Copper- Naturally Antimicrobial Mark Tur CDA Technical Consultant Copper Development Association ...

Copper-Naturally Antimicrobial

Mark TurCDA Technical Consultant

Copper Development Association

www.copperinfo.co.uk/antimicrobial/

Antimicrobial Copper:

Recent Developments

©CDA 2009 2Copper-Naturally Antimicrobial

1. Review

2. Recent science &

3. Clinical trials

4. Future

5. Conclusions

Antimicrobial Copper


Copper – early observations & science

• 19th Century: immunity to cholera & treatment of arthritis

• 20th Century: • immunity to arthritis in copper miners in Finland (Hangarter)

• further studies into inflammatory conditions• treatment of rheumatoid arthritis & associated problems• early work on use of copper to combat Legionella


Review of scientific work

1994… Southampton University: verifying efficacy of copper and copper alloys against pathogens

2006 Effective against MRSA

2007 C. Difficile – paper submitted

MRSA Viability on Copper & Stainless Steel @ 20oC

1

100

10,000

1,000,000

100,000,000

0 60 120 180 240 300 360Time (minutes)B

acte

ria

Co

un

t (p

er m

l.)

C197 S304


Review of scientific field work

1983 Hamot Hosp, PA, USA: study of brass vs stainless doorknobs

2005 Rural Punjab & Uni. of Northumbria: E. Coli eliminated from drinking water – Punjab

2007 Started work at UHB Selly Oak, UK


Recent Science: C. diff.

Survival of Clostridium difficile on copper and steel: futuristic options for hospital hygiene.

Weaver L, Michels HT, Keevil CW.

Environmental Healthcare Unit, School of Biological Sciences, University of Southampton, Southampton, UK.

The Journal of hospital infection. 01/03/2008; 68(2):145-51.

m

m


Recent Science – C. diff.

Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory

L. J. Wheeldon1, T. Worthington1,, P. A. Lambert1, A. C. Hilton1, C. J. Lowden1 and T. S. J. Elliott2

1 Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK

2 University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Letters in Applied Microbiology ISSN 0266-8254 © 2009 The Authors.Journal compilation © 2009 The Society for Applied Microbiology, Letters in Applied Microbiology 49 (2009) 191–195 191.


Recent Science: H1N1 influenza A

Inactivation of Influenza A Virus on Copper versus Stainless Steel Surfaces

J. O. Noyce,1 H. Michels,2 and C. W. Keevil1

Environmental Healthcare Unit, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, United Kingdom 1 Copper Development Association, Inc., 260 Madison Avenue, New York, New York 100162

Copyright © 2007, American Society for Microbiology. All Rights Reserved.


Recent Science: EPA Registration

Almost 300 alloys have been exhaustively tested under independent GLP conditions

MRSA Count on Copper & S304: 8 Inoculations over 24 Hours

03,000,0006,000,0009,000,000

12,000,00015,000,00018,000,00021,000,00024,000,00027,000,000

0 3 6 9 12 15 18 21 24

Time (hours)

CFU

s pe

r co

upon C110 Stainless Steel


Recent Science

Effects of temperature and humidity on the efficacy of methicillin-resistant Staphylococcus aureus challenged antimicrobial

materials containing silver and copper

Letters in Applied Microbiology ISSN 0266-8254 © 2009 The Authors.

Journal compilation © 2009 The Society for Applied Microbiology, Letters in Applied

Microbiology 49 (2009) 191–195 191.

MRSA viability on copper, S304 & others at 20oC

1

100

10,000

1,000,000

100,000,000

0 60 120 180 240 300 360

Time (mins)

CF

U p

er

Co

up

on

C11000 S30400 AgB AgA TS


Recent science

1994… Southampton University: verifying efficacy of copper and copper alloys

2006 effective against MRSA

2007 C. Difficile – including spores

- Influenza A (H1N1)

- Mycobacterium tuberculosis

2008 USA EPA registration of about 300 alloys

2009 Copper tested under ambient conditions

- Vancomycin-resistant Enterococci (VRE)

1. Acinetobacter baumannii 2. Adenovirus3. Aspergillus niger 4. Candida albicans5. Campylobacter jejuni 6. Clostridium difficile7. Enterobacter aerogenes 8. Escherichia coli O157:H79. Helicobacter Pylori 10. Influenza A (H1N1)11. Legionella pneumophila 12. Listeria monocytogenes13. MRSA14. Mycobacterium tuberculosis15. Poliovirus16. Pseudomonas aeruginosa 17. Salmonella enteritidis18. Staphylococcus aureus 19. Tubercle bacillus20. Vancomycin-resistant

enterococcus (VRE)


Recent Science – clinical results

Copper for preventing microbial environmental contamination

AL Casey,1 PA Lambert,2 L Miruszenko,1 TSJ Elliott1

1 University Hospital Birmingham NHS Foundation Trust, Birmingham UK2 Aston University, Birmingham UK

90 – 100% less microbes on copper and copper alloy surfaces than on control surfaces


Recent Science – clinical results

Antimicrobial efficacy of copper touch surfaces in reducing environmental bioburden in a South African community healthcare facility

F. Maraisa,b, S. Mehtara and L. Chalkleya

a Academic Unit for Infection Prevention and Control, Department of Community Health, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Western Cape, South Africab Division of Nursing, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Western Cape, South Africa

m

m


Selly Oak clinical trial

Practical aspects of reducing bioburden with copper - Selly Oak Hospital Case Study

IHEEM, Harrogate, Oct 2009



Conclusions: why use copper alloy fittings?

2. recognisable & available

4. easy to install & maintain

3. comparable in cost, with exceptions

5. no significant disruption

6. timetabled into refurbishment projects

1. they work

7. long lasting and “scratch proof”


1. Why?

2. What was replaced?

3. How readily?

4. How much extra?

5. Worth it?

Copper at Selly Oak Hospital

It works

Hot spots

Easily

£6,000 per 20 beds

Review:

Save one infection to generate payback


Clinical & field based science

1983 Hamot Hosp, PA, USA: study of brass vs stainless doorknobs

2005 Rural Punjab & Uni. of Northumbria: E. Coli eliminated from drinking water – Punjab

2008 UHB Selly Oak, UK – phase 1 reported at ICAAC

2009 UHB Selly Oak, UK – phase 1 paper in press

- Asklepios, Wandsbek, Germany – phase 1 report in draft

2010 Selly Oak phase 2 report expected

- Three centre clinical trials in USA report expected

- South American clinical trial results expected

2011 Infection data from USA clinical trials expected


Copper applications – the future

• copper/prion binding being investigated




• copper in air systems - USC




• copper in air systems

• copper/resin composite for injection moulded parts






• copper as an enhanced catalyst







• copper nickel alloy for cryogenics

• copper nickel alloys for cryogenics




• process development – hot metal gas forming

• copper in filtered air systems






• process development – HEATform




• process development – hot metal gas forming






…future?

2009? First “commercial” clinic, unit & hospital fit outs

2010… Product development:

- scaling up existing lab equipment

- use in medical devices

Copper-Naturally Antimicrobial

Mark TurCDA Technical Consultant

Copper Development Association

www.copperinfo.co.uk/antimicrobial/

Antimicrobial Copper: Recent Developments

Thank you

Copper- Naturally Antimicrobial Mark Tur CDA Technical Consultant Copper Development Association ...

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