute Complications
• Hyperosmolar hyperglycemic syndrome (HHS)– Life-threatening syndrome– Less common than DKA– Often occurs in patients over 60 years with type 2 – Patient has enough circulating insulin so ketoacidosis
does not occur– Produces fewer symptoms in earlier stages– Neurologic manifestations occur due to ↑ serum
osmolality
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DiabetesAcute Complications
• HHS (cont’d)– Usually history of
• Inadequate fluid intake• Increasing mental depression• Polyuria
– Laboratory values• Blood glucose >400 mg/dl• Increase in serum osmolality• Absent/minimal ketone bodie
– Therapy similar to DKA• Except HHS requires greater fluid replacement
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DiabetesAcute Complications
• Nursing management DKA/HHS– Patient closely monitored
• Administration – IV fluids– Insulin therapy– Electrolytes
• Signs potassium imbalance• Cardiac monitoring • Vital signs• Level of consciousness
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DiabetesAcute Complications
• Hypoglycemia– Low blood glucose– Occurs when
• Too much insulin in proportion to glucose in the blood• Blood glucose level less than 70 mg/dl
– Common manifestations• Confusion• Irritability• Diaphoresis• Tremors• Hunger
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DiabetesAcute Complications
• Hypoglycemia (cont’d)– Common manifestations
• Weakness• Visual disturbances• Can mimic alcohol intoxication
– Untreated can progress to loss of consciousness, seizures, coma, and death
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DiabetesAcute Complications
• Hypoglycemia (cont’d)– Hypoglycemic unawareness
• Person does not experience warning signs/symptoms, increasing risk for decreased blood glucose levels
– Related to autonomic neuropathy
– Causes• Mismatch in timing
– Food intake and peak action of insulin or oral hypoglycemic agents
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DiabetesAcute Complications
• Hypoglycemia (cont’d)– At the first sign
• Check blood glucose – If <70 mg/dl, begin treatment– If >70 mg/dl, investigate further for cause of
signs/symptoms– If monitoring equipment not available, treatment should
be initiated
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DiabetesAcute Complications
• Hypoglycemia (cont’d)– Treatment
• If alert enough to swallow– 15 to 20 g of a simple carbohydrate
» 4 to 6 oz fruit juice» Regular soft drink
– Avoid foods with fat» Decrease absorption of sugar
– Do not overtreat– Recheck blood sugar 15 minutes after treatment– Repeat until blood sugar >70 mg/dl– Patient should eat regularly scheduled meal/snack to
prevent rebound hypoglycemia– Check blood sugar again 45 minutes after treatment
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DiabetesAcute Complications
• Hypoglycemia (cont’d)– Treatment
• If no improvement after 2 or 3 doses of simple carbohydrate or pt not alert enough to swallow
• Administer 1 mg of glucagon IM or subcutaneously– Side effect: Rebound hypoglycemia
• Have patient ingest a complex carbohydrate after recovery
• In acute care settings– 20 to 50 ml of 50% dextrose IV push
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Obj#12 Assessment findings in pts with alterations in glucose regulation
Nursing ManagementNursing Assessment
• Past health history– Viral infections– Medications– Recent surgery
• Positive health history
• Obesity
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Nursing ManagementNursing Assessment
• Weight loss
• Thirst
• Hunger
• Poor healing
• Kussmaul respirations
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Obj#13 Identify nursing dx and outcomes for pts with DM
Nursing ManagementNursing Diagnoses
• Ineffective therapeutic regimen management• Risk for injury• Risk for infection• Powerlessness• Imbalanced nutrition: More than body
requirements• Fluid volume deficit• Tissue perfusion, altered• Altered sexuality patterns
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Nursing ManagementPlanning
• Overall goals– Active patient participation– Few or no episodes of acute hyperglycemic
emergencies or hypoglycemia – Maintain normal blood glucose levels– Prevent or delay chronic complications– Lifestyle adjustments with minimal stress
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Nursing ManagementNursing Implementation
• Health promotion– Identify those at risk– Routine screening for overweight adults over
age 45• FPG is preferred method in clinical settings
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Nursing ManagementNursing Implementation
• Acute intervention– Hypoglycemia– Diabetic ketoacidosis– Hyperosmolar hyperglycemic nonketotic
syndrome
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Nursing ManagementNursing Implementation
• Acute intervention (cont’d)– Stress of illness and surgery
• ↑ Blood glucose level • Continue regular meal plan• ↑ Intake of noncaloric fluids• Continue taking oral agents and insulin• Frequent monitoring of blood glucose
– Ketone testing if glucose > 240 mg/dl
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Nursing ManagementNursing Implementation
• Acute intervention (cont’d)– Stress of illness and surgery
• Patients undergoing surgery or radiologic procedures requiring contrast medium should hold their metformin day of surgery and 48 hours
– Begun after serum creatinine has been checked and is normal
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Nursing ManagementNursing Implementation
• Ambulatory and home care– Overall goal is to enable patient or caregiver
to reach an optimal level of independence – Insulin therapy and oral agents– Personal hygiene
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Nursing ManagementNursing Implementation
• Ambulatory and home care (cont’d)– Insulin therapy and oral agent
• Education on proper administration, adjustment and side effects
• Assessment of patient’s response to therapy
– Personal hygiene• Regular bathing with emphasis on foot care• Daily brushing/flossing
– Dentist should be informed about diabetes diagnosis
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Nursing ManagementNursing Implementation
• Ambulatory and home care (cont’d)– Medical identification and travel card
• Must carry identification indicating diagnosis of diabetes– Patient and family teaching
• Educate on disease process, physical activity, medications, monitoring blood glucose, diet, resources
• Enable patient to become most active participant in his/her care
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Diabetes MellitusCollaborative Care
• Goals of diabetes management– Decrease symptoms– Promote well-being– Prevent acute complications– Delay onset and progression of
long-term complications
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Diabetes MellitusCollaborative Care
• Patient teaching– Self-monitoring of blood glucose
• Nutritional therapy
• Drug therapy
• Exercise
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Obj#15 Formulate outcomes from use of Insulin and Oral hypoglycemic agents.
Drug TherapyInsulin
• Exogenous insulin– Insulin from an outside source– Required for type 1 diabetes– Prescribed for patient with type 2 diabetes who
cannot control blood glucose by other means
• Types of insulin– Human insulin
• Only type used today• Prepared through genetic engineering
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Drug TherapyInsulin
• Regimen that closely mimics endogenous insulin production is basal-bolus– Long-acting (basal) once a day– Rapid/short-acting (bolus) before meals
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Drug TherapyInsulin
Insulin preparations• Rapid-acting (bolus) Lispro, aspart, glulisine
• onset 0 to 15 minutes• Peak 60-90 min• Duration 3-4 hours
• Short-acting (bolus) Regular• Onset 30 to 60 minutes• Peak 2-3 hours• Duration 3-6 hours
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Drug TherapyInsulin
• Intermediate Acting NPH or Lente• Cloudy• Vial must be rolled or rocked a min of 20 times • onset 2-4 hours• Peak 4-10• Duration 10-16
• Long-acting (basal) glargine (Lantus), detemire (Levemir)
• Injected once a day at bedtime or in the morning• Onset 1-2 hours• Duration 24+ hours• No peak action-released steadily and continuously• Cannot be mixed with any other insulin or solution
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Insulin Preparations
Fig. 49-4Fig. 49-4
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Drug TherapyInsulin
• Storage of insulin– Do not heat/freeze– In-use vials may be left at room temperature up to 4
weeks– Extra insulin should be refrigerated– Avoid exposure to direct sunlight
• Administration of insulin– Cannot be taken orally– Subcutaneous injection for
self-administration – IV administration
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Drug TherapyInsulin
• Administration of insulin (cont’d)– Fastest absorption from abdomen, followed by arm,
thigh, buttock– Abdomen
• Preferred site
– Rotate injections within one particular site– Do not inject in site to be exercised
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Subcutaneous Injection Sites
Fig. 49-6Fig. 49-6
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Drug TherapyInsulin
• Administration of insulin (cont’d)– Do not inject in site to be exercised – Usually available as U100
• 1 ml contains 100 units of insulin
– No alcohol swab on site needed before injection– washing with soap and rinsing with water is adequate– Do not recap needle– 45- to 90-degree angle depending on fat thickness of
patient– Insulin pens preloaded with insulin now available
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Insulin Pen
Fig. 49-7Fig. 49-7
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Drug TherapyInsulin
• Insulin pump– Continuous subcutaneous infusion– Battery operated device – Connected via plastic tubing to a catheter
inserted into subcutaneous tissue in abdominal wall
– Potential for tight glucose control
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Insulin Pump
Fig. 49-8Fig. 49-8
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Drug TherapyInsulin
• Inhaled insulin– Exubera
• Rapid-acting, dry powder inhaled through mouth into lungs
• Not recommended for patients with asthma, bronchitis, or emphysema
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Drug TherapyInsulin
• Problems with insulin therapy– Hypoglycemia– Allergic reactions– Lipodystrophy – Somogyi effect – Dawn phenomenon
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Drug TherapyInsulin
• Problems with insulin therapy– Somogyi effect
• Rebound effect in which an overdose of insulin causes hypoglycemia
• Usually during hours of sleep• Counterregulatory hormones released
– Rebound hyperglycemia and ketosis occur
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Drug TherapyInsulin
• Problems with insulin therapy– Dawn phenomenon
• Characterized by hyperglycemia present on awakening in the morning
– Due to release of counterregulatory hormones in predawn hours
– Growth hormone/cortisol possible factors
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Drug TherapyOral Agents
• Not insulin
• Work to improve mechanisms by which insulin and glucose are produced and used by the body
• Work on three defects of type 2 diabetes– Insulin resistance– Decreased insulin production– Increased hepatic glucose production
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Drug TherapyOral Agents
• Sulfonylureas
• Meglitinides
• Biguanides
• α-Glucosidase inhibitors
• Thiazolidinediones
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Drug TherapyOral Agents
• Sulfonylureas– ↑ Insulin production from pancreas– ↓ Chance of prolonged hypoglycemia– 10% experience decreased effectiveness after
prolonged use– Examples
• Glipizide (Glucotrol)• Glimepiride (Amaryl)
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Drug TherapyOral Agents
• Meglitinides– Increase insulin production from pancreas– Taken 30 minutes before each meal up to time of
meal– Should not be taken if meal skipped– Examples
• Repaglinide (Prandin)• Nateglinide (Starlix)
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Drug TherapyOral Agents
• Biguanides– Reduce glucose production by liver– Enhance insulin sensitivity at tissues– Improve glucose transport into cells– Does not promote weight gain– Example
• Metformin (Glucophage)
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Drug TherapyOral Agents
• α-Glucosidase inhibitors– “Starch blockers”
• Slow down absorption of carbohydrate in small intestine
– Example• Acarbose (Precose)
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Drug TherapyOral Agents
• Thiazolidinediones– Most effective in those with insulin resistance– Improves insulin sensitivity, transport, and utilization
at target tissues– Examples
• Pioglitazone (Actos)• Rosiglitazone (Avandia)
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Drug TherapyOther Agents
• Amylin analog– Hormone secreted by cells of pancreas– Cosecreted with insulin– Indicated for type 1 and type 2 diabetics– Administered subcutaneously
• Thigh or abdomen
– Slows gastric empyting, reduces postprandial glucagon secretion, increases satiety
– Example• Pramlintide (Symlin)
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Drug TherapyOther Agents
• Incretin mimetic– Synthetic peptide – Stimulates release of insulin from cells– Subcutaneous injection– Suppresses glucagon secretion – Reduces food intake– Slows gastric emptying– Not to be used with insulin– Example
• Byetta
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Drug TherapyOther Agents
-Adrenergic blockers– Mask symptoms of hypoglycemia– Prolong hypoglycemic effects of insulin
• Thiazide/loop diuretics– Can potentiate hyperglycemia
• By inducing potassium loss
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Obj #14 rationale for interventions that maintain or restore health for pt with DM
DiabetesNutritional Therapy
• Cornerstone of care for person with diabetes
• Most challenging for many people • Recommended that diabetes nurse
educator and registered dietitian with diabetes experience be members of team
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DiabetesNutritional Therapy
• American Diabetes Association (ADA)– Guidelines indicate that within context of an
overall healthy eating plan, person with diabetes can eat same foods as person who does not have diabetes
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DiabetesNutritional Therapy
• American Diabetes Association (ADA) (cont’d)– Overall goal
• Assist people in making changes in nutrition and exercise habits that will lead to improved metabolic control
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DiabetesNutritional Therapy
• Type 1 diabetes mellitus– Meal plan based on individual’s usual food
intake and is balanced with insulin and exercise patterns
– Insulin regimen managed day to day
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DiabetesNutritional Therapy
• Type 2 diabetes mellitus– Emphasis based on achieving glucose, lipid,
and blood pressure goals– Calorie reduction
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DiabetesNutritional Therapy
• Food composition– Nutrient balance of diabetic diet is essential– Nutritional energy intake should be balanced
with energy output
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DiabetesNutritional Therapy
• Carbohydrates– Carbohydrates and monounsaturated fats
should provide 45% to 65% of total energy intake
– ↓ Carbohydrate diets are not recommended for diabetics
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DiabetesNutritional Therapy
• Glycemic index (GI)– Term used to describe rise in blood glucose
levels after consuming carbohydrate-containing food
– Should be considered when formulating a meal plan
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DiabetesNutritional Therapy
• Fats– No more than 20% to 35% of meal plan’s total
calories• <7% from saturated fats, minimal trans fat
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DiabetesNutritional Therapy
• Protein– Contribute <10% of total energy consumed– Intake should be significantly less than
general population
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DiabetesNutritional Therapy
• Alcohol– High in calories– No nutritive value– Promotes hypertriglyceridemia– Detrimental effects on liver– Can cause severe hypoglycemia
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DiabetesNutritional Therapy
• Diet teaching– Dietitian initially provides instruction– Should include patient’s family and significant others– USDA MyPyramid guide
• An appropriate basic teaching tool
– Plate method• Helps patient visualize the amount of vegetable, starch, and
meat that should fill a 9-inch plate
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Diabetes Exercise
• Exercise– Essential part of diabetes management– ↑ Insulin receptor sites – Lowers blood glucose levels– Contributes to weight loss
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Diabetes Exercise
• Exercise (cont’d)– Several small carbohydrate snacks can be taken
every 30 minutes during exercise to prevent hypoglycemia
– Best done after meals– Exercise plans should be started
• After medical clearance• Slowly with gradual progression
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Diabetes Exercise
• Exercise (cont’d)– Should be individualized– Monitor blood glucose levels before, during,
and after exercise
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Monitoring Blood Glucose
• Self-monitoring of blood glucose (SMBG)– Enables patient to make self-management
decisions regarding diet, exercise, and medication
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Monitoring Blood Glucose
• Self-monitoring of blood glucose (SMBG) (cont’d)– Important for detecting episodic
hyperglycemia and hypoglycemia – Patient training is crucial – Supplies immediate information about blood
glucose levels
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Blood Glucose Monitors
Fig. 49-9Fig. 49-9 Fig. 49-10Fig. 49-10
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DiabetesPancreas Transplantation
• Used for patients with type 1 diabetes who also have– End-stage renal disease– Had, or plan to have, a kidney transplant
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DiabetesPancreas Transplantation
• Pancreas transplants alone are rare– Usually kidney and pancreas transplants done
together
• Eliminates need for exogenous insulin• Can also eliminate hypoglycemia and
hyperglycemia
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Nursing ManagementEvaluation
• Knowledge
• Balance of nutrition
• Immune status
• Health benefits
• No injuries
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Necrobiosis Lipidoidica Diabeticorum
Fig. 49-17Fig. 49-17
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DiabetesGerontologic Considerations
• Prevalence increases with age• Hypoglycemia unawareness is more common • Presence of delayed psychomotor function could
interfere with treating hypoglycemia• Must consider patient’s own desire for treatment
and coexisting medical problems
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DiabetesGerontologic Considerations
• Recognize limitations in physical activity, manual dexterity and visual acuity
• Education based on individual’s needs, using slower pace